Because of the interest in the relationship between cholesteryl ester (CE) accumulation and atherosclerosis, we have attempted to select an easily grown tissue culture cell which accumulates CE when...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent hepatocarcinogen in rodents. However, liver tumor incidence is increased by TCDD in female Sprague-Dawley rats but not male rats in chronic carcinogen bioassays. Our studies have investigated this finding by evaluating histological and biochemical parameters in a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats (intact and ovariectomized), using diethylnitrosamine (DEN) as the initiating agent and TCDD as the promoting agent. Increases in γ-glutamyl transpeptidase-positive foci were greater in intact female rats than in ovariectomized (OVX) animals. For example, in intact rats receiving both DEN and TCDD, the percentage of liver occupied by γ-glutamyl transpeptidase-positive foci was 0.37, compared to 0.08 in OVX rats. Values for intact or OVX rats receiving either DEN or TCDD only were 0.04 or less. Similar results were obtained when using placental glutathione S-transferase to detect hepatic preneoplastic lesions. ...
Abstract. Background: To investigate the efficacy of TACE combined with CQ, an autophagic inhibitor, in a rabbit VX2 liver tumor model.. Methods: Tumor size was measured. And tumor growth rate was calculated to examine the effect of the combined treatment. Apoptosis was detected by TUNEL assay. Meanwhile, autophagic activity was detected by immunohistochemistry and Western blotting to investigate the mechanism underlying. Liver function was also examined to assess feasibility and safety of the combined therapy.. Results: Tumors in the control grew more than 4 times bigger after 14 days, while that in the group of TACE alone just showed mild growth. But a slight shrinkage was shown after the treatment of CQ+TACE. Growth ratio of TACE alone was 96.45% ± 28.958% while that of CQ+TACE was -28.73% ± 12.265%. Compared with TACE alone, necrosis in CQ+TACE showed no significant difference, however, the apoptosis was much higher. There were only 14.8±3.11% apoptotic cells in TACE, but 33±4.18% in ...
10 Apr 2017. Liver cancers are a major cause of cancer-related deaths.. Large-scale genetic analyses have associated liver cancer with dysregulation of numerous molecular pathways, but disruptions in insulin signalling pathways appear to have a particularly important contribution to liver tumour formation.. Obesity is a major risk factor for developing liver cancer, and the nuclear receptor PPARγ critically controls fat uptake and storage in the liver by regulating the transcription of metabolism-associated genes.. However, whether PPARγ also plays a role in promoting the growth of liver tumours is not clear.. This week in the JCI, research led by Ganna Panasyuk at INSERM examined the link between PPARγ and liver tumour formation.. The findings identify a metabolic pathway with pro-tumour effects that can be suppressed by selectively blocking PPARγ.. Researchers initially observed that increases in PPARγ expression and activity in human liver tumours were associated with loss-of-function of ...
Phosphodiesterase 3B (PDE3B) is an important component of insulin and cAMP-dependent signalling pathways. In order to study phosphorylation of PDE3B, we have used an adenoviral system to express recombinant flag-tagged PDE3B in primary rat adipocytes and H4IIE hepatoma cells. Phosphorylation of PDE3B after treatment of cells with insulin, cAMP-increasing agents, or the phosphatase inhibitor, calyculin A was analyzed by two-dimensional tryptic phosphopeptide mapping and mass spectrometry. We found that PDE3B is multisite phosphorylated in adipocytes and H4IIE hepatoma cells in response to all these stimuli. Several sites were identified; serine (S)273, S296, S421, S424/5, S474 and S536 were phosphorylated in adipocyte as well as H4IIE hepatoma cells whereas S277 and S507 were phosphorylated in hepatoma cells only. Several of the sites were phosphorylated by insulin as well as cAMP-increasing hormones indicating integration of the two signalling pathways upstream of PDE3B, maybe at the level of ...
