Addition of selective internal radiation therapy (SIRT) failed to improve progression-free survival in non-resectable colorectal cancer liver metastases.
Eicosapentaenoic acid (EPA) is a naturally occuring omega-3 polyunsaturated fatty acid found in oily fish. EPA has anti-colorectal (bowel) cancer activity in experimental models. This trial will test whether EPA reduces markers of tumour growth, and is safe and well tolerated,in patients with colorectal cancer liver metastases awaiting surgery ...
Estrogen plays an important role in the development of some cancers. However, previous studies on the influence of estrogen on colorectal cancer (CRC) have had conflicting conclusions, and there have been few reports on estrogens and liver metastasis. The aim of this study was to explore the prognostic impact of estrogens on CRC with liver metastasis. Eighty-six patients with CRC including 43 synchronous liver metastases were studied. Estrogen receptor β (ERβ) levels were assayed by immunohistochemistry in liver metastasis, CRC and adjacent normal tissues. Serum estrogen levels were measured by radioimmunoassay. The correlation between staining, clinicopathological parameters, and prognostic power were analyzed statistically. Significant differences were found in ERβ expression between liver metastasis (P = 0.012) and CRC (P = 0.002) compared to adjacent normal tissues. Serum estrogen levels in patients with liver metastases were significantly lower than those without liver metastasis (P = 0.012).
BioAssay record AID 228035 submitted by ChEMBL: Inhibitory activity against Colchicine resistant parent primary liver carcinoma (PLC) cell line PLC/PRF/5.
TY - JOUR. T1 - Effect of the molar ratio of branched-chain to aromatic amino acids on growth and albumin mRNA expression of human liver cancer cell lines in a serum-free medium. AU - Saito, Y.. AU - Saito, H.. AU - Nakamura, M.. AU - Wakabayashi, K.. AU - Takagi, T.. AU - Ebinuma, H.. AU - Ishii, H.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Supplementation of branched-chain amino acids (BCAAs) is often used for the treatment of hepatic encephalopathy and low albuminemia in Japan. In this scenario, although many cases are complicated with hepatocellular carcinoma in chronic viral infection, the effect of BCAA levels on hepatocellular carcinoma cells remains unclear. We investigated the effect of the molar ratios of BCAAs to aromatic amino acids (AAAs) on the growth and albumin mRNA expression of cultured human liver cancer cell lines, HCC-M, HCC-T, PLC/PRF/5, and Hep G2. To exclude the effect of fetal serum in culture media on modification of the growth and albumin transcription of cell lines, we used ...
The liver is an organ that develops primary and metastatic tumors. Hepatocellular carcinoma (HCC) is the fifth common type of cancer worldwide and the third leading cause of cancer death (1). The median survival is approximately 6 to 20 months after diagnosis for the intermediate and advanced stages, and the 5-year survival of patients with HCC is less than 30%. Even after apparently curative surgical resection, recurrent HCC develops in 80% of patients within 5 years because of intrahepatic metastasis. For unresectable HCC, different treatment modalities are available, including radiation, radioembolization, systemic chemotherapy, and molecularly targeted therapy. Oral sorafenib, which is a multityrosine kinase inhibitor, is currently the first-line treatment for advanced HCC but its effectiveness is limited (2). The liver is also a common site of metastasis from other solid tumors, especially tumors originating from the intra-abdominal organs, including the stomach, pancreas, colon, ...
TY - JOUR. T1 - Pathology of primary liver cancer. AU - Lapis, Károly. AU - Johannessen, Jan Vincents. PY - 1979/1/1. Y1 - 1979/1/1. N2 - After a brief survey of the factors that play a role in the etiopathogenesis of human hepatocellular carcinomas, a detailed description is given of the macroscopic and microscopic features of human liver cancers as well as their association with cirrhosis. The ultrastructural features of liver cancers of various degrees of differentiation are described. The mode of spread, metastasis formation of primary liver cancers, and most frequent causes of death of liver cancer patients are reviewed.. AB - After a brief survey of the factors that play a role in the etiopathogenesis of human hepatocellular carcinomas, a detailed description is given of the macroscopic and microscopic features of human liver cancers as well as their association with cirrhosis. The ultrastructural features of liver cancers of various degrees of differentiation are described. The mode of ...
