Pneumonia is the leading infectious cause of death in developed countries. Among the vast diversity of respiratory pathogens, fungi account for only a small portion of community-acquired and nosocomial pneumonias.
The incidence of invasive fungal infection is increasing worldwide, and pulmonary infections in particular have become a major clinical challenge and threat to patients at risk. Most fungal pathogens causing pulmonary infections in humans are ubiquitous in the environment and inhalation is the most common route of acquisition, although pulmonary involvement in disseminated infections originating from other foci may occur. This chapter provides an overview on current diagnostic approaches and therapeutic strategies for the most common pulmonary fungal infections. Effective host defence against pulmonary fungal infections strongly depends on an efficient interaction between different parts of the innate and acquired immunity. Therefore, patients with innate and/or acquired/drug-induced impairment of the immune system and critically ill patients are at highest risk. Furthermore, genetic variations and polymorphisms of genes encoding for different constituents of the immune system seem to increase ...
Author Summary Systemic fungal infections have emerged as a public health problem, especially for patients with suppressed immunity. At present, there are no vaccines against fungi, partly because it is hard to elicit strong immunity in immune suppressed patients. We have found however that residual elements of T cell immunity can be harnessed by vaccination even in immune suppressed hosts. We show here that immune suppressed mice lacking T helper cells can still be vaccinated successfully against lethal fungal pneumonia. A population of T cytotoxic IL-17-producing cells (Tc17 cells) is instrumental and indispensible in vaccine protection. We describe here mechanisms that explain how these cells are induced to mature in Tc17 cells, persist for long periods in the body providing
Pneumocystis carinii fungal pneumonia with fungi filling the alveolar spaces of a human lung section. The pathogens are stained brown by the immunoperoxidase method. LM X26 - Stock Image C008/6040
http://healthypets.mercola.com/sites/healthypets/archive/2013/01/28/pneumonia-types.aspx Dr. Karen Becker, a proactive and integrative wellness veterinarian, talks about two other types of pneumonia: bacterial and fungal pneumonia....
To our knowledge, the present study was the first to compare the diagnostic value of measuring BDG levels in TA, BAL, and serum for the detection of suspected CP in immunocompromised and critically ill patients. The major findings were that measuring BDG levels in respiratory specimens, including both TA and BAL fluid, exerted good diagnostic value for the detection of suspected CP, particularly in the absence of concurrent candidemia. In contrast, measuring the serum BDG level had no diagnostic value for this detection.. There are limited data regarding measuring BAL BDG levels to diagnose fungal pneumonia. The performance of BAL BDG at different cutoff value to diagnose non-Candida fungal pneumonia varied widely, in terms of sensitivity (53-90%) and specificity (26-88%) in different patient populations [25-28]. Among these, the largest study (268 BALs) reported by Prattes et al., who compared BAL galactomannan and BDG to diagnose proven/probable invasive pulmonary aspergillosis. They concluded ...
In this study, we employed LSFM for the first time to simultaneously investigate the anatomical distribution of the pathogenic fungus A. fumigatus and define the immune cell populations in murine models of pulmonary fungal infection. LSFM proved superior to current gold standard techniques in providing quantitative data in the context of spatial anatomical information from analyses of large volumes of mouse lung tissue. Previously, the fungal burden (i.e., the degree of fungal growth) had been measured by CFU or by qPCR. Along these lines, quantification of the number of immune cells in whole lungs and phenotypic characterization of those cells were performed with flow cytometry. However, those methods require homogenization of the lungs and thus result in destruction of the anatomical context of lung tissues. In contrast, LSFM enabled us to quantify fungal burden in the intact tissue environment and to visualize differentiated A. fumigatus phenotypes and structures of hyphal growth invading the ...
