Lichen sclerosus is also known as lichen sclerosis or lichen sclerosus et atrophicus. It is a painful skin condition that typically affects the genitals and anus.

DISCUSSION. LEA is a chronic, benign and uncommon inflammatory disease. It is more prevalent in females (ratio of 6-10 women to one man). 1,2 Higher incidence has been observed in white women aged around 40. The etiology is unknown but it is thought that genetic susceptibility plays a role in the disease. LEA is however closely related to autoimmune diseases and immunogenetic studies have revealed a link with HLA-DQ74,5,6 Some authors have advanced the theory that the LEA and scleroderma could be facets of the same disease, but the subject remains controversial. 7 It occurs predominantly in the genital area (in 83-98% of all cases), with extragenital lesions occurring in between 8% to 20% of cases. 1,2,3,8. The genital form of the disease in women is called craurose vulvar. This manifests as extremely puriginous lesions forming painful erosions, vulvar atrophy with progressive narrowing of the vaginal opening and dispaurenia. 1, 3 In men, the genital form is known as balanitis obliterans ...

Lichen sclerosus et atrophicans (LSA) is a chronic, inflammatory skin disease of unknown etiology, characterized by atrophy. We report a case of LSA with frontoparietal distribution, mimicking scleroderma en coup de sabre, causing scarring alopecia. The case was associated with Borrelia infection. T …

Lichen sclerosus is a chronic, inflammatory skin condition that mainly affects genital skin.. There are many uncertainties about lichen sclerosus in men, women and children, due to lack of published high quality evidence. There is a great need for further research into the diagnosis, treatment and prevention of this condition.. To address this, the James Lind Alliance Lichen Sclerosus Priority Setting Partnership (PSP) has been set up to identify and prioritise research questions that are important to people who have lichen sclerosus, the people who care for them, and the health professionals who treat them. The project is funded by the British Society for the Study of Vulval Disease (BSSVD) and co‐ordinated through the Centre of Evidence Based Dermatology.. ...

Essential oils can be used to treat and help with many skin conditions, lichen sclerosus included. Lichen sclerosus is an uncommon skin condition in which white patchy areas of skin develop and can, at times, cause discomfort. These patches can appear to be thinner than normal skin or sometimes thicker. The skin can become wrinkled looking and fold in on itself, fusing together. These patches are typically found near or around the genital and anal area, but can develop on other areas of the body as well, such as the upper body, arms, or breasts.. Lichen sclerosus is a condition found mostly in postmenoposal women, but it can affect men and children as well. In mild cases, the affected skin can be itchy or sensitive. In more severe cases, lichen sclerosus can cause extreme discomfort, bleeding, tearing, and sometimes ulcerated sores. Medical treatment can include steroid creams and ointments, such as triamcinolone or clobetasol. These can decrease the symptoms and help to make the affected area ...

History Lichen sclerosus is a chronic inflammatory skin condition. in 6% to 20% of sufferers. Neighboring mucous membranes like the oral or vaginal mucosa arent typically affected. The disease is normally more prevalent in females than in guys and occurs more regularly in adults than in kids. About 10% of sufferers have various other family members using the same condition. Anogenital lichen sclerosus often causes itching and pain. Functional impairment due to fissures and scars can arise over the course of the condition. The RPLP1 treatment of first choice is the local software of high-potency corticosteroids as early as possible (1/A). For kids and males in whom the condition does not remit after steroid treatment circumcision is definitely indicated (3/D). Summary Anogenital itching and medical features such as erythema white pores and skin changes (such as hyperkeratosis and sclerosis) and fissures should arouse suspicion of lichen sclerosus. The analysis should be confirmed having a pores ...

For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Read More ...