CHICAGO -- Bevacizumab (Avastin) given before surgery for curative resection of liver metastases from colorectal cancer did not increase the risk of bleeding, researchers reported here.
A study released in the July 2016 issue of the American Journal of Roentgenology found that biphenotypic primary liver carcinoma may be misclassified as hepatocellular carcinoma.
Background After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery. Consequently, we examined the expression pattern and prognostic value of miR-19b in samples from these patients. Methods We performed a miRNA microarray to detect differential expression of microRNAs (miRNAs) in 5 paired samples of HCC and non-tumoral adjacent liver tissue and a quantitative real-time polymerase chain reaction (PCR) analysis to validate the results in 81 paired samples of HCC and adjacent non-tumoral liver tissues. We examined the associations of miR-19b expression with clinicopathological parameters and survival. MiR-19b was knocked down in Hep3B and an mRNA microarray was performed to detect the affected genes. Results In both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001). The ...
Background After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery. Consequently, we examined the expression pattern and prognostic value of miR-19b in samples from these patients. Methods We performed a miRNA microarray to detect differential expression of microRNAs (miRNAs) in 5 paired samples of HCC and non-tumoral adjacent liver tissue and a quantitative real-time polymerase chain reaction (PCR) analysis to validate the results in 81 paired samples of HCC and adjacent non-tumoral liver tissues. We examined the associations of miR-19b expression with clinicopathological parameters and survival. MiR-19b was knocked down in Hep3B and an mRNA microarray was performed to detect the affected genes. Results In both the miRNA microarray and real-time PCR, miR-19b was significantly overexpressed in the HCC tumor compared with adjacent non-tumor liver tissues (P < 0.001). The ...
Radioembolization (RE) is an emerging treatment strategy for patients with primary hepatic malignancies and metastatic liver disease. Though RE is primarily performed in the palliative setting, a shift toward the curative setting is seen. Currently, hepatic resection and in selected cases liver transplantation are the only curative options for patients ... read more with a hepatic malignancy. Unfortunately, at diagnosis most patients are not eligible for liver surgery due to the imbalance between the necessary liver resection and the remaining liver remnant. However, in borderline resectable cases, tumor volume reduction and/or increasing the future liver remnant can lead to a resectable situation. The combination of selective tumor treatment, the induction of hypertrophy of untreated liver segments, and its favourable toxicity profile make RE an appealing strategy for downstaging. The present review discusses the possibilities for RE in the preoperative setting as a downstaging tool or as a ...
Metastatic liver cancer occurs due to the spreading of a primary cancer to the liver. Though incurable, you can try various treatment measures to get relief.
Background Age-adjusted liver cancer mortality rates have been increasing for both men and women in Japan since 1970 ; however, increases in mortality rates in men are much greater than those in women. Hepatitis C virus infections and heavy alcohol consumption are considered to be the major risk factors of liver cancer deaths in Japanese. The...
Featured Article: Phase II Trial of Hepatic Artery Infusional and Systemic Chemotherapy for Patients With Unresectable Hepatic Metastases From Colorectal Cancer: Conversion to Resection and Long-term Outcomes. Dangelica MI, Correa-Gallego C, Paty PB, et al. Ann Surg. 2014 Mar 21. [Epub ahead of print]. Summary: The rate of conversion of unresectable colorectal liver metastases (CRLM) to resectable CRLM has improved with modern systemic chemotherapy and biologic therapy. Results of recent studies, including randomized trials, report conversion rates of 20-38%. The combination of hepatic artery infusional (HAI) chemotherapy with systemic chemotherapy has become an attractive option for the treatment of unresectable CRLM owing to the high response rates observed in previous published studies.. This prospective phase II trial aimed to evaluate, as a primary endpoint, the conversion rate to complete resection (resectability rate) in patients with unresectable CRLM treated with HAI fluorodeoxyuridine ...
