OBJECTIVE To determine whether adult cochlear implant (CI) users with superior canal dehiscence syndrome (SCDS) or asymptomatic superior semicircular canal dehiscence (SCD) have different surgical, vestibular, and audiologic outcomes when compared to CI users with normal temporal bone anatomy. METHODS A retrospective single institution review of CI users with either superior semicircular canal dehiscence syndrome or asymptomatic superior semicircular canal dehiscence identified eight post-lingually deafened adults with unilateral or bilateral cochlear implantation between 2006 and 2010. Preoperative and postoperative speech perception scores as well as medical and epidemiological data were recorded and analyzed. RESULTS One patient with superior canal dehiscence syndrome and seven patients with asymptomatic superior semicircular canal dehiscence were identified, representing 7% or 8/113 of CI patients that fulfilled selection criteria. Average dehiscence length was 3.3 mm ± 0.79 SEM. Three patients

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal ...

TY - JOUR. T1 - Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma. AU - Chamseddin, Bahir H.. AU - Lee, Eunice E.. AU - Kim, Jiwoong. AU - Zhan, Xiaowei. AU - Yang, Rong. AU - Murphy, Kathleen M.. AU - Lewis, Cheryl. AU - Hosler, Gregory A.. AU - Hammer, Suntrea T.. AU - Wang, Richard C.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1) expression remains controversial, and glucose transporter 1 (GLUT1) expression has never been examined in ASCC. Covalently closed circular RNAs have recently been shown to be widespread in cancers and are proposed to be biomarkers. We discovered HPV16 expresses a circular E7 RNA (circE7) which has not been assessed as a potential biomarker. A retrospective, translational case series at UT Southwestern was conducted to analyze PD-L1, GLUT1, ...

A sphincter is a circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological Anal sphincter repair is an operation performed on the back passage to repair the gap in the damaged anal sphincter muscle. The external anal sphincter is composed of skeletal muscle, is under voluntary control, (but not under anesthesia when the muscles relax). Sphincter muscle, any of the ringlike muscles surrounding and able to contract or close a bodily passage or opening. One of the most important human sphincter muscles The thickness of the anal sphincter muscles and the length of Normal Anal Sphincter Anatomy and Age- and Sex-related Variations at High-Spatial-Resolution ...

Rectal tightness and muscle spasm. What is the treatment for Levator Ani Syndrome?. The common types of treatment for levator ani syndrome are usually muscle relaxants, hot baths, and proper diet and exercise. In most cases, there is an underlying element of chronic stress and anxiety which causes these muscles to tighten up and spasm. This pelvic floor muscle tension causes pain and burning. In order for most cases of levator ani syndrome to be resolved, trigger point therapy or internal massage on the levator ani/rectal muscles can bring great relief. The treatment itself can be very painful, but the overall relief from treatment can be felt almost immediately. ...

Recurrent Hypopharyngeal Squamous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Laryngeal Verrucous Carcinoma Recurrent Lip and Oral Cavity Squamous Cell Carcinoma Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma Recurrent Oral Cavity Verrucous Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma Recurrent Salivary Gland Carcinoma Salivary Gland Squamous Cell Carcinoma Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary Stage IV Hypopharyngeal Squamous Cell Carcinoma Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma Stage IVA Laryngeal Squamous Cell Carcinoma Stage IVA Laryngeal Verrucous Carcinoma Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma Stage IVA Major Salivary Gland Carcinoma Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma Stage IVA Oral Cavity Verrucous ...

OBJECTIVE To evaluate the impact of transanal endoscopic microsurgery (TEM) on postoperative anal function and quality of life in patients with benign rectal tumor and early rectal cancer. METHODS Clinical data of 50 patients with rectal adenoma and early rectal cancer undergoing transanal endoscopic microsurgery in our hospital from October 2008 to June 2013 were retrospectively analyzed. Anorectal manometry, endorectal ultrasonography (ERUS), the fecal incontinence severity index (FISI), and the physical and mental health status scores (SF-36) were used to evaluate preoperative and postoperative anorectal function and quality of life. RESULTS Anorectal manometry indicated anal resting pressure (ARP), maximum squeeze pressure (MSP), rectal volume at sensory threshold(RVST), maximum tolerable volume(MTV) decreased significantly at the first month after surgery (P|0.05). MSP returned to preoperative level at the 3rd month (P|0.05). ARP and MTV returned to normal values at the 6th month (P|0.05). RVST