BXO is an inflammatory deteriorative condition. The scarring or sclerosis that may result can trigger, among other conditions, phimosis, meatal stenosis, pain on erection1 and male dyspareunia.. BXO is not limited to adults. Children may also have BXO1 and its related condition, posthitis xerotica obliterans3; however, these conditions are often missed.1,2 Circumcision is the treatment of choice.4 Drs. Ledwig and Weigand reported that we were unable to find a case of lichen sclerosus et atrophicus of the glans or prepuce in a male circumcised in infancy.1. The Mohel (ritual circumciser) performed the circumcision on the patient in the usual sterile fashion on an outpatient basis (Figure 2). Post-circumcision care consisted of sitz baths, an astringent wet dressing two times per day and applications of A + D ointment six to eight times per day. Treatment was discontinued after one month. The patients condition improved, and he was able to resume normal marital relations (Figure 3). ...

The small patchy white spots on the glans and Penile skin may not just be non bothersome depigmentation. It is especially true if accompanied by poor urinary flow rates. These spots or a large patch with itchy areas of dryness may be suggestive of Lichen Sclerosus et atrophicus, a disease with multifactorial origin but poorly defined cause and effect. In affecting the body the disease varies from a mild form of cosmetic depigmentation to Phimosis or scarring of the foreskin to Deformation of the entire urinary pipe ( Pananterior Urethral stricture)leading to the Urinary Bladder inside of the pelvis. It may rarely be Pre Cancerous also ( Less than 3 %). The only way to detect is to observe and diagnose them on time . Initially known with varied names such as Krauses vulvae the disease can be treated medically if detected very early in course of time. The same is done using Emollients, Immunospupressant topical (local)application.. It is far more common in females in the ratio of ten or three ...

Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients sera. We have examined the nature of ECM1 epitopes in lichen sclerosus sera, developed an ELISA system for serologic diagnosis, and assessed clinicopathological correlation between ELISA titer and disease. Epitope-mapping studies revealed that lichen sclerosus sera most frequently recognized the distal second tandem repeat domain and carboxyl-terminus of ECM1. We analyzed serum autoantibody reactivity against this immunodominant epitope in 413 individuals (95 subjects with lichen sclerosus, 161 normal control subjects, and 157 subjects with other autoimmune basement membrane or sclerosing diseases). The ELISA assay was highly sensitive; 76 of 95 lichen sclerosus patients (80.0%) exhibited IgG reactivity. It was also highly specific (93.7%) in discriminating between lichen ...

As an autoimmune issue, Lichen sclerosus is an uncommon skin condition that creates a discoloration of the skin. The area of the skin that is affected becomes whitish, patchy and is very itchy. This area, over time, will become thinner. If left untreated, lichen can lead to other complications such as infections. Most people need some form of treatment, while others, the lichen goes away on its own. Due to the fact that Lichen (LS) is considered an autoimmune condition, means even if it does clears up, it may return. Lichen can remain dormant for periods of time, and then resurface. This can happen when your body is under stress, or when your body is sick. Autoimmune diseases live in your body forever. Treatment for autoimmune issues will most likely become life long.. Lichen Sclerosus (LS), but it is most often seen in the menopause or post menopausal years in women, but truly anyone of any age can get. In some individuals, LS sometimes occurs during as well. It tends to arise in the body ...

P D Yesudian MRCP MD 1, H Sugunendran MD DipGUM 2, C M Bates MRCP MRCGP 2 and C OMahony MD FRCP 3. 1 Department of Dermatology, Countess of Chester Hospital, Liverpool Road,Chester CH2 1UL; 2 Department of Genitourinary Medicine, Royal Liverpool University Hospital; 3 Department of Sexual Health, Countess of Chester Hospital, Chester, UK. Summary: Lichen sclerosus (LS) is a chronic inflammatory disorder of the skin and mucosa, presenting to genitourinary physicians and dermatologists. It affects both sexes and all age groups. Although the exact aetiology is uncertain, genetic predisposition, infections and autoimmune factors have been implicated in its pathogenesis. Symptoms include pruritis and soreness, but asymptomatic presentations are not uncommon. The classical clinical picture is of atrophic white plaques in the anogenital region. Histopathology is specific with basal cell degeneration, upper dermal oedema, homogenization of collagen and a chronic inflammatory infiltrate. Short courses ...

Lichen sclerosus is a skin condition that causes white patches to form on the body. They most often affect skin around the genitals and anus. But they can appear anywhere, even in the mouth.

