TY - JOUR. T1 - Treatment for ascites in adults with decompensated liver cirrhosis. T2 - a network meta-analysis. AU - Benmassaoud, Amine. AU - Freeman, Suzanne C. AU - Roccarina, Davide. AU - Plaz Torres, Maria Corina. AU - Sutton, Alex J. AU - Cooper, Nicola J. AU - Iogna Prat, Laura. AU - Cowlin, Maxine. AU - Milne, Elisabeth Jane. AU - Hawkins, Neil. AU - Davidson, Brian R. AU - Pavlov, Chavdar S. AU - Thorburn, Douglas. AU - Tsochatzis, Emmanuel. AU - Gurusamy, Kurinchi Selvan. N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.. PY - 2020/1/16. Y1 - 2020/1/16. N2 - ...
TY - JOUR. T1 - Spontaneous bacterial peritonitis in patients with hepatitis B-related cirrhosis and hepatocellular carcinoma. AU - Wang, Sun Sang. AU - Tsai, Yang Te. AU - Lee, Shou Dong. AU - Chen, How Tshung. AU - Lu, Chi Wen. AU - Lee, Fa Yauh. AU - Jeng, Jin Shiung. AU - Liu, Yung Ching. AU - Lo, Kwang Juei. PY - 1991. Y1 - 1991. N2 - To delineate the natural clinical course of spontaneous bacterial peritonitis in hepatitis B-related cirrhosis and to determine if it occurs in hepatocellular carcinoma, a prospective survey was conducted in 262 patients over 2 1 2 years. The in-hospital incidence and mortality rates of spontaneous bacterial peritonitis were 21.6% and 36.4%, respectively, in cirrhosis and 7.3% and 50% in hepatocellular carcinoma. In cirrhosis, the cumulative probability of annual recurrence of spontaneous bacterial peritonitis was 47.3%, which was significantly higher than the annual probability of occurrence of 11.3% in those with no previous attack (P ,0.0001). The ...
TY - JOUR. T1 - Outcome after liver transplantation for cirrhosis due to alcohol and Hepatitis C. T2 - Comparison to alcoholic cirrhosis and Hepatitis C cirrhosis. AU - Singal, Ashwani K.. AU - Hmoud, Bashar S.. AU - Guturu, Praveen. AU - Kuo, Yong Fang. PY - 2013/9. Y1 - 2013/9. N2 - BACKGROUND AND AIM: Data on outcome of patients after liver transplantation (LT) for cirrhosis due to hepatitis C virus (HCV+) alcohol are limited. METHODS AND RESULTS: Analysis from United Network for Organ sharing data set (1991 to 2010) for cirrhotics with first LT for HCV (group I, N=17,722), alcohol or alcoholic cirrhosis (AC; group II, N=9617), and alcohol+HCV (group III, N=6822). Five-year graft and patient survival for group III were similar to group I (73% vs. 69%; P=0.33 and 76% vs. 76%; P=0.87) and worse than group II (70% vs. 74%; P,0.0001 and 76% vs. 79%; P,0.0001). Cox regression analysis adjusted for recipient and donor characteristics showed (a) graft survival for group III similar to group I ...
Indian childhood cirrhosis (ICC) is an almost uniformly fatal disease whose outcome may be modified with penicillamine if given at a sufficiently early stage. Twenty nine children with ICC seen in Pune, India, in 1980-7, who had survived at least five years from onset of penicillamine treatment, were reviewed aged 6.3 to 13 years. They were assessed clinically, biochemically, histologically, and by duplex Doppler ultrasound examination. None had symptoms suggestive of liver disease. There were no toxic effects of penicillamine other than asymptomatic proteinuria. Hepatosplenomegaly reduced significantly and liver function tests returned to normal in all. In four children, significant hepatosplenomegaly was associated with an abnormal duplex Doppler hepatic vein flow pattern and micronodular cirrhosis on biopsy. Clinical findings, growth and development, and ultrasound examination were normal in the remainder. Review of serial liver biopsy specimens showed a sequence of recovery from ICC through ...
Liver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors such as alcohol use and hepatitis B and C infection. We estimated annual age-specific mortality from liver cirrhosis in 187 countries between 1980 and 2010. We systematically collected vital registration and verbal autopsy data on liver cirrhosis mortality for the period 1980 to 2010. We corrected for misclassification of deaths, which included deaths attributed to improbable or nonfatal causes. We used ensemble models to estimate liver cirrhosis mortality with uncertainty by age, sex, country and year. We used out-of-sample predictive validity to select the optimal model. Global liver cirrhosis deaths increased from around 676,000 (95% uncertainty interval: 452,863 to 1,004,530) in 1980 to over 1 million (1,029,042; 670,216 to 1,554,530) in 2010 (about 2% of the global total). Over the same period,
Liver cirrhosis is a major yet largely preventable and underappreciated cause of global health loss. Variations in cirrhosis mortality at the country level reflect differences in prevalence of risk factors such as alcohol use and hepatitis B and C infection. We estimated annual age-specific mortality from liver cirrhosis in 187 countries between 1980 and 2010. We systematically collected vital registration and verbal autopsy data on liver cirrhosis mortality for the period 1980 to 2010. We corrected for misclassification of deaths, which included deaths attributed to improbable or nonfatal causes. We used ensemble models to estimate liver cirrhosis mortality with uncertainty by age, sex, country and year. We used out-of-sample predictive validity to select the optimal model. Global liver cirrhosis deaths increased from around 676,000 (95% uncertainty interval: 452,863 to 1,004,530) in 1980 to over 1 million (1,029,042; 670,216 to 1,554,530) in 2010 (about 2% of the global total). Over the same period,
Liver cirrhosis (LC) represents a late stage of progressive hepatic fibrosis characterized by distortion of the hepatic architecture and formation of regenerative nodules. The liver transplantation is one of the only effective therapies available to such patients. However, lack of donors, surgical complications, rejection, and high cost are it`s serious problems.. The potential for stem cells to differentiate into hepatocytes cells was recently confirmed. In particular, bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been applicated in the clinic for treat several human diseases such as GVHD, cardiac injury and brain injury, and displayed good tolerance and efficiency. BM-MSC has also been used to treat human liver diseases such as liver failure and liver cirrhosis. In a phase 1 study, autologous BM-MSC transplantation has potential to decrease MELD score and increase serum albumin in 4 of patients with decompensated liver cirrhosis.. The purpose of this study is to learn ...
Accepted Manuscript. Abstract Background and Aims. Non-invasive predictors identifying subjects with compensated liver disease at highest risk for transitioning to a decompensated state are lacking. We hypothesized that liver shear stiffness as measured by magnetic resonance elastography is an important non-invasive predictor of hepatic decompensation.. Methods. Among patients with advanced fibrosis undergoing magnetic resonance elastography (2007-11), a baseline cohort and follow up cohort (compensated liver disease) were established. Cause specific cox proportional hazards analysis adjusting for competing risks was utilized to determine the association between elevated liver shear stiffness and development of decompensation (hepatic encephalopathy, ascites, variceal bleeding).. Results. In the baseline cohort (n=430), subjects with decompensated liver disease had a significantly higher mean liver shear stiffness (6.8 kPa, IQR 4.9-8.5) as compared to subjects with compensated liver disease (5.2 ...
Cirrhosis is known to cause alterations in the systemic haemodynamic system. Cirrhotic cardiomyopathy designates a cardiac dysfunction that includes impaired cardiac contractility with systolic and diastolic dysfunction, as well as electromechanical abnormalities in the absence of other known causes of cardiac disease. This condition is primarily revealed by inducing physical or pharmacological stress, but echocardiography is excellent at revealing diastolic dysfunction and might also be used to detect systolic dysfunction at rest. Furthermore, measurement of circulating levels of cardiac biomarkers could improve the diagnostic assessm+ent. Cirrhotic cardiomyopathy contributes to various complications in cirrhosis, especially as an important factor in the development of hepatic nephropathy. Additionally, cirrhotic cardiomyopathy seems to be associated with the development of heart failure in relation to invasive procedures such as shunt insertion and liver transplantation. Current ...
Morphological variants of intrahepatocytic hyalin in Indian childhood cirrhosis have been analysed by electron microscopy. This structure, morphologically identical with Mallorys alcoholic hyalin, is encountered in three different forms. The most common one is composed of randomly oriented fibrils. The next common type is composed of smudgy homogeneous or finely granular material, while the least common type consists of parallel fibrils with gentle curves giving a finger-print appearance. Fragmented endoplasmic reticulum and ribosomes were frequently associated with hyalin suggesting that these organelles contribute to their formation.. ...
