In multicellular organisms, compartments with different compositions are separated by epithelia. Exchange of solutes between compartments can occur through (transcellular) or around (paracellular) the epithelial cells. Tight junctions between the cells form an ion-selective barrier across the paracellular route, and several human diseases involve a breakdown of these junctions. On p. 5109, Daniel Goodenough and colleagues report that the tight junction protein paracellin 1 (claudin-16) can modulate tight junction ion selectivity in the renal epithelial cell line LLC-PK1, which does not normally express this protein. When the authors express paracellin 1 in these cells, it localizes to the tight junctions and increases their permeability to Na+ but not to Cl- or Mg2+. Mutagenesis studies indicated that the extracellular loops of paracellin 1 are critical for this ion selectivity. Similar paracellin 1 mutations cause human familial hypomagnesemia with hypocalcinuria and nephrocalcinosis (FHHNC), ...

The introduction of transporter transfected cell lines capable of forming tight cell layers has facilitated the investigation of single transporter interactions on monolayers. Epithelial-like pig kidney cell line (LLC-PK1) forms a tight monolayer on suitable transwell inserts and separates the two fluid compartments above and below it. Transporters present in the cell membrane can have crucial influence on material traffic between the two compartments. The difference between efflux ratios of the transfected and parental cell lines is regarded as a sign of transporter mediated active uptake or efflux process.. SOLVOs single transfectant LLC-PK1 cell lines (BCRP) are excellent tools to investigate specific transporter interactions for medium to high permeability test articles. These service assays are offered in two modes, inhibitor and substrate assessment. (In the inhibitor assessment experiments the effect of the test articles on the transport of the reporter substrate is measured).. ...

Two low-molecular-mass Ni-binding fractions first isolated from human kidneys [Templeton & Sarkar (1985) Biochem. J. 230, 35-42] are further characterized. Both components are acidic and are readily separated from each other by gel chromatography on Bio-Gel P-2. After equilibration with 63Ni the largest complex constitutes about 30% of the radioactive 63Ni and is an approx. 3.5 kDa peptide and the smallest species comprise short oligosaccharides containing 70% of the radioactivity. Both of these components are found in human, bovine and porcine kidneys as well as in a porcine proximal tubule-like cell line LLC-PK1. There is a small variation in amino acid composition between species. The oligosaccharides are reducing sugars and contain sulphate, glucosamine, glucuronic acid and iduronic acid with two to four overall negative charges. The monosaccharide composition was determined by h.p.l.c. with pulsed amperometric detection of the acid hydrolysates and by gas chromatography. In the LLC-PK1 cell ...

The present study was performed to elucidate whether SeCys-conjugates are able to protect renal tubular cells (LLC-PK1 cells) against cisplatin-induced cytotoxicity. In addition to the wild-type LLC-PK1 cell line, cells stably expressing rat kidney β-lyase/GTK (R1J cells) were used. The latter cells were constructed by Goldfarb et al. (1996) by transfection of full-length cDNA coding for rat β-lyase/GTK (Perry et al., 1993) into the LLC-PK1 cell line. Expression of immunoreactive β-lyase/GTK in R1J cells was confirmed by Western blotting. In agreement with this, the R1J cells showed an 8- to 12-fold higher β-lyase activity compared with the LLC-PK1cells, depending on the substrate used. A similar effect was reported previously by Goldfarb et al. (1996) usingS-(1,2-dichlorovinyl)-l-cysteine as a substrate, although the β-lyase activity in R1J cells was up to 100-fold that of the parental cell line. As shown in the present study, the R1J cells showed a 3-fold higher sensitivity toward the ...

