Crab-eating Monkey Skull (Macaca fascicularis) - The crab-eating monkey is native to southeast Asia as well as Indonesia and the Philippine islands. As in most old-world primates, the crab-eating monkey has the same tooth count as humans. This species is omnivorous, eating a variety of plant parts and, as its name suggests, crustaceans and other small invertebrates. This monkey is commonly eaten by humans.
As part of a long-range investigation of the cardiopulmonary response in monkeys exposed to toxic materials, normal electrocardiograms of 16 male cynomolgus monkeys (Macaca fascicularis), 3 to 5 years old, were studied. With the animals restrained in a sitting position, electrocardiograms were measured and were found to be similar to those of other subhuman primates. Standard and augmented limb le
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Large species differences exist in sensitivity to aflatoxin B1 (AFB1)-induced liver cancer. Mice are resistant to AFB1-induced liver cancer because they express an alpha-class GST (mGSTA3-3) that has high activity toward the reactive intermediate aflatoxin B1-8,9-epoxide (AFBO). Rats constitutively express only small amounts of a GST with high AFBO activity (rGSTA5-5) and thus are sensitive to AFB1-induced hepatocarcinogenesis, although induction of rGSTA5-5 can confer resistance in rats. In contrast to rodents, constitutively expressed human hepatic alpha-class GSTs have little or no AFBO detoxifying activity. Recently, we found that the nonhuman primate, Macaca fascicularis (Mf), has significant constitutive hepatic GST activity toward AFBO and most of this activity belongs to mu-class GSTs. To determine if any alpha-class GSTs in Mf liver have AFBO activity, a cDNA library from a male Mf liver was constructed and screened using the human alpha-class GstA1 cDNA as a probe. Three different cDNA ...
Methods and Results-Adult male Cynomolgus monkeys were fed a normal or atherogenic (AS) diet for 45 months, after which animals from the AS group were placed on a normal diet for 8 months (regression). The expression of membrane-associated EGF-like ligands was increased in arteries from animals on the AS diet and normalized in the regression group. EGF-like ligands were distributed throughout atherosclerotic vessels but predominantly colocalized with macrophages. Consistent with ligand shedding, circulating heparin-bound EGF was elevated in the plasma of AS monkeys but not in those on regression diet. Atherosclerosis was associated with the activation of EGF receptor signaling. Expression of nicotinamide adenine dinucleotide phosphate oxidase subunits Nox1 and Nox2 but not Nox4 or Nox5 was increased in arteries from monkeys on the AS diet and returned to normal with regression. Levels of Nox1 and Nox2 positively correlated with EGF-like ligands. In cultured monkey smooth muscle cells, treatment ...
Sufugolix (INN, BAN) (developmental code name TAK-013) is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). It was under development by Takeda for the treatment of endometriosis and uterine leiomyoma and reached phase II clinical trials for both of these indications, but was subsequently discontinued. It seems to have been supplanted by relugolix (TAK-385), which is also under development by Takeda for the treatment of these conditions and has a more favorable drug profile (including reduced cytochrome P450 inhibition and improved in vivo GnRHR antagonistic activity) in comparison. Oral administration of sufugolix at a dose of 30 mg/kg to castrated male cynomolgus monkeys resulted in nearly complete suppression of luteinizing hormone levels. The duration of action was more than 24 hours, indicating a long elimination half-life of the drug. The suppressive effects ...
68. Rhynchospora fascicularis (Michaux) Vahl, Enum. Pl. 2: 234. 1805 (as Rynchospora). Schoenus fascicularis Michaux, Fl. Bor.-Amer. 1: 37. 1803; Dichromena distans (Michaux) J. F. Macbride; Phaeocephalum fasciculare (Michaux) House; P. distans (Michaux) House; Rhynchospora distans (Michaux) Vahl; R. distans var. fascicularis (Michaux) Kükenthal; R. dommucensis A. H. Moore; R. fascicularis var. distans (Michaux) Chapman; Schoenus distans Michaux. Plants perennial, cespitose, 100-150 cm; rhizomes absent. Culms erect to excurved ascending, narrowly linear to ± filiform, terete to obscurely trigonous, leafy, densely so toward base, stiff to rather lax. Leaves overtopped by culm; blades linear, ascending, proximally flat, 1-4 mm wide, apex trigonous, subulate, tapering gradually. Inflorescences: spikelet clusters 1-3(-4), proximal mostly widely spaced, dense, broadly turbinate to hemispheric, to 2 cm broad; leafy bracts subulate, exceeding proximal spikelets, slightly or not exceeding most distal ...