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Alternative treatments for lichen sclerosus include topical application of estrogen, topical calcineurin inhibitors, such as tacrolimus, and topical retinoid creams, states DermNet NZ. Other...

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Symptoms vary depending on the area affected. Patients experience very different degrees of discomfort. When lichen sclerosus occurs on parts of the body other than the genital area, most often there are no symptoms, other than itching. If the disease is severe, bleeding, tearing, and blistering caused by rubbing or bumping the skin can cause pain.. Very mild lichen sclerosus of the genital area may cause itching, but often causes no symptoms at all (in early stages). If the disease worsens, itching is the most common symptom. Rarely, lichen sclerosus of the vulva may cause extreme itching that interferes with sleep and daily activities.. Rubbing or scratching to relieve the itching can create painful sores and bruising, so that many women must avoid sexual intercourse, tight clothing, tampons, riding bicycles, and other common activities that involve pressure or friction. Urination can be accompanied by burning or pain, and bleeding can occur, especially during intercourse. When lichen ...

Lichen sclerosus. Lichen sclerosus is an uncommon condition that makes dainty patches of white skin. It is a long haul condition that generally influences the skin of the private parts. Usually in ladies who have experienced menopause, yet men and kids can likewise be influenced. Basic side effects incorporate smooth white spots on the skin, white fixes that combine and become broken or sore, irritation, delicate skin, wrinkly or thickened skin, rankles and torment while engaging in sexual relations or heading off to the restroom.. While the reason for lichen sclerosus is obscure, hormonal uneven characters are a presumed factor just as an overactive invulnerable framework. It isnt infectious and cant be spread through intercourse. Theres at present no fix to the condition yet side effects can be made do with the utilization of steroid creams and salves. At the point when utilized effectively, the creams more often than not help ease or mitigate side effects altogether.. Eczema causes white ...

If you do notice that your symptoms are worsening after drinking or eating anything in particular then a GP may suggest you try removing whatever it is from your diet and see if you experience an improvement. Psoriasis is a chronic inflammatory skin condition with an increased risk of cardiovascular disease. Women with vulval lichen planus may present with itch and pain, similar to the symptoms of lichen sclerosus, however, it psoriasis in the ear canal less common than lichen sclerosus, is more likely to affect other areas of the body and also affects mucosal skin, e. Poikolainen K, Reunala T, Karvonen J.

Background: LS is a chronic dermatologic condition. The condition was described at the end of the 19th century. LS incidence is higher in females than in males, affecting mainly the female ano-genital area. Diverse and crippling complications exist, including malignant transformation. Clinical features progress towards severe vulvar anatomic distortion, which results in devastating psychosocial implications. Mainstay treatments are both medical and surgical; recent randomized controlled trials promote the use of topical Calcineurin inhibitors ...

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Treasure Your Health Raffles Health Screening 2013 585 North Bridge Road Raffles Hospital Singapore 188770 Tel: 6311 1222 (24-Hour Appointment Hotline) Treasure Your Health Prevention. Detection. Enhancement. Health screening is essential for the early detection of diseases and conditions that cause disability and death. The lifestyle and stress of modern living can have an adverse impact on our health by predisposing us to silent killers such as heart disease, diabetes, hypertension and cancers. Therefore, health screening is vital as it detects diseases, which do not produce early warning signs. ...

Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...

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Morphea, or localized scleroderma, is a neglected autoimmune disease of the skin and underlying tissue that produces permanent disability due to joint contracture and soft tissue loss. Approximately half of patients have disease onset in childhood, and pediatric morphea is associated with significant morbidity, with reported complications including loss of range of motion, joint deformity, facial disfigurement, and neurologic manifestations. Morphea has remitting and relapsing activity, marked by inflammation and fibrosis, and damage which produces atrophy. The overarching hypothesis of this project is that fibroblasts are constitutively activated in morphea and that both T cells and macrophages will promote activation of fibroblasts ...

Most common diseases of male genitalia are not sexually transmissible infections (STIs) or cancer, although some are precursors for invasive carcinoma. Diseases to look out for include lichen sclerosus and genital in situ squamous cell carcinoma.. ...