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In cultured intact LLC-PK1 renal epithelial cells, a nonhydrolyzable ATP analogue, ATP gamma S, inhibits AVP-stimulated cAMP formation. In LLC-PK1 membranes, several ATP analogues inhibit basal, GTP-, forskolin-, and AVP-stimulated adenylate cyclase activity in a dose-dependent manner. The rank order potency of inhibition by ATP analogues suggests that a P2y type of ATP receptor is involved in this inhibition. The compound ATP gamma S inhibits agonist-stimulated adenylate cyclase activity in solubilized and in isobutylmethylxanthine (IBMX) and quinacrine pretreated membranes, suggesting that ATP gamma S inhibition occurs independent of AVP and A1 adenosine receptors and of phospholipase A2 activity. The ATP gamma S inhibition of AVP-stimulated adenylate cyclase activity is not affected by pertussis toxin but is attenuated by GDP beta S, suggesting a possible role for a pertussis toxin insensitive G protein in the inhibition. Exposure of intact LLC-PK cells to ATP gamma S results in a significant ...

Background/Aims: We have previously reported that ischemia/reperfusion injury (IRI) to the kidney leads to induced expression of RACK1 and changes in the level of expression and subcellular distribution of PKC isozymes α, βII and ζ. In order to further define the role of PKC isozymes in IRI we investigated the effect of activation or inhibition of the isozymes on cytotoxicity mediated by H|sub|2|/sub|O|sub|2|/sub| in LLCPK|sub|1|/sub| cells. Methods: Cytotoxicity was analyzed by Trypan blue assay and LDH release assay. Translocation of PKC isozymes postinjury in LLCPK1 cells was analyzed by immunostaining and Western blot analysis. Results: Western blot analysis showed that the expression of PKC-α was up-regulated in a triphasic pattern with the initial induction within the first 10 min of injury followed by higher levels of expression at 2 and 24 h postinjury. The expression of PKC-ζ was highly induced within the first 15 min of injury but its expression was down-regulated to that of normal

BioAssay record AID 1077516 submitted by ChEMBL: Selectivity index, ratio of IC50 for pig LLC-PK1 cells to IC50 for Plasmodium falciparum W2.

Although the cellular response to chemical-induced stress is relatively well characterized, particularly the response to DNA damage, factors that govern the outcome of the stress response (cell survival or cell death) are less clearly defined. In this context, the mitogen-activated protein kinase (MAPK) family responds to a variety of physical and chemical stresses. The activation of MAPKs, especially the extracellular-regulated protein kinase subfamily, seems to play a causal role in death of renal proximal tubular epithelial cells (LLC-PK1) induced by reactive oxygen species (ROS). In this study, we show that extracellular signal receptor-activated kinase (ERK) activation may be coupled with LLC-PK1 cell death via changes in chromatin structure, which is mediated by increases in the phosphorylation of histone H3 (a post-translational modification required for both chromosome condensation and segregation during mitosis) and premature chromatin/chromosomal condensation, leading to cell death. In ...

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The effects of aminoglycoside antibiotics on cellular functions of the LLC-PK1 kidney epithelial cell line were studied as a model system for aminoglycoside nephrotoxicity. The treatment with aminoglycoside antibiotics for 3 days caused a decrease in the dome number in the confluent LLC-PK1 cells and an increase in the floating cells in the culture medium. The inhibition of dome formation was dose-dependent and the rank-order of the degree of inhibition was compatible with the rank-order of in vivo nephrotoxicity. Aminoglycosides also decreased the intracellular content of cyclic AMP, with a correlation between the alteration of dome formation and cyclic AMP content. The specific activities of N-acetyl-beta-D-glucosaminidase (marker for lysosomes), aminopeptidase and alkaline phosphatase (marker for apical membranes) and (Na++K+)-adenosine triphosphatase (marker for basolateral membranes) in the homogenate were decreased by gentamicin treatment. Lysosomal and apical membrane enzymes released ...