PURPOSE: Disconnection of an ileal pouch-anal anastomosis with repeat ileal pouch-anal anastomosis has been proposed for treatment of ileal pouch-anal anastomosis failure caused by septic or functional complications. We report our experience with repeat ileal pouch-anal anastomosis, and document functional outcome and quality of life.. METHODS: Of 101 patients undergoing laparotomy, ileoanal disconnection, and repeat ileal pouch-anal anastomosis, 80 were referred from other institutions. Indications included: chronic anastomotic leak (n=27), perineal or pouch-vaginal fistula (n=47), anastomotic stricture (n=22), dysfunction/long efferent limb of S-pouch (n=36), and previous ileal pouch-anal anastomosis excision or exclusion (n=6). In 64 cases a "septic" indication was observed. Pathologic features of Crohn's disease were present in 4 patients preoperatively and 15 more after repeat ileal pouch-anal anastomosis. Four patients had clinical features of Crohn's disease.. RESULTS: Three patients had ...

In previous studies, the frequency of PSN in LC-BPPV has been reported to vary from 40.1% to 76%, and to increase to 56.2-96% after mild head shaking [3,4,10]. In the present study, this ratio for patients showing PSN was only 16.8%, which is considerably lower than in previous reports. Two situations at the outpatient clinic can account for this difference. First in the present study, the time devoted at the clinic to examining spontaneous nystagmus was relatively short, although it was sufficient to detect apparent nystagmus (minimum 10 seconds). Second, and more important, the head position of the patients was not precisely controlled. The existence and direction of PSN were observed immediately after a patient sat on a chair with his/her head roughly earth vertical. Patients with LC-BPPV naturally prefer to bend their head slightly forward, since this posture minimizes movement of otolith particles in the lateral semicircular canal. Otherwise, patients favor at least having the head fixed in ...

TY - JOUR. T1 - Long-Term Patient-Reported Outcomes after Surgery for Superior Canal Dehiscence Syndrome. AU - Alkhafaji, Mohammed S.. AU - Varma, Sanskriti. AU - Pross, Seth E.. AU - Sharon, Jeffrey D.. AU - Nellis, Jason C.. AU - Della Santina, Charles C.. AU - Minor, Lloyd B.. AU - Carey, John P.. PY - 2017/10/1. Y1 - 2017/10/1. N2 - Objective: Evaluate the long-term patient-reported outcomes of surgery for superior canal dehiscence syndrome (SCDS). Study Design: Cross-sectional survey. Setting: Tertiary referral center. Patients: Adults who have undergone surgery for SCDS with at least 1 year since surgery. Main Outcome Measure(s): Primary outcome: change in symptoms that led to surgery. Secondary outcomes: change in 11 SCDS-associated symptoms, change in psychosocial metrics, and willingness to recommend surgery to friends with SCDS. Results: Ninety-three (43%) respondents completed the survey with mean (SD) time since surgery of 5.3 (3.6) years. Ninety-five percent of respondents reported ...

TY - JOUR. T1 - Risk factors for the recurrence of obstetrical anal sphincter injury and the role of a mediolateral episiotomy. T2 - an analysis of a national registry. AU - van Bavel, J.. AU - Ravelli, A. C.J.. AU - Abu-Hanna, A.. AU - Roovers, J. P.W.R.. AU - Mol, B. W.. AU - de Leeuw, J. W.. N1 - © 2020 Royal College of Obstetricians and Gynaecologists.. PY - 2020/4/3. Y1 - 2020/4/3. N2 - Objective: The assessment of risk factors, including mediolateral episiotomy (MLE), for the recurrence of obstetric anal sphincter injury (rOASI). Design: Population-based cohort study. Setting: Data from the nationwide database of the Dutch Perinatal Registry (Perined). Population: A cohort of 391 026 women at term, of whom 9943 had an OASI in their first delivery and had a second vaginal delivery of a liveborn infant in cephalic position. Methods: Possible risk factors were tested for statistical significance using univariate and multivariate logistic regression analysis. Main outcome measures: Rate of ...

150 COLONIC AND ANORECTAL DISEASES Harrison's Manual of Medicine 150 COLONIC AND ANORECTAL DISEASES Irritable Bowel Syndrome (IBS) Diverticular disease Intestinal Pseudoobstruction Vascular Disorders (Small and Large Intestine) Colonic Angiodysplasia Anorectal Diseases Bibliography Irritable Bowel Syndrome (IBS) Characterized by altered bowel habits, abdominal pain, and absence of detectable organic pathology. Most common GI disease in…

TY - JOUR. T1 - Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. AU - Gol Choe, Jae. AU - Kim, Yu Ri. AU - Kim, Ki Nam. AU - Choo, Hyo Jung. AU - Shin, Jae Hoon. AU - Lee, Yong Jin. AU - Chung, June Key. AU - Kim, Meyoung Kon. PY - 2005/12. Y1 - 2005/12. N2 - The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.. AB - The sodium/iodide symporter ...

Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cells (8305c cells). To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis. Apoptosis was analyzed with Hoechst 33342 staining and DNA ladder formation assay. 8305c cells became radiosensitive when glycerol was added to culture medium before X-ray irradiation. Apoptosis was induced by X-rays in the presence of glycerol. However, there was little apoptosis induced by X-ray irradiation or glycerol alone. The binding activity of whole cell extracts to bax promoter region was induced by X-rays in the presence of glycerol but not by X-rays alone. These findings suggest that glycerol is

TY - JOUR. T1 - Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis. AU - Shen, Bo. AU - Fazio, Victor W.. AU - Remzi, Feza H.. AU - Brzezinski, Aaron. AU - Bennett, Ana E.. AU - Lopez, Rocio. AU - Hammel, Jeffrey P.. AU - Achkar, Jean Paul. AU - Bevins, Charles L.. AU - Lavery, Ian C.. AU - Strong, Scott A.. AU - Delaney, Conor P.. AU - Liu, Wendy. AU - Bambrick, Marlene L.. AU - Sherman, Kerry K.. AU - Lashner, Bret A.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/1. Y1 - 2006/1. N2 - Background & Aims: Although pouchitis is considered the most common adverse sequela of ileal pouch-anal anastomosis (IPAA), inflammatory and noninflammatory conditions other than pouchitis are increasingly being recognized. The risk factors for these non-pouchitis conditions, including Crohn's disease (CD) of the pouch, cuffitis, and irritable pouch syndrome (IPS), have not been studied. The aim of this study was to ...

To compare volumetric-modulated arc therapy (RapidArc) plans with conventional intensity-modulated radiation therapy (IMRT) plans in anal canal cancers. Ten patients with anal canal carcinoma previously treated with IMRT in our institution were selected for this study. For each patient, three plans were generated with the planning CT scan: one using a fixed beam IMRT, and two plans using the RapidArc technique: a single (RA1) and a double (RA2) modulated arc therapy. The treatment plan was designed to deliver in one process with simultaneous integrated boost (SIB) a dose of 59.4 Gy to the planning target volume (PTV2) based on the gross disease in a 1.8 Gy-daily fraction, 5 days a week. At the same time, the subclinical disease (PTV1) was planned to receive 49.5 Gy in a 1.5 Gy-daily fraction. Plans were normalized to 99% of the PTV2 that received 95% of the prescribed dose. Planning objectives were 95% of the PTV1 will receive 95% of the prescribed dose and no more than 2% of the PTV will receive more

Traditional Chinese medicine believes that hemorrhoids are mostly caused by rheumatism, dryness, heat, and pulsation of evil wounds, so that qi and blood are stagnant and congregate in the anus; anal fissures are mostly caused by dry fire, damp heat accumulating in the anus, or blood heat and intestinal dryness; anal fistula It is formed by producing damp heat and fire poison in the body and betting on the anus. It can be seen from the above that most of anorectal diseases are related to damp heat, and damp heat mainly comes from diet, so Chinese medicine emphasizes that diet should be controlled.. There are two reasons for anorectal disease:. 1. Disorders of life patterns. 1. Excessive play: Most people think that they are busy with work and do not have time to entertain with family and friends. They should gather together during holidays and have fun. As a result, playing all night long, sleeping during the day, the yin and yang are reversed, disrupting the original rhythm of life, leading to ...

The standard treatment of rectal adenocarcinoma is total mesorectal excision (TME). The technique involves a low anterior rectal or colo-anal resection, very often associated with a protective stoma or abdominal-perineal resection with permanent colostomy. Transanal endoscopic microsurgery (TEM) allows access to tumors up to 20 cm from the anal margin, with minimal postoperative morbidity and mortality. Recent studies of T1 rectal adenocarcinomas consider TEM to be the technique of choice. However the treatment of T2 rectal cancers remains controversial. Chemotherapy and radiotherapy (CT/RT) has achieved a concomitant reduction in local recurrence and an increase in survival.. Hypothesis: Patients with rectal adenocarcinoma less than 10 cm from the anal margin and up to 4 cm in size, staged after endorectal ultrasound and MRI as T2 or superficial T3 N0-M0-N0-M0, who underwent surgery after preoperative local chemoradiotherapy (TEM), achieve effective results in terms of local recurrence similar ...

