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Determination of sulfonamides by liquid chromatography, ultraviolet diode array detection and ion-spray tandem mass spectrometry with application to cultured salmon flesh
Determination of sulfonamides by liquid chromatography, ultraviolet diode array detection and ion-spray tandem mass spectrometry with application to cultured salmon flesh
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TY - JOUR. T1 - Quantification of sunitinib in human plasma by high-performance liquid chromatography-tandem mass spectrometry. AU - Minkin, Patton. AU - Zhao, Ming. AU - Chen, Zhaoyuan. AU - Ouwerkerk, Jan. AU - Gelderblom, Hans. AU - Baker, Sharyn D.. PY - 2008/10/15. Y1 - 2008/10/15. N2 - A rapid, sensitive and specific method was developed and validated using LC/MS/MS for determination of sunitinib in human plasma. Sample preparation involved a liquid-liquid extraction by the addition of 0.2 mL of plasma with 4.0 mL tert-butyl-methyl-ether extraction solution containing 25 ng/mL of the internal standard clozapine. Separation of compounds was achieved on a C18 (50 mm × 2.1 mm i.d., 3.5 μm) analytical column using a mobile phase consisting of acetonitrile/H20 (65:35, v/v) containing 0.1% formic acid and isocratic flow at 0.150 mL/min for 3 min. The analytes were monitored by tandem-mass spectrometry with electrospray positive ionization. Linear calibration curves in human plasma were ...
It introduces a square wave voltammetric (SQV) technique for the determination of Nepafenac in pharmaceutical dosage form and human serum with accepte..
Development and validation of an LC-MS/MS method for the determination of pelubiprofen and its active metabolite, trans-alcohol, in human plasma and its applica
drugs (Table I). Regression analysis was made for The overlain spectrum (Fig. 3) of pioglitazone the slope (m), intercept (c) and correlation coefficient and glimepiride was found to be appropriate for the (R) as shown in Table I. Higher values of correlation estimation of both the drugs. based on the point of coefficient (R) indicate good linearity of the calibration maximum absorbance the λ of pioglitazone and curve for both the drugs as shown in Fig. 4. glimepiride was found to be 279 and 238 nm. The response for Pioglitazone was found to be linear in the concentration range of 2 - 30 µg/mL at 279 determined by inter- and intra-day precision methods. nm with correlation coefficient of 0.9904 (Table 1). The results varied between 98.34 and 98.4 % in Similarly, the derivative response for the glimepiride case of inter-day precision for simultaneous equation was found to be linear in the concentration range of method while in case of intra-day precision it ranged 1 - 20 µg/mL at 238 nm with ...
CORTECS C8 VanGuard Pre-Columns are used to extend analytical column lifetime and performance by removing particulate contamination from the mobile phase stream. This Pre-Column is optimized to protect all CORTECS UPLC C8 analytical columns containing 1.6 µm sorbent particles.
Calibration curve of the sensor showing the two possible regions of measurement: region I (front-slope) in blue and region II (back-slope) in red.
Calibration curves for the indirect heterogeneous sandwich ELISA of free-CN54gp140 (□ CN54gp140-spiked 3% RSV, ■ CN54gp140 in PBST, n = 4).
For integrated automated purification and assay setup, with manual transfer to the detection unit for all molecular testing needs
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Im happy with those numbers and am curious what you all think of them. Honestly I dont think its possible to get less than that for either Nano or Necroa, which tells you how long I worked them. Let me know ...
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In analytical chemistry, the detection limit, lower limit of detection, or LOD (limit of detection), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal. There are a number of different "detection limits" that are commonly used. These include the instrument detection limit (IDL), the method detection limit (MDL), the practical quantification limit (PQL), and the limit of quantification (LOQ). Even when the same terminology is used, there can be differences in the LOD according to nuances of what definition is used and what type of noise contributes to the measurement and calibration. The figure below illustrates the ...
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A rapid and selective high-throughput HESI-LC-MS/MS method for determining eight cytochrome P450 probe drugs in one-step extraction and single run was developed and validated. The four specific probe
Data on Production of Selected Bulk Drugs of Selected Companies in the Organised Sector During 1998-99, 1999-2000, 2000-2001, 2001-2002 and 2002-2003 ...