4894 NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys PubMed US National Library of Medicine National Institutes of Health Search databaseSearch termSearch AdvancedHelp Result Filters Format: AbstractSend to Pharm Res. 1996 Jul;13(7):1073-7. Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. Tanaka K1, Hirai M, Tanigawara Y, Yasuhara M, Hori R, Ueda K, Inui K. Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. Pharm Res 1996 13(7):1073-7 PubMed ID: 8842048 ...

time of taking tasigna - posted in Chronic Myeloid Leukemia: Hi, this starts my 8th week taking tasigna, so far so good, i think. i was just wondering about the hour of day most people take tasigna? i was taking it at 9am & 9pm. but the eating early now that spring is here, {yeah right, calling for another snow thurdsday, yuck!] i started taking it at 4am & 4pm. that way i can eat later and feel more satisfied in the evening. also, my onc has my blood work done every 2 weeks inste...

Tasigna (nilotinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Tasigna is used to treat a type of blood

In this study, we provide the first evidence that Na,K-ATPase is a target of TGF-β1 signaling during the induction of EMT. We show that following the treatment of renal proximal tubule cells with TGF-β1, NaK-β1 surface expression is reduced before well-characterized EMT markers, such as E-cadherin, and the induction of fibronectin and α-SMA. We validated the significance of NaK-β1 in the induction of EMT by two complementary approaches. RNAi-mediated specific knockdown of NaK-β1 resulted in the loss of the epithelial phenotype, whereas the ectopic expression of NaK-β1 delayed the induction of a fibroblastic phenotype and reduced the levels of fibronectin and α-SMA following TGF-β1 treatment. We further show that NaK-β1 reduction is a common event in EMT irrespective of the type of EMT.. RNAi-mediated specific knockdown of NaK-β1 is sufficient to induce a fibroblastic phenotype of LLC-PK1 cells. We have shown earlier that NaK-β1 expression is reduced in a wide variety of poorly ...

Profile of SCAI (SCAI technologies and role in projects such as @neurIST) and perception about VPH and the necessary balance between biology and medicine; IT infrastructure and mathematical / algorithmic modeling ...

Day 1. Cell growth. MCF7, LLC-PK1 cells. Grow MCF7 or LLC-PK1 cells at 37˚C in high glucose DMEM, supplemented with 8% FBS, sodium pyruvate and antibiotics [15, 16]. 24 hours prior to the experiment, trypsinize cells and culture overnight on glass cover slips coated with poly-L-lysine.. Superior cervical ganglion (SCG) neurons. Prepare SCG neurons from postnatal day 1 to 7 as described [11]. Culture cells on glass coverslips (coated with laminin) in modified 35 mm dishes (Corning) at 37˚C for 7-10 days; change medium twice per week.. Day 2. Treatment with MitoTracker®. Remove medium and treat cells with fresh DMEM supplemented with MitoTracker® (diluted 1:5,000 in DMEM). Incubate for 30 minutes at 37˚C in a cell culture incubator (5% CO2).. Fixation, permeabilization, block of non-specific binding sites * MCF7 and LLC-PK1 cells*. After 30 min incubation with MitoTracker®, remove the tissue culture medium, wash cells once with pre-warmed PBS. Fix samples in 3.7 % formaldehyde/PBS for 15 min ...

The transcellular transport of many compounds, which cannot readily cross the lipid bilayer, is mediated by drug uptake and efflux transporters. Human OATP1B1 and MRP2 have been implicated in the hepato-biliary transport of many endogenous and exogenous compounds. Here, we have established epithelia …

The transport of S-cysteine conjugates was studied in the kidney cell line, LLC-PK1, using the nephrotoxin, S-(1,2-dichlorovinyl)-L-cysteine (L-DCVC), as the model compound. The saturable uptake of this conjugate did not require sodium and was selectively inhibited by the amino acid transport system L-specific substrate, 2-amino-2-norbornane carboxylic acid, as well as a variety of other S-cysteine conjugates and neutral amino acids with large, nonpolar side chains. Kinetic studies suggested the existence of both low and high affinity transport systems with Km values that differed by 25-fold. Although these uptake systems showed no discernible differences in substrate specificity, the low affinity transport was more sensitive to trans-stimulation. L-DCVC uptake in subconfluent cultures was about 3-fold that of confluent cells, suggesting either adaptive regulation to cell growth or polarization of transport to the basolateral membrane. L-DCVC toxicity in LLC-PK1 cells was inhibited in the ...