Polysome and ribosome preparations from normal rat liver and from a series of transplantable rat hepatomas of different growth rates were compared. All the hepatomas had a significantly higher percentage of RNA in a polysome preparation than did the normal liver, and the polysome preparations from the tumors, with the exception of the Dunning hepatoma which has a high lipid content, gave a greater yield of RNA and protein per gram of wet tissue than the liver did. Heavier polysomes were considerably less prevalent in the tumors than in the liver, and the tumors contained a larger proportion of monomer and dimer ribosomes than the liver did. Evidence is presented that the increased monomer and dimer ribosome population of the hepatomas studied is not an artifact of preparation, but represents the true intracellular distribution. Ribosomes from normal liver and Morris 5123-D hepatoma were readily dissociated by 20 min treatment with 1.0 mM EDTA, but ribosomes from the Dunning, Novikoff ascites, ...
Biochemical and molecular biological approaches in situ have provided compelling evidence for early bioenergetic changes in hepatocarcinogenesis. Hepatocellular neoplasms regularly develop from preneoplastic foci of altered hepatocytes, irrespective of whether they are caused by chemicals, radiation …
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation ...
Phosphatidylcholine, phosphatidylethanolamine, and triglycerides were isolated from minimal deviation hepatoma 7288C cells cultured as monolayers to confluency in roller flasks containing Swims 77...
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Results: HQG treatment inhibited hepatoma growth in tumour-bearing mice. Cell apoptosis rate of human hepatoma 7402 cells and of the cells from ascites in tumour-bearing mice was increased after HQG treatment. Mitochondrial membrane potential in human hepatoma 7402 cells was decreased after HQG treatment. CD4+ and CD8+ T- lymphocytes subpopulation was increased while the ratio of CD4+/ CD8+ decreased in tumour-bearing mice after HQG administration. IFN-γ and IL-4 secretion was increased in spleen lymphocytes in tumour-bearing mice after HQG administration ...
Sauvage, P. ; Lopezsaura, P. ; Leroyhouyet, MA. ; Tulkens, Paul M. ; Trouet, André. Analytical Characterization and Purification of Plasma-membrane From Cultured Hepatoma-cells (htc Cells). In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 644, no. 1, p. 41-52 (1981 ...
Reuber, M, "Morphologic and biologic correlation of hyperplastic and neoplastic hepatic lesions occurring spontaneously in c3h x y hybrid mice." (1971). Subject Strain Bibliography 1971. 1817 ...
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体态优美!《甲铁城》无名高质量手办开放预售《甲铁城的卡巴内利》作为春季热门番,女主角无名在御宅族更是人气火热,许多手办商也纷纷将无名手办化。近日知名高质量手办制造商GOOD SMILE COMPANY也宣布发售一款无名手办,将于明天(10月25日)开始预售。这款无名手办身穿战斗服,身上背着机械武器,这些武器都是可动设计。虽然身上的装备看起来很重,但无名的动作却看起来分外轻盈。一只脚踩在架子上,另一条腿抬起的动作看起来分外有跃动感,而细节处的侧乳和腋下也非常性感,而裙底的秘密就要等大家购买后才知道了!无名的脸部也非常可爱,十分还原原作画风,下面就让我们来欣赏一组手办的细节吧!这款无名手办为1 ...
03. 儿子为了哄老人开心,便一直穿女装,没想到一穿竟整整二十年。由于男人穿女装一直被视为变态行为,因此这位男子也就一直没有找到女朋友,工作也丢了,但是男子表示只要能让母亲开心,自己委屈一点没什么。目前这名男子靠卖唱、吹笛子养活老人和自己。. 古有花木兰,扮男替父从军. 今有桂林男儿,扮女哄母. 在微博上很多人被这个孝子暖哭了. 纷纷为这位男子的行为点赞!. ...
