TS-1, an anticancer, antimetabolis agent, has shown clinically superior antitumor activity against unresectable advanced or recurrent gastric cancer (UARG). A biological response modifier, lentinan (LNT) prolonged the survival period of patients with UARG when combined with tegafur (FT). To assess the efficacy, the safety and prognostic factors of chemo-immunotherapy using TS-1, a FT derivative, and LNT, we conducted a multi-institutional pilot study in patients with UARG. Patients were treated with TS-1 at 80 mg/m2/day (bid) for 4-weeks, and LNT was given at 2 mg/body (i.v.) in a week, followed by a 2-week rest for 4 cycles. Twenty-two patients were entered from 4 institutes and 19 patients were eligible. The median survival time in eligible patients was 400 days. The incidence of hematological toxicity (grade 2 leukopenia), and non-hematological toxicity (grade 3 nausea or fatigue) was 5.3% (1/19) and no grade 4 toxicity was observed. The response ratio was 37.5% in 8 patients who had been
A naturally derived polysaccharide, Beta glucan is a bioactive molecule found in many different substances includes barley, oats, yeast and mushrooms. Because Beta glucan is a long-chain polysaccharide, the different sugars can be linked in several different ways, which allows for different appearances and functions to the different forms of Beta glucan. Therefore, it is important to pay attention to the source of the Beta glucan we use based on the results we are looking for.. The mushroom source of Beta glucan has been used in many countries in Asia for health purposes for a long time. When you look at research on mushroom Beta glucan, a large percentage has been done in Asian laboratories in the past. However, in the United States, researchers from the Sloan-Kettering Institute and City of Hope are catching up with their progress. As the result, Beta glucan extracted from different mushrooms now has trade names used for research and health uses, like Lentinan, D-fraction, AMFM…etc. Having ...
Various mushrooms have been used as folk medicine for long times, the higher Basidiomycetes have become a matter of great interest due to their diverse nutritional, medicinal, and pharmacological properties. 650 species and intraspecific taxa from 182 genera of higher Hetero- and Homo-basidiomycetes have been listed that contain biological active anti-tumor and immunostimulative polysaccharides. Recently, lentinan, shizophyllan and krestin have been accepted as immunoceuticals in several oriental countries. Polysaccharides present the highest capacity for carrying biological information since they have the greatest potential for structural variability. Immunoceutical compound offer hope for cancer patient. These substances are pro-homeostatic uniquely effective immune boosters, which pose no threat of autoimmune backlash. The enhancement or potentiation of host defense mechanisms has been recognized as a possible means of inhibiting tumor growth without harming the host. Antitumor polysaccharides
Nishitani Y, Yamamoto K, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, Mizuno M. Intestinal anti-inflammatory activity of luteolin: role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells. Biofactors. 2013 Sep-Oct;39(5):522-33. doi: 10.1002/biof.1091. PMID 23460110 ...
Common names: Forest mushroom, lentinula, pasania fungus, black mushroom, hua gu. Overview Shiitake, an edible mushroom indigenous to East Asia, is cultivated worldwide for its health benefits. Both the fresh and dried forms of the mushroom are a staple in East Asian cooking. Shiitake is considered a medicinal mushroom based on its use in traditional medicine. It is also valued as an anticancer agent.. Lentinan, a polysaccharide isolated from shiitake, has been well studied and is thought responsible for the mushrooms beneficial effects. An injectable form of lentinan is used for cancer treatment in some countries but has not been evaluated in large clinical trials.. Shiitake is available in most supermarkets, in many restaurants and in Asian grocery stores.. The Science. Lentinan demonstrated anticancer effects in colon cancer cells in vitro,1 which may be due to suppression of cytochrome P450 1A enzymes that metabolize procarcinogens to their active form.2 Lentin, the protein component of ...
It may seem strange, but a powerful type of sugar found in the cell walls of fungi, bacteria, yeasts, algae, and plants may hold the key to boosting your immune system and possibly even helping you fight cancer. Beta glucan is a natural glucose polymer that increases the immune systems defenses by triggering a cascade of events that regulate the immune system to make it more effective. They are known to stimulate macrophages, which are powerful immune cells that attack and destroy pathogens. They also stimulate white blood cells that can take out tumors and viruses.. A study by the US Department of Agricultures Beltsville Human Nutrition Research Center found that beta glucan extract significantly lowered the cholesterol of men and women with mildly high cholesterol. That makes beta glucan an important player in maintaining heart health. Japanese researchers at Teikyo Universitys Biotechnology Research Center have also demonstrated that lentinan, a type of beta glucan has anti-tumor ...
