Keratinocytes play an important role in skin irritation. In an attempt to investigate mechanistic bases of human skin irritation response, we recently identified the upregulation by skin irritants of adipose differentiation related protein (ADRP) in reconstituted human epidermis. ADRP is a lipid-storage-droplet-associated protein, governing deposition and release of lipids from droplets. The purpose of this study was to characterize, in a human keratinocyte cell line (NCTC 2544), sodium-dodecyl-sulfate-induced ADRP expression, to identify the biochemical events that lead to ADRP expression, and to understand its function in sodium dodecyl sulfate cytotoxicity. Sodium dodecyl sulfate induced a concentration- and time-related production of ADRP that was associated with lipid droplet accumulation. Lipid accumulation following sodium dodecyl sulfate treatment was due to intracellular redistribution rather than lipid neosynthesis, as indicated by equivalent 14C-oleate and 14C-acetate incorporations. ...
High dietary protein can reduce fat deposition in animal subcutaneous adipose tissue, but little is known about the mechanism. Sixty Wujin pigs of about 15 kg weight were fed either high protein (HP: 18%) or low protein (LP: 14%) diets, and slaughtered at body weights of 30, 60 or 100 kg. Bloods were collected to measure serum parameters. Subcutaneous adipose tissues were sampled for determination of adipocyte size, protein content, lipid metabolism-related gene expression, and enzyme activities. HP significantly reduced adipocyte size, fat meat percentage and backfat thickness, but significantly increased daily gain, lean meat percentage and loin eye area at 60 and 100 kg. Serum free fatty acid and triglyceride concentrations in the HP group were significantly higher than in the LP group. Serum glucose and insulin concentrations were not significantly affected by dietary protein at any body weight. HP significantly reduced gene expression of acetyl CoA carboxylase (ACC), fatty acid synthase (FAS) and
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to ...
Plant lipid metabolism pathways have been extensively studied as increasing plant oil yields is one important goal among researchers. However, the gene expression pattern of lipid metabolism regulating pathways especially in wound-induced callus of Arabidopsis thaliana is still unknown. The use of artificial microRNA retinoblastoma-related (amiRBR) strain allowed for the study of reduced RBR expression effects on lipid accumulation. Although the lipid contents in hormone-induced callus were possibly lower than leaves in wild-type (WT) A. thaliana, wound-induced callus was used to eliminate genetic interferences. Lipid content comparisons on 7-, 14- and 21-day old leaf and callus showed possibly higher lipid content in WT callus, although amiRBR callus contained possibly higher lipid content than its leaves at Day 7. Lipid metabolism genes undergoing cell-fate changes were studied. The mRNA expression of the lipid catabolism genes, acyl-CoA oxidase 1 and 2 (ACX1, ACX2) and multifunctional protein ...
Malin Levin is an Associate Professor with an overall research interest in lipid accumulation and storage in the heart. In specifics, her group is interested in elucidating the function of lipid droplet-associated proteins in the heart and their relevance for intracellular lipid accumulation, mitochondrial function and impact on outcome of myocardial ischemia. Main research Pathological conditions, e.g. obesity, diabetes and myocardial ischemia, are associated with increased lipid accumulation in the heart. Elevated levels of myocardial lipids are associated with cellular and tissue dysfunction, and are believed to contribute to reduced heart function. Intracellular lipids are stored in lipid droplets, with a core of neutral lipids and a complex surface containing membrane lipids and associated proteins. Lipid droplet-associated proteins contribute to the regulation of lipid droplet size and stability and mediate coupling between lipid droplets and mitochondria. Stable lipid droplet storage and
Fat-specific protein (FSP)27/Cidec is most highly expressed in white and brown adipose tissues and increases in abundance by over 50-fold during adipogenesis. However, its function in adipocytes has remained elusive since its discovery over 15 years ago. Here we demonstrate that FSP27/Cidec localizes to lipid droplets in cultured adipocytes and functions to promote lipid accumulation. Ectopically expressed FSP27-GFP surrounds lipid droplets in 3T3-L1 adipocytes and colocalizes with the known lipid droplet protein perilipin. Immunostaining of endogenous FSP27 in 3T3-L1 adipocytes also confirmed its presence on lipid droplets. FSP27-GFP expression also markedly increases lipid droplet size and enhances accumulation of total neutral lipids in 3T3-L1 preadipocytes as well as other cell types such as COS cells. Conversely, RNA interference-based FSP27/Cidec depletion in mature adipocytes significantly stimulates lipolysis and reduces the size of lipid droplets. These data reveal FSP27/Cidec as a ...
