The authors evaluated the contributions of nine genetic (G) variants (selected from 275 single nucleotide polymorphisms in 11 reverse cholesterol transport pathway genes), five environmental (E) factors (selected from 10), and G × G, E × E, and G × E interactions in explaining population variance of blood lipid concentrations. Total cholesterol, triglycerides, and high density lipoprotein (HDL) cholesterol were measured, and low density lipoprotein (LDL) cholesterol and HDL cholesterol/LDL cholesterol ratio were calculated in a population-based random sample of 1,543 men and women in Geneva, Switzerland, aged 35-74 years in 1999-2001. Explained variances (R2) for HDL cholesterol/LDL cholesterol ratio, HDL cholesterol, and LDL cholesterol, respectively, were 34%, 33%, and 19%, decomposed into main effects of G (6%, 4%, and 5%) and E (25%, 28%, and 11%), with just 3%, 2%, and 3% due to G × G, E × E, and G × E interactions, respectively. Risk factor clustering was only moderate: 70% of study ...
Supplements of a highly purified lipase were given with fat test meals to human subjects and dogs in order to determine the effect on blood lipid levels. The optical density and hence lipid levels of the blood plasmas were lowered in all subjects when sufficient lipase was ingested. The total esterified fatty acid and triglyceride determinations confirmed this measurement of the decrease acid and triglyceride determinations confirmed this measurement of the decrease in blood lipid levels. Human subjects with lowered fasting O.D. values and E.F.A. appeared to require more lipase to obtain this effect. The blood cholesterol values of normal subjects were not affected, nor was that of a hyperlipemic subject who ingested the lipase for over a four week test period. In all human subjects, the serum lipase values were elevated when the blood lipid levels were lowered. The association of elevated blood lipase levels with decreased blood lipids suggest the possibility of a lipolytic action in the
Dried blood spot (DBS) analysis is a convenient way to collect blood samples with several advantages over conventional blood collection methods. DBS has gained popularity in fields such as newborn screening, preclinical studies, and therapeutic drug monitoring [2, 4, 7, 8]. DBS coupled with LC-MS/MS system provides the capacity to analyze samples in a high throughput manner once coupled to robust analytical methods. Lipidomics analysis of whole blood, which is comprised of thousands of diverse lipid molecular species, is directly linked to an individuals physiological, nutritional and health status [14, 35]. In this study, we combined DBS collection with high-resolution MS/MSALL shotgun lipidomics analysis to analyze the blood lipidome. We demonstrate in one DBS spot, several lipid classes and more than 1,200 lipid species were identified and quantified.. Direct infusion-based MS shotgun lipidomics provides comprehensive profiling and quantitation of lipid species from organic extracts of ...
Background: Previous data on the possible effects of age and gender on serum lipids profile of elderly people showed considerable debates. Aim: to eva..
Lipidomics is the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The huge diversity of native lipids and their modifications make lipidomic analyses challenging. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography. Although shotgun lipidomics allows for high-throughput analysis, low-abundant lipid species are not detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. In this review, we will discuss the potential of lipidomics for cardiovascular research. To date, cardiovascular research predominantly focuses on the role of lipid classes rather than molecular entities. An in-depth knowledge about the molecular lipid species that contribute to the pathophysiology of cardiovascular
Background Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a biomarker. The aim of this study is to identify lipid molecules from hundreds plasma apparent lipid species as biomarkers for diagnosis of prostate cancer. Methodology/Principal Findings Using lipidomics, lipid profiling of 390 individual apparent lipid species was performed on 141 plasma samples from 105 patients with prostate cancer and 36 male controls. High throughput data generated from lipidomics were analyzed using bioinformatic and statistical methods. From 390 apparent lipid species, 35 species were demonstrated to have potential in differentiation of prostate cancer. Within the 35 species, 12 were identified as individual plasma lipid biomarkers for diagnosis of prostate cancer with a sensitivity above 80%, specificity above 50% and accuracy above 80%.