Anal high-risk human papillomavirus infection and high-grade anal intraepithelial neoplasia detected in women and heterosexual men infected with human immunodeficiency virus Sumanth Gandra, Aline Azar, Mireya WessolosskyDivision of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA, USABackground: Although anal high-risk human papillomavirus (HR-HPV) infection and anal cytological abnormalities are highly prevalent among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM), there are insufficient data on these abnormalities among HIV-infected heterosexual men (HSM) and women. In this study, we evaluated the prevalence of anal HR-HPV, cytological abnormalities, and performance of these screening tests in detecting high-grade anal intraepithelial neoplasia (AIN2+) among our cohort of HIV-infected MSM and non-MSM (HSM and women).Methods: A single-center, retrospective cohort study was conducted with HIV-infected individuals who underwent anal

Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated ...

Anal HPV infection can be a risk factor for anal cancer, which is a common non-AIDS-defining cancer among HIV-infected MSM. Screening for anal cancer is not widely available and can be difficult to implement. People who receive the FDA-approved quadrivalent HPV vaccine, Gardasil, may have a reduced risk of developing anal HPV infection, which may in turn reduce the risk of developing anal cancer. The purpose of this study is to evaluate the effectiveness of the quadrivalent HPV vaccine, Gardasil, at reducing the incidence of anal HPV infections in HIV-infected MSM and HIV-infected women.. This study enrolled HIV-infected MSM and HIV-infected women. Participants were randomly assigned to receive the HPV vaccine or a placebo vaccine. At the screening study visit, participants underwent a physical examination, blood collection, anal swab procedure, oral examination, questionnaires, a high-resolution anoscopy (HRA), and if female, a pregnancy test, vaginal swab, and gynecologic exam. At the entry ...

TY - JOUR. T1 - Nasal NK/T cell lymphoma mimicking a squamous cell carcinoma. T2 - A case report. AU - Valiathan, Manna. AU - Rao, Ravikala V.. AU - Rao, Lakshmi. AU - Jaffe, Elaine S.. AU - Pillai, Suresh. PY - 2005. Y1 - 2005. N2 - A 48 year old female presented with extensive ulceration of the nasal septum of 8 months duration. Investigations confirmed the local nature of the disease. A biopsy revealed large zones of ischemic necrosis and abnormal lymphoid cells invading vessel walls and glandular structures. Florid squamous metaplasia, and pseudoepitheliomatous hyperplasia of mucosal epithelium mimicked squamous cell carcinoma and necrotising sialometaplasia. Immunohistochemistry and insitu hybridization confirmed the diagnosis of an EBV positive, Nasal NK/T cell lymphoma. A Pubmed/Medline search suggests that this is the first documented case from India.. AB - A 48 year old female presented with extensive ulceration of the nasal septum of 8 months duration. Investigations confirmed the ...

With the aim of determining the market potential, the overall market is analyzed with respect to the parameters included in the Porter's Five Force Model. On top of that, a SWOT analysis is also done, as a result of which the report is able to provide a precise knowledge of the Sacral Nerve Stimulation market. The exhaustive analysis of the market helps identify and highlight its main strengths, weaknesses, opportunities, and risks.. Complete Report Details @ https://www.wiseguyreports.com/reports/4009659-global-sacral-nerve-stimulation-market-size-status-and-forecast-2019-2025 Table of Contents -Analysis of Key Points. 1 Sacral Nerve Stimulation Market Overview 2 Manufacturers Profiles 3 Global Sacral Nerve Stimulation Market Competition, by Players 4 Global Sacral Nerve Stimulation Market Size by Regions 5 North America Sacral Nerve Stimulation Revenue by Countries 6 Europe Sacral Nerve Stimulation Revenue by Countries 7 Asia-Pacific Sacral Nerve Stimulation Revenue by Countries 8 South ...

TY - JOUR. T1 - Sonographic findings predictive of central lymph node metastasis in patients with papillary thyroid carcinoma. T2 - Influence of associated chronic lymphocytic thyroiditis on the diagnostic performance of sonography. AU - Yoo, Yeon Hwa. AU - Kim, Jeong Ah. AU - Son, Eun Ju. AU - Youk, Ji Hyun. AU - Kwak, Jin Young. AU - Kim, Eun Kyung. AU - Park, Cheong Soo. PY - 2013/12/1. Y1 - 2013/12/1. N2 - Objectives-To analyze sonographic findings suggesting central lymph node metastasis of papillary thyroid carcinoma and to evaluate the influence of associated chronic lymphocytic thyroiditis on the diagnostic performance of sonography for predicting central lymph node metastasis. Methods-A total of 124 patients (101 female and 23 male; mean age, 47.5 years; range, 21-74 years) underwent sonographically guided fine-needle aspiration in central lymph nodes from January 2008 to July 2011. Sonographic features of size, shape, margin, thickening of the cortex, cortical echogenicity, presence of ...