НИИ атеросклероза: научные исследования, публикации сотрудников института (abstracts, full-text.), дискуссионный клуб, посвященный вопросам механизмов атерогенеза.
The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism. However, the transcriptional regulation of this pathway in response to metabolic cues is uncharacterized. Here we show that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is induced by starvation through an autoregulatory feedback loop and exerts a global transcriptional control on lipid catabolism via Ppargc1α and Ppar1α. Thus, during starvation a transcriptional mechanism links the autophagic pathway to cellular energy metabolism. The conservation of this mechanism in Caenorhabditis elegans suggests a fundamental role for TFEB in the evolution of the adaptive response to food deprivation. Viral delivery of TFEB to the liver prevented weight gain and metabolic syndrome in both diet-induced and genetic mouse models of obesity, suggesting a new therapeutic strategy for disorders of lipid metabolism. Ballabio and
β-Casomorphin increases fat deposition in broiler chickens by modulating expression of lipid metabolism genes - Volume 13 Issue 4 - W. H. Chang, A. J. Zheng, Z. M. Chen, S. Zhang, H. Y. Cai, G. H. Liu
Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and induces lipotoxic events, ultimately contributing to the development of insulin resistance. Lipid droplet (LD)-coating proteins may control proper lipid storage in skeletal muscle. Perilipin 2 (PLIN2/adipose differentiation-related protein [ADRP]) is one of the most abundantly expressed LD-coating proteins in skeletal muscle. Here we examined the role of PLIN2 in myocellular lipid handling and insulin sensitivity by investigating the effects of in vitro PLIN2 knockdown and in vitro and in vivo overexpression. PLIN2 knockdown decreased LD formation and triacylglycerol (TAG) storage, marginally increased fatty-acid (FA) oxidation, and increased incorporation of palmitate into diacylglycerols and phospholipids. PLIN2 overexpression in vitro increased intramyocellular TAG storage paralleled with improved insulin sensitivity. In vivo ...
Lipid droplets in the liver are coated with the perilipin family of proteins notably adipocyte differentiation-related protein (ADRP) and tail-interacting protein of 47 kDa (TIP47). TIP47 mRNA and protein levels were increased in response to a high-fat diet (HFD) in C57BL/6J mice. TIP47 ASO treatment decreased liver TIP47 mRNA and protein levels without altering ADRP levels. Low-dose TIP47 ASO (15 mg/kg) and high-dose TIP47 ASO (50 mg/kg) decreased triglyceride content in the liver by 35% and 52% respectively. Liver histology showed a drastic reduction in hepatic steatosis following TIP47 ASO treatment. Rabbit Polyclonal to UBTD2. The high dose of TIP47 ASO significantly blunted hepatic triglyceride secretion improved glucose tolerance and improved insulin level of sensitivity in liver adipose cells and muscle mass. These findings display that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders. gene ...
Lipid metabolism is the synthesis and degradation of lipids in cells. Lipid metabolism is the break down or storage of fats for energy; these fats are obtained from consuming food and absorbing them or they are synthesized by an animals liver. Lipogenesis is the process of synthesizing these fats. The majority of lipids found in the human body from ingesting food are Triglycerides. Since lipids are fats, lipid metabolism is often considered the digestion and absorption process of dietary fats. Lipid metabolism often begins with hydrolysis, which occurs when a chemical breaks down as a reaction to coming in contact with water. Lipid metabolism does exist in plants, though the processes differ in some ways when compared to animals. Digestion is the first step to lipid metabolism, and is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes. Digestion of fats begin in the mouth through chemical digestion by lingual lipase. Lipids then ...
