According to the latest report published by Credence Research, Inc. Lab-on-a-Chip Market - (Product Type - DNA Microarrays, Lab on a chip/Microfluidics, Protein Microarrays, Tissue Biochip, Carbohydrate Biochips; Application Type - Genomics & Proteomics, Diagnostics, Drug Discovery, Others); Market Growth, Future Prospects and Competitive Analysis, 2017-2025 the market was valued at USD 4.16 Bn in 2015, and is expected to reach USD 9.06 Bn by 2025, expanding at a CAGR of 8.9% from 2017 to 2025.. Browse the full report Lab-on-a-Chip Market: Market Growth, Future Prospects and Competitive Analysis, 2017-2025 report at http://www.credenceresearch.com/report/lab-on-a-chip-market. Market Insights. A biochip is a device which assimilates one or more laboratory tasks on a sole chip to achieve high-throughput screening and automation. Advances in the field of nanotechnology have led to the development of lab-on-a-chip devices. Lab-on-a-chip can integrate several laboratory function in a few ...

During the last few years there has been a rapid increase in the use of electrochemical reactions in lab-on-a-chip devices. This development, which has so far mainly focussed on electrochemical detection in chip-based capillary electrophoresis, can be explained by the fact that electrochemical techniques and devices are particularly well-suited for inclusion in lab-on-a-chip systems. The most important reason for this is that the required electrodes can readily be manufactured and miniaturised without loss of analytical performance using conventional microfabrication methods. In this Research Highlight article, the developments during the last three years concerning electrochemical techniques for lab on-a-chip applications are discussed, with particular focus on emerging electrochemical methods for sample clean-up and preconcentration, electrochemical derivatisation and electrochemical detection in chip-based capillary electrophoresis.

Heart Failure Point-of-care and Lab-on-a-chip Devices Market is driven by high demand for diagnosis and treatment of various heart diseases and increase in demand for diagnostic services.

Read reviews and compare manufacturers of Lab-on-a-Chip > Lab-on-a-Chip Microarray products in the SelectScience products and suppliers directory

Een lab-on-a-chip (LOC) is een miniatuur laboratoriumsysteem dat binnen en buiten het ziekenhuis voor verschillende medische doeleinden wordt gebruikt. Voorbeelden zijn het bepalen van bloedwaarden, het bloedglucose- en cholesterolgehalte of het aantal HIV-cellen. Het RIVM heeft de state of the art van dergelijke LOCs beschreven, inclusief een overzicht van producten die op de markt zijn of binnenkort verwacht worden. Hieruit blijkt dat deze producten sterk in ontwikkeling zijn en het aanbod in de nabije toekomst verder zal toenemen. Het onderzoek is uitgevoerd in opdracht van de Inspectie voor de Gezondheidszorg (IGZ).,br, ,br,Naar verwachting levert het gebruik van LOCs voordelen op ten opzichte van de huidige testwijze in klinisch diagnostische laboratoria. De belangrijkste zijn dat ze het mogelijk maken om op locaties waar dit direct gewenst is snel een diagnose te stellen (point-of-care), en dat er minder monsters en materialen nodig zijn om de tests uit te voeren. Wel is aandacht nodig ...

Presentations will explore the latest advances in the Lab-on-a-Chip and Microfluidics Fields. Focus at this conference will also be given to some of the many applications of Lab-on-a-Chip, from life science research, to taking diagnostics to the point-of-care/point-of-need and body-on-a-chip/organs-on-a-chip. We focus on LOAC device production technologies, novel designs/technologies for manufacture, as well as the key application areas for LOAC from research to diagnostics. There is an Extensive International Perspective at this Conference with Speakers, Poster Presenters, Sponsors, and Exhibitors from the US, Europe, and Asia/Pacific ...

Shih and his team developed DMF technology that can automate the synthetic biology process of design-build-test-learn. Digital microfluidics involves miniaturized lab-on-a-chip devices.. Normally the size of a credit card, they are used to integrate several laboratory functions onto a single chip as small as a few nanolitres of fluid. By manipulating very small volumes of fluid on electrodes using voltage, we have a powerful tool that allows us to perform several medical tests in one shot, and address challenging problems in health care, says the founder of the Shih Microfluidics Laboratory.. Our device will radically speed up lab analysis and research.. Cancer research is one example of how DMF technology can be applied. Researchers can take a sample of cells - usually a tiny droplet of cells that researchers believe are going to help us understand cancer better - and put them directly on the DMF device with an array of electrodes.. Trying to obtain cells related to diseases like ...

