The authors evaluated the contributions of nine genetic (G) variants (selected from 275 single nucleotide polymorphisms in 11 reverse cholesterol transport pathway genes), five environmental (E) factors (selected from 10), and G × G, E × E, and G × E interactions in explaining population variance of blood lipid concentrations. Total cholesterol, triglycerides, and high density lipoprotein (HDL) cholesterol were measured, and low density lipoprotein (LDL) cholesterol and HDL cholesterol/LDL cholesterol ratio were calculated in a population-based random sample of 1,543 men and women in Geneva, Switzerland, aged 35-74 years in 1999-2001. Explained variances (R2) for HDL cholesterol/LDL cholesterol ratio, HDL cholesterol, and LDL cholesterol, respectively, were 34%, 33%, and 19%, decomposed into main effects of G (6%, 4%, and 5%) and E (25%, 28%, and 11%), with just 3%, 2%, and 3% due to G × G, E × E, and G × E interactions, respectively. Risk factor clustering was only moderate: 70% of study ...
Dried blood spot (DBS) analysis is a convenient way to collect blood samples with several advantages over conventional blood collection methods. DBS has gained popularity in fields such as newborn screening, preclinical studies, and therapeutic drug monitoring [2, 4, 7, 8]. DBS coupled with LC-MS/MS system provides the capacity to analyze samples in a high throughput manner once coupled to robust analytical methods. Lipidomics analysis of whole blood, which is comprised of thousands of diverse lipid molecular species, is directly linked to an individuals physiological, nutritional and health status [14, 35]. In this study, we combined DBS collection with high-resolution MS/MSALL shotgun lipidomics analysis to analyze the blood lipidome. We demonstrate in one DBS spot, several lipid classes and more than 1,200 lipid species were identified and quantified.. Direct infusion-based MS shotgun lipidomics provides comprehensive profiling and quantitation of lipid species from organic extracts of ...
Lipidomics is the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The huge diversity of native lipids and their modifications make lipidomic analyses challenging. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography. Although shotgun lipidomics allows for high-throughput analysis, low-abundant lipid species are not detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. In this review, we will discuss the potential of lipidomics for cardiovascular research. To date, cardiovascular research predominantly focuses on the role of lipid classes rather than molecular entities. An in-depth knowledge about the molecular lipid species that contribute to the pathophysiology of cardiovascular
Background Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a biomarker. The aim of this study is to identify lipid molecules from hundreds plasma apparent lipid species as biomarkers for diagnosis of prostate cancer. Methodology/Principal Findings Using lipidomics, lipid profiling of 390 individual apparent lipid species was performed on 141 plasma samples from 105 patients with prostate cancer and 36 male controls. High throughput data generated from lipidomics were analyzed using bioinformatic and statistical methods. From 390 apparent lipid species, 35 species were demonstrated to have potential in differentiation of prostate cancer. Within the 35 species, 12 were identified as individual plasma lipid biomarkers for diagnosis of prostate cancer with a sensitivity above 80%, specificity above 50% and accuracy above 80%.
Lipid profile or lipid panel is a panel of blood tests that serves as an initial broad medical screening tool for abnormalities in lipids, such as cholesterol and triglycerides. The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases. Lipid panels are commonly ordered as part of a physical exam, along with other panels such as the complete blood count (CBC) and basic metabolic panel (BMP). The lipid profile typically includes: Low-density lipoprotein (LDL) High-density lipoprotein (HDL) Triglycerides Total cholesterol Using these values, a laboratory may also calculate: Very low-density lipoprotein (VLDL) Cholesterol:HDL ratio The lipid profile tests are of 7 types: Total lipids Serum total cholesterol serum HDL cholesterol Total cholesterol/HDL cholesterol ratio Serum triglycerides serum Phospholipids Electrophoretic fractionation to determination percentage of (a) ...
Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids.. Methods: Participants from the GLACIER Study (N-max = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms;replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (Delta TC) and triglycerides (Delta TG). Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; N-max = 8263 participants) were used for replication. We conducted an in silico look-up for association with coronary artery disease (CAD) in the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAMplusC4D) Consortium (N similar to 190 000) and functional annotation for the top ranking variants.. Results: In total, 956 ...
This report presents an analysis of data resulting from a lipidomics experiment. The experiment sought to determine the changes in the lipidome of big bluestem prairie grass when exposed to stressors. The two stressors were drought (versus a watered condition) and a rust infection (versus no infection), and were whole plot treatments arranged in a 2 by 2 factorial. A split plot treatment factor was the position on a sampled leaf (top half versus bottom half). In addition, samples were analyzed at different times, representing a blocking factor. A total of 110 samples were used and, for each sample, concentrations of 137 lipids were obtained. Many lipids were not detected for certain samples and, in some cases, a lipid was not detected in most samples. Thus, each lipid was analyzed separately using a modeling strategy that involved a combination of mixed effects linear models and a categorical analysis technique, with the latter used for certain lipids to determine if a pattern of observed zeros ...
Background: Inactivity is a leading contributor to chronic health problems. Physical activity (PA) is an important element in maintaining the health and functional ability in the population and has favorable effects on lipid profile in adults. Here, we examined the effects of pedometer-based PA (step/day ) in healthy middle age men. Methods: ...