The present review aims to systematically and critically analyze the current knowledge on phospholipases and their role in physiological and pathological mineralization undertaken by mineralization competent cells. Cellular lipid metabolism plays an important role in biological mineralization. The physiological mechanisms of mineralization are likely to take place in tissues other than in bones and teeth under specific pathological conditions. For instance, vascular calcification in arteries of patients with renal failure, diabetes mellitus or atherosclerosis recapitulates the mechanisms of bone formation. Osteoporosis-a bone resorbing disease-and rheumatoid arthritis originating from the inflammation in the synovium are also affected by cellular lipid metabolism. The focus is on the lipid metabolism due to the effects of dietary lipids on bone health. These and other phenomena indicate that phospholipases may participate in bone remodelling as evidenced by their expression in smooth muscle cells, in
TY - JOUR. T1 - PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. AU - Medina-Gomez, G.. AU - Gray, S.L.. AU - Yetukuri, Laxman. AU - Shimomura, K.. AU - Campbell, M.. AU - Curtis, K.. AU - Virtue, S.. AU - Jimenez-Linan, M.. AU - Blount, M.. AU - Yeo, G.S.H.. AU - Lopez, M.. AU - Seppänen-Laakso, Tuulikki. AU - Ashcroft, F.M.. AU - Oresic, Matej. AU - Vidal-Puig, A.. PY - 2007. Y1 - 2007. N2 - Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2−/− Lepob/Lepob (POKO mouse), resulted in decreased fat mass, severe insulin resistance, β-cell failure, and dyslipidaemia. Our results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance. Lipidomic analyses suggest that PPARg2 plays an important antilipotoxic role when induced ectopically in liver and ...
Tumor protein D52 (TPD52) is amplified/ over-expressed in cancers of diverse cellular origins. Altered cellular metabolism (including lipogenesis) is a hallmark of cancer development, and protein-protein associations between TPD52 and known regulators of lipid storage, and differential TPD52 expression in obese versus non-obese adipose tissue, suggest that TPD52 may regulate cellular lipid metabolism. We found increased lipid droplet numbers in stably TPD52-expressing BALB/c 3T3 cell lines, compared with control and TPD52L1-expressing cell lines. TPD52-expressing 3T3 cells showed increased fatty acid storage in triglyceride (from both de novo synthesis and uptake), and formed greater numbers of lipid droplets upon oleic acid supplementation than control cells. TPD52 co-localised with Golgi but not ER markers, and also showed partial co-localisation with Adrp-coated lipid droplets, with a proportion of TPD52 being detected in the lipid droplet fraction. Direct interactions between ADRP and TPD52, ...
Physiological processes are differentially regulated between men and women. Sex and gut microbiota have each been demonstrated to regulate host metabolism, but it is unclear whether both factors are interdependent. Here, we determined to what extent sex-specific differences in lipid metabolism are m …
Fingerprint Dive into the research topics of Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance. Together they form a unique fingerprint. ...
Several nutrition and food ingredients are supposed to have beneficial effects, but precise cell biological mechanism has not been elucidated. Among food ingredients, polyphenols such as soy bean isoflavon genistein and wine resveratrol have been reported to have effects on lipid metabolism and cardiovacular diseases (1). In order to elucidate the effect of genistein on obesity, we cultured adipocyte and observed of genisten to lipid accumulation in cells. Triglyceride accumulation was suppressed by genistein when it was added at the time of differentiation but not when added after differentiation. Genistein is considered to suppress lipid accumulation by suppressing the differtiation of adipocytes.
Atherosclerosis is driven by lipid accumulation in the arterial wall that leads to narrowing the vessel lumen and increasing risk of thrombus formation. Deposition of lipids, mostly cholesteryl esters, in the arterial wall layer called intima, is one of the earliest manifestations of the disease. Intracellular accumulation of lipids takes place in so called foam cells that have their cytoplasm filled with lipid droplets that are visible microscopically. Circulating low-density lipoprotein (LDL) particles serve as the primary source of lipids. Numerous attempts were made to establish a clear link between circulating LDL levels and atherosclerosis formation. In the experiments conducted on cultured cells, if was demonstrated that native LDL failed to induce intracellular lipid accumulation. At the same time, LDL chemically modified in vitro (acetylated, malondialdehyde-treated, oxidized with ions of transient metals, etc.) induced lipid deposition in cultured cells, i.e., was atherogenic. It was ...
Adipose differentiation-related protein, also known as perilipin 2 , ADRP or adipophilin, is a protein which belongs from PAT family of cytoplasmic lipid droplet(CLD) binding protein. In humans it is encoded by the ADFP gene. This protein surrounds the lipid droplet along with phospholipids and are involved in assisting the storage of neutral lipids within the lipid droplets. The adipose differentiation related protein (ADRP) was first characterized as an mRNA molecule that express early in adipocyte differentiation. The full length cDNA was cloned by rapid amplification of cDNA ends method and sequence analysis results in a protein with 425 amino acids that is unique and similar sequences had not previously been reported. In human, the gene for adipose differentiation related protein is located at short p arm of chromosome 9 at region 22 band 1 from base pair 19108391 to 19127606 (GRCh38.p7) (map). The proposed models for adipose differentiation related protein (perilipin 2) is maintained by ...