Lipid profile or lipid panel is a panel of blood tests that serves as an initial broad medical screening tool for abnormalities in lipids, such as cholesterol and triglycerides. The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases. Lipid panels are commonly ordered as part of a physical exam, along with other panels such as the complete blood count (CBC) and basic metabolic panel (BMP). The lipid profile typically includes: Low-density lipoprotein (LDL) High-density lipoprotein (HDL) Triglycerides Total cholesterol Using these values, a laboratory may also calculate: Very low-density lipoprotein (VLDL) Cholesterol:HDL ratio The lipid profile tests are of 7 types: Total lipids Serum total cholesterol serum HDL cholesterol Total cholesterol/HDL cholesterol ratio Serum triglycerides serum Phospholipids Electrophoretic fractionation to determination percentage of (a) ...
Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids.. Methods: Participants from the GLACIER Study (N-max = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms;replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (Delta TC) and triglycerides (Delta TG). Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; N-max = 8263 participants) were used for replication. We conducted an in silico look-up for association with coronary artery disease (CAD) in the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAMplusC4D) Consortium (N similar to 190 000) and functional annotation for the top ranking variants.. Results: In total, 956 ...
This report presents an analysis of data resulting from a lipidomics experiment. The experiment sought to determine the changes in the lipidome of big bluestem prairie grass when exposed to stressors. The two stressors were drought (versus a watered condition) and a rust infection (versus no infection), and were whole plot treatments arranged in a 2 by 2 factorial. A split plot treatment factor was the position on a sampled leaf (top half versus bottom half). In addition, samples were analyzed at different times, representing a blocking factor. A total of 110 samples were used and, for each sample, concentrations of 137 lipids were obtained. Many lipids were not detected for certain samples and, in some cases, a lipid was not detected in most samples. Thus, each lipid was analyzed separately using a modeling strategy that involved a combination of mixed effects linear models and a categorical analysis technique, with the latter used for certain lipids to determine if a pattern of observed zeros ...
Background: Inactivity is a leading contributor to chronic health problems. Physical activity (PA) is an important element in maintaining the health and functional ability in the population and has favorable effects on lipid profile in adults. Here, we examined the effects of pedometer-based PA (step/day ) in healthy middle age men. Methods: ...
Previous studies have suggested that whey supplementation may have beneficial effects on lipid profiles, although results were inconsistent. A literature search was performed in March 2015 for randomized controlled trials observing the effects of whey protein and its derivatives on circulating levels of triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). A meta-analysis was subsequently conducted. The meta-analysis results of 13 trials showed that whey supplementation significantly reduced the circulating TG level by 0.11 mmol/l (95% CI: -0.21, 0 mmol/l), whereas the whey protein had no effects on circulating TC (-0.11 mmol/l, 95% CI: -0.27, 0.05 mmol/l), LDL-C (-0.08 mmol/l, 95% CI: -0.23, 0.07 mmol/l) and HDL-C (0.01 mmol/l, 95% CI: -0.04, 0.05 mmol/l). Subgroup analysis showed that significant TG reduction disappeared in participants with low body mass index, low supplemental whey dose or under exercise ...
Background and Aim: Hyperlipidemia, particularly hypercholesterolemia, is one of the major risk factors in cardiovascular diseases. Egg yolk is one of the richest sources of dietary cholesterol in human nutrition. Because egg yolk has relative high cholesterol, we wish to investigate the effect of consuming regular eggs on serum lipid ...
Advances in single cell genomics and transcriptomics have shown that at tissue level there is complex cellular heterogeneity. To understand the effect of this inter-cell heterogeneity on metabolism, it is essential to develop a single cell lipid profiling approach that allows the measurement of lipids in large numbers of single cells from a population. This will provide a functional readout of cell activity and membrane structure. Using liquid extraction surface analysis coupled with high-resolution mass spectrometry we have developed a high-throughput method for untargeted single cell lipid profiling. This technological advance highlighted the importance of cellular heterogeneity in the functional metabolism of individual human dopamine neurons, suggesting that A53T alpha-synuclein (SNCA) mutant neurons have impaired membrane function. These results demonstrate that this single cell lipid profiling platform can provide robust data that will expand the frontiers in biomedical research.. ...
Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimers disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (C) ...
TY - JOUR. T1 - Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c. AU - Dong, Qingming. AU - Majumdar, Gipsy. AU - OMeally, Robert N.. AU - Cole, Robert N.. AU - Elam, Marshall B.. AU - Raghow, Rajendra. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Insulin stimulates de novo lipid synthesis in the liver and in cultured hepatocytes via its ability to activate sterol regulatory element-binding protein 1c (SREBP-1c). Although PI3K-AKT-mTORC1-p70S6K-signaling kinases are known to drive feed-forward expression of SREBP-1c, the identity of the phosphorylated amino acid residue(s) putatively involved in insulin-stimulated de novo lipogenesis remains elusive. We obtained in silico and mass spectrometry evidence, that was combined with siRNA strategies, to discover that insulin-induced phosphorylation of serine 418, serine 419, and serine 422 in rat SREBP-1c was most likely mediated by p70S6 kinase. Here, for the first time, we show that ...
Background: Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, but the mechanism for this risk remains unclear. Complicating this association, reducing serum homocysteine (Hcy) has not been shown to decrease cardiovascular disease events in randomized controlled trials. This study aims to examine the relationship between Hcy and several lipid measures.. Methods: Our analyses included a subset of 18,297 U.S. adults from the Very Large Database of Lipids, who had an extended lipid panel by density gradient ultracentrifugation, which included direct measurement of triglycerides (TG), and the cholesterol concentration of low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, very low-density lipoprotein (VLDL-C), and remnant-lipoprotein cholesterol (RLP-C: IDL-C + VLDL3-C). Additional measurements were levels of Hcy, hemoglobin A1c (HbA1c), insulin, creatinine, and blood urea nitrogen (BUN). Subjects were categorized into Hcy quartiles. Linear ...
This is calculation with bound lipids. Acyl chains of two lipids were modelled. Calculated hydrocarbon boundary of the lipid bilayer corresponds to the carbonyl groups of the bound lipid. Depending on conformations of bound lipids, the protein can penetrate deeper by ~2 A. Results for the dimer without bound lipids are exactly the same as for lipid-free EEA1 monomer (1hyi). Transfer energy was calculated without contribution from the bound lipid ...
The presentations reflected the early development of LipidomicNet, the European Union Framework VII project focused on the structure of lipid droplets and their function in human health and disease that kicked off just last year. Lipid droplet formation is a hallmark of energy-overload metabolic diseases that are a major heath concern. One goal of LipidomicNet is to integrate lipid structure profiles with proteome and transcriptome analysis to reveal the interrelationship between gene expression and lipid droplet formation.. The project also manages the LipidomicNetWiki (www.lipidomicnet.org), in close collaboration with LIPID Metabolites and Pathways Strategy (LIPID MAPS) and Lipid Bank-Japan. One hope is that those investigators who bump into lipid metabolism in their work will take advantage of the LipidomicsWiki to help sort out the cellular responses to metabolic stress.. All members of the Lipidomics Expertise Platform are allowed to edit and add content to LipidomicNet-Wiki, so I ...
Effect of Ledebouriella seseloides Extracts on Lipid Parameters in Ovariectomized Rats - ALP;collagen;Ledebouriella seseloides;lipid parameters;ovariectomized rats;
Highlights: • Lipid in municipal biomass would not inhibited the anaerobic digestion process. • A lipid concentration of 65% of total VS was the inhibition concentration. • The amount of Brevibacterium decreased with the increasing of the lipid contents. • Long chain fatty acids stacked on the methanogenic bacteria and blocked the mass transfer process. - Abstract: The influence of the lipid concentration on the anaerobic co-digestion of municipal biomass waste and waste-activated sludge was assessed by biochemical methane potential (BMP) tests and by bench-scale tests in a mesophilic semi-continuous stirred tank reactor. The effect of increasing the volatile solid (VS) concentration of lipid from 0% to 75% was investigated. BMP tests showed that lipids in municipal biomass waste could enhance the methane production. The results of bench-scale tests showed that a lipids concentration of 65% of total VS was the inhibition concentration. Methane yields increased with increasing lipid ...
article{bcb56acf-af8b-4795-9113-593c8f47c227, abstract = {Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East ...