Case Reports in Surgery is a peer-reviewed, Open Access journal that publishes case reports related to all aspects of surgery. Topics include but are not limited to oncology, trauma, gastrointestinal, vascular, and transplantation surgery.

Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IV Salivary Gland Cancer Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of ...

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IVA Salivary Gland Cancer Stage IVA Squamous Cell Carcinoma of the Larynx Stage IVA Oral Cavity Squamous Cell Carcinoma Stage IVA Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVA ...

Discussion: Squamous cell carcinoma is the most common malignant tumor of the ocular surface8. Spindle cell carcinoma is a poorly differentiated variant of squamous cell carcinoma that rarely occurs in the conjunctiva 3,4,5,6,7. Cervantes et al. reported a total 287 cases of squamous cell carcinoma of conjunctiva, in which only two cases were documented as spindle cell carcinoma11. Surgical excision with or without cryotherapy and radiotherapy remains widely accepted treatment for squamous cell carcinoma of the conjunctiva9,10 ...

Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue (or in cells that display epithelial characteristics) that bear microscopic resemblance to lymphoepithelioma (nasopharyngeal carcinoma). There is considerable variation in the classification of LELC-while it is perhaps most commonly considered a subtype of squamous cell carcinoma, it can also be classified as a form of large cell carcinoma (i.e. when occurring in the lung), and can be considered as a separate, unique entity. In most anatomical sites, many cases are associated with the Epstein-Barr virus. In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator. Nasopharyngeal carcinoma Lymphoepithelioma Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. ...

TY - JOUR. T1 - Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma. AU - Eggers, Scott D.Z.. AU - Salomao, Diva R.. AU - Dinapoli, Robert P.. AU - Vernino, Steven. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2001. Y1 - 2001. N2 - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.. AB - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are ...

The Division of Colorectal Surgery specializes in the treatment anal and rectal cancer and well as a wide variety of benign colorectal and anorectal conditions. Our physicians perform office, outpatient and inpatient surgical procedures for anorectal conditions including hemorrhoids, abscess, fissure, fistula and prolapse. For complex anorectal disease conditions, our team uses both perineal and abdominal procedures to achieve disease and symptom control while maintaining sphincter function and preservation of quality of life.

Merkel cell carcinoma is a rare and aggressive skin malignancy that arises from primary neural cells and has a tendency for local recurrence and regional lymph node metastases. There are only a few cases in the literature reporting metastases of Merkel cell carcinoma to the gastrointestinal tract. We present a 70 year old Caucasian female with distant history of Merkel cell carcinoma who presented with iron-deficiency anemia. Colonoscopy performed later for the evaluation of anemia revealed 1 cm polyp in ascending colon which turned out to be the recurrence of Merkel cell carcinoma. Metastatic Merkel cell carcinoma to the gastrointestinal tract or any other organ should be considered in patients with a history of Merkel cell carcinoma.

TY - JOUR. T1 - Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer cells. AU - Chin, Li Han. AU - Hsu, Sung Po. AU - Zhong, Wen-Bin. AU - Liang, Yu Chih. PY - 2016. Y1 - 2016. N2 - Anaplastic thyroid cancer (ATC) is among the most aggressive types of malignant cancer. Epidermal growth factor (EGF) plays a crucial role in the pathogenesis of ATC, and patients with thyroid carcinoma typically exhibit increased cysteine-rich protein 61 (Cyr61). In this study, we found that EGF treatment induced cell migration, stress fiber formation, Cyr61 mRNA and protein expressions, and Cyr61 protein secretion in ATC cells. The recombinant Cyr61 protein significantly induced cell migration; however, inhibition of Cyr61 activity by a Cyr61-specific antibody abrogated EGF-induced cell migration. EGF treatment also affected epithelial-to-mesenchymal transition (EMT)-related marker protein expression, as evidenced by an increase in vimentin and ...

Sacral nerve stimulation using a tined lead as an extended testing phase to evaluate the predictive value of this form of testing by comparing the long-term (6 months) response to permanent sacral nerve stimulation in the groups classified by the test.. The tined lead test stimulation (TiLTS) is of 6 weeks duration and involves an 'active' period of 2 weeks of active subsensory sacral nerve stimulation, and a placebo or 'sham' period of 2 weeks of pretend subsensory sacral nerve stimulation. These periods are around a central 2 weeks of 'no' testing (a washout period) giving a total of 6 weeks in this testing phase. Study participants are randomised into either group A or B who receive the active and sham testing in reversed orders, and so blinding both the assessment researchers and participants to the order of active and sham testing. Participants will identify on a visual analogue scale of 0-100 on how much they feel each 2 week period has improved their symptoms compared to baseline. ...