Annexin A6 (AnxA6) has been implicated in the regulation of endo-/exocytic pathways, cholesterol transport, and the formation of multifactorial signaling complexes in many different cell types. More recently, AnxA6 has also been linked to triglyceride storage in adipocytes. Here we investigated the potential role of AnxA6 in fatty acid (FA) induced lipid droplet (LD) formation in hepatocytes. AnxA6 was associated with LD from rat liver and HuH7 hepatocytes. In oleic acid (OA) -loaded HuH7 cells, substantial amounts of AnxA6 bound to LD in a Ca2+-independent manner. Remarkably, stable or transient AnxA6 overexpression in HuH7 cells led to elevated LD numbers/size and neutral lipid staining under control conditions as well as after OA loading compared to controls. In contrast, overexpression of AnxAl, AnxA2 and AnxA8 did not impact on OA-induced lipid accumulation. On the other hand, incubation of AnxA6-depleted HuH7 cells or primary hepatocytes from AnxA6 KO-mice with OA led to reduced FA ...
Movement of circulating fatty acids (FAs) to parenchymal cells requires their transfer across the endothelial cell (EC) barrier. The multiligand receptor cluster of differentiation 36 (CD36) facilitates tissue FA uptake and is expressed in ECs and parenchymal cells such as myocytes and adipocytes. Whether tissue uptake of FAs is dependent on EC or parenchymal cell CD36, or both, is unknown. Using a cell-specific deletion approach, we show that EC, but not parenchymal cell, CD36 deletion increased fasting plasma FAs and postprandial triglycerides. EC-Cd36-KO mice had reduced uptake of radiolabeled long-chain FAs into heart, skeletal muscle, and brown adipose tissue; these uptake studies were replicated using [11C]palmitate PET scans. High-fat diet-fed EC-CD36-deficient mice had improved glucose tolerance and insulin sensitivity. Both EC and cardiomyocyte (CM) deletion of CD36 reduced heart lipid droplet accumulation after fasting, but CM deletion did not affect heart glucose or FA uptake. ...
Movement of circulating fatty acids (FAs) to parenchymal cells requires their transfer across the endothelial cell (EC) barrier. The multiligand receptor cluster of differentiation 36 (CD36) facilitates tissue FA uptake and is expressed in ECs and parenchymal cells such as myocytes and adipocytes. Whether tissue uptake of FAs is dependent on EC or parenchymal cell CD36, or both, is unknown. Using a cell-specific deletion approach, we show that EC, but not parenchymal cell, CD36 deletion increased fasting plasma FAs and postprandial triglycerides. EC-Cd36-KO mice had reduced uptake of radiolabeled long-chain FAs into heart, skeletal muscle, and brown adipose tissue; these uptake studies were replicated using [11C]palmitate PET scans. High-fat diet-fed EC-CD36-deficient mice had improved glucose tolerance and insulin sensitivity. Both EC and cardiomyocyte (CM) deletion of CD36 reduced heart lipid droplet accumulation after fasting, but CM deletion did not affect heart glucose or FA uptake. ...
Movement of circulating fatty acids (FAs) to parenchymal cells requires their transfer across the endothelial cell (EC) barrier. The multiligand receptor cluster of differentiation 36 (CD36) facilitates tissue FA uptake and is expressed in ECs and parenchymal cells such as myocytes and adipocytes. Whether tissue uptake of FAs is dependent on EC or parenchymal cell CD36, or both, is unknown. Using a cell-specific deletion approach, we show that EC, but not parenchymal cell, CD36 deletion increased fasting plasma FAs and postprandial triglycerides. EC-Cd36-KO mice had reduced uptake of radiolabeled long-chain FAs into heart, skeletal muscle, and brown adipose tissue; these uptake studies were replicated using [11C]palmitate PET scans. High-fat diet-fed EC-CD36-deficient mice had improved glucose tolerance and insulin sensitivity. Both EC and cardiomyocyte (CM) deletion of CD36 reduced heart lipid droplet accumulation after fasting, but CM deletion did not affect heart glucose or FA uptake. ...