TY - JOUR. T1 - Influence of genetic variations in the SOD1 gene on the development of ascites and spontaneous bacterial peritonitis in decompensated liver cirrhosis. AU - Schwab, Sebastian. AU - Lehmann, Jennifer. AU - Lutz, Philipp. AU - Jansen, Christian. AU - Appenrodt, Beate. AU - Lammert, Frank. AU - Strassburg, Christian P. AU - Spengler, Ulrich. AU - Nischalke, Hans Dieter. AU - Trebicka, Jonel. PY - 2017. Y1 - 2017. N2 - BACKGROUND: The balance between generation and elimination of reactive oxygen species by superoxide dismutase (SOD) is crucially involved in the pathophysiology of liver cirrhosis. Reactive oxygen species damage cells and induce inflammation/fibrosis, but also play a critical role in immune defense from pathogens. As both processes are involved in the development of liver cirrhosis and its complications, genetic variation of the SOD1 gene was investigated. PATIENTS AND METHODS: Two SOD1 single nucleotide polymorphisms (rs1041740 and rs3844942) were analyzed in 49 ...
Also, the research study gives a complete list of all the leading players working in the United States Transient Elastography Devices market. Moreover, the financial status, company profiles, business strategies and policies, and the latest expansions in the United States Transient Elastography Devices market have been mentioned in the research study.. For more inquiry before purchase: https://www.researchnreports.com/enquiry_before_buying.php?id=61553. Table of Contents 1 Industry Overview of Transient Elastography Devices. 2 Manufacturing Cost Structure Analysis of Transient Elastography Devices. 3 Technical Data and Manufacturing Plants Analysis of Transient Elastography Devices. 4 United States Transient Elastography Devices Overall Market Overview. 5 Transient Elastography Devices Regional Market Analysis. 6 United States 2011-2016E Transient Elastography Devices Segment Market Analysis (by Type). 7 United States 2011-2016E Transient Elastography Devices Segment Market Analysis (by ...
Background: Transient elastography (FibroScan) is a new, non-invasive, rapid, and reproducible method allowing evaluation of liver fibrosis by measurement of liver stiffness. In cirrhotic patients, liver stiffness measurements range from 12.5 to 75.5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease.. Methods: A total of 711 patients with chronic liver disease were studied. Aetiologies of chronic liver diseases were hepatitis C virus or hepatitis B virus infection, alcohol, non-alcoholic steatohepatitis, other, or a combination of the above aetiologies. Liver fibrosis was evaluated according to the METAVIR score.. Results: Stiffness was significantly correlated with fibrosis stage (r = 0.73, p,0.0001). Areas under the receiver operating characteristic curve (95% confidence interval) were 0.80 (0.75-0.84) for patients ...
Goh, B.J.,Khoo, H.E.,Tan, B.T.,Lee, K.H.,Hon, W.M. (2006). Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis. World Journal of Gastroenterology 12 (4) : 588-594. ScholarBank@NUS Repository ...
Goh, B.J.,Khoo, H.E.,Tan, B.T.,Lee, K.H.,Hon, W.M. (2006). Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis. World Journal of Gastroenterology 12 (4) : 588-594. ScholarBank@NUS Repository ...
Introduction: Liver cirrhosis develops in about 10% of alcohol abusers. To date, a number of cells and cytokines have been identified, which are involved in induction of liver fibrotic processes. Nevertheless, the pathogenesis of liver cirrhosis has not been fully elucidated. The aim of the present study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. Materials and methods: The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. Results: The concentration of afamin was found to be significantly lower in patients with compensated
HBV related Liver disease is a common medical problem in China. An estimated 7.18% of the Chinese (about 93 million) is infected with hepatitis B, and most of the HBV- related hepatitis can developed into liver cirrhosis.. Liver transplantation is the only available life saving treatment for patients with end stage liver disease. However, lack of donors, surgical complications, rejection, and high cost are serious problems.. Mesenchymal stem cells (MSCs) possess plasticity and have the potential to differentiate into hepatocyte; Thus, MSCs hold great hope for therapeutic applications. Human umbilical cord-derived MSCs (hUC-MSCs) exhibit a more beneficial immunogenic profile and greater overall immunosuppressive potential than aged bone marrow-derived MSCs. Like MSCs derived from bone marrow, hUC-MSCs can also be used to treat rat liver fibrosis and improve glucose homeostasis in rats with liver cirrhosis. In this study, the patients with HBV-related liver cirrhosis will undergo administration of ...
TY - JOUR. T1 - Diabetes impacts prediction of cirrhosis and prognosis by non-invasive fibrosis models in non-alcoholic fatty liver disease. AU - Bertot, Luis C.. AU - Jeffrey, Gary P.. AU - de Boer, Bastiaan. AU - MacQuillan, Gerry. AU - Garas, George. AU - Chin, Justin. AU - Huang, Yi. AU - Adams, Leon A.. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) patients with diabetes are at increased risk of cirrhosis and liver-related death, and thus accurate fibrosis assessment in these patients is important. We examined the ability of non-invasive fibrosis models to determine cirrhosis and outcomes in NAFLD patients with and without diabetes. Methods: Non-alcoholic fatty liver disease patients diagnosed between 2006 and 2015 had Hepascore, NAFLD fibrosis score (NFS), APRI and FIB-4 scores calculated at baseline and were followed up for outcomes of overall and liver-related mortality/liver transplantation, hepatic decompensation and hepatocellular ...
BEVERLY, MA-(Marketwired - December 11, 2017) - BioVie Inc. (OTCQB: BIVI), a clinical-stage company focused on the development and commercialization of innovative drug therapies for liver disease, announced today that the US Food and Drug Administration (FDA) has granted Fast Track designation for BIV201 (continuous infusion terlipressin), the Companys patented Orphan drug candidate. BIV201 is currently being evaluated for the treatment of refractory ascites due to liver cirrhosis in a mid-stage (Phase 2a) US clinical trial, with 2 of the planned 6 patients having been treated with this therapy to date.. The FDAs Fast Track program is designed to facilitate development and expedite the review of drug candidates that are intended to treat serious or life-threatening conditions and demonstrate the potential to address unmet medical needs. Fast Track designation allows for more frequent communications with the FDA to discuss the clinical development program and review process. Upon submission of ...
The liver has a lot of blood vessels where blood from the intestines comes from. From there, the liver processes nutrients to make them usable and detoxifies toxins so the body can safely pass them to the kidneys or the large intestine.. Cirrhosis is basically the liver cells getting injured. Trauma can injure the liver, such as a knife stab or heavy impact, but it can recover relatively easily given the right treatment. Liver cirrhosis happens when the constant influx of toxins in the body injure the liver little by little. In order to keep damage from spreading, the body scars over the damage, just like a wound. If this happens long enough, the entire liver could be scarred to a point where it cant function anymore.. In some cases, liver cirrhosis is preceded by several other liver diseases like fatty liver and alcoholic hepatitis. Though on some individuals, liver cirrhosis happens without any prior diseases. ...
Abstract:. Ascites and hydrothorax are common complications of liver cirrhosis, however, unilateral isolated hepatic hydrothorax without associated ascites is an unusual and challenging complication of liver cirrhosis. Though rare, this condition often poses both diagnostic and therapeutic dilemma, especially in patients without other symptoms or risk factors for cirrhosis. It usually leads to prolonged hospitalization and may cause early mortality. Unilateral isolated hepatic hydrothorax may also be the only pointer to underlying cirrhosis in the absence of ascites. Liver transplantation remains the only definitive treatment for this condition.. ...
The present study analysed differences between the first decompensation in alcoholic vs. non-alcoholic liver cirrhosis, because the clinical management and prognosis of cirrhotic patients may differ according to aetiology and subsequent complications after hepatic decompensation.. Patients with alcoholic liver cirrhosis predominated in both investigated cohorts and were significantly younger than cases with non-alcoholic disease. These different baseline characteristics can be explained by several epidemiological and medical observations. Alcohol is the leading aetiology in several studies investigating the course of liver cirrhosis.[18, 19] In Saxony, up to 23% of the general population consume alcohol at a harmful level.[20] In contrast, the prevalence of chronic viral hepatitis B and C in Eastern parts of Germany is low, and significant lower than in matched control groups from Western Germany.[21, 22]. Medical reasons for the differences between baseline characteristics are the slow ...