포화 지방의 섭취를 줄이거나 제한하기 위한 권장사항들은 세계보건기구,[71] 미국 심장 협회,[6] 캐나다 보건부,[72] 미국 보건복지부,[73] 영국 국민 건강 서비스,[74] 오스트레일리아 연방 보건복지부,[75] 싱가포르 건강촉진국,[76] 인도 정부 시민건강포털,[77] 뉴질랜드 보건부,[78] 홍콩 식품안전청[79] 등에 의해 만들어졌다. 2003년에 세계보건기구(WHO)와 식량농업기구(FAO)의 전문가 협의 보고서는 포화 지방산의 섭취는 심혈관계 질환의 위험과 직접 관련이 있다고 결론을 내렸다.[80] 기존의 목표는 포화 지방산의 섭취를 일일 에너지 섭취량의 10% 미만, 고위험군의 경우 7% 미만으로 제한하는 것이다. 만약 10% 미만을 섭취하는 경우 섭취량을 늘리지 않아야 한다. 이러한 한계 내에서 미리스트산 및 팔미트산이 풍부한 음식의 섭취는 이러한 특정 지방산의 함량이 ...
TY - JOUR. T1 - Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats. AU - Lee, Min Hee. AU - DeBerardinis, Ralph J.. AU - Wen, Xiaodong. AU - Corbin, Ian R.. AU - Sherry, A. Dean. AU - Malloy, Craig R.. AU - Jin, Eunsook S.. PY - 2019/12. Y1 - 2019/12. N2 - Background: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been distinguished. Here we examined pyruvate entry into the tricarboxylic acid (TCA) cycle through PDH versus PC in vivo using hepatoma-bearing rats. Methods: Hepatoma-bearing rats were generated by intrahepatic injection of H4IIE cells. Metabolism of 13C-labeled glycerol, a physiological substrate for both gluconeogenesis and energy production, was measured with 13C NMR analysis. The concentration of key metabolites and the expression of relevant enzymes were measured in hepatoma, ...
Glutamine is taken up into the rat hepatoma cell line H4-IIE-C3 by a Na+-dependent transport system which is specific for glutamine, alanine, serine, cysteine and asparagine and does not tolerate substitution of Na+ by Li+. Glutamine transport was relatively weakly inhibited by a 50-fold excess of leucine and was not inhibited by phenylalanine or N-methyl aminoisobutyrate. These general properties are characteristic of the recently identified ASCT/B0 family of transporters. Using a reverse transcriptase PCR-based homology cloning approach, we have characterized a cDNA for a novel member of this transporter family (H4-ASCT2) from H4-IIE-C3 cells. The cDNA encodes a 551-amino acid protein which exhibits similarities of between 75 and 85% with ASCT/B0 transporters previously cloned from other sources. When expressed in Xenopus oocytes, this transporter catalyses Na+-dependent glutamine uptake with characteristics very similar to those of glutamine uptake into the H4-IIE-C3 cells. This newly ...
Glutamine is taken up into the rat hepatoma cell line H4-IIE-C3 by a Na+-dependent transport system which is specific for glutamine, alanine, serine, cysteine and asparagine and does not tolerate substitution of Na+ by Li+. Glutamine transport was relatively weakly inhibited by a 50-fold excess of leucine and was not inhibited by phenylalanine or N-methyl aminoisobutyrate. These general properties are characteristic of the recently identified ASCT/B0 family of transporters. Using a reverse transcriptase PCR-based homology cloning approach, we have characterized a cDNA for a novel member of this transporter family (H4-ASCT2) from H4-IIE-C3 cells. The cDNA encodes a 551-amino acid protein which exhibits similarities of between 75 and 85% with ASCT/B0 transporters previously cloned from other sources. When expressed in Xenopus oocytes, this transporter catalyses Na+-dependent glutamine uptake with characteristics very similar to those of glutamine uptake into the H4-IIE-C3 cells. This newly ...
Results The induction of premalignant lesions after 24 weeks and of HCC-like tumours after 42 weeks by DEN in mice was accompanied by significant leucocyte infiltration in the liver and upregulation of distinct intrahepatic chemokines (CCL2, CCL5, CXCL9). Macrophages and CD8 (cytotoxic) T cells were most prominently enriched in tumour-bearing livers, similar to samples from human HCC. Myeloid-derived suppressor cells (MDSC) increased in extrahepatic compartments of DEN-treated mice (bone marrow, spleen). The contribution of immune cell subsets for DEN-induced hepatocarcinogenesis was functionally dissected. In D6−/− mice, which lack the chemokine scavenging receptor D6, hepatic macrophage infiltration was significantly increased, but tumour formation and progression did not differ from that of WT mice. In contrast, progression of hepatic tumours (numbers, diameters, tumour load) was strikingly enhanced in T-/B cell-deficient Rag1−/− mice upon DEN treatment. When mice deficient for B ...
