Description: Goniodysgenesis (GG) is caused by abnormal development of the anterior chamber of the eye. Due to abnormal development of intraocular fluid egress channels inside the eye the iridocorneal angle (ICA), through which the excessive chamber fluid is filtered and drained. Within dog, population goniodysgenesis is considered as a congenital disease, which can often cause glaucoma or blindness. For first was GG detected in Border Collies in the late 90s in Australia, after that it spread to Europe and USA.. Goniodysgenesis has two forms: severe and mild. The severe form of this disease is caused by the mutation in the gene encoding for olfactomedin-like 3 (OLFML3). This encoded protein facilitates protein-protein interactions, cell adhesion, and intracellular interactions and has a general supporting function. It seems that the mild form of the disease is not associated with this mutation and can be caused by other genetic predispositions. GG is caused by a missense mutation c.590G,A ...

We report a 12-year-old boy with a rare condition consisting of familial bilateral anterior lentiplane (a flat anterior lens capsule) posterior lenticonus, and microcornea. Copyright © 2014 American Association for Pediatric Ophthalmology and

Presented for a routine clearance exam, this dog was bilaterally affected. Water clefts can be seen in the equatorial cortex at the pupil margin (white arrow). The irregular circle seen by retroillumination (black arrow) represents the portion of the capsule and cortex protruding into the vitreous.. ...

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Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC. In cataractous ALCs, patient age, total LM, LMα4, TGF-β1, were all positively correlated with p53. In lens epithelial cell (HLE B-3) senescence models, matrix metalloproteinase-9 (MMP-9) alleviated senescence by decreasing the expression of total LM and LMα4; TGF-β1 induced senescence by increasing the expression of total LM and LMα4. Furthermore, MMP-9 silencing increased p-p38 and LMα4 expression; anti-LMα4 globular domain antibody alleviated senescence by decreasing the expression of p-p38 and LMα4; pharmacological inhibition of p38 MAPK signaling alleviated senescence by decreasing the expression of LMα4. Finally, in cataractous ALCs, positive correlations were found between LMα4 and total LM, as well as

PSEUDOEXFOLIATION GLAUCOMA - Pseudoexfoliation occurs primarily in patients of Scandinavian descent. It is a flaky material that exists on the anterior lens capsule and can also flake

Alport Syndrome. In 1927, A. Cecil Alport first described a syndrome associated with hearing loss also marked by hematuria. The syndrome has a prevalence of 1 in 5000, with 85% of patients having the X-linked form. Non-congenital, sensorineural deafness very frequently, though not always, accompanies the nephropathy of Alport syndrome. The severity of renal disease varies with regard to the type of Alport syndrome and the sex of the individual. It should be noted that patients with this syndrome are also at increased risk for hypertension.. In addition to hearing impairment and renal disease, a variety of ocular lesions and defects are common in patients with Alport syndrome, including anterior lenticonus (congenital condition of the lens in which the surface is conical), progressive distortion of the lens, and pigmentary changes. In fact, the presence of anterior lenticonus is strongly suggestive of a diagnosis of Alport syndrome. CHARGE Association. The CHARGE acronym stands for coloboma of ...

Pseudoexfoliation syndrome, often abbreviated as PEX and sometimes as PES or PXS, is an aging-related systemic disease manifesting itself primarily in the eyes which is characterized by the accumulation of microscopic granular amyloid-like protein fibers. Its cause is unknown, although there is speculation that there may be a genetic basis. It is more prevalent in women than men, and in persons past the age of seventy. Its prevalence in different human populations varies; for example, it is prevalent in Scandinavia. The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a buildup of pressure leading to glaucoma and loss of vision (pseudoexfoliation glaucoma, exfoliation glaucoma). As worldwide populations become older because of shifts in demography, PEX may become a matter of greater concern. Patients may have no specific symptoms. In some cases, patients may complain of lessened visual acuity or changes in their perceived ...