Previous studies have suggested that whey supplementation may have beneficial effects on lipid profiles, although results were inconsistent. A literature search was performed in March 2015 for randomized controlled trials observing the effects of whey protein and its derivatives on circulating levels of triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). A meta-analysis was subsequently conducted. The meta-analysis results of 13 trials showed that whey supplementation significantly reduced the circulating TG level by 0.11 mmol/l (95% CI: -0.21, 0 mmol/l), whereas the whey protein had no effects on circulating TC (-0.11 mmol/l, 95% CI: -0.27, 0.05 mmol/l), LDL-C (-0.08 mmol/l, 95% CI: -0.23, 0.07 mmol/l) and HDL-C (0.01 mmol/l, 95% CI: -0.04, 0.05 mmol/l). Subgroup analysis showed that significant TG reduction disappeared in participants with low body mass index, low supplemental whey dose or under exercise ...
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimers disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (C) ...
Background: Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, but the mechanism for this risk remains unclear. Complicating this association, reducing serum homocysteine (Hcy) has not been shown to decrease cardiovascular disease events in randomized controlled trials. This study aims to examine the relationship between Hcy and several lipid measures.. Methods: Our analyses included a subset of 18,297 U.S. adults from the Very Large Database of Lipids, who had an extended lipid panel by density gradient ultracentrifugation, which included direct measurement of triglycerides (TG), and the cholesterol concentration of low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, very low-density lipoprotein (VLDL-C), and remnant-lipoprotein cholesterol (RLP-C: IDL-C + VLDL3-C). Additional measurements were levels of Hcy, hemoglobin A1c (HbA1c), insulin, creatinine, and blood urea nitrogen (BUN). Subjects were categorized into Hcy quartiles. Linear ...
This is calculation with bound lipids. Acyl chains of two lipids were modelled. Calculated hydrocarbon boundary of the lipid bilayer corresponds to the carbonyl groups of the bound lipid. Depending on conformations of bound lipids, the protein can penetrate deeper by ~2 A. Results for the dimer without bound lipids are exactly the same as for lipid-free EEA1 monomer (1hyi). Transfer energy was calculated without contribution from the bound lipid ...
The presentations reflected the early development of LipidomicNet, the European Union Framework VII project focused on the structure of lipid droplets and their function in human health and disease that kicked off just last year. Lipid droplet formation is a hallmark of "energy-overload" metabolic diseases that are a major heath concern. One goal of LipidomicNet is to integrate lipid structure profiles with proteome and transcriptome analysis to reveal the interrelationship between gene expression and lipid droplet formation.. The project also manages the LipidomicNetWiki (www.lipidomicnet.org), in close collaboration with LIPID Metabolites and Pathways Strategy (LIPID MAPS) and Lipid Bank-Japan. One hope is that those investigators who "bump" into lipid metabolism in their work will take advantage of the LipidomicsWiki to help sort out the cellular responses to metabolic stress.. All members of the Lipidomics Expertise Platform are allowed to edit and add content to LipidomicNet-Wiki, so I ...
Effect of Ledebouriella seseloides Extracts on Lipid Parameters in Ovariectomized Rats - ALP;collagen;Ledebouriella seseloides;lipid parameters;ovariectomized rats;
Highlights: • Lipid in municipal biomass would not inhibited the anaerobic digestion process. • A lipid concentration of 65% of total VS was the inhibition concentration. • The amount of Brevibacterium decreased with the increasing of the lipid contents. • Long chain fatty acids stacked on the methanogenic bacteria and blocked the mass transfer process. - Abstract: The influence of the lipid concentration on the anaerobic co-digestion of municipal biomass waste and waste-activated sludge was assessed by biochemical methane potential (BMP) tests and by bench-scale tests in a mesophilic semi-continuous stirred tank reactor. The effect of increasing the volatile solid (VS) concentration of lipid from 0% to 75% was investigated. BMP tests showed that lipids in municipal biomass waste could enhance the methane production. The results of bench-scale tests showed that a lipids concentration of 65% of total VS was the inhibition concentration. Methane yields increased with increasing lipid ...
article{bcb56acf-af8b-4795-9113-593c8f47c227, abstract = {Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East ...
The study of lipid transfer between lipid membranes is of great interest for the fundamental understanding of this complex and important process and, furthermore, for providing a new avenue for the in situ modification of supported lipid bilayers (SLBs). SLBs are conveniently formed by vesicle spreading onto a solid support, but this method is limited to conditions (i.e., combination of vesicle lipid composition, surface chemical properties, and buffer) such that the vesicles break spontaneously upon adsorption to the surface. Many SLB compositions are not accessible by this approach. In the present study, we give an example of how lipid transfer can be made use of to form lipid layers with striking new features, notably with respect to stability. After lipid transfer between negatively charged POPS small unilamellar vesicles and a positively charged POEPC SLB on TiO2, an SLB is obtained, which, upon exposure to SDS, leaves behind a lipid monolayer. It is shown how this monolayer can be used for
The effects of elevated blood lipid concentrations on cardiovascular mortality and morbidity are reviewed, with particular emphasis on how high fat diets and antihypertensive drugs can influence the...
Lipid-based diseases are a growing and expensive challenge to health care systems. As a population ages, chronic conditions associated with aging such as cardiovascular disease, neurodegenerative disorders, and metabolic disorders take increasing tolls in terms of morbidity and mortality. Oxidation of lipids and lipid metabolites has been linked to disorders of aging like osteoporosis and vascular calcification. Additionally, research is now trying to explain how dysregulations in lipid metabolism may underlie diseases such as Alzheimers, cancer, and asthma. Lipid synthesis pathways, such as the methyl-Derythritol 4-phosphate (MEP) pathway of isoprenoid synthesis, are being investigated as potential targets for antibacterial therapies and drug targets. As changes in lipid profiles can mark developmental stages or more ominously, pathological states, there is great potential for the use of lipids as biomarkers. Experimental quantification of the levels of lipids and lipid metabolites is ...
