Philippine General Hospital, University of the Philippines Manila. Objective. This study aims to determine the prevalence and pattern of thyroid gland involvement in advanced laryngeal squamous cell carcinoma and to identify factors associated with its development.. Method. Records of 118 patients who underwent laryngectomy with thyroidectomy for advanced laryngeal squamous cell carcinoma in a tertiary government hospital from January 2010 to August 2015 were reviewed. Demographic, clinical and histopathology data were obtained. The relationship of the laterality of primary tumor bulk and lobe involvement was analyzed using Fischers exact test. The association between thyroid gland invasion and other factors was analyzed using logistic regression.. Results. Thyroid gland involvement was found in 11% of the patients via direct spread in 92.3%. Single lobe involvement accounted for 61.5% of cases. There is a tendency for laryngeal squamous cell carcinoma to invade the thyroid lobe ipsilateral to ...
Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas.
The aim of the present study was to identify specific serum miRNAs (preoperative serum samples compared to healthy controls) as potential diagnostic markers for detection in laryngeal squamous cell carcinoma (LSCC). Serum samples obtained from 66 patients with LSCC were compared with 100 healthy control subjects. Additionally, miRNA levels were evaluated to identify possible correlations with clinicopathological features. The expression of 377 miRNAs (screening set) was evaluated by microarray screening. The most differentially expressed miRNAs were validated by high-throughput real-time quantitative polymerase chain reaction (RT-qPCR) in the group of LSCC patients and healthy controls. Receiver-operator characteristic (ROC) curve analysis was conducted to evaluate the diagnostic accuracy of the highly and significantly identified deregulated miRNA(s) as potential candidate biomarker(s). According to the array analysis, eleven miRNAs revealed an altered expression profile. The levels of serum expression
Laryngeal squamous cell carcinomas (LSCC) are frequently occurring cancers with a high risk of local recurrences or second primary tumours developing within the first two years of diagnosis. A common feature of LSCC is the epigenetic inactivation of certain genes by promoter hypermethylation. In a previous study we found associations of promoter methylation with some clinical features of LSCC. The present study aimed at assessing promoter hypermethylation of CDKN2A, MGMT and MLH1 as prognostic factors in LSCC patients. ...
Laryngeal squamous cell carcinomas (LSCC) are frequently occurring cancers with a high risk of local recurrences or second primary tumours developing within the first two years of diagnosis. A common feature of LSCC is the epigenetic inactivation of certain genes by promoter hypermethylation. In a previous study we found associations of promoter methylation with some clinical features of LSCC. The present study aimed at assessing promoter hypermethylation of CDKN2A, MGMT and MLH1 as prognostic factors in LSCC patients. ...
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse. Human papilloma
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This page includes the following topics and synonyms: Laryngeal Neoplasm, Laryngeal Tumor, Vocal Cord Cancer, Squamous Cell Carcinoma of the Larynx, Laryngeal Cancer, Laryngeal Squamous Cell Carcinoma.
Background: Laryngeal cancer is an important malignancy in head and neck area and squamous cell carcinoma(SCC) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) indifferent tumors and their correlation with tumor invasiveness has been documented. However, most studieshave evaluated MMP-2 and MMP-9 expression and few have evaluated serum levels. The aim of current studywas to evaluate serum levels in patients with laryngeal SCC compared to normal subjects and assess any relationwith tumor clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oralSCC and 20 healthy subjects were included. Serum levels of MMP-2 and MMP-9 were compared between groupsand correlations with findings including grade (T) and node involvement (N) were evaluated. Results: Patientswith laryngeal SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p=0.03) comparedto healthy subjects. Patients with higher T stage (T3,4) had
WEDNESDAY, Dec. 14, 2016 (HealthDay News) - For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in Head & Neck.. Aaro Haapaniemi, M.D., from Helsinki University Hospital in Finland, and colleagues analyzed a nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005. Data were included for 316 patients with initial successful therapy.. The researchers found that 22 percent of patients had laryngeal SCC recurrence. The median time to recurrence was nine months, and 90 percent occurred within 36 months following treatment. Independent prognostic factors for recurrence included the World Health Organization performance status ,0, neck metastasis at presentation, and nonsurgical treatment. Five-year overall survival was 53 percent for patients with local recurrence and 5 percent for patients with regional/distant ...
Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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E-mail: [email protected], [email protected] Abstract. Salmonella entericais an ultimative human pathogen that causes various health problems. On the other hand, Lactobacillus plantarumhas numerous positive effects on human health. The objective of this study was to investigate the influence of enterobacteriaS. entericaLT21 on human laryngeal carcinoma cell line (HEp2). The ability of the adhesion of S. entericaLT21 as an independent culture and in combination with L. plantarum16.4 to HEp2 cells was tested as well as metabolic activity of S. entericaLT21 after adhesion to HEp2 cells. The protein content in HEp2 cells after the incubation with S. entericaLT21 was investigated and compared with the protein content in the untreated HEp2 cells. Adhesion results show better binding of S. entericaLT21 than L. plantarum16.4 when bacteria are mixed in a 1:1 and 10:1 ratios, respectively. Acetic and lactic acid in the sample of HEp2 cells incubated with S. entericaLT21 were detected, as well as lactic ...
