Breast metastasis from extra-mammary malignancy is rare, constituting 2% of breast tumors. Uterine leiomyosarcoma is a rare soft tissue neoplasm comprising 1% of all uterine malignancies. This report presents the first case of uterine leiomyosarcoma metastasis of the breast. A 44-year-old woman, G4P3AA1, presented with a one-week history of painless bilateral breast lumps. Twelve years previously she had undergone a right salpingo-oophorectomy and hysterectomy for uterine leiomyosarcoma. An excisional biopsy of the breast nodule was performed, and the histopathological study revealed the nodule was composed of spindle cells, typical of breast metastasis with uterine leiomyosarcoma found in the immunohistochemical study. The patient was healthy and symptom free during the 12 month post-operative follow-up period.
TY - JOUR. T1 - Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma. T2 - Morphological significance of calponin h1. AU - Hayashi, Takuma. AU - Horiuchi, Akiko. AU - Sano, Kenji. AU - Hiraoka, Nobuyoshi. AU - Kasai, Mari. AU - Ichimura, Tomoyuki. AU - Sudo, Tamotsu. AU - Nishimura, Ryuichiro. AU - Ishiko, Osamu. AU - Shiozawa, Tanri. AU - Kanai, Yae. AU - Yaegashi, Nobuo. AU - Aburatani, Hiroyuki. AU - Konishi, Ikuo. PY - 2012/6/21. Y1 - 2012/6/21. N2 - Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that ...
Soft tissue sarcoma of the intra-abdominal organ is a rare malignant tumor and leiomyosarcoma is its most common histologic type [3]. Regardless of the histologic type, however, surgical resection is considered standard therapy [1]. There have been few studies of distant metastases that occur after the complete resection of a primary leiomyosarcoma. There is no generally accepted treatment for this either, especially for a liver metastasis, although surgery remains the mainstay, because leiomyosarcoma is relatively chemoresistant and radioresistant [4]. There have been few case reports of primary or metastatic leiomyosarcoma of liver [5]. Faraj et al. [4] reported five cases of liver resection for metastatic colorectal leiomyosarcoma, with a median survival of 47 months. Akwari et al. [6] reported 108 cases of intestinal leiomyosarcoma, but with no mention of the management of these metastases. McGrath et al. [7] analyzed 51 cases of primary gastrointestinal sarcoma (virtually all were ...
TY - JOUR. T1 - Tumor immunoediting, from T cell-mediated immune surveillance to tumor-escape of uterine leiomyosarcoma. AU - Hayashi, Takuma. AU - Horiuchi, Akiko. AU - Sano, Kenji. AU - Hiraoka, Nobuyoshi. AU - Ichimura, Tomoyuki. AU - Ishiko, Osamu. AU - Kanai, Yae. AU - Yaegashi, Nobuo. AU - Aburatani, Hiroyuki. AU - Shiozawa, Tanri. AU - Tonegawa, Susumu. AU - Konishi, Ikuo. PY - 2013. Y1 - 2013. N2 - The majority of smooth muscle tumors found in the uterus are benign, but uterine leiomyosarcomas (LMSs) are extremely malignant, with high rates of recurrence and metastasis. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not clearly understood. The presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules is important for tumor rejection by cytotoxic T-lymphocytes (CTLs). Such antigenic ...
A 59-year-old woman, diagnosed 7 years ago with uterine leiomyosarcoma (ULMS), developed several intrathoracic, pelvic and lately intra-abdominal and brain metastases. On each occasion, surgical resection was followed by a course of failed chemotherapy. Lately she presented with acute neurological deterioration and focal signs. Magnetic resonance imaging demonstrated two presumed brain parenchymal lesions involving the supratentorial and infratentorial compartments. She underwent surgical resection of the left cerebellar lesion. Histological analysis of the brain specimen confirmed the presence of metastatic ULMS. Leiomyosarcoma of the uterus is an uncommon tumor with a very aggressive course and poor prognosis. Multiple organ metastases from ULMS are an extremely rare condition, and prognostically alarming despite current treatments ...
This is a pilot study of adjuvant therapy for patients with leiomyosarcoma of the uterus that has been completely removed by surgery. Adjuvant therapy means that the tumor (the leiomyosarcoma) has been completely removed by surgery; thus, giving further treatment now is done in hopes of decreasing the chance that the tumor will come back (relapse or recur). The main goal of this study is to show that this series of treatments is safe for patients with your type of tumor.. In this trial you will be getting drugs that have been approved for use in some types of cancer. In this study we wish to see whether the combination of two chemotherapy drugs, docetaxel and gemcitabine can decrease the chance of your tumor, leiomyosarcoma of the uterus, from coming back (relapsing). We will also be looking at the short-term side effects and risks of the drugs given in this combination to patients with leiomyosarcoma that has been completely resected (removed by surgery).. The combination of gemcitabine and ...
Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international literature, radiation-induced sarcoma arise in 0.035 to 0.2 % of all irradiated patients. Especially in the head and neck region, radiation-induced leiomyosarcoma is an extremely rare lesion. The authors report a case of a radiation-induced leiomyosarcoma of the tonsillar region of the oropharynx in a 51-year-old male patient, who had undergone radiation therapy of this region 38 years before. The lesion was treated by radical surgery. Diagnostic steps, histological presentation and therapy are described in detail and the literature concerning radiation induced malignancies in general as well as radiation induced leiomyosarcoma in particular is reviewed. The highlights of this case are an extremely uncommon location and a rare pathological entity of radiation induced malignancies.
Leiomyosarcoma: Find the most comprehensive real-world symptom and treatment data on leiomyosarcoma at PatientsLikeMe. 41 patients with leiomyosarcoma experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Chemotherapy to treat their leiomyosarcoma and its symptoms.
PRIMARY OBJECTIVES:. I. To evaluate the objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 of patients with advanced leiomyosarcoma of the uterus (ULMS) treated with nivolumab.. II. To evaluate the objective response rate per RECIST 1.1 of patients with advanced ULMS treated with nivolumab in combination with ipilimumab.. SECONDARY OBJECTIVES:. I. To evaluate the toxicity of nivolumab in patients with advanced ULMS. II. To evaluate the toxicity of nivolumab in combination with ipilimumab in patients with advanced ULMS.. III. To evaluate the progression-free survival of ULMS treated with nivolumab. IV. To evaluate the progression-free survival of ULMS treated with nivolumab in combination with ipilimumab.. V. To explore the relationship between PDL1, PD1 in infiltrating lymphocytes and PD2 status in archival tumor, and pre/post treatment biopsies in a minimum of 10 patients.. TERTIARY OBJECTIVES:. I. To explore the relationship between general immune response ...
Leiomyosarcoma of the Small Intestine (Intestine Small Leiomyosarcoma): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
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Do You Have Leiomyosarcoma? Join friendly people sharing true stories in the I Have Leiomyosarcoma group. Find support forums, advice and chat with groups who share this life experience. A Leiomyosarcoma anonymous support group with information on di...
Discussing the premise of the study, lead investigator Frédéric Amant (Leuven Cancer Institute, Belgium) commented: "We wanted to generate a clear view on the presence of targetable proteins in all subtypes of uterine sarcomas, with the aim of improving treatment options for these patients. Identifying biomarkers is crucial because novel treatments are expensive, underscoring the importance of patient selection.". The investigating team assessed five proteins in 288 samples of uterine sarcoma. In terms of subtypes, these samples included 157 leiomyosarcomas, 52 benign uterine stromal tumors and 41 normal uterine tissues. The remaining samples consisted of endometrial sarcomas, adenosarcomas and other undifferentiated types of uterine sarcoma.. These analyses uncovered that activated P-S6S240 is more often found expressed in high-grade tumors when compared with low-grade tumors - 32% vs 9%, respectively. Given that P-S6S240 is involved in the PI3K/mTOR cell signaling pathway, the team went on ...
Inferior vena cava leiomyosarcoma is a rare tumor with a variety of symptoms. A 41-year-old woman was admitted with nonspecific epigastric pain. Computed tomography revealed a dense mass between the inferior vena cava and the liver. The patient underwent successful resection of the mass. The pathologic study confirmed leiomyosarcoma. Adjuvant radiation therapy was completed, and after 12 months of follow-up, the patient had no problems. © 2014 SAGE Publications.. ...
Leiomyosarcoma of the inferior vena cava is a rare tumour arising from the smooth muscle fibres of the media with a mean size at diagnosis generally around 12 cm (range 2-38 cm). This study compares a 4-cm leiomyosarcoma of the inferior vena cava dis
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The goal of this clinical research study is learn if taking Femara (letrozole) after a hysterectomy (surgical removal of the uterus) for uterine leiomyo
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Lawsuit information regarding Leiomyosarcoma caused by power morcellator. Learn more to see if you qualify for a morcellator Leiomyosarcoma lawsuit.
Paratesticular leiomyosarcomas are rare and can lead to significant morbidity and mortality, if inadequately diagnosed or treated. We present a case of paratesticular leiomyosarcoma in an 88-year-old man presenting with a left scrotal mass with ultra
Images intestinal epithelioid leiomyosarcoma / jejunum https://twitter.com/dusk2don/status/967330551651819520 See also intestinal tumors (...)