REFERENCES 1 Landis SH, Murray T, Bolden S, et al. Cancer Statistics. CA Cancer J Clin. 1999;49:8-31. 2 American Cancer Society.Cancer Facts & Figures, 2013.Atlanta, ACS, 2013:5. 3 Seidensticker R, Denecke T, Kraus P, et al. Matched-pair comparison of radioembolization plus best supportive care versus best supportive care alone for chemotherapy refractory liver-dominant colorectal metastases. Cardiovasc Intervent Radiol. 2011 July 29. [Epub ahead of print] 4 Jakobs TF, Hoffman RT, Dehm K, et al. Hepatic yttrium-90 radioembolization of chemotherapy-refractory colorectal cancer liver metastases. J Vasc Interv Radiol. 2008;19(8):1187-1195. 5 Gray B, van Hazel G, Hope M, et al. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol. 2001;12(12):1711-1720. 6 van Hazel G, Blackwell A, Anderson J, et al. Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus ...
The latest liver cancer risk factors statistics for the UK for Health Professionals. See data for factors associated with increased risk, decreased or no risk and more.
HONGFU, Liu et al. The Role and Significance of Bcl-2 and Bax in the Hepatic Carcinoma. Int. J. Morphol. [online]. 2012, vol.30, n.4, pp.1466-1473. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022012000400032.. This study aimed to observe the regularity of liver cell apoptosis and expression of apoptosis related gene Bcl-2 and Bax in the induced cancer, and explore the relationship between apoptosis and the development of liver cancer. In this study, 84 rats were used, 72 rats as experimental group induced by drinking water containing DEN, 12 rats as control group (CG). After laparotomy, the form, color, texture of the liver and metastatic tumor in both control and experimental groups were observed and recorded. The metastatic tumor and the liver tissue were sectioned and stained with hematoxylin-eosin staining to demonstrate the characteristic in morphological changes, the Hoechst 33342 fluorescent staining was applied to show and count the rate of apoptotic cell, and the in situ ...
Despite the use of alternative therapy strategies surgical resection of colorectal liver metastases remains the treatment of choice and is associated with long-term survival in a significant number of patients [1, 2]. After curative resection of colorectal liver metastases the 5-year survival rate ranges from 20% to 51% depending on preoperative selection criteria and published series [3]. However, up to 75% of resected patients will develop extra- or intrahepatic tumor recurrence [4]. One possible cause for this tumor recurrence may be intraoperative hematogenous tumor cell dissemination due to mechanical manipulation of the tumor during hepatic resection [5].. Recently, RT-PCR based protocols were developed for the detection of disseminated tumor cells [6]. We developed a sensitive and specific CK 20 RT-PCR system for detection of disseminated colorectal cancer cells in blood, bone marrow and lymph nodes [7-9]. By using the CK 20 RT-PCR, we demonstrated that there is a significantly enhanced ...
TY - JOUR. T1 - Expanding the role of surgical therapy for colorectal liver metastases. AU - Choti, Michael A.. PY - 2012/6. Y1 - 2012/6. N2 - Management of patients with colorectal metastases to the liver often requires complex multidisciplinary care. Improved short-term and long-term outcomes with hepatic resection have resulted in an increasing aggressive surgical approach for many of these patients. Even with more contemporary definition of resectability, however, most patients may not be initial candidates for resection. The use of other preoperative systemic and liver-directed therapies offers the opportunity to expand the number of patients who may be candidates for curative-intent strategies. Systemic therapies can achieve responses which are capable of downsizing unresectable disease to a resectable status. Local therapies can also be used in a similar way. Yet, the optimal application and timing of these multimodality approaches to expand the role of surgical therapy remain ...
Liver cancer is not common in the United States.. Liver cancer is the fourth most common cancer and the third leading cause of cancer death in the world. In the United States, men, especially Asian/Pacific Islander men, have an increased risk of liver cancer. The number of new cases of liver cancer and the number of deaths from liver cancer continue to increase, especially among middle-aged black, Hispanic, and white men. People are usually older than 40 years when they develop this cancer. Finding and treating liver cancer early may prevent death from liver cancer. Being infected with certain types of the hepatitis virus can cause hepatitis and increase the risk of liver cancer.. Hepatitis is most commonly caused by the hepatitis virus. Hepatitis is a disease that causes inflammation (swelling) of the liver. Damage to the liver from hepatitis that lasts a long time can increase the risk of liver cancer. There are six types of the hepatitis virus. Hepatitis A (HAV), hepatitis B (HBV), and ...
For more than 20 years, BroadcastMed has been innovating digital strategies for healthcare organizations. The company was first in the world to broadcast live surgeries on the internet using its ORLive solution which provides an intimate look inside the operating room.. ...