Personalized treatment strategies for laryngeal cancer based on tumor response after a single cycle of neoadjuvant chemotherapy ups survival.
BACKGROUND The aetiology and factors leading to the progression of laryngeal cancer are still unclear. Although human papillomavirus (HPV) has been suggested to play a role, reports concerning the effect of HPV infection on tumour development are controversial. Recently, transfusion transmitted virus (TTV) was suggested to play a role in certain infections as a causative or coinfecting agent. AIMS To investigate whether the development and progression of laryngeal squamous cell carcinoma is associated with coinfection with TTV and HPV. METHODS The prevalence of TTV and HPV was investigated using the polymerase chain reaction in tissue samples from 40 healthy individuals, 10 patients with recurrent papillomatosis, five patients with papillomatosis with malignant transformation, and 25 patients with laryngeal carcinoma. The obtained prevalence data were compared and analysed statistically. RESULTS In the 11 patients with carcinoma who had metastasis or relapse there was a high rate of coinfection
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Patients with comorbidities do not receive optimal treatment for their cancer, leading to lower cancer survival. Information on individual comorbidities is not straightforward to derive from population-based administrative health datasets. We described the development of a reproducible algorithm to extract the individual Charlson index comorbidities from such data. We illustrated the algorithm with 1,789 laryngeal cancer patients diagnosed in England in 2013. We aimed to clearly set out and advocate the time-related assumptions specified in the algorithm by providing empirical evidence for them.. METHODS ...
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes associated with acquired radioresistance. In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. The cell cycle, clonogenicity, tumor growth in mice and DNA damage-repair were assessed. Mitochondrial DNA (mtDNA) was sequenced. In a bottom-up approach, matched glycolytic and oxidative SQD9 cells were generated using FACS-sorting, and tested for their radiosensitivity/radioresistance. We found that acquired radioresistance is associated with a shift from a glycolytic to a more oxidative metabolism in SQD9 cells. The opposite was also true, as the most oxidative fraction
Laryngeal squamous cell carcinoma (LSCC) is the most common form of malignant disease in the head and neck region characterized by the frequent occurrence of metastases in the neck lymph nodes early in the disease progression. This form of cancer is characterised with numerous genetic abnormalities and changes in expression levels of proteins and glycoproteins associated with the process of carcinogenesis. Despite numerous findings molecular mechanism of metastatic disease has not yet been fully elucidated. In addition, there is increasing evidence that abnormal expression and glycosylation of proteins result of initial malignant transformation of cells, and aberrant glycosylation is one of the key events in the invasion and metastasis of many malignant diseases. In addition, there is increasing evidence indicating that abnormal expression and glycosylation of proteins is a result of cellular initial malignant transformation, and aberrant glycosylation is one of the key events in the invasion ...
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. General Information About Laryngeal Cancer. Updated statistics with estimated new cases and deaths for 2017 (cited American Cancer Society as reference 1).. Treatment Option Overview for Laryngeal Cancer. Added subsection title and text to state that surgery and radiation therapy have been the standards for treatment of laryngeal cancer but outcome data from randomized trials are limited; underpowered studies have not fully addressed whether to use surgery or radiation (cited Iyer et al. as reference 1). Also added that selection of primary surgery versus radiation therapy-based treatment should be made in a multidisciplinary setting with consideration of disease stage, comorbidities, and functional status, including voice and swallowing outcomes and lung capacity.. Added text to state that prospective ...
Thesis, English, Potential role of Bcl 2 and Ki 67 expressions in predicting the response to radiotherapy of T1 and T2 clinical stages of laryngeal squamous cell carcinoma for Ezzo Eman Mohamed Hassan
To test whether the distribution of AHH inducibility is shifted toward the high end of the range in patients who had lung and laryngeal cancer, we measured this trait in 59 patients (32 lung and 27 laryngeal) who had resectable tumors and had been disease-free for a period of time. The advantage of selecting patients who were free of clinical disease was that measurement of their AHH inducibility should not have been affected by the disease state. Patient and control populations showed no difference in basal and induced AHH activity of AHH inducibility. The mean AHH inducibility in patients who had lung cancer was 3.20 +/- 0.20; in patients who had laryngeal cancer 2.96 +/- 0.18, and for all controls 3.29 +/- 0.04 (no significant difference at p = 0 05). Further analysis of the distribution of AHH inducibility in the patient group compared to controls showed no suggestion of a shift toward the higher end of the range in patients who had lung and laryngeal cancer.