This subspecies is listed as Vulnerable as the population is estimated at less than a 1,000 individuals in total (including mature individuals). Although the range of this subspecies is very limited the island on which it lives is a national park, and there are no obvious threats that would lead it to decline very quickly ...
In vitro maturation (IVM) of oocytes followed by fertilization in vitro (IVF) and embryo transfer offers an alternative to conventional IVF treatment that minimises drug administration and avoids ovarian hyperstimulation. However, the technique is less efficient than maturation in vivo. In the present study, a non-human primate model was used to address the hypothesis that the number of oocytes is increased and their nuclear and cytoplasmic maturity after IVM are improved when maturation is initiated in vivo by priming with hCG. Young, adult cynomolgus monkeys were given recombinant human (rh) gonadotropins to stimulate the development of multiple follicles, and oocytes were aspirated 0, 12, 24, or 36 h after injection of an ovulatory dose of rhCG. The nuclear status of oocytes was determined at the time of recovery and after culture for a total elapsed time of 40-44 hours after hCG. Priming with hCG significantly increased the number of oocytes harvested, especially after delaying aspiration for 24 h
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. Involved in the regulation of bone mineralization.
Human farming and the introduction of domestic dogs are posing a threat to the ability of Burmese long-tailed macaques to use stone tools. This was found in a study led by Nanyang Technological University (NTU) carried out ...
This study examined the effect of GnRH-antagonist (GnRH-A)-induced gonadotrophin withdrawal on numbers of germ cells in adult cynomolgus monkeys and aimed to identify the site of the earliest spermatogenic lesion(s) produced. Animals received either GnRH-A (Cetrorelix; 450 μg kg−1 day−1 s.c.; n = 5) or vehicle (control, n = 4) for 25 days. One testis was removed on day 16 and the other testis on day 25. The optical disector stereological method was used to estimate germ and Sertoli cell numbers per testis. After GnRH-A treatment for 16 days, the number of type A spermatogonia was unchanged; however, type B spermatogonia (15% of control), preleptotene + leptotene + zygotene (15% control) and pachytene (55% control) spermatocytes were all reduced (P ,0.05). By day 25, these cells were further reduced together with step 1-6 spermatids (38% control; P , 0.05). More mature germ cells were unaffected. The proportion of type A pale spermatogonia at stages VII-XII was reduced (P ,0.05) in ...
Cynomolgus Monkey Pancreatic Epithelial Cells from Creative Bioarray are isolated from normal Cynomolgus Monkey pancreatic tissue. Cynomolgus Monkey Pancreatic Epithelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells at passage 3 are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10 ...
Among the animal models of tuberculosis (TB), the non-human primates (NHPs), particularly rhesus macaques (Macaca fascicularis) and cynomolgus macaques (Macaca mulatta), share the greatest anatomical and physiological similarities with humans. Macaques are highly susceptible to Mycobacterium tuberculosis infection and manifest the complete spectrum of clinical and pathological manifestations of TB as seen in humans. Therefore, the macaque models have been used extensively for investigating the pathogenesis of M. tuberculosis infection and for preclinical testing of drugs and vaccines against TB. This review focuses on published major studies that exemplify how the rhesus and cynomolgus macaques have enhanced and may continue to advance global efforts in TB research.
In an effort to improve air quality and decrease dependence on petroleum, alternative fuels such as methanol have been considered to substitute for gasoline or diesel fuel. Methanol is also a candidate to provide the hydrogen for fuel cells. Before people are exposed to increased concentrations of methanol, the potential health effects of such exposures require study. Dr. Burbacher and colleagues of the University of Washington studied the effects of long-term exposure to methanol vapors on metabolism and reproduction in adult female monkeys (Macaca fascicularis) and developmental effects in their offspring, who were exposed prenatally to methanol.
