FIGURE 9. FRH-augmented cell death is not mediated by a soluble factor. A, The media of MLE-15 cells exposed to TNF-a and various incubation temperatures for 18 h was collected and transferred to MLE-15 cells and then incubated at 37˚C for 18 h. No difference in the cell survival at each conditioning dose of TNF-a exists, although a trend for increased mortality from the cell-conditioned media of cells at 34˚C exists. This reflects increased production (B) of and increased stability (C) of the TNF-a at 34˚C compared with 39.5˚C. - Epithelial Apoptosis a Mechanism of Enhanced Alveolar Lipopolysaccharide-Induced Lung Injury by Febrile-Range Hyperthermia Augments
PHILADELPHIA, March 11, 2013 /3BL Media/ - Once the initial episode of influenza has passed, the chronic effects tend to be overlooked. The results of a new study indicate that the cytokine interleukin-22 (IL-22) plays a critical role in normal lung repair following influenza infection. This study is published in the April 2013 issue of The American Journal of Pathology.. "With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance," says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. "A key finding is that even after the resolution of ...
Unlike Hills criteria, the US Surgeon General Expert Committee suggested to consider alternative explanations as a causality criteria. First of all, the possibility of fungi as a cause of lung injury. Although there were no other significant risk factors than HDs in the studies of lung injury, the first epidemiological study showed significant association between fungi at room reported by questionnaire administration with lung injury, even after adjustment for various variables [12]. Association with fungi was substantially small compared to association with the HDs; in addition, there was no consistency of results, as there was no significance in the analysis of different control groups. Furthermore, fungi were not detected in the patients specimen. Above all, there was no significant association between fungi and lung injury among the study in children and community-based case control study [12,13]. Thus, the possibility that fungi may be a direct cause of lung injury is very low, and it is ...
While legal challenges form just one half of the effort to curb vaping-related injuries, medical providers are striving to better characterize and treat these illnesses. Such research is hampered by the unknown root cause of lung injury. Initial onset of vaping-related lung injuries can be hard to identify, with symptoms including fever, abdominal pain, and diarrhea. Later onset of respiratory injuries is also expected in the form of these vaping-associated lung injuries, which may include coughing, nausea, watery diarrhea, and chest or abdominal pain. Yet, over 1,000 cases of vaping associated-lung injury have been reported without a specified cause since June 2019. In response to this ongoing outbreak, the Utah Department of Health conducted a case study to describe the correlation between vape use and associated lung injuries. They found that individuals who used e-cigarettes with THC cartridges, the active ingredient in marijuana, experienced disproportionately greater hospitalization and ...
The CDC recently announced some updates regarding lung diseases linked to use of vaping devices. If you were injured contact Elliott & Smith Law.
Cases of lung injuries in Stamford and Connecticut are similar to reports around the country involving e-cigarettes containing THC exclusively, a combination of nicotine and THC, or just nicotine, that have caused similar symptoms. However, the CDC found that the vast majority of lung injuries due to vaping come from cartridges that contain THC, which is the principal psychoactive component of cannabis.. ...
Currently, ALI and ARDS therapy focuses on the lungs to maintain gas exchange and minimize further injury. These researchers examined rats with lung injury and determined that the brain regions that control breathing are affected also. In fact, the characteristics of the pathologic breathing pattern remain even when the lungs are removed. In addition, inflammation was evident in the part of the brain that generates the breathing pattern. This indicates that the lungs are not the only factor involved in breathing disorders in lung injury ...
The Centres for Disease Control and Preventions (CDC) has updated its interim guidance for the evaluation and management of patients with suspected e-cigarette, or vaping-associated, lung injury (EVALI), based on the 1,299 cases reported as of October 8, 2019. The chemical(s) responsible for the lung injury have not yet been identified (Tetrahydrocannabinol or THC-containing
Lung injuries from vaping have been reported in all 50 states. Health officials have reported 52 deaths nationwide due to vape lung injury.
As of December 17, there were 2,506 hospitalized cases of lung injury linked to vaping in the United States, the US Centers for Disease Control and Prevention s...
E-cigarette use can harm the lungs. Eight Wisconsin teens who developed severe lung injuries after vaping may be the latest victims.