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research - have not changed since previous editions.. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry.. An introductory chapter summarizes the types of lipids covered and their identification and provides ...
Aim: To investigate relationship between serum TSH and lipid parameters in subjects with different levels of TSH. Study Design: Cross-sectional study. Place and Duration of Study: Clinical Biochemistry Department of Kasturba Medical College, Hospital Mangalore, between January 2014 to June 2014. Methodology: 348 subjects were screened of which 194 were selected. Lipid parameters, TSH, T3, T4 and glycemic status were determined. Association between TSH and serum lipids were studied by categorizing subjects into three groups based on their thyroid status. Group 1 [TSH= 0.27-2.5 mIU/L], Group 2 [TSH= 2.6-4.12 mIU/L] and Group 3 [TSH= 4.13-9.9mIU/L].Statistical analysis was performed by ANOVA followed by Tukeys multiple comparison test. The relationships between TSH and different parameters were evaluated by Pearsons correlation analysis. Results: TSH showed a significant positive linear correlation with total cholesterol (r=0.288; P = 0.001), Triglycerides (r=0.129; P=0.016), LDL cholesterol ...
A lipid panel is a safe procedure with minimal risks. Some kids might feel faint or lightheaded from the test. A few kids and teens have a strong fear of needles. If your child is anxious, talk with the doctor before the test about ways to make the procedure easier.. A small bruise or mild soreness around the blood test site is common and can last for a few days. Get medical care for your child if the discomfort gets worse or lasts longer. If you have questions about the lipid panel, speak with your doctor or the health professional doing the blood draw.. Back To Top. ...
Awhile ago, TheFatNurse noticed something strange while reviewing some Lipid panels. Normally, when you receive a lab result, a reference range is given and any numbers above or below the reference range is flagged. What was strange about some of these lipid panels was the lack of flags for patient numbers that were clearly in…
Am J Clin Nutr. 1998 Dec;68(6 Suppl):1375S-1379S. Clinical Trial; Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Govt
The role of lipid biomarkers in assessing the risk of cancer has not been studied in detail. However, lipid metabolism has now been accepted as a major metabolic pathway involved in many aspects of cancer cell biology (9). In this context, the contribution of dietary factors, such as different types of fatty acids, carbohydrates, and added sugars may be of importance. Hence, it is likely that future therapeutic strategies for cancer will include dietary regimes. Blood lipids and lipoproteins may influence the risk of cancer through insulin resistance, inflammation, and oxidative stress (10 ...
Study aim: To determine the effects of indoor cycling training combined with restricted diet, lasting 12 weeks, on serum lipid concentrations in obese women.Material and methods: Twenty women aged 23.8 ± 3.6 years were randomly assigned into two groups: control (C) and experimental (E), the latter subjected to indoor cycling at various loads, 3 sessions weekly, every session lasting 45 min, combined with restricted diet (about 1200 kcal daily) for 12 weeks. The following variables were recorded: body height and mass, BMI, relative body fat content (from 7 skinfolds), fat-free mass, triglycerides, cholesterol and lipoproteins (HDL, LDL, VLDL).Results: Significant increase in HDL and significant decreases in all other variables (except body height) were noted only in the experimental group.Conclusions: Indoor cycling associated with restricted diet is an excellent option in controlling obesity and serum lipids ...
Colleagues, We are delighted to launch the new LIPID MAPS Lipidomics Gateway, funded by the Wellcome Trust and jointly hosted by Cardiff University, Babraham Institute and University of California San Diego (UCSD). These are exciting times as we move forward with Phase II of this global project. Our new site provides easier access to the most utilized areas: Lipid Classification System; Structure Database; and Tools. Curation has restarted, with over 500+ new lipid molecules added in the last few months with many now featured in our structure drawing tools. Back in 2016, we asked you what you would like to see on LIPID MAPS, and in response we provide new features including raw MS data deposition in collaboration with Metabolomics Workbench (which already hosts over 500 lipidomics studies), and statistical analysis tools. We include a contact form for you to get in touch with us and provide feedback. We also have a registration facility, and will be using this as a mailing list in the coming ...
These experiments were designed to study the topography of lipid deposition in the stenotic aorta of hypercholesterolemic rats, and to correlate it with flow conditions and intimal stresses and strains studied in a scale biophysical model and in a computer model. A 69% +/- 5% stenosis was produced with a U-shaped metal clip. One month to 8 months later, the aorta was studied en face by light microscopy after fixation and lipid staining. The intima in the throat of the stenosis was almost completely free of lipid, whereas symmetric lipid deposits occurred as bands just above and especially just below the stenosis; elsewhere lipid deposits appeared to be random. The flow data obtained from the scale model showed that the intima in the throat of the stenosis was subjected to an increase of as much as 20 times in shear stress, whereas the lipid deposits just above and just below the stenosis were associated with asymmetric flow conditions: the proximal area corresponded to a region of rapidly increasing
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Use the Lipid Panel with Total Cholesterol:HDL Ration to monitor your cholesterol. With Request A Test, ordering your own lab testing couldnt be easier or more convenient. Order your lab tests, give your sample, get results. Call or go online to order today.
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL)
Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individuals were performed to identify genetic variants that modify the effect of loop or thiazide diuretic use on blood lipid concentrations. Both longitudinal and cross sectional data were used to compute cohort-specific interaction results, which were then combined through meta-analysis in each ancestry. These ancestry-specific results were further combined through trans-ancestry meta-analysis. Analysis of EA data identified two genome-wide significant (p , 5 × 10−8) loci with single nucleotide variant ...
