Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this...
Sigma-Aldrich offers abstracts and full-text articles by [Tao Wu, Anqi Guo, Qingyu Shu, Yangjian Qi, Ying Kong, Zhiping Sun, Shumin Sun, Zhengwei Fu].
Lipid disorders are common among patients with HIV and tend to worsen with potent antiretroviral therapy. Lipid-lowering drugs are not always effective, and few data address interactions between antiretroviral drugs and lipid-lowering agents. Additional agents for the treatment of lipid metabolism disorders in HIV-infected patients are needed. Niacin, which is highly effective for similar lipid disorders in the general population, may be effective in treating lipid disorders in patients with HIV.. This 48-week study consists of two steps. In Step 1, patients will begin a lipid-lowering diet and exercise regimen that will continue throughout the study. After 4 weeks on the regimen, patients will enter Step 2 of the study and will begin extended-release niacin therapy. During Step 2, niacin will be dose-escalated every 4 to 6 weeks over a 16-week period. At Weeks 14 and 20, the niacin dose will be determined by blood fat levels. Patients will remain on the dose set at Week 20 for the remainder for ...
Lipid metabolism balance plays a vital role in maintaining normal levels of sterols, triglycerides, and free fatty acids (FFA). Inhibiting FFA-induced lipotoxicity is considered a highly potential treatment for non-alcoholic fatty liver disease (NAFLD) and other lipid metabolism diseases. Punicalagin (PU), a pomegranate-derived polyphenol, has been found to effectively regulate lipid metabolism and prevent fatty liver, cardiovascular and other chronic diseases caused by lipid metabolism disorders. In the present study, we found that PU protects HepG2 cells from palmitic acid (PA)-induced lipapoptosis. Silent information regulator 1 (SIRT1) plays a key role in protecting against lipapoptosis in HepG2 cells. Knockdown of SIRT1 significantly diminished the protective effect of PU. Besides, PU could be able to reactivate weakened autophagy and inhibit PA-induced ER stress. Our findings supported that PU can effectively attenuate FFA-induced lipotoxicity via activating SIRT1/autophagy and inhibiting ER
This page includes the following topics and synonyms: Disorders of Energy Metabolism, Glycogen Storage Disease, Disorder of Carbohydrate Metabolism, Lipid Metabolism Disorders.
PhosChol for Heart and Lipoprortein metabolism: Lipid metabolism disorders, in particular, disturbances of lipoprotein metabolism, (which can be subsumed under the term dyslipoproteinemia) constitute an important risk factor in the pathogenesis of atheros
A lipid metabolism disorder characterized by elevated triglyceride levels as a result of excess hepatic production of VLDL or heterozygous LPL deficiency.
... majors in treating diabetes, diabetic nephropathy, diabetic peripheral neuropathy, diabetic foot, diabetes and cardiovascular disease, diabetic retinopathy, diabetes lipid metabolism disorders and skin disease etc. Our c
Objective To investigate the effects of combination treatment with Probucol plus Aspirin on the prevention of steroid-induced avascular necrosis of femoral head(ANFH) in rabbits and to investigate the pathogenesis of ANFH. Methods Rabbits were divided randomly into three groups such as model group, treatment group and normal group. Before and after the experiment, serum lipid and prothrombin time (PT) were tested. In the 4th and 6th weeks of dexamethasone administration, the histopathological changes were observed with radiography, light microscopy and transmission electron microscopy. Results The incidence of osteonecrosis in the model group was 58%; the incidence of osteonecrosis in the treatment group(7%) was significantly lower than in the model group and no osteonecrosis was observed in the normal group. Under electron microscopy, osteocytes were found to be degenerative, necrotic and disappeared eventually. Conclusion Lipid metabolism disorder and hypercoagulability are risk factors for
EN] Atherosclerosis is the most prevalent non-infectious disease associated with very high mortality and severe disability. The medical and social significance of atherosclerosis is especially important for our country where the rates of myocardial and cerebral infarctions are extremely high. Up to the late seventies of 20th century, atherogenesis has been regarded as a lipid metabolism disorder. At present, the "response-to- injury" hypothesis is the predominant atherogenesis paradigm, where atherosclerosis is defined as a "protective inflammatory-fibroproliferative response" to various atherogenic stimuli. In spite of the enormous information, the factors, responsible for the origin, the distribution and the activation of atherosclerotic lesions remain incompletely clarified. The role of infectious and immune mechanisms, the involvement of the adventitia and its interactions with media and intima are not thoroughly explored. Atherosclerotic changes in the three layers of aorta, coronary and ...