Hundreds more Americans have been sickened by a mysterious vaping-related lung disease, and the death toll has risen to 18, according to federal health data released Thursday.
A balancing act between transcriptional activators and repressors appears to play a key role in maintaining tissue homeostasis....
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A pulmonary contusion, also known as lung contusion, is a bruise of the lung, caused by chest trauma. As a result of damage to capillaries, blood and other fluids accumulate in the lung tissue. The excess fluid interferes with gas exchange, potentially leading to inadequate oxygen levels (hypoxia). Unlike pulmonary laceration, another type of lung injury, pulmonary contusion does not involve a cut or tear of the lung tissue. A pulmonary contusion is usually caused directly by blunt trauma but can also result from explosion injuries or a shock wave associated with penetrating trauma. With the use of explosives during World Wars I and II, pulmonary contusion resulting from blasts gained recognition. In the 1960s its occurrence in civilians began to receive wider recognition, in which cases it is usually caused by traffic accidents. The use of seat belts and airbags reduces the risk to vehicle occupants. Diagnosis is made by studying the cause of the injury, physical examination and chest ...
TY - JOUR. T1 - Effect of phorbol myristate acetate-induced lung injury on airway blood flow. AU - Barman, Scott A. AU - Ardell, J. L.. AU - Taylor, A. E.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The effects of phorbol myristate acetate (PMA) induced lung injury on the pulmonary and systemic blood flow contributions to the trachea and main bronchi (upper airways) were assessed in anesthetized dogs by injecting 15 μm radiolabeled microspheres into the right and left heart, respectively. Upper airway blood flow was studied in lungs given the following treatments: (1) PMA; (2) PMA in lungs pretreated with the thromboxane synthetase inhibitor OKY-046, and (3) PMA in lungs pretreated with the antioxidant catalase. After microsphere injections, the tracheal cartilage, tracheal muscle-mucosa, and main bronchi were excised. The results of this study indicate that under normal conditions, tracheal mucosa [33-52 ml·min-·(100 g)-1] and tracheal cartilage [18-27 ml·min-1·(100 g)-1] blood flow is primarily ...
Inflammation is involved in the pathogenesis of seawater aspiration-induced acute lung injury (ALI). Although several studies have shown that Semaphorin 7A (SEMA7A) promotes inflammation, there are limited reports regarding immunological function of SEMA7A in seawater aspiration-induced ALI. Therefore, we investigated the role of SEMA7A during seawater aspiration-induced ALI. Male Sprague-Dawley rats were underwent seawater instillation. Then, lung samples were collected at an indicated time for analysis. In addition, rat pulmonary microvascular endothelial cells (RPMVECs) were cultured and then stimulated with 25% seawater for indicated time point. After these treatments, cells samples were collected for analysis. In vivo, seawater instillation induced lung histopathologic changes, pro-inflammation cytokines release and increased expression of SEMA7A. In vitro, seawater stimulation led to pro-inflammation cytokine release, cytoskeleton remodeling and increased monolayer permeability in pulmonary
Medical information, Acute lung injury. Definition of Acute lung injury, symptoms of Acute lung injury, treatment of Acute lung injury, and prevention of Acute lung injury. Exams and Tests Acute lung injury.
Objective:Although ventilation with small tidal volumes is recommended in patients with established acute lung injury, most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury, which develops after the in
The report titled, "Acute Lung Injury Treatment Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017 - 2025" by TMR Research furnishes an in-depth analysis of the vital catalysts and deterrents of the global market for acute lung injury treatment, alongside accurate figures, charts, diagrams, and graphs. The report offers an insightful assessment of the leading geographical segments and the growth opportunities offered by each of them. Acute lung injury is a prominent cause of morbidity and mortality across the world. Since one of the common conditions that is associated with severe hypoxia is acute lung injury, acute lung injury treatment market is expected to soar as its incidence keeps escalating worldwide, augmenting mortality rates. Researchers can now have access to critical information pertaining to the pathophysiology of the condition as well as numerous biological markers related to worse clinical outcomes of patients, thanks to the recent technological ...
