TY - JOUR. T1 - Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. AU - Ross, Robert W.. AU - Zietman, Anthony L.. AU - Xie, Wanling. AU - Coen, John J.. AU - Dahl, Douglas M.. AU - Shipley, William U.. AU - Kaufman, Donald S.. AU - Islam, Tina. AU - Guimaraes, Alexander. AU - Weissleder, Ralph. AU - Harisinghani, Mukesh. PY - 2009/7. Y1 - 2009/7. N2 - Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on ...
4. All patients must have thorough tumor staging and meet at least one of the following criteria: a. Either lymph node biopsy or lymph node dissection demonstrating lymph node metastasis by prostate cancer; b. Non-bulky (, 5 cm) regional pelvic or distant lymphadenopathy visualized on CT/MRI scan. Lymph node biopsy is required if , 2.0 cm or in atypical distribution. c. Primary tumor Gleason score ,/= 8 and serum PSA concentration ,/=25 ng/mL, indicating high risk of occult lymph node metastases. d. Primary clinical tumor stage of T3 and Gleason score ,/= 7, indicating high risk of occult lymph node metastases. e. Primary tumor stage T4, indicating high risk of occult lymph node metastases. Patients in any of these groups and less than 3 sites of non-predominantly lytic bone metastasis will be still considered eligible for the trial. The 2010 AJCC staging system will be followed ...
Cervical cancer arises from the neck of the womb (cervix). Cervical screening programmes have decreased the rate of advanced cervical cancer. However, a significant number of cases still present with locally advanced disease that involves large cervical tumours (, 4 cm) or tumours that extend to the upper vagina. The larger the primary tumour, the greater the likelihood of metastasis (spread of cancer to other areas of the body). Cervical cancer spreads to the lymph nodes in the pelvis and around the aorta (one of the major blood vessels in the abdomen). Stage is a standardised assessment of the size of the cancer and if it has spread to adjacent or distant sites. Stage for stage, women with para-aortic lymph node metastases at presentation have a lower survival than those who do not have para-aortic metastases at presentation.. Accurate detection of involved para-aortic lymph nodes helps to tailor radiotherapy so that it includes this area (extended-field radiotherapy). It also provides ...
Para-aortic lymph node metastases are considered regional lymph nodes (Stage IIIC).. Key Points:4 stages, First 3 stages have subdivisions A,B,C.IVth stage has no sudivisions.. The ovarian cancer stages are made up by combining the TNM categories in the following manner:. ...
Tsuchiya, A.; Sugano, K.; Kimijima, I.; Abe, R., 1996: Immunohistochemical evaluation of lymph node micrometastases from breast cancer
1. Huvos AG, Hunter RV, Berg JW. Significance of axillary macrometastases and micrometastases of mammary cancers. Ann Surg 1971; 173: 44-46. 2. Diest PJ van, Peterse HL, Borgstein PJ et al. Pathological investigation of sentinel lymph nodes. Eur J Nucl Med 1999; 26(Suppl): S43-49. 3. Schreiber RH, Pendas S, Ku NN, Reintgen DS, Shons AR, Berman C, Boulware D, Cox CE. Microstaging of breast cancer patients using cytokeratin staining of the sentinel lymph node. Ann Surg Oncol. 1999; 6(1): 95-101. 4. Clare SE, Sener SF, Wilkens W, Goldschmidt R, Merkel D, Winchester DJ. Prognostic significance of occult lymph node metastases in node-negative breast cancer. Ann Surg Oncol. 1997; 4(6): 447-451. 5. Nos C, Harding-MacKean C, Freneaux P, Trie A, Falcou MC, Sastre-Garau X, Clough KB. Prediction of tumour involvement in remaining axillary lymph nodes when the sentinel node in a woman with breast cancer contains metastases. Br J Surg. 2003; 90(11): 1354-1360. 6. Fisher ER, Swamidoss S, Lee CH, Rockette H, ...
With artificial intelligence, computers learn to do tasks that normally require human intelligence. A new study in JAMA reports on how accurate computer algorithms were at detecting the spread of cancer to lymph nodes in women with breast cancer compared with pathologists video.
