Authors: Raymond Noordam, Anton JM de Craen, Pardis Pedram, Andrea B Maier, Simon P Mooijaart, Johannes van Pelt, Edith J Feskens, Martinette T Streppel, P Eline Slagboom, GJ Westendorp, Marian Beekman, Diana van Heemst
Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally long lives. Using data from the Long Life Family Study (LLFS), we sought to replicate these findings and extend them to include a larger number of disease‐specific risk alleles. To accomplish this goal, we built a genetic risk score for each of four age‐related disease groups: Alzheimers disease, cardiovascular disease and stroke, type 2 diabetes, and various cancers and compared the distribution of these scores between older participants of the LLFS, their offspring and their spouses. The analyses showed no significant differences in distribution of the genetic risk scores for cardiovascular disease and stroke, type 2 diabetes, ...
Abstract The Chinese Longitudinal Healthy Longevity Study (CLHLS) is a large-scale population-based study on health status and quality of life of the elderly in 23 provinces (out of 31 provinces) of China since 1998 with 8 waves so far. The study covers approximately 85% of the total population of China and was conducted to shed light on the determinants of human healthy longevity. The CLHLS tried to interview all consenting centenarians in the sampled counties and cities. For each centenarian interviewee, compatible nearby un-related elderly and younger participants were interviewed, including about one nonagenarian aged 90-99, one octogenarian aged 80-89, 1.5 young-old adult aged 65-79 and 0.7 middle-aged adult aged 40-64. Detailed longitudinal data on physical and mental health, cognitive function, social participation, etc. at old ages were collected from a total of 96,805 face-to-face interviews with 16,557 centenarians, 23,081 nonagenarians, 25,842 octogenarians, 19,650 younger elders aged ...
A similar result was observed with ROS formation. When AUs/pixel were used to quantify ROS generation, a significant increase from 45 ± 6 to 88 ± 4 (P , 0.001) was observed in worms treated with high glucose for 15 days (Fig. 6B). FCCP and myxothiazol reduced ROS formation by 36% in standard and up to 62% in high glucose cultured C. elegans (Fig. 6B). Thus, overcoming high glucose-induced mitochondrial dysfunction reduces MG-H1 and ROS formation.. Treatment with either FCCP or myxothiazol enhanced life span under both conditions (Table 1). FCCP increased mean life span from 18.5 ± 0.4 to 21.7 ± 1.7 days (P , 0.05) and maximum life span from 25.9 ± 0.4 to 31.5 ± 0.5 days (P , 0.01), whereas myxothiazol increased mean life span from 18.5 ± 0.4 to 21.1 ± 1.1 days (P , 0.01) and maximum life span from 25.9 ± 0.4 to 31.0 ± 1.7 days (P , 0.01) under standard glucose conditions (Table 1). Under high glucose conditions, FCCP increased mean life span from 16.5 ± 0.6 to 19.5 ± 0.9 days (P , ...
Human Longevity, Inc. was formed to revolutionize medicine and prolong healthy life. Human Longevity, Inc. is constructing a robust sequencing operation to compile the most comprehensive and complete human genotype, microbiome, metabolome, proteome, and phenotype database available. As part of this process HLI is building one of the largest human genome sequencing centers in the world. While Human Longevity, Inc. is continuing to grow, we are looking for people who share our common goal and passion of changing healthcare and extending the healthy human lifespan.. Job Description Human Longevity, Inc. is looking for a Research Scientist to work as a member of the In Vitro Team. This Research Scientist plays a key role in the development, optimization and implementation of new methods and processes for the analysis of human genetic diversity. This position will work closely with bioinformatics and machine learning teams.. Tasks and Responsibilities ...
Previously, the word healthspan has been used in many scientific contexts, but the definition has been ambiguous at best. Therefore, in this study, we focused on providing a conceptual framework of healthspan that can be easily verified in a laboratory setting using C. elegans. The current study makes no claim that the healthspan parameters tested cover all aspects of healthspan, nor does it make any assumptions that antiaging therapies that extend lifespan cannot coincide with an increase in healthspan. Rather, we highlight limitations of aging studies focused solely on lifespan extension.. Here we defined healthspan broadly by testing multiple assays as the animals aged. We tested wild type as our benchmark and then compared data from four long-lived mutants with wild-type health. From these data, we calculated and compared both the chronological number of days an animal is healthy vs. frail and the percent of the physiological lifespan the animal spends in each state (healthspan:gerospan ...