Buy, download and read Plasma Lipids and Their Role in Disease ebook online in PDF format for iPhone, iPad, Android, Computer and Mobile readers. Author: Philip Barter; Kerry-Anne Rye. ISBN: 9781482298253. Publisher: CRC Press. This volume gives up-to-date information on plasma lipid transport, the various categories of plasma lipid disorders and the relationship between plasma lipids, lipoproteins, and atherosclerotic disea
WebMD explains the tests used to diagnose high cholesterol, including a total cholesterol test, lipoprotein analysis, lipid panel, and LDL test.
National levels of triglycerides and low-density lipoprotein (LDL) cholesterol in adults have fallen even more drastically since 2011 than what had been previously observed since the turn of the century, according cross-sectional survey data. Additionally, these trends were maintained regardless of the use of lipid-lowering medications.. Given that lipid levels are strong predictors of cardiovascular health, this information is "a good indicator that the US populations lipid profile is improving at a population level," study author Asher Rosinger, PhD, MPH (Centers for Disease Control and Prevention, Hyattsville, MD), told TCTMD. "If these predictors of cardiovascular events continue to move in this favorable direction, its likely that mortality trends will also continue in a favorable direction.". For the study, Rosinger and colleagues culled lipid data on almost 40,000 adults from the National Health and Nutrition Examination Survey between 1999/2000 and 2013/2014. The results-published ...
Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their Possible Biosynthetic Pathways as Deduced from the Genome Sequence.Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their Possible Biosynthetic Pathways as Deduced from the Genome Sequence. ...
|p|Lipids in Health and Disease publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.|/p|
Back in May, 2006, I last had some blood work done, for an insurance exam, that included a lipid panel. I, of course, held onto those results, because I obsess over my risk factors for heart disease. Here they are, in their unimpressive glory. Total Cholesterol - - - 197 [|200] HDL-C - - -…
1) Lipid is a fatty substance found in the blood. Lipid metabolism is the conversion of the fat molecule from fat to energy (and other by-products). (2) lipid /lip·id/ (lip´id) any of a heterogeneous group of fats and fatlike substances, including fatty acids, neutral fats, waxes, and steroids, which are water-insoluble and soluble in nonpolar solvents. Lipids, which are easily stored in the body, serve as a source of fuel, are an important constituent of cell structure, and serve other biological functions. Compound lipids comprise the glycolipids, lipoproteins, and phospholipids. See also: Lipid ...
Got a lipid panel done the other day and it seems some of my numbers are off. Specifically My HDL or good cholesterol. I dont know a lot about this stuff since my results are always fine, but this is the first time i Have had one done on cycle. I am on test 500mg a week dbol 30mg ed Just stopped 4 days before the test adex .5 eod Here is my panel from the other day Cholesterol Total 139 HDL 25 LDL 104 Non HDL 114 Triglyceride 52 Chol risk ratio 5.6 Here is my panel from last year not juici...
Diagnosis. Patients with diabetes may have atypical presentations for CVD. Screening with electrocardiogram or cardiac stress tests may be appropriate in some patients. Hypertension. Blood pressure control is particularly important for individuals with diabetes. The goal blood pressure should be less than 130/80 mmHg, and further lowering may be beneficial (see Hypertension ).. Hyperlipidemia. The goals for blood lipid concentrations are also somewhat different for patients with diabetes. LDL should be less than 100 mg/dl, and in certain patients (especially those with known CVD), the goal may be less than 70 mg/dl. In known cases of CVD, triglycerides should be less than 150, and HDL greater than 40 mg/dl. HDL greater than 50 mg/dl may be an appropriate goal for women (see Hyperlipidemia ).. Treatment. Dietary and behavioral modifications, including smoking cessation, regular exercise, and loss of excess weight, are critical for the prevention and management of cardiac complications in diabetes ...
The Lipidizer™ Platform offers a complete lipid analysis solution that can differentiate and quantify over a thousand lipid molecular species across 13 lipid classes
Lipid A is a major constituent of the lipopolysaccharides (or endotoxins), which are complex amphiphilic macromolecules anchored in the outer membrane of Gram-negative bacteria. The glycolipid lipid A is known to possess the minimal chemical structure for LPSs endotoxic activity, able to cause septic shock. Lipid A isolated from extremophiles is interesting, since very few cases of pathogenic bacteria have been found among these microorganisms. In some cases their lipid A has shown to have an antagonist activity, i.e., it is able to interact with the immune system of the host without triggering a proinflammatory response by blocking binding of substances that could elicit such a response. However, the relationship between the structure and the activity of these molecules is far from being completely clear. A deeper knowledge of the lipid A chemical structure can help the understanding of these mechanisms. In this manuscript, we present our work on the complete structural characterization of the lipid A
The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-recognition of a major histocompatibility complex molecule and its carried peptide. However, the molecular basis of the interactions of TCRs with the lipid antigen-presenting molecule CD1c is unknown. We identified frequent staining of human T cells with CD1c tetramers across numerous subjects. Whereas TCRs typically show high specificity for antigen, both tetramer binding and autoreactivity occurred with CD1c in complex with numerous, chemically diverse self lipids. Such extreme polyspecificity was attributable to binding of the TCR over the closed surface of CD1c, with the TCR covering the portal where lipids normally protrude. The TCR essentially failed to contact lipids because they were fully seated within CD1c. These data demonstrate the sequestration of lipids within CD1c as a mechanism of autoreactivity and point to small lipid size as a determinant of autoreactive T cell responses.. ...