Each capsule supplies: Shiitake Mushroom Powder (aerial part) . . . . . . . . . . . . . . . . . . 500 mg RECOMMENDATION: One (1) to four (4) capsules between meals as a dietary supplement or as oterwise directed by a healthcare professional. Contains: 90 CapsulesShiitake Mushroom - supplies Shiitake Mushroom powder, which contains beta-glucan, a polysaccharide lentinan believed to be responsible for its immuno-modulating properties. Consider for dietary support for healthy immune function.
One of the main applications of this mushroom is its ability to assist in the treatment of cancer. Japanese cancer patients use a combination of maitake, shiitake and reishi to increase our defenses. In this way, they can reduce the doses of chemicals in the treatment with chemotherapy while they protect our cells from damage caused by this treatment.. It has been observed that the negative symptoms of chemotherapy such as vomiting, nausea or physical exhaustion decrease after taking these preparations.. This property is mainly due to the action exerted by the lentinan polysaccharide Beta-D-glucan on the immune system. This complex carbonate has the ability to raise the level of interferon, a protein that inhibits the growth of viruses and tumors, while encourages action of macrophages, T cells and NK cells. Thus, the defense system is mostly able to distinguish those foreign elements, virus-infected cells or tumor cells and destroy them before they cause tumors or possible diseases.. Recent ...
Tumor Necrosis Factor(TNF-α) is a cytokine, substances secreted by certain cells of the immune system that have an effect on other cells. This is indeed helpful in fighting abnormal turmor cells in body. Research done on ripening bananas has proved that the levels of TNF-α induction increased markedly with dark spots on skin before the entire banana peel turned brown. The research concluded that the activity of banana was comparable to that of Lentinan, a chemical immunostimulant that is intravenously administered as an anti-cancer agent. So, ripe banana can act as an anti-cancer agent by stimulating the production of white blood cells in the human cell line ...
Qualitative and quantitative colorimetric tests and man-ometric determinations have been used to detect and measure enzyme activity. Because PPOs use molecular
A glucan molecule is a polysaccharide of D-glucose monomers, linked by glycosidic bonds. Many beta-glucans are medically important. They represent a drug target for antifungal medications of the echinocandin class. The following are glucans: (The α- and β- and numbers clarify the type of O-glycosidic bond.) dextran, α-1,6-glucan with α-1,3-branches floridean starch, α-1,4- and α-1,6-glucan glycogen, α-1,4- and α-1,6-glucan pullulan, α-1,4- and α-1,6-glucan starch, a mixture of amylose and amylopectin, both α-1,4- and α-1,6-glucans cellulose, β-1,4-glucan chrysolaminarin, β-1,3-glucan curdlan, β-1,3-glucan laminarin, β-1,3- and β-1,6-glucan lentinan, a strictly purified β-1,6:β-1,3-glucan from Lentinus edodes lichenin, β-1,3- and β-1,4-glucan oat beta-glucan, β-1,3- and β-1,4-glucan pleuran, β-1,3- and β-1,6-glucan isolated from Pleurotus ostreatus zymosan, β-1,3-glucan Properties of glucans include resistance to oral acids/enzyme and water insolubility. Glucans ...
Agaricus blazei extract from Changsha World-Way Biotech Inc.. Search High Quality Agaricus blazei extract Manufacturing and Exporting supplier on Alibaba.com.
Integratore alimentare a base di Agaricus Blazei Murril (ABM) da agricoltura biologica (IT BIO 006) - Made in Europe. Proprietà. A base di Agaricus blazei Murril, Micotherapy ABM risulta utile nel favorire le naturali difese dellorganismo.. Originario della regione montagnosa di Piedade, in Brasile, lAgaricus Blazei Murril (ABM) fu scoperto durante una ricerca epidemiologica nella quale venne riportata la bassa incidenza di malattie degenerative e un aumento della longevità tra gli abitanti di questa regione, che consumavano regolarmente il fungo, rispetto a quelli delle regioni circostanti.. LABM contiene proteine (38,5%), polisaccaridi, glicoproteine, triterpeni, ergosteroli ed altri metaboliti secondari, inoltre è ricco di minerali (calcio, sodio, ferro, potassio, fosforo, magnesio, zinco, rame, manganese e selenio), vitamine del gruppo B (B1, B2, B6, B12) e precursori della vitamina D (ergosteroli). Contiene inoltre elevate quantità di beta-glucani e glicoproteine, modulatori di ...
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Agaricus Blazei Extract appears as a fine brown powder with characteristic taste and odor profiles. This product is often used as an anti-tumor, anti-ca...
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An important aspect of effective stress management is the ability to identify ones own reactions to stress. How one person reacts to stress in may be totally different from someone else. Listed below are common symptoms of stress.. ...
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