On World Cancer Day, the World Hepatitis Alliance is calling for the establishment of comprehensive hepatitis strategies to help prevent the 800,000 liver cancer deaths each year.. London, 4 February 2016 Rock-icon David Bowie died recently at the age of 69 after a battle with what is being reported as liver cancer. Each year, globally, more than 800,000 people die from liver cancer, the second biggest cancer killer.i Yet, a high majority of these deaths are completely preventable.. Liver cancer comes in two forms: primary liver cancer, where it begins in the liver, and secondary, where it spreads from other organs. Primary liver cancer, the most prevalent liver cancer worldwide, can be attributed to heavy drinking and other unhealthy lifestyle choices, but is most commonly caused by having a long-term infection with the hepatitis B or hepatitis C virus - which in turn accounts for the biggest cause of the 642,500 liver cancer related deaths per year, globally.i. What many people dont realise ...
Although variable prognostic factors (patient age, number and size of metastases, lymph node infiltration, stage of primary disease, prior local recurrence of the primary tumor, and clear resection margin of metastatic lesion) have been suggested in some reports, many authors describe the importance of hormone receptor status as a prognostic factor for the primary tumor after complete resection of BCLM [12,17,20]. Golse and Adam [23] suggested that the best results after the resection of BCLM are achieved after applying selection criteria based on small metastases (, 4-5 cm), minor hepatectomy, radical resection (ideally R0, or R1), stable disease after neoadjuvant therapy, and a delay between primary and secondary lesions longer than 1 or 2 years. Howerver, the age of the patient, her hormone receptor status, and HER2 overexpression are not strong predictors of overall survival [23]. In our study, time to recurrence was relatively short if the metastatic lesion was larger than 5 cm, or there ...
October is Liver Cancer Awareness Month. It may be a sleeper of a event when compared to other health campaigns, but for us who live with viral hepatitis, its an uncomfortable but critical reminder of the importance of monitoring our liver health to prevent cancer.. Viral hepatitis, especially B and C, are viral infections that can cause liver cancer (also called hepatocellular carcinoma or HCC.) Researchers are still studying why some people are more prone to liver cancer, but we who live with chronic hepatitis B or C have a 25 to 40 percent lifetime risk of developing liver cancer. The infection, which hijacks our liver cells to manufacture more virus, causes inflammation, scarring and even cancer as the liver cells grow out of control.. The longer we are infected with viral hepatitis, the higher our risk of developing liver cancer. While liver cancer often occurs in people with cirrhosis (severe liver scarring), some of us develop cancer without cirrhosis.. Liver cancer is also a threat to ...
05 Oct 2017. A new article published by JAMA Oncology reports the results of the Global Burden of Disease 2015 study on primary liver cancer incidence, death and years of healthy life lost in 195 countries or territories from 1990 to 2015.. Liver cancer is among the leading causes of cancer death worldwide.. The article by the Global Burden of Disease Liver Cancer Collaboration and corresponding author Christina Fitzmaurice, M.D., M.P.H., of the University of Washington, Seattle, estimates there were 854,000 new cases of liver cancer and 810,000 deaths globally in 2015.. Cases of incident (new) liver cancer increased 75 percent between 1990 and 2015, which was mostly explained by population aging and population growth, according to the authors.. In 2015, hepatitis B virus was the leading cause of new cases of liver cancer, deaths and disability-adjusted life-years (DALYS), which is the sum of years of life lost and years lived with disability such that one DALY can be interpreted as one lost ...
Advances in surgical fields and chemotherapy regimens have been increasing long-term outcomes for patients with Colorectal Liver Metastases (CRLM). The liver resection re..
The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and metastasis is regarded as the major cause of HCC-associated lethality. In this study, we have analysed the TCGA whole-transcriptome sequencing data of paired human HCC samples (n=50), and identified Forkhead Box M1 (FOXM1) and Centromere Protein F (CENPF) to be the top-listing upregulated genes. Interestingly, both of them are the essential components in cell-cycle progression. FOXM1 encodes for the cell-cycle-dependent transcription factor that regulates genes for DNA replication and mitosis, while CENPF encodes for the centromere protein that is required for kinetochore function and chromosome segregation in mitosis.. We hypothesized that the upregulation of FOXM1-CENPF signaling axis may drive hepatocarcinogenesis. In our human HCC cohort (n=34), FOXM1 and CENPF were shown to be upregulated compared with the non-tumorous liver tissues, and their mRNA expressions were positively correlated (p,0.0001). ...