Powell, Arfon, Wheat, Jenni, Karran, Alexandra, Blake, Paul A., Chan, David S., Escofet, Xavier, Havard, Timothy, Blackshaw, Guy, Clark, Geoff, Christian, Adam and Lewis, Wyn G. 2015 ...
Hyung, W.Jin.; Noh, S.Hoon.; Yoo, C.Hak.; Huh, J.Hun.; Shin, D.Woo.; Lah, K.Hyeok.; Lee, J.Ho.; Choi, S.Ho.; Min, J.Sik., 2002: Prognostic significance of metastatic lymph node ratio in T3 gastric cancer
Development and validation of web-based nomograms for predicting lateral lymph node metastasis in patients with papillary thyroid carcinoma
TY - JOUR. T1 - Keratinization and necrosis. T2 - Morphologic aspects of lymphatic metastases in ultrasound. AU - Mäurer, Jürgen. AU - Willam, Carston. AU - Steinkamp, Herrmann J.. AU - Knollmann, Friedrich D. AU - Felix, Roland. PY - 1996/9. Y1 - 1996/9. N2 - RATIONALE AND OBJECTIVES. The authors performed a retrospective study in ultrasound to investigate new aspects in the sonomorphology of lymph node metastases of the neck. In this study, it could be demonstrated the first time that the histologic characteristics of the metastases determine the sohographic appearance. In addition to criteria such as the longitudinal/transversal quotient, sonomorphology could support a more precise differential diagnosis of neck lymph nodes. METHODS. In 105 of 145 patients with histologically proved head and neck carcinomas, 187 lymph node metastases were detected by ultrasound. Sohomorphology was compared with the corresponding histology. RESULTS. Five sohomorphologic groups could be differentiated. (1) ...
There are few data on the long-term outcome of patients with microinvasive (T1mi) breast cancer. Moreover, predictors of lym ph node involvement and the im pact of multifocal microinvasion are not wel
(HealthDay)-Lymph node metastases are more common in breast cancers with mutations in a cellular signaling pathway associated with growth, according to a study published online July 24 in JAMA Surgery.
In patients with advanced ovarian cancer (FIGO stage III-IV), a percentage between 50% and 80% had lymph node metastases at diagnosis, mainly in para-aorto-caval (48 %) and iliac areas (49%). In 1988, FIGO has included lymph node metastasis in stage IIIC, although some authors argue that only node involvement constitutes a clinical course different from IIIC cancer patients with abdominal diffusion.. Although it has been demonstrated that lymphadenectomy is technically feasible and relatively safe in this subset of patients, however, it is burdened by a certain percentage of complications including limphocyst, lymphedema, hemorrhage, ranging from 6% to 45%. In addition, the actual therapeutic role is still controversial and it is not clear whether this surgical procedure should be part of the staging of these tumors. Retrospective studies have shown a benefit on overall survival in patients with ovarian cancer who underwent lymphadenectomy associated with optimal debulking (residual tumor ,1 ...
OBJECTIVE: The aim of this study was to assess the relationship between fluorine-18 fluorodeoxyglucose (F-FDG) uptake and molecular biological markers in esophageal squamous cell carcinoma (ESCC) … patients. METHODS: Our patient population included 51 patients who underwent F-FDG PET/computed tomography before surgery. Excised tumor tissue was analyzed immunohistochemically using monoclonal antibodies for glucose transporter-1 (GLUT-1), GLUT-3, CD34 [microvessel density (MVD) marker], CD68 (macrophage marker), and CD163 (tumor-associated macrophage marker). The relationships among pathological factors [pathological T stage (p-T stage), pathological lymph node status (p-N status), pathological stage (p-stage), and pathological tumor length], the maximum standardized uptake value (SUVmax), and these molecular biological markers were evaluated using Spearmans rank test and the Kruskal-Wallis test. RESULTS: GLUT-1, GLUT-3, CD34, and CD163 significantly correlated with SUVmax (r=0.547, P,0.001 for ...