Get complete cure for your Liver Cirrhosis Disease. At Astrokapoor, we provide Ayurveda Treatment for Liver Cirrhosis and are a trusted center for Liver Cirrhosis Treatment in Ayurveda. Contact Now: +91-9910095568
Get complete cure for your Liver Cirrhosis Disease. At Astrokapoor, we provide Ayurveda Treatment for Liver Cirrhosis and are a trusted center for Liver Cirrhosis Treatment in Ayurveda. Contact Now: +91-9910045568
Keywords: Hepatitis C Liver transplantation Sustained virological response Recurrent hepatitis C Transplantation results Intro Chronic hepatitis C disease (HCV) illness leading to decompensated liver cirrhosis or hepatocellular carcinoma is the main cause of orthotopic liver transplantation (OLT) worldwide. It is expected that the number of individuals with HCV illness referred for OLT will continue to increase in the next years in spite of improvements in antiviral therapy (1). Nonetheless if HCV viremia is present during the transplantation process the result is definitely common reinfection of liver allografts happening as early as the reperfusion phase of the surgical procedure with viral replication within hours after OLT (2 3 Recurrent liver disease due to HCV usually evolves after 3 months and is present in up to 70-90% of individuals 1 year after OLT. Furthermore the progression BEZ235 of recurrent disease is faster than in the immunocompetent human population (4 -7). Recurrent liver ...
BACKGROUND AND AIMS: The diagnosis of non-alcoholic steatohepatitis (NASH) and fibrosis staging are central to non-alcoholic fatty liver disease (NAFLD) assessment. We evaluated multi-parametric magnetic resonance (MR) in the assessment of NASH and fibrosis using histology as standard in NAFLD. METHODS: Seventy one patients with suspected NAFLD were recruited within one month of liver biopsy. MR data were used to define the liver inflammation and fibrosis score (LIF 0-4). Biopsies were assessed for steatosis, lobular inflammation, ballooning and fibrosis and classified as NASH or simple steatosis, and mild or significant (Activity ≥2 and / or Fibrosis ≥2 as defined by the Fatty Liver Inhibition of Progression consortium) NAFLD. Transient elastography (TE) was also performed. RESULTS: MR success rate was 95% vs 59% for TE (p|0.0001). Fibrosis stage on biopsy correlated with LIF (rs =0.51, p|0.0001). The area under the receiver operating curve (AUROC) using LIF for the diagnosis of cirrhosis was 0.85.
Hyaluronic acid (HA) serum levels correlate with the histological stages of liver fibrosis in hepatitis C virus (HCV) monoinfected patients, and HA alone has shown very good diagnostic accuracy as a non-invasive assessment of fibrosis and cirrhosis. The aim of this study was to evaluate serum HA levels as a simple non-invasive diagnostic test to predict hepatic fibrosis in HIV/HCV-coinfected patients and to compare its diagnostic performance with other previously published simple non-invasive indexes consisting of routine parameters (HGM-1, HGM-2, Forns, APRI, and FIB-4). We carried out a cross-sectional study on 201 patients who all underwent liver biopsies and had not previously received interferon therapy. Liver fibrosis was determined via METAVIR score. The diagnostic accuracy of HA was assessed by area under the receiver operating characteristic curves (AUROCs). The distribution of liver fibrosis in our cohort was 58.2% with significant fibrosis (F≥2), 31.8% with advanced fibrosis (F≥3), and 11
Liver stiffness measurement (LSM) can assess liver fibrosis in patients with chronic hepatitis B (CHB). We evaluated whether LSM can be used to assess changes in liver fibrosis during antiviral treatm
Advanced liver cirrhosis is associated with hyperdynamic circulation consisting of systemic hypotension, decreased peripheral resistance, and cardiac dysfunction, termed cirrhotic cardiomyopathy. Previous studies have revealed the role of endocannabinoids and vascular CB(1) receptors in the development of generalized hypotension and mesenteric vasodilation in animal models of liver cirrhosis, and CB(1) receptors have also been implicated in the decreased beta-adrenergic responsiveness of isolated heart tissue from cirrhotic rats. Here we document the cardiac contractile dysfunction in vivo in liver cirrhosis and explore the role of the endocannabinoid system in its development. Rats with CCl(4)-induced cirrhosis developed decreased cardiac contractility, as documented through the use of the Millar pressure-volume microcatheter system, low blood pressure, and tachycardia. Bolus intravenous injection of the CB(1) antagonist AM251 (3 mg/kg) acutely increased mean blood pressure, as well as both load
Background : The clotting is a multistep process comprised of sequence of events of platelet plug formation , clotting process , clotting process termination and clot removal .Synthesis of clotting factors and clearance of their activation products took place in liver. The magnitude of clinical features and coagulation abnormalities will vary depending on liver dysfunction . Therefore wide spectrum of abnormalities will be seen in patients of liver cirrhosis. Aims and Objectives : To study the various coagulation abnormalities in liver cirrhosis patients. Methodology : This 1 year prospective study was conducted in a tertiary hospital for the evaluation of the frequency of coagulation abnormalities in patients with cirrhosis of liver. 82 patients presenting with cirrhosis of liver were selected and were evaluated for coagulation profile. The data was collected via questionnaire form and analyzed by SPSS (Statistical Packages for Social Sciences) version The patients blood were tested for ...
Learn more about Liver Cirrhosis at Doctors Hospital of Augusta Related Terms: Alcoholic Liver Cirrhosis Biliary Cirrhosis Cirrhosis of the Liver Uses Principal...
Learn more about Liver Cirrhosis at Grand Strand Medical Center Related Terms: Alcoholic Liver Cirrhosis Biliary Cirrhosis Cirrhosis of the Liver Uses Principal...
Gurusamy K, Wilson P, Tsochatzis E. Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a network meta-analysis. Cochrane Database of Systematic Reviews 2018, Issue 9. Art. No.: CD013125. DOI: 10.1002/14651858. ...
Liver stiffness, measured by transient elastography (FibroScan), reflects not only fibrosis of the liver but also intrahepatic inflammation and portal hypertension. The diagnostic performance of FibroScan depends on the care and quality of the procedures used to measure liver stiffness. An experienced physician must interpret the liver stiffness measurement as a function of the clinical situation and other imaging and test results. Liver stiffness is strongly correlated with fibrosis of the liver during hepatitis, with co-infection by HCV (hepatitis C virus) and HIV (human immunodeficiency virus), with recurrence of HCV infection after liver transplantation, and with chronic cholestatic diseases. Liver stiffness is strongly correlated with the severity of portal hypertension and of cirrhosis. ...
Background: Vitamin D is required to maintain the integrity of the intestinal barrier and inhibits inflammatory signaling pathways. Objective: Vitamin D deficiency might be involved in cirrhosis-associated systemic inflammation and risk of hepatic decompensation in patients with liver cirrhosis. Methods: Outpatients of the Hepatology Unit of the University Hospital Frankfurt with advanced liver fibrosis and cirrhosis were prospectively enrolled. 25-hydroxyvitamin D (25(OH)D3) serum concentrations were quantified and associated with markers of systemic inflammation / intestinal bacterial translocation and hepatic decompensation. Results: A total of 338 patients with advanced liver fibrosis or cirrhosis were included. Of those, 51 patients (15%) were hospitalized due to hepatic decompensation during follow-up. Overall, 72 patients (21%) had severe vitamin D deficiency. However, patients receiving vitamin D supplements had significantly higher 25(OH)D3 serum levels compared to patients without ...