If anyone can send any information on melatonin and its effects on longevity or perhaps where I might find some journal articles on this subject, I would appreciate any help ...
Scientists have identified the markers for longevity in yeast. By modifying the longevity gene in the microorganism, researchers have extended its life ten-fold. This can have a profound influence on human longevity as well.
View update. December 1, 2011 - New FY 10 - 11 Annual Report, Understanding Californias Demographic Shifts, The State and Future of Financial Fraud: Connecting Research and Practice View update. October 4, 2011 - A New Academic Year Begins at the Stanford Center on Longevity, Stanford Center on Longevity and Population Reference Bureau Issue Index of Well-Being in Older Populations, Stanford Arthritis Shoe Hits Shelves View update. August 3, 2011 - The Effects of White Matter in the Brain, Center on Longevity Seed Grant Explores the Mind-Body Linkage of Tai Chi, Health Care Reform - Public Support and Personal Costs View update. June 29. 2011 - SCL Launches New Website, Understanding Californias Demographic Shifts, Stanford Journal of Public Health is Launched View update ,,,. May 12, 2011 - Distinguished Lecture Series: Marc Freedman, Join Stanford Students in On-Line Discussions on Longevity, Pace of Aging will Accelerate - Everywhere View update ,,,. March 3, 2011 - New FY 09 - 10 ...
TY - JOUR. T1 - Testing the oxidative stress hypothesis of aging in primate fibroblasts. T2 - Is there a correlation between species longevity and cellular ROS production?. AU - Csiszar, Anna. AU - Podlutsky, Andrej. AU - Podlutskaya, Natalia. AU - Sonntag, William E.. AU - Merlin, Steven Z.. AU - Philipp, Eva E R. AU - Doyle, Kristian. AU - Davila, Antonio. AU - Recchia, Fabio A.. AU - Ballabh, Praveen. AU - Pinto, John T.. AU - Ungvari, Zoltan. PY - 2012/8. Y1 - 2012/8. N2 - The present study was conducted to test predictions of the oxidative stress theory of aging assessing reactive oxygen species production and oxidative stress resistance in cultured fibroblasts from 13 primate species ranging in body size from 0.25 to 120 kg and in longevity from 20 to 90 years. We assessed both basal and stress-induced reactive oxygen species production in fibroblasts from five great apes (human, chimpanzee, bonobo, gorilla, and orangutan), four Old World monkeys (baboon, rhesus and crested black macaques, ...
TY - JOUR. T1 - Genotype effect on lifespan following vitellogenin knockdown. AU - Ihle, Kate E.. AU - Fondrk, M. Kim. AU - Page, Robert. AU - Amdam, Gro. N1 - Funding Information: We thank Adam Dolezal, Ying Wang, and Nicholas Baker for assistance with the experimental setups and M. Teague OMara for helpful comments on the manuscript. KEI was supported by the Research Council of Norway (216776/F11) and a postdoctoral fellowship from Arizona State University and the Smithsonian Tropical Research Institute.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Honey bee workers display remarkable flexibility in the aging process. This plasticity is closely tied to behavioral maturation. Workers who initiate foraging behavior at earlier ages have shorter lifespans, and much of the variation in total lifespan can be explained by differences in pre-foraging lifespan. Vitellogenin (Vg), a yolk precursor protein, influences worker lifespan both as a regulator of behavioral maturation and through anti-oxidant and ...
A recent study by my research group appearing next month in Aging Cell reveals shortened longevity as a possible complication associated with ovary removal in dogs (1). This work represents the first investigation testing the strength of association between lifetime duration of ovary exposure and exceptional longevity in mammals. To accomplish this, we constructed lifetime medical histories for two cohorts of Rottweiler dogs living in 29 states and Canada: Exceptional Longevity Cohort = a group of exceptionally long-lived dogs that lived at least 13 years; and Usual Longevity Cohort = a comparison group of dogs that lived 8.0 to 10.8 years (average age at death for Rottweilers is 9.4 years). A female survival advantage in humans is well-documented; women are 4 times more likely than men to live to 100. We found that, like women, female Rottweilers were more likely than males to achieve exceptional longevity (Odds Ratio, 95% confidence interval = 2.0, 1.2 - 3.3; p = .006). However, removal of ...