The most common cause of a hypoechoic mass along the carotid arteries is an enlarged lymph node. The aspect of the lesion between the carotid arteries with encasement of the vessels and the irregular hypervascularity are atypical for a pathological lymph node ...
Prognostic significance of perigastric lymph nodes metastases on survival in patients with thoracic esophageal cancer (pages 40-45). Zhi-Yong Wu, Jun-Cai Yu, Li-Yan Xu, Jin-Hui Shen, Jian-Zhong Wu, Shao-Hong Wang, Jun-Hui Fu, Yang-Hang Fan, Bin-Na Yang, Zhong-Ying Shen, Qiao Huang and En-Min Li. Version of Record online: 15 APR 2009 , DOI: 10.1111/j.1442-2050.2009.00964.x. ...
Invasive cancer confined to the original anatomic site of growth without lymph node involvement. The definition of stage IB depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IB is defined as follows: (T0, N1mi, M0); (T1, N1mi, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. N1mi: Nodal micrometastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IB is defined as follows: (T2, N0, M0, G1, G2, GX); (T3, N0, M0, G1, G2, GX). T2: Tumor more than 8 cm in greatest dimension. T3: Discontinuous tumors in the primary bone site. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated-low grade. G2: Moderately differentiated-low grade. GX: Grade cannot be assessed. (partially adapted from AJCC 7th ed.)
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Answers from specialists on cin 3. First: Breast cancer survival is correlated with its stage, which is predominantly based on the cancer size, its growth, and lymph node involvement. Stage 3 means that the cancer has grown into the chest wall or skin and/or multiple lymph nodes (including areas outside the armpit) are involved. These are all signs that chemotherapy is needed for potential cure.
Recently, based on surgical data, extended indications for EMR have been proposed (Table 1). After an analysis of the results of 5,265 patients who underwent gastrectomy with LN dissection, Gotoda et al.4,19 and An et al.20 reported the lesion that meets these criteria has no or minimal risk of LN metastasis: 1) no size limitation for intramucosal differentiated cancers without ulceration that have no lymphovascular invasion, 2) less than 3 cm in diameter for ulcerated differentiated intramucosal cancers without lymphovascular invasion, 3) less than 3 cm in diameter for differentiated cancers (extension into the submucosal for less than 500 micrometers) without lymphovascular invasion, 4) less than 2 cm in diameter for undifferentiated intramucosal cancers without ulceration. Currently, the extended criteria for ESD are in use in Japan.. However, there are several issues to consider with the extended indications. The first issue is the risk of LN metastasis. In a Korean study, 855 patients who ...
Lymphoma can involve any lymph node. It can involve single or multiple lymph nodes forming mass. Extra nodal involvement can also be observed.
rs438034 is a SNP in the centromere protein F CENPF gene. Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99). [PMID 19008095] ...
pN0(mol+): No regional lymph node metastasis histologically, positive nonmorphologic (molecular) findings for isolated tumor cells (breast) (finding ...
The mutant allele-specific amplification (MASA) method is capable of detecting one tumor cell containing genetic changes in a sample containing thousands of normal cells. To investigate whether MASA can be applied to sensitive detection of lymph node metastasis, we screened 22 colorectal cancers for K-ras and p53 mutations and examined corresponding regional lymph node at the genetic level by the MASA method. Six of the primary tumors were found to certain K-ras mutations, and nine exhibited mutations of the p53 gene. In seven of the 14 cases in which genetic alterations were identified (mutations in both genes were found in one tumor), we found discrepancies between the genetic and the histopathological diagnoses with respect to the presence or absence of cancer cells in lymph nodes, in that these patients were histologically diagnosed lymph node negative, hn(-) but genetically diagnosed lymph node positive, gn(+). Because disease recurs in 20-30% of cancer patients whose lymph nodes are ...