Tubulogenesis in epithelial organs often initiates with the acquisition of apicobasal polarity, giving rise to the formation of small lumens that expand and fuse to generate a single opened cavity. In this study, we present a micropattern-based device engineered to generate epithelial tubes through a process that recapitulates in vivo tubule morphogenesis. Interestingly, tubulogenesis in this device is dependent on microenvironmental cues such as cell confinement, extracellular matrix composition, and substrate stiffness, and our set-up specifically allows the control of these extracellular conditions. Additionally, proximal tubule cell lines growing on micropatterns express higher levels of drug transporters and are more sensitive to nephrotoxicity. These tubes display specific morphological defects that can be linked to nephrotoxicity, which would be helpful to predict potential toxicity when developing new compounds. This device, with the ability to recapitulate tube formation in vitro, has ...

The purpose of this study was to establish whether curcumin protects renal proximal tubule cells against ischemic injury, determine whether this postulated cytoprotective effect is mediated through the upregulation of HSP70, and investigate whether the mechanism by which curcumin induces HSP70 expression and confers its protective effect is through activation of the Unfolded Protein Response. LLC-PK1 cells were cultured on collagen-coated filters to mimic conditions of in vivo renal proximal tubule cells and induce cell polarization. Injury with and without curcumin treatment was studied by using chemically-induced ATP-depletion which mimics renal ischemic injury. Cell injury was assessed using a TUNEL assay in order to evaluate DNA cleavage associated with ischemia-induced apoptosis and actin staining used to assess cytoskeletal disruption. Renal ischemic damage was further investigated by determining detachment of the Na-K ATPase from the basolateral membrane, which represents loss of cell polarity.

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Apigenin protects renal tubular epithelial cells against high glucose-induced injury through suppression of oxidative stress and inflammation.

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Probably should be fixed in formaldehyde, since the glutaraldehyde in paraglut interferes with the anti-Golgi staining. LLCPK - at least 2 per group Should be already in the refrigerator from pre-semester prep, in coplin jars of PBS-Tw-Az. ...

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Researchers have discovered and outlined a way to create generations of stem cells using just your mellow yellow. Breakthrough after breakthrough has been made regarding stem cells, and this is […] ...

Copyright © 2020 American Chemical Society. The ability to monitor the status and progression of viral infections is important for development and screening of new antiviral drugs. Previous research illustrated that the osmolyte glycine (Gly) reduced porcine parvovirus (PPV) infection in porcine kidney (PK-13) cells by stabilizing the capsid protein and preventing virus capsid assembly into viable virus particles. Dielectrophoresis (DEP) was examined herein as a noninvasive, electric field- and frequency-dependent tool for real-time monitoring of PK-13 cell responses to obtain information about membrane barrier functionality and polarization. DEP responses of PK-13 cells were compared to those of PPV-infected cells in the absence and presence of the osmolyte glycine. With infection progression, PK-13 DEP spectra shifted toward lower frequencies, reducing crossover frequencies (fCO). The spherical single-shell model was used to extract PK-13 cell dielectric properties. Upon PPV infection, specific

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Departments of Mechanistic Safety and Disposition (H.L., T.F., X.S.), Bioanalysis, Immunogenicity and Biomarker (L.H., R.G., K.D.), Protein, Cellular and Structural Sciences (Q.C.), Modeling and Computational Sciences (Y.-Y.Z.), Integrated Biological Platform Sciences (W.Z.), and Drug Metabolism and Pharmacokinetics (Y.L., J.S.), Platform Technology and Science, GlaxoSmithKline R&D China; and Department of Bioanalysis, Immunogenicity and Biomarker (S.S.), Platform Technology and Science, GlaxoSmithKline, Ware, United Kingdom ...