Elias and her colleagues conducted a number of preliminary LCP experiments on a microscale in order to better understand and describe the materials mechanical properties. They believe the material holds promise as a microscale building block. Its now up to other engineers and scientist to take this knowledge and create useful microscale devices. The most commonly cited goal among micro- and nanoscale researchers is to create a lab-on-a-chip - a tiny system that could be used, for example, to analyze blood samples and biopsies much faster, cheaper and more comprehensively than current methods.. In the past, most microscale research and development funds have targeted silicon, the fundamental material in the semiconductor industry. But LCPs are less brittle and more pliable than silicon, Elias said, adding that LCP devices could be tailored to respond to specific external stimuli, such as temperature changes and UV radiation exposure, which could makes them easier to activate than silicon. And, ...

We review microfluidic platforms that enable the miniaturization, integration and automation of biochemical assays. Nowadays nearly an unmanageable variety of alternative approaches exists that can do this in principle. Here we focus on those kinds of platforms only that allow performance of a set o …

A simple, self-powered, lab-on-a-chip device that could enable diagnoses of several diseases, which is both affordable and accessible even in resource-constrained settings, has successfully passed preclinical trials, thanks to research done by a team of scientists from the Indian Institute of Technology, Madras (IIT-M).. A team led by Prof. Ashis Kumar Sen, the corresponding author of the paper from the Department of Mechanical Engineering, IIT Madras, used a 2-cm-long microchannel device that employs capillary force to draw blood into the device to separate plasma from whole blood and test glucose level in diabetic patients.. The first part of the microchannel device has hydrophilic walls (top and two side walls) that help the blood sample to be drawn in through capillary force. But one centimetre away, all the four walls of the microchannel are hydrophobic. Like a drop of water on a Teflon surface, the blood comes together and forms a large contact angle (more than 90 degrees) when it enters ...

Cartilage injuries cause pain and loss of function, and if severe may result in osteoarthritis (OA). 3D bioprinting is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. Our team has developed a handheld device, the Biopen, to allow in situ additive manufacturing during surgery. Given its ability to extrude in a core/shell manner, the Biopen can preserve cell viability during the biofabrication process, and it is currently the only biofabrication tool tested as a surgical instrument in a sheep model using homologous stem cells. As a necessary step toward the development of a clinically relevant protocol, we aimed to demonstrate that our handheld extrusion device can successfully be used for the biofabrication of human cartilage. Therefore, this study is a required step for the development of a surgical treatment in human patients. In this work we specifically used human adipose derived mesenchymal stem cells (hADSCs), harvested from the

Miniaturization, requiring use of Microfluidics or Lab-on-a-Chip Technology has proven to have specific advantage in expediting early stages of drug discovery process. Extension of bioassay and cell biology possibilities, better separation techniques, relatively accurate modeling of physiological situations and systematic high-volume testing have all turned out to facilitate drug discovery. The use of Robotic fluid handling with micro total analysis systems (µTAS) integrating biomarker technology has brought paradigm shift in disease diagnosis and drug discovery and development processes. After the first full conference in Bangalore in September 2013, we at SELECTBIO, are delighted to bring together thought leaders in the field of Microfluidics & Lab-on-a-Chip India in Mumbai, on January 22-23, 2015. The program will consist of moderated sessions and engaging an expert panel on research themes at the core of Microfluidics and Lab-on-a-Chip technology. The conference will be co-located with Flow ...

Imagine if you needed to quickly determine whether a soldier in a battlefield had been exposed to a biochemical agent, said J. Alex Chediak, a UC Berkeley graduate student in materials science and engineering and lead author of the paper. You dont have time to take a sample of his blood back to the lab and wait for results. This device could be developed into something medics use in the field to get answers in a matter of minutes, not hours. UC Berkeley has recently filed a provisional patent application on the new device, which is described in the March 1 issue of Sensors and Actuators A. The National Science Foundation supported the research, led by Timothy Sands, a professor of engineering at Purdue University who conducted the work while he was a professor of materials science and engineering at UC Berkeley. The lab-on-a-chip device uses fluorescence microscopy to signal the presence of target molecules in a sample. If molecules of a specific substance - such as an avian flu virus or ...

