2-Deamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue, Nα-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid, containing p-aminophenylacetic acid residue substituting p-aminobenzoic acid residue, was synthesized. The new analogue exhibited a moderately potent thymidylate synthase inhibition, of linear mixed type vs. the cofactor, N5,10 -methylenetetrahydrofolate. The Ki value of 0.34 μM, determined with a purified recombinant rat hepatoma enzyme, was about 30-fold higher than that reported for inhibition of thymidylate synthase from mouse leukemia L1210 cells by ICI 198583 (Hughes et al., 1990, J. Med. Chem. 33, 3060). Growth of mouse leukemia L5178Y cells was inhibited by the analogue (IC50 = 1.26 μM) 180-fold weaker than by ICI 198583 (IC50 = 6.9 μM ...
TY - JOUR. T1 - A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate. AU - Zhao, Rongbao. AU - Assaraf, Yehuda G.. AU - Goldman, I. David. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1998/4/3. Y1 - 1998/4/3. N2 - With 5-formyltetrahydrofolate (5-CHO-THF) as the folate source a methotrexate (MTX) transport-deficient murine leukemia cell line, L1210-G1a, was isolated after chemical mutagenesis and MTX selection. This cell line was 10-fold resistant to MTX in comparison to parental L1210 cells, yet the EC50 for 5-CHO-THF was increased by a factor of only 2. The initial uptake of MTX, at a concentration of 1 μM, was decreased by a factor of 40, whereas influx of 5-CHO-THF dropped by a factor of only 8. This difference in initial uptake rates was attributed solely to changes in influx V(max) without a significant change in ...
Aim: Leukemia is characterized by uncontrolled marrow cell proliferation and metastatic foci. We investigated the antitumor potential of a nutrient mixture on
Murine leukemia L1210 has been treated with cyclophosphamide and 4 sublines have been developed from the tumor cells surviving drug therapy. Biologic studies have demonstrated a marked alteration of virulence compared to the parent tumor and striking cytogenetic modifications have been found to exist. Serial examinations over an interval of 22 weekly transplant generations have demonstrated a biologic and cytogenetic instability characterized by, generally, a tendency for return toward control values.. ...
Kessel, D, Effects of camptothecin on rna synthesis in leukemia l1210 cells. (1971). Subject Strain Bibliography 1971. 891 ...
Reif, A E. and Kim, C H., Leukemia l1210 therapy trials with antileukemia serum and bacillus calmette-guerin. (1971). Subject Strain Bibliography 1971. 1532 ...
In this study therapeutic synergism was observed in combination chemotherapy of leukemia L5178Y with L-asparaginase (A-Ase) plus methotrexate (MTX) over a variety of treatment schedules. Therapeutic synergism occurred when a single dose of A-Ase was followed at varying times (immediately or up to 6 hr later) by daily treatment with MTX. It was also observed when daily treatment with MTX was initiated just prior to or up to 6 hr before a single treatment with A-Ase. Similarly, increases in survival time were observed in leukemic mice when daily treatment with MTX was initiated 4 days prior to a single dose of A-Ase on Day 7. In one instance, the occurrence of therapeutic synergism was dependent upon the sequence of drug administration. Whereas therapeutic synergism was observed when mice bearing L5178Y leukemia were given 5 daily treatments of MTX followed 3 days later by 5 daily treatments of A-Ase; it did not occur when A-Ase preceded MTX on the same schedule. Treatment with MTX was found to be ...
BioAssay record AID 96953 submitted by ChEMBL: Activity against cultured L1210 leukemic cells was determined in vitro, after 48 hr of incubation. Compound dose that causes 84 % inhibition was reported.
TIMKEN bearings produce two hundred and thirty kinds of types, twenty-six thousand different specifications of tapered roller bearings, which are widely used in countries around the world. TIMKEN bearings is widely used, whether it is a family car wheel hub assembly, bearing roller coaster rail bearing repair services, aircraft engines or steel .... ...
d-r. Jagoda Dimitrievska. d-r. Dragica Vasileva. d-r. Lidija Ristovska. Violeta Stoilkovska. Mimica Janeva. Snezana Boycin. Ana Popovska Gigovska. Vesna Petkovska. Sonja Chadikovska. Suzana Kimevska Kerimova. Sokica Ilievska. Alexandra Adams. Silvana Blazevic. Vera Chadikovska. ...