Food intake increases liver stiffness, but it is believed that liver stiffness returns to baseline two hours after a meal. The aim of this study was to investigate the impact of different sized meals on liver stiffness. Liver and spleen stiffness was measured with transient elastography (TE) and real-time 2-dimensional shear wave elastography (2D-SWE). Patients ingested a 625 kcal and a 1250 kcal liquid meal on two consecutive days. We measured liver and spleen elasticity, Controlled attenuation parameter (CAP) and portal flow at baseline and after 20, 40, 60, 120 and 180 minutes. Sixty patients participated, 83% with alcoholic liver disease. Twenty-eight patients had METAVIR fibrosis score F0-3 and 32 patients had cirrhosis. Liver stiffness, spleen stiffness and CAP increased after both meals for all stages of fibrosis. False positive 2D-SWE liver stiffness measurements caused 36% and 52% of patients with F0-3 fibrosis to be misclassified with higher stages of fibrosis after the moderate and high
Washington D.C., Feb. 2(ANI): A recent review has linked regular consumption of coffee with a reduced risk of liver cirrhosis.. In patients with cirrhosis, the liver becomes scarred often as a result of long-term and persistent injury from toxins like alcohol and viruses like hepatitis C. It can be fatal because it increases the risk of liver failure and cancer.. The analysis conducted by Wiley found that an extra 2 cups of coffee per day may reduce the risk of cirrhosis by 44 per cent and it may nearly halve the risk of dying from cirrhosis.. Lead author Dr. O. J. Kennedy said that coffee appeared to protect against cirrhosis and their research could be an important finding for patients at risk of cirrhosis to help to improve their health outcomes.. Kennedy added that they now need robust clinical trials to investigate the wider benefits and harms of coffee so that doctors can make specific recommendations to patients.. The research is published in the journal Alimentary Pharmacology and ...
BACKGROUND: There is limited data on the nutritional status of Asian patients with various aetiologies of cirrhosis. This study aimed to determine the prevalence of malnutrition and to compare nutritional differences between various aetiologies.. METHODOLOGY: A cross-sectional study of adult patients with decompensated cirrhosis was conducted. Nutritional status was assessed using standard anthropometry, serum visceral proteins and subjective global assessment (SGA). RESULTS: Thirty six patients (mean age 59.8 +/- 12.8 years; 66.7% males; 41.6% viral hepatitis; Child-Pugh C 55.6%) with decompensated cirrhosis were recruited. Malnutrition was prevalent in 18 (50%) patients and the mean caloric intake was low at 15.2 kcal/kg/day. SGA grade C, as compared to SGA grade B, demonstrated significantly lower anthropometric values in males (BMI 18.1 +/- 1.6 vs 26.3 +/- 3.5 kg/m2, p < 0.0001; MAMC 19.4 +/- 1.5 vs 24.5 +/- 3.6 cm, p = 0.002) and females (BMI 19.4 +/- 2.7 vs 28.9 +/- 4.3, p = 0.001; MAMC ...
TY - JOUR. T1 - Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels. AU - and the NASH Clinical Research Network. AU - Gawrieh, Samer. AU - Wilson, Laura. AU - Cummings, Oscar W.. AU - Clark, Jeanne. AU - Loomba, Rohit. AU - Hameed, Bilal. AU - Abdelmalek, Manal F.. AU - Dasarathy, Srinivasan. AU - Neuschwander-Tetri, Brent A.. AU - Kowdley, Kris. AU - Kleiner, David. AU - Doo, Edward. AU - Tonascia, James A. AU - Sanyal, Arun. AU - Chalasani, Naga. PY - 2019/10/1. Y1 - 2019/10/1. N2 - OBJECTIVES: Patients with nonalcoholic fatty liver disease (NAFLD) and normal aminotransferase levels may have advanced liver histology. We conducted a study to characterize the prevalence of and factors associated with advanced liver histology in patients with histologically characterized NAFLD and normal aminotransferase levels. METHODS: We evaluated 534 adults with biopsy-proven NAFLD and alanine aminotransferase (ALT) ...
BACKGROUND AND AIMS: Diagnosis of liver fibrosis by transient elastography (Fibroscan) is a new and non-invasive method. We report its results, and compare them with the non-invasive biological tests. RESULTS: Fibroscan is validated for chronic hepatitis C, allowing to diagnose the fibrosis (Metavir) F2, F3 and F4 with areas under the ROC curve of 0.79-0.83, 0.90-0.91 and 0.91-0.97 respectively. The non-invasive diagnosis of the cirrhosis can be made with positive and negative predictive values from 70 to 95% and 77 in 95%. Preliminary data concern the HCV-HIV co-infections, primary biliary cirrhosis, NASH, portal hypertension, and the follow-up of the hepatic fibrosis. These results are altogether comparable to the various non-invasive biological tests, for cirrhosis diagnosis. CONCLUSIONS: Its remain to determine the respective places of Fibroscan and non-invasive biological tests, in the liver fibrosis diagnosis. ...
The RESIST-HCV study followed the clinical outcomes of all people treated with direct-acting antivirals in Sicily between March 2015 and December 2016. The study excluded people with a prior history of hepatocellular carcinoma or liver transplant. A total of 4668 people were included in the analysis, 69.2% with Child-Pugh A cirrhosis (compensated), 8.8% with Child-Pugh B cirrhosis and 22% with chronic infection. Genotype 1b infection predominated (68%). The mean age of people with cirrhosis and people without cirrhosis was 66 years and 62 years respectively. Fifty-eight per cent were male. Liver stiffness measurements by Fibroscan showed a mean liver stiffness of 10 kPA in people with chronic infection, 21.8 kPA in people with Child-Pugh A and 27.3 kPA in people with Child-Pugh B.. Intent-to-treat analysis showed that the overall rate of sustained virologic response (cure) was 90.7% (93.1% in the chronic hepatitis group, 90.9% in the Child-Pugh A group and 83.1% in the Child-Pugh B group). ...
Looking for online definition of Child-Pugh score in the Medical Dictionary? Child-Pugh score explanation free. What is Child-Pugh score? Meaning of Child-Pugh score medical term. What does Child-Pugh score mean?
These data showed cardiac contractile impairment in cirrhosis, associated with altered beta-adrenergic receptor signaling function and guanine nucleotide-binding protein expression. These factors may play an important role in the pathogenesis of cirrhotic cardiomyopathy.
Why this is important:- Observational studies reported that up to 10% of children and young people diagnosed with NAFLD progress to advanced liver fibrosis and are at risk of developing advanced stages of liver disease. Pharmacological treatment (for example, pioglitazone or vitamin E) could prevent progression to advanced liver fibrosis or end-stage liver disease, as has been reported in a number of high quality studies in adults with confirmed NAFLD. There are insufficient data on the efficacy of similar pharmacological treatment in children and young people with NAFLD to make clear treatment recommendations. ...
Key benefits of the report:. 1. Advanced Liver Cancer market report covers a descriptive overview and comprehensive insight of the Advanced Liver Cancer epidemiology and Advanced Liver Cancer market in the 7 MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan.). 2. Advanced Liver Cancer market report provides insights on the current and emerging therapies.. 3. Advanced Liver Cancer market report provides a global historical and forecasted market covering drug outreach in 7 MM.. 4. Advanced Liver Cancer market report offers an edge that will help in developing business strategies by understanding trends shaping and driving the Advanced Liver Cancer market.. Request for sample pages: https://www.delveinsight.com/sample-request/advanced-liver-cancer-market. Advanced Liver Cancer: Overview. Advanced Liver Cancer is a stage IV Liver Cancer in which the cancer has spread to nearby lymph nodes and may have grown into nearby blood vessels or organs. It does not often metastasize but ...
We report here two cases of hepatocellular carcinoma (HCC) 90 and 70 months, respectively, after successful treatment with interferon (IFN) and ribavirin for hepatitis C virus (HCV)-related cirrhosis. A 50-year-old Caucasian man and a 66-year-old Caucasian woman with HCV-related cirrhosis were treated with IFN and ribavirin and in both cases a sustained virological response (SVR) was obtained with persistent normalization of serum aminotransferases and continuous disappearance of serum HCV-RNA. Both patients were subsequently followed up within an HCC surveillance programme based on biochemical and ultrasound (US) evaluation every 6 months and the appearance of HCC was detected 90 and 70 months, respectively, after discontinuation of therapy. We introduce these two cases to call attention to the importance of not underestimating the risk of HCC development even many years after complete HCV eradication, especially in the presence of established cirrhosis and concomitance of other risk factors ...
Liver Gross Specimens. Submassive hepatic necrosis with early postnecrotic cirrhosis. Comment: Nodular lesions represent attempt at regeneration. COMMENT ON SPECIMENS (#25-29): These illustrate the range of changes seen in autopsy livers from patients dying from viral hepatitis (liver disease or complications therefrom): #25=a liver that is bile stained and shows dark areas of necrosis but is not as massively necrotic as #26 and #27 (these two livers probably less than 800-900 gms) and although these two do not now show the usual maroon appearance, there has been a marked loss of hepatocytes. #28 and #29 show pale nodular areas interspersed in liver parenchyma which histologically demonstrates, besides necrosis, scarring or cirrhosis (#28 less, #29 more scarring). The nodular areas actually represent attempts at regeneration of hepatocytes ...