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced gly
This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.
In a large and growing body of scientific evidence nutritional lipids have shown significant health benefits and support brain, eye and cardiovascular health throughout life. Leading experts around the world have noted that healthy lipids such as DHA, EPA and ARA are important nutrients for health throughout the life cycle, yet many consumers do not include enough in their daily diets. The nutritional lipids category of health and nutrition ingredients is science-based, fast growing and in an early stage of development, with significant growth opportunities. Products from DSMs Nutritional Lipids portfolio can already be found in more than 400 brands of infant formula, nutritional supplements, functional foods and animal feeds sold worldwide.. Peter A. Nitze, who joined Martek in 2005 and held the position of COO at the time of the acquisition, will lead Nutritional Lipids as President and will be based in Columbia, Md. (United States). Steve Dubin, Marteks CEO at the time of acquisition, will ...
[ Trends In Serum Lipids Among ] - Trends In The Prevalence Of Chronic Medication Use In Children,Rationale For Aggressive Lipid Lowering In High Risk Patients,A Lipidomics Analysis Of The Relationship Between Dietary Fatty
Biosystems Control Serum Lipids Level 2 Yüksek Kaliteli Biosystems test kitleri ve Cihazlarımızla kolaylıkla ve dakikalar içerisinde analiz sonuçlarına ul | Biyokimya Kitleri
Th ADMEPGx (n 74 genes) and. Before we get into the big job of interpreting cholesterol numbers, lets review what cholesterol actually is. Target genes of the absorption, distribution, metabolism, and excretion (ADME)pharmacogenetic (PGx) capture panels. Olesterol is cholesterol: a waxy steroid oEfficient protein delivery using cationic lipid transfection reagents enables high efficiency protein based genome editing in vivo and in vitro. Diabetes mellitus is a complex, chronic illness requiring continuous medical care with multifactorial risk reduction strategies beyond glycemic control? Th ADMEPGx (n 74 genes) and. a, b, S. At can we help you find. Obesity Online Medical Reference discusses obesity and strategies for weight management. Cholesterol comes from two sources the body and food and either one can contribute to high cholesterol. Reus were grown to early (a), and late (b) exponential phase and challenged with antibiotics. Ta are representative of 3 independent experiments s. ...
Lipid Soluble, Wholesale Various High Quality Lipid Soluble Products from Global Lipid Soluble Suppliers and Lipid Soluble Factory,Importer,Exporter at Alibaba.com.
The lipid fraction of latent fingermark residue encompasses a number of compounds crucial to fingermark detection on wetted porous substrates. This thesis describes investigations into the detection and chemical analysis of the lipid fraction of latent fingermarks. Two novel reagents for fingermark detection were developed from lipophilic histological stains. Chemical analysis of fingermark lipids found insufficient variation to discriminate between individuals or donor traits, however significant differences were observed as a function of sample age.. ...
LIPIDS NEUTRAL LIPIDS (Triglyceride) PHOSPHOLIPIDS GLYCOLIPIDS STEROIDS The structural units of lipids are glycerol and fatty acids. The type and function of the lipid molecule differs due to the type of fatty acid.
KD of TIP47 results in defects in the cellular response to feeding with oleic acid. Although the uptake of fatty acids, the breakdown of TAG, and the export of fatty acids from the cells remain normal, the growth and maturation of LDs are inhibited. In immunofluorescence, the droplets appeared heterogeneous with respect to size, and the amount of LD-stored TAG was reduced even though we were unable to suppress TIP47 completely. The reduction in LD-stored TAG was confirmed by lipid analysis of isolated LDs. We consider it unlikely that TIP47 has a direct function in neutral lipid synthesis. Instead, KD of TIP47 probably affects the cellular capacity to store neutral lipids in LDs. If so, TAG or precursors such as diacylglycerol should accumulate elsewhere in the cell, for example, at or between dilated ER leaflets. Unfortunately, it is very difficult to validate this hypothesis because such structures are probably smaller than the spatial resolution of light microscopy and very fragile, thus ...
Nearly 10 million Americans have stable ischemic heart disease (SIHD), which ranks among the leading causes of death among adults in the United States. According to study data, SIHD was the cause of nearly 380,000 deaths in the.... Read More ...
In this video, Dean Karalis, MD, delves into a chief concern for preventive cardiologists-the effort to lower lipid levels and thereby reduce the risk of cardiovascular disease. A preventive cardiologist, Dr. Karalis describes the pathogenesis of atherosclerosis, and the present and future agents in place to lower lipid levels, describing first the mechanisms, concerns and issues identified with the statins, and the approach of the recently approved PCSK9 inhibitor alirocumab. A natural occurring protein, PCSK9 binds to the low-density lipoprotein receptor to promote its degradation in the liver. Dr. Karalis discusses this mechanism, findings from the pre-approval studies for alirocumab and the indications for the drug.. ...
Lipid Panel Control was defined as achieving target for one or more of the following parameters: low-density lipoprotein cholesterol (LDL-C) at goal (,100mg/dL), high-density lipoprotein cholesterol (HDL-C) within normal range (40mg/dL for males and 50mg/dL for females), and/or triglycerides within normal range (≤ 150mg/dL ...
List of 16 disease causes of Lipid abnormality, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Lipid abnormality.