Hepatocellular carcinoma is the most common cancer occurring in males in the world and has an annual incidence worldwide of 1 million. There are variations in its geographical distribution. It is the second most common cancer in Southeast Asia, including Hong Kong and ranks third among males in China ...
Thiamethoxam (CGA293343; 3-(2-chloro-thiazol-5-ylmethyl)-5-methyl-[1,3,5]oxadiazinan-4-ylidene-N-nitroamine) was shown to increase the incidence of mouse liver tumors in an 18-month study; however, thiamethoxam was not hepatocarcinogenic in rats. Thiamethoxam is not genotoxic, and, given the late life generation of mouse liver tumors, suggests a time-related progression of key hepatic events that leads to the tumors. These key events were identified in a series of studies of up to 50 weeks that showed the time-dependent evolution of relatively mild liver dysfunction within 10 weeks of dosing, followed by frank signs of hepatotoxicity after 20 weeks, leading to cellular attrition and regenerative hyperplasia ...
Guadalupe S. López-Álvarez, Tomasz K. Wojdacz, Claudia M. García-Cuellar, Hugo C. Monroy-Ramírez, Miguel A. Rodríguez-Segura, Ruth A. Pacheco-Rivera, Carlos A. Valencia-Antúnez, Nancy Cervantes-Anaya, Ernesto Soto-Reyes, Verónica R. Vásquez-Garzón, Yesennia Sánchez-Pérez, Saúl Villa-Treviño ...
Hepatocarcinogenesis comprises of multiple, complex steps that occur after liver injury and usually involve several pathways, including telomere dysfunction, cell cycle, WNT/β-catenin signaling, oxidative stress and mitochondria dysfunction, autophagy, apoptosis, and AKT/mTOR signaling. Following liver injury, gene mutations, accumulation of oxidative stress, and local inflammation lead to cell proliferation, differentiation, apoptosis, and necrosis. The persistence of this vicious cycle in turn leads to further gene mutation and dysregulation of pro- and anti-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-10, IL-12, IL-13, IL-18, and transforming growth factor (TGF)-β, resulting in immune escape by means of the NF-κB and inflammasome signaling pathways. In this review, we summarize studies focusing on the roles of hepatocarcinogenesis and the immune system in liver cancer. In addition, we furnish an overview of recent basic and clinical studies to provide a strong foundation to
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|p||strong|Technical Advantage: |/strong| This formulation in not available from other suppliers|br /| McCoys 5A medium was originally formulated to meet the culture requirements of Novikoff Hepatoma cells, and has been found to support the indefinite proliferation of Walker256 carcinoma cells along with a wide range of human and rat normal and transformed cells.  Originally modified by Iwakata and Grace, this version of McCoys 5A includes increased levels of inositol and glucose, and contains L-glutamine and 25 mM HEPES.|br /| -  Complete Certificate of Analysis available for each production lot, along with full formulation information|br /| -  Produced under the highest industry standards to ensure superior results|/p|
Morales, M H.; Brown, P C.; and Papaconstantinou, J, "Regulation of alpha-fetroprotein synthesis in cultured mouse hepatoma cells (hepa-2). Abstr." (1978). Subject Strain Bibliography 1978. 821 ...