The study of lipid transfer between lipid membranes is of great interest for the fundamental understanding of this complex and important process and, furthermore, for providing a new avenue for the in situ modification of supported lipid bilayers (SLBs). SLBs are conveniently formed by vesicle spreading onto a solid support, but this method is limited to conditions (i.e., combination of vesicle lipid composition, surface chemical properties, and buffer) such that the vesicles break spontaneously upon adsorption to the surface. Many SLB compositions are not accessible by this approach. In the present study, we give an example of how lipid transfer can be made use of to form lipid layers with striking new features, notably with respect to stability. After lipid transfer between negatively charged POPS small unilamellar vesicles and a positively charged POEPC SLB on TiO2, an SLB is obtained, which, upon exposure to SDS, leaves behind a lipid monolayer. It is shown how this monolayer can be used for
We found that in youth with type 1 diabetes and relatively short disease duration (mean 4.2 years) mean lipid levels and prevalence of lipid abnormalities are substantially influenced by glycemic control. Youth with type 1 diabetes and optimal A1C levels have lipid profiles that are similar (total and LDL cholesterol) or even less atherogenic (HDL cholesterol, triglyceride, and triglyceride-to-HDL ratio) than those observed in nondiabetic youth. In contrast, youth with type 1 diabetes and suboptimal glycemic control have higher standard lipid levels and prevalence of lipid abnormalities (total cholesterol, LDL cholesterol, and non-HDL cholesterol) than nondiabetic youth. Moreover, youth with type 1 diabetes have significantly elevated apoB levels and more small, dense LDL particles than nondiabetic youth, regardless of glycemic control. We also found that the most frequent lipid abnormalities in youth with type 1 diabetes compared with nondiabetic control subjects are elevated apoB levels and an ...
Previous studies have suggested that whey supplementation may have beneficial effects on lipid profiles, although results were inconsistent. A literature search was performed in March 2015 for randomized controlled trials observing the effects of whey protein and its derivatives on circulating level …
The effects of elevated blood lipid concentrations on cardiovascular mortality and morbidity are reviewed, with particular emphasis on how high fat diets and antihypertensive drugs can influence the...
Lipid-based diseases are a growing and expensive challenge to health care systems. As a population ages, chronic conditions associated with aging such as cardiovascular disease, neurodegenerative disorders, and metabolic disorders take increasing tolls in terms of morbidity and mortality. Oxidation of lipids and lipid metabolites has been linked to disorders of aging like osteoporosis and vascular calcification. Additionally, research is now trying to explain how dysregulations in lipid metabolism may underlie diseases such as Alzheimers, cancer, and asthma. Lipid synthesis pathways, such as the methyl-Derythritol 4-phosphate (MEP) pathway of isoprenoid synthesis, are being investigated as potential targets for antibacterial therapies and drug targets. As changes in lipid profiles can mark developmental stages or more ominously, pathological states, there is great potential for the use of lipids as biomarkers. Experimental quantification of the levels of lipids and lipid metabolites is ...
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research - have not changed since previous editions.. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry.. An introductory chapter summarizes the types of lipids covered and their identification and provides ...