Comment on Assessment of Aspiration-Induced lung Injuries among Acute Drug Poisoning Patients; Loghman Hakim Hospital, Poisoning center
Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell infiltration, activation and inflammatory cytokine release, enhancing basal alveolar fluid clearance and improving alveolar capillary barrier function.The Beta Agonist Lung Injury TrIal (prevention) is a multi-centre, randomised, double blind, placebo-controlled trial. The aim of the trial is to determine in patients undergoing elective transthoracic oesphagectomy, if treatment with inhaled salmeterol 100 mcg twice daily started at induction of anaesthesia and continued for 72 hours thereafter compared to placebo affect the incidence of early acute lung injury and other clinical, resource and patient focused outcomes. The primary outcome will be the development of acute lung injury within 72 hours of oesophagectomy. The trial secondary outcomes are the development of acute
GlobalDatas clinical trial report, Acute Lung Injury Global Clinical Trials Review, H2, 2012 provides data on the Acute Lung Injury clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Acute Lung Injury. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Acute Lung Injury. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts. Note: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.
BACKGROUND: Platelet-activating factor is a mediator of lung injury during cardiac operation. Platelet-activating factor antagonists reduce lung injury in animal models of cardiopulmonary bypass but there is no confirmatory evidence in clinical practice. METHODS: The effect of a low or high dose of a platelet-activating factor antagonist (Lexipafant) was assessed in a single center, double-blind, placebo-controlled, parallel group study. One hundred fifty patients undergoing coronary artery bypass grafting were randomized by minimization into three groups to receive placebo infusion, 10 or 100 mg of lexipafant for over 24 hours. Serial arterial oxygen and carbon dioxide tension, alveolar arterial oxygen gradient, and percent saturation were measured before operation and at 1, 6, 24, 48 hours, and 5 days after operation. RESULTS: Patient groups were similar with respect to age, sex, body surface area, and urgency of operation. Likewise, the groups were similar with respect to duration of cardiopulmonary
Ventilator-induced lung injury (VILI) contributes to mortality in ARDS. Particularly preinjured lungs are susceptible to VILI despite protective ventilation. We previously observed protection against VILI by Adrenomedullin (AM). Here we analyzed impact VILI on lung injury, pulmonary and systemic inflammation, bacterial burden and end-organ injury in established pneumonia. Further AM therapy was investigated.. 24h after infection with S. pneumoniae mice were subjected to MV (12ml/kg, 6h) and AM treatment. Lung permeability, oxygenation, lung mechanics, lung and plasma cytokines and leukocytes, bacterial burden in lung, blood spleen, ALT, AST, creatinine and urine output were assessed. Expression of AM and its receptor complex (CRLR; RAMP1-3) were studied. In pneumonia MV aggravated lung injury indicated by increased pulmonary permeability, oxygenation failure and worsening of lung mechanics. MV dramatically increased lung and blood cytokine levels in pneumonia, while lung leukocyte counts in ...
Cerrar Maskara S Sen N et al. Correlation between lung injury score and serum albumin levels in patietns at risk for developing acute lung injury. Nutrition. 2000; 16: 91-94 ...
With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance," says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Childrens Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. "A key finding is that even after the resolution of infection, influenza results in lung parenchymal remodeling that may be critical to susceptibility to further injury," says Dr. Alcorn. This series of experiments used 6- to 8-week-old wild-type (WT) mice (C57BL/6 strain) as well as IL-22-deficient mice, infected with influenza A PR/8/34 H1N1 or control vehicle. To determine the distribution of IL-22 in the lung, they used ...
Expression analysis, microscopy, chromatin immunoprecipitation, electrophoretic mobility shift assays, and VE-cadherin-luciferase reporter experiments demonstrated that KLF4 interacted with specific domains of VE-cadherin promoter and regulated the expression of VE-cadherin at AJs. KLF4 knockdown disrupted the endothelial barrier, indicating that KLF4 is required for normal barrier function. In vivo studies in mice showed augmented lipopolysaccharide-induced lung injury and pulmonary edema following Klf4 depletion.. ...