Tumours of head and neck belong to the most frequent types of cancer world-wide. In Poland, mortality from larynx cancer among males has been continuously increasing during the last decades up to 8.4 deaths per 100,000 men in 1993, which exceeds epidemiological records from other countries. The aetiology of laryngeal cancer is strongly associated with exposure to carcinogens present in tobacco smoke. The review describes a sequence of molecular and cellular events from carcinogenic exposure, DNA adduct formation, detection of mutations in the p53 gene, loss of heterozygosity (LOH) in chromosomal loci encoding the p53 and p16 genes, and loss of control of the cell cycle. The section concerning DNA adducts includes a discussion of the role of such confounders as exogenous exposure, the age and sex of the subject, and disease progression. The significance of genetic factors as individual risk determinants is discussed in relation to bleomycin-induced chromosome instability and in connection with ...
1. Torre LA, Bray F, Siegel RL. et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87-108 2. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7-30 3. Chen W, Zheng R, Baade PD. et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115-32 4. Wong TS, Gao W, Li ZH. et al. Epigenetic dysregulation in laryngeal squamous cell carcinoma. J Oncol. 2012;2012:739461 5. Shimura T, Kakuda S, Ochiai Y. et al. Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys. 2011;80:540-8 6. Li Z, Yang X, Xia N. et al. PTOP and TRF1 help enhance the radio resistance in breast cancer cell. Cancer Cell Int. 2014;14:7 7. Zhou FX, Xiong J, Luo ZG. et al. cDNA expression analysis of a human radiosensitive-radioresistant cell line model identifies telomere function as a hallmark of radioresistance. Radiat Res. 2010;174:550-7 8. Kim JS, Chang ...
TY - JOUR. T1 - Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. AU - Ljumanovic, R.. AU - Langendijk, J.A.. AU - Hoekstra, O.S.. AU - Knol, D.L.. AU - Leemans, C.R.. AU - Castelijns, J.A.. PY - 2008. Y1 - 2008. U2 - 10.1007/s00330-008-0986-x. DO - 10.1007/s00330-008-0986-x. M3 - Article. C2 - 18491097. VL - 18. SP - 2231. EP - 2240. JO - European Radiology. JF - European Radiology. SN - 0938-7994. IS - 10. ER - ...
Laryngeal cancer represents the malignant degeneration, of epithelial nature or from the connective tissue, which starts in the constitutive elements of the larynx. Cancer localization in the larynx represents between 1% and 3% of all malignant tumors and approximately 50% of ear, nose and throat (ENT) tumors. Squamous cell carcinoma is the most common form (around 95%) of laryngeal cancer, with high incidence in human males from southern and central Europe, Romania occupying one of the top places. Material and Methods. Our study consisted of 490 patients diagnosed with laryngeal cancer from 2010 to 2016. They have been clinically, histologically, immunohistochemically, genetically, therapeutically and prognostically analyzed. Suspended microlaringoscopy has been the standard, allowing tumor extension evaluation and biopsy. All specimens were microscopically analyzed in standard or special histology stainings. For unclear histology specimens, immunohistochemical stainings were performed. Results and
Stage I larynx cancer can be treated with surgery or radiation therapy. When radiation therapy is used, surgery is reserved for cancer recurrence.
PURPOSE: Retrospective studies indicate that larger tumour volume is a strong prognostic indicator for poor tumour control after (chemo)radiotherapy for laryngeal cancer. The impact of tumour volume on the outcome of patients treated within a prospective study comparing accelerated radiotherapy (AR)+/-carbogen breathing and nicotinamide (ARCON) was investigated. METHODS AND MATERIALS: Of 345 patients with cT2-4 laryngeal cancer, pre-treatment computed tomography (CT) scans of 270 patients were available for tumour volume calculation. Contouring of the primary tumour and involved lymph nodes was reviewed by one experienced head and neck radiation oncologist. Kaplan-Meier plots were used for analysis of outcome. RESULTS: Of 137 AR and 133 ARCON patients, 57 and 80 versus 56 and 77 patients had glottic and supraglottic tumours, respectively. A correlation between primary tumour volume and T-stage was observed (Rs=.51, P,.01). In both treatment arms no correlation was detected between the primary ...
Laryngeal cancer: what signs accompany all stages of the disease? Laryngeal cancer is a disease characterized by the formation of malignant cells in the tissues that are
The DeLOS II trial is a multicenter randomised phase II trial investigating a TP/5-Fluorouracil (TPF)-chemotherapy with or without cetuximab for Patients with only by laryngectomy operable carcinoma of the larynx/hypopharynx. Patients were divided in responder or non-responder after 4 weeks. Since August 2009 Responder receive TP with or without Cetuximab + radiation. (Until february 2009 Responder received TPF with or without Cetuximab + radiation.) Planned accrual is 85 patients per treatment arm. The primary study endpoint is a confirmatory proof of an adequate survival rate with a functionally larynx-conserving 2 years after randomisation ...
