Bipolar disorder (BD) has been suggested to be associated with accelerated aging and premature cell senescence. While findings on shorter telomeres in BD are controversial, a recent study showed that long-term lithium treatment correlates with longer telomeres in BD. In our study, we sought to investigate the correlation between leukocyte telomere length (LTL) and long-term lithium treatment in a sample of 200 BD patients characterized for lithium response. We also compared data from two different methods commonly used to measure telomere length, quantitative PCR (qPCR) and quantitative fluorescence in situ hybridization (Q-FISH). We also measured, for the first time, the effect of lithium in vitro on the expression of the telomerase gene in human-derived neural progenitor cells (NPCs). Our findings showed that LTL correlated negatively with age (p=0.0002) and was independent of sex, diagnosis, age at onset, suicidal behavior, number of mood episodes, response to lithium and use of other ...
BACKGROUND: The effects of lithium treatment on the thyroid gland have been demonstrated in a number of studies. Most of this research is based on cross-sectional studies and prospective studies are required to confirm these observations. METHOD: During our genetic association studies, we recruited 115 males and 159 females suffering with affective disorders who had received lithium treatment. We observed longitudinally 57 of these patients, who attended our clinic for between 1 and 7 years and had no thyroid abnormalities at baseline. We performed regular checks of thyroid antibodies, thyroid function tests and lithium levels. RESULTS: Hypo- and hyperthyroidism, including cases that developed prior to lithium treatment, were more common in women (25.8%) than in men (8.7%) and increased with age. By the age of 65, the risk in women increased to 50%. Hypothyroidism was induced by lithium in 17% women. In the prospective study, 4 out of 33 women developed hypothyroidism (an incidence of 27.4 cases ...
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BACKGROUND: Mood disorders are common, disabling and tend to be recurrent. They carry a high risk of suicide. Maintenance treatment, aimed at the prevention of relapse, is therefore of vital importance. Lithium has been used for some years as the mainstay of maintenance treatment in bipolar affective disorder, and to a lesser extent in unipolar disorder. However, the efficacy and effectiveness of prophylactic lithium therapy has been disputed. Low suicide rates in lithium-treated patients have led to claims that lithium has a specific anti-suicidal effect. If so, this is of considerable importance as treatments for mental disorders in general have not been shown convincingly to be effective in suicide prevention. OBJECTIVES: 1. To investigate the efficacy of lithium treatment in the prevention of relapse in recurrent mood disorders. 2. To examine the effect of lithium treatment on consumers general health and social functioning, its acceptability to consumers, and the side-effects of treatment. ...
Background Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. Methods Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. Findings A single locus of four linked SNPs on chromosome 21 met genome-wide significance ...
Response to long-term lithium treatment in bipolar disorder appears to be related to the family history of a patient. Conversely, some studies have indicated that treatment response could identify a subtype of bipolar disorder characterized by a stronger role of genetic factors and possibly by major-gene effects. Several groups have now conducted molecular genetic studies in order to identify genes contributing to the etiology of bipolar disorder as well as genes that may influence long-term treatment response. There is limited evidence that the response to mood stabilizers could be individually specific. This chapter focuses on individual treatments, in particular on lithium for which the most data are available. Subsequently, several other studies found an association between prophylactic lithium response and a family history of bipolar disorder. The chapter presents a study of patients with bipolar disorder responsive to lithium in collaboration with the International Group for Study of ...
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OBJECTIVE: Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in nonrandomized studies. The authors conducted a systematic review and meta-analysis of randomized trials to investigate the effect of lithium, compared to placebo and other active treatments, on the risk of suicide, deliberate self-harm, and all-cause mortality in patients with mood disorder. METHOD: The data source was the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register, incorporating results of searches of MEDLINE (1966-June 2002), EMBASE (1980-June 2002), CINAHL (1982-March 2001), PsycLIT (1974-June 2002), PSYNDEX (1977-October 1999), and LILACS (1982-March 2001). The Cochrane Central Register of Controlled Trials (CENTRAL) was searched with the term lithium for new records entered into the database from 1999 to 2003. Studies
In 17 lithium-treated patients with manic-depressive disorders and 11 healthy subjects the concentrations of choline, phosphorylcholine, cytidyldiphosphate choline, lipid bound choline, and...
see article for more examples. Abstract. Unsaturated compounds such as alkenes, alkynes, allenes, and methylenecyclopropanes (MCPs) can be dibrominated within minutes by NBS and lithium bromide in THF at room temperature in good to excellent yields under mild conditions.. ...
BACKGROUND:Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. METHODS:Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. FINDINGS:A single locus of four linked SNPs on chromosome 21 met genome-wide significance ...
BACKGROUND:Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified. METHODS:Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis. FINDINGS:A single locus of four linked SNPs on chromosome 21 met genome-wide significance ...
Im 18 and have been taking lithium ever since I was 14. Does drinking alcohol affect the lithium levels? Im in no means an alcoholic because I have never even tried alcohol but I want to but if it is...
June 30, 2009 Col. Jefferson Rascavage, Commander U. S. Army Corps of Engineers, Wilmington District P. O. Box 1890 Wilmington, NC 29402- 1890 Attn: Scott C. McLendon Re: Memorandum of Agreement ( MOA) Quarterly Report Dear Col. Rascavage: The Ecosystem Enhancement Program ( EEP) is pleased to submit the Fourth Quarterly Report of State Fiscal Year 2008- 2009 to the U. S. Army Corps of Engineers ( USACE), Wilmington District. This Quarterly Report addresses the period beginning April 1, 2009 and ending June 30, 2009. The materials presented within provide information as required under Section VII, Part B of the Memorandum of Agreement among the USACE, the N. C. Department of Transportation ( NCDOT) and the N. C. Department of Environment and Natural Resources ( NCDENR), signed into effect on July 22, 2003. The following actions occurred this quarter: • Throughout this quarter, EEP continued to coordinate matters relative to new federal rule requirements. USACE and EEP have held and continue to ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Objective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods: Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa ($$\kappa$$)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment ...