The claustrum is present in all mammalian species examined so far and its morphology, chemoarchitecture, physiology, phylogenesis and ontogenesis are still a matter of debate. Several morphologically distinct types of immunostained cells were described in different mammalian species. To date, a comparative study on the neurochemical organization of the human and non-human primates claustrum has not been fully described yet, partially due to technical reasons linked to the postmortem sampling interval. The present study analyzes the localization and morphology of neurons expressing parvalbumin (PV), calretinin (CR), NPY, and somatostatin (SOM) in the claustrum of man (# 5), chimpanzee (# 1) and crab-eating monkey (#3). Immunoreactivity for the used markers was observed in neuronal cell bodies and processes distributed throughout the anterior-posterior extent of human, chimpanzee and macaque claustrum. Both CR- and PV-immunoreactive (ir) neurons were mostly localized in the central and ventral region of
Urgently looking for CD14 antibody that would work on formalin fixed paraffin embedded tissues of cynomolgus monkeys. Has anybody worked with one ...
Nobody can deny the devastating effects of malaria on humans. It is a disease that kills hundreds of thousands of people each year. But primates, not even chimpanzees, who are evolutionarily close to humans - are not good models for human disease. Researchers not only use macaque monkeys, but they also do not specify the species required. The long-tailed macaque (Macaca fascicularis) AND the rhesus macaque (M. mulatta) are listed to be used. These researchers appear oblivious to the fact that there are vast and important genetic differences between species. It begs to question, why did the Animal Welfare and Ethical Review Body - responsible for overseeing animal experiments - grant ethical approval for an experiment, without even knowing the exact species to be used?. "In the field of vaccine development, the use of non-human primates has been a spectacular failure" - Dr. Andre Menache BSc (Hons), BVSc, Dip. ECAWBM (AWSEL), MRCVS, Animal Justice Project Science Advisor.. There are far more ...
Young C; Majolo B; Heistermann M; Schülke O; Ostner J (2014). Responses to social and environmental stress are attenuated by strong male bonds in wild macaques. P Natl Acad Sci USA (PNAS) 111: 18195-18200. Rimbach R; Link A; Montes-Rojas A; Di Fiore, A; Heistermann M; Heymann EW (2014). Behavioral and physiological responses to fruit availability of spider monkeys ranging in a small forest fragment. Am J Primatol 76: 1049-1061. - PDF available via open access - Mandalaywala T; Higham JP; Heistermann M; Parker KJ; Maestripieri D (2014). Physiological and behavioural responses to weaning conflict in free-ranging primate infants. Anim Behav 97: 241-247. Girard-Buttoz C; Heistermann M; Rhami E; Agil M; Fauzan PA; Engelhardt A (2014). Costs of mate-guarding in wild male long-tailed macaques (Macaca fascicularis): Physiological stress and aggression. Horm Behav 66: 637-648. - PDF available via open access - Balestri M; Barresi M; Campera M; Serra V; Ramanamanjato JB; Heistermann M; Donati G (2014). ...
1984). Location and function of voltagesensitive conductances in retinal rods of the salamander, Ambystoma tigrinum. Journal of Physiology, 354, 203-223. 28 Paul Shin-Hyun Park Baylor, D. , Nunn, B. , & Schnapf, J. L. (1984). The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis. Journal of Physiology, 357, 575-607. Becker, R. , & Freedman, K. (1985). A comprehensive investigation of the mechanism and photophysics of isomerization of a protonated and unprotonated Schiff-base of 11-cis-retinal. L. (2003). Assessing structural elements that influence Schiff base stability: Mutants E113Q and D190N destabilize rhodopsin through different mechanisms. Vision Research, 43, 2991-3002. Janz, J. , Fay, J. , & Farrens, D. L. (2003). Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2. The Journal of Biological Chemistry, 278, 16982-16991. , Cornwall, M. , & Oprian, D. D. (2003). Opsin activation as a cause of congenital night ...
When we reached the entrance to Chek Jawa, there was a troupe of long-tailed macaques (Macaca fascicularis) there. And much to my dismay, I saw one of them eating a packet of nasi lemak! While some visitors may find this to be cute, I personally felt that we should never feed wild animals, either deliberately or unintentionally. Please look after your food in a nature area, as once these wild animals got used to getting human food, they may eventually get into the habit of harassing humans for food. This may also result in them losing the ability to find food in the wild ...