Aging in humans is a well-established primary risk factor for many disabling diseases and conditions, among them diabetes, cardiovascular disease, Alzheimers disease and cancer. In fact, the risk of death from these causes is dramatically accelerated (100-1000 fold) between the ages of 35 and 85 years. For this reason, there is a need for the development of new interventions to improve and maintain health into old age - to improve healthspan.. Several mechanisms have been shown to delay the aging process, resulting in improved healthspan in animal models, including mammals. These include caloric restriction, alteration in GH/IGF1 pathways, as well as use of several drugs such as resveratrol (SIRT1 activator) and rapamycin (mTOR inhibitor). At Einstein, the investigators have been working to discover pathways associated with exceptional longevity. The investigators propose the study of drugs already in common clinical use (and FDA approved) for a possible alternative purpose -healthy aging. ...
The Long Life Family Study (LLFS) is an international study to identify the genetic components of various healthy aging phenotypes. We hypothesized that pedigree-specific rare variants at longevity-associated genes could have a similar functional impact on healthy phenotypes. We performed custom hybridization capture sequencing to identify the functional variants in 464 candidate genes for longevity or the major diseases of aging in 615 pedigrees (4,953 individuals) from the LLFS, using a multiplexed, custom hybridization capture. Variants were analyzed individually or as a group across an entire gene for association to aging phenotypes using family based tests. We found significant associations to three genes and nine single variants. Most notably, we found a novel variant significantly associated with exceptional survival in the 3 UTR OBFC1 in 13 individuals from six pedigrees. OBFC1 (chromosome 10) is involved in telomere maintenance, and falls within a linkage peak recently reported from an
A recent study suggests that female dogs that keep their ovaries through their whole lives are more likely to live longer than those that don’t.The study, “Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs,” says that female dogs, like women, are more likely to achieve “exceptional longevity” than their male counterparts.The researchers collected information on Rottweilers that lived to be 13 or older, which is more than 30 percent above the average life expectancy for that breed. Female dogs in general lived longer, but the researchers found that removal of the ovaries in the first four years of life “erased the female survival advantage.”
Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the healthspan is also extended with delays in cognitive decline and in the onset of age-related disease. The role of hormones homologous to insulin-like growth factor (IGF, an important mediator of GH actions) in the control of aging and lifespan is evolutionarily conserved from worms to mammals with some homologies extending to unicellular yeast. The combination of reduced GH, IGF-I, and insulin signaling likely contributes to extended longevity in GH or GH receptor-deficient organisms. Diminutive body size and reduced fecundity of GH-deficient and GH-resistant mice can be viewed as trade-offs for extended longevity. Mechanisms responsible for delayed aging of GH-related mutants include enhanced stress resistance
Senescent cells are more prevalent in aged human skin compared to young, but evidence that senescent cells are linked to other biomarkers of aging is scarce. We counted cells positive for the tumor suppressor and senescence associated protein p16INK4a in sun-protected upper-inner arm skin biopsies from 178 participants (aged 45-81 years) of the Leiden Longevity Study. Local elastic fiber morphology, facial wrinkles, and perceived facial age were compared to tertiles of p16INK4a counts, while adjusting for chronological age and other potential confounders. The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 ...
Twin studies have shown that longevity in humans is moderately heritable with a genetic component of 25-32%. Experimental model organisms point to the existence of core survival and anti-ageing pathways that have been conserved throughout evolution. It has been shown that mutations in single genes involved in these pathways can either delay or accelerate the ageing process and that many of these genes and pathways are also present in humans. Here, we performed a targeted investigation of selected genes (i) involved in longevity pathways (insulin receptor/insulin-like growth factor-I signaling and energy metabolism, intracellular signaling, apoptosis and stress response) and (ii) in which mutations lead to genetic perturbations in animal models or human diseases. Altogether, we tested 500 nonsynonymous single nucleotide polymorphisms (SNPs) in 343 candidate genes for association with the longevity phenotype in a German sample comprising about 400 centenarians and an equal number of younger ...