ATCC hTERT immortalized renal epithelial cells have an extended lifespan, show phenotypic characteristics of angiomyolipomas, and are karyotypically, morphologically, and phenotypically similar to the primary parent cells.

ATCC hTERT immortalized renal epithelial cells have an extended lifespan, show phenotypic characteristics of angiomyolipomas, and are karyotypically, morphologically, and phenotypically similar to the primary parent cells.

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Fraunhofer Institute for Algorithms and Scientific Computing SCAI - Master Theses. Online in Internet; URL: https://www.scai.fraunhofer.de/en/media-center/publications/academic-theses/master-theses.html. Date: 12.5.2021 18:46. ...

TY - JOUR. T1 - Morphogenetic clonal growth of kidney epithelial cell line MDCK. AU - McAteer, James A.. AU - Evan, Andrew P.. AU - Gardner, Kenneth D.. PY - 1987/3. Y1 - 1987/3. N2 - MDCK (Madin-Darby canine kidney) cells were cultured either 1) dispersed within hydrated collagen gel (HCG) or 2) seeded atop a collagen substrate and then immediately overlaid with HCG. Individual cells exhibited clonal growth in three dimensions to form spherical cysts made up of a simple epithelium enclosing a fluid-filled lumen. The cells of MDCK cysts were polarized with the basolateral surface in contact with the collagen gel and the apical surface bordering the lumen. The ultrastructure of MDCK cysts showed similarities to distal nephron. The cells bore apical microvilli and solitary cilia and had occluding junctions and a simple basolateral surface. MDCK cysts increased in size (, 800 μm diameter) with continued culture. MDCK cysts grown between layers of HCG were stripped free of the overlying collagen to ...

TY - JOUR. T1 - Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. AU - Pabla, Navjotsingh. AU - Dong, Guie. AU - Jiang, Man. AU - Huang, Shuang. AU - Kumar, M. Vijay. AU - Messing, Robert O.. AU - Dong, Zheng. PY - 2011/7. Y1 - 2011/7. N2 - Cisplatin is a widely used cancer therapy drug that unfortunately has major side effects in normal tissues, notably nephrotoxicity in kidneys. Despite intensive research, the mechanism of cisplatin-induced nephrotoxicity remains unclear, and renoprotective approaches during cisplatin-based chemotherapy are lacking. Here we have identified PKCδ as a critical regulator of cisplatin nephrotoxicity, which can be effectively targeted for reno-protection during chemotherapy. We showed that early during cisplatin nephrotoxicity, Src interacted with, phosphorylated, and activated PKCδ in mouse kidney lysates. After activation, PKCδ regulated MAPKs, but not p53, to induce renal cell ...

TY - JOUR. T1 - IL-10 from dendritic cells but not from T regulatory cells protects against cisplatin-induced nephrotoxicity. AU - Wang, Wei Wei. AU - Wang, Yamei. AU - Li, Kang. AU - Tadagavadi, Raghu. AU - Friedrichs, William E.. AU - Budatha, Madhusudhan. AU - Reeves, W. Brian. N1 - Funding Information: This work was supported in part by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK-081876 and DK-108185) to W.B.R. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.. PY - 2020/9. Y1 - 2020/9. N2 - Interleukin-10 (IL-10), a cytokine with anti-inflammatory effects, is produced by renal parenchymal cells and bone marrow derived cells. Both endogenous and exogenous IL-10 are protective in cisplatin-induced acute kidney injury. However, the source of endogenous IL-10 in cisplatin-induced nephrotoxicity is not clear. Bone ...