TY - JOUR. T1 - Standardization of the alkaline elution procedure using X-ray-damaged nuclear DNA. AU - Bolognesi, C.. AU - Cesarone, C. F.. AU - Santi, L.. PY - 1979. Y1 - 1979. UR - http://www.scopus.com/inward/record.url?scp=0018600110&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018600110&partnerID=8YFLogxK. M3 - Article. C2 - 42176. AN - SCOPUS:0018600110. VL - 65. SP - 511. EP - 516. JO - Tumori. JF - Tumori. SN - 0300-8916. IS - 5. ER - ...
Background and Objectives: This study was designed to examine modes of cell death after photodynamic therapy (PDT). Study Design: Murine leukemia L1210 cells and human prostate Bax-deficient DU145 cells were examined after PDT-induced photodamage to the endoplasmic reticulum (ER). Phase contrast, fluorescence and electron microscopy were used to identify changes in cellular morphology, chromatin condensation, loss of mitochondrial membrane potential, and formation of phagolysosomes. Western blots were used to assess the processing of LC3-I to LC3-II, a marker for autophagy. Inhibitors of apoptosis and/or autophagy were used to delineate the contributions of the two pathways to the effects of PDT. Results: Both apoptosis and autophagy occurred in L1210 after ER photodamage with the latter predominating after 24 hours. In DU145 cells, PDT conditions causing comparable cytotoxicity only initiated autophagy. PI3-kinase inhibitors suppressed autophagy in both cell lines as indicated by inhibition of
Tumor cell-based vaccines are currently used in clinical trails, but they are in general poorly immunogenic because they are composed of cell extracts or apoptotic cells. Live tumor cells should be much better Ags provided that they are properly processed by the host immune system. We show herein that stable expression of a small hairpin RNA for ERK5 (shERK5) decreases ERK5 levels in human and mouse leukemic cells and leads to their elimination by NK cells in vivo. The shERK5 cells show down-regulation of MHC class I expression at the plasma membrane. Accordingly, ectopic activation of the ERK5 pathway induces MHC class I gene expression. Coinjection of shERK5-expressing cells into the peritoneum diminishes survival of engrafted wild-type tumor cells. Moreover, s.c. injection of shERK5-expressing cells strongly diminishes tumor development by wild-type cells. Our results show that shERK5 expression in leukemia cells effectively attenuates their tumor activity and allows their use as a tumor cell-based
Ia8, a cell membrane antigen controlled by gene(s) located in the I region of the H-2 complex, was found on 9 of 26 murine leukemia cell lines. In addition, 3 of the 9 Ia8-bearing lines had a membrane receptor for antigen-antibody-complement complexes. Six of 26 lines bore the Thy-1.2 antigen. Ia8 and Thy-1.2 antigens were mutually exclusive on the cell lines studied. The strain of virus used to induce the leukemia, the H-2 type of the cells, and the techniques of leukemia cell propagation all appeared to influence the antigenic characteristics of the cell lines obtained. Production of infectious murine leukemia virus in vitro and expression of leukemia virus-induced membrane antigens did not appear to correlate with the presence of Ia8 or Thy-1.2 antigens or with the H-2 type of the cells.. ...