Authors: Walter, Ludivine; Baruah, Aiswarya; Chang, Hsin-Wen; Pace, Heather Mae; Lee, Siu Sylvia. Abstract: Recent findings indicate that perturbations of the mitochondrial electron transport chain (METC) can cause extended longevity in evolutionarily diverse organisms. To uncover the molecular basis of how altered METC increases lifespan in C. elegans, we performed an RNAi screen and revealed that three predicted transcription factors are specifically required for the extended longevity of mitochondrial mutants. In particular, we demonstrated that the nuclear homeobox protein CEH-23 uniquely mediates the longevity but not the slow development, reduced brood size, or resistance to oxidative stress associated with mitochondrial mutations. Furthermore, we showed that ceh-23 expression levels are responsive to altered METC, and enforced overexpression of ceh-23 is sufficient to extend lifespan in wild-type background. Our data point to mitochondria-to-nucleus communications to be key for longevity ...
Chronic treatment of female transgenic HER-2/neu mice with metformin slightly decreases food consumption but fails to reduce body weight or temperature, slows down age-related rise in blood glucose and triglycerides level, as well as the age-related switch-off of estrous function, prolongs mean lifespan by 8% (p < 0.05), the mean lifespan of last 10% survivors by 13.1% and maximum lifespan by 1 month. Metformin treatment significantly decreases incidence and size of mammary adenocarcinomas and increases the mean latency of the tumors [16125352]. Chronic treatment of female outbred SHR mice with metformin slightly modified food consumption but decreases the body weight after the age of 20 months, slows down the age-related switch-off of estrous function, increases mean lifespan by 37.8% mean lifespan of the last 10% survivor by 20.8%, and maximum lifespan by 2.8 month (+10.3%). Treatment with metformin fails to influence blood estradiol concentration and spontaneous tumor incidence in female SHR ...
But it helps to be mindful. There are some findings to suggest that being mindful can actually have effects on lifespan. One such study looked at people attending a three-month stay at a meditation retreat and found that after the three months the meditators had on average about 30% more activity of the enzyme telomerase than the controls did, which is related to aging. The findings are very preliminary, but they suggest that the mind does have influence on the body.. You dont have to be a Pollyanna. While a constantly pleasant disposition seems like it would put people at a lower stress level (and therefore make them healthier) the Longevity Study researchers say that thinking positive isnt necessarily healthy. If youre … very optimistic, especially in the face of illness and recovery, if you dont consider the possibility that you might have setbacks, then those setbacks are harder to deal with, Dr. Martin told the New York Times.. Being social is critical. Having a strong social ...
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Like most complex phenotypes, exceptional longevity is thought to reflect a combined influence of environmental (e.g., lifestyle choices, where we live) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity in 801 centenarians (median age at death 104 years) and 914 genetically matched healthy controls. Using these data, we built a genetic model that includes 281 single nucleotide polymorphisms (SNPs) and discriminated between cases and controls of the discovery set with 89% sensitivity and specificity, and with 58% specificity and 60% sensitivity in an independent cohort of 341 controls and 253 genetically matched nonagenarians and centenarians (median age 100 years). Consistent with the hypothesis that the genetic contribution is largest with the oldest ages, the sensitivity of the model increased in the independent cohort with older and older ages (71% to classify subjects with an age at death>102 and 85% to classify ...
TY - JOUR. T1 - Misexpression screen delineates novel genes controlling Drosophila lifespan. AU - Paik, Donggi. AU - Jang, Yeo Gil. AU - Lee, Young Eun. AU - Lee, Young Nam. AU - Yamamoto, Rochelle. AU - Gee, Heon Yung. AU - Yoo, Seungmin. AU - Bae, Eunkyung. AU - Min, Kyung Jin. AU - Tatar, Marc. AU - Park, Joong Jean. N1 - Funding Information: We thank Dr. Saitoe for CS10 flies, Dr. Monnier for da-GS-Gal4 flies, Szeged Stock Center for some EP lines, and Bloomington Stock Center for Hsp70-Gal4 and S106-GS-Gal4 flies. We also thank Dr. Silverman for his comments on this manuscript. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 20110028200 ). Work from the laboratory of M. Tatar was supported through the National Institute of Aging, NIH (USA) by R01AG024360 and R01AG031152 , and by the Glenn Medical Foundation and the Ellison Medical Foundation . PY - 2012/5. Y1 - 2012/5. N2 - In an initial preliminary screen we ...