Xanthelasma is a skin condition that causes Xanthomas, which are skin lesions caused by the accumulation of fat in macrophage immune cells in the skin and more rarely in the layer of fat under the skin. Some types of xanthoma are indicative of lipid metabolism disorders (e.g. hyperlipidaemia or high blood fats), where they may be associated with increased risk of coronary artery heart disease and occasionally with pancreatitis. The most common type of Xanthomas occur as soft yellow velvety lesions on the upper and lower eyelids that start as a small bump and grow larger over a few months to years. They can be treated with radiosurgery, very strong acid such as Trichloracetic acid or with laser resurfacing. ...
This report examines the Bone and Mineral Metabolism Disorders Treatment market standing and opportunity of global plus major regions, from plans of manufacturers, regions, product types and end industries; this report investigates the best manufacturers in global and major regions and splits the Bone and Mineral Metabolism Disorders Treatment market by product type and applications/end…
The thesis is drafted up on 120 pages, being classically divided in compartments: introduction, 4 chapters, conclusions and practical recommendations, bibliography from 181 sources, 21 annexes, includes 27 tables and 19 figures. The got results are published in 25 scientific works, including one guideline on 88 pages. Goal of research: Elaboration of a complex program of individual therapeutic and social management of children that are suffering from Phenylalanine (Phe) metabolism disorders, including Phenylketonuria (PKU). Objectives of research: The investigation of free amino acids spectrum in blood and urine as well as of chemical parameters to children with PKU and with Phenylalaninuria till and after application of metabolic correction measures; specification and completion of diagnosis criteria of Phenylalaninuria as persistent disorders of Phe metabolism; argumentation of drug treatment necessity for metabolism correction in the completion of specific dietetic regime; quantification of ...
Metabolism disorders have to do with the way your body turns food into energy. Our endocrinologists at WTMF in Fremont provide advanced testing & treatment.
Encyclopedia article on this rare autosomal inherited lipid metabolic disorder. Includes epidemiology, signs and symptoms, pathogenesis and treatment. ...
Cholesterol influences the health of our hearts and blood vessels. Conventional treatment attempts to reduce the level of "bad" cholesterol, LDL cholesterol, in the blood plasma. The opposite approach, which involves increasing the concentration of "good" HDL cholesterol using nicotinic acid, has proven unpopular among patients up to now. The reason for this is that treatment with nicotinic acid has an unpleasant but harmless side-effect: the drug makes patients turn quite red in the face. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered the mechanism behind this effect, which is known as flushing. This will enable the development of flush inhibitors and thereby the more effective prevention of cardiovascular diseases. (Journal of Clinical Investigation, online version: July 26, 2010). In addition to a healthy lifestyle, the treatment of lipid metabolic disorders is one of the important measures used in the prevention of cardio-vascular ...
UNSW research has highlighted a link between childhood obesity and a mothers diet before and during pregnancy. The work in animals proves that overweight expectant mothers are more likely to have babies with more body fat, who are at greater risk of diabetes and lipid metabolic disorders later in life.. Previous research shows that around 30 percent of women who become pregnant are overweight.. The research, published in the journal Endocrinology, shows obese mother rats fed more milk had pups almost twice as heavy as those born to lean mothers with regular milk consumption at weaning age.. The cafeteria diet used to feed the mother rats is designed to approximate a western diet which people eat everyday at home. It is of high fat content, and palatable with a lot of variety. The research found that the mother rats ate more than double the calories of the control group.. "Maternal obesity and overfeeding early on in life caused significant changes in the chemicals that regulate appetite, which ...
J Am Geriatr Soc. 2013 Jan;61(1):40-5. doi: 10.1111/jgs.12060. Epub 2013 Jan 10. Comparative Study; Research Support, Non-U.S. Govt
You can develop a metabolic disorder if certain organs - for instance, the pancreas or the liver - stop functioning properly. These kinds of disorders can be a result of genetics, a deficiency in a certain hormone or enzyme, consuming too much of certain foods, or a number of other factors.. There are hundreds of genetic metabolic disorders caused by mutations of single genes. These mutations can be passed down through generations of families. According to the National Institutes of Health (NIH), certain racial or ethnic groups are more likely to pass on mutated genes for particular inborn disorders. The most common of these are:. ...