Anti-inflammatory effects of methanol extract of Canarium lyi C.D.Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury / Ju Mi Hong; Ok-Kyoung Kwon; In Sik Shin; Chan Mi Jeon; Na Rae Shin; Joongku Lee; Sang-Hong Park; T Bach; D V Hai; Sei-Ryang Oh; S B Han; Kyung Seop Ahn , 2015 ...
Invading pathogens may trigger overactivation of the innate immune system, which results in the release of large amounts of proinflammatory cytokines (cytokine storm) and leads to the development of pulmonary edema, multiorgan failure, and shock. PIAS1 is a multifunctional and potent anti-inflammatory protein that negatively regulates several key inflammatory pathways such as Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and nuclear factor κB (NF-κB). We discovered a ubiquitin E3 ligase, HECTD2, which ubiquitinated and mediated the degradation of PIAS1, thus increasing inflammation in an experimental pneumonia model. We found that GSK3β phosphorylation of PIAS1 provided a phosphodegron for HECTD2 targeting. We also identified a mislocalized HECTD2 polymorphism, HECTD2A19P, that was present in 8.5% of the population and functioned to reduce inflammation. This polymorphism prevented HECTD2/PIAS1 nuclear interaction, thus preventing PIAS1 degradation. The HECTD2A19P ...
BACKGROUND: Major burns can alter the pharmacokinetics of opiate analgesics, which are commonly used perioperatively. Fentanyl undergoes a significant amount of pulmonary pharmacokinetic transition. This study was conducted to compare the pharmacokinetics of fentanyl in major burns, with and without lung injury, during the subacute hyperdynamic phase of recovery. METHODS: Twelve adults, with total body surface area (TBSA) 51.0 +/- 11.8% burns, aged 34.9 +/- 9.6 years, with a lung injury related to the burn, were studied at 15.4 +/- 9.4 days after the injury. Another 8 patients, aged 39.8 +/- 10.5 years, with TBSA 46.3 +/- 19.4%, at 19.3 +/- 10.9 days, without lung injury, served as controls. Fentanyl 200microgram was given intravenously over 10 seconds. Blood samples (n = 20) were collected at predetermined intervals. A two-compartment model was used for pharmacokinetic analyses of the fentanyl concentrations, as determined by LC/MS. The cardiac index (CI) was also measured using an esophageal ...
Acute lung injury (ALI) is an example of a critical care syndrome with limited treatment options once the condition is fully established.Not surprisingly, many treatments targeting the mechanisms identified in preclinical studies have failed to improve patient outcomes.The most likely reason could be due to inadequate and delayed recognition of patients at risk and the subsequent development of the full blown syndrome.ALI/ARDS usually develops during the first hours of ICU admission, and often is the very reason for ICU admission.. Clinical prediction models have been extensively used in the clinical practice to identify patients at high risks who may benefit from specific interventions. However, no such tool exists to predict the development of ALI in patients at risk. We have recently developed an ALI prediction model (Lung Injury Prediction Score:LIPS)which incorporates demographic, environmental and clinical characteristics at the time of, and before, hospital admission. If validated, this ...
The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission.. Aim 1- To validate the prediction model (Lung Injury Prediction Score) in a population based sample of hospitalized patients.. Aim 2- To determine the significance of health-care related ALI risk modifiers in a population based sample.. Aim 3- To compare the short and long term outcomes between patients at high risk who do, and do not develop ALI.. ...
Introduction Although activation of A3adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine...
Aim: This study was to observe the changes of the gene expression of microRNA-155 and 127 in the neonatal rats with Acute Lung Injury (ALI). Methods:..
... local vendors of Global Acute Lung Injury Market, some of them are GSK, Altor BioScience Corp, Faron Pharmaceuticals Oy, Altor BioScience Corp, APEPTICO,
TY - JOUR. T1 - New insights into acute lung injury. AU - Black, Stephen Matthew. PY - 2010/5/1. Y1 - 2010/5/1. UR - http://www.scopus.com/inward/record.url?scp=77951021969&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=77951021969&partnerID=8YFLogxK. U2 - 10.1016/j.vph.2010.02.002. DO - 10.1016/j.vph.2010.02.002. M3 - Editorial. C2 - 20188857. AN - SCOPUS:77951021969. VL - 52. SP - 171. EP - 174. JO - Vascular Pharmacology. JF - Vascular Pharmacology. SN - 1537-1891. IS - 5-6. ER - ...