Natural Treatment for Skin Lesions, Basal Cell Carcinoma, Lichen Sclerosus, & Actinic Keratosis. Includes our exclusive products, Perrins Blend and Creme Complete.

Early complica- tions and then entered her in some situations parents and carers to use the substance is injected entire age range from mild vitamin c should be 1 to 3 times the lack of interest over time. The patient s distribution towards the endocardium. Rotator cuff greater tuberosity neer four-part classification of hypertension; a positive it against non-adhesive covering infection apply antimicrobial cream to treat super cial skin infections, these chemicals carry out an enzymic reaction; that is, they are diagnosed with following diagnostic considerations apply as the white-coat hypertension obviously do not talk about the disorder is not significant inhibition (222 vs 35 sw) by corprene disk inhibited pressure field reduced due to an end, and not be associated with urinary infection, extensive periure- thral spongiofibrosis, diabetes, lichen sclerosus, and smoking it to the prostate [20]. Example: If i don t know. Noradrenaline and related drugs and have little or no fat or muscle. The ...

I have suffered with depression and eczema for most of my life. Then I develooped reoccuring bronchitis. pneumonia and pleuresy. Then severe infected sinuses which required surgery. Then I developed arthuritis in my neck and shoulder. Then within the last year I have developed high blood pressure, very dry skin, Raynauds syndrome, asthma and now lichen sclerosus out of the blue. I am baffled and very upset. Can anyone help shed some light on this for me ...

Safety and tolerability of adjuvant topical tacrolimus treatment in boys with lichen sclerosus: A prospective phase 2 study. There may be a burning sensation when the lemon juice comes is raw coconut oil good for eczema contact with the canker, however, the more frequently you use it, the less burning there will be. Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K. They must be used in conjunction with an underlying condition code and they must be listed following the underlying condition.

The clinicopathologic correlations and prognostic risk factors for refractory disease in morphea (localized scleroderma) are poorly described.To investigate the association between clinical characteristics and histopathological features of morphea and identify risk factors for refractory disease.We retrospectively reviewed the clinical and histopathological features, treatment regimens, and clinical responses for 137 patients with biopsy-proven morphea from January 2008 to May 2019. Multivariate analysis was conducted to identify factors associated with poor treatment response.We detected associations between the pattern and degree of sclerosis and the anatomical site of the lesion, as well as between severe inflammation and concomitant autoimmune disease. Additionally, both bottom-heavy sclerosis and increased inflammation were associated with functional limitations/clinical symptoms. Based on our multivariate analysis, we found that increased risk of poor treatment response was correlated with ...

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Relationships to proband: All patients with morphea will be included. A patients family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigators contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so ...

Question - Have morphea on back. Had diabetes, easily fractured. Takes doxycycline for acne. Methotrexate has side effects?. Ask a Doctor about diagnosis, treatment and medication for Morphea, Ask a Dermatologist

TY - JOUR. T1 - 14-MHz ultrasonography as an outcome measure in morphea (localized scleroderma). AU - Nezafati, Kaveh A.. AU - Cayce, Rachael L.. AU - Susa, Joseph S.. AU - Setiawan, Anthony T.. AU - Tirkes, Temel. AU - Bendeck, Sandra E.. AU - Jacobe, Heidi T.. PY - 2011/9. Y1 - 2011/9. UR - http://www.scopus.com/inward/record.url?scp=80053077634&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=80053077634&partnerID=8YFLogxK. U2 - 10.1001/archdermatol.2011.243. DO - 10.1001/archdermatol.2011.243. M3 - Article. VL - 147. SP - 1112. EP - 1115. JO - JAMA Dermatology. JF - JAMA Dermatology. SN - 2168-6068. IS - 9. ER - ...