The immunotoxic responses of allogeneic B6C3F1-mice and syngeneic CD2F1-mice bearing L1210 mouse leukemia to ethylene-glycol- monomethyl-ether (109864) (EGME) and ethylene-glycol-monoethyl-ether (110805) (EGEE) were investigated. B6C3F1-mice received oral doses of 600, 1,200 or 2,400 milligrams per kilogram (mg/kg) EGEE, or 300, 600, or 1,200mg/kg EGME 12 to 8 days prior to tumor transplantation,
Gross Axle Wt Rating - Front - 7000 lbs ((99T&68M&47L),(99T&68M&47J),(99T&68M&473),(99T&68M&47A)), 7000 lbs ((99T&((68D-R,68D-F)&47L)),((99T&((68D-R,68D-F)&47J)),((99T&((68D-R,68D-F)&473)),(99T&((68D-R,68D-F)&47A))))), 7000 lbs ((99T&47L),(99T&47J),(99T&473),(99T&47A)), 6500 lbs (473&((99Y-R,99Y-F)&68U)), 5600 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67X)), 6000 lbs ((99Y-R,99Y-F)&(67H&68U)), 7500 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67P)), 5200 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67H)), 6500 lbs ((99Y-R,99Y-F)&(67X&68U)), 6500 lbs (473&((99Y-R,99Y-F)&(68D-R,68D-F))), 7500 lbs ((99Y-R,99Y-F)&(67P&68U)), 6000 lbs (99T&((68D-R,68D-F)&67X)), 6000 lbs (99T&67X&68M), 7500 lbs (99T&((68D-R,68D-F)&67P)), 5600 lbs (99T&((68D-R,68D-F)&67H)), 7500 lbs (99T&67P&68M), 5600 lbs (99T&67H&68M), 5200 lbs (99T&660A), 5200 lbs ((99Y-R,99Y-F)&67H), 7500 lbs ((99Y-R,99Y-F)&67P), 6500 lbs (473&(99Y-R,99Y-F)), 5600 lbs ((99Y-R,99Y-F)&68U), 5600 lbs ((99Y-R,99Y-F)&67X), 5200 lbs (99T&(68D-R,68D-F)), 5600 lbs (99T&67H), 5200 lbs ...
Gross Axle Wt Rating - Front - 7000 lbs ((99T&68M&47L),(99T&68M&47J),(99T&68M&473),(99T&68M&47A)), 7000 lbs ((99T&((68D-R,68D-F)&47L)),((99T&((68D-R,68D-F)&47J)),((99T&((68D-R,68D-F)&473)),(99T&((68D-R,68D-F)&47A))))), 7000 lbs ((99T&47L),(99T&47J),(99T&473),(99T&47A)), 7500 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67P)), 6500 lbs (473&((99Y-R,99Y-F)&(68D-R,68D-F))), 7500 lbs (99T&((68D-R,68D-F)&67P)), 7500 lbs (99T&67P&68M), 7500 lbs ((99Y-R,99Y-F)&67P), 6500 lbs (473&(99Y-R,99Y-F)), 7500 lbs (99T&67P), 7500 lbs (67P), 7000 lbs (47A), 7000 lbs (47L), 7000 lbs (47J), 6000 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67X)), 6500 lbs (473&((99Y-R,99Y-F)&68M)), 7500 lbs ((99Y-R,99Y-F)&(67P&68M)), 5600 lbs ((99Y-R,99Y-F)&((68D-R,68D-F)&67H)), 6500 lbs (99T&((68D-R,68D-F)&67X)), 6500 lbs (99T&67X&68M), 6000 lbs (99T&((68D-R,68D-F)&67H)), 6000 lbs (99T&67H&68M), 5600 lbs ((99Y-R,99Y-F)&67H), 6000 lbs ((99Y-R,99Y-F)&67X), 5600 lbs (99T&(68D-R,68D-F)), 6000 lbs (99T&67H), 5600 lbs (99T&68M), 6500 lbs (99T&67X), 5200 lbs, ...
Dwarf, low mounding gold shrub proven to be burn resistant in summer sun. New growth emerges red and turns red again in the fall. A Proven Winners Color Choice(R) introduction bred in Poland.
Angiogenesis is the formation of new blood vessels from existing vasculature critical for embryonic development and vascular remodeling. trusted to relieve a variety of symptoms including exhaustion and malaria, and it is further thought in Malagasy traditional medication to obtain anticancer and antiviral properties [14, 15]. Preliminary research of isolated derivatives determined capsicodendrin (CPCD) being a lead substance that was extremely soluble and steady in aqueous environment, and with the capacity of exerting cytostatic activity against a wide spectrum of tumor cell types including murine Leukemia cells (L1210/0), individual T-lymphocyte cells (Molt4/C8 and CEM/0), HeLa and HT29 cells at sub-micromolar runs [16]. Many chemotherapeutic agencies have anti-angiogenic properties because they generate cytotoxic or cytostatic results by targeting mobile pathways that promote apoptosis or autophagy [17, 18]. The last mentioned process has very clear roles in a variety of mobile and ...