Ascites is a major complication of decompensated liver cirrhosis. Intraabdominal hypertension and structural alterations of parenchyma involve decisive changes in hepatosplanchnic blood flow. Clearance of indo-cyanine green (ICG) is mainly dependent on hepatic perfusion and hepatocellular function. As a consequence, plasma disappearance rate of ICG (ICG-PDR) is rated as a useful dynamic parameter of liver function. This study primarily evaluates the impact of large-volume paracentesis (LVP) on ICG-PDR in critically ill patients with decompensated cirrhosis. Additionally, it describes influences on intraabdominal pressure (IAP), abdominal perfusion pressure (APP), hepatic blood flow, hemodynamic and respiratory function. We analyzed LVP in 22 patients with decompensated liver cirrhosis. ICG-PDR was assessed by using noninvasive LiMON technology (Pulsion® Medical Systems; Maquet Getinge Group), and hepatic blood flow was analyzed by color-coded duplex sonography. Paracentesis of a median volume of 3450
TY - JOUR. T1 - Elevated serum dipeptidyl peptidase IV (CD26, EC 3.4.14.5) activity in experimental liver cirrhosis. AU - Lakatos, AU - Firneisz, AU - Borcsiczky, AU - Zalatnai, AU - Selmeci, AU - Szalay, PY - 2000/9/25. Y1 - 2000/9/25. N2 - Background: Dipeptidyl peptidase IV (DPP IV) is a cell surface ectoenzyme widely distributed in the rat body, present on the epithelial cells of the brush border membranes (e.g. bile canaliculi) and on the surface of reactive lymphocytes and fibroblasts. DPP IV has been implicated in hepatocyte-extracellular matrix interactions, fibroblast activation and proliferation and in T-cell activation. Aberrant DPP IV expression was found in human liver cirrhosis, and elevated serum DPP IV activity was reported in patients with primary biliary cirrhosis and chronic hepatitis C virus infection. The aim of the study was to examine serum DPP IV activity in experimental liver cirrhosis. Methods: Liver cirrhosis was induced by administering diethyl-nitrosamine, ...
TY - JOUR. T1 - Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation. AU - Gawrieh, Samer. AU - Papouchado, Bettina G.. AU - Burgart, Lawrence J.. AU - Kobayashi, Shogo. AU - Charlton, Michael R.. AU - Gores, Gregory J.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - Only a subset of hepatitis C virus (HCV)-infected patients develop progressive hepatic fibrosis after liver transplantation (LT). Hepatic stellate cell (HSC) activation is a pivotal step in hepatic fibrosis and precedes clinically apparent fibrosis. We determined whether early HSC activation, measured in 4-month protocol post-LT biopsies, is predictive of subsequent development of more histologically severe recurrence of HCV. Early (4 month) post-LT HSC activation, as measured by α-smooth muscle actin (α-SMA) staining, was determined in liver biopsies from recipients with severe (fibrosis score ≥ 2, n = 13) and with mild (fibrosis score of 0, n = 13) recurrence of HCV at one-year ...
Manuscript Accepted: 16 SEP 2013. Keywords: HBV; inactive carriers; metabolic syndrome; fibrosis; FibroScan. Abstract\. Background and Aim. There are few data of fibrosis development in chronic hepatitis B (CHB) patients classified as inactive carriers. The aim of this study is to determinate the prevalence of significant fibrosis and probable cirrhosis measured by FibroScan in real inactive CHB carriers and investigate the relationship with virological, epidemiological and metabolic factors.. Methods. Cross-sectional cohort study including CHB inactive carriers. Liver stiffness measurement was performed with transient elastography (FibroScan). Significant fibrosis (≥F2) was defined as stiffness ,7.5 kPa, and probable cirrhosis as ,11.8 kPa. Factors associated with significant fibrosis were explored with univariate and multivariate adjusted logistic regression analyses.. Results. 96 CHB inactive carriers were analyzed. Of them, 24 (25%) had significant fibrosis and 7 (7%) probable cirrhosis; ...
Looking for information on Congenital hepatic fibrosis? Medigest has all you need to know about Congenital hepatic fibrosis - Symptoms and Signs, Causes, Treatments and definition
TY - JOUR. T1 - Comparison of Circulating Endothelial Cell/Platelet Count Ratio to Aspartate Transaminase/Platelet Ratio Index for Identifying Patients with Cirrhosis. AU - Sethi, Saurabh. AU - Simonetto, Douglas. AU - Abdelmoneim, Soha S.. AU - Campion, Michael B.. AU - Kaloiani, Irakli. AU - Clayton, Amy C.. AU - Kremers, Walter K. AU - Halling, Kevin C.. AU - Kamath, Patrick Sequeira. AU - Talwalkar, Jayant. AU - Shah, Vijay. PY - 2012. Y1 - 2012. N2 - Background/Objectives: Circulating endothelial cells (CECs) are indicative of vascular injury and correlate with severity of vascular diseases. A pilot study showed that the ratio of CEC to platelet count (CEC/PC) was effective in predicting cirrhosis. Therefore, we evaluated CEC/PC in a larger cohort of patients, correlated it with cirrhosis, and compared its operating characteristics with previously described biomarker for cirrhosis, the AST/platelet ratio index (APRI). Methods: Fifty-three patients with cirrhosis, 20 matched healthy ...
This study was performed to systematically evaluate the accuracy of magnetic resonance elastography (MRE) in staging of liver fibrosis in non-alcoholic fatty liver disease (NAFLD). PUBMED, EMBASE, Web of Science, CNKI, Cochrane Library database were searched from January 2008 to December 2018 for studies related to MRE in the diagnosis of NAFLD liver fibrosis. The quality of the included literature was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The pooled sensitivity, the pooled specificity, and area under the receiver operating characteristic curve (AUROC) value was performed by STATA 14.0 software. A total of 12 studies were included, involving 910 patients. The pooled sensitivity and specificity of each group were 0.77 (95%CI 0.69-0.83) and 0.90 (95%CI 0.83-0.94) for F ≥ 1 (mild liver fibrosis), 0.87 (95%CI 0.74-0.94) and 0.86 (95%CI 0.71-0.94) for F ≥ 2 (significant liver fibrosis), 0.89 (95%CI 0.81-0.94) and 0.84 (95%CI 0.63-0.94) for F ≥ 3(severe liver
BACKGROUND: Transient elastography (TE) is widely used for non-invasive assessment of liver fibrosis in HIV-HCV co-infected patients. TE, however, cannot determine liver morphology. Acoustic radiation force impulse (ARFI) imaging is a novel procedure enabling assessment of liver fibrosis during a conventional ultrasonographic examination. This study evaluated the correlation between liver fibrosis measurements by TE and ARFI. METHODS: Each of 46 HIV-HCV patients underwent both ARFI and TE within 6 months. Patients were evaluated by the equivalent METAVIR scoring system, using previously established cut-off values. Agreements between the ARFI and TE scores were estimated by Kappa coefficients, with Kappa values ≥0.40, ≥0.60, and ≥0.80 defined as moderate, good and very good agreement, respectively. RESULTS: ARFI and TE yielded Equivalent Metavir fibrosis scores of F1 in 26 and 31 patients, respectively; F2 in nine and seven, respectively; F3 in three and two, respectively; and F4 in eight and
Cholestatic liver diseases including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and alcoholic-induced hepatobiliary damage are growing problems in the United States as well as worldwide. There are no successful treatments for these diseases that ultimately develop into cirrhosis and end stage liver diseases with no treatment but liver transplantation. We used the cholestatic bile-duct ligated (BDL) mouse liver to examine treatment with small or large cholangiocytes, a mouse model that mimics some features of PSC to study treatment with stem cell-derived extracellular vesicles and a mouse model of alcoholic liver disease to show the important role of let-7. After treatment, liver tissues/cells were analyzed for fibrosis, inflammation, endodermal markers and hepatic stellate cell activation. Mechanisms of action were evaluated further in vitro through the use of hepatic cell lines. We showed that small cholangiocyte treatment reduced fibrosis, biliary mass and stellate ...
