Phytoestrogens have been linked to a risk of breast cancer. The main phytoestrogens in the Finnish diet are lignans, and enterolactone is quantitatively the most important circulating lignan. The purpose of this study was to examine the association between serum enterolactone and risk of breast cancer in Finnish women. The subjects were participants of the Kuopio Breast Cancer Study. This analysis concerns 194 breast cancer cases (68 premenopausal and 126 postmenopausal) who entered the study before diagnosis and 208 community-based controls. They completed a validated food frequency questionnaire referring to the previous 12 months and gave serum samples before the examinations. The measurement of serum enterolactone was performed by time-resolved fluoroimmunoassay. The statistical analyses were done by the logistic regression method. The mean serum enterolactone concentration was 20 nmol/l for the cases and 26 nmol/l for the controls (P 0.003). The mean serum enterolactone concentration in the ...
Dietary lignan intakes have been associated with reduced breast cancer risks; however, no previous studies have investigated whether lignan intake might be associated with breast cancer survival. We e
Studies conducted in Asian populations have suggested that high consumption of soy-based foods that are rich in isoflavone phytoestrogens is associated with a reduced risk of breast cancer. In the prospectively examined associations between the risk of postmenopausal invasive breast cancer and dietary intakes of four plant lignans (pinoresinol, lariciresinol, secoisolariciresinol, and matairesinol) and estimated exposure to two enterolignans (enterodiol and enterolactone), as measured with a self-administered diet history questionnaire, among 58,049 postmenopausal French women who were not taking soy isoflavone supplements, posted in PubMed, showed that hgh dietary intakes of plant lignans and high exposure to enterolignans were associated with reduced risks of ER- and PR-positive postmenopausal breast cancer in a Western population that does not consume a diet rich in soy ...
The lignans are a large group of polyphenols found in plants. Some examples of lignans are enterolignans, enterodiol and enterolactone. From lign (Latin, linear) + an. Plant lignans are polyphenolic substances derived from phenylalanine via dimerization of substituted cinnamic alcohols (see cinnamic acid), known as monolignols, to a dibenzylbutane skeleton 2. This reaction is catalysed by oxidative enzymes and is often controlled by dirigent proteins. Many natural products, known as phenylpropanoids, are built up of C6C3 units (n-propylbenzene skeleton 1) derived from cinnamyl units just as terpene chemistry builds on isoprene units. Structure 3 is a neolignan, a structure formed by joining the two propylbenzene residues at other than the β-carbon atom of the propyl side chain. When a part of the human diet, some plant lignans are metabolized by intestinal bacteria to mammalian lignans enterodiol (1) and enterolactone (2). Lignans that can be metabolized to mammalian lignans are pinoresinol, ...
Lignans are an anticancer plant compound found in red wine, whole grains, cruciferous vegetables, sesame seeds and flaxseeds. Flaxseeds may contain up to 800 times more lignans than any other foods. Flaxseeds also give you the most bang for your buck at just $1 per pound in the bulk food section. Just a teaspoon a day can give you your daily dose (although make sure it is ground flaxseed or else the nutrients may not be absorbed). Those who eat a plant-based diet will most likely consume more lignans on a daily basis than those eating a diet rich in animal products.. ...
Lariciresinol is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in sesame seed, brassica vegetables, etc. Health Benefits 1. Mammary tumor growth and reduces blood vessel density In the investigation of the effects and possible mechanisms of action of lariciresinol on hormone responsive mammary cancer in vivo in dimethylbenz[a]anthracene induced mammary cancer in …. ...
The strong male predominance in esophageal and gastroesophageal junctional adenocarcinoma remains unexplained. Sex hormonal influence has been suggested, but not proven. A protective role of dietary phytoestrogen lignans was hypothesized. A Swedish nationwide population-based case-control study was conducted in 1995-1997, including 181 cases of esophageal adenocarcinoma, 255 cases of gastroesophageal junctional adenocarcinoma, 158 cases of esophageal squamous cell carcinoma, and 806 control subjects. Data on various exposures, including dietary data, were collected through personal interviews and questionnaires. Dietary intake of lignans was assessed using a food frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (ORs) with 95 % confidence intervals (CIs), including adjustment for all established risk factors. Participants in the highest quartile of intake of lignans ...
Adlercreutz, H., et al. (1982). "Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer." Lancet 2(8311): 1295-1299.. Dietary studies and assays of urinary lignans in postmenopausal women showed that lignan excretion is significantly lower in urine of women with breast cancer than in normal omnivorous and vegetarian women and confirmed that there is a significant correlation between fibre intake and lignan excretion. It is suggested that the precursors of the human lignans enterolactone and enterodiol formed by the intestinal microflora are to be found in fibre-rich foods such as grains, nuts, and legumes. Excretion of equol, which has antioestrogenic properties, was similar in all groups studied and did not correlate with fibre intake, but occasional high values were found in some subjects.. Dwyer, J. T., et al. (1982). "Nutritional status of vegetarian children." Am J Clin Nutr 35(2): ...