Aim: To investigate relationship between serum TSH and lipid parameters in subjects with different levels of TSH. Study Design: Cross-sectional study. Place and Duration of Study: Clinical Biochemistry Department of Kasturba Medical College, Hospital Mangalore, between January 2014 to June 2014. Methodology: 348 subjects were screened of which 194 were selected. Lipid parameters, TSH, T3, T4 and glycemic status were determined. Association between TSH and serum lipids were studied by categorizing subjects into three groups based on their thyroid status. Group 1 [TSH= 0.27-2.5 mIU/L], Group 2 [TSH= 2.6-4.12 mIU/L] and Group 3 [TSH= 4.13-9.9mIU/L].Statistical analysis was performed by ANOVA followed by Tukeys multiple comparison test. The relationships between TSH and different parameters were evaluated by Pearsons correlation analysis. Results: TSH showed a significant positive linear correlation with total cholesterol (r=0.288; P = 0.001), Triglycerides (r=0.129; P=0.016), LDL cholesterol ...
TY - JOUR. T1 - Effect of an empowerment-based nutrition promotion program on food consumption and serum lipid levels in hyperlipidemic Thai elderly. AU - Boonyasopun, Umaporn. AU - Aree, Patcharaporn. AU - Avant, Kay C.. PY - 2008/6/1. Y1 - 2008/6/1. N2 - This quasi-experimental study examined the effects of an empowerment-based nutrition promotion program on food consumption and serum lipid levels among hyperlipidemic Thai elderly. Fifty-six experimental subjects received the program; 48 control subjects maintained their habitual lifestyle. The statistical methods used were the t-test, Z-test, and χ2/Fishers exact test. After the program, the consumption of high saturated fat, cholesterol, and simple sugar diets was significantly lower for the experimental group than for the control group. The percentage change of the serum total cholesterol of the experimental subjects was significantly higher than that of the control subjects. The number of experimental subjects that changed from ...
They include low-density lipoproteins (LDL), high-density lipoproteins (HDL) and triglycerides. 22-8). Dietary lipids and metabolic syndrome MS, also known as syndrome X, or the insulin resistance syndrome, is a combination of medical disorders comprising an array of metabolic risk factors including central obesity, Plasma lipids are usually measured after a 12-hour fast due to postprandial fluctuations of triglycerides. Exclusion of secondary causes of lipid disorders (see earlier discussion) is important. Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.In animals, these fats are obtained from food or are synthesized by the liver. 2 Lipid digestion Micelle structure. Xanthelasmas are often treated with topical trichloroacetic acid, electrodesiccation, laser therapy, and excision, but recurrences may occur. ...
A lipid panel is a safe procedure with minimal risks. Some kids might feel faint or lightheaded from the test. A few kids and teens have a strong fear of needles. If your child is anxious, talk with the doctor before the test about ways to make the procedure easier.. A small bruise or mild soreness around the blood test site is common and can last for a few days. Get medical care for your child if the discomfort gets worse or lasts longer. If you have questions about the lipid panel, speak with your doctor or the health professional doing the blood draw.. Back To Top. ...
Awhile ago, TheFatNurse noticed something strange while reviewing some Lipid panels. Normally, when you receive a lab result, a reference range is given and any numbers above or below the reference range is flagged. What was strange about some of these lipid panels was the lack of flags for patient numbers that were clearly in…
Lipids constitute a significant group of biological metabolites and the building blocks of all cell membranes. The abundance and stoichiometries of different lipid species are known to vary across the lifespan and metabolic state, yet the functional effects of these changes have been challenging to understand. Here we review the potentially powerful intersection of lipid metabolism, which determines membrane composition, and aging. We first introduce several key lipid classes that are associated with aging and aging-related disease, where they are found in organisms, and how they act on membrane structure and function. Instead of neutral lipids, which have primary roles in energy storage and homeostasis, we review known functions for polar lipids that control the physicochemical properties of cell membranes. We then focus on aging processes in the central nervous system (CNS), which is enriched in lipids and is highly dependent on membrane structure for function. Recent studies show how lipids act not
Lipids and Lipid-like Molecules are a superclass of organic compounds, including fatty acids, fatty acid derivatives, and substances related biosynthetically or functionally to these compounds
Am J Clin Nutr. 1998 Dec;68(6 Suppl):1375S-1379S. Clinical Trial; Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Govt
Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skins external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance. -Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids -Improves the look of skin fullness, texture, and pore appearance -Improves the appearance of skin evenness and overall radiance -Unique lipid stabilization system in a lightweight and fast-absorbing texture -Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below) -Paraben-, and dye-free -Ideal for aging, normal, and dry skin types
Shotgun lipidomics enables the detection of lipids from theoretically all kinds of substrate, provided that extraction and processing procedures are adapted, to ensure good coverage and reproducible quantification of the lipidome. The quantification of lipids from Adipose tissue (AT) is particularly challenging due to the predominance of triacylglycerides, which elicit high ion suppression of the remaining lipid classes. We generated this data by applying a new and validated method for shotgun lipidomics of AT, which tailors the lipid extraction procedure to the target specimen. In particular, we analysed three AT types (brown - BAT; gonadal - GAT; inguinal subcutaneous - SAT) from 10 lean (chow diet - CD) and 10 obese (high fat diet - HFD) mice. We observed tissue-specific and diet-related differences, with Brown AT exhibiting a distinct lipidomic profile with the greatest lipid class diversity and responding to high-fat diet by altering its lipid composition, so that it becomes more similar to
This image by first author Sarah Hancock shows an iris surrounded by the lipid she and colleagues in the Blanksby and Mitchell labs characterized by mass spectronomy.Journal of Lipid Research. But water alone isnt enough to keep the eye from drying out. A microscopically thin film of oils known as the lipid layer protects the tear film from evaporating. In the August issue of the Journal of Lipid Research, a group of Australian researchers reports the structure of a key long-chain lipid in this layer. Their finding may be used to improve treatments for dry eye.. Although the long-chain lipids in question make up just 5 percent of the tear-film lipid layer, they play an important role in vision. Without them, earlier studies showed, the lipid layer would resemble an oil slick atop a puddle.. This clearly wouldnt be satisfactory for you to look through, said Stephen Blanksby, a professor at the Queensland University of Technology who led the research team in this study.. Blanksby saw the ...
The role of lipid biomarkers in assessing the risk of cancer has not been studied in detail. However, lipid metabolism has now been accepted as a major metabolic pathway involved in many aspects of cancer cell biology (9). In this context, the contribution of dietary factors, such as different types of fatty acids, carbohydrates, and added sugars may be of importance. Hence, it is likely that future therapeutic strategies for cancer will include dietary regimes. Blood lipids and lipoproteins may influence the risk of cancer through insulin resistance, inflammation, and oxidative stress (10 ...
Well I went and ordered up some blood work the other day and results began coming in today. While my past Lipid Panel was blogged right here, this is the new one. The past one shows a total serum cholesterol of almost the same (219), while I had an HDL of 106 and a calculated LDL of 104. You know what I think of calculated LDL. Well, this isnt a NMR LipoProfile or a VAP. Its the best I can get from Kaiser and it purports to be a direct measurement of LDL (though not a particle count). However, if accurate, I would expect my particle count to be 660-669 nmol/L, which would be considered optimal in terms of particle number (| 1000). Size is something we can only guess on, but my HDLs make it clear that Im pretty high in fat consumption and thats highly associated with mostly large fluffy LDL and little to no small dense LDL. Its interesting to note that if you look at Patriks NMR LipoProfile and assume my LDL Direct to be accurate (for now -- I am still going to do an NMR as well), then calculated
Description: Lipid profile as such sounds so simple but the simple measurement of lipid profile in subjects gives massive information about the progression of diseases and still many things about lipids yet to be unveiled. Daily new concepts are coined based on the ongoing researches. This book encompasses the diagnostic and prognostic importance of lipid profile assay. Here the author establishes the importance of lipid assay and it covers some of the research based on lipids in Normolipidemic AMI patients, AIDS patients and also multicenter studies. It was once believed that if one is Normolipidemic than the risk of AMI is lowered but the trends of Hyperlipidemia always associated with AMI have changed. In this book the author shares his experience working with Normolipidemic AMI patients. The research is based on stratification of risk factors in these patients, where the author approaches to elucidate the various risk factors associated with Normolipidemic AMI patients. This book would ...