Pediatric metabolic disorders happen when a childs body is not appropriately processing nutrients. Our providers will treat your childs metabolic disorder.
Learn about the causes, symptoms, diagnosis & treatment of Inherited Disorders of Metabolism from the Professional Version of the Merck Manuals.
During a search for cause of my health conditions, I came across this website that shows disorders related to amino acid metabolism. Ive stripped out...
Metabolic acidosis can be caused by various conditions that produce too much acid in the blood, cause the kidneys to excrete too little acid, or cause
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Find out more about lipid disorders symptoms, conditions and the advanced treatments MedStar Washington Hospital Center offers to treat lipid disorders.
Lipid Disorder Treatment Market Analysis, Trends and Forecast. Lipid Disorder Treatment Market Industry Overview, Market Growth, Syndicate Report and Business Research Reports - UK and US
Fibrate Drugs can be effective in treating Lipid Disorders. Learn about Fibrate Drugs, see related evidence, and find other smart treatments for Lipid Disorders at FoundHealth.
Resting pulse rates among pre-teens in the U.K. have increased over the last 30 years, suggesting a decline in overall fitness levels, researchers reported.
Yechiam Ostchega, Ph.D. et al., U.S. Department OF Health and Human Services National Center for Health Statistics Resting Pulse Rate Reference Data for Children, Adolescents, and Adults: United States,1999-2008 ...
In the impact on DKD glucose metabolism, HD may be more beneficial than PD. First, dialysis can reduce the concentration of plasma insulin to avoid excessive accumulation, long-term dialysis can reduce body weight, remove excess fat, thereby improving insulin resistance, contribute to the normal level of blood glucose regression; Second, the removal of uremic molecules can improve the liver Glycogen gluconeogenesis, can improve the ability of peripheral tissue sugar uptake, help to improve glucose metabolism disorders. The PD treatment of conventional use of peritoneal dialysis fluid, to a certain extent, increased insulin resistance, and bring a new series of metabolic disorders. Therefore, diabetic patients with PD, you must actively control blood sugar. ...
tissue hypoxia with impaired energy exchange;. - disorders of hemodynamics and circulation;. - systemic inflammatory reaction;. - endotoxicosis;. - disorders of hemostasis;. - disorders of the neurotransmitter balance. Clinically, these syndromes are realized by the appearance of cerebral, diffuse and focal neurological symptoms, primarily disorders of consciousness of various depths, respiratory disorders, disorders of local and systemic blood flow, coagulation and rheological properties of blood, secondary purulent-septic complications, tissue metabolism disorders in the form of stress-protective ulcersgastrointestinal tract( GIT), pressure sores, etc. The primary triggers of the pathogenetic cascade in acute stroke are always hypoxia and ischemia, which are severe and early affecting cerebral structures, highly sensitive to energy exchange disorders, provoked by oxygen and blood flow deficiency. Rapid suppression of regulatory-trophic cerebral influences, in the norm of corrective homeostasis ...
MODEL RELEASED. Diabetic blood test. A medical health care worker uses a glucometer to measure the level of blood glucose in an elderly diabetic woman. The diabetic has had her finger pricked to extract a drop of blood. The blood is placed on a chemically coated strip which activates the digital display of the glucometer. Diabetes mellitus is a carbohydrate metabolism disorder, in which unused sugars accumulate in the blood and urine. It is usually caused by insufficient insulin production by the pancreas. Treatment is is based on a strict diet to control blood sugar, and success can be tested in counselling sessions such as this. Insulin injections may be required. - Stock Image M725/0211
Over the past 20 years, effective treatments for lipid disorders have become available. With the high incidence of coronary artery disease in the developed world, interest in this area has greatly increased and 10% of the UK population now qualify for lipid lowering treatment.
Over the past 20 years, effective treatments for lipid disorders have become available. With the high incidence of coronary artery disease in the developed world, interest in this area has greatly increased and 10% of the UK population now qualify for lipid lowering treatment.