Introduction To decipher the interaction between the molecular subtype classification and the probability of a non-sentinel node metastasis in breast cancer patients with a metastatic sentinel lymph-node, we applied two validated predictors (Tenon Score and MSKCC Nomogram) on two large independent datasets. Materials and Methods Our datasets consisted of 656 and 574 early-stage breast cancer patients with a metastatic sentinel lymph-node biopsy treated at first by surgery. We applied both predictors on the whole dataset and on each molecular immune-phenotype subgroups. The performances of the two predictors were analyzed in terms of discrimination and calibration. Probability of non-sentinel lymph node metastasis was detailed for each molecular subtype. Results Similar results were obtained with both predictors. We showed that the performance in terms of discrimination was as expected in ER Positive HER2 negative subgroup in both datasets (MSKCC AUC Dataset 1 = 0.73 [0.69-0.78], MSKCC AUC Dataset 2
Background Lymph node metastasis is a key event in the progression of breast cancer. Therefore it is important to understand the underlying mechanisms which facilitate regional lymph node metastatic progression. Methodology/Principal Findings We performed gene expression profiling of purified tumor cells from human breast tumor and lymph node metastasis. By microarray network analysis, we found an increased expression of polycomb repression complex 2 (PRC2) core subunits EED and EZH2 in lymph node metastatic tumor cells over primary tumor cells which were validated through real-time PCR. Additionally, immunohistochemical (IHC) staining and quantitative image analysis of whole tissue sections showed a significant increase of EZH2 expressing tumor cells in lymph nodes over paired primary breast tumors, which strongly correlated with tumor cell proliferation in situ. We further explored the mechanisms of PRC2 gene up-regulation in metastatic tumor cells and found up-regulation of E2F genes, MYC targets
The purpose of this retrospective study was to analyze the distribution of lymph node metastases, including micrometastases, according to the location of the gastric cancer with submucosal invasion. A total of 118 patients with submucosal gastric cancer were enrolled in this study. The distribution of lymph node metastases was examined according to tumor location. Immunohistochemical examination using anti-cytokeratin antibody was performed to examine nodal micrometastases in 118 patients. Lymph node metastasis was found in 19.5% (23/118) of the patients. Significant differences were found for tumor size and depth, lymphatic invasion, and venous invasion for patients with and without nodal metastasis. The distribution of lymph node metastasis for tumors at upper or middle portions of the stomach was mainly found along the left gastric artery. The distribution of lymph node metastasis for tumors in the lower and lesser curvature varied. Immunohistochemical analysis found that 15 of 23 patients ...
The present study showed that the detection rate of metastatic lymph nodes in BCa patients increased with advancing T stage. Lymph nodes with the short-axis diameter of , 3.0 mm were rarely seen on CT and/or MRI. The characteristic imaging signs such as the fatty hilum of lymph node and the ratio of short/long-axis diameter ≤ 0.4 were usually found in non-metastatic lymph nodes, while spiculate margin and necrosis were commonly observed in metastatic lymph nodes. Besides, the cutoff value of short-axis diameter was 6.8 mm in the CT/MR evaluation of lymph node metastasis in patients with BCa.. A previous study reported that the rate of lymph node metastases in patients with BCa who underwent radical cystectomy was about 27% [9]. In the present study, this rate was lower (24.6%), which may be related to the early detection and treatment. With stage advancing, the rate of lymph node metastasis increased gradually. This finding was supported by other studies [10, 11]. The metastatic lymph nodes in ...
Results-Most benign lymph nodes were slightly darker or the same in brightness compared with surrounding tissue, whereas most metastatic nodes were obviously darker. The mean area ratio of benign lymph nodes ± SD (1.05 ± 0.15) was statistically lower than the mean area ratio of metastatic lymph nodes (1.39 ± 0.20; P , 0.001). The area ration cutoff level for metastatic lymph nodes was estimated to be 1.16. With the use of a receiver operating characteristic curve with this cutoff value, the area ratio predicted malignancy with sensitivity of 91.1%, specificity of 83.3%, and an area under the curve of 0.925. ...