HIV infected men having sex with men (MSM) are at increased risk of developing anal cancer compared to the general population and the incidence continues to increase despite better control of HIV infection with HAART (Highly Active Anti-Retroviral Therapy). The causative agent is known to be Human Papilloma Virus infection which can lead to dysplastic changes in the anus, detectable by High Resolution Anoscopy with biopsies. The analysis of the abnormal tissue can then be graded as Anal Intraepithelial Neoplasia 1 to 3, with AIN 2 or 3 considered as high grade dysplasia. These lesions are cancer precursors, but the proportion of lesions progressing to invasive anal cancer and the time to event are unknown. There is currently no recognized treatment to offer as standard of care although it is of general belief that treating these lesions, as it is done for women with CIN 2 and 3 (Cervical Intraepithelial Neoplasia) could help decrease the number of progressions to invasive anal cancer in MSM ...

to the editor: Sebaceous cell carcinoma of the eyelid is the fourth most common malignancy in the periocular region in the United States (basal cell carcinoma, squamous cell carcinoma, and melanoma are the leading three causes) and the second most common malignancy in China (basal cell carcinoma is the leading cause).1,2 Diagnosis and therapy tend to be delayed because sebaceous carcinoma is often mistaken for benign entities such as chalazion, conjunctivitis, or blepharitis.3. A 74-year-old woman presented to her ophthalmologist with conjunctival erythema and slight tenderness of her upper eyelid. She was diagnosed with conjunctivitis and prescribed erythromycin 0.5% ophthalmic ointment. At her one-month follow-up visit, she continued to have erythema and had also developed a small tender papule. A diagnosis of chalazion was made, and the patient was instructed to continue her antibiotic ointment and to apply warm compresses four times daily to the eye. At her two-month follow-up visit, the ...

OUTLINE: This is a multicenter study.. Patients undergo anal swab collection at baseline to obtain samples for anal cytology, anal human papillomavirus (HPV) typing, and other HPV-related testing (e.g., HPV viral load). Digital rectal examinations (DRE) are also performed as part of the baseline physical examination. Female patients also undergo cervical swab collection for cervical HPV testing and cytology, as well as colposcopy (if available) of the cervix and vulvovaginal region to completely assess lower genital tract HPV-related lesions. At sites where high-resolution anoscopy (HRA) is available, patients are encouraged, but not required, to have an HRA with biopsy of any visualized lesions within 30 days of collection of the swabs.. After baseline assessments, patients undergo treatment with the investigative agent according to the study protocol requirements. If study treatment continues beyond 6 months, additional anal and cervical swabs are obtained for anal and cervical HPV and ...

1-3 It accounted for 0.005% of all cancers in the National Cancer Database from 1985 to 1995.4 A review of the Surveillance, Epidemiology, and End Results (SEER) cancer registry identifying patients with parathyroid carcinoma from 1988 to 2003 in the United States demonstrated a 60% rise in incidence of parathyroid carcinoma from 3.58 to 5.73 per 10 million.2 A review of the European Cancer registry from 1995 to 2002 demonstrated an incidence of 0.02% per 10 million among 27 European countries, emphasizing the rarity of this cancer.5 Approximately 1% of hyperparathyroidism is attributed to parathyroid carcinoma, and retrospective studies have demonstrated an even distribution between men and women.4 Benign parathyroid disease has a female predominance (3-4:1), occurring a decade later than parathyroid carcinoma which usually manifests at an average age of 48 years.1,3,6 Parathyroid carcinoma rarely occurs in children.7,8 ...

TY - JOUR. T1 - Diagnostic performance of FDG-PET/CT for cervical lymph node metastasis in patients with oral cancer. AU - Kubo, M.. AU - Terazawa, K.. AU - Otomi, Y.. AU - Shinya, Takayoshi. AU - Harada, M.. AU - Otsuka, H.. PY - 2015. Y1 - 2015. N2 - 18F-FDG PET/CT examinations are useful for the diagnosis of cervical lymph node metastasis. In this study, PET/CT was found to have a sensitivity of 73% and a specificity of 79%. Since inflammatory lymph nodes sometimes manifest false positive FDG findings, we should therefore carefully examine patients with cervical lymph node swelling and consider the anatomic location of both the primary lesion and cervical lymph nodes. Other morphological imaging modalities (CECT, MRI) may therefore also be necessary to obtain more precise anatomic information.. AB - 18F-FDG PET/CT examinations are useful for the diagnosis of cervical lymph node metastasis. In this study, PET/CT was found to have a sensitivity of 73% and a specificity of 79%. Since ...