I still have infiltrates in my lungs. Some areas were better and some were worse. Apparently fungal pneumonia can be asymptomatic, so having clear sounding lungs doesnt necessarily mean anything. Ill continue on the IV infusions twice a day of Vorconazole and hopefully things will clear up. I got my familiar biopsy tech yesterday who does nothing but biopsies all day long and is quite good at them and also good to assist me in breathing. Deep breath in and let it out during aspiration -- somehow it helps. This time it actually came out as more of a breath and less of a scream, and he was able to get the necessary marrow in one pull. For those in the know, you know thats really cool. :-) By the time I saw my doctor my drugs had kicked in pretty heavy, so I am not the best source of information regarding the appointment. Hes not closing the door on me yet, though he will not yet agree to second transplant. We need to see what the biopsy looks like (results next week) and go from there. He ...
I still have infiltrates in my lungs. Some areas were better and some were worse. Apparently fungal pneumonia can be asymptomatic, so having clear sounding lungs doesnt necessarily mean anything. Ill continue on the IV infusions twice a day of Vorconazole and hopefully things will clear up. I got my familiar biopsy tech yesterday who does nothing but biopsies all day long and is quite good at them and also good to assist me in breathing. Deep breath in and let it out during aspiration -- somehow it helps. This time it actually came out as more of a breath and less of a scream, and he was able to get the necessary marrow in one pull. For those in the know, you know thats really cool. :-) By the time I saw my doctor my drugs had kicked in pretty heavy, so I am not the best source of information regarding the appointment. Hes not closing the door on me yet, though he will not yet agree to second transplant. We need to see what the biopsy looks like (results next week) and go from there. He ...
Mucormycosis is an opportunistic pathogen in the zygomycetes class. Pulmonary mucormycosis results by inhalation of sporangiospores into the bronchioles and alveoli. Clinical and radiological findings of the disease are nonspecific. Infarction or necrosis can lead to pneumonia and the infection can spread to neighbouring structures such as the mediastinum and heart, or hematogenously spread to other organs. The radiological manifestations of pulmonary mucormycosis are mostly non-specific. Patch-like consolidations and cavitary lesions can be seen on chest graphy. Hemoptysis is a fatal complication. We report a case of pulmonary mucormycosis in an adolescent diabetic patient as such cases have been rarely reported in literature.. A 16-year-old girl presented with complaints of fever, chills, fatigue, cough, and shortness of breath. Patient was admitted to the hospital with the diagnosis of diabetic ketoacidosis and pneumonia. The patient was diagnosed with Type 1 DM for 5 years. There was a ...
A number of methods are used to diagnose fungal pneumonia. Ones that are commonly used in clinical practice include radiographic imaging (chest X-rays and computed tomography (CT) scans), blood tests, and cultures taken from fluid from the lungs (broncho-alveolar lavage (BAL) fluid). Other new methods may improve the diagnosis of fungal pneumonias. These methods include tests that can detect DNA from the fungal germ in blood and BAL fluid of some patients with these infections ...
Objective: To evaluate cases of chronic pulmonary histoplasmosis diagnosed in recent years at the Complexo Hospitalar Santa Casa in Porto Alegre, in the state of Rio Grande do Sul, Brazil. Methods: Cases diagnosed at the Santa Casa Hospital Complex within the last 25 years were reviewed. Four cases in which the diagnosis was made through histopathological analysis or culture and confirmed by with serologic testing are described. Cases from the Brazilian literature are also discussed. Results: The principal clinical manifestations were cough, dyspnea, fever, anorexia and weight loss. Among the radiological findings were emphysema, cystic cavities, bronchiectasis and pleural thickening. All patients had an epidemiological history of contact with chicken feces. One of the patients presented Aspergillus fumigatus colonization of cavities. Conclusion: Chronic pulmonary histoplasmosis must be considered in patients with chronic obstructive pulmonary disease presenting cavitary lesions of the lung, ...
It appears to be an emerging infection according to this review. Think of it in cases of recurrent or non resolving pneumonias especially in the immunocompromised. ...
Bacteria, viruses, or fungi may cause pneumonia, or inflammation of the lungs. Read about pneumonia symptoms, treatment, and vaccines. Viral, bacterial, and fungal pneumonia are contagious.