SWISS-MODEL Repository entry for Q95K04 (RN133_MACFA), E3 ubiquitin-protein ligase RNF133. Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Crab-eating macaque ALDOB vectors (from $99), available in lentivirus, AAV, adenovirus, shRNA, CRISPR & many other formats from VectorBuilder.
Crab-eating macaque AAMDC vectors (from $99), available in lentivirus, AAV, adenovirus, shRNA, CRISPR & many other formats from VectorBuilder.
Animal subjects. The animal subjects in this project were surgically menopausal cynomolgus macaques (Macaca fascicularis). These animals have several distinct reproductive similarities to women, including a nonseasonal 28-day menstrual cycle, cyclic ovarian hormone profile, and natural menopause ( 22, 23). Unlike women, menopause occurs in macaques very late in their life span, generally within 5 years of natural death ( 24). Naturally menopausal animals are therefore relatively rare and short-lived, and ovariectomized macaques are more widely used as a primate model of menopause. An important feature of the macaque model is the unique degree of similarity to the human breast. Despite differences in gross appearance, human and macaque breasts have similar lobuloalveolar and ductal patterns, cytokeratin phenotype, sex steroid receptor expression, steroidogenic enzyme distribution and activity, and responses to endogenous and exogenous hormones ( 25- 27).. Study design. Thirty-one adult female ...
... Catalog No. MK-6019. Suggested Medium: Catalog No. M2267 Fibroblast Medium /w Kit (500 ml). Product Description. Monkey Primary Liver Fibroblasts from Cell Biologics are isolated from tissue of Cynomolgus Monkey. Monkey Primary Liver Fibroblasts are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Cell Biologics Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x106 cells per ml and is delivered frozen. Monkey Primary Liver Fibroblasts are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-6 passages at a split ratio of 1:3 under the cell culture conditions specified by Cell Biologics. Repeated freezing and thawing of cells is not recommended.. Laboratory Applications. Standard biochemical procedures performed with ...
Mullerian inhibiting substance (MIS) is a glycoprotein hormone produced in Sertoli cells of the fetal and postnatal testis, and granulosa cells of the pubertal ovary. We examined MIS expression in a nonhuman primate, the cynomolgus macaque monkey (Macaca fascicularis), to define an animal model for studying MIS gene regulation. Changes in testicular MIS mRNA with age were assessed by in situ hybridization of prepubertal to adult testes, Northern analysis of pubertal and adult specimens, and determination of serum MIS concentrations from infancy to adulthood. We found that MIS expression was highest in the youngest animals and decreased progressively with increasing age. Serum MIS concentrations correlated inversely with increasing age (r = -0.74), body weight (r = -0.79), and testicular volume (r = -0.73), but not with testosterone levels (r = -0.35). The mean MIS concentrations +/- SEM for the four developmental age groups were 270.6 +/- 23.8 (infants), 195.5 +/- 18.5 (juveniles), 102.7 +/- 28.4
3H]Methotrexate ([3H]MTX) was entrapped inside sonically disrupted, positively charged, [14C]cholesterol-labeled liposomes. Its distribution and metabolic integrity was then studied after a single injection into the cerebrospinal fluid (CSF) in the lateral cerebroventricles of cynomolgus monkeys (Macaca fascicularis). Between 24 and 96 hr after injection, a maximal 4-fold increase in average tissue levels, compared with the levels found after injection of free [3H]MTX, was found for total central nervous system (brain plus spinal cord). Greater increased levels of [3H]MTX after injection of liposome-entrapped [3H]MTX compared with free [3H]MTX were found in CSF, but considerable variation was noted according to the site of sampling. Metabolic degradation of free MTX, as measured by the difference between MTX determined by 3H-specific activity and MTX determined by the dihydrofolate reductase assay, was detected at 24 hr, and 96 hr after injection only 11% of the free MTX in CSF represented ...
In 1996, Dolly the sheep became the first mammal to be cloned from a somatic cell. Twenty years later, scientists have succeeded in using the same technique on primates. Two long-tailed macaque monkeys were born at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai.