Learn more about Risk Factors for Lipid Disorders at Coliseum Health System Main Page Risk Factors Symptoms ...
Learn more about Risk Factors for Lipid Disorders at Grand Strand Medical Center Main Page Risk Factors Symptoms ...
Akcea Therapeutics’s volanesorsen has been granted a Promising Innovative Medicine designation by the Medicines and Healthcare products Regulatory Agency for the treatment of familial chylomicronaemia syndrome, a rare genetic lipid disorder. - News - PharmaTimes
TY - CHAP. T1 - Endocrine, Metabolic, and Lipid Disorders. AU - Nelson, Richard W. AU - Turnwald, Grant H.. AU - Willard, Michael D.. PY - 2003/11/21. Y1 - 2003/11/21. UR - http://www.scopus.com/inward/record.url?scp=84942612533&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84942612533&partnerID=8YFLogxK. U2 - 10.1016/B0-72-168903-5/50013-6. DO - 10.1016/B0-72-168903-5/50013-6. M3 - Chapter. AN - SCOPUS:84942612533. SN - 9780721689036. SP - 165. EP - 207. BT - Small Animal Clinical Diagnosis by Laboratory Methods. PB - Elsevier Inc.. ER - ...
Learn more about Conditions InDepth: Lipid Disorders at Memorial Hospital Main Page Risk Factors Symptoms ...
Learn more about Conditions InDepth: Lipid Disorders at Memorial Hospital Main Page Risk Factors Symptoms ...
Lipid disorders are important to treat because they can increase risk for heart attack, stroke and other atherosclerotic disease.
Learn more about Reducing Your Risk of Lipid Disorders at Doctors Hospital of Augusta Main Page Risk Factors ...
Learn more about Reducing Your Risk of Lipid Disorders at Doctors Hospital of Augusta Main Page Risk Factors ...
Learn more about Reducing Your Risk of Lipid Disorders at Reston Hospital Center Main Page Risk Factors ...
Learn more about Talking to Your Doctor About Lipid Disorders at Portsmouth Regional Hospital Main Page Risk Factors ...
I was taking Elavil for insomnia and I noticed that my resting pulse shot up after an increase in the Elavil. My resting pulse was 55-80 bpm, it increased to 75-112 bpm. When I was at my old doctors o...
I have a very similiar thing going on ? I am 35 years old . I have not allways taken care of myself . I had blood pressure in around 140/85 to 150/90 .. I have gotten that under control about a month a...
Background and aims: Alterations in carbohydrate metabolism are frequently observed in cirrhosis; to determine the frequency of diabetes mellitus and impaired glucose tolerance in Tunisian cirrhotic patients and identify risk factors. Patients and methods: Cross-sectional study; fasting plasma glucose levels were measured in consecutive patients with cirrhosis. Oral glucose tolerance test was performed if fasting plasma glucose level was normal. Glucose metabolism disorders were then classified as: impaired glucose tolerance and diabetes mellitus. Cirrhotics with glucose metabolism disorder were compared to those without. Results: Seventy-seven patients with cirrhosis were included: 68.8% were diagnosed as having glucose metabolism disorder; diabetes in 42.8% and impaired glucose tolerance in 26%. The tests were able to identify 60.4% of glucose metabolism disorders. Univariate analysis disclosed a higher proportion of female gender (p = 0.04) and more frequent familial history of diabetes mellitus (p =
Berberine is known to improve glucose and lipid metabolism disorders, but it poorly absorbed into the blood stream from the gut. Therefore, the exact underlying mechanism for berberine is still unknown. In this study, we investigated the effect of berberine on glucose metabolism in diabetic rats and tested the hypothesis that berberine acts directly in the terminal ileums. Rats were divided into a control group, diabetic group (DM), low dose of berberine group (BerL) and high dose of berberine group (BerH). Ileum samples were analyzed using a Roche NimbleGen mRNA array, qPCR and immunohistochemistry. We found that 8 weeks of treatment with berberine significantly decreased fasting blood glucose levels. An oral glucose tolerance test (OGTT) showed that blood glucose was significantly reduced in the BerL and BerH groups before and at 30 min, 60 min and 120 min after oral glucose administration. Plasma postprandial glucagon-like peptide-1 (GLP-1) levels were increased in the berberine-treated groups. The