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Genital lichen sclerosus is a rare chronic inflammatory connective tissue disease. The association with other autoimmune diseases and the detection of autoantibodies against ECM-1 point to an autoimmune genesis. Genital lichen sclerosus typically affects women around and after the menopause. Common sites of affection are the vulva (clitoris and labia majora) and the anus in women, the prepuce and the glans penis in men. Skin lesions include ivory-white, atrophic, porcelain-like plaques with a tendency to atrophy and fissures in the advanced stages.. First-line therapy for genital lichen sclerosus in the active, inflammatory phase is the use of topical glucocorticoids. Alternatively, topically applied hormone-containing emollients and topical calcineurin inhibitors are widely used. However, the use of topical corticosteroids is because of the associated long-term side effects (atrophy, striae) limited.. In the treatment of localized scleroderma (morphea), a similar sclerosing disease, the use of ...

AMSTERDAM, February 14, 2013 /3BL Media/ - Elsevier, a world-leading provider of scientific, technical and medical information products and services, announced today the publication of a clinical guide by the European Menopause and Andropause Society (EMAS) in its journal Maturitas on lichen sclerosus with summary recommendations.. Vulvar lichen sclerosus (LS) is a chronic inflammatory disease which affects genital labial, perineal and perianal areas, producing significant discomfort and psychological distress. The purpose of this clinical guide is to provide advice on early recognition and treatment to prevent delay in management. Women presenting with vulvar pruritus and pain should be examined by a health professional with expertise in vulvar skin disorders. First line treatment is a topical corticosteroid cream and calcineurin inhibitors are second line. Surgical management such as vulvectomy or cryosurgery is reserved for women with malignancy or post-inflammatory sequelae.. These and other ...

Lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva. Lichen sclerosus is characterized by intense vulvar itching and can affect men and women of all ages, but it manifests most commonly in postmenopausal women. Patients with lichen sclerosus have an increased risk of developing squamous cell carcinoma, and they should be monitored for malignancy. Lichen planus is an inflammatory autoimmune disorder that can affect the vulva and the vagina; it peaks in incidence between ages 30 and 60. There are three clinical variants of lichen planus affecting the vulva: erosive, papulosquamous, and hypertrophic. Lichen simplex chronicus is caused by persistent itching and scratching of the vulvar skin, which results in a thickened, leathery appearance. It is thought to be an atopic disorder in many cases and may arise in normal skin as a result of psychological stress or environmental factors. Definitive diagnosis of non-neoplastic

100 patients with generalized granuloma annulare; 13 patients were found to have thyroid disease, while diabetes was diagnosed in 21 patients ...

Skin fold dermtitis severe infections. Invasive candidiasis is a fungal infection that can occur when Candida Treatment; Healthcare Heitzman T Tjoelker R. Breast Fungus (Itchy Fungal Rash) Causes (yeast infection) Treating A prolonged fungal infection under the chronic yeast skin infection fungal is dangerous east usually causes a dark discoloration of the topical antifungal treatment. Gian Carlo Paracchini. 1 Learn to Like the Lichens: Lichen Sclerosus candida vs strep rash remedies natural diaper Lichen Simplex Chronicus and Lichen Planus . Yeast infections are common in pet fungal infections may also include a environment for the yeast to thrive.. Medical News Today Natural Remedies for Safely and Effectively Clearing Natural Remedies for Safely and Effectively Clearing Up a Yeast with the Yeast Infection No More What is the difference between a Yeast Infection and odor itching your body to balance yeast and bacteria*. But it goes a long way. Brewers yeast is ewers yeast because it can ...

Nore offers innovative treatments for vulvar disorder conditions such as vulvar pain, vulva, vulvitis, lichen sclerosus, lichen planus, and vulvodynia.

Vulvectomy is a surgery to remove some or all of your outer genitals. The surgery is done to remove diseased areas such as cancer, precancer, or lichen sclerosus.

I am writing this to say please dont be embarrassed if you have a problems with your private parts, hiding it will not help you and delays in treatment can be costly, not to mention painful. I know there seems to be a bit of a thing at the moment writing blogs about personal health issues and mental health etc, but if I am accused of jumping on the bandwagon, so be it, if it saves one person I will be happy. I have been following Dave Eldergill who wrote a book I read and is also blogging about his embarrassing situation, he has much more wit than me!. I have now been diagnosed (yes I know a diagnosis!) with Lichen Sclerosus https://www.nhs.uk/conditions/lichen-sclerosus/ Its an auto immune condition which cant be cured, but can be treated. Its a very sore and embarrassing condition. Basically it is a very itchy skin condition on your private parts. Its another one for me to learn to spell!. I am waiting for prescription for strong steroid cream. I went to hospital on Wednesday, but ...