Tasigna® (nilotinib) is a cancer medication manufactured by Novartis that was approved in the U.S. in 2007 for the treatment of Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML).. In April 2013, the prescribing information for Tasigna was updated in Canada after health officials warned that 277 cases of atherosclerosis had been reported worldwide between January 2005 and January 2013.. Atherosclerosis is a life-threatening artery disease that can cause narrowing of the blood vessels that carry oxygen-rich blood to the body. It is a risk-factor for blood clots, heart attack, stroke, and death.. Canadian health experts recommended that patients on Tasigna should be closely monitored for signs of arterial disease, but these warnings never trickled down to doctors in the U.S. or their patients.. In March 2016, the family of a man from California who died of atherosclerosis complications after taking Tasigna filed a lawsuit accusing Novartis of failing to warn patients in the U.S. ...

Tasigna is a cancer drug indicated to treat patients suffering from Philadelphia chromosome positive chronic myelogenous leukemia (CML).. At least a dozen studies published in prominent medical journals have suggested a link between Tasigna and arteriosclerosis. In April 2013, the Canadian prescribing information for Tasigna was updated to note a potential risk of arteriosclerosis. An alert issued by Health Canada noted a review of the Novartis global safety database had identified of 277 cases of atherosclerosis reported between January 1, 2005 and January 31, 2017.. While information about arteriosclerosis was added to the Tasignas U.S. label, a public notification was never issued to doctors and patients in this country. ...

TY - JOUR. T1 - Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity. AU - Ridzuan, Nurul Raudzah Adib. AU - Rashid, Norhashima Abd. AU - Othman, Faizah. AU - Budin, Siti Balkis. AU - Pa Pa Hlaing @ Farida Hussan, Khin. AU - Teoh, Seong Lin. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Cisplatin is a widely used antineoplastic agent for the treatment of metastatic tumors, advanced bladder cancer and many other solid tumors. However, at higher doses, toxicities such as nephrotoxicity may appear. Cisplatin leads to DNA damage and subsequently renal cell death. Besides that, oxidative stress is also implicated as one of the main causes of nephrotoxicity. Several studies showed that numerous natural products: ginseng, curcumin, licorice, honey and pomegranate were able to reduce the oxidative stress by restoring the levels of antioxidant enzymes and also at the same time act as an anti-inflammatory agent. Furthermore, pre-treatment with vitamin supplementation, such as vitamin C, E and ...

2021 MSCAI Recipients Recognized during the SCAI 2021 Scientific Sessions Virtual Conference WASHINGTON, May 3, 2021 - The Society for Cardiovascular Angiography and Interventions (SCAI) presented its Master Interventionalists of SCAI (MSCAI) designations during the SCAI 2020 Scientific Sessions Virtual Conference MSCAI recognition ceremony.

The challenge? Advances in peripheral interventions are moving at the speed of light, and the number of complex PVD patients is rapidly growing. However, present guidelines and data do not adequately inform thoughtful clinicians how to provide the best care for their patients. The solution? SCAI has developed the Complex Peripheral Vascular Interventions Workshop (SCAI CPVI) to help you incorporate state-of-the-art peripheral interventions into your real-world practice using a novel, interactive education approach focused on how you learn best. Taking place Sept. 25-26 in Washington, D.C., this course is designed to ensure one-on-one interaction with faculty and fellow attendees. Best yet? SCAI is helping you extend your educational budget by offering low tuition starting at just $229 if you register by Friday ...