Uterine sarcoma is a rare tumor of mesodermal origin, accounting for 2-6% of uterine malignancies. Leiomyosarcoma (LMS) has been reported in only 1% of all uterine malignancies and is regarded as the most common primary uterine sarcoma. Herein, we present a case of LMS with unusual macroscopic features. The patient was a 61-year-old woman with LMS, which consisted of a large cystic mass (88×136 mm), containing six liters of brownish fluid on the right side of the pelvis and abdomen. The fundus of the uterus was ruptured by the solid part of the tumor. For treatment, total hysterectomy, salpingo-oophorectomy and the optimal resection of tumoral parts were carried out. Overall, the distinctive biological behavior and poor overall survival of uterine sarcoma challenge the post-operative management of this tumor. According to the one-year follow-up, the patient was disease-free. Unfortunately, no further information is at hand beyond this period.
In situ hybridization showed EBV genomes in all muscle cells of the five leiomyosarcomas and the two leiomyomas from the six HIV-infected children. Quantitative PCR demonstrated strikingly high levels of EBV in tumor tissue, with as many as 4.3 genome copies per cell. Two colonic leiomyosarcomas obtained from different sites at different times from one patient contained different episomal EBV clones, signifying the presence of distinct monoclonal EBV-related tumors. We found biclonal EBV infection in the leiomyosarcoma of another patient. No EBV was detected in normal muscle or tumor specimens from HIV-negative patients. Immunostaining for the EBV receptor was strongly positive in six of the seven leiomyomas and leiomyosarcomas from the patients with AIDS. Conclusions: ...
http://library.med.utah.edu/WebPath/jpeg4/FEM032.jpg Here is the microscopic appearance of a leiomyosarcoma. It is much more cellular and the cells have much more pleomorphism and hyperchromatism than the benign leiomyoma. An irregular mitosis is seen in the center. http://library.med.utah.edu/WebPath/jpeg4/FEM033.jpg As with sarcomas in general, leiomyosarcomas have spindle cells. Several mitoses are seen here, just in this one high power field.
Leiomyosarcoma (LMS) is an uncommon tumor among the spectrum of soft tissue sarcomas. It is exceedingly rare in the head and neck regions. We report a case of laryngeal LMS that presented with obstructive symptoms, which was amenable to conservative surgery and postoperative irradiation. There is no …
Shortly after the operation, Dr Reed learned that she had a uterine leiomyosarcoma and that morcellation had advanced it to stage IV. She underwent cytoreduction and hypothermic intraperiotoneal chemotherapy followed by six rounds of systemic chemotherapy. MRI and CT scans indicated she was cancer free.. She and her family moved from Needham, Massachusetts, to Yardley, Pennsylvania, and by the end of 2014, she had recovered well enough to start working part time at the Hospital of the University of Pennsylvania. However, the leiomyosarcoma still lurked in her body, requiring a surgery to remove a tumor behind her left kidney in February 2015, with radiation treatment afterwards. More metastasis and more procedures, some experimental, followed.. "We all knew the odds were against her," said Dr Zuckerman, "but Hooman and Amy were both determined to beat the odds. They made it seem possible.". The end almost came in April when Dr Reed went into pulseless electrical activity cardiac arrest. As Dr ...
A woman presented with back pain, and when biopsied, she was found to have an inferior vena cava leiomyosarcoma - specifically involving the infrahepatic vena cava, the origin of the left renal vein, and the hilum of the right kidney. After undergoing preoperative proton beam radiation, the patient has her tumor resected en bloc by Dr. Vagefi and Dr. Haynes. They will also reconstruct the vena cava with a ringed synthetic graft covered by an omental pedicle flap ...
I have to share this bit of news because it truly changed my life. A few months ago, I went to my doctor and they detected a mass on my pelvic region. The doctor ordered more scans/imaging to decipher whether the mass was a leiomyoma or a leiomyosarcoma. Leiomyoma is also known as uterine fibroid.…
Hayashi T,Horiuchi A,Sano K,Hiraoka N,Kasai M,Ichimura T,Sudo T,Nishimura R,Ishiko O,. Shiozawa T,Kanai Y,Yaegashi N, Aburatani H,Konishi I:. Potential role of LMP2 as an anti-oncogeneic factor in human uterine leiomyosarcoma;. morphological significance of calponin h1.. FEBS Lett 586(13):1824-31, 2012. ...