The use of natural products is becoming increasingly popular worldwide. Flaxseed is a source of natural products that are rich with bioactives and have been reported to modulate inflammation, blood pressure, glucose levels and lipid profiles in both humans and animals. Currently, several known bioactives including fibers, lignans, alpha-linolenic acid, and linoorbitides (LOBs) are believed to impart those pharmacological activities. Previous studies have focused on the ability of flaxseed bioactives to provide their pharmacological action in the systemic circulation. However, our increasing understanding of their pharmacokinetics and chemical structures, suggests enhanced abundance of LOBs and lignans at the level of the intestinal epithelium due to the potential lack of permeation of LOBs, and susceptibility of lignans to enterohepatic circulation. Our aim in this work is to evaluate the effects of the lignan enterolactone (ENL) and LOBs on intestinal epithelium function and how it might ...
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Brevail was university researched and developed to increase lignan concentrations in the body to match levels found in women who collectively demonstrate an extraordinary history of breast health. Brevail provides lignans that are concentrated and standardized from flaxseeds. Brevail was formulated to supplement lignans lacking in the diet, resulting in a gentle return to balance between body and nature, just as nature intended.
Lignans are phytoestrogen, a group of chemical compounds found in plants, including soybeans, cruciferous vegetables, Flax and sesame seed, rye, wheat, oat, barley and apricots and strawberries. The phytochemicals are also best know for its antioxidant properties in preventing the forming of free radical and in reacting to oxidative stress.
Background: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. Objective: We investigated the association between intake of dietary flavonoids and lignans and incident GC. Design: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. Results: During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, ...
Background: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. Objective: We investigated the association between intake of dietary flavonoids and lignans and incident GC. Design: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. Results: During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, ...
If you are a postmenopausal woman, foods rich in flavonoids and lignans reduce your risk of developing the most common type of breast cancer by about 35 per
Increased intake of lignans may reduce a postmenopausal womans risk of breast cancer by about 15 per cent, says a new meta-analysis of the available data.
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Lignans in flaxseed are known to be part of a macromolecule in which they are connected through the linker-molecule hydroxy-methyl-glutaric acid (HMGA). In this study, the lignan macromolecule was extracted from flaxseed hulls and degraded to its mon
This topic has 12 study abstracts on Enterodiol indicating that it may have therapeutic value in the treatment of Breast Cancer, Breast Cancer: Prevention, and Fibroids: Uterine
Numerous oxidative transformations of lignan structures have been reported in the literature. In this paper we present an overview on the current findings in the field. The focus is put on transformations targeting a specific structure, a specific reaction, or an interconversion of the lignan skeleton. Oxidative transformations related to biosynthesis, antioxidant measurements, and total syntheses are mostly excluded. Non-metal mediated as well as metal mediated oxidations are reported, and mechanisms based on hydrogen abstractions, epoxidations, hydroxylations, and radical reactions are discussed for the transformation and interconversion of lignan structures. Enzymatic oxidations, photooxidation, and electrochemical oxidations are also briefly reported ...
Cucumbers are now known to contain lariciresinol, pinoresinol, and secoisolariciresinol-three lignans that have a strong history of research in connection with reduced risk of cardiovascular disease as well as several cancer types, including breast, uterine, ovarian, and prostate cancers.. ...
Zamora-Ros R, Ferrari P, Gonzalez CA, Tjonneland A, Olsen A, Bredsdorff L, Overvad K, Touillaud M, Perquier F, Fagherazzi G, Lukanova A, Tikk K, Aleksandrova K, Boeing H, Trichopoulou A, Trichopoulos D, Dilis V, Masala G, Sieri S, Mattiello A, Tumino R, Ricceri F, Bueno de Mesquita HB, Peeters PHM, Weiderpass E, Skeie G, Engeset D, Menendez V, Travier N, Molina-Montes E, Amiano P, Chirlaque MD, Barricarte A, Wallstrom P, Sonestedt E, Sund M, Landberg R, Khaw KT, Wareham NJ, Travis RC, Scalbert A, Ward HA, Riboli E, Romieu ...
Flaxseed is an excellent source of two fatty acids that are essential for human health � alpha-linolenic (omega-3) and linoleic (omega-6).
Lets say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30). ...