Angiogenesis is the formation of new blood vessels from existing vasculature critical for embryonic development and vascular remodeling. trusted to relieve a variety of symptoms including exhaustion and malaria, and it is further thought in Malagasy traditional medication to obtain anticancer and antiviral properties [14, 15]. Preliminary research of isolated derivatives determined capsicodendrin (CPCD) being a lead substance that was extremely soluble and steady in aqueous environment, and with the capacity of exerting cytostatic activity against a wide spectrum of tumor cell types including murine Leukemia cells (L1210/0), individual T-lymphocyte cells (Molt4/C8 and CEM/0), HeLa and HT29 cells at sub-micromolar runs [16]. Many chemotherapeutic agencies have anti-angiogenic properties because they generate cytotoxic or cytostatic results by targeting mobile pathways that promote apoptosis or autophagy [17, 18]. The last mentioned process has very clear roles in a variety of mobile and ...
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Doc. d-r Vladimir Trajkovski Kumanovo, maj 2005 1 ...10 2 .....................SODR@INA: 1........................................................................... KORISTENA LITERATURA..............................................................VOVED........................2 2..............3 5.....................................................................................................................3 3............ SINONIMNI I NESINONIMNI SUPSTITUCII................................................... GENSKI MUTACII.....................3 4...................................................... STAPKA NA NUKLEIDNI SUPSTITUCII....................................................................................9 8.................. ZAKLU^OK....................................................................................6 6.......7 7.............................. SUPTITUCIONI MUTACII...................... INSERCIJA I DELECIJA.............. ili razni nepravilnosti koi se slu~uvaat vo tekot ...
University of South Carolina, providing technology, course design and student support for academic departments and colleges to deliver courses at a distance.
We describe herein a concise synthesis of (+)-neopeltolide, a marine macrolide natural product that elicits a highly potent antiproliferative activity against several human cancer cell lines. Our synthesis exploited the powerful bond-forming ability and high functional group compatibility of olefin metathesis and esterification reactions to minimize manipulations of oxygen functionalities and to maximize synthetic convergency. Our findings include a chemoselective olefin cross-metathesis reaction directed by H-bonding, and a ring-closing metathesis conducted under non-high dilution conditions. Moreover, we developed a 16-member stereoisomer library of 8,9-dehydroneopeltolide to systematically explore the stereostructure-activity relationships. Assessment of the antiproliferative activity of the stereoisomers against A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HT-1080 human fibrosarcoma, and P388 murine leukemia cell lines has revealed marked differences in potency between ...
It has been reported that the activation of dihydrofolate reductase (DHFR) from L1210 mouse leukaemia cells by KCl or thiol modifiers is accompanied by increased digestibility by proteinases [Duffy, Beckman, Peterson, Vitols and Huennekens (1987) J. Biol. Chem. 262, 7028-7033], suggesting a loosening up of the general compact structure of the enzyme. In the present study, the peptide fragments liberated from the chicken liver enzyme by digestion with trypsin in dilute solutions of urea or guanidine hydrochloride (GuHCl) have been separated by FPLC and sequenced. The sequences obtained are unique when compared with the known sequence of DHFR and thus allow the points of proteolytic cleavage identified for the urea- and GuHCl-activated enzyme to be at or near the active site. It was also indicated by the enhanced fluorescence of 2-p-toluidinylnaphthalene 6-sulphonate that conformational changes at the active site in dilute GuHCl parallel GuHCl activation. The above results indicate that the ...
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MacDowell, Edwin Carleton (January 1955) Mouse leukemia. XV. Resistance to spontaneous cases in hybrids, induced by milk. Cancer Research, 15 (1). pp. 19-22. MacDowell, Edwin Carleton (January 1955) Mouse leukemia. XVI. Spontaneous cases in strain C58 resisted by milk of old STOLI foster nurses. Cancer Research, 15 (1). pp. 23-25. Bhaskar, Surindar Nath, Schour, Isaac, MacDowell, Edwin Carleton, Weinmann, Joseph Peter (June 1951) The skull and the dentition of screw tail mice. The Anatomical Record, 110 (2). pp. 199-229. MacDowell, E. Carleton (February 1950) Light- a new mouse color. The Journal of Heredity, 41 (2). pp. 35-36. Taylor, Martha J., MacDowell, E. Carleton (March 1949) Mouse leukemia. XIV. Freeing transplanted line I from a contaminating virus. Cancer Research, 9 (3). pp. 144-149. MacDowell, Edwin Carleton, Taylor, Martha J. (1948) Mouse leukemia. XIII. A maternal influence that lowers the incidence of spontaneous cases. Proceedings of the Society for Experimental Biology and ...