For humans it is crucial to control lipid homeostasis to avoid development of metabolic disorders. Dyslipidemia is a considerable risk factor for development of cardiovascular and liver diseases, such as non-alcoholic fatty liver disease (NAFLD). Infection and inflammation induce the acute phase response (APR), leading to multiple alternations in lipid and lipoprotein metabolism, mediated by changed cytokine production, especially tumor necrosis factor (TNF)-a, interleukin (IL)-1 and IL-6. Another cytokine IL-10 has anti-atheromatous and anti-inflammatory effects, and it has been postulated that IL-10 has gene therapeutic potential. However, the effect of IL-10 on liver and its metabolic functions are still unclear. In the present study, we investigated whether IL-10 could modulate lipid homeostasis in TNF-a- and IL-6-stimulated hepatocytes. We demonstrated that IL-6 increased expression of genes involved in hepatic fatty acid (FA) synthesis [SREBP1a, FAS], FA oxidation [PPARa, CPT1a, CPT2], FA ...
BioAssay record AID 1656 submitted by Burnham Center for Chemical Genomics: High Throughput Imaging Assay for Hepatic Lipid Droplet Formation.
Since July 2001, JLR has published special Thematic Review Series - a series of articles on a hot lipid-related topic appearing in consecutive issues. Thematic Reviews are among the most widely read of all JLR articles.. For each of these series, an Associate Editor (sometimes in conjunction with a member of the JLR Editorial Board) will invite experts in that field to contribute reviews on a specific topic or theme. Many topics have been explored in JLR Thematic Review Series; sterol/lipid metabolism and transport, systems biology approaches to metabolic and cardiovascular disorders, membranes and polar lipid dynamics, and sphingolipids are just a few examples.. Patient-Oriented and Epidemiological Research articles ...
Abnormal lipid metabolism associated with various renal diseases has been known for a long time. Hypercholesterolemia is one of the characteristic features of nephotic syndrome, and hypertriglyceridemia is often observed in chronic renal failure (CRF). The role of lipid abnormalities in the pathogenesis of renal diseases has been variously discussed. However, direct evidence only recently became possible when more sophisticated analyses of renal histopathology as well as an application of molecular biology were introduced in the field of clinical nephrology. The recent identification of lipoprotein nephropathy (LPG), reported most often by Japanese authors since 1989, is particularly noteworthy. The detailed analysis of lipid profiles and renal histology has been instrumental in clarifying the relationship between lipids and the kidney not only in LPG but also in other disease entities such as familial-type dyslipidemias, CRF, focal glomerulosclerosis, and diabetic nephropathy. Dyslipidemias ...
Lipid droplets are lipid stores inside cells that are surrounded by a phospholipid bilayer and are often found insidide adipocytes. Lipid droplets are able to store neutral lipids e.g. triaclycerides and cholesterol esters that are synthesised in the endoplasmic reticulum. The lipids stored inside the droplets are neutral due to the fact they contain no hydrophilic head groups, instead all containing hydrophobic constituent molecules, that clump into droplets rather than bilayer (as would happen if they contained hydrophilic heads) [1]. ...
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Tumor necrosis factor α (TNFα) is an inflammatory cytokine that plays a central role in obesity-induced insulin resistance. It also controls cellular lipid metabolism but the underlining mechanism is poorly understood. We report here that phosphoinositide 3-kinase enhancer A (PIKE-A) is a novel effector of TNFα to facilitate its metabolic modulation in the skeletal muscle. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNFα on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses. We also found that TNFα promoted the interaction between PIKE-A and AMP-activated protein kinase (AMPK) to suppress its kinase activity in vitro and in vivo. As a result, animals with PIKE ablation in the skeletal muscle per se display an upregulation of AMPK phosphorylation and a higher preference to utilize lipid as the energy production substrate under high-fat diet feeding, which mitigates the development of diet-induced ...
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It is well known that metabolic responses to diet and drugs are affected by genetic and environmental factors. Still, a large part of differences in responses between individuals remains unexplained. To increase our understanding of individual differences, more and more attention is paid to the role of intestinal microbiota. Not only energy and glucose may be related to the microbiota, but also lipid metabolism. This is not surprising as lipid metabolism, glucose metabolism, and obesity are closely linked.. There is substantial evidence from in particular animal studies that the gut microbiota is related to lipid and lipoprotein metabolism. However, there is less evidence to what extent modulation of the gut microbiota changes lipid and lipoprotein metabolism in humans. ...
Increasing evidence suggests that the various components of açaí contribute to cardioprotection via mechanisms that affect cell membrane receptors, intracellular signaling pathway proteins, and the modulation of gene expression [37],. [38], [39], [40] and [41]. It has been demonstrated that flavonoids regulate the activity of the Alisertib nuclear receptor regulators of cellular lipid metabolism [42] and [43]. The present study was designed to investigate the hypocholesterolemic activity of açaí pulp using a rat model of dietary-induced hypercholesterolemia. A 2% açaí pulp dose was chosen because of its relevance to human nutrition. This dosage mimics the addition of a portion of this fruit in food [44] and selleck compound has demonstrated effects in previous studies [10], [15] and [16]. Corroborating our previous results [15], açaí supplementation improved the lipid profile in the rat. Thus, we focused on characterizing the effects that açaí pulp supplementation in the diet would ...