In three eyes which underwent cataract extraction no evidence of senile pseudoexfoliation was found either before, or immediately after, surgery in spite of repeated biomicroscopical examination under full mydriasis. Years later pseudoexfoliative material was found on the anterior hyaloid and on the pupillary border. In another case, wherein the lens was traumatically dislocated and had lain in the inferior vitreous chamber for 53 years, pseudoexfoliative material was present on the anterior hyaloid, but not in the vitreous. Collating these clinical observations with data from electron and light microscopy studies, the authors refute the assumption that lens epithelium is the source of pseudoexfoliative material. ...

In myopic eyes and post-vitrectomy eyes, we can get an overly deep anterior chamber during cataract surgery. The infusion pressure from the phaco probe or I/A probe will push the iris against the anterior lens capsule and create a seal. Now that there is less pressure in the vitreous cavity and posterior chamber, this causes…

The scleral pigment, best seen temporal, is found in all affected individual in this bilateral disease. The dark iris is not visible due to the dilated pupil. Pigment can be seen on the anterior lens capsule (black arrows). The pigment and scar on the axial cornea is due to exposure keratitis secondary to buphthalmia. Intraocular pressure at this time was 22mmHg.. ...

Alport syndrome is an X-linked recessive disease characterised by: haematuria sensory neural hearing loss: typically high frequency 2 ocular abnormalities anterior lenticonus: most common ocular abnormality; may result in cataracts perimac...

Purpose: The purpose of this study was to investigate the expected laser plasma characteristics across the anterior lens and aqueous boundaries.. Methods: A laser plasma model was developed that describes the evolution of plasma developed from focusing a short pulse laser. This model included plasma shielding characteristics in the description of the plasma evolution. The model characteristics in water where compared the moving breakdown model to validate performance. The model was then applied to the anterior boundary between the lens and the anterior chamber where the characteristics of the boundary was described by using an energy level model to represent the different constituents of the boundary. The aqueous, capsule, and fibrous mass were modeled having a binding energy of 6.5eV, 7.5eV, and 6.8eV respectively. The focal position of the laser pulse in an F/4 system relative to the boundary was then analyzed to determine the characteristics of the laser interaction across the boundary. The ...

Exfoliation: Does It Really Do a Body Good?Exfoliation is a practice that beauty buffs and dermatologists the world over deem essential to a good skin care regime. The process involves removing dead skin cells that sit on the skins top layer (the epidermis) to reveal softer, smoother skin below. Results of exfoliation

Pseudoexfoliation is an ocular condition in which a fibrillar, proteinaceous substance is produced in abnormally high concentrations. The shedding of the material can make structures within the eye less resilient. Studies suggest pseudoexfoliation to be 0.6 percent in 52- to 64-year-olds rising to 5 percent in 75- to 85-year-olds. Pseudoexfoliation is routinely identified during a. ...

Youtubers have been raving face shaving for a while now so, today the Dermaflash Facial Exfoliation Device caught my eye on QVC.com and I was all like, I

In the conceptualization and planning stages of this feature we were certain it was going to be among the best coverage we have offered in regards to exfoliation. Indeed I think the information in this feature as well as the supporting articles is very informative and well written. What I know now that I didnt know before we began the process of talking to potential writers, is how difficult it would be to find four people who were willing to contribute to this feature, primarily because of the title. I can only imagine what they would have said if they had seen the cover and opening art for this feature. Their reaction might have been similar to your own and even ours when we first looked at these images - a bit shocked and taken aback. But lets stay focused, and I will get back to the art in a minute. ...

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The patient presents with a fine, flaky material on the anterior lens capsule at the pupillary margin. Over time, this coalesces into a characteristic bulls-eye pattern seen in pseudoexfoliation. There is often increased transillumination of the iris at the pupillary margin and there may be pigment granules on the endothelium and iris surface. Within the angle, there may be observable pigment or clear flaky material. Initially, intraocular pressure is unaffected; however, elevated IOP develops in up to 80 percent of patients. In these cases, glaucomatous cupping and visual field loss may ensue ...