This study, and several others, have clearly demonstrated that we can use lithium prophylaxis to actually prevent postpartum psychosis and illness.
271, smokeless tobacco, cigars, and pipes. Thompson, Substituent Constants belco Correlation Analysis in Chemistry and Biology, p. Nature 398, 67в69. The authors concluded that long-term lithium therapy is a risk factor for renal impairment.
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Webcat Plus: Statistical methods of econometrics, This now classic volume aims at a systematic presentation of the statistical methods used for the analysis of economic data. The properties of the various procedures are studied within the framework of theoretical stochastic models. Their relevance for inference on the economic phenomena is discussed at length. This third edition has been updated in many respects. Chapter 8 (Regression in Various Contexts) has been rewritten and now provides a full discussion of estimation in the linear models with a partially unknown covariance matrix, which introduces a systematic treatment of heteroscedasticity, random coefficients and composite errors. A new chapter has been added on simultaneous equation models that are non-linear with respect to the endogenous variables. The reader will also find new sections on shrunken estimators, on the choice of a model, on specification and estimation for distributed lag equations.
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The following course material has been developed by the School of Crystallography, Birkbeck College, University of London and has been made available under licence to Professor B T Sewell, for students in the Structural Biology Course.. This module provides a systematic treatment of protein structure and integrates web and computer resources to create a novel teaching environment. Students should work through the material at their own pace and tutorials will be held regularly.. The course is modular and specific outcomes are listed in each section.. ...
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We aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and research uses of the biobank, along with demographics and clinical features of the first participants enrolled. Patients were recruited for the Mayo Clinic Bipolar Biobank beginning in July 2009. The Structured Clinical Interview for DSM-IV was used to confirm bipolar diagnosis. The Bipolar Biobank Clinical Questionnaire and Participant Questionnaire were designed to collect detailed demographic and clinical data, including clinical course of illness measures that would delineate differential phenotypes for subsequent analyses. Blood specimens were obtained from participants, and various aliquots were stored for future research. As of September 2014, 1363 participants have been enrolled in the bipolar biobank. Among these first participants, 69.0 % had a diagnosis of bipolar disorder type I. The group
OBJECTIVE: Depressive episodes are common in bipolar disorder, and the disorder is characterized by high suicide rates. Recent analyses indicate a possible association of antidepressant treatment and suicidality in children and adults with depressive or anxiety disorders. However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder. METHOD: Of the first 2000 participants followed for 18 months in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), 425 experienced a prospectively observed, new-onset major depressive episode without initial suicidal ideation. Standardized ratings of suicidality and antidepressant exposure at index depressive episode and next evaluation were used to investigate the primary hypothesis that new-onset suicidality was associated with increased antidepressant exposure (antidepressant initiation or dose increase). Secondary analysis investigated correlates of new-onset suicidality and
Introduction. Bipolar disorder is a recurrent and chronic disorder with significant morbidity and mortality. It is characterized by a long-term episodic cyclical course of extreme fluctuations in mood that manifest as repeated manic, depressed, or mixed episodes with complete inter-episode recovery but high rates of chronicity that impact social and occupational development (Angst & Sellaro, 2000). According to the Systematic Treatment Enhancement Program for Bipolar Disorder, 5% of patients who fulfill the criteria for recovery suffer relapses each month (Baldassano, 2006). Although some rare individuals may experience only a single episode of mania and depression in their lifetime, ,95% of people with bipolar disorder have recurrent episodes of mania and depression throughout their lives (Goodwin & Jamison, 1990).. Bipolar disorder is a common disorder that affects 1% of the population. This prevalence may increase according to the diagnostic criteria used in each study (Judd & Akiskal, 2003). ...
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Bipolar disorder dates back to the time of Hippocrates (Healy). Hippocrates was the first to put mania and melancholia on our cultural radar (Healy). The symptoms he used to diagnose mania were that of nausea, shivering, insomnia, and lack of thirst (Healy). Until recently, bipolar II disorder has been virtually unknown and highly underdiagnosed. DSM-IV has separated bipolar disorders into two types, bipolar II and I. (Chengappa, Levine, Gershon, Kupfer). These two disorders may have differing genetic, biological, phenomenological attributes and course of illness characteristics (Chengappa, Levine, Gershon, Kupfer). There are many reasons for this. A lack of education regarding the disorder, misdiagnosis, and improper treatments are the number one reason for misdiagnosis. Physicians and mental health clinicians are just now learning the symptoms of bipolar II disorder. During a 2005 chart review, 37% of 90 bipolar II disorder patients were misdiagnosed as having unipolar depression. Bipolar II ...
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Afifi M. Depression in adolescents: gender differences in Oman and Egypt. East Mediterr Health J 2006; 12:61-71.. American Psychiatric Association. Practice Guideline for the Assessment and Treatment of Patients With Suicidal Behaviors. Acessed at http://archive.psych.org/cme/apacme/courses/sections.cfm?apacme=00160008 on 11/1/08.. Angst J, Preisig M. Outcome of a clinical cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985. Schweiz Archiv Neurol Psychiatry 1995; 146: 17-23.. Arato M, Demeter E, Rihmer Z, Somogyi E. Retrospective psychiatric assessment of 200 suicides in Budapest. Acta Psychiatr Scand 1988; 77:454-456.. Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord. 2006; 8:625-39.. Banyard VL, Williams LM, Siegel JA. Re-trumatization among adult women sexually abuse in childhood: exploratory analyses in a ...