In this work, the physical and chemical environmental determinants affecting wine yeast chronological life span (CLS) were analyzed. We have determined that heat and a low pH shortened the maximum CLS, while a hyperosmotic environment extends it (see Figure1). However, a low pH extends the mean life span. Natural grape juices have a low pH, so wine yeasts are well adapted to it, which may benefit cell survival as long as nutrients are present. Once resources have been exhausted, cells may find it harder to keep a balance with an environment that has a lower pH than the cytosol. Intracellular pH is around 5.5 in the stationary phase[27], so this may benefit long-term survival in a higher pH medium which is not so energy-demanding. Osmotic stress has been described to extend longevity in laboratory strains[28], which may be a case of stress cross protection, or hormesis, when a stress condition protects against subsequent stress conditions. Hyperosmotic stress triggers glycerol biosynthesis, a ...
University have found that a longevity gene helps to slow age ... (CETP) gene variant as a longevity gene in a population of ... study hypothesized that the CETP longevity gene might also be associated ...
Longevity - MedHelps Longevity Center for Information, Symptoms, Resources, Treatments and Tools for Longevity. Find Longevity information, treatments for Longevity and Longevity symptoms.
Potentially interested parties should note that participation in the Global Longevity project is subject to limitations imposed by applicable securities laws in various jurisdictions.. Potential investors should note that participation in the Global Longevity Sale is subject to limitations imposed by applicable securities laws in various jurisdictions. The following does neither constitute an offer to buy or to subscribe for the Potentially interested parties should note that participation in the Global Longevity project is subject to limitations imposed by applicable securities laws in various jurisdictions.. Potential investors should note that participation in the Global Longevity project Sale is subject to limitations imposed by applicable securities laws in various jurisdictions. The following does neither constitute an offer to buy or to subscribe for the Global Longevity project. Investors should make their decision to buy or to subscribe to Global Longevity project.. Investors are ...
How to Live a Long Life. There are many uncertainties in life, and no one can predict how long they will live. However, taking good care of yourself can help to increase your chances of living a long life. Take good care of your physical...
MIT biologists have discovered an unexpected effect of a ketogenic, or fat-rich, diet: They showed that high levels of ketone bodies, molecules...
Coronary heart disease (CHD) is the largest contributor to morbidity and mortality in the Western world and is associated with high-calorie diet, high body mass, and a variety of other factors. CHD can lead to myocardial infarction (MI) and other embolic events. A growing body of evidence suggests that relatively low caloric intake in the diets of a variety of animals increases longevity and preliminary evidence among humans indicates that such caloric restriction reduces risk factors for CHD, including cholesterol levels, blood pressure, glucose, and obesity. Caloric restriction has also been shown to alter the expression of certain genes, especially the forkhead box (FOX) O and sirtuin (SIRT) genes whose over-expression has been shown to increase longevity in animal models. Extended avoidance of caloric intake, also called fasting or short-term starvation, has been shown to increase expression of the FOXA genes that have similar sequence and function as the FOXO genes and that have been shown ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The lipid composition of cell membranes is linked to metabolic rate and lifespan in mammals and birds but very little information is available for fish. In this study, three fish species of the short-lived annual genus Nothobranchius with different maximum lifespan potential (MLSP) and the longer-lived outgroup species Aphyosemion australe were studied to test whether they conform to the predictions of the longevity- homeoviscous adaptation (LHA) theory of ageing. Lipid analyses were performed in whole-fish samples and the peroxidation index (PIn) for every phospholipid (PL) class and for the whole membrane was calculated. Total PL content was significantly lower in A. australe and N. korthausae, the two species with the highest MLSP, and a negative correlation between membrane total PIn and fish MLSP was found, meaning that the longer-lived fish species have more saturated membranes and, therefore, a lower susceptibility to oxidative damage, as the LHA theory posits.. ...
Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally long lives. Using data from the Long Life Family Study (LLFS), we sought to replicate these findings and extend them to include a larger number of disease‐specific risk alleles. To accomplish this goal, we built a genetic risk score for each of four age‐related disease groups: Alzheimers disease, cardiovascular disease and stroke, type 2 diabetes, and various cancers and compared the distribution of these scores between older participants of the LLFS, their offspring and their spouses. The analyses showed no significant differences in distribution of the genetic risk scores for cardiovascular disease and stroke, type 2 diabetes, ...