, Monkey Serum (Cynomolgus) - 500mL, GTX73296, Applications: Blocking, ELISA, ICC/IF, IHC, WB; Blocking, ELISA, Immunocytochemistry/ Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Western Blot (WB); CrossReactivity:
decapod having eyes on short stalks and a broad flattened carapace with a small abdomen folded under the thorax and pincers. ...
Zyagen : Monkey Tissue cDNA - Antibodies Kits, Reagents & Biochemical Tissue Sections RNA Products cDNA Products Genomic DNA Products Tissue Lysates Products Premade Northern Blots Premade Western Blots Recombinant Proteins & Peptides Tissue Microarrays
CD61 (Integrin beta 3) Mouse anti-Baboon, Canine, Cynomolgus Monkey, Human, Rhesus Monkey, PerCP-eFluor 710, Clone: VI-PL2, eBioscience 100 Tests; PerCP-eFluor™ 710
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Adrenal Lysate Catalog Number: 21-160 By Type: Tissue Species: Cynomolgus monkey Diagnosis: Normal Tested Applications: WB Size: 0.1 mg ...
TY - JOUR. T1 - Ultrastructural study of the primary olfactory pathway in Macaca fascicularis. AU - Herrera, Loren P.. AU - Casas, Carlos E.. AU - Bates, Margaret L.. AU - Guest, James D. PY - 2005/8/8. Y1 - 2005/8/8. N2 - Olfactory ensheathing glial cells (OEGs) interact with a wide repertoire of cell types and support extension of olfactory axons (OAs) within the olfactory pathway. OEGs are thought to exclude OAs from contact with all other cells between the olfactory epithelium and the glomerulus of the olfactory bulb. These properties have lead to testing to determine whether OEGs support axonal growth following transplantation. The cellular interactions of transplanted OEGs will probably resemble those that occur within the normal pathway where interactions between OEGs and fibroblasts are prominent. No previous primate studies have focused on these interactions, knowledge of which is important if clinical application is envisioned. We describe the detailed intercellular interactions of OAs ...
We compared the performance of dichromats and trichromats in a discrimination task. We examined tri- and dichromatic individuals of two species: brown capuchin monkeys (Cebus apella) and long-tailed macaques (Macaca fascicularis). We also examined one protanomalous chimpanzee (Pan troglodytes). The results demonstrate that dichromatic nonhuman primates possess a superior visual ability to discriminate color-camouflaged stimuli, and that such an ability may confer selective advantages with respect to the detection of cryptic foods and/or predators. ...
1. Four Macaca fascicularis monkeys were bilaterally sympathectomized by removing the thoracic sympathetic chain from the middle cervical ganglion to the T-6 sympathetic ganglion. This was done chronically, allowing adequate recovery time. While under light pentobarbital anaesthesia, the animals were then subjected to blood volume expansions with isotonic, isooncotic dextran or to head-out immersions. Seven immersions and seven volume expansions were carried out.. 2. With immersion, there were significant increases in blood pressure, central venous pressure, urine flow, sodium excretion, potassium excretion, glomerular filtration rate, percentage of filtered sodium excreted and free water clearance. Although blood pressure and central venous pressure initially increased during the first immersion period, heart rate continued to increase with the immersion, while blood pressure and central venous pressure remained constant. Volume expansion caused an increase in central venous pressure, urine ...
The evidence in the literature supporting the role of soy in the reduction of TPC and LDL-C is extensive.22 There are also experimental studies demonstrating the protection against atherosclerosis development by soy protein relative to animal proteins such as casein.23,24 Many studies have attempted to determine the components of soy protein responsible for its hypocholesterolemic effect, but at best only a partial answer has been found. The amino acid composition of soy has been thoroughly investigated for its effect on plasma lipids and its role in atherosclerosis prevention.25-30 Generally, vegetable protein amino acid reconstitutions were not as effective in lowering plasma cholesterol as the intact proteins, but animal protein amino acid reconstitutions induced a similar degree of hypercholesterolemia as the intact proteins.25-27 An outgrowth of the amino acid composition hypothesis was investigation of the lysine:arginine ratio. Both Kritchevskys group28,29 and Sugano and coworkers30 ...