A wirelessly powered and controlled biased-AC electroosmotic (biased-ACEO) lab-on-a-film (LOF) is presented here for particle and fluid manipulation. Amplitude modulation (AM) and inductive coupling are used for wireless transmission of low frequency signals required for excitation of biased-ACEO effects employed by the LOF for microfluidic functions. The LOF consists of a receiving coil (for receiving inductively transmitted high frequency signals), surface mounted devices (for recovering a low frequency AC signal) and an array of interdigitated electrodes (IDE, for excitation of biased-ACEO effects). Unlike existing wireless lab-on-a-chip devices that have cumbersome set-ups, require high voltages and perform only one microfluidic function, the presented LOF has a compact and flexible structure, works at very low voltage ranges, and can perform several microfluidic operations corresponding to a wirelessly-controlled voltage. When the level of the demodulated signal over the IDE is about 0.7 V, ...

Near field generated by plasmonic structures has recently been proposed to trap small objects. We report the first integration of plasmonic trapping with microfluidics for lab-on-a-chip applications. A three-layer plasmo-microfluidic chip is used to demonstrate the trapping of polystyrene spheres and yeast cells. This technique enables cell immobilization without the complex optics required for conventional optical tweezers. The benefits of such devices are optical simplicity, low power consumption and compactness; they have great potential for implementing novel functionalities for advanced manipulations and analytics in lab-on-a-chip applications.. ©2009 Optical Society of America. Full Article , PDF Article ...

We present a novel, low-resource fabrication and assembly method for creating disposable amperometric detectors in hybrid paper-polymer devices. Currently, mere paper-based microfluidics is far from being able to achieve the same level of process control and integration as state-of-the-art microfluidic devic

Bio-MEMS is an abbreviation for biomedical (or biological) microelectromechanical systems. Bio-MEMS have considerable overlap, and is sometimes considered synonymous, with lab-on-a-chip (LOC) and micro total analysis systems (μTAS). Bio-MEMS is typically more focused on mechanical parts and microfabrication technologies made suitable for biological applications. On the other hand, lab-on-a-chip is concerned with miniaturization and integration of laboratory processes and experiments into single (often microfluidic) chips. In this definition, lab-on-a-chip devices do not strictly have biological applications, although most do or are amendable to be adapted for biological purposes. Similarly, micro total analysis systems may not have biological applications in mind, and are usually dedicated to chemical analysis. A broad definition for bio-MEMS can be used to refer to the science and technology of operating at the microscale for biological and biomedical applications, which may or may not include ...

Proteins at interfaces play a major role in biomaterials and lab-on-a-chip devices. Protein interactions with the surface change their conformations and therefore their ability to bind to their respective ligands. Another major area of interest surrounding biomaterials and lab-on-a-chip devices is the prediction and prevention of wear. Wear is the progressive loss of material from an object caused by contact and relative movement of the contacting solid, liquid, or gas. It is estimated that wear costs 1% of the gross domestic product (approximately $150 billion for the US). With the emergence of drug-releasing implants and lab-on-the-chip devices, wear has also become a major concern in bio- and nano- technology. In our laboratory, we use microtubules (filamentous proteins) gliding on kinesin motor proteins as transporters in biosensors. This system, known as the motility assay, is ideal for studying how the conformation of kinesins impacts the gliding of microtubules and therefore the performance of

The Global Lab-on-a-Chip Device Market poised to grow from US$ XX million in 2021 to US$ XX million by 2027 at a compound annual growth rate (CAGR) of XX% during the projection period of 2021-2027. The report states that the Lab-on-a-Chip Device market condition and market forces acting across the industry. Analysts use the most recent primary and secondary research techniques and tools to arrange comprehensive and accurate marketing research reports. The research study also includes other types ...

Lab-on-a-chip devices As lab-on-a-chip devices get ