Prior to the start of cross-sex hormone therapy (CSH), androgenic progestins are often used to induce amenorrhea in female to male (FtM) pubertal adolescents with gender dysphoria (GD). The aim of this single-center study is to report changes in anthropometry, side effects, safety parameters, and hormone levels in a relatively large cohort of FtM adolescents with a diagnosis of GD at Tanner stage B4 or further, who were treated with lynestrenol (Orgametril®) monotherapy and in combination with testosterone esters (Sustanon®). A retrospective analysis of clinical and biochemical data obtained during at least 6 months of hormonal treatment in FtM adolescents followed at our adolescent gender clinic since 2010 (n = 45) was conducted. McNemars test to analyze reported side effects over time was performed. A paired Students t test or a Wilcoxon signed-ranks test was performed, as appropriate, on anthropometric and biochemical data. For biochemical analyses, all statistical tests were done in comparison
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Background: Many dilated cardiomyopathy (DCM) patients have improvement in cardiac function with therapy. TRED-HF investigated the safety and feasibility of therapy withdrawal in such patients.. Methods: 45 participants from TRED-HF, (25 - control group and 20 - therapy withdrawal group), who had cardiopulmonary exercise testing (CPET) at baseline and follow-up were included (Figure 1). Change in VE burden (number of ventricular ectopic beats per minute) during exercise between baseline and follow-up was compared between groups in the randomised phase using the Mann-Whitney test. Twenty patients in the control group had therapy withdrawn in the cross-over phase with repeat CPET at follow-up. Change in VE burden amongst these patients was compared between the control and cross-over phases using the paired samples sign test. Correlation between change in VE burden and changes in left ventricular ejection fraction (LVEF), NT-pro-BNP and peak VO2 was examined using Spearmans correlation. Baseline ...
No evaluation of the carcinogenicity of lynoestrenol could be made. In humans, oral contraceptives containing oestrogens in combination with progestins have been related causally to an increased incidence of benign liver adenomas and a decreased incidence of benign breast disease. Subsequent evaluation: Suppl. 7 (1987) (Progestins; combined oral contraceptives) ...
After a pill-free period of 7 days, participants took 1 oral tablet of Lyndiol® (50 μg ethinylestradiol + 2.5 mg lynestrenol) daily for a total period of at least 6 weeks to suppress endogenous gonadotropin secretion. After 3 weeks of Lyndiol® intake, participants received a single subcutaneous dose of Org 36286 15 μg ...
Changes in circulating lipoproteins, which may be related to the risk for atherosclerotic vascular disease, were studied in a control group and in two groups of 24 or 26 women using different preparations of low-dose oral contraceptives for 3 months. One preparation contained 150 μg levo-norgestrel and 30 μg ethinylestradiol (Stediril-d 150/30); the other contained 750 μg lynestrenol and 37.5 μg ethinylestradiol (Ministat). No significant changes were found with either of the preparations in serum cholesterol or high density lipoprotein cholesterol (HDL-C) levels. Apolipoprotein A-II levels increased during Ministat treatment from 50.4 to 61.4 mg/dL and during Stediril-d 150/30 treatment from 52.7 to 58.9 mg/dL (both P , 0.001). These changes differed significantly from each other (P , 0.01). Apolipoprotein A-I levels increased significantly during use of Ministat only. Apoliprotein B in low density lipoprotein increased by about 20% (P , 0.001) in both groups. Post-heparin lipoprotein ...
A kezel s v ltozik a menopausa id pontj hoz viszony tva (perimenopausa, korai vagy k s i postmenopausa). Praemenopausa: Menopausa el tti (praemenopausalis) dysfunctionalis v rz s negat v hisztol giai lelet eset n: ciklikus oralis gesztog n, pl. lynestrenol 2x5 mg 20 napig havonta, 3-6 ciklusban ism telve. Ugyanez 1-2x10 mg medroxyprogesteron acetat (MPA), vagy didrogesteron (1-2x10-20 mg) ad s val is el rhet . Folyamatos oralis gesztog n lland , vagy alacsonyabb kezd , majd n vekv d zisban 3-6 h napig, a hisztol giai leletet s/vagy a v rz szavar visszat r volt t tekintve. Az egy ni elb r l snak itt jelent s szerep jut. Menopausa el tti egy b t netek (pl. raromenorrhoea, h hull mok, stb.) is jelezhetik a fertilis id szakban viszonylag stabil petef szekciklusok zavar t, anovulati s ciklusok egyre gyakoribb v l s t, alapvet en a cs kken sztrog n- s kimaradoz progeszteron-termel st. Ezek a t netek ltal ban gy gyszeres beavatkoz st nem ig nyelnek, de igen j l befoly solhat k HPK-val s egyben el ...