Purpose: To determine the qualitative change in stress on the lens capsule during in vivo human accommodation. Methods: Nine subjects [mean age: 30 years, range: 25-38 years] were studied, each of whom had undergone a phakic refractive intraocular lens (PRL) surgical procedure. The change, during accommodation, of stress on the surface of the anterior lens capsule (ALS) was determined by employing high-resolution anterior segment optical coherence tomography (OCT). This was done by comparing the ratio of the intensity of the image from the anterior surface of the natural lens (ALS) to the images of the anterior corneal surface (ACS), posterior corneal surface (PCS), and the posterior surface of the phakic refractive intraocular lens (PPRLS) before and during accommodation. Results: The intensities of the OCT images of the ACS and PPRLS did not significantly change during accommodation when compared to their respective baselines, while the intensity ratios: ALS/ACS, ALS/PCS and ALS/PPRLS all ...

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.. And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing. ...

Ocular lens tissue mechanics: Understanding the mechanics of lens accommodation (ability of the eye dynamically to focus near to far, or far to near) can assist in the diagnosis of early presbyopia as well as in the development of new potential clinical treatments and intraocular lens (IOL) design and implantation strategies. Related to the mechanism of focusing, presbyopia is an ocular disease that stems from age-related loss of lens accommodation leading to loss of focusing range and near vision. This is attributed to changes in ciliary muscle function, as well as changes in the elastic and deformable properties of the lens substance and the lens capsule. The precise relationship of these changes, however, is not well described. During cataract surgery, the process of removing a circular portion latitudinally of the anterior lens capsule can lead to tearing of the capsule longitudinally, propagating to the posterior capsule and loss of the full lens and zonules. A fundamental understanding of ...

Read Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long-term stability of the capsular bag after cataract surgery, Graefe

Purpose: Exfoliation syndrome (XFS) is an age-related disease, manifesting primarily in the eyes. XFS is a very common and recognizable cause of secondary glaucoma world-wide. We sought to better understand the overall disease process of XFS. To this end, we thus conducted a genome-wide association study (GWAS) on ~1500 patients with XFS matched to ~1200 controls from Japan.. Methods: Genome-wide genotyping was performed using the Illumina OmniExpress beadchip, which assesses ,700,000 single nucleotide polymorphisms (SNPs) throughout the human genome. The association between each genetic marker and susceptibility to XFS was measured using logistic regression, contrasting each SNP genotype between XFS patients and controls. The analysis was performed with additional compensation for the top 6 principal components of genetic stratification. We followed up the most significantly associated genetic markers (surpassing P , 1 x 10-4 on primary association analysis) on a further ~7,000 patients and ...

An eye with pseudoexfoliation showing the dandruff like pseudoexfoliation material on the surface of the cataractous lens capsule.

Choroidal ruptures are breaks in the choroid, the Bruch membrane, and the retinal pigment epithelium (RPE) that result from blunt ocular trauma (the most common eye injury). Choroidal rupture can be secondary to indirect or direct trauma.

Pseudoexfoliation is an ocular condition in which a fibrillar, proteinaceous substance is produced in abnormally high concentrations. The shedding of the material can make structures within the eye less resilient. Studies suggest pseudoexfoliation to be 0.6 percent in 52- to 64-year-olds rising to 5 percent in 75- to 85-year-olds. Pseudoexfoliation is routinely identified during a. ...

Is Skin Exfoliation a common side effect of Tildiem? View Skin Exfoliation Tildiem side effect risks. Female, 60 years of age, was diagnosed with lung abscess and took Tildiem 60 Mg Qd Po. Patient was hospitalized.