Parasitism is a kind of symbiosis, a close and persistent long-term biological interaction between a parasite and its host. Unlike commensalism and mutualism, the parasitic relationship harms the host, either feeding on it or, as in the case of intestinal parasites, consuming some of its food.. acquired trait: A phenotypic characteristic, acquired during growth and development, that is not genetically based and therefore cannot be passed on to the next generation (for example, the large.. Bacteria, viruses, or fungi may cause pneumonia, or inflammation of the lungs. Read about pneumonia symptoms, treatment, and vaccines. Viral, bacterial, and fungal pneumonia are contagious. Sometimes symptoms are not severe at first leading to. Past Conference Report. Antibiotics 2018. The 6 th Edition of International Conference on Antibiotics, Antimicrobials & Resistance was held on October 11-12, 2018 in Edinburgh, Scotland with the presence of professional researchers, scientists involved in the development ...
TY - JOUR. T1 - Pulmonary Histoplasmosis Syndromes. T2 - Recognition, Diagnosis, and Management. AU - Wheat, L. Joseph. AU - Conces, Dewey. AU - Allen, Stephen D.. AU - Blue-Hnidy, Debotah. AU - Loyd, James. PY - 2004/4/1. Y1 - 2004/4/1. N2 - Pulmonary manifestations are the hallmark of histoplasmosis. Clinical syndromes range from asymptomatic infection to diffuse alveolar disease causing respiratory difficulty and even death. Serologic tests for antibodies and antigen detection are especially helpful in the diagnosis of histoplasmosis but are frequently overlooked. Detection of Histoplasma capsulatum antigen in bronchoalveolar lavage fluid may be particularly helpful in patients with acute pulmonary histoplasmosis or disseminated disease with pulmonary involvement. Topics of special importance for pulmonary disease specialists include the approach to the exclusion of histoplasmosis in the evaluation of patients with suspected sarcoidosis, differentiation of pulmonary histoplasmosis and ...
TY - JOUR. T1 - Pulmonary coccidioidomycosis. AU - Thompson, George Richard. PY - 2011. Y1 - 2011. N2 - Coccidioidomycosis refers to the spectrum of disease caused by the dimorphic fungi Coccidioides immitis and Coccidioides posadasii. Clinical manifestations vary depending upon both the extent of infection and the immune status of the host. Coccidioidomycosis has been reported to involve almost all organ systems; however, pulmonary disease is the most common clinical manifestation. The incidence of coccidioidomycosis continues to rise, and primary coccidioidal pneumonia accounts for 17 to 29% of all cases of community-acquired pneumonia in endemic regions. The majority of patients with coccidioidomycosis resolve their initial infection without sequelae; however, several patients develop complications of disease ranging in severity from complicated pulmonary coccidioidomycosis to widely disseminated disease with immediately life-threatening manifestations. This review focuses on complications of ...
A previous study explored factors discriminating colonization and true infection among non-transplant, non-neutropenic patients with repeated Aspergillus spp. isolation from lower respiratory samples. The present study explored the evolution of patients with Aspergillus colonization in that study to determine the percentage of cases progressing to aspergillosis and time to development. Clinical records were retrospectively reviewed (for each patient from his end date in the past study) and data from all respiratory processes suffered by patients up to April 2015 were recorded. Comparisons of variables were performed between colonized patients that developed aspergillosis and those that did not. A Kaplan-Meier curve was used to describe time to development of aspergillosis in chronic obstructive pulmonary disease (COPD) patients for II-IV stages of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Sixty seven colonized patients were followed, 12 of them (17.9%) developed
Introduction. Invasive pulmonary aspergillosis (IPA) remains a major clinical issue in Acute Leukemia (AL) patients (pts) and can affect the outcome of hematological treatment. Acute Myeloid Leukemia (AML) is considered the most frequent hematological condition predisposing to IPA; however, the introduction of posaconazole prophylaxis has significantly reduced IPA during AML induction. On the other hand, incidence of IPA among Acute Lymphoblastic Leukemia (ALL) pts seems to be increasing. In order to confirm these epidemiological data and to analyze the impact of IPA on the outcome of AL, we analyzed all AML and ALL pts consecutively admitted to our Institution during a 5-year period of observation. Patients and Methods. From Jul-11 to Jun-16, all consecutive AML and ALL pts admitted to our Institution and treated with intensive chemotherapy were analyzed. IPA was diagnosed according to EORTC/MSG criteria and categorized as possible (poss) and probable/proven (p/p). Anti-mold prophylaxis ...