Step I: In addition to continuing HAART, patients are randomized into 1 of the following 4 arms:. A: Immunization placebo; B: Immunization with the canarypox HIV-vaccine (vCP1452); C: Daily low-dose IL-2 + immunization placebo; or D: Daily low-dose IL-2 + canarypox HIV-vaccine (vCP1452). Patients on Arms A, B, C, and D receive vaccine (or vaccine placebo) injections at Weeks 0, 4, 8, and 12. Patients on Arms C and D receive IL-2 by self-injection. HAART is not provided as part of this study.. Step II: Patients on all arms (A, B, C, and D) who meet inclusion criteria advance to Step II and interrupt HAART for a minimum of 12 weeks. The efficacy of these immunological therapies will be determined by monitoring the dynamics of viral rebound upon cessation of antiviral therapy. After 12 weeks of Step II, patients whose viral load remains below 30,000 copies/ml remain on Step II, off HAART, and continue weekly viral load monitoring. Patients will not terminate Step II or resume HAART unless and until ...
Semantic Scholar extracted view of The influence of estrogenic and-or progestogenic treatment on some parameters of lipid metabolism (a controlled clinical study). by B A Samaja et al.
Results 30 patients with OSA were randomised and 26 completed the trial according to the protocol. CPAP withdrawal led to a recurrence of OSA (mean difference in change of oxygen desaturation index between groups +30.3/h; 95% CI 19.8/h,40.7/h, p,0.001) which was accompanied by a significant change in 62 exhaled features (16 metabolites identified). The panel of discriminating mass-spectral features allowed differentiation between treated and untreated OSA with a sensitivity of 92.9% and a specificity of 84.6%. ...
308 Views , Feb 11, 2019 Authors: Michael Suen, Olga Bougie, Kristina Arendas, Sukhbir Sony Singh Affliations: University of Ottawa, The Ottawa Hospital. This video demonstrates a step-wise approach to deeply infiltrating endometriosis bowel nodule.. ...
This was a 38 year old lady who came for review. Her complaints were dysuria during periods . First I will show the pictures and then discuss the case. This lady around 8 years ago underwent a medical termination of pregnancy and had a uterine rupture , which required surgical repair. Subsequently a year later…
SERONO PERGONAL PRODUCTION WILL BE REDUCED AS PURIFIED METRODIN is produced in increasing quantities, Serono said while discussing the shortage of the two fertility drugs ("The Pink Sheet" Feb. 27, In Brief). A "highly purified urinary-derived formulation" of follicle stimulating hormone "has already achieved wide and rapid acceptance in many markets throughout the world, replacing cruder gonadotropins such as Metrodin and Pergonal," Serono said.. ...
Although side effects to steroids can be serious, your child should not suddenly stop taking steroids if side effects first appear. There are many ways to manage the side effects of steroids, including changing the type of steroid taken, changing the dose, and changing the dosing schedule. Make sure your NMS tries everything to manage the side effects, and to institute these changes before steroids are discontinued. At this time, steroids are the only medicines known to help to maintain strength and function for people living with Duchenne.. If you do make the decision to stop taking steroids, it is important that you do so under the supervision of a medical provider (preferably, the prescribing medical provider) and follow the corticosteroid therapy withdrawal guidelines outlined in the PJ Nicholoff Steroid Protocol (download). Watch very carefully for signs of life-threatening adrenal crisis during the corticosteroid taper, and for one year post-taper during times of serious injury or ...