Posted on October 03, 2015 by Melanie Brown Exfoliation is the removal of dead skin cells on the skin surface. This can be quite simply removed with a good facial scrub. If the dead skin is not removed, the underlying skin is not as healthy as it should be.. Exfoliation is particularly important as we get older because our cell regeneration slows down. The body is slow at shedding skin cells whilst it is attempting to generate new ones.. When old skin cells start to pile up on the surface of the skin it can leave the skin looking dull, rough and dry. This build up can lead to excess oil and clogged pores resulting in acne and blemishes.. Exfoliation helps the skin pores to open up. This means that moisturising products can penetrate more deeply into the skin which in turn means that the product is more effective in hydrating the skin.. If you want to have radiant glowing skin, exfoliate two to three times a week. If exfoliation is done in excess of the suggested times, it can result in the skin ...

Exfoliation delivers a tighter, firmer, smoother look and feel of skin. Because of this result, many fall into the trap of over-exfoliation: an over-zealous approach that can actually reduce skins vitality and make it more susceptible to damage from UV light.Over-exfoliation triggers the inflammatory response, leading

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Looking at the slice of skin above , one could be tempted to think new skin cells start from the bottom and travel through all the layers to the top before they are shed, but thats not how it works. In general, each layer of the skin does its own thing when it comes to cell development ...

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Mike Quinseys Higher Self Message, May 17, 2019 This extract is based on historical facts and information from Kryon. It is most informative about a period that had a great bearing upon our present time, and enables us to place events in their proper order so that they are historically correct. Going back further completes … Continue reading Many of your souls are very old and wise, and youve been here a long time. →

Have any of you experienced GI bleed with your very old? MIL had a heavy bleed yesterday. We have been in the hospital since. There has been no action until just a few minutes ago. The look on the nurses face was different with the second round. I will be talking with the GI doc shortly, however, I was wondering if anyone else has experienced this? I am very reluctant to do any type of procedures. She is already in decline, dementia, weak. But I need to hear some of the thought process from someone who has walked this path before. Thanks in advance for sharing your experience ...

Cataract surgery in patients with pseudoexfoliation syndrome: current updates Luigi Fontana, Marco Coassin, Alfonso Iovieno, Antonio Moramarco, Luca Cimino Ophthalmology Unit, Arcispedale Santa Maria Nuova – IRCCS, Reggio Emilia, Italy Abstract: Pseudoexfoliation is a ubiquitous syndrome of multifactorial origin affecting elderly people by increasing the risk of cataract and secondary glaucoma development. Despite modern techniques and technologies for cataract surgery, pseudoexfoliation syndrome represents a challenge for surgeons because of the increased weakness of the zonular apparatus and limited pupil dilation. Due to the inherent difficulties during surgery, the risk of vitreous loss in these patients is several times higher than in cataract patients without pseudoexfoliation. Using currently available surgical devices (ophthalmic viscosurgical device, iris retractors and ring dilators, capsular tension ring, etc.), the risk of intraoperative complications may be much reduced, allowing

Purpose: To evaluate plasma total homocysteine (tHcy) and nitric oxide (NO) marker levels in patients with pseudoexfoliation syndrome (PXS), pseudoexfoliation glaucoma (PXG), primary open-angle glaucoma (POAG), and normal controls. Methods: This cross-sectional, prospective study involved 19 patients with POAG, 18 with PXS, 22 with PXG, and 20 control subjects. Fasting tHcy levels of all study participants were determined using a fluorescence polarization immunoassay method. Quantitation of total nitrate was based on the Griess reaction, in which a chromophore with a strong absorbance at 545 nm is formed by reaction of nitrite with a mixture of naphthylethylenediamine and sulphanilamide. Results: The mean plasma homocysteine level was statistically significantly elevated in the PXS (p=0.033) and the PXG (p=0.023) groups but not in the POAG group (p=0.996) when compared with the control group. Multiple logistic regression analyses comparing the various patient groups with the single control group ...