Chest radiographs (CXR) are an important diagnostic tool for the detection of invasive pulmonary aspergillosis (IPA) in critically ill patients, but their diagnostic value is limited by a poor sensitivity. By using advanced image processing, the aim of this study was to increase the value of chest radiographs in the diagnostic work up of neutropenic patients who are suspected of IPA.The frontal CXRs of 105 suspected cases of IPA were collected from four institutions. Radiographs could contain single or multiple sites of infection. CT was used as reference standard. Five radiologists and two residents participated in an observer study for the detection of IPA on CXRs with and without bone suppressed images (ClearRead BSI 3.2; Riverain Technologies). The evaluation was performed separately for the right and left lung, resulting in 78 diseased cases (or lungs) and 132 normal cases (or lungs). For each image, observers scored the likelihood of focal infectious lesions being present on a continuous ...
Diagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients (pts) with hematological malignancies. The clinical significance of te
Diagnosis Code B38.1 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Blastomycosis is a common zoonotic fungal infection in endemic areas, like border of the Great Lakes, St. Lawrence River, the Mississippi River and Ohio River. Human infection is common in those areas, and occurs when airborne conidia are inhaled from the soil. If the contacted persons immunity fights against the fungus, it can be contained, but if not, the dimorphic fungus develops into the yeast form and the yeast forms migrate to other sites through blood and lymphatic system. Lungs are the most common initially affected organ ...
Principal Investigator:NASU Masaru,橋本 敦郎, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Respiratory organ internal medicine
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Backgroud: Critically ill COPD patients who require ICU admission are at particular risk of invasive pulmonary aspergillosis (IPA).. Objective: To investigate the value of galactomannan (GM) in BALF for rapid diagnosis and prognosis of IPA in critically ill COPD patients.. Design: We investigated the clinical data of patients with severe COPD in RICU of Beijing Chaoyang Hospital from February 2009 to December 2009 prospectively. Patients were divided to proven, probable, possible, colonization and non-IPA group. Serum GM and BALF GM were done at the first day of RICU admission.. Results: 50 patients were recruited in the study,and 34 patients had BALF samples which were classified as probable IPA, possible IPA (n=6), 2 colonization (n=2) and non-IPA group (n=17); According to the ROC curve, when chose 0.795 as the cut-off of BALF GM test, the sensitivity, specificity, positive and negative predictive value for probable IPA were 88.9%, 95.1%, 100% and 93.7%, respectively;All of the patients of ...
The overall pass rate for the written paper was 75%. The college examiners have made the following comments about this written paper: Twelve of the thirty questions had an overall pass rate of less than 50%. Topics covered by questions with a pass rate of less than 30% related to invasive pulmonary aspergillosis, SSEPs, management of confusion and fever in a young woman post-partum and management of respiratory failure in a patient with an anastamotic leak post-oesophagectomy
Fungal pneumonia refers to a form of pneumonia in which the lungs become inflammed due to a deep fungal infection, known as a mycotic infection.
Author:Gaurishanker P Shrimali, Jaymin K Bhatt, Rakesh Rajat, Rohit V Parmar, Sunil Nayak, D Chandralekha. Keywords:Chronic Respiratory Disease. Pulmonary Aspergillosis, Immunosuppressant, fungus ball, Aspergilloma. Type:Original Article. Full PDF Abstract ...
A skin lesion of blastomycosis is a symptom of an infection with the fungus Blastomyces dermatitidis. The skin becomes infected as the fungus spreads throughout the body. Another form of blastomycosis is only on the skin and usually gets better on its own with time. This article deals with the more widespread form of the infection.
Blastomycosis may present with fever, pain in the chest and production of sputum. Blastomycosis is caused by Blastomyces dermatitidis.