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HTC has finally announced the successor to the HTC One, and theyve decided to call it the HTC One. Well, sort of - its the HTC One M8. Weve been digging into the phone as much as possible over the last couple of days, and so far theres a lot to be happy about here. HTC has produced a phone that feels incredible in the hand, is wicked smooth as you glide through the OS, and has more than a few tricks to keep you busy. Weve been spending a lot of time with the Ultrapixel-powered Duo Camera, and found it more than a little capable when compared to the iPhone 5S and Moto X. HTC Sense has gotten a big boost as well, such that this new version is being called "Sixth Sense" by HTC. Blinkfeed in particular has caught our eye, such that the overhauled aggregate tool has earned itself a spot in our App of the Week. ...
rat hepatoma adhesive factor: MW 70,000 thermostable glycoprotein from surface of rat ascitic hepatoma cells; dimer has MW 130,000
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Benchmark results for the new HTC One may not truly reflect the performance owners will see in daily use, it has been claimed. A report found the HTC flagship scored highly in one benchmark when compared to other recent releases, while a slightly different benchmarking app from the same developers s
Wyeth (now Pfizer) was developing HTC 867 for the oral treatment of cognitive impairment associated with schizophrenia. HTC 867 was in early clinical
The retail box of the HTC Desire HD has pretty standard contents: a USB charger, standard microUSB data cable and the usual paperwork. Theres a...
US Cellular became the first regional US carrier to pick up Windows Phone 7 with the HTC 7 Pro. Its device is a more straightforward adaptation of the Arrive for Sprint and shares its CDMA networking along with the NoDo update to Windows Phone 7. Its version is also closer to stock, although it co
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Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis Green tea;hepatocarcinogenesis;initiation;GST-P;rats; The purpose of this study was to investigate the effects of green tea ingestion on hepatocarcinogenesis before and after its initiation. Male Sprague-Dawley rats were fed an AIN76A diet with or without green tea. Initiation was induced by a single dose (200 mg/kg) of diethylnitrosamine at week 4 and 0.02% (w/w) 2-acetylaminofluorene was supplied in the diets. The control group had free access to water for 13 weeks (CTR13). Tea infusion was provided from the beginning of the experiment for 13 weeks (PRE13) or from the post-initiation stage until week 13 (POST13). Three other groups (CTR24, PRE24 and POST24) were added to examine the longer-term effects (24 weeks) with the same experimental design. The percentage area of liver sections that were positive for hepatic placental glutathione S-transferase (GST-P), which was used as a marker of preneoplastic
The natural vitamin, pyridoxine, in the millimolar range is toxic to cultured rat hepatoma cells. A pyridoxine-resistant Fu5-5 rat hepatoma cell line was established by a stepwise increase in the concentration of pyridoxine in the medium. The newly established cell line, referred to as clone 10 (Cl. 10), is resistant to killing by pyridoxine in concentrations up to 5 mm. Saturation kinetics for the uptake of [3H]pyridoxine into Fu5-5 and Cl.10 cells revealed that Fu5-5 cells take up 10 times more [3H]pyridoxine than do Cl.10 cells. Whereas the Vmax value for the uptake of [3H]pyridoxine was the same for both cell lines, the apparent Km for the Cl.10 cells was 12.5 µm compared to 0.71 µm for the Fu5-5 cells. However, intracellular levels of pyridoxal 5′-phosphate were 69% higher in Cl.10 cells than in the parental line. The resistant line is neither a permeability mutant nor deficient in pyridoxal kinase. Cl.10 cells contain 37% more adenosine 5′-triphosphate than do Fu5-5 cells and have a ...
MAIN RESULTS: We identified two RCTs and one CCT (total number of participants 149) evaluating the use of amifostine versus no additional treatment in the original version of the review; the updates identified no additional studies. Two studies included children with osteosarcoma, and the other study included children with hepatoblastoma. Children received cisplatin only or a combination of cisplatin and carboplatin, either intra-arterially or intravenously. Pooling of results of the included studies was not possible. From individual studies the effect of amifostine on symptomatic ototoxicity only (i.e. National Cancer Institute Common Toxicity Criteria version 2 (NCICTCv2) or modified Brock grade 2 or higher) and combined asymptomatic and symptomatic ototoxicity (i.e. NCICTCv2 or modified Brock grade 1 or higher) were uncertain (low-certainty evidence). Only one study including children with osteosarcoma treated with intra-arterial cisplatin provided information on tumour response, defined as ...
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Pfizer is currently recruiting for the NCT00106054 Colorectal Neoplasms, Liver Neoplasms Cancer trial. Review trial description, criteria and location information here.