Smooth Muscle Myosin Heavy Chain (SM-MHC) (Leiomyosarcoma & Myoepithelial Cell Marker) Antibody - W, Mouse Monoclonal Antibody [Clone SPM201 ] validated in IHC, IF, FC (AH11947-20), Abgent
Although the patient did not have any known risk factors, PE was assumed and anticoagulant therapy was initiated, while additional testing was being performed. A pulmonary scintigraphy was requested, which confirmed the absence of left lung perfusion and no changes in the right lung. Right heart catheterization confirmed severe pulmonary hypertension. However, both D-dimer and Doppler ultrasonography of the lower limbs were negative. Thrombophilia, inflammatory markers, tumor markers, and autoimmunity markers were also negative. After 3 months of anticoagulation, the patients dyspnea persisted. A follow-up CT angiogram showed an increase in the filling defect in the right pulmonary artery, along with isolated pulmonary infiltrates.. In view of his poor progress, a chest MRI with contrast medium was requested, showing a mediastinal mass with the same intensity as the muscles in T1, and hyperintense in T2 due to contrast uptake, suggestive of leiomyosarcoma of the pulmonary artery (Fig. 1b). The ...
Stomach and intestinal cancer (or leiomyosarcoma) is an uncommon, painful painful disease affects mostly older cats, though all breeds are equally predisposed. Learn more about the symptoms, causes and treatment for this condition on PetMD.com.
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Background: Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Although defined as a single group, they exhibit a wide range of clinical behaviour. We aimed to carry out molecular classification to identify new molecular subgroups with clinical relevance. Methods: We used gene expression profiling on 20 extra-uterine leiomyosarcomas and cross-study analyses for molecular classification of leiomyosarcomas. Clinical significance of the subgroupings was investigated. Results: We have identified two distinct molecular subgroups of leiomyosarcomas. One group was characterised by high expression of 26 genes that included many genes from the sub-classification gene cluster proposed by Nielsen et al. These sub-classification genes include genes that have ...
Primary pulmonary leiomyosarcomas are a rare malignant tumor with generally poor prognosis. They pose important problems of differential diagnosis especially with pulmona..
Abstract: Resistance to chemotherapeutic agents and radiotherapy has kept surgery the primary treatment of uterine leiomyosarcoma (ULMS). In search of leads for potential therapeutic targets, array CGH (aCGH) was used to obtain a genomewide pattern of ULMS-specific genetic imbalances and to define the affected biological processes. Fine-resolution genomewide aCGH analysis was performed using customised 16K cDNA microarrays on 18 primary ULMS cases. Furthermore, patterns of DNA copy number changes were assessed for associations with clinical parameters, i.e., tumour grade, tumour size and patient status at last follow-up. Our aCGH results demonstrated extensive DNA copy number changes in all chromosomes. Of the 10,590 gene loci included in the analysis, 4,387 were found to be affected by DNA copy number gains and 4,518 by DNA copy number losses in at least one case. Further analyses revealed that 231 of these were commonly gained, and 265 lost in at least 20% of the cases. The gains affected loci ...
Based on a review of 139 cases, Glasser29 found that myomectomy performed through a 3- to 6-cm minilaparotomy incision affords the advantage of same-day discharge as well as the ability to palpate the uterus and close the defect using a standard three-layered suturing technique. Those of us with uterine leiomyosarcoma are living a nightmare and may because of gynecologist who believe this fibroid non surgical removal We have a few natural remedies for fibroids for you to control any further complications in your condition, and help you heal your fibroids naturally. It aids the surgeon by allowing better visualization and handling of the fibroids.
1. Raish M, Khurshid M, Ansari MA. et al. Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization. J Cancer Res Clin Oncol. 2012;138:1173-1186 2. Dash DP, Silvestri G, Hughes AE. Fine mapping of the keratoconus with cataract locus on chromosome 15q and candidate gene analysis. Mol Vis. 2006;12:499-505 3. Birkenkamp-Demtroder K, Maghnouj A, Mansilla F. et al. Repression of KIAA1199 attenuates wnt-signalling and decreases the proliferation of colon cancer cells. Br J Cancer. 2011;105:552-561 4. He QY, Liu XH, Li Q. et al. G8: A novel domain associated with polycystic kidney disease and non-syndromic hearing loss. Bioinformatics. 2006;22:2189-2191 5. Yoshida H, Nagaoka A, Nakamura S. et al. N-terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199. FEBS Lett. 2014;588:111-116 6. Abe S, Usami S, Nakamura Y. Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed ...