AbstractBACKGROUNDThe development of pulmonary infiltrates is a frequent life threatening complication in immunocompromised patients, requiring early diagnosis and specific treatment. In the present study non-invasive and bronchoscopic diagnostic techniques were applied in patients with different no
Chronic pulmonary aspergillosis (CPA) is an uncommon and problematic pulmonary disease, complicating many other respiratory disorders, thought to affect ∼240 000 people in Europe. The most common form of CPA is chronic cavitary pulmonary aspergillosis (CCPA), which untreated may progress to chronic fibrosing pulmonary aspergillosis. Less common manifestations include: Aspergillus nodule and single aspergilloma. All these entities are found in non-immunocompromised patients with prior or current lung disease. Subacute invasive pulmonary aspergillosis (formerly called chronic necrotising pulmonary aspergillosis) is a more rapidly progressive infection (,3 months) usually found in moderately immunocompromised patients, which should be managed as invasive aspergillosis. Few clinical guidelines have been previously proposed for either diagnosis or management of CPA. A group of experts convened to develop clinical, radiological and microbiological guidelines. The diagnosis of CPA requires a ...
BACKGROUND AND METHODS: Symptomatic pulmonary aspergillosis has rarely been reported in patients with the acquired immunodeficiency syndrome (AIDS). We describe the predisposing factors, the clinical and radiologic features, and the therapeutic outcomes in 13 patients with pulmonary aspergillosis, all of whom had human immunodeficiency virus (HIV) infection and 12 of whom had AIDS.!,br,!!,br,!RESULTS: Pulmonary aspergillosis was detected a median of 25 months after the diagnosis of AIDS, usually following corticosteroid use, neutropenia, pneumonia due to other pathogens, marijuana smoking, or the use of broad-spectrum antibiotics. Two major patterns of disease were observed: invasive aspergillosis (in 10 patients) and obstructing bronchial aspergillosis (in 3). Cough and fever, the most common symptoms, tended to be insidious in onset in patients with invasive disease (median duration, 1.3 months before diagnosis). Breathlessness, cough, and chest pain predominated in the three patients with ...
The invasive fungal infection (IFI) is the most common cause of mortality related to autologous stem cell transplant. Taking into account that Saprophytic Aspergillus is usually acquired by inhalation, to protect the bronchial tree just before the tissue invasion is quite attractive. In haematologic patients, as well as those ones subjected to an Allogeneic haematopoietic progenitor cell transplant, there is another group of patients at high risk of Invasive Pulmonary Aspergillosis (IPA). These are those patients with acute myeloid leucemia (AML), submitted to induction, intensification or consolidation polychemotherapy. The IPA incidence rate in these patients, whenever during their evolution, reaches 18-20%, with usual treatments. Furthermore, unlike allogeneic haematopoietic progenitor cell transplant patients, neutropenia was the only IPA risk factor. Nowadays, pharmacologic prophylaxis against IPA, in patients with allogeneic haematopoietic progenitor cell transplant and patients affected ...
The pharmacokinetics, efficacy, and safety of intravenous (iv) itraconazole (2 days at 400 mg/day, 12 days at 200 mg/day), followed by 12 weeks of oral capsules (400 mg/day) were studied in 31 immunocompromised patients with pulmonary invasive aspergillosis. All patients received iv itraconazole (median duration, 14 days), and 26 then received oral itraconazole (median duration, 78.5 days). After receiving iv itraconazole, concentrations increased rapidly, with trough plasma levels ⩾250 ng/mL in 91% of patients and in all patients by day 7. Concentrations ⩾500 ng/mL were observed in 64% of patients by day 2. Mean trough concentrations after 2 and 14 days were 670 and 850 ng/mL, respectively. Therapeutic levels were maintained after switching to oral capsules. A complete or partial response was seen at the last on-treatment assessment in 15 (48%) of 31 patients, with 6 (19%) showing stable disease. Itraconazole was well tolerated, with no unexpected effects. Overall iv/oral itraconazole was ...
... Expert Rev Respir Med. 2020 Apr 05;: Authors: Sehgal IS, Dhooria S, Muthu V, Prasad KT, Agarwal R Abstract Introduction: Chronic pulmonary aspergillosis (CPA) is a chronic infection of the lung parenchyma caused by Aspergillus fumigatus complicating structural lung diseases. Of the different ...