Selecting a marginal donor in liver transplantation (LT) remains controversial but is necessary because of the small number of available donors. A 46-year-old Japanese woman was a candidate to donate her liver to her brother, who had decompensated liver cirrhosis of unknown origin. Eight years before the donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C virus (HCV) infection (serotype 2). She had received anti-viral therapy with interferon α-2b three times weekly for 24 weeks and had a sustained viral response (SVR). A biopsy of her liver before the donation showed normal findings without any active hepatitis, and her serum was negative for HCV-RNA. Only 67 patients have undergone LT from a cadaveric donor in Japan. The family in this case decided to have living donor LT. A careful selection for the liver graft donation was made; however, since she was the only candidate, we approved her as a living donor. She was discharged nine days after the liver donation. Her liver
TY - JOUR. T1 - Effects of some food components on non-alcoholic fatty liver disease severity. T2 - Results from a cross-sectional study. AU - Mirizzi, Antonella. AU - Franco, Isabella. AU - Leone, Carla Maria. AU - Bonfiglio, Caterina. AU - Cozzolongo, Raffaele. AU - Notarnicola, Maria. AU - Giannuzzi, Vito. AU - Tutino, Valeria. AU - De Nunzio, Valentina. AU - Bruno, Irene. AU - Buongiorno, Claudia. AU - Campanella, Angelo. AU - Deflorio, Valentina. AU - Pascale, Annamaria. AU - Procino, Filippo. AU - Sorino, Paolo. AU - Osella, Alberto Rubén. PY - 2019/11. Y1 - 2019/11. N2 - Background: The high prevalence of non-alcoholic fatty liver disease (NAFLD) observed in Western countries is due to the concurrent epidemics of overweight/obesity and associated metabolic complications, both recognized risk factors. A Western dietary pattern has been associated with weight gain and obesity, and more recently with NAFLD. Methods: This is a baseline cross-sectional analysis of 136 subjects (79 males) ...
The Prevalence and Causative Bacteria of Spontaneous Bacterial Peritonitis in Patients with Ascites Due to Liver Cirrhosis Mostafa M. Ragheb* Hassan Nasr El
The level and profiles of blood free carnitine and acylcarnitines, obtained by acylcarnitine analysis using tandem mass spectrometry, reflect various metabolic conditions. We aimed to examine the level of free carnitine and acylcarnitines in liver cirrhosis patients by acylcarnitine analysis and determine the clinical and subjective factors associated with blood carnitine fraction levels in liver cirrhosis. We compared blood carnitine fractions in 54 liver cirrhotic patients to other laboratory test results and questionnaire answers. In almost all patients, the blood levels of free carnitine (C0) and acetylcarnitine (C2) were within the normal reference range. However, in some patients, the levels of long-chain acylcarnitines, such as C16 and C18:1-acylcarnitine, were higher than the normal reference range. Liver function, assessed by Child-Pugh score, was significantly correlated with the blood level of each carnitine fraction measured (C0, C2, C3, C4, C6, C10, C12, C12:1, C14:1, C16, C18:1, and C18:2
The main objectives of this study were to define the occurrence and levels of hepatitis B virus (HBV) DNA in asymptomatic HBV carriers, cirrhosis patients and hepatocellular carcinoma (HCC) cases from The Gambia, and to evaluate the risk for cirrhosis or HCC associated with HBV viremia. We used sensitive real-time quantitative PCR assays to measure HBV DNA in samples from a case-control study consisting of 60 asymptomatic HBV carriers, 53 cirrhotic patients and 129 HCC cases. Logistic regression was used to estimate the risks of cirrhosis and HCC associated with HBV-DNA levels and HBV e antigenemia (HBeAg) detection (a surrogate marker for viral replication). Detectable HBV viremia and HBeAg positivity were both significantly associated with cirrhosis (increasing risk by fourfold and 11-fold respectively) and with HCC (increasing risk by sixfold and threefold respectively). HBV-DNA levels were significantly higher in both HCC cases and cirrhotic patients compared to asymptomatic carriers (P | 0.01 for
TY - JOUR. T1 - Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis. T2 - a network meta-analysis. AU - Komolafe, Oluyemi. AU - Roberts, Danielle. AU - Freeman, Suzanne C. AU - Wilson, Peter. AU - Sutton, Alex J. AU - Cooper, Nicola J. AU - Pavlov, Chavdar S. AU - Milne, Elisabeth Jane. AU - Hawkins, Neil. AU - Cowlin, Maxine. AU - Thorburn, Douglas. AU - Davidson, Brian R. AU - Tsochatzis, Emmanuel. AU - Gurusamy, Kurinchi Selvan. N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.. PY - 2020/1/16. Y1 - 2020/1/16. N2 - ...
Objectives: A non-invasive, simple and non-expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C. Aim: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC). Methods: The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow-up with outcome: liver-related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology. Results: We found that the AST/ALT ratio was significantly higher in cirrhotic patients than in non-cirrhotic patients. A high AST/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis. Conclusion: The AST/ALT ratio seems to be of clinical value ...
Liver cirrhosis is associated with significant nutritional risks that often result in serious hepatic complications and poor survival rates. Diet is an important but underutilized aspect in the treatment modality of cirrhosis. Therefore, the aims of this review are to ascertain nutritional risks associated with its pathophysiology and to summarize existing evidence that support dietary recommendations for managing this patient population. Alterations in substrate utilization for energy production is a main feature of liver cirrhosis, resulting in increased catabolism of protein stores and a predisposition toward protein-energy malnutrition, even in the early stages of the disease. The body of evidence suggests that a high energy and protein (,1.2 g/kg body weight/d) diet consumed frequently and late in the evening is effective in improving nutritional status of these patients and has been associated with improved hospitalization and mortality rates. The use of branched-chain amino acid ...
Chronic liver disease in the clinical context is a disease process of the liver that involves a process of progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis. Chronic liver disease refers to disease of the liver which lasts over a period of six months. It consists of a wide range of liver pathologies which include inflammation (chronic hepatitis), liver cirrhosis, and hepatocellular carcinoma. The entire spectrum need not be experienced. Signs of chronic liver disease detectable on clinical examination can be divided into those that are associated with the diagnosis of chronic liver disease, associated with decompensation and associated with the cause. Nail clubbing Palmar erythema Spider nevi (angiomata) Gynaecomastia Feminising hair distribution Testicular atrophy Small irregular shrunken liver Anaemia Caput medusae Drowsiness (encephalopathy) Hyperventilation (encephalopathy) Metabolic flap/asterixis (encephalopathy) Jaundice (excretory ...
A new study by German researchers found that a variation in the PNPLA3 (adiponutrin) gene was associated with cirrhosis of the liver and elevated transaminase (liver enzyme) levels in alcoholic Caucasians. The risk of cirrhosis in alcoholics in the genetic high risk group might be as high as 25 to 50%. Full findings are published in the January 2011 issue of Hepatology, a journal of the American Association for the Study of Liver Diseases. Alcoholic liver disease (ALD)-ranging from alcoholic fatty liver to alcohol induced liver fibrosis and cirrhosis-accounts for more than 50% all chronic liver disease in industrialized countries and was responsible for over 25,000 deaths in the U.S. alone in 2005. Studies have shown that while all heavy drinkers display signs of hepatitis steatosis (fatty liver), only 10% to 35% of alcoholics develop hepatic inflammation, with up to 20% progressing to cirrhosis. Further medical evidence suggests a link between PNPLA3 gene variation and liver fat content; ...
Title:IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression. VOLUME: 16 ISSUE: 12. Author(s):Daniel A Giles, Maria E Moreno-Fernandez and Senad Divanovic. Affiliation:Division of Immunobiology Cincinnati Childrens Hospital Medical Center TCHRF - Location S, Room #S.5.409 3333 Burnet Avenue Cincinnati, Ohio 45229-3039 U.S.A.. Keywords:IL-17, Inflammation, NAFLD, Obesity.. Abstract:Obesity is a primary risk factor for the development of non-alcoholic fatty liver disease (NAFLD). NAFLD, the most common chronic liver disease in the world, represents a spectrum of disorders that range from steatosis (NAFL) to steatohepatitis (NASH) to cirrhosis. It is anticipated that NAFLD will soon surpass chronic hepatitis C infection as the leading cause for needing liver transplantation. Despite its clinical and public health significance no specific therapies are available. Although the etiology of NAFLD is multifactorial and remains largely enigmatic, it is well accepted that ...