These results demonstrated that overweight type 1 diabetic subjects taking rosiglitazone experienced significant and comparable improvements in A1C levels (−1.0%) as subjects taking insulin alone (−0.7%) when insulin therapy was adjusted in both groups in an attempt to achieve near-normal blood glucose levels. However, the placebo-treated group required 11% more insulin to achieve these results. Both groups also gained significant but comparable amounts of weight (∼3 kg). This weight gain was not related to the presence of edema or change in insulin dose, and it was not associated with any increase in caloric intake based on 3-day food records. Rather, weight gain was strongly associated with improved A1C levels in both groups. By the end of the study, neither group had experienced any significant change in lipid levels, and the overall frequency of hypoglycemia was the same. The group treated with rosiglitazone experienced significantly more edema and anemia, with female sex being the ...
any ideas on how to code this: PROCEDURES: 1. Exploratory laparotomy. 2. Resection of mass of the rectovaginal septum with radical right pelvic side w
Gy gyszeres kezel sek csoportos t sa. A klinikai gyakorlatban jelenleg a k vetkez elj r sok llnak rendelkez s nkre: Az androg nhat s cs kkent se: az ovarium androg ntermel s nek visszaszor t sa: GnRH-anal gok, hormon lis antikoncipiensek, Diane-35, a mell kvese fokozott androg ntermel s vel is j r kombin lt form k eset n, a mell kvesek reg-m k d s visszaszor t sa (hydrocortison, cortison-acet t, prednisolon, dexamethason). Ovulatio-indukci : Az FSH deficientia p tl sa: clomiphen (Clostilbegyt, Serophene), FSH-k sz tm nyek (Metrodin, Metrodin HP, Gonal F, Puregon). A hypothalamus ciklusos m k d s nek beind t sa GnRH-val (Lutrelef adagol sa minipump val) nem v ltotta be a hozz f z tt rem nyeket. Az androgenisati s t netek cs kkent se: Antiandrog nek (cyproteron-acet t, flutamid, finasterid). A hyperinsulinismus cs kkent se. Fogy k r t elõseg tõ gy gyszerek. T rsbetegs gek kezel se. Az androg nhat s cs kkent se: A hyperandrogen-hat s cs kkent s re elvileg t bbf le kezel si lehet s g k n lkozik: ...
This study follows up on a previous paper by the same group from 2011 ("Is the baboon model appropriate for endometriosis studies?", F+S Sept 2011). In these articles the induction of endometriosis is demonstrated with impressive histologic, and laparoscopic images. The model holds great promise to study endometriotic lesions, including nodular lesions and their invasiveness. The caveat to the model is that the induction of endometriosis in the baboon is costly and time-consuming, as well as relatively inefficient (Induction of endometriosis in 20.7% in the 2011 study). It will also be interesting to see if the induction of endometriosis is confirmed in more detail on a molecular level. Nevertheless this model is a great addition to the experimental tools to study endometriosis.. ...
Norethynodrel: A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
Introduction: Upper Airway Stimulation is a promising treatment option for obstructive sleep apnea (OSA) patients. The primary aim of this randomized controlled trial was to determine the therapy withdrawal effect on polysomnographic (PSG) and quality of life (QOL) outcome measures.. Methods: The STAR trial enrolled participants with moderate to severe OSA. Participants with BMI , 32 and without complete concentric collapse at the retropalatal airway received an implanted neurostimulator. After the 12 month follow-up, the withdrawal effect was assessed by randomizing consecutive therapy responders to one week of therapy suspension vs. maintenance followed by a PSG, and QOL measures including Epworth Sleepiness Scale (ESS) and Functional Outcomes of Sleep Questionnaire (FOSQ). Results: In the therapy ON (Tx ON) maintenance group, all outcome measures remained unchanged at one week. In the therapy OFF (Tx OFF) withdrawal group, all outcome measures returned towards baseline levels after one week ...
Mestranol: …estrogens, such as estranol or mestranol (18), commonly used in oral contraceptives and for other therapeutic purposes, have acetylenic (containing triple bonds between carbon atoms) substituents. Nonsteroidal synthetic estrogens-e.g., diethylstilbestrol (19) and related compounds-are used clinically and also in animal husbandry to promote fattening of livestock and poultry and to…
Physician reviewed mestranol and norethindrone patient information - includes mestranol and norethindrone description, dosage and directions.
The RAD50 gene is associated with an increased risk for autosomal dominant breast, ovarian, and possibly other cancers in individuals who carry a single pathogenic variant. Additionally, the RAD50 gene has preliminary evidence supporting a correlation with autosomal recessive Nijmegen breakage syndrome-like disorder (NBSLD) (MedGen UID: 442700).