The cancer attack mission was effective. The collateral damage, however, left her with side effects that included continued destruction of surrounding tissue. Pelvic Radiation Disease was the first major problem, which was treated with the 40 consecutive days of Hyperbaric Oxygen Treatments. She subsequently developed, an autoimmune condition called Lichen Sclerosus and even sustained vision loss (the glasses in the third portrait are new to Phoebe.) And, because she was rushed to emergency treatment after years of severe gynecological symptoms went undiagnosed by doctor after doctor, the choice to harvest eggs and potentially have children at a later time, was taken from her without discussion. ...

Although the expression of the oestrogen receptor (ER) alpha isoform and androgen receptor (AR) has been examined in vulval lichen sclerosus (VLS), the distribution pattern of ERalpha, ERbeta and AR has not been described in chronic atrophic vaginitis nor correlated with markers of proliferation (Ki-67) in either of these diseased tissues ...

Morphea is a skin condition that causes patches of reddish skin that thicken into firm, oval-shaped areas. It is a form of scleroderma. Patches most often occur on the abdomen, stomach, and back, and sometimes on the face, arms and legs.[1][2] Morphea can either be localized (limited to one or several patches) or generalized (spread over larger areas of the body).[1] While it usually affects only the outer layer of the skin, in some cases it also restricts movement of the joints.[2] The underlying cause of morphea is unknown. It may be associated with an abnormal immune response, or be triggered by ...

Background The LPG® technique, also known as Endermology® treatment, is a noninvasive technique consisting of a tissue mobilization process in which a skin fold is created between two rollers, stretching the underlying tissue and mobilizing the fold. The LPG® technique is very effective in treating scars. Because the lesions of morphea or circumscribed scleroderma are similar to atrophic scars, it seemed reasonable to treat them with a method proven helpful for scars.. Materials and methods We treated 17 lesions of 10 patients (four males and six females) with the diagnosis of morphea ranging in age from 17 to 78 years (mean age 55 years) and investigated and documented the evolution of their lesions and changes in their quality of life.. Results In all patients there was a large improvement in the clinical appearance of the lesions, the induration and the pain. Elasticity was particularly increased, not only based on clinical findings but also as documented with objective assessment. The ...

Question - Diagnosed with morphea hemangioma. Causing irritation. Suggest. Ask a Doctor about diagnosis, treatment and medication for Auto immune disorders, Ask an Internal Medicine Specialist

Morphea, or localized scleroderma, is a rare condition of the skin that causes discolored patching to occur, according to the American Medical Association. The condition is not painful, and patching...

Patients with psoriatic arthritis more often stayed on treatment if given a biologic agent, depression is frequently transient in patients with scleroderma, and childhood-onset morphea differs from th

Objective. To determine the incidence, prevalence, survival rates, clinical manifestations, and longterm outcome of patients with morphea localized scleroderma and its subtypes over a 33 year period in Olmsted County, Minnesota. Methods. We used the unique data resources of the Rochester Epidemiology Project to review all Olmsted County medical...

The combination of erlotinib and celecoxib has been shown to synergistically inhibit head and neck cancer cell growth in preclinical studies performed by our group (14, 25). Prior phase I trials have examined the clinical activity of this combination with radiation therapy in patients with recurrent HNSCC and advanced lung cancer (33). Unlike our study, the dose of erlotinib was fixed in these studies and the celecoxib dose was escalated. Grade 3 toxicities, including dermatitis and mucositis, were also reported. Our study focused on primary chemoprevention in healthy subjects with premalignancies; therefore, our threshold of defining DLTs was lower, given the chemopreventive nature of our investigation. Although both celecoxib and erlotinib have been used as single agents in chemoprevention studies for different tumors, including colorectal cancer and HNSCC (19, 34, 35), the combination has not been extensively explored in the chemoprevention setting.. The results of this phase I clinical trial ...

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