Background amp; Aims: Non-alcoholic fatty liver disease (NAFLD) is very common in the general population, but identifying patients with increased risk of mortality and liver-specific morbidity remains a challenge. Non-alcoholic steatohepatitis (NASH) is thought to enhance this risk; therefore, resolution of NASH is a major endpoint in current pharmacologic studies. Herein, we aim to investigate the long-term prognosis of a large cohort of NAFLD patients, and to study the specific effect of NASH and fibrosis stage on prognosis. Methods: We conducted a retrospective cohort study of 646 biopsy-proven NAFLD patients. Each case was matched for age, sex and municipality to ten controls. Outcomes on mortality and severe liver disease, defined as cirrhosis, liver decompensation/failure or hepatocellular carcinoma, were evaluated using population-based registers. Cox regression models adjusted for age, sex and type 2 diabetes were used to examine the long-term risk according to fibrosis stage. Likelihood ...
Together we, the couple were called upon by the doctors regarding my liver disease. Doctor took both of us in a conference room and told about the alarming stage of liver cirrhosis. They put an option to arrange Rs. 50 Lakh along with a deadline. If I wish to survive I had to arrange that hard target. When we got out of the hospital my wife notified me that she had gone through an advertisement in a newspaper about modern homoeopathic treatment of liver cirrhosis. Treatment was assured as 90% liver failure cases were significantly recovered. As I was hospitalized, allowed my wife to visit Modern Homoeopathy. Amid strong hopes my wife took an appointment and waited for hours. Before her turn she had a discussion with other patients and their relatives about Modern Homoeopathy and its results. Finally she was called upon in the consulting room. Dr. Vijaykumar Mane carefully went through my all reports. My wife was in stress. After some time Dr. Mane with a smile on his face looked at my wife and ...
Bleeding in the digestive tract and brain dysfunction induced by painkillers or sedatives (drug-induced toxic encephalopathy) were identified as further trigger, although at a lower rate. Lead investigator Professor Jonel Trebicka, gastroenterologist and hepatologist at the Medical Clinic I of the University Hospital Frankfurt, explains: The acute decompensation of liver cirrhosis demands rapid and targeted action. In the PREDICT study, we therefore want to learn a lot about the triggering factors of this life-threatening disease in order to be able to derive recommendations for diagnostics and therapy. Knowing what the most likely triggers of acute decompensation are will help to further develop diagnostic and treatment strategies for patients with this life-threatening disease.. ###. The pan-European PREDICT study has monitored the clinical course of acute decompensations of liver cirrhosis to find early signs of the development of acute-on-chronic liver failure (ACLF). PREDICT is funded by ...
Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate cells (HSCs) in vitro and in a mouse model of liver fibrosis. LX2, an immortalized human HSC line, was cultured and treated with GGA at concentrations up to 0.5 mM. After GGA treatment, changes in cellular morphology, apoptosis, and fibrosis-related gene expression were assessed. Male C57BL/6 J mouse model of carbon tetrachloride (CCl4)-induced liver fibrosis was treated with GGA. Liver fibrosis was evaluated using Sirius red staining and immunohistochemistry for α-smooth muscle actin (SMA). GGA decreased the density of LX2 and primary human hepatic stellate cells but not that of HepG2 cells (a human hepatoma cell line), which was employed as control. In addition, GGA decreased the expression of fibrogenic genes and increased that of C/EBP homologous protein (CHOP). It also induced endoplasmic
Purpose: Benzodiazepines (BDZs) are the drugs of choice to prevent the symptoms of alcohol withdrawal syndrome (AWS). Various treatment protocols are published and have been shown to be effective in both office-managed and facility-managed treatment of AWS. The aim of this scientific commentary is to demonstrate the differences in the expected exposure to BDZs during AWS treatment using different treatment regimens available in the literature, in patients with or without alcoholic liver cirrhosis.. Methods: Diazepam and lorazepam AWS protocols were examined and reviewed in the literature, and blood plasma levels were examined and compared, respectively.. Results: Considerable variation in the blood levels with the different dosing schedules was found. Because the drugs are metabolized differently, we have also shown that liver disease affects the blood levels of diazepam, but not of lorazepam.. Conclusions: Differences in treatment regimens, the choice of BDZ, as well as the presence of liver ...
Liver cirrhosis portal hypertension patients to reduce the number of blood cells are common in clinical, and often affect the prognosis. This paper discusses cirrhotic portal hypertension patients complicated by the reason of the decrease in the number of peripheral blood cells and what is the clinical significance of these reasons so as to provide theoretical support for the choice of treatment. Splenomegaly and hypersplenism caused should be the main reason for reducing the number of blood cells, but not all, other reasons are alcohol and virus inhibition of bone marrow, liver function impairment, autoimmune damage and loss of blood, etc. If it is a function of the spleen hyperfunction caused by blood cells decreases, blood should rise to normal after splenectomy, or consider other reason or there are other reasons at the same time.
Liver fibrosis is a feature in the majority of chronic liver diseases and oxidative stress is considered to be its main pathogenic mechanism. Antioxidants including vitamin E, are effective in preventing liver fibrogenesis. Several plant-drived antioxidants, such as silymarin, baicalin, beicalein, quercetin, apigenin, were shown to interfere with liver fibrogenesis. The antioxidans above are polyphenols, flavonoids or structurally related compounds which are the main chemical components of Pomegranate peels and seeds, and the antioxidant activity of Pomegranate peels and seeds have been verified. Here we investigated whether the extracts of pomegranate peels (EPP) and seeds (EPS) have preventive efficacy on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and explored its possible mechanisms. The animal model was established by injection with 50 % CCl4 subcutaneously in male wistar rats twice a week for four weeks. Meanwhile, EPP and EPS were administered orally every day for 4 weeks,
Background: Spontaneous ascitic fluid infection (SAI) is an acute infection of ascitic fluid. SAI has three subtypes; SBP, CNNA, MNB. The prototype is Spontaneous bacterial peritonitis (SBP). SBP is a frequent and serious complication in patients with cirrhosis leading to significant mortality and morbidity. Diagnosis of SBP is mainly established by elevated polymorphonuclear leukocyte count and positive ascitic fluid bacterial culture. Methodology: Records of patients with suspected diagnosis of Spontaneous ascitic fluid infection were analyzed in the present study. Patients admitted in the last one year i.e., between January 2014 to December 2014 with ascites secondary to cirrhosis were included. All patients with decompensated cirrhosis had undergone ascitic fluid paracenetesis after admission to the hospital. Ascitic fluid was centrifuged and analyzed for Total protein, Albumin, Total and Differential leukocyte count. Ascitic fluid was cultured by using BacTec method to determine the growth ...
A prospective study was undertaken to determine the frequency of peptic ulceration in different forms of chronic liver disease and the effect of corticosteroid treatment. One hundred sixty-three patients with chronic liver disease underwent upper gastrointestinal endoscopy, 106 for investigation of dyspeptic symptoms and the remaining 57 for assessment of the presence of varices. Twenty-four peptic ulcers were found (14.7%), 12 duodenal, 8 gastric, and 4 prepyloric. Ulcers were found in 5 of 15 patients with hepatitis B surface-antigen-positive chronic active liver disease (33%), 10 of 46 patients with alcoholic liver disease (22%), 5 of 35 with primary biliary cirrhosis (14%), 2 of 19 with miscellaneous chronic liver diseases (10%), and 2 of 25 with cryptogenic cirrhosis (8%). Ulcers were not demonstrated in any of the 23 patients with hepatitis B surface-antigen-negative chronic active hepatitis. Thirty-one patients were receiving prednisolone therapy, 5 had peptic ulcer compared with 19 of ...
The availability of direct-acting antiviral agents (DAA) regimens has expanded the pool of patients eligible for treatment. However, data on the virologic response and tolerability of DAAs in elderly patients are lacking. We evaluated the efficacy and safety of DAAs in patients with advanced fibrosis/cirrhosis in real-life practice with the focus on those aged ≥65 years. Between January and December 2015, all consecutive patients with HCV-related advanced fibrosis/cirrhosis treated with DAA at eleven tertiary referral centres in Emilia Romagna (Italy) were enrolled. Regimen choice was based on viral genotype and stage of disease, according to guidelines. The primary end point was sustained virologic response 12 weeks after the end of treatment (SVR12). Overall, 282 of 556 (50.7%) patients evaluated were elderly, most of them with cirrhosis. Antiviral therapy was stopped prematurely in four (1.4%) patients. Two patients, both with cirrhosis, died during treatment due to worsening of liver/renal ...