The Gompertz-Makeham law states that death rate is a sum of age-independent component (Makeham term) and age-dependent component (Gompertz function), which increases exponentially with age. The compensation law of mortality (late-life mortality convergence) states that the relative differences in death rates between different populations of the same biological species are decreasing with age, because the higher initial death rates are compensated by lower pace of their increase with age. The Late-life mortality deceleration law states that death rates stop increasing exponentially at advanced ages and level-off to the late-life mortality plateau. An immediate consequence from this observation is that there is no fixed upper limit to human longevity - there is no special fixed number, which separates possible and impossible values of lifespan. This challenges the common belief[1][2] in existence of a fixed maximal human life span. Biodemographic studies found that even genetically identical ...
This volume contributes to the development of scientific knowledge related to the slowing down of the pace of progression of morbidity with mortality declines at older ages. Research findings reported are instrumental in the realisation of the long-term dream of healthy longevity.Zeng, Yi is the author of Healthy Longevity in China, published 2008 under ISBN 9781402067518 and ISBN 1402067518. [read more] ...
Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is ca …
Pterostilbene is a compound found primarily in blueberries, the focus of intense longevity research due to its ability to activate three key molecular pathways involved in aging.
Few studies have examined how various lifestyle factors in midlife predict longevity, and none of these studies have examined the impact of physical fitness. The present study aimed to examine longevity in relation to smoking, overweight and physical fitness. We prospectively studied longevity (defined as reaching at least 85 years of age) in relation to smoking status, body mass index and physical fitness in 821 healthy men between 51 and 59 years of age. Of these, 369 were smokers, 320 were overweight, and 31 were obese. The associations were adjusted for age, systolic blood pressure and cholesterol level, using multivariate logistic regression analysis. Deaths were registered until the 31st of December, 2006. Physical fitness was measured as the total work performed in a maximal exercise tolerance bicycle test. 252 men survived to the age of 85 years (30.7%). Smoking status was significantly and independently related to longevity; 37.2% of the non-smokers survived to the age of 85, and 22.8% of the
Stress theory is the elephant in the living room of medicine because it provides the simplest explanation of physiology, pathology, and stress. It postulates an extracellular stress mechanism that converts genetic information into embryological development, whereupon DNA resumes quiescence while the stress mechanism remains active to repair tissues and regulate physiology. Environmental stresses induce stress mechanism hyperactivity that manifests as disease.The recent discovery of this mechanism will elevate medicine from an art based on experiment to a true science guided by theory, and revolutionize medical treatments. Stress theory exemplifies the pattern of scientific progress described by Thomas Kuhn.(1) Important new theories appear long before evidence becomes available to confirm them. A theory is useless without a testable mechanism that explains how it works, so stress theory inspired an international search for the theoretical stress mechanism that was abandoned after 30 years of ...
Longevity risk is a significant issue for annuity providers and pension fund managers. Specifically, they face major challenges in managing their long- dated liabilities and longevity risks, due to a lack of appropriate assets in the form of long-dated and suitable longevity bonds. This thesis investigates immunisation strategies for longevity risk hedging from the perspective of a fund manager and annuity provider. The thesis contributes new insights and methods for the immunisation of annuity portfolios against both interest rate and mortality risks. Methods for effectively selecting optimal assets to hedge both risks are proposed and assessed, using coupon bonds, annuity bonds and longevity bonds. A comparison of delta-gamma and duration-convexity hedging concludes that, to hedge against both interest rate and mortality risks, delta-gamma hedging requires both longevity bonds and fixed-income securities. A risk analysis to identify the optimal asset allocation for these risks demonstrates the ...
We bring you this episode of #WhenIm64 with a heavy heart. Harry Wittenberg passed away after a long battle with #ALS last weekend, and we honor his memory. Listen to our podcast learn how his ALS changed his life: longevity.stanford.edu/caregi… Read his blog: harrywittenberg.com. About a day ago from Stanford Center on Longevitys Twitter via Twitter Web App ...