Pudendal nerve entrapment (PNE), also known as Alcock canal syndrome, is an uncommon source of chronic pain, in which the pudendal nerve (located in the pelvis) is entrapped or compressed. Pain is positional and is worsened by sitting. Other symptoms include genital numbness, fecal incontinence and urinary incontinence. The term pudendal neuralgia (PN) is used interchangeably with "pudendal nerve entrapment", but a 2009 review study found both that "prevalence of PN is unknown and it seems to be a rare event" and that "there is no evidence to support equating the presence of this syndrome with a diagnosis of pudendal nerve entrapment," meaning that it is possible to have all the symptoms of pudendal nerve entrapment (otherwise known as pudendal neuralgia) based on the criteria specified at Nantes in 2006, without having an entrapped pudendal nerve. A 2015 study of 13 normal female cadavers found that the pudendal nerve was attached or fixed to the sacrospinous ligament in all cadavers studied, ...

The scariest rectal prolapse symptom is when the rectum, part of the lower intestine, falls out of the anal opening.. With rectal prolapse, the rectum can fail to come out at all, only appear with bowel movements or sneezing, or chronically protrude from the body at all times.. The symptoms of internal intussception rectal prolapse are a feeling of fullness, bloating, or internal discomfort, as the rectum slides out of its appointed position and falls against other internal organs.. With rectal prolapse, extreme pain and difficulties with bowel movements may also be noticed, especially if the rectum undergoes any torsion (twisting) during its collapse in any form of the rectal prolapse.. Other forms of rectal prolapse cause the protrusion of some or all of the rectum from the anal sphincter.. Other symptoms of rectal prolapse include bleeding or mucus discharge from the damaged tissue, loss of urge to defecate, and fecal incontinence.. Rectal prolapse that is protruding, will most likely look ...

Abdominoperineal Resection in Bangalore. Cost of Abdominoperineal Resection in Bangalore, View List of Best Reviewed Hospitals & Surgeons & Book Appointment, Patient Reviews, Abdominoperineal Resection Meaning, Risks, Side Effects & FAQ. | Practo

OUTLINE: This is a multicenter study.. Patients undergo anal swab collection at baseline to obtain samples for anal cytology, anal human papillomavirus (HPV) typing, and other HPV-related testing (e.g., HPV viral load). Digital rectal examinations (DRE) are also performed as part of the baseline physical examination. Female patients also undergo cervical swab collection for cervical HPV testing and cytology, as well as colposcopy (if available) of the cervix and vulvovaginal region to completely assess lower genital tract HPV-related lesions. At sites where high-resolution anoscopy (HRA) is available, patients are encouraged, but not required, to have an HRA with biopsy of any visualized lesions within 30 days of collection of the swabs.. After baseline assessments, patients undergo treatment with the investigative agent according to the study protocol requirements. If study treatment continues beyond 6 months, additional anal and cervical swabs are obtained for anal and cervical HPV and ...

The external anal sphincter (or sphincter ani externus ) is a flat plane of muscular fibers, elliptical in shape and intimately adherent to the skin surrounding the margin of the anus. The external anal sphincter measures about 8 to 10 cm in length, from its anterior to its posterior extremity, and is about 2.5 cm opposite the anus, when defecation occurs the sphincter muscle retracts. It consists of two strata, superficial and deep. The superficial, constituting the main portion of the muscle, arises from a narrow tendinous band, the anococcygeal raphe, which stretches from the tip of the coccyx to the posterior margin of the anus; it forms two flattened planes of muscular tissue, which encircle the anus and meet in front to be inserted into the central tendinous point of the perineum, joining with the superficial transverse perineal muscle, the levator ani, and the bulbospongiosus muscle also known as the bulbocavernosus. The deeper portion forms a complete sphincter to the anal canal. Its ...

Detection of high-grade squamous intraepithelial lesions (HSILs) on an anal Pap smear had a sensitivity of 47% (95% CI, 35%59%) and specificity of 90% (95% CI, 81%96%) for detection of a high-grade histological finding (AIN level 2, AIN level 3, or SCC) in the paired specimen. Likewise, detection of low-grade squamous intraepithelial lesions (LSILs) on an anal Pap smear had a sensitivity of 68% (95% CI, 56%78%) and a specificity of 48% (95% CI, 36%59%) for detection of AIN level 1 by the paired examination. A Pap smear finding of atypical squamous cells of uncertain significance showed essentially an equal distribution of pathological grades on paired histological examinations. The positive and negative predictive values were 81% (95% CI, 66%92%) and 65% (95% CI, 55%74%), respectively, for HSIL on Pap smears predicting high-grade histological findings (P < .01). The positive and negative predictive values for LSIL were 59% (95% CI, 48%69%) and 57% (95% CI, 44%70%), respectively, for prediction ...