The objectives of this assessment were to evaluate the diagnostic accuracy, cost-effectiveness and effect on patient outcomes of positron emission tomography (PET), with or without computed tomography (CT), and magnetic resonance imaging (MRI) in the evaluation of axillary lymph node metastases in patients with newly diagnosed early-stage breast cancer. PET and MRI are assessed firstly as a replacement for SLNB or 4-NS, and secondly as an additional test prior to SLNB or 4-NS. ...
Author: DrBicuspid Staff. PET/MRI outperformed diffusion-weighted MRI (DWI-MRI) for detecting lymph node metastases in the staging of head and neck cancer patients, according to a study presented November 25 at the Radiological Society of North America (RSNA) annual meeting in Chicago.. Researchers from the University of Düsseldorf found that PET/MRI achieved accuracy of 93%, compared with 88% for DWI-MRI. PET/MRI also reached sensitivity of 72%, compared with 36% for DWI-MRI.. Lymph node status has prognostic value in head and neck cancer because patients with metastases need neck dissection and adjuvant treatment. Therefore, precise lymph node staging is a necessity, noted lead author Christian Buchbender, MD.. "Currently available imaging modalities are restricted in their diagnostic performance for lymph node metastases detection," he added. "For example, CT and MRI fall short in sensitivity when compared to FDG-PET or FDG-PET/CT. On the other hand, FDG-PET/CT suffers from a large amount of ...
To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. The receiver operating characteristic (ROC) curve was used to determine the cutoff of the MLR, and CK20 immunohistochemical staining was used to detect micrometastasis of the lymph nodes. The areas under the ROC curve of MLR used to predict the death of 3-year and 5-year postoperative patients were 0.826 ± 0.053 and 0.896 ± 0.046. Thus MLR = 30.95% and MLR = 3.15% were designated as cutoffs. The MLR was then classified into three groups: MLR1 (MLR|3.15%); MLR2(3.15% ≤ MLR ≤ 30.95%); and MLR3 (MLR|30.95%). We found that patients with a higher MLR demonstrated a much poorer survival period after radical operation than those patients with a lower MLR (P = 0.000). The COX model showed that MLR was an
Semantic Scholar extracted view of [Cervical lymph node metastases in epithelial neoplasms of the upper respiratory-digestive tract]. by Chiara Cavina et al.
February 2, 2010 - When doctors added contrast agent gadolinium during magnetic resonance imaging (MRI) they improved primary tumor assessment for detecting lymph node metastases, according to a new study published online February 1, 2010, in the Journal of the National Cancer Institute. Gadolinium-enhanced MRI is primarily used to visualize primary tumors, highlight tumor vascularity, and increasingly to detect and evaluate lymph node metastases. Based on their findings the authors recommend that contrast highlighting be included as a malignancy criterion when this agent is used for primary tumor visualization.. Wenche M. Klerkx, M.D., Ph.D., department of gynecology and obstetrics, University Medical Centre Utrecht, the Netherlands, and colleagues searched the literature for studies that compared the diagnostic accuracy of gadolinium-enhanced MRI for staging lymph node metastases with that of histopathologic examination. The researchers conducted a meta-analysis on more than 30 studies from ...
The presence of lymph node metastases at the time of prostate cancer diagnosis has significant implications for treatment. According to current guidelines from the National Comprehensive Cancer Network, men with positive lymph nodes on initial staging imaging should be offered treatment with androgen deprivation (± abiraterone) along with consideration for external beam radiation therapy [1]. In contrast, men with clinically localised high‐ or very‐high‐risk prostate cancer have the option of undergoing radical prostatectomy. Unfortunately, currently available diagnostic imaging modalities (i.e. contrast‐enhanced CT and MRI) fall short in their ability to accurately identify lymph node metastases, which are often small and difficult to discern from other structures within the pelvis. Thus, there exists a conundrum: if we cannot accurately detect lymph node involvement, how can we appropriately manage it?. In this edition of the BJUI, Leeuwen et al. [2] report on the utility of molecular ...