The National Horsemens Benevolent and Protective Association medication committee hopes to establish what it calls proper regulatory thresholds for trace levels of the urinary metabolites of cocaine and morphine.
Find elemental trace level articles on Environmental XPRT, the worlds largest environmental industry marketplace and information resource.
A nanoreactor approach based on the amphiphilic assembly of various molecules offers a chance to finely engineer the internal reaction medium to enable highly selective and sensitive detection of H2S in biological media, being useful for microscopic imaging of cellular processes and in vitro diagnostics with
To compare the sensitivity, reproducibility, and to practice more, it is necessary to go through the whole procedure by real samples again ...
The PerkinElmer Elite BAC 2 Advantage, 0.18 mm i.d. column completes run times in less than 2 minutes, increasing your throughput.
The PerkinElmer Elite BAC 2 Advantage, 0.18 mm i.d. column completes run times in less than 2 minutes, increasing your throughput.
XRD和XRF用于元素和相位分析 在研究行星进程和地球结构时,地质学家定期分析岩石和矿物样品的成分和分子结构。在地质研究中一直作为重要工具的X射线分析技术在微区励磁、Mapping分析和无标准定量分析方面变得更加高功率化。X射线荧光(XRF)是表征地质材料的元素组成的关键技术。最新一代的波长色散XRF仪器采用微区分析和XY轴样品台来自动进行一个样品的多个测量,从而制作一个化学组成图。测量相组成时采用X射线衍射(XRD)。X射线衍射数据的Rietveld分析是当下公认的最具效率的晶相定量分析法。理学的专业知识和技术为这些测量提供了一些独有的解决方法。 2034502544
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I am designing a solution for load balancing. I have two routers to two separate ISPs. I have set up 2 static routes in EIGRP to 0.0.0.0 0.0.0.0 to the next hope addresses which are the routers...
教学仪器方法:XRF、XRD、化学晶体学和拉曼除了向高级或困难的应用程序提供传统的最新的解决方法,理学公司还特别提供基于创新技术,加上创意包装和有助于教学的设计的产品。学术界的面临的两大问题分别是没有足够的实验室空间和使用困难的分析软件。此外,大学高校需要价格合理且大小适当的
In recent years, high levels of hormone residue in food, capable of damaging the health of consumers, have been recorded frequently. In this study, 195 raw milk samples were obtained from Tangshan City, China, and the concentrations of 22 steroid hormones were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Cortisol was detected in 12.5% of raw milk samples (mean 0.61 µg/kg; range: <limit of quantification (LOQ)-0.94 µg/kg). Progesterone was detected in 85.9% of raw milk samples (mean 5.12 µg/kg; range: <LOQ-9.04 µg/kg). The concentration of cortisol present in milk was lower than the maximum residue limit defined in Japan (10 µg/kg). Children aged between one and five years were expected to be the at-risk population when exposed to detectable steroid hormone concentrations. Based on the mean and maximum concentrations of progesterone detected in milk, the contribution was 0.85% and 0.9%, and 1.48% and 1.6% of the acceptable daily intake for boys and
TY - BOOK. T1 - Stability-indicating HPTLC determination of imatinib mesylate in bulk drug and pharmaceutical dosage. AU - Musmade, P.. AU - Vadera, N.. AU - Subramanian, G.. N1 - cited By 0. PY - 2011. Y1 - 2011. U2 - 10.1007/978-3-642-14025-9_6. DO - 10.1007/978-3-642-14025-9_6. M3 - Book. BT - Stability-indicating HPTLC determination of imatinib mesylate in bulk drug and pharmaceutical dosage. ER - ...