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Takaku Naohiro , Choi Don-Ha , Mikame Keigo , OKUNISHI Tomoya , SUZUKI Shiro , OHASHI Hideo , UMEZAWA Toshiaki , SHIMADA Mikio Journal of wood science 47(6), 476-482, 2001-12-25 参考文献33件 被引用文献3件 ...
Pears are a good source of fiber, vitamins B2, C, E and minerals such as copper and magnesium. Cucumbers are a rich source of lignans, and contain triterpene...
Promotes hormonal health by promoting the bodys own production of enterolactone, which has been found to be protect against developing tumors and cardiovascular disease
Magnolol, a plant lignan isolated from the bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on chemically-induced skin cancer development. The objectives of this investigation are to study the anticarcinogenic effects of magnolol on UVB-induced skin tumor development in SKH-1 mice, a model relevant to humans, and determine the possible role of apoptosis and cell cycle arrest involved in the skin tumor development. UVB-induced skin carcinogenesis model in SKH-1 mice was used for determining the preventive effects of magnolol on skin cancer development. Western blottings and flow cytometric analysis were used to study the effects of magnolol on apoptosis and cell cycle. Magnolol pretreated groups (30, 60 μ g) before UVB treatments (30 mJ/cm2, 5 days/week) resulted in 27-55% reduction in tumor multiplicity as compared to control group in SKH-1 mice. Magnolol pretreatment increased the cleavage of caspase-8 and poly-(-ADP-ribose) polymerase (PARP), increased the
A new method based on accelerated solvent extraction (ASE) combined with response surface methodology (RSM) modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill). The RSM method, based on a three level and three variable Box-Behnken design (BBD), was employed to obtain the optimal combination of extraction condition. In brief, the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally extracted with 87% ethanol as extraction solvent, extraction temperature of 160 °C, static extraction time of 10 min, extraction pressure of 1,500 psi, flush volume of 60% and one extraction cycle. The 3D response surface plot and the contour plot derived from the mathematical models were applied to determine the optimal conditions. Under the above conditions, the experimental value of four lignans was 14.72 mg/g, which is in close agreement with the value predicted by the model.
Background: Dietary plant lignans, such as secoisolariciresinol diglucoside (SDG), are metabolized to the enterolignans, enterodiol (END) and enterolactone (ENL), by gut microbes. Evidence suggests that enterolignans may reduce risk of cardiovascular disease and several forms of cancer. Our aim was to characterize the microbial community involved in enterolignan production by using an in vitro batch culture system to enrich for lignan-metabolizing organisms. Methods: Stool samples from eight participants were incubated separately for ~1 week with a mineral salts media containing formate, acetate, glucose, and 6.55 μM SDG. Daily secoisolariciresinol (SECO), END, and ENL concentrations were measured using gas chromatography-mass spectrometry (GCMS). Microbial community in initial stool (Day 1) and in vitro-incubated fecal suspensions (final-day) was assessed via Illumina paired-end 16S rRNA gene amplicon and whole-metagenome shotgun sequencing. 16S rRNA gene sequences were taxonomically annotated ...
Also known as Magnolia total magnolols, honokiol Introduction Magnolia officianalis is the premier herb in the Traditional Chinese system of Medicine for reducing stress & anxiety while promoting the activities of the parasympathetic (rest & digest) nervous system. Extract data Origin: China Pure biphenol extract of Magnolia officinalis, standardized to a 90% total magnolol content with a 45% total being honokiol. Use Recommended amount per dose is 250-500 mg, or a half full to full size 00 capsule. Summary Magnolia is one tool that no herbalist should be without. Most effective in times of stress or anxiety, Magnolia has been shown to behave as a positive allosteric modulator of the benzodiazapine site which reduces the amount of GABA needed to activate the GABA(A) receptor. Magnolia also increases the expression of the alpha GABA receptors & has barbituate type effects. Outside of the potent GABAnergic effects, Magnolia may reduce the secretion of adrenaline from the adrenal glands, antagonize NMDA
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It is believed that honokiol acts on GABAA receptors similarly to benzodiazepines and Z-drugs. However, honokiol has been shown to achieve anxiolysis with fewer motor or cognitive side effects than GABAA receptor agonists such as flurazepam and diazepam. It has been shown that honokiol likely has a higher selectivity for different GABAA receptor subtypes and both magnolol and honokiol showed higher efficacy when acting on receptors containing δ subunits.[1] GABAA receptors control ligand-gated Cl− channels that can help increase seizure thresholds through the influx of chloride anions. Honokiol may also affect the synthesis of GABA. In a study where mice received seven daily injections of honokiol, researchers observed a significant increase in hippocampal levels of glutamate decarboxylase (GAD)(67) a precursor to GABA.[24] ...