Most adults who are getting regular preventive healthcare are familiar with the lipid panel performed as a routine check for cholesterol levels. What they may not know is that the standard lipid panel can only identify about 40% of the people who are at high risk for heart disease. The result of this is that many adults mistakenly believe they have reduced their heart attack risk when they are actually carrying around ticking time bombs that could be defused with improved treatment. While the exact treatment for blood lipid problems varies, doctors seldom consider any such treatments without the test data to justify them. You could argue that the conventional cholesterol test actually increases the risk for heart attacks by leaving people unwisely complacent because of incomplete and inaccurate information about the nature of the fats in their blood. For instance, the LDL cholesterol number for "bad" cholesterol in the conventional tests is just a calculated estimate, not a direct measurement. ...
A lipid is a fatty substance that cant dissolve in blood. Cholesterol, cholesterol compounds and triglycerides are all lipids. They are transported in the blood as part of large molecules called lipoproteins. Abnormalities in lipids can contribute to heart disease.. ...
Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It...
Istilah lipid ngawengku rupa-rupa molekul, malah kaasup sanyawaan nu rélatif teu leyur na cai atawa nonpolar nu asalna tina mahluk hirup, kayaning malam, asam lemak, fosfolipid, sfingolipid, jeung glikolipid turunan asam lemak sarta terpenoid kayaning rétinoid jeung stéroid. Sababaraha lipid mangrupa molekul liniér alifatik, sedengkeun nu séjénna mibanda struktur cingcin. Sababaraha di antarana aromatik, sedengkeun nu séjénna henteu. Sababaraha di antarana fléksibel, sedengkeun nu séjénna kaku.. Lipid loba mibanda ciri polar ti antara lolobana ciri nonpolarna. Umumna, guruntulan strukturna mah nonpolar atawa hidrofobik ("sieun cai"), nu hartina teu ngahiji jeung pangleyur polar kawas cai. Bagian séjén tina strukturna mibanda ciri polar atawa hidrofilik ("resep cai") sarta condong ngahiji jeung pangleyur polar kawas cai. Sipat ieu ngajadikeun lipid kaasup molekul amfifilik (mibanda boh bagian hidrofilik jeung hidrofobik). Dina kasus koléstérol, gugus polarna mangrupa -OH (hidroxil ...
The Mission of the National Lipid Association (NLA) is to . . . Enhance the practice of lipid management in clinical medicine. Consistent with the mission statement, the National Lipid Associations goals are:
Lipids are a large and diverse group of biological molecules with roles in membrane formation, energy storage and signaling. Cellular lipidomes may contain tens of thousands of structures, a staggering degree of complexity whose significance is not yet fully understood. High-throughput mass spectrometry-based platforms provide a means to study this complexity, but the interpretation of lipidomic data and its integration with prior knowledge of lipid biology suffers from a lack of appropriate tools to manage the data and extract knowledge from it. Aimo, Lucila; Liechti, Robin; Hyka-Nouspikel, Nevila; Niknejad, Anne; Gleizes, Anne; Götz, Lou; Kuznetsov, Dmitry; David, Fabrice P A; van der Goot, F Gisou; Riezman, Howard; Bougueleret, Lydie; Xenarios, Ioannis; Bridge, Alan
A lipid profile is a blood test used to measure a persons cholesterol and triglyceride levels. Having a lipid profile test can...
Summary of Meeting. The identification of many receptors and targets of bioactive lipid mediators has led to research uncovering their roles in regulating many important normal and pathophysiological processes. It has become evident that the biological activities and functions of lipid signaling molecules are dependent on both their molecular structures and complex cell-specific interactions among the different pathways involved in their biosynthesis and metabolism. The growing complexity of these interactions and the thousands of cellular lipids, together with genomics and proteomics technology already in place, has emphasized the need for development of complementary lipidomics technology. The goal of this meeting is to bring investigators studying signaling and metabolism of bioactive lipids together with researchers who are now developing lipidomics methods for exhaustive characterization and systematic measurement by mass spectrometry of the lipidome, ie cellular lipids, their precursors ...
My doctor said that my lipid levels are cause for concern. Any dos and donts you can share? asks Brandon, a person living with HIV in Canada. Several ...
Lipids are a different and ubiquitous cluster of compounds having key biological functions like structural constituents of cell membranes, aiding as energy storage bases and play a part in cell signaling pathways. Compound research in structural diversity of lipids benefits developments in the field of membrane lipids which in turn explains biological phenomena at the nanoscale sphere. Multiple roles can be performed by Phospholipids in cells by creating the permeability blockade for cells and cell organelles and by providing the matrix for the association and utility of a wide diversity of catalytic developments, also by substitute as donors in the production of macromolecules, and by keenly inducing the functional properties of membrane-associated developments.. ...
Although protein-based drugs have shown success, they have been limited mostly to cytokines, growth factors, enzymes and monoclonal antibodies, all of which function primarily extracellularly.
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Lipid profiles in the rosettes of WT, ACBP3-OEs and ACBP3-KOs after LS treatment.(a) Content of lipid species of 4-week-old WT, ACBP3-OEs (OE-1 and OE-4) and AC
All types of dietary fats contain lipids. Fat-soluble vitamins that are present in foods also contain lipids. Lipids are greasy, water-insoluble organic compounds that are primary building blocks of...
Story ideas from the May 2007 issue of the Journal of Lipid Research include why fish and seafood are better than olive oil and nuts against heart disease; too much cholesterol in a cell organelle can cause heart disease; why Down Syndrome individuals develop Alzheimers disease earlier than the general population; and how lipids anchor proteins on cell membranes.