The DeLOS II trial is a multicenter randomised phase II trial investigating a TP/5-Fluorouracil (TPF)-chemotherapy with or without cetuximab for Patients with only by laryngectomy operable carcinoma of the larynx/hypopharynx. Patients were divided in responder or non-responder after 4 weeks. Since August 2009 Responder receive TP with or without Cetuximab + radiation. (Until february 2009 Responder received TPF with or without Cetuximab + radiation.) Planned accrual is 85 patients per treatment arm. The primary study endpoint is a confirmatory proof of an adequate survival rate with a functionally larynx-conserving 2 years after randomisation ...
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Laryngeal cancer, which typically forms in the squamous cells that line the inside of the larynx, makes up about 2 to 5 percent of diagnosed cases of cancer every year. It is about twice as common in men as it is in women, and it usually occurs in people older than 50.
Treatment of laryngeal cancer with chemotherapy 1 course (costs for program #250581) ✔ University Hospital Halle (Saale) ✔ Department of Hematology and Oncology (Department of Internal Medicine IV) ✔ BookingHealth.com
Learn more about Laryngeal Cancer at TriStar Centennial DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Background: Tobacco smoking and alcohol drinking generate oxidative DNA damage and may contribute to larynx carcinogenesis. The X-ray repair cross complementing
Greg had no surgery because his tumor was T4 Ni MO ,they said the tumor was to big, he does not have a J-tube nor a pic line . He lost his voice but after the treatment his voice came back. They did 7 weeks of Radation and Chemo (Cisplatin ) March to May 2009, May 2010 the cancer spread to his lungs so we are doing treatment for that. I do understand that since it was Larynx cancer that it is still Larynx cancer but Mets to the Lungs(Both ...
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Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormal tissue or cancer is found early, it may be easier to treat. By the time symptoms appear, cancer may have begun to spread. Scientists are trying to better understand which people are more likely to...
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Se estudian los par metros que influyen en la calidad de vida de los pacientes con c ncer lar ngeo, como los trastornos de la comunicaci n y la boca seca. Luo J1, Wu J, Lv K, Li K, Wu J, Wen Y, Li X, Tang H, Jiang A, Wang Z, Wen W, Lei W.: Analysis of Postsurgical Health-Related Quality of Life and Quality of Voice of Patients With Laryngeal Carcinoma. Medicine (Baltimore). 2016 Jan;95(1):e2363. ...
For some patients with larynx cancer, the disease persists or recurs after surgery, radiation and chemotherapy. Additional surgery often results in poor survival. Immunotherapy treatments can work sometimes, but which patients should receive the treatment before additional surgery? Now, researche
How much cigarette smoking causes lung cancer? Turns out that a pack a day for five years is the critical tipping point where smokers are twice as likely as non-smokers to get lung, throat and larynx cancers. This precedent-setting calculation figured ...
Laryngeal cancer is caused by smoking. In America, 11,000 new cases are reported daily. It makes up 25% of head and neck cancers and 1% of all types of cancer. One third of the patients died because of difficulty in breathing and most are at the age of 60 - 70 years old. The ratio between men and women is 4: 1 and most of them are smokers ...
Abstract Full Text Similar Articles Mail to Editor THE PRELIMINARY RESULTS OF RADIOTHERAPY IN EARLY STAGE (T1-T2) LARYNGEAL CANCER MEHMET ŞEN, İLKNUR BİLKAY, SEMİH SÜTAY, ATAMAN GÜNERİ, HİLMİ ALANYALI, UFUK GÜNBAY, KERİM CERYAN, RIZA ÇETİNGÖZ, UĞUR PABUÇCUOĞLU, EMEL ADA, İLHAMİ KOVANLIKAYA, SÜLEN SARIOĞLU, FADİME AKMAN, MÜNİR KIRAY ...
Abstract Full Text Similar Articles Mail to Editor THE PRELIMINARY RESULTS OF RADIOTHERAPY IN EARLY STAGE (T1-T2) LARYNGEAL CANCER MEHMET ŞEN, İLKNUR BİLKAY, SEMİH SÜTAY, ATAMAN GÜNERİ, HİLMİ ALANYALI, UFUK GÜNBAY, KERİM CERYAN, RIZA ÇETİNGÖZ, UĞUR PABUÇCUOĞLU, EMEL ADA, İLHAMİ KOVANLIKAYA, SÜLEN SARIOĞLU, FADİME AKMAN, MÜNİR KIRAY ...
ATCC supplies a wide variety of cultures, reagents, and services used as tools for lung, bronchial, and laryngeal cancer research