P.G.C. Bedford BVetMed PhD DVOphthal DipECVO FRCVS. You should have no doubts about the fact that the type of Primary Glaucoma which occurs in the English Springer Spaniel is the most devastating eye disease the middle-aged dog could suffer. It is known as angle closure glaucoma and it is characterised by sudden onset blindness and pain, both of which prove so very difficult to treat that a life without sight is the usual prognosis for the patient. Such is the pain and the damage to the eye that the removal of the eye may prove necessary in many instances. It is a disease to be avoided at all costs, but sadly the type of inheritance involved is unknown. This always renders breeding advice difficult, for such advice cannot be specific enough for ease of selection of the right genotype and will make the future development of a DNA based test really difficult. Fortunately, although not 100% reliable, a relatively simple clinical diagnostic test is available to give guidance in breeding programmes. ...

OCT Application Before and After Cataract Surgery. By Xiaogang Wang, Jing Dong, Suhua Zhang and Bin Sun. Optical coherence tomography (OCT), especially anterior segment OCT (AS-OCT), plays an important role in ophthalmology. With the technology evolving from time-domain to spectral-domain, more and more detailed ocular information has become available. Anterior segment OCT provides particularly useful information for cataract surgeons. This chapter focuses mainly on AS-OCT evaluation of eyes before and after cataract surgery. Four aspects including: (1) anterior lens capsule and lens epithelium evaluation using spectral-domain OCT (SD-OCT); (2) investigation of clear corneal incision in femtosecond laser assisted cataract surgery using SD-OCT; (3) capsular block syndrome evaluation before and after treatment using SD-OCT; (4) IOL power calculation in post-myopic excimer laser eyes using SD-OCT, will be discussed in this chapter.. Part of the book: OCT ...

The developing lens is a powerful system for the study of tissue interactions and also the target of the medically important ocular disease cataract, a lens opacity that affects over 25 million individuals and is the leading cause of blindness worldwide (Asbell et al., 2005; Hejtmancik, 2008). The mature lens consists of two polarized cell types: a monolayer of lens epithelial (LE) cells and a mass of elongated and aligned lens fiber (LF) cells. The entire structure is covered by a lens capsule, a thick basement membrane secreted by LE and early LF cells in a polarized manner (Wederell and de longh, 2006). During development, the lens originates from a thickening of the head ectoderm that invaginates to form the lens pit, and then detaches to form the lens vesicle. Cells from the anterior lens vesicle differentiate into epithelial cells, while cells from the posterior lens vesicle elongate to form primary fiber cells. In later embryogenesis, LE cells continuously proliferate and differentiate ...

TY - JOUR. T1 - Traumatic corneal laceration with associated lens capsule disruption. T2 - A retrospective study of 77 clinical cases from 1999 to 2009. AU - Paulsen, Michael E.. AU - Kass, Philip H. PY - 2012/11. Y1 - 2012/11. N2 - Objective Examine prognostic factors that may indicate when surgical lens removal is indicated to prevent vision-threatening complications in patients presented following traumatic perforating corneal laceration with associated lens capsule disruption. Procedures Seventy-seven patients (10 cats and 67 dogs) were evaluated with this injury; of these, 47 were presented acutely and treated surgically and/or medically. Successful outcome was defined as functional vision in the treated eye. Results The 47 patients with acute injuries were divided into 3 treatment groups A-C for comparison; A - corneal repair/lens removal (n = 15), B - corneal repair/no lens removal (n = 9), C - medical management (n = 23). Groups A and B showed a significantly greater rate of vision loss ...

Dear Tom,. Chances are the rim is very much there.. We see this every so often and the medical term is synechia or adhesion of 2 closely approximated skin surfaces secondary to chronic irritation. This conceivably could be treated with some local anesthesia and separating the 2 surfaces and then applying an ointment. You would continue your synechia treatment at least daily until skin replaces the raw area. Without a circumcision you still would be left with phimosis, but you could opt to treat on an elective basis whenever you are ready.. Hoping this is of help.. Please check out our other blog posts about Penile Synechia.. Harold M. Reed, M.D. ...