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two novartis phase iii studies show twice as many ph+ cml patients achieve deeper levels of response with tasigna ae compared to gleevec ae

TY - JOUR. T1 - Prophylactic effect of diacerein against cisplatin-induced nephrotoxicity in rats. AU - Abdel-Aziz, Asmaa Mohamed. AU - Ibrahim, Mohamed Abdellah. AU - El-Shiekh, Azza Ali. AU - Osman, Nisreen Abdel Tawab. AU - Geddawy, Ayman. AU - Abdelrahman, Aly. PY - 2018. Y1 - 2018. N2 - Background and Objective: Cisplatin is an effective chemotherapeutic agent for solid tumors, however its use is limited by nephrotoxicity. The current study investigated the effect of diacerein in cisplatin-induced nephrotoxicity in rats. Materials and Methods: Rats were randomly divided into 5 groups; control (untreated), diacerein control (100 mg kgG1), cisplatin (5 mg kgG1 i.p.), cisplatin+diacerein (50 mg kgG1) and cisplatin+diacerein (100 mg kgG1). Data were analyzed by one way ANOVA using GraphPad Prism. Results: Administration of cisplatin caused significant deterioration in renal function, designated by the increase in serum levels of both urea and creatinine, reduction in creatinine clearance, ...

TY - JOUR. T1 - Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein. AU - Kusunoki, Nobuya. AU - Takara, Kohji. AU - Tanigawara, Yusuke. AU - Yamauchi, Aiko. AU - Ueda, Kazumitsu. AU - Komada, Fusao. AU - Ku, Yonson. AU - Kuroda, Yoshikazu. AU - Saitoh, Yohichi. AU - Okumura, Katsuhiko. PY - 1998. Y1 - 1998. N2 - The inhibitory effects of SDZ PSC 833 (PSC833), a non-immunosuppressive cyclosporin derivative, on the P-glycoprotein (P-gp)-mediated transport of doxorubicin and vinblastine were compared with those of cyclosporin A (Cs-A). The transcellular transport of the anticancer drugs and PSC833 across a monolayer of LLC-GA5-COL150 cells, which overexpress human P-gp, was measured. Both PSC833 and Cs-A inhibited P-gp-mediated transport of doxorubicin and vinblastine in a concentration-dependent manner and increased the intracellular accumulation of doxorubicin and vinblastine in LLC-GA5-COL150 cells. The values of the ...

Croft, Wayne D., Hills, Claire E., McCann, Eilish Clare, Bond, Michael, Esparza-Franco, Manuel A. , Bennett, Jeanette, Rand, D. A. (David A.), Davey, John and Ladds, Graham. (2013) A physiologically required G protein-coupled receptor (GPCR)-regulator of G protein signaling (RGS) interaction that compartmentalizes RGS activity. Journal of Biological Chemistry, Volume 288 (Number 38). pp. 27327-27342. ISSN 0021-9258 Bland, Rosemary, Zehnder, Daniel, Bennett, Jeanette, Markovic, Danijela and Hewison, Martin. (2012) Calcium sensing receptor-mediated regulation of vitamin D metabolism in a human proximal tubule cell line. Bone, Vol.51 (No.6). Article no.S29. ISSN 8756-3282 Hills, Claire E., Younis, Mustafa Y. G., Bennett, Jeanette, Siamantouras, Eleftherios, Liu, Kuo-Kang and Squires, Paul E.. (2012) Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function. Cellular Physiology and Biochemistry, Vol.30 (No.3). pp. 575-586. ISSN 1015-8987 Hills, Claire E., Bland, Rosemary, ...

Services include evaluation of drug-transporter interactions using in vitro models expressing human and animal transporters from the ABC-binding cassette (ABC) and solute-linked carrier (SLC) superfamilies. We also offer the unique capability to study human P-gp-mediated drug transport using the cDNA transfected LLCPK 1 porcine cell line. For SLC transport studies, we use TransportoCells to assess if your test article is a substrate and/or inhibitor of uptake transporters in line with the latest regulatory guidance for develop-ment of new investigational drugs.. ...

Dissertation, Eberhard Karls Universität Tübingen, 2016; Erscheint auch als, Online-Ausgabe, Braun, Norbert, UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma, Tübingen, 2017, 1 Online-Ressource (65 Seiten), ...

Principal Investigator：IWAMOTO Takahiro, Project Period (FY)：2011 - 2013, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：General pharmacology

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