Only a small amount of liver cancers are found early and can be totally removed by surgery. Less that 30 percent of patients are able to have their tumor totally removed. The overall five year survival rate for liver cancer is about 9 percent. One reason for this low number is that many patients with liver cancer have cirrhosis of the liver which could be fatal in itself.. The numbers do sound grim, but not necessarily what will happen, everyone is unique and this cancer can be treated. Surgery, chemotherapy and radiation are used to combat primary liver cancer. One way that liver cancer can be cured is by a liver transplant. This option is for those patients with small liver tumors whos cancer cannot be surgically removed. Over 2500 transplants were performed with people with liver cancer in the last two years. The good news is that the five year survival for these patients was 70 percent.. Some specific treatments available for liver cancer:. ...
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic
The aim of this study was to determine the effect of chemotherapy on the accuracy of CT scan for the preoperative evaluation of colorectal liver metastases (LM). Between 1999 and 2005, 92 patients wit
A minority of patients with colorectal liver metastases and hepatobiliary cancer (primary liver cancer) are candidates for surgery, but there are no curative treatment options for these patients. Their median survival time is 3 to 12 months. Stereotactic radiation (SRT) (highly conformal radiotherapy (CRT)) is a treatment option for these patients with unresectable liver cancer, now possible due to improvements in our ability to localize and immobilize liver tumors and an improved understanding of the partial liver volume tolerance to radiation. SRT should permit liver tumors to be treated to tumorcidal doses while sparing the uninvolved liver, decreasing the risk of treatment related normal tissue toxicity. With such conformal radiation, it is possible to deliver radiation in fewer fractions than traditionally required, which should be more convenient for patients. In this study, CRT will be delivered during shallow breathing or breath hold to minimize organ motion due to breathing, decreasing ...
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US Pharm. 2016;41(12):HS-20.. Reoviruses, which cause childhood coughs and colds, could help in the fight against primary liver cancer, according to a study by University of Leeds researchers in England. The reovirus, say the scientists, is also able to kill the hepatitis C virus, which is a common cause of primary liver cancer and the third highest cause of cancer deaths worldwide.. Study coleader Dr. Stephen Griffin, associate professor of viral oncology at the University of Leeds, said, "Ultimately we hope that by simultaneously treating the tumour, and the hepatitis virus that is driving the growth of the tumour, we may provide a more effective therapy and improve the outcomes for patients.". The University of Leeds team found that reovirus was successful against liver cancer cells grown in the laboratory as well as those collected from patients undergoing surgery. The study results were published in the journal Gut.. ...
Liver metastasis occurs when cancerous tumor cells spread to the liver from another part of the body. – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 88e988-NzRlM
BMI, WC, and type II diabetes mellitus were associated with higher risks of liver cancer in this prospective analysis of 1.57 million participants enrolled in 14 U.S.-based cohort studies. Higher BMI was associated with liver cancer in a dose-response manner, and associations were robust after controlling for smoking, alcohol intake, and other risk factors. High WC was associated with higher risks of liver cancer, and these associations were attenuated after including BMI in the statistical models, suggesting shared effects of both BMI and WC on liver cancer risk, perhaps owing to these phenotypes being correlated with visceral adiposity. Type II diabetes mellitus was a strong predictor of liver cancer risk, and these results were robust even at nonobese BMI levels and after controlling for their shared risk factors. Some evidence of heterogeneity was detected across studies when sensitivity analyses were conducted in individual participant meta-analyses, which seemed to be the result of our ...
Research should document indications for treatment, details of patient selection and details of adjuvant and prior treatments. Outcome measures should include complications, survival and quality of life. Data from welldesigned trials comparing the procedure against other forms of management would be particularly useful, but prospective observational studies may also be of value ...
Pfizer is currently recruiting for the NCT00106054 Colorectal Neoplasms, Liver Neoplasms Cancer trial. Review trial description, criteria and location information here.