An accurate and sensitive reversed-phase high-performance liquid chromatograph-ic method for determination of sertraline in human serum is described using 4-chloro-7-nitrobenzofurazan as pre-column derivatization agent. The drug and an internal standard (azithrimycin) were extracted from serum using a mixture of diethyl ether-chloroform and subjected to the pre-column derivatization with the reagent. Analysis of the resulted derivatives was performed on a Lichrosorb CN (250×4.0 mm) column using a mobile phase composed of methanol and sodium phosphate buffer (0.05 M; pH 3.7) containing 2 ml/lit triethylamine (63:37 v/v). Detector response was monitored at excitation and emission wavelengths of 470 and 537 nm, respectively. The calibration curve was linear over the concentration range of 2 to 640 ng/ml. The lower limits of detection and quantification were 0.5 and 2 ng/ml, respectively. The validation of the analysis was carried out in terms of specificity, sensitivity, linearity, precision,
Sigma-Aldrich offers abstracts and full-text articles by [Hironobu Umezawa, Xiao-Pen Lee, Yoshiko Arima, Chika Hasegawa, Hikaru Izawa, Takeshi Kumazawa, Keizo Sato].
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Results: The retention time was observed at 2.718 min. The system suitability results were found to be within limits. The method was precise, with lower than 2 %RSD and the calibration curve was linear (r2=1) over a concentration range of 2.5-160 µg/ml. The detection and quantification limit was found to be 0.045 µg/ml and 0.15 µg/ml, respectively. Recovery of the drug was found between 100.09-100.19%. The assay of ropinirole hydrochloride in ROPITOR® and ROPARK® tablets were found to be 100.4 and 103.60 %, respectively. The forced degradation studies were carried out to demonstrate the specificity of the method by exposing the API under conditions of hydrolysis, oxidation, thermal and photolytic as per ICH Q1A(R2) guidelines. ...
Transporter proteins expressed in the gastrointestinal tract play a major role in the oral absorption of some drugs, and their involvement may lead to drug-drug interaction (DDI) susceptibility when given in combination with drugs known to inhibit gut wall transporters. Anticipating such liabilities and predicting the
Crit Care Med 2009; 37: 2491.. Martens-Lobenhoffer J, Becker A, Freude H, Bode-Böger SM. Identification and quantification of the atypical metabolite ornithine-lactam in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). J Chromatogr B 2009; 877: 2284-2289.. Scalera F, Closs EI, Flick E, Martens-Lobenhoffer J, Boissel JP, Lendeckel U, Heimburg A, Bode-Böger SM ...
DEVELOPMENT AND VALIDATION OF A NEW AND STABILITY INDICATING LC METHOD FOR ANALYSIS OF PINAVERIUM BROMIDE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM ...
TABLE-US-00002 TABLE 2 After 5 min. (total) run time Ratio of After 1 min. (total) run time after addition of food soil Product Surfactant Initial 15 Sec. 1 Min. Initial 15 Sec. 1 Min. Genapol/LF-221/Neodol 45-13/25R2 equal parts 2 1 1/4 6 5 41/2 Genapol/Dehypon/LF-221/LF-500 equal parts 0 0 0 3 1/4 1/4 Genapol/LF-221/Neodol 45-13 equal parts 6 41/2 2 11 10 8 Neodol 45-13/LF-221/LF-500 equal parts 5 41/2 2 10 9 8 Neodol 45-13/LF-221/LF-500/Genapol equal parts 4 3 1/2 9 8 7 Genapol/LF-221/Novel/25R2 equal parts Trace 0 0 3 1/4 1/4 Genapol/LF-221/Novel/(2)25R2 1/1/1/2 0 0 0 21/2 ,1/8 ,1/8 Genapol/LF-221/Novel/(3)25R2 1/1/1/3 0 0 0 2 ,1/8 ,1/8 Genapol/Dehypon/LF-221/LF-500 equal parts 0 0 0 3 1/4 1/4 Genapol/Dehypon/LF-221/LF-500/25R2 equal parts 0 0 0 21/2 1/4 1/4 Genapol/Dehypon/LF-221/LF-500/(2)25R2 1/1/1/1/2 0 0 0 Genapol/LF-221/Novel equal parts Trace Trace Trace 61/2 51/2 21/2 Novel/LF-221/LF-500 equal parts Trace 0 0 41/2 2 1/2 Novel/LF-221/LF-500/25R2 equal parts 0 0 0 3 1/4 1/4 ...