Species: Mouse Immunogen: N-terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH. Clone: 1A4 Isotype: IgG2a, kappa Species Reactivity: Human, Baboon, Monkey, Cow, Pig, Sheep, Goat, Cat, Dog, Rabbit, Mouse, Rat, Guinea Pig and Chicken. Others not known. Positive Control: Blood vessels in all tissues, smooth muscle or leiomyosarcoma. Specificity: This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin. Status: ...
Species: Mouse Immunogen: N-terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH. Clone: 1A4 Isotype: IgG2a, kappa Species Reactivity: Human, Baboon, Monkey, Cow, Pig, Sheep, Goat, Cat, Dog, Rabbit, Mouse, Rat, Guinea Pig and Chicken. Others not known. Positive Control: Blood vessels in all tissues, smooth muscle or leiomyosarcoma. Specificity: This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin. Status: ...
Asad, H., Soslow, R. A. (2007). Histopathologic Prognostic Factors in Stage I Uterine Leiomyosarcoms (Ut-LMS); A Clinicopathologic Study of 28 Cases. Poster presented USCAP.. ...
Background: Uterine leiomyoma (ULM) and leiomyosarcoma (ULMS) are smooth muscle tumors with distinct clinical behavior that can cause infertility and even lead to death. Little is known about the factors that influence these tumors biology. Identification of new molecular markers can help in the differential diagnosis between ULM from low grade ULMS. It was demonstrated that activation of the Sonic Hedgehog (SHH) signaling pathway is related to the development of several tumors, through its activity in the cell proliferation and differentiation. Here, we investigated the protein expression profile of SHH, PTCH1, SMO and GLI1 both ULM (including non-typical leiomyomas) and ULMS. Methods: We selected 57 samples of ULMS and 30 samples of ULM (10 samples non-typical - ULMA). All tissues were used in TMA construction. Immunohistochemistry reaction was performed using monoclonal antibody against SHH (1:50), PTCH (1:100), SMO (1:100) and GLI-1 (1:200) using sodium citrate pH 6,0 in pressure cooker. ...
MRI is the modality of choice to allow proper tumoral delineation, evaluation of the local extent of the disease and its relationship to adjacent structures, to aid in surgical planning and to reduce surgical morbidity. Imaging findings of vulvar leiomyosarcomas are variable, such as of leiomyosarcomas in other locations. The tumour is usually described as a heterogeneous and irregularly-shaped mass with areas of high T2 signal due to cystic necrosis, and areas of high T1 signal due to haemorrhage. It often depicts heterogeneous contrast enhancement and areas of restricted diffusion on diffusion-weighted imaging. High signal intensity is detected on STIR sequences, without areas of fat [3 ...
The disease generally arises from the smooth, involuntary muscle that forms the walls of the womb, stomach, intestines, and blood vessels. It is a common type of sarcoma that can occur anywhere within the body.
This tumor was a 12 cm mass adherent to the small bowel, with hemorrhage and necrosis. Morphologically, it was a high grade and pleomorphic spindle cell tumor. The differential diagnosis includes leiomyosarcoma, symplastic leiomyoma and fibromatosis. Leiomyosarcomas have smooth muscle morphology, although this may not be obvious in high grade cases. Symplastic leiomyoma contains bizarre multinucleated tumor cells that may look malignant, but there are usually areas resembling typical leiomyoma, and there is no hemorrhage or necrosis. Both leiomyosarcomas and leiomyomas show some smooth muscle features by immunohistochemistry (smooth muscle actin or desmin positive), are negative for CD117 and CD34, and lack c-kit mutations. Intraabdominal fibromatosis has some overlapping features, but the morphology is different, with uniform cellularity composed of bipolar fibroblasts and myofibroblasts, and a background of distinct collagen with a mucopolysaccharide matrix containing thin walled, curvilinear ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The 2014 safety communications from the FDA made it clear that the organization felt that power morcellators were contraindicated for the removal of the uterus or fibroid tumor tissue. The group strongly advocated for surgeons to share this information with patients and to recommend a different course of action.. Though the emphasis has been strictly on uterine extraction and the cancer it has caused when done with power morcellators, it cannot be ignored that the devices have demonstrated other problems in the past.. For example, they are common tools in the laparoscopic surgeons arsenal, and yet they have proven to do damage to surrounding tissue and to cause male and female patients having spleen and liver procedures to experience problems, too. Just as they are believed to have easily spread LMS in uterine patients, the devices are also thought to cause certain types of cancer tissue and parasitic tissue to cause complications for patients having laparoscopic renal (nephrectomy) or spleen ...
This international study aim to identify new therapies and start promising clinical trials for the most common and clinically challenging types of LMS.