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at di …
If you feel that you are having some swollen lymph nodes but do not know how to have them treated or what is it about, then this article can help you run through that. These lymph nodes are often found in different areas such as the groin, your armpit, your neck (there are a couple of nodes found at the front of your neck, on both sides and at the lower back of your neck), under the chin and your jaw, behind the ears and even at the back of your head. Some of the reason why they can be swollen are infections of the ear, tonsils, and skin; inflammation due to impacted tooth, mouth sores and gingivitis, colds and flu, viral illness, sexually transmitted diseases, tuberculosis, mononucleosis and even cancer.. Some swollen lymph nodes are common that they go away after a few days, but be careful not to overlook your nodes if it has become swollen for weeks now. It is best to go consult your doctor if your lymph nodes are getting redder and feels tender. If they are harder than usual, quite irregular ...
The treatment of high-risk prostate cancer (HRPCa) is a tremendous challenge for uro-oncologists. The identification of predictive moleculobiological markers allowing risk assessment of lymph node metastasis and systemic progression is essential in establishing effective treatment. In the current study, we investigate the prognostic potential of miR-205 in HRPCa study and validation cohorts, setting defined clinical endpoints for both. We demonstrate miR-205 to be significantly down-regulated in over 70% of the HRPCa samples analysed and that reconstitution of miR-205 causes inhibition of proliferation and invasiveness in prostate cancer (PCa) cell lines. Additionally, miR-205 is increasingly down-regulated in lymph node metastases compared to the primary tumour indicating that miR-205 plays a role in migration of PCa cells from the original location into extraprostatic tissue. Nevertheless, down-regulation of miR-205 in primary PCa was not correlated to the synchronous presence of metastasis and failed
Results An average of 13.8 lymph nodes were removed. 45 patients (57.7%) had a positive lymph node status, with a mean of 3.2 involved nodes per patient. 1, 5 and 10-year OS for N+ status was 60%, 10% and 10%, while N- OS was 82%, 41% and 41% (p=0.000). Similarly, 1, 5 and 10-year DFS was worse in the N+ group (71%, 45% and 42%) compared to N- (91%, 65% and 60%) (p=0.045). There was no difference in 1, 5 and 10-year OS (70%, 23%, 20% vs 70%, 23% and 20%, p=0.690) and DFS (78%, 48% and 48% vs 82%, 58% and 58%, p=0.305) when ,10 nodes were removed (n=39) compared to ≥10 nodes (n=36). There was no difference in 1, 5 and 10-year OS (63%, 9% and 9% vs 60%, 10% and 10%, p=0.562) and DFS (78%, 40% and 40% vs 65%, 46% and 40%, p=0.795) when LNR ,0.25 (n=22) was compared to LNR ,0.25 (n=23). No difference was found when a cut-off of 15 total excised lymphnodes and LNR of 0.50 was used. ...
We identified a total of 127 patients. Sixteen patients (13%) had right upper lobar lymph node metastasis. The mTLG values of pathological node metastasis were higher than in the node negative group (p = 0.04). When using a cut-off value obtained on the ROC curve, nine of sixteen cases were positive (sensitivity: 56%, specificity: 89%). The node positive cases with less than the cut-off value were a case of small cell carcinoma, four cases with EGFR mutation, a case with HER2 mutation, and a case with K-ras mutation. The values of AUC for several other examinations were mTLG: 0.76, TLG: 0.64, SUVmax: 0.66, minor axis of lymph node on HRCT: 0.70, major axis of tumor on HRCT (lung window): 0.61, major axis of tumor on HRCT (mediastinal window): 0.71 and CEA: 0.29. ...
The median p53 and MIB-1 indices were 45.2% and 30.3%, respectively. The median follow-up was 4.5 years (range, 0.1-10 years). There were no statistically significant associations noted between the p53 and MIB-1 indices and the outcomes studied. When the analysis was limited to patients who were treated with adjuvant chemotherapy (n = 37 patients), the p53 index was found to have no prognostic value; however, there was a significant association between MIB-1 and distant metastases (P = 0.049). When disease-specific survival rates were stratified according to p53 index and chemotherapy, patients exhibited a response to chemotherapy regardless of p53 index. ...