Capillary zone electrophoresis-multiple/single reaction monitoring (CZE-MRM/SRM), which employed an electrokinetically driven sheath-flow electrospray interface, was used for the rapid and highly sensitive detection of protein analytes in complex tryptic digests. MRM channels were developed against a commerc 2013's Top 25 most read Analyst articles
Described here are procedures and kits for the selective detection of toxicants in environmental samples. Specifically exemplified are procedures and kits which are used to detect heavy metals. The presence of heavy metals is detected by observing the inhibition by the toxicant of a microbially produced enzyme.
Title: MIL-STD-1844, Version: -, Date: 1984-Mar-30, Desc: GAS CHROMATOGRAPHY METHOD FOR DETERMINATION OF TRACE CHLORINATED SOLVENTS HYDRAULIC FLUID (30 MAR 1984
Hi. I have a table where there is an absorbance for a 0.00 concentration (blank). I now that I have to substract that value to to each of the other absorbances that I have, but my question is... Do I have to graph (concentration 0.00, absorbance 0.00) in the calibration curve ...
CORTECS Phenyl VanGuard Cartridges are used to extend analytical column lifetime and performance by removing particulate contamination from the mobile phase stream. This cartridge is optimized to protect all 4.6 mm I.D. CORTECS Phenyl analytical columns containing 2.7 µm sorbent particles.
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Ceftriaxone pharmacokinetics by a sensitive and simple LC-MS/MS method: Development and application. J Pharm Biomed Anal. 2020 Jul 21;189:113484 Authors: Herrera-Hidalgo L, Gil-Navarro MV, Dilly ...
در این پژوهش، کانی‌های رس سپیولیت و بنتونیت با بیوپلیمر کیتوزان اصلاح شد و ویژگی‌های جذبی آنها برای جذب سرب، در حالت بسته تحت شرایط مختلف، مانند زمان تماس و غلظت اولیه سرب مورد بررسی قرار گرفت. جاذب‌ها با استفاده از روش‌های XRD، XRF، FTIR، SEM و TOC مشخصه‌یابی شد و همدماها و سینتیک جذب سرب توسط این جاذب‌ها بررسی شد. مدل‌های همدمای لانگمیر و فروندلیچ برای توصیف داده‌های تعادلی به‌کار برده شد و ثابت‌های همدماها نیز تعیین شد. مدل فروندلیچ به‌خوبی داده‌های آزمایش جذب سرب به‌وسیله جاذب‌ها را توصیف نمود. پس از اصلاح رس‌ها با کیتوزان، ظرفیت جذب سرب به‌وسیله
article{531275, abstract = {Liquid chromatographic methods were used for the detection of ochratoxin A (OTA) and its metabolites ochratoxin alpha (OT alpha), 10-hydroxy OTA (10-OHOTA), 4R-hydroxy OTA (4R-OHOTA) and the ethyl ester of OTA (OTC) in in vitro samples, obtained with Caco-2 cell culture experiments and in in vivo urine samples from sheep. A high-performance liquid chromatography method with fluorescence detection (HPLC-FLD) and a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method were developed and validated for the detection of OTA and its metabolites OTo 10-OHOTA, 4R-OHOTA and OTC, which was used as internal standard. The LOD/LOQ values for OT alpha, 4R-OHOTA and OTA were 0.63/2.11, 0.99/3.31 and 0.84/2.81 mu g/L, respectively, for the HPLC-FLD method and 0.98/3.28, 1.11/3.72 and 0.88/2.96 mu g/L, respectively for the LC-MS/MS method. Within-day and between-day precision were both ,12% for the HPLC-FLD method, and ,10% for the LC-MS/MS method. The recovery of OTA and ...
نسخه قابل چاپ خلاصه مقاله QSRR models of veterinary drugs in milk in ultra-performance liquid chromatography coupled to time of flight mass spectrometry - گواهی پذیرش مقاله در کنفرانس
Steuer, Andrea E; Poetzsch, Michael; Stock, Lorena; Eisenbeiss, Lisa; Schmid, Yasmin; Liechti, Matthias E; Kraemer, Thomas (2017). Development and validation of an ultra-fast and sensitive microflow liquid chromatography-tandem mass spectrometry (MFLC-MS/MS) method for quantification of LSD and its metabolites in plasma and application to a controlled LSD administration study in huma. Drug Testing and Analysis, 9(5):788-797. ...