A 51-year-old man, with a history of severe COPD and bilateral pneumothorax, who was under treatment for pulmonary tuberculosis due to mycobacterium avium, was admitted due to high-grade fever, weight loss, cough, and production of purulent sputum, for almost one month without any special improvement despite adequate antibiotics treatment in outpatient setting. A CT scan revealed multiple consolidations, fibrosis, scaring, and cavitary lesions in both upper lobes with newly shadows which were fungus balls inside them. Aspergillus flavius was isolated in three sputum samples, a diagnosis of chronic cavitary pulmonary aspergillosis was made, and treatment with intravenous amphotericin B was started. An initially clinical improvement was noted, and a first episode of minor hemoptysis was treated with conservative measures. Unfortunately a second major episode of hemoptysis occurred and he died almost immediately. Aspergilloma is defined as the presence of a fungus ball inside a preexisting pulmonary
We investigated a cluster of blastomycosis in 8 humans and 4 dogs in a rural North Carolina community. Delayed diagnosis, difficulty isolating Blastomyces dermatitidis in nature, and lack of a sensitive and specific test to assess exposure make outbreaks of this disease difficult to study.
Strong clinical and experimental evidence links qualitative and quantitative neutrophil deficiencies to fatal infections caused by A. fumigatus. Yet the role of the neutrophil in mediating the protection observed in normal hosts remains largely unknown. Recent studies indicate neutrophils from CXCR2-/- mice are unable to migrate toward chemokine gradients of KC and MIP-2, rendering these animals susceptible to fatal aspergillosis. Mice with a mutation in the gene encoding for the gp91phox component of the NADPH oxidase lack the ability to generate the reactive oxygen metabolites used by phagocytes in killing microbial pathogens, and these mice are also susceptible to invasive pulmonary aspergillosis. In this investigation of the innate response to A. fumigatus, CXCR2-/- and gp91-/- mice were used to mimic the qualitative and quantitative neutrophil defects that are known to predispose to invasive pulmonary aspergillosis, the most lethal form of Aspergillus diseases. By comparing the nature of ...
TY - JOUR. T1 - Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responses. AU - Feldmesser, Marta. AU - Mednick, Aron. AU - Casadevall, Arturo. PY - 2002. Y1 - 2002. N2 - Cryptococcus neoformans, an encapsulated yeast, is a common cause of life-threatening meningoencephalitis in immunosuppressed patients. We previously observed that administration of a monoclonal antibody (MAb) to the capsular polysaccharide to mice with pulmonary infection prolonged survival and enhanced granulomatous inflammation without reducing lung CFU. To understand the mechanism of MAb action, we studied leukocyte recruitment and cytokine profiles in lungs of A/JCr mice. B lymphocytes were the predominant cell type in lung infiltrates, comprising 15 to 30% of the leukocytes. Despite alterations in histological appearance, fluorescence-activated cell sorter analysis revealed no significant difference in total numbers of lung ...
Invasive pulmonary aspergillosis (IPA) optimal duration of antifungal treatment is not known. In a joint effort, four international scientific societies/groups performed a survey to capture current practices in European haematology centres regarding management of IPA. We conducted a cross-sectional internet-based questionnaire survey in 2017 to assess practices in sixteen European countries concerning IPA management in haematology patients including tools to evaluate treatment response, duration and discontinuation. The following four groups/societies were involved in the project: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG), Infectious Diseases Working Party-European Society for Blood and Bone Marrow Transplantation (IDWP-EBMT), European Organisation for Research and Treatment-Infectious Disease group (EORTC-IDG) and Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM). A total of 112 physicians from 14/16 countries ...
A case of disseminated bilateral pulmonary adiaspiromycosis is reported in a two year old Finnish girl. She recovered from this rare infection after treatment with amphotericin B. She is the first human case of adiaspiromycosis in Scandinavia and she is the youngest child with this disease reported so far. Electron microscopy showed that the three layers of the spore wall were not typical; rather, there seemed to be a gradual transition between the main wall zones, which may be split into an indefinite number of thin layers. Varying numbers and thicknesses were seen with different staining methods, and in different spores. Diagnosis relies on recognition of the fungus in a pulmonary biopsy specimen, because there are no reliable serological tests and culture of the fungus is time consuming and not always successful. It was thought that this patient had become infected as a result of contact with soil dust containing the spores in the yard surrounding her home, and as a result of her mothers ...
Mucormycosis is an infection caused by filamentous fungi that presents in different forms: rhinocerebral, pulmonary, renal, cutaneous, and gastrointestinal. The species Rhizopus oryzae, responsible for 70% of cases, is the most frequently isolated organism.1 Risk factors for developing mucormycosis include blood diseases, diabetes mellitus with poor metabolic control, solid organ or hematopoietic transplantation, neutropenia, injury, iron overload, and severe burns. It is unclear whether the chronic use of corticosteroids predisposes patients to developing mucormycosis. In recent years, we have witnessed an increase in the incidence of this entity due to population aging, which goes hand in hand with an increase in the above-mentioned risk factors.2,3. We report the case of a 29-year-old woman, smoker of 10 pack-years, with recent onset of diabetes mellitus type 1 (ketoacidosis the week before presentation of this clinical episode). She consulted due to a few hours history of dyspnea, fever ...
Granuloma - A granuloma is a little breadth of deepening in tissue due to injury, such as from an infection. Granulomas a lot of frequently appear in the lungs but can action in added locations of the physique as fit. Typically, a granuloma encompasses alone a tiny allotment of the tissue. For the a lot of part, a being with a granuloma does not acquaintance any signs or symptoms. Granulomas can be acquired by a array of biologic, actinic and concrete irritants of tissue. The a lot of accepted could could could cause of granuloma is histoplasmosis, a fungal infection that primarily affects the lungs. A lot of humans with pulmonary histoplasmosis never doubtable that they accept the disease ...
Dr. Mark Wurth is a pediatric pulmonologist at the UK Kentucky Clinic Pediatric Specialty Clinic. He is a native of Henderson, Ky. and completed his undergraduate work, a PhD and medical school at UK.. Dr. Wurths clinical interests include severe asthma and phenotype driven therapeutics for asthma management, and he is currently section head of pediatric allergy and immunology. His research interests include understanding the immune response that drives mold allergy in severe asthma and allergic bronchopulmonary mycosis. In addition to his clinical work and research, Dr. Wurth teaches first year medical students about primary immunodeficiency diseases.. ...
폐 효모균증 치료의 목적은 폐렴의 증상과 징후의 조절, 파종의 예방, 그리고 재발의 방지 등이다. 일반적으로 면역기능과 증상의 정도에 따라 기간과 용량에 차이가 있으며, 가장 흔하게 사용되는 항진균제는 fluconazole를 비롯하여 심각한 증상의 경우에는 amphotericin B, flucytocin 등을 사용하며, itraconazole을 대체제로 사용할 수 있다[2,14,15]. 그러나 면역기능이 정상인 환자에서는 파종성의 증거가 없거나 전신적 증상이 없는 경우는 항진균제 치료 없이도 호전될 수 있음을 보여준 경우도 있으나 [6] , 경증 이상의 경우는 fluconazole을 하루에 400 mg, 3-6개월 또는 12개월까지 사용함을 추천하고 있다 [15] . 국내의 증례에서는 고립성 폐결절로 발현된 면역기능이 정상인 환자에서 초기 내원 시 조직검사를 거부한 환자에서 3개월 뒤 2배 이상 커진 증례가 있었다 [12] . 본 ...
Synonyms for blastomycosis in Free Thesaurus. Antonyms for blastomycosis. 3 words related to blastomycosis: chromoblastomycosis, fungal infection, mycosis. What are synonyms for blastomycosis?
CONCLUSIONS: Fungal infection should always be considered in patients with sinusitis and previous root canal theraphy. Misdiagnosis can lead to severe complications. Surgical removal seems to be effective and resolutive. KEY WORDS: Endoscopic surgery, Fungus Ball, Maxillary sinusitiss. PMID: 32876052 [PubMed - in process]...
Information on the disease, the testing procedures and the research being undertaken at the University Hospital of South Manchester, which provides long term care for patients with chronic pulmonary aspergillosis. ...