Dear Springtime, Thank you so much for making Longevity. My older dog, Mia, an eleven year old Terrier mix, was really showing her age. She was limping from a leg injury the vet was uncertain would ever heal. However, after just a few weeks on Longevity (which she loves) I started seeing the puppy return in my dog. She has lost weight, can exercise more, and there is no limp whatsoever. And, here is the real proof. My dog has always had one ear that stays half down. After a few weeks on Longevity I started noticing that both her ears stood straight up. I first wondered what was going on, that Mia looked different; her ears seemed to be quite large. After a few days of this, I actually could feel that the cartilage on her ears was thicker. It is amazing. My sister and friends were laughing a little as she looks like she may take off with the next wind, but I am just thrilled to have my little dog with me as long as possible. Thanks again, Springtime - keep up the fantastic work! Your friend
Downloadable! This paper discusses what is longevity risk, why it is important, approaches used by the West to manage longevity risk and what lessons can be learnt by Asian countries from the experiences of the West. Increasing and uncertain longevity has emerged as a key risk affecting individuals, pension plans, insurers and governments in both the developed and emerging world. I discuss progress in the field of longevity modelling and the merits as well as drawbacks of these models. In Western countries, attempts have been made by capital market and governments to deal with longevity risk, but the availability of solutions remain limited. Further developments should focus on creating a set of instruments that are effective, economically affordable, and transparently priced. It is important to understand, measure, and manage longevity risk. Moreover, further pension reforms are needed to address the root of the problem. For Asian countries, the experience of the West provides ample guidance in
Growth hormone signaling influences longevity but the mechanism through which decreased GH action extends lifespan in mice is unknown. It is likely that the key to understanding this phenomenon, and the process of aging itself, is to understand the alterations in metabolism caused by decreased GH action. We investigated changes in energy metabolism in long-lived mice, in hope that these findings can suggest means of improving human health and longevity. These studies consisted of three projects. The influence of altered GH signaling on metabolism was tested by monitoring oxygen consumption, respiratory quotient, and heat production. Intriguingly, long-lived mice have increased oxygen consumption, and decreased respiratory quotient; while short lived mice had opposite effects. These data indicate that decreased GH signaling associates with increased metabolism per unit of body weight and may beneficially affect mitochondrial flexibility by increasing the capacity for fat oxidation; while GH excess
Animals with few predators such as tortoises or animals on secluded islands with few or no predators such as new zealands tuatara generally have longer life spans because they retain reproductive capability throughout their life. an opossum dies in 3 or 4 years because have so many predators that they can often only life long enough to reproduce. this is explained in Genome the author escapes me but I suggest you check it ...
A whole genome study discovered a number of genetic characteristics unique to those who live well past 100ljsphotography/Depositphotos VIEW 1 IMAGES In the most detailed genomic study ever conducted of individuals over the age of 100 years, researchers have homed in on several particular genetic characteristics that seem to confer protection from age-related diseases. Gene variants improving DNA repair processes were particularly prominent in this cohort of supercentenarians. If you eat well, exercise frequently and avoid those detrimental vices, you can reasonably hope to live a long and healthy life. Of course, many age-related diseases seem almost inevitable, whether they catch up with you in your 80s or your 90s. But some people show a propensity for extreme longevity, living healthily well past the age of 100. Research has shown those who live beyond the age of 100 tend to present extraordinarily healthy signs of aging. They are less likely to have been hospitalized in earlier life and have ...
Hi there! Just a 2 cents. This a great study, best Christmas present whole year.. This is an interesting finding, but, as for the epigenetic clock used to assess aging in individuals, it will likely require the work of many research groups and many years to build a firm understanding as to why this correlation exists. Nonesuch, I understand the questioning Reason, but the answer is there already, no need to build many research groups, instead we must Attack it and fix it, just like your website, fightaging. We have to be more dire about aging, it cant be passive anymore. Aging/death is very dire. A call to action rather than information/research for research(ing)/more infos and less action on it. (just like your call to donate to make therapies come sooner). 99% studies are informative/passive research for researching and giving potential therapeutic leads...but many offer nothing of such and are, indeed, Just informational and more research purposes. There is a large body of data ...
HOWARD S. FRIEDMAN is Distinguished Professor at the University of California in Riverside. LESLIE R. MARTIN is Professor of Psychology at La Sierra University, and Research Psychologist at UC Riverside. They met when Leslie began graduate study in 1991 at UC Riverside, where she became a key and continuing associate in Howards then-launching lifespan longevity studies. Here are some facts about their work, their interests, and their qualifications. Their scientific research on health and longevity has been published in over 150 influential and often-cited scientific articles and chapters in leading books and scientific journals. In addition, Professor Friedman has authored or edited ten academic books about health and one prior trade book, The Self-Healing Personality.. His textbook on Personality is now in its 5th edition. He served as Editor-in-chief of the Encyclopedia of Mental Health, which received recognition as a Best Reference Source of 1998″ from Library Journal. His edited book, ...