Supplementary Materialsba026054-suppl1. proteins-9 nuclease (Cas9) negative-selection testing and discovered a requirement of the catalytic Jumonji (JmjC) area and zinc finger area for leukemia cell success in vitro and in vivo. Furthermore, we discovered that histone H3 lysine 36 methylation (H3K36me) is certainly a marker for JMJD1C activity at gene loci. Furthermore, we performed one cell transcriptome evaluation of mouse leukemia cells harboring an individual information RNA (sgRNA) against the JmjC area and identified elevated activation of RAS/MAPK as well as the JAK-STAT pathway in cells harboring the JmjC sgRNA. We found that upregulation of interleukin 3 (IL-3) receptor genes mediates elevated activation of IL-3 signaling upon JMJD1C reduction or mutation. Along these relative lines, Indoramin D5 we observed level of resistance to JMJD1C reduction in MLLr AML bearing activating RAS mutations, recommending that RAS pathway activation confers level of resistance to JMJD1C reduction. ...
Plasma membranes were isolated by two methods from mouse leukemia cells containing mammary tumor virus-induced (MLr) and normal (Thy.1.2) antigens on their surfaces. A number of chemical components, enzymic activities, and the antigenic contents were determined in subcellular fractions and found to be specifically concentrated in the plasma membrane fractions. The major part of the cellular MLr, in contrast to Thy.1.2, was present in the 105,000 X gmax supernatant of the cell homogenate. This and other results indicate an easy release of the antigen from the plasma membrane. A considerable amount of MLr was also present in the ascites fluid, partly free and partly bound, supposedly in an immune complex that allowed the isolation of three components of similar molecular weights as mammary tumor virus components. The extracellular presence of MLr may illustrate that, by shedding of antigen, the tumor may protect itself against the immunological defense of the host ...
Cylindrical Roller Bearings I n t rod u c t ion Ball Bearings Sph erical Roller Bearings T a p ered Roller Bearings T h r u s t Bearings Sp li t P illo w Bloc k s S u p er P recision Bearings Rolling M ill Bearings L inear M o t ion E ngineering S ec t ion 48 Table of .... ...
Oxaliplatin (Eloxatin) is a 1,2-diaminocyclohexane (DACH) carrier ligand-based groups of platinum antitumor agent with IC50 of median 1.3, 6.2 and 1.5 mM for SW480 .... ...
Monoterpenes are nonnutritive dietary components found in the essential oils of citrus fruits and other plants.. A number of these dietary monoterpenes have antitumor activity.. For example, d-limonene, which comprises ,90% of orange peel oil, has chemopreventive activity against rodent mammary, skin, liver, lung and forestomach cancers. Similarly, other dietary monoterpenes have chemopreventive activity against rat mammary, lung and forestomach cancers when fed during the initiation phase.. In addition, perillyl alcohol has promotion phase chemopreventive activity against rat liver cancer, and geraniol has in vivo antitumor activity against murine leukemia cells. Perillyl alcohol and d-limonene also have chemotherapeutic activity against rodent mammary and pancreatic tumors.. As a result, their cancer chemotherapeutic activities are under evaluation in Phase I clinical trials. Several mechanisms of action may account for the antitumor activities of monoterpenes. The blocking chemopreventive ...
PR domain-containing 14 (Prdm14) is a pluripotency regulator central to embryonic stem cell identity and primordial germ cell specification. Genomic regions containing PRDM14 are often amplified leading to misexpression in human cancer. Prdm14 expression in mouse hematopoietic stem cells (HSC) leads to progenitor cell expansion prior to the development of T-cell acute lymphoblastic leukemia (T-ALL), consistent with PRDM14s role in cancer initiation. Here, we demonstrate mechanistic insight into PRDM14-driven leukemias in vivo. Mass spectrometry revealed novel PRDM14-protein interactions including histone H1, RNA-binding proteins, and the master hematopoietic regulator CBFA2T3. In mouse leukemic cells, CBFA2T3 and PRDM14 associate independently of the related ETO family member CBFA2T2, PRDM14s primary protein partner in pluripotent cells. CBFA2T3 plays crucial roles in HSC self-renewal and lineage commitment, and participates in oncogenic translocations in acute myeloid leukemia. These results ...