Human CD34+ Progenitor Cells Freshly Isolated from Umbilical Cord Blood Attenuate Inflammatory Lung Injury following Lipopolysaccharide Challenge
Sigma-Aldrich offers abstracts and full-text articles by [Hongping Xia, Xiaomeng Ren, Craig S Bolte, Vladimir Ustiyan, Yufang Zhang, Tushar A Shah, Tanya V Kalin, Jeffrey A Whitsett, Vladimir V Kalinichenko].
The US has witnessed a spate of patients presenting with acute lung injury associated with e-cigarettes or vaping product use. A new study published in the journal JAMA Internal Medicine shows the pattern of the outbreak in California where recreational cannabis use is legal and which has among the maximum cases of the strange illness ...
Tassiopoulos AK, Carlin RE, Gao Y, Pedoto A, Finck CM, Landas SK, Tice DG, Marx W, Hakim TS, McGraw DJ. Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities. J Vascular Surg 26:647, 1997 ...
CDC officials found vitamin E acetate, an oil derived from the vitamin, in all 29 samples of lung fluid collected from patients who had fallen ill or died from lung injuries.. This story is from The Seattle Times. Read the rest of this News story at https://www.seattletimes.com/nation-world/nation/potential-culprit-found-in-vaping-related-lung-injuries-and-deaths/?utm_source=RSS&utm_medium=Referral&utm_campaign=RSS_seattle-news.. ...
Figure 3: The anti-inflammatory mechanism of omentin. Omentin activates AMPK, which further blocks E-selection and reduces endothelial inflammation. AMPK also activates eNOS, which has vasodilation effect and blocks JNK signaling. JNK activates inflammation through TNFα mediated COX2 effect. Moreover, omentin inhibits NF-κB signaling pathway and thus inhibits inflammation. Under obese state, the production of omentin is lower which is associated with worse proinflammation and possible lung injury ...
A newly recognized step in development of sepsis-induced lung injury looks like a promising therapeutic target, researchers suggested. Also this week: the need for light in utero.
Centers for Disease Control and Prevention says THC Products May Play a Role in Outbreak of Lung Injury Associated with E-cigarette Use, or Vaping | site |
The investigations of the multi-state outbreak of lung injuries related to vape has led to the discovery that they have often involved THC products, according to the CDC (Centers for Disease Control and Prevention), FDA (Food and Drug Administration) state and local health departments and other clinical/public health p
Sara M. Camp, Ermelinda Ceco, Carrie L. Evenoski, Sergei M. Danilov, Tong Zhou, Eddie T. Chiang, Liliana Moreno-Vinasco, Brandon Mapes, Jieling Zhao, Gamze Gursoy, Mary E. Brown, Djanybek M. Adyshev, Shahid S. Siddiqui, Hector Quijada, Saad Sammani, Eleftheria Letsiou, Laleh Saadat, Mohammed Yousef, Ting Wang, Jie Liang, and Joe G. N. Garcia. "Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NF?B Signaling and Inflammatory Lung Injury", Scientific Reports, 2015, 14(5), 13135 ...
Phospholipase, Inhibition, mRNA, Role, Treatment, Concentration, Immunofluorescence, Acute Lung Injury, Administration, Compliance, Edema, Gene, Inflammation, Injury, Lung, Lung Injury, Mice, Myeloperoxidase, Neutrophil, Pulmonary Injury
Injury, Lung, Lung Injury, Permeability, Endothelial Cell, Cell, Human, Acute Lung Injury, Anp, Inflammation, Kinase, Lung Inflammation, Inhibition, Electrical Resistance, Gtpase, Phosphorylation, Sepsis, Thrombin, Role, Treatment
Study points to a phosphorylation pathway that may contribute to the development of lung injury and fibrosis A study by researchers at the University of California, San Diego School of Medicine may lead to a way to prevent the progression, or induce the regression, of lung injury that results from use of the anti-cancer chemotherapy…