New HIV trial will begin in South Africa, in the attempt to diminish and even eradicate this disease. The subjects taking part in this trial will be monitored for two years after being administered the medication.
Nandrolone decanoate Nandrolone decanoate CAS: 360-70-3 Nandrolone decanoate Alias: Deca-Durabolin;19-Nortestoterone decanoate Nandrolone decanoate MF: C28H44O3 Nandrolone decanoate MW: 428.65 Nandrolone decanoate Properties:white to light yellow...
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Nandrolone decanoate, sold under the brand name Deca-Durabolin among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women. It is given by injection into muscle once every one to four weeks. Side effects of nandrolone decanoate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women. Nandrolone decanoate is a nandrolone ester and a long-lasting prodrug of nandrolone in the body. Nandrolone decanoate was first described in 1960 and was introduced for medical use in 1962. It was ...
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Nandrolone decanoate is an injectable form of the anabolic steroid nandrolone.The decanoate ester provides a slow release of nandrolone from the site of injection, lasting for up to three weeks. Nandrolone is very similar to testosterone in structure, although it lacks a carbon atom at the 19th position (hence its other name, 19nortestosterone). Like testosterone, nandrolone exhibits relatively strong anabolic properties. Unlike testosterone, however, its tissue-building activity is accompanied by weak androgenic properties. Much of this has to do with the reduction of nandrolone to a weaker steroid, dihydronandrolone, in the same androgen-responsive target tissues that potentate the action of testosterone (by converting it to DHT). The mild properties of nandrolone decanoate have made it one ofthe most popular injectable steroids worldwide, highly favored by athletes for its ability to promote significant strength and lean muscle mass gains without strong androgenic or estrogenic side ...
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Nandrolone Decanoate or Deca-Durabolin is an anabolic steroid similar in structure to the male hormone testosterone. Muscle Gains, Fat loss, Side effects...
Summary Safety Review - Hormone Replacement Therapy (Estrogenic and Progestogenic Agents) and Selective Estrogen Receptor Modulators (SERMs) - Assessing the Potential Risk of Ovarian Cancer
Objective: We evaluated the effects of a new combined hormonal contraceptive vaginal ring (CVR) delivering the nonandrogenic progestin Nestorone® (NES) and ethinyl estradiol (EE) on several key estrogen-sensitive hepatic proteins that may be markers for the risk of arterial or venous disease events and on blood pressure (BP). Because the pharmacologic androgenicity of the progestin in these formulations influences the hepatic impact of EE, we selected an oral contraceptive (OC) delivering the androgenic progestin levonorgestrel (LNG) and EE as the comparator. We also investigated the effect of delivery route, which is known to modify the hepatic effects of estradiol, but has not been widely studied with EE. Study Methods: Women, aged 18-34 years, with no contraindications to the use of combined OCs, were randomized to three cycles of treatment with a CVR delivering NES/EE (150/15 μg/day) or a combined OC providing LNG and EE (150/30 μg per tablet). Each cycle consisted of 21 days of active ...
1. It has been suggested that low levels of serum caeruloplasmin in Wilsons disease result from the failure to switch from a fetal to an adult mode of caeruloplasmin gene expression. To investigate postnatal expression of the caeruloplasmin gene, steady-state levels of caeruloplasmin messenger RNA in adult and neonatal rat liver were measured.. 2. Copper parameters observed in neonatal rats were similar to those seen in Wilsons disease: hepatic copper concentration was significantly elevated (neonatal 164 ± 35 μg/g, adults 50 ± 8 μg/g, P , .001) and serum copper and caeruloplasmin levels were low (neonatal 0.5 ± 0.1 μg/ml, adults 1.3 ± 0.2 μg/ml, P , .001; neonatal 0.20 ± 0.04 arbitrary units, adults 0.69 ± 0.16 arbitrary units, P , .001), respectively.. 3. Caeruloplasmin messenger RNA levels were analysed by Northern and dot blotting using a 12P-labelled caeruloplasmin complementary DNA probe. A caeruloplasmin messenger RNA of approximately 4.4 kilobases was detected in both adult ...
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CAS Number: 360-70-3 Assay: 99% Molecular Formula: C28H44O3 Molecular Weight: 428.65 Packing:25g/foil bag - Manufacturer - Producer - PSL117117YH
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Mestranol: The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.