Intractable ulcerating enterocolitis is an uncommon inflammatory bowel disease syndrome of neonatal onset first described in 1991. Intractable ulcerating enterocolitis usually presents in the neonate with a mouth ulceration and the subsequent development of perianal disease and colitis.. In this case report, an infant, 18 days from birth, with ulcerative lesion on hard palate for systemic differential diagnosis about oral lesion is referred from the department depiatrics. At that time, there is no abnormality, except oral lesion-like Aphthous ulcer. The patient was discharged from pediatrics, but returned to the hospital 3weeks later with blood diarrhea. As a result of endoscopy, there were large ulcerating lesions and the patient was diagnosed intractable ulcerating enterocolitis.. Early recognition of Intractable ulcerating enterocolitis appears to be beneficial because colectomy, as opposed to immunosuppression, appears to be effective in controlling disease symptoms and progression. Most of ...

Results Sixty-one papers (35 costs; 24 utilities; 2 costs and utilities) were selected from 10 742 initial records. Cost per case ranges were US$124-US$883 (anogenital warts), US$6912-US$52 579 (head and neck cancers), US$12 936-US$51 571 (anal cancer), US$17 524-34 258 (vaginal cancer), US$14 686-US$28 502 (vulvar cancer) and US$9975-US$27 629 (penile cancer). The total cost for 14 adult patients with recurrent respiratory papillomatosis was US$137 601 (one paper).. Utility per warts episode ranged from 0.651 to 1 (12 papers, various utility elicitation methods), with pooled mean EQ-5D and EQ-VAS of 0.86 (95% CI 0.85 to 0.87) and 0.74 (95% CI 0.74 to 0.75), respectively. Fifteen papers reported utilities in head and neck cancers with range 0.29 (95% CI 0.0 to 0.76) to 0.94 (95% CI 0.3 to 1.0). Mean utility reported ranged from 0.5 (95% CI 0.4 to 0.61) to 0.65 (95% CI 0.45 to 0.75) (anal cancer), 0.59 (95% CI 0.54 to 0.64) (vaginal cancer), 0.65 (95% CI 0.60 to 0.70) (vulvar cancer) and 0.79 ...

Conditions: HPV - Anogenital Human Papilloma Virus Infection; HSIL, High Grade Squamous Intraepithelial Lesions; Anal Cancer; ...

The abdominoperineal resection of the rectum is a classical operation performed in case of patients diagnosed with rectal cancer. The development of laparoscopic techniques in recent years, introduced yet another method of treatment, considering patients with rectal cancer- laparoscopic abdominoperineal resection of the rectum. The aim of the study was to present initial treatment results considering the above-mentioned patients. Material and methods. The study group comprised 25 patients (16 male and 9 female) diagnosed with low-rectal cancer, subjected to surgery by means of the above-mentioned method. Mean patient age amounted to 66 years. Three (12%) patients required conversion to classical surgery (laparotomy), while one patient required reoperation, due to presacral vascular bleeding. Complications were observed in 10 (40%) patients. Average hospitalization was 7 days. In case of all patients the radial margin was negative, and mean number of removed lymph nodes amounted to 9.6. Mortality ...

Poynten IM; Tabrizi SN; Jin F; Templeton DJ; Machalek DA; Cornall A; Phillips S; Fairley CK; Garland SM; Law C, 2017, 'Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men', Papillomavirus Research, vol. 3, pp. 80 - 84, http://dx.doi.org/10.1016/j.pvr.2017.02.003. Molano M; Tabrizi SN; Garland SM; Roberts JM; MacHalek DA; Phillips S; Chandler D; Hillman RJ; Grulich AE; Jin F, 2016, 'CpG methylation analysis of hpv16 in laser capture microdissected archival tissue and whole tissue sections from high grade anal squamous intraepithelial lesions: A potential disease biomarker', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0160673. Hillman RJ; Cuming T; Darragh T; Nathan M; Berry-Lawthorn M; Goldstone S; Law C; Palefsky J; Barroso LF; Stier EA, 2016, '2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors', Journal of Lower Genital Tract Disease, vol. 20, pp. 283 - 291, ...