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Losartan Potassium : Losartan potassium is an angiotensin II receptor antagonist. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors.
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To assess the effect of angiotensin II type 1 (AT1) receptor antagonist losartan on myocardium connexin43 (Cx43) gap junction (GJ) expression in spontaneously hypertensive rats (SHRs) and investigate possible mechanisms. Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto (WKY) rats...
First, I have observed in my referral patients that reduction of albuminuria or proteinuria with angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor antagonists, such as losartan, happens only at the expense of reduction of glomerular filtration rate (GFR). It is quite evident in Zandbergen and colleagues article that the losartan group had a mean reduction of almost 10% (9.7%) in creatinine clearance over a 10-week period. The decline in GFR was reversible, as shown during the washout period. Therefore, one can argue that reduction of albuminuria in the losartan group was due to reduction of GFR. One can also argue that if therapy with the drug is continued for longer than 10 weeks, more reduction of proteinuria can be expected but in parallel with reduction of GFR ...
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The renin-angiotensin system plays a central role in the pathophysiology of HF. ACE inhibitors improve symptoms and reduce mortality in HF, and it is believed that these benefits can be attributed to decreased angiotensin II formation as well as to bradykinin potentiation and resultant vasodilatory and endothelial protective actions. The Evaluation of Losartan in the Elderly (ELITE) trial is a long-term, moderately sized trial. In this trial, a trend existed toward a reduction in death or hospitalization (or both) for patients with HF receiving losartan. Patients receiving losartan also had fewer adverse effects that required drug discontinuation; primarily, these patients had a lower incidence of cough. These data and another preliminary report of improved survival with losartan compared with placebo suggest a role for angiotensin-receptor blockers in HF and bring into question the mechanism by which ACE inhibitors effect clinical improvements (1). Alternate pathways of angiotensin II formation ...
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Losartan is an angiotensin II receptor antagonist. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losartan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain...
Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker). Losartan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease. Losartan is also used to slow long-term...
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