Duvoux, C.; Pawlotsky, J.M.; Cherqui, D.; Metreau, J.M.; Fagniez, P.L.; Duval, J.; Dhumeaux, D., 1994: Value of HCV RNA quantitation in diagnosis of acute graft dysfunction after liver transplantation for HCV-related cirrhosis
Low Calorie Ottled Alcoholic Beverages But thankfully, if youre partaking in Dry January, or want to scale back on your drinking, there are plenty of low alcohol and alcohol-free drinks from noseccos. amazon.co.uk Boasting just 53. The producer of Swedish cider brand Kopparberg has launched an alcohol-infused sparkling water brand in the UKs retail sector to capitalise on the growth. Your diet can play a much significant role in your liver health than previously. supplements and taking hormone replacement therapy have also emerged as potential therapies for muscle wasting.. it has no treatment. This marks cirrhosis among those diseases with the greatest unmet medical needs. Healthy liver, left, versus cirrhotic liver, right (source). Cirrhosis can have many causes,. leading to cirrhosis and liver failure. Diet and other lifestyle changes can often improve symptoms and reduce your risk of complications. Autoimmune conditions involve your immune system mistakenly.. . for oralization during ...
TY - JOUR. T1 - Characterising the risk interplay between alcohol intake and body mass index on cirrhosis morbidity. AU - Innes, Hamish. AU - Crooks, Colin J.. AU - Aspinall, Esther. AU - Card, Tim R.. AU - Hamill, Victoria. AU - Dillon, John. AU - Guha, Neil I.. AU - Hayes, Peter C.. AU - Hutchinson, Sharon. AU - West, Joe. AU - Morling, Joanne R.. N1 - This article is protected by copyright. All rights reserved.. PY - 2021/8/28. Y1 - 2021/8/28. N2 - Background & Aims: It is thought that alcohol intake and BMI interact supra-additively to modulate the risk of cirrhosis; but evidence for this phenomenon is limited. We investigated the interrelationship between alcohol and BMI on the incidence of cirrhosis morbidity for participants of the United Kingdom Biobank study (UKB) study.Approach & Results: The primary outcome was the cumulative incidence of cirrhosis morbidity, defined as a first-time hospital admission for cirrhosis (with non-cirrhosis mortality incorporated as a competing risk). All ...
Background It is estimated that up to 5% of inflammatory bowel disease (IBD) patients have clinically significant liver disease due to multifactorial causes such as underlying Primary Sclerosing Cholangitis, pharmacotherapy, fatty liver disease or nodular regenerative hyperplasia. In recent years, transient elastography (TE), which uses the sonic detection of liver stiffness to predict hepatic fibrosis has increasingly replaced the need for a liver biopsy. It has been validated in patients with chronic hepatitis C as an accurate non-invasive predictor of advance fi brosis and cirrhosis. Aims Our aim was to evaluate the prevalence of clinically significant liver disease in IBD patients as defi ned by an increased liver stiffness measurement (LSM) using Transient Elastography (FibroScan®). Methods 110 random IBD patients and 55 non-IBD control patients (composed of patient relatives and hospital staff) had their LSM recorded. The median reading in kilopascals (kPa) of 10 successful acquisitions ...
Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis : A preliminary, prospective, open-label ...
To detect potentially curable cases of hepatocellular carcinoma, outpatients with chronic hepatitis or compensated liver cirrhosis who were seen at the Center for Adult Diseases (Osaka, Japan) were examined periodically by means of ultrasonography and measurement of serum alpha-fetoprotein. Risk factors for hepatocellular carcinoma were identified with a Cox proportional-hazards model. A total of 917 patients, 40 to 69 years old, were registered from May 1987 to March 1991. By the end of September 1991, liver cancer had developed in 54. The three-year cumulative risk of liver cancer was 12.5 percent for 240 patients with liver cirrhosis at enrollment and 3.8 percent for 677 patients with chronic hepatitis. Cox regression analysis showed that the risk of liver cancer was increased almost sevenfold in patients with hepatitis B surface antigen (rate ratio, 6.92; 95 percent confidence interval, 2.92 to 16.39) and fourfold in patients with hepatitis C antibody (rate ratio, 4
TY - JOUR. T1 - Complementary and Alternative Medicine Use in Chronic Liver Disease Patients. AU - Ferrucci, Leah M.. AU - Bell, Beth P.. AU - Dhotre, Kathy B.. AU - Manos, M. Michele. AU - Terrault, Norah A.. AU - Zaman, Atif. AU - Murphy, Rosemary C.. AU - VanNess, Grace R.. AU - Thomas, Ann R.. AU - Bialek, Stephanie R.. AU - Desai, Mayur M.. AU - Sofair, Andre N.. PY - 2010/2. Y1 - 2010/2. N2 - To examine a wide range of sociodemographic and clinical characteristics as potential predictors of complementary and alternative medicine (CAM) use among chronic liver disease (CLD) patients, with a focus on CAM therapies with the greatest potential for hepatotoxicity and interactions with conventional treatments. There is some evidence that patients with CLD commonly use CAM to address general and CLD-specific health concerns.. AB - To examine a wide range of sociodemographic and clinical characteristics as potential predictors of complementary and alternative medicine (CAM) use among chronic liver ...
Background and Aims: Advanced glycation end products (AGEs) were found to be involved in the pathogenesis of various disorders. Chronic hepatitis C virus infection is the major cause of liver cirrhosis development and glucose metabolism alteration. We aimed to explore the association of AGEs with the development of diabetes mellitus (DM) in patients with cirrhosis in this study.Methods: Only 144 of the 165 non-diabetic patients with cirrhosis were consecutively included in this prospective cohort pilot study, in addition to 72 healthy control subjects. Clinical data and biochemical parameters including basal insulin secretion and insulin sensitivity indices together with AGEs were evaluated in all participants at baseline and every 1 year thereafter for 2 years. Multivariable Cox regression analysis was used to determine the parameters that could predict the development of DM within this period.Results: DM developed in 14 (10%) patients only. Univariate Cox regression analysis showed that AGEs (P = 0
Cirrhosis of the liver - Exposure to carbon tetrachloride Factor. Last reviewed for CCPS 12 March 2008.. Investigative Documents. Claimant Report - Exposure to Carbon Tetrachloride - Cirrhosis of the Liver [CR9116]. Preliminary questions [20508]. [79]22396. there is some evidence that exposure to carbon tetrachloride may be a factor in the development or worsening of the condition under consideration.. 20585 [80] the veteran has experienced inhalation or cutaneous contact with carbon tetrachloride at some time.. 20586 - the veteran has established the causal connection between exposure to carbon tetrachloride and VEA service for cirrhosis of the liver.. 20587 - the veteran has established the causal connection between exposure to carbon tetrachloride and VEA service for the clinical onset of cirrhosis of the liver.. 20589 - the veteran has established the causal connection between exposure to carbon tetrachloride and operational service for the clinical onset of cirrhosis of the ...
TY - JOUR. T1 - Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population. T2 - a retrospective study of incidental liver biopsies. AU - Zuo, Chunlai. AU - Chumbalkar, Vaibhav. AU - Ells, Peter F.. AU - Bonville, Daniel J.. AU - Lee, Hwajeong. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Background: Idiopathic noncirrhotic portal hypertension (INCPH) is associated with histologic changes secondary to obliterative portal venopathy without cirrhosis. We studied the prevalence of individual histological features of INCPH in liver biopsies obtained incidentally during unrelated elective procedures and in elective liver biopsies with the diagnosis of fatty liver disease. Methods: A total of 53 incidental liver biopsies obtained intraoperatively during unrelated elective procedures and an additional 28 elective biopsies with the diagnosis of fatty liver disease without portal hypertension and cirrhosis were studied. Various histologic features of INCPH were ...
In medicine, specifically gastroenterology, the Child-Pugh score (or the Child-Turcotte-Pugh score or Child Criteria) is used to assess the prognosis of chronic liver disease, mainly cirrhosis. Although it was originally used to predict mortality during surgery, it is now used to determine the prognosis, as well as the required strength of treatment and the necessity of liver transplantation. The score employs five clinical measures of liver disease. Each measure is scored 1-3, with 3 indicating most severe derangement. In primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), some use a modified Child Pugh score where the bilirubin references are changed to reflect the fact that these diseases feature high conjugated bilirubin levels. The upper limit for 1 point is 68 μmol/L (4 mg/dL) and the upper limit for 2 points is 170 μmol/L (10 mg/dL). Chronic liver disease is classified into Child-Pugh class A to C, employing the added score from above. MELD Score MELD-Plus The ...