Even after a functional cure for hepatitis B is achieved, the risk for hepatocellular carcinoma persists in older patients, new research warns. Medscape Medical News
초록. Liver resection is the only curative treatment for patients with colorectal liver metastases (CLMs). Neoadjuvant chemotherapy can improve resectability but has a potential harmful effect on the nontumorous liver. Patients with chemotherapy-induced hepatic injury undergoing liver surgery have higher risks of post-resectional morbidity. We present two cases of patients without pre-existent liver disease treated with oxaliplatin-based chemotherapy followed by surgical resection of their CLMs. Their intra-operative liver specimen showed morphologic abnormalities characteristic of nodular regenerative hyperplasia (NRH). NRH led to portal hypertension in both patients that resulted in deleterious post-resectional complications and death of one patient. Interestingly, the other patient underwent two repeat nonanatomic liver resections because of recurrent CLMs. The intra-operative liver specimen still showed signs of NRH and sinusoidal congestion, but the post-resectional courses were ...
High consumption of fat and sugar are linked to the development of liver cancer. A diet rich in broccoli was found to reverse liver damage and reduce cancer risk.
A large European study now suggests that many diagnoses of cirrhosis and liver cancer come too late, and that diabetes might be an independent risk factor.
Methodical studies and directions for the measurement of fatty acid curves in capillary blood However, the adolescents of Ethiopian origin born in Israel had abortion request rates that generic cialis india were more comparable to other Israelis than to women born in Ethiopia who subsequently immigrated to Israel. Hybridization of nucleic acids with secondary structure is involved in many biological processes and technological applications. Effect of Coriolis accelerations on the ability of humans to determine the sense of the gravitational vertical We identified host genes involved in WT1 gene modulation of human liver cancer cell lines in vitro, and further characterized genes related to apoptosis.. Here we demonstrate an all-optical magnetometer where the optical cell for Faraday rotation spectroscopy is augmented with a low finesse cavity. We propose a compact and external off-axis interferometric module that generic cialis india can achieve interference with low spatial coherence ...
Resection is the gold standard in the treatment of liver metastases from colorectal cancer. An internal cooled radiofrequency electrode was described to achieve tissue coagulation to a greater margin width. The aim of this study is to determinate if a RFassisted transection device (RFAT) has any effect on local hepatic recurrence (LHER) compared to conventional technologies. A study population of 103 patients who had undergone a hepatic surgical resection was retrospectively analysed. Patients were classified into two groups according to the device used: a RF-assisted device (RFAT group; n=45) and standard conventional devices (control group; n=58). LHER was defined as any growing or enhancing tumour in the margin of hepatic resection during follow-up. Cox proportional models were constructed and variables were eliminated only if p,0.20 to protect against residual confounding. To assess the stability of Coxs regression model and its internal validity, a bootstrap investigation was also ...
Researchers at Osaka City University Graduate School of Medicine introduced sorafenib to patients with advanced stages of the liver cancer hepatocellular carcinoma (HCC) and measured the amount of 16 circulating soluble immune checkpoint proteins. Their data suggest that a high amount of sBTLA proteins may be a marker of overall survival in patients with HCC.
Survival trends for primary liver cancer, 1995-2009: analysis of individual data for 578,740 patients from 187 population-based registries in 36 countries (CONCORD-2)
Control of intra-operative bleeding is a primary goal in liver surgery and is traditionally achieved by vascular clamping. The short-term adverse effect of ischemia/reperfusion (I/R) resulting from temporary vascular clamping on hepatocellular function have been well documented. In this thesis we describe for the first time how I/R also affects ... read more long-term outcome by accelerating the outgrowth of (residual) colorectal micrometastases. Different aspects of this phenomenon are described: the parameters that predispose for the adverse effects of I/R on tumor growth, the effect of alternative clamping techniques on metastasis outgrowth, the mechanisms that underlie I/R-accelerated tumor growth and pharmacological interventions that interfere with tumor growth after I/R. Finally, the stimulatory effect of thermal ablation, which is associated with pathophysiological events similar to I/R, on the outgrowth of residual tumor cell deposits is described, including interventional strategies to ...
Danish study shows an overwhelming benefit of Hepatitis C antiviral therapy, regardless of whether or not a sustained viral response is achieved.
Primary Liver Cancer: Surveillance, Diagnosis and Treatment, 9781280997099, available at Book Depository with free delivery worldwide.