@atanas Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00227 ‪#‎science‬ ‪#‎CVD‬ ‪#‎natural‬ ‪#‎health‬ ‪#‎medicine‬ ‪#‎cholesterol‬ #TeamGenomics #DeerwalkInc #PopulationHealthManagement #BigDatahealthCareAnalytics
Effects of lignan compounds (sesamol, sesamin, and sesamolin) extracted from roasted sesame oil on the autoxidation at 60 for 7 days and thermal oxidation at 180 for 10 hr of sunflower oil were studied by determining conjugated dienoic acid (CDA) contents, p-anisidine values (PAV), and fatty acid composition. Contents of lignan compounds during the oxidations were also monitored. a-Tocopherol was used as a reference antioxidant. Addition of lignan compounds decreased CDA contents and PAY of the oils during oxidation at 60 or heating at 180 , which indicated that sesame oil lignans lowered the autoxidation and thermal oxidation of sunflower oil. Sesamol was the most effective in decreasing CDA formation and hydroperoxide decomposition in the auto a- and thermo-oxidation of oil, and its antioxidant activity was significantly higher than that of a-tocopherol. Sesamol, sesamin, and sesamolin added to sunflower oil were degraded during the oxidations of oils, with the fastest degradation of sesamol. ...
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ABSTRACT. The health benefit through the control of lipid levels in hyperlipidaemic individuals is evident from a large number of studies. The pharmacological options to achieve this goal shall be as specific and personalized as the reasons for and co-factors of hyperlipidaemia. It was the goal of this study to reveal the impact of leoligin on cholesterol levels and to define its mechanism of action.. Oral application of leoligin in ApoE −/− mice led to significantly reduced total serum cholesterol levels and a reduction in postprandial blood glucose peak levels. In the absence of biochemical signs of toxicity, leoligin treatment resulted in reduced weight gain in mice. The effects of leoligin on serum cholesterol levels may be due to a direct inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) by a unique, non-statin-like binding mode. Postprandial serum glucose peaks may be reduced by a mild peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonistic activity of ...
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Pure Chemistry Scientific Inc. supply Good quality plant extract Magnolia Bark Extract ;Magnolol 2%-98%;Honokiol 2%-98%;Honokiol +Magnolol 2%-98%, FOB Price:1 USD/Kilogram ,Port:Shanghai ,Minimum Order Quantity:1/Kilogram ,Supply Ability:10000 Month/Kilogram,Payment Terms:L/C,T/T,Western Union,, Updatetime:Oct 25 2017, Description: Name: Honokiol IUPAC name: 2-(4-hydroxy..
Description: Approximately one hundred to two hundred species of Magnolia are found in tropical America and Asia. The genera Mangletia and Michellia are included in the genus Magnolia by some authorities. The saucer magnolia is a hybrid between two Japanese species, Magnolia heptapetala and M. liliflora. It is deciduous in winter and slow growing. Flowers may be up to six inches wide and colors range white to pink and purple. Traditionally, the magnolias were classified as dicotyledons. Some scientists believe that magnolias are descendents of a basal group of flowering plants that preceded the development of monocotyledons and dicots. ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal, close to 27 200 people died of cancer, which 1791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, alpha-linolenic acid, lignan and fibers. One of the main components of flaxseed are the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with anti-estrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acid have been shown to be able to suppress growth, size and proliferation of cancer cells
... Varieties of Magnolia available to buy include the following: MAGNOLIA acuminata ,MAGNOLIA acuminata Blue Opal ,MAGNOLIA acuminata Honey Liz ,MAGNOLIA acumin ...
... Varieties of Magnolia available to buy include the following: MAGNOLIA acuminata ,MAGNOLIA acuminata Blue Opal ,MAGNOLIA acuminata Honey Liz ,MAGNOLIA acumin ...
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Local resource for orthopedic surgeons in Magnolia. Includes detailed information on local clinics that provide access to orthopedic surgery, as well as advice and content on how the muscular and skeletal systems interact, and how orthopedic injuries occur and affect your body.
San Francisco Botanical Gardens magnolia collection includes 51 species and 33 cultivars, including many prized examples from Asia. This unique and long-standing collection began in 1939 with Eric Walther, who planted the very first magnolia in the Garden and continued to introduce species and cultivars throughout his tenure as the first Garden Director. One of the most famous species he planted was the cup and saucer magnolia or Magnolia campbellii, the first of its kind to bloom in the United States in 1940, attracting huge crowds of excited and curious visitors who stood in long lines to see the magnificent large pink blossoms of this lovely magnolia that still stands in the Garden today. More than a dozen other M. campbellii can now also be found throughout the Garden.. ...