Pelvic and paraaortic lymph node evaluation is a major component of the surgical staging procedure for several gynecologic malignancies, including endometrial and ovarian carcinoma. Cervical cancer is clinically staged, but assessment of pelvic and p
Introduction: Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to retrospectively explore the prognosis and predictive values of TP53 somatic mutations in the BIG 02-98 randomized phase III trial in which women with node-positive breast cancer were treated with adjuvant doxorubicin-based chemotherapy with or without docetaxel. Methods: The prognostic and predictive values of TP53 were analyzed in tumor samples by gene sequencing within exons 5 to 8. Patients were classified according to p53 protein status predicted from TP53 gene sequence, as wild-type (no TP53 variation or TP53 variations which are predicted not to modify p53 protein sequence) or mutant (p53 nonsynonymous mutations). Mutations were subcategorized according to missense or truncating mutations. Survival analyses were performed using the ...
A variety of factors go in to the staging of a head and neck cancer diagnosis, however, the number of malignant lymph nodes may very well be the key to prognosis and treatment moving forward in this patient population.|br /|  
Cherubism is a rare benign (non-neoplastic) hereditary condition of childhood, which is inherited as an autosomal dominant trait and is characterized by bilateral expansion of the mandible, maxilla or both. Giving them a characteristic cherubic appearance. The treatment of cherubism is still controversial and is said that the disease regresses itself and after regressing if any asymmetry is left then the bony deformity can be corrected by decortications of bone and osseous shaving. This article reviews the recent development in the literature of cherubism ...
The axillary lymph nodes are the ones that are most likely to drain the area of your breast that has a tumor, even though there are other lymph nodes both in your breast and closer to your breastbone. If the tumor has sloughed off waste cancer cells, the axillary lymph nodes have probably collected them. Testing these lymph nodes for cancer is one way to determine how aggressive the tumor is and whether the cancer cells have begun to travel to other parts of the body.. There are approximately 20 lymph nodes in two clumps in each armpit. Half of them are called Level 1 (the easiest to get to) and the other group is called Level 2. There are additional lymph nodes under the collarbone, and more on either side of the breastbone, but these are rarely removed in surgery. Unfortunately, surgeons cant remove lymph nodes, test them for cancer, and put back the ones that do not have traces of cancer. In fact, they usually cant even see lymph nodes because they are so small. Surgeons usually remove a ...
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Triple negative breast cancers (TNBC) lacking hormone receptors (ER, PR) and HER-2 amplification are very aggressive tumors. The IIB-BR-G cell line isolated from a primary TNBC, and its spontaneous metastatic variant, IIB-BR-G-MTS6 were compared using an antibody-based protein array to characterize their expression profile. We also analyzed their growth kinetics, migration, invasiveness, lymphangiogenesis and cytoskeleton structure. Doubling times in vitro were shorter for IIB-BR-G although in vivo IIB-BR-G-MTS6 tumors grew significantly faster than IIB-BR-G. IIB-BR-GMTS6 showed higher anchorage independent growth in a clonogenic assay. IIB-BR-G-MTS6 cells showed 100% incidence of lymph node metastasis at 5-6 weeks, although no metastasis was observed for IIB-BR-G even 19 weeks after inoculation. CCL3, IL1α, CXCL1, CSF2, CSF3, IGFBP1, IL1α, IL6, IL8, CCL20, PLAUR, PlGF and VEGF were strongly up-regulated in IIB-BR-G-MTS6 compared to IIB-BR-G, while CCL4, ICAM3, CXCL12, TNFRSF18, FIGF, were the ...
Swollen lymph node on left side of neck - Three swollen cervical lymph nodes all on left side of neck some ear pain doctor HS seen one of them says wait 2 month fbc normal should I be worried? Lymph nodes. The lymph nodes usually enlarge as response to an infection in the vicinity. It lasts maximum 2-3 weeks and as the infection goes away (with antibiotics usually) the lymph nodes disappear. Outside this scenario, I would be worried and demand further investigation (ct is appropriate, a blood smear and CBC with differential, as well as a bmp with enzymes markers analysis) up to an excision biopy.