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Juba lõppenud projektid on läbi viidud erinevatel uurimissuundadel - võrdlev poliitika, rahvusvahelised suhted ja poliitikateooria. Projekti nime peale klikkides on võimalik tutvuda projekti annotatsiooniga (võimalusel eesti keeles), rahastaja infole klikkimine suunab edasi projekti infolehele.
TY - JOUR. T1 - Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. AU - Jutooru, Indira. AU - Chadalapaka, Gayathri. AU - Lei, Ping. AU - Safe, Stephen. PY - 2010/8/13. Y1 - 2010/8/13. N2 - Curcumin activates diverse anticancer activities that lead to inhibition of cancer cell and tumor growth, induction of apoptosis, and antiangiogenic responses. In this study, we observed that curcumin inhibits Panc28 and L3.6pL pancreatic cancer cell and tumor growth in nude mice bearing L3.6pL cells as xenografts. In addition, curcumin decreased expression of p50 and p65 proteins and NFκB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells. Because both Sp transcription factors and NFκB regulate several common genes such as cyclin D1, survivin, and vascular endothelial growth factor that contribute to the cancer phenotype, we also investigated ...
BOC-Glycine N-hydroxysuccinimide ester, 99%, ACROS Organics™ 5g BOC-Glycine N-hydroxysuccinimide ester, 99%, ACROS Organics™ Amino Acids
TY - JOUR. T1 - In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene. AU - Li, Yong. AU - Yokoi, Tsuyoshi. AU - Katsuki, Motoya. AU - Wang, Jia Sheng. AU - Groopman, John D.. AU - Kamataki, Tetsuya. PY - 1997. Y1 - 1997. N2 - The in vivo activation of aflatoxin B1 (AFB1) was assessed by using two transgenic mouse lines, M2 and M10, in which the human fetus-specific CYP3A7 was expressed in the kidney (M2) and the liver (M10), respectively. Male mice of 8 weeks old from these two lines were treated with a single i.p. injection of AFB1 (4 mg/kg body weight). AFB1-N7-guanine adduct was quantified by high-performance liquid chromatography. DNA damage was measured using the alkaline elution technique 2 and 6 h after AFB1 treatment. Administration of AFB1 resulted in a significantly higher level of AFB1- N7-guanine in the livers of M10 transgenic mice compared with their nontransgenic littermates (16.5 ± 4.2 versus 10.4 ± 1.2 ng/mg DNA, P , 0.01). The level ...
The compound 4-(9-[4-[N-methyl-carboxamido]-5-methyl]acridinylamino)methanesulphon-m-a nisidide and acid addition salts thereof have antitumor properties.
S.C. AMARYLLIS AGROTOUR S.R.L. , 27426068 , J21/342/2010 , Sediu Social: Str Matei Basarab, Nr 68, Bl X, Sc D, Slobozia, jud. Ialomita , Puncte de lucru: Slobozia: Str Matei Basarab, Nr 68, Bl X, Sc D ; Bucuresti: Strada Stockholm, Nr. 19, Sector 1, Licenta de turism nr. 697/12.03.2019 , Brevet de turism nr. 17261/04.11.2010 detinut de Panait Pavel Catalin , Polita de asigurare nr.54981, perioada de asigurare: 05.11.2020 - 04.11.2021, Operator de date cu caracter personal avand numarul de inregistrare 1641 , Autoritatea Nationala pentru Protectia Consumatorilor , Conturi bancare: CEC BANK(RON)- RO09CECEIL0130RON0388084 / BANCA TRANSILVANIA (RON)- RO61BTRLRONCRT0243185901/ BANCA TRANSILVANIA (EUR)- RO11BTRLEURCRT0243185901 ...
See on spetsiaalne silikoon, mida võib panna kuivatisse, autoklaavi, ja mis ei kutsu esile allergiaid, sest ta on tehtud materjalist, millest tehakse lastele mõeldud mänguasju.. Kogu vajalik tootevalik on läbinud testid Milano uuringukeskuses ...