Study aim: To determine the effects of indoor cycling training combined with restricted diet, lasting 12 weeks, on serum lipid concentrations in obese women.Material and methods: Twenty women aged 23.8 ± 3.6 years were randomly assigned into two groups: control (C) and experimental (E), the latter subjected to indoor cycling at various loads, 3 sessions weekly, every session lasting 45 min, combined with restricted diet (about 1200 kcal daily) for 12 weeks. The following variables were recorded: body height and mass, BMI, relative body fat content (from 7 skinfolds), fat-free mass, triglycerides, cholesterol and lipoproteins (HDL, LDL, VLDL).Results: Significant increase in HDL and significant decreases in all other variables (except body height) were noted only in the experimental group.Conclusions: Indoor cycling associated with restricted diet is an excellent option in controlling obesity and serum lipids ...
Colleagues, We are delighted to launch the new LIPID MAPS Lipidomics Gateway, funded by the Wellcome Trust and jointly hosted by Cardiff University, Babraham Institute and University of California San Diego (UCSD). These are exciting times as we move forward with Phase II of this global project. Our new site provides easier access to the most utilized areas: Lipid Classification System; Structure Database; and Tools. Curation has restarted, with over 500+ new lipid molecules added in the last few months with many now featured in our structure drawing tools. Back in 2016, we asked you what you would like to see on LIPID MAPS, and in response we provide new features including raw MS data deposition in collaboration with Metabolomics Workbench (which already hosts over 500 lipidomics studies), and statistical analysis tools. We include a contact form for you to get in touch with us and provide feedback. We also have a registration facility, and will be using this as a mailing list in the coming ...
These experiments were designed to study the topography of lipid deposition in the stenotic aorta of hypercholesterolemic rats, and to correlate it with flow conditions and intimal stresses and strains studied in a scale biophysical model and in a computer model. A 69% +/- 5% stenosis was produced with a U-shaped metal clip. One month to 8 months later, the aorta was studied en face by light microscopy after fixation and lipid staining. The intima in the throat of the stenosis was almost completely free of lipid, whereas symmetric lipid deposits occurred as bands just above and especially just below the stenosis; elsewhere lipid deposits appeared to be random. The flow data obtained from the scale model showed that the intima in the throat of the stenosis was subjected to an increase of as much as 20 times in shear stress, whereas the lipid deposits just above and just below the stenosis were associated with asymmetric flow conditions: the proximal area corresponded to a region of rapidly increasing
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Use the Lipid Panel with Total Cholesterol:HDL Ration to monitor your cholesterol. With Request A Test, ordering your own lab testing couldnt be easier or more convenient. Order your lab tests, give your sample, get results. Call or go online to order today.
To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL)
Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individuals were performed to identify genetic variants that modify the effect of loop or thiazide diuretic use on blood lipid concentrations. Both longitudinal and cross sectional data were used to compute cohort-specific interaction results, which were then combined through meta-analysis in each ancestry. These ancestry-specific results were further combined through trans-ancestry meta-analysis. Analysis of EA data identified two genome-wide significant (p , 5 × 10−8) loci with single nucleotide variant ...
TY - JOUR. T1 - Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event. AU - Weinstock-Guttman, Bianca. AU - Zivadinov, Robert. AU - Horakova, Dana. AU - Havrdova, Eva. AU - Qu, Jun. AU - Shyh, Grace. AU - Lakota, Elizabeth. AU - OConnor, Kerri. AU - Badgett, Darlene. AU - Tamaño-Blanco, Miriam. AU - Tyblova, Michaela. AU - Hussein, Sara. AU - Bergsland, Niels. AU - Willis, Laura. AU - Krasensky, Jan. AU - Vaneckova, Manuela. AU - Seidl, Zdenek. AU - Ramanathan, Murali. PY - 2013/11. Y1 - 2013/11. N2 - Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (≥2 brain MRI lesions and ≥2 ...
This blood test checks the levels of cholesterol in your body. A lipid panel will show the levels of your total cholesterol, your LDL (