Proper regulation of lipid metabolism is central to human health. Disruption of lipid metabolic pathways can lead to a variety of diseases including diabetes an...
During fasting, increased concentrations of circulating catecholamines promote the mobilization of lipid stores from adipose tissue in part by phosphorylating and inactivating acetyl-coenzyme A carboxylase (ACC), the rate-limiting enzyme in fatty acid synthesis. Here, we describe a parallel pathway, in which the pseudokinase Tribbles 3 (TRB3), whose abundance is increased during fasting, stimulates lipolysis by triggering the degradation of ACC in adipose tissue. TRB3 promoted ACC ubiquitination through an association with the E3 ubiquitin ligase constitutive photomorphogenic protein 1 (COP1). Indeed, adipocytes deficient in TRB3 accumulated larger amounts of ACC protein than did wild-type cells. Because transgenic mice expressing TRB3 in adipose tissue are protected from diet-induced obesity due to enhanced fatty acid oxidation, these results demonstrate how phosphorylation and ubiquitination pathways converge on a key regulator of lipid metabolism to maintain energy homeostasis ...
Introduction. Biochemistry Assignment 7 Task 5) - Explore and explain the main features involved in the anabolic metabolism of carbohydrate (glycogenisis), lipid metabolism (triglyceride storage, transport and ketosis) and protein metabolism (transamination and deamination). Anabolic metabolism is the building of larger molecules from smaller ones, for example building monosaccharides to form carbohydrates; fatty acids and glycerol to form lipids and amino acids to form proteins. They are generally condensation reactions, producing water as two molecules join together to make a larger molecule. All living cells must metabolise to produce vital energy that is required for active processes, this requires glucose. The normal glucose level is 90mg of glucose in 100cm3 of blood it is essential that this level remains and the body controls this in two ways, the breakdown of products to form glucose and synthesis of larger molecules from glucose in order that it be stored. Glycogenisis is the ...
PubMed journal article: Effects of alternations (10 days) of high-fat with normal diet on liver lipid infiltration, fat gain, and plasma metabolic profile in rats. Download Prime PubMed App to iPhone, iPad, or Android
Adipocytes store triglyceride during periods of nutritional affluence and release free fatty acids during fasting through coordinated cycles of lipogenesis and lipolysis. While much is known about the acute regulation of these processes during fasting and feeding, less is understood about the transc …
K. G. Taylor, D. J. Galton, G. Holdsworth; Insulin-Independent Diabetes: Defects in the Regulation of Two Adipocyte Enzymes Involved in Carbohydrate and Lipid Metabolism. Clin Sci Mol Med 1 September 1978; 55 (3): 2P-3P. doi: https://doi.org/10.1042/cs055002Pb. Download citation file:. ...
Read Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes, Toxicological Sciences on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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Tripathi, S.N. (1973) Clinical and experimental studies on the use of oleoresin guggula, an indigenous drug in the disorders of lipid metabolism (with special reference to atherosclerosis and obesity). [Publication] Full text not available from this repository ...
isorder: Disorders of lipid metabolism is caused due to profound enzyme deficiency, resulting in severe early onset multi systemic disease. Typically,..
Author: Field, Cameron et al.; Genre: Journal Article; Published in Print: 2020-02-04; Open Access; Title: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Supports glucose metabolism and lipid utilization‡ Promotes weight management‡ Made with hypoallergenic, vegetarian ingredients PureLean® Nutrients promotes healthy weight management by supporting healthy glucose metabolism and lipid utilization. PureLean® Nutrients also supports healthy lipid antioxidant protection an
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SkinCeuticals TRIPLE LIPID RESTORE 2:4:2 Aging skin is increasingly susceptible to lipid depletion; the loss of natural compounds in skin s surface,
Dr. Chung is focusing on the biology of fat storage organelles called lipid droplets (LDs). Many cancer cells are characterized by an increased number of LDs, and this accumulation has been proposed to be pathogenic. Key questions of LD biology remain unanswered, limiting the potential for therapeutic intervention. She will combine various imaging technologies and biochemical approaches to elucidate the molecular architecture of initial LD formation and its regulation.. ...