In a meal-eating omnivore such as the human, excess calories are ingested in the anabolic phase of the feeding cycle, followed by a period of negative caloric balance when the organism draws upon its carbohydrate and fat stores. Lipoproteins mediate this cycle by transporting lipids from the intestines as chylomicrons-and from the liver as very low density lipoproteins (VLDL)-to most tissues for oxidation and to adipose tissue for storage. Lipid is mobilized from adipose tissue as free fatty acids (FFA) bound to serum ...
Assessment of the abilities of 12 current lipid force fields (*) to correctly sample the lipid headgroup and glycerol conformations, that is, to reproduce accurate NMR order parameter data. (*) Berger, CHARMM36, GAFFLipid, Lipid14, Slipid, Poger, Kukol, Chiu, Hogberg, OPLS-AA, Ulmschneider, Maciejewski-Rog.
HDL. This is a faction that is produced by the liver and intestine. It fulfills two main tasks. First, is the main transport of cholesterol from peripheral tissues and other plasma lipid fractions
View Lipids from BIOLOGY MCB2010 at Broward College. Lipids have 3 major roles in cells. They provide an important form of energy storage. They are the major components of cell membranes. They play
View Notes - Chapter 7 from HUEC 2010 at LSU. Chapter 7: Lipids o Lipids o Organic substances that are relatively insoluble in water and soluble in organic solvents Fats • Solid at room temperature
The Mission of the National Lipid Association (NLA) is to enhance the practice of lipid management in clinical medicine. Consistent with the mission statement, the National Lipid Associations goals are:
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Lipid Profile GLU-kassetten til bruk med LDX systemet måler totalt kolesterol (TC), et mål for total mengde av kolesterol i blodet, HDL-kolesterol (lipoprotein med høy tetthet) («god kolesterol») og triglycerider eller TRG (fettsyrer og glyserol som sirkulerer i blodet og lagres som kroppsfett), samt glukose (GLU), et mål for blodsukker. Lipid Profile•GLU beregner også TC/HDL-forholdet, ikke-HDL kolesterol og estimerer nivået av LDL-kolesterol («dårlig kolesterol ...
I started Paleo January 2011. This is a comparison of my lipids panel from Sep 2010 (pre-paleo) and Sep 2011 (9 months paleo). I told my doctor that I
Avanti Polar Lipids is a specialist manufacturer of phospholipids, sphingolipids, sterols, detergents, antibodies, acyl coenzyme A, fluorescent & bioactive
Lipid levels among adults in the United States appear to have improved between 1988 and 2010, according to a cross-sectional data analysis. Average total cholesterol decreased from 206 mg/dL to 196 mg/dL. Average LDL-cholesterol dropped by 13 mg/dL, while average HDL-cholesterol increased.. Abstract: JAMA, October 17, 2012.. ...
Lipid Technologies, LLC is an analytical services and biotechnology consulting company that specializes in the areas of fatty acid and lipid analysis, nutrition and biochemistry consulting.. ...
Lipids are fats and oils, they are important in Biology because they make membranes. An example of a lipid is triglyceride, made of glycerol and fatty acids. Phospholipids have a phosphate group.
Fats, or lipids, are the third main class of the macronutrients needed in human nutrition. The lipids are found primarily in meats and dairy foods, at least, these are the most visible sources, but most foods contain some fat.
Get an answer for Consider the three major classes of biologically important molecules: proteins, lipids, and nucleic acids. Which steps of the miniprep procedure act on proteins? On lipids? On nucleic acids? and find homework help for other Science questions at eNotes
Study Flashcards On BioChem: Lipid Biosynthesis at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
definition of JLMCS, what does JLMCS mean?, meaning of JLMCS, Journal of Lipid Mediators and Cell Signalling, JLMCS stands for Journal of Lipid Mediators and Cell Signalling
Story ideas from the October 2007 issue of the Journal of Lipid Research include the study of the health effects of a relatively recent diet called alternate-day fasting; how atorvastatin reduces cholesterol and fat in blood vessels; how nutrition affects the breakdown of fats; and a review of intriguing structures on the surface of fat cells called caveolae.
SimLipid® is a high throughput lipid identification tool. It accepts experimental MS and MS/MS data, enables lipids profiling by searching precursors against the known lipid structures and elucidates an unknown structure by matching experimental product ions against theoretical fragments of lipids from the database. It also supports LC-MS and LC-MS/ MS high throughput data processing methods providing a platform for further qualitative and quantitative data analysis. ...
Reducing lipid levels in high-risk patients can significantly reduce disease burden and, depending on final negotiated prices, PCSK9 inhibitors can make an economic contribution to this goal.
Testing for cholesterol levels and more with lipid profiles in Hartsdale, NY. You can protect your health and your heart schedule your test today.
The lipid group, as defined nowadays, is a more heterogeneous group than that of carbohydrates and the proteins. It may be subdivided into: (1) Lipids proper (esters or amides of a fatty acid -...
0174] In one aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is a compound of the general structure (I). In another aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is a compound of the general structure (II). In still another aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is a compound of the general structure (III). In yet another aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is a compound of the general structure (IV). In a further aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is a compound of the general structure (V). In one aspect of the foregoing embodiments, the at least one synthetic disaccharide lipid compound of the present disclosure is ...
Background: Chromium is a micronutrient, considered to be essential for birnak carbohydrate and lipid metabolism. Several studies have demonstrated the beneficial effect if chromium on the glycemic status and lipid profile of type 2 diabetes mellitus. Objective: To study the effect of chromium supplementation on glycemic status and serum lipid concentrations in type 2 diabetes mellitus. Method: Sixty type 2 diabetic patients were randomly assigned to two groups. A double blind technique was used and the patients received either 250æg of chromium picolinate or placebo for 12 weeks. The fasting blood glucose, glycated haemoglobin, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triacylglycerol concentrations were measured at baseline and 2,4,6,8,10 and 12 weeks after initiation of treatment. Serum insulin concentration was also measured at baseline and 12 weeks after initiation of treatment. Results: The fasting blood glucose, glycated ...