The Glaucoma Genetics Lab joined Tin Aung, CC Khor, and our colleagues around the world in conducting a genome-wide association study (GWAS) of exfoliation syndrome and glaucoma. This huge multi-center study of 13,620 patients and 109,837 control subjects identified five new genetic risk factors for exfoliation syndrome: POMP, TMEM136, AGPAT1, RBMS3, and SEMA6A. Read more about this discovery here (11.8 MB).. ...

The most effective approach to practical exploitation of the layered solids that often have unique valuable properties-such as graphene, clays, and other compounds-is by dispersion into colloidal suspensions of monolayers, called liquid exfoliation. This fundamentally expected behavior can be used to deposit monolayers on supports or to reassemble into hierarchical materials to produce, by design, catalysts, nanodevices, films, drug delivery systems, and other products. Zeolites have been known as extraordinary catalysts and sorbents with three-dimensional structures but emerged as an unexpected new class of layered solids contributing previously unknown valuable features: catalytically active layers with pores inside or across. The self-evident question of layered zeolite exfoliation has remained unresolved for three decades. Here, we report the first direct exfoliation of zeolites into suspension of monolayers as proof of the concept, which enables diverse applications including membranes and ...

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Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material ...

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The following signs were each graded on a 0 - 3 scale (0 = absent; 1 = mild; 2 = moderate; 3 = severe): posterior synechia, hypopyon, limbal injection, and keratic precipitates. Peripheral synechia was graded by the combined number of clock hours affected (0 = absent; 1 = , 3 hrs; 2 = 3-6 hours; 3 = , 6 hours). The total sign score was calculated as the sum of the 5 individual sign scores, the anterior chamber cell grade and the anterior chamber flare grade. The minimum/best total sign score was 0, and the maximum/worst total sign score was 23 ...

Scalp exfoliation has great benefits for your hair. Learn about the benefits of scalp exfoliation and how you can make it a part of your hair care routine.

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The MH Salon offers a variety of exfoliation treatments that result in a more youthful appearance by removing dull surface cells and revealing the firmer, healthy new skin beneath. ...

Dermaplaning is a form of manual exfoliation performed primarily on the face by a well trained and licensed medical aesthetician with special tools.

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Lack of constituency development is being identified as a contributing factor to the current issue of cross-border registration.. Chair of the Parliamentary Public Accounts Committee and Member of Parliament for East Honiara, Douglas Ete reveals in Parliament yesterday morning.. Parliament briefly resumed yesterday and was further adjourned to October 31.. Contributing to the Motion of Adjournment, Mr Ete says people are moving to register in different constituencies due to lack of development from their. Member of Parliament.. He revealed, a total of twenty-six million dollars has not been used by MPs last year due to lack of fund retirements.. Thats basically one of the reasons, there are many reasons but this is one of the reasons. Youll notice that one or two Members of Parliament were featured in. the papers with people saying they are complaining about certain intending candidates doing such and such but twenty-six million dollars was not used by. Members of Parliament last year because ...

Dendritic cells (DC), the most potent professional antigen-presenting cells, hold promise for improving the immunotherapy of cancer. In this study, we investigated the ability of normal donor DC pulsed ex vivo with 12 mer PML-RAR alpha (A) peptide (SGAGEAAIETQS) to generate peptide specific autolo …

Abstract The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved physical properties studies (weight variation, thickness, length, width, hardness, friability, and drug content) of tablets and in vitro release kinetics assessment. The USP paddle method was operated at 50 rpm selected to perform the dissolution test and 900 ml phosphate buffer of pH 7.4 was used as dissolution medium. The drug release from each formulation was analyzed by using release kinetics theories. All formulations followed Higuchi release kinetics. When the release data was plotted into Korsemeyer-Peppas equation, then it was confirmed that F-1 to F-5 exhibited fickian type drug release ...