Ligand electronic effects in gold(i) chemistry have been evaluated by means of the experimental determination of M-CO bond dissociation energies for 16 [L-Au-CO]+ complexes, bearing L ligands widely used in gold catalysis. Energy-resolved analyses have been made using tandem mass spectrometry with collision-
DNA alkaline elution is one of the most prominent methods which are currently in use for investigation of the effects of genotoxic agents. The main advantage of this technique is its high sensitivity as well as versatility ...
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Abstract A small particle size formulation of 4-isothiocyanato-4′-nitrodiphenylamine has been found to have high chemotherapeutic activity when administered as a single dose to jirds infected with the filarial worm, Brugia pahangi.
Literature References: Hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. Glycoprotein of mol wt 18-22 kDa; produced in response to specific stimulation by a variety of cells including monocytes, fibroblasts and endothelial cells. Murine and human molecules exhibit cross species reactivity. Originally identified as a differentiation factor for murine leukemic cells. Characterization in mouse serum: J. Lotem et al., Int. J. Cancer 25, 763 (1980); A. W. Burgess, D. Metcalf, ibid. 26, 647 (1980). Purification of murine G-CSF: N. A. Nicola et al., J. Biol. Chem. 258, 9017 (1983); of human G-CSF: K. Welte et al., Proc. Natl. Acad. Sci. USA 82, 1526 (1985); N. Nicola et al., Nature 314, 625 (1985); H. Nomura et al., EMBO J. 5, 871 (1986). Production of human G-CSF by recombinant DNA technology: L. M. Souza et al., Science 232, 61 (1986); S. Nagata et al., Nature 319, 415 (1986). Review ...
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Looking for online definition of Cis-diamminedichloroplatinum in the Medical Dictionary? Cis-diamminedichloroplatinum explanation free. What is Cis-diamminedichloroplatinum? Meaning of Cis-diamminedichloroplatinum medical term. What does Cis-diamminedichloroplatinum mean?
Advanced L5-S1 DDD developed in 69% of deformity patients after long fusions to L5 with 5 to 15 year follow-up. SAD frequently results in significant positive sagittal balance at a minimum 5-year follow-up. Long fusions to the upper thoracic spine down to L5 and circumferential fusion may further pr …
Cytostasis (cyto - cell; stasis - stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell growth. Cytostasis is an important prerequisite for structured multicellular organisms. Without regulation of cell growth and division only unorganized heaps of cells would be possible. Chemotherapy of cancer, treatment of skin diseases and treatment of infections are common use cases of cytostatic drugs. Active hygienic products generally contain cytostatic substances. Cytostatic mechanisms and drugs generally occur together with cytotoxic ones. Nitric oxide - activated macrophages produce large amounts of nitric oxide (NO), which induces both cytostasis and cytotoxicity to tumor cells both in vitro and in vivo. Nitric oxide-induced cytostasis targets ribonucleotide reductase by rapid and reversible inhibition. However, other studies show there could be other targets that are responsible for producing long-lasting cytostasis in ...
Aminopterin (4-aminopterojska kislina) je 4-amino derivat folne kisline, ki izkazuje imunosupresivno in citostatično delovanje. Aminopterin je sintezni derivat pterina. Deluje kot encimski zaviralec, ker se veže na vezišča encima dihidrofolat reduktaze (namesto fiziološkega substrata - folne kisline) in s tem zavre sintezo tetrahidrofolata. Posledično pride do motenj nastajanja nukleotidov in s tem do zaviranja sinteze DNK, RNK in beljakovin. Aminopterin se je nekoč uporabljal za zdravljenje raka, dandanes pa ga je povsem nadomestil metotreksat, ki je spojina s podobno strukturo. Ponekod se še vedno uporablja kot rodenticid. Leta 2007 se je v ZDA pojavil škandal z aminopterinom, ko so v okoli 100 vrst hrane za pse in mačke dokazali znatne količine spojine (nad 40 ppm). Hrano so umaknili iz prodaje. Aminopteridina pri živih živalih ni mogoče dokazati. Obstajajo sumi na nefrotoksično delovanje (strupen učinek na ledvice), vendar nedvomnih dokazov o njegovem delovanju na zdravje ...
Echocardiographic imaging of the heart with a two-dimensional Echo-machine and Doppler analysis that reveal valve anomalies, blood pressure variations, weakness of the heart muscle, and other pathological conditions. Diagnosis and therapy ...