TY - JOUR. T1 - Disruption of Synechocystis PCC 6803 for lipid extraction. AU - Sheng, J.. AU - Vannela, R.. AU - Rittmann, Bruce. PY - 2012. Y1 - 2012. N2 - In order to extract intracellular lipids from cyanobacterial Synechocystis PCC 6803 for biofuel production, seven cell-disruption methods - autoclaving, bead beating, freeze drying, French press, microwave, pulsed electric fields (PEF), and ultrasound - were tested prior to lipid extraction to make intracellular lipids more accessible by organic solvents. The different methods brought about distinct disruption effects to the cell envelope, plasma membrane, and thylakoid membranes that were related to extraction efficiency. Microwave, PEF, and ultrasound with temperature control had significant enhancement of lipid extraction (9-13% increases). Bead beating, freeze drying, and French press did not provide significant enhancement of lipid extraction. Furthermore, autoclaving, French press, and ultrasound treatments caused significant release ...
In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray ...
TY - JOUR. T1 - High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease. AU - Baragetti, A.. AU - Norata, G. D.. AU - Sarcina, C.. AU - Rastelli, F.. AU - Grigore, L.. AU - Garlaschelli, K.. AU - Uboldi, P.. AU - Baragetti, I.. AU - Pozzi, C.. AU - Catapano, A. L.. PY - 2013/9. Y1 - 2013/9. N2 - Objectives: Patients with chronic kidney disease (CKD) often present with reduced plasma HDL cholesterol (HDL-C) levels. Whether this reduction in an epiphenomenon or is involved in disease progression is unclear. The aim of this study was to investigate the relation between HDL-C levels/function and CKD progression in patients with different degrees of disease. Design: A total of 176 patients with CKD [glomerular filtration rate (GFR) 50.3 ± 29.1 mL min-1] were recruited and followed for up to 84 months. Lipid profile, metabolic status and kidney function were evaluated at predetermined times. Age-matched control subjects were selected from ...
Effects of Red Grape Juice Consumption on High Density Lipoprotein-Cholesterol, Apolipoprotein AI, Apolipoprotein B and Homocysteine in Healthy Human Volunteers
TY - JOUR. T1 - Effectiveness of low-dose crystalline nicotinic acid in men with low high-density lipoprotein cholesterol levels. AU - Martin-Jadraque, Raquel. AU - Tato, Federico. AU - Mostaza, Jose M.. AU - Vega, Gloria L. AU - Grundy, Scott M. PY - 1996/5/27. Y1 - 1996/5/27. N2 - Background: Hypoalphalipoproteinemia (low serum concentration of high-density lipoprotein cholesterol [HDL-C]) is a common pattern of dyslipidemia associated with coronary heart disease. High doses of nicotinic acid effectively raise HDL-C levels in this condition, but they are commonly accompanied by side effects. The efficacy of low doses of nicotinic acid that may produce fewer side effects has not been adequately studied. Objective: To determine the effects of low-dose nicotinic acid on HDL-C levels in patients with hypoalphalipoproteinemia. Methods: Forty-four men with low HDL-C levels (, 1.03 mmol/L [,40 mg/dL]) entered the study. Twenty-four patients otherwise had normal lipid levels, and 20 were moderately ...
TY - JOUR. T1 - High-density lipoprotein cholesterol. T2 - a potential therapeutic target for prevention of coronary artery disease.. AU - Chernobelsky, Alexander. AU - Ashen, M. Dominique. AU - Blumenthal, Roger S.. AU - Coplan, Neil L.. PY - 2007/1/1. Y1 - 2007/1/1. N2 - High-density lipoprotein cholesterol has an important role in the pathophysiology of coronary artery disease. High-density lipoprotein cholesterol is becoming an increasingly important prognostic and therapeutic target. The purpose of this paper is to review the biochemical pathways involved in reverse cholesterol transport and to discuss potential, clinically based high-density lipoprotein therapies that may contribute to reduction in risk of atherosclerosis.. AB - High-density lipoprotein cholesterol has an important role in the pathophysiology of coronary artery disease. High-density lipoprotein cholesterol is becoming an increasingly important prognostic and therapeutic target. The purpose of this paper is to review the ...
The effect of a new potent choleretic drug (Febuprol) on lipid composition and cholesterol nucleation time in gallbladder bile was studied in 8 patients with cholesterol gallstones. Nine untreated patients with cholesterol cholecystolithiasis and functioning gallbladder served as controls. Under Febuprol treatment (3 X 100 mg for 6-10 days) mean concentrations of total bile acids (125.4 vs. 59.5 mmol/l), phospholipids (46.1 vs. 25.6 mmol/l) and total lipids (10.4 vs. 5.9 g/dl) were significantly higher (p less than 0.01) than in controls. No significant difference between both groups was calculated for the mean values of cholesterol (17.8 vs. 13.3 mmol/l), cholesterol saturation index (1.5 vs. 2.1) and cholesterol nucleation time (2.1 vs. 2.6 days). Our findings are compatible with a choleretic effect of Febuprol but no alteration of the rapid cholesterol crystallisation in gallbladder bile of patients with cholesterol gallstones was found. ...