Pharmacokinetics of cefovecin in cynomolgus macaques (Macaca fascicularis), olive baboons (Papio anubis), and rhesus macaques (Macaca mulatta).: Cefovecin sodiu
Ebola virus (EBOV) is considered one of the most aggressive infectious agents and is capable of causing death in humans and nonhuman primates (NHPs) within days of exposure. Recent strategies have succeeded in preventing acquisition of infection in NHPs after treatment; however, these strategies are only successful when administered before or minutes after infection. The present work shows that a combination of three neutralizing monoclonal antibodies (mAbs) directed against the Ebola envelope glycoprotein (GP) resulted in complete survival (four of four cynomolgus macaques) with no apparent side effects when three doses were administered 3 days apart beginning at 24 hours after a lethal challenge with EBOV. The same treatment initiated 48 hours after lethal challenge with EBOV resulted in two of four cynomolgus macaques fully recovering. The survivors demonstrated an EBOV-GP-specific humoral and cell-mediated immune response. These data highlight the important role of antibodies to control EBOV ...
Age assessment in infant crab-eating monkeys (Macaca fascicularis) based on tooth development (pages 247-252). J. M. Ostyn, J. C. Maltha and F. P. G. M. van der Linden. Version of Record online: 14 MAY 2009 , DOI: 10.1111/j.1469-7998.1995.tb05141.x. ...
479000617 - EP 3182999 A1 2017-06-28 - ANTI-LAG3 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS - [origin: WO2016028672A1] The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD1 antibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the antibodies and fragments are part of the present invention.[origin: WO2016028672A1] The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains thereof and
The crab-eating fox is predominantly greyish-brown, with areas of red on the face and legs, and black-tipped ears and tail. It has short, strong legs and its tail is long and bushy. It may reach an adult weight of 10 to 17 pounds (4.5 to 7.7 kg). The head and body length averages 64.3 centimetres (25.3 in), and the average tail length is 28.5 centimetres (11.2 in).[9] This fox weighs between 10 to 17 pounds (4.5 to 7.7 kg).[10][11] It is mainly nocturnal and also is active at dusk, spending its day in dens that were dug by other animals. It either hunts individually or lives in pairs; it eats crabs, lizards and different flying animals. It is easy to domesticate and farm, but its fur is not so highly valued as that of other species. The coat is short and thick. Coloration varies from grey to brown, to yellowish, to pale, to dark grey. There is a black streak along the back legs, with a black stripe along the spine. On muzzle, ears and paws there is more-reddish fur. The tail, legs and ear tips ...
The crab-eating fox is predominantly greyish-brown, with areas of red on the face and legs, and black-tipped ears and tail. It has short, strong legs and its tail is long and bushy. It may reach an adult weight of 10 to 17 pounds (4.5 to 7.7 kg). The head and body length averages 64.3 centimetres (25.3 in), and the average tail length is 28.5 centimetres (11.2 in) (Berta, 1982). This fox weighs between 5 to 8 kilograms (11 to 18 lb) (A. Hover; C Yahnke, 2003). It is mainly nocturnal and also is active at dusk, spending its day in dens that were dug by other animals. It either hunts individually or lives in pairs; it eats crabs, lizards and different flying animals. It is easy to domesticate and farm, but its fur is not so highly valued as that of other species.. The coat is short and thick. Coloration varies from grey to brown, to yellowish, to pale, to dark grey. There is a black streak along the back legs, with a black stripe along the spine. On muzzle, ears and paws there is more-reddish fur. ...
Cynomolgus macaques (Macaca fascicularis) were introduced on the island of Mauritius between 400 and 500 years ago and underwent a strong population expansion after a probable initial founding event. However, in practice, little is known of the geographical origin of the individuals that colonized the island, on how many individuals were introduced, and of whether the following demographic expansion erased any signal of this putative bottleneck. In this study, we asked whether the current nuclear genome of the Mauritius population retained a signature that would allow us to answer these questions. Altogether, 21 polymorphic autosomal and sex-linked microsatellites were surveyed from 81 unrelated Mauritius individuals and 173 individuals from putative geographical sources in Southeast Asia: Java, the Philippines islands and the Indochinese peninsula. We found that (i) the Mauritius population was closer to different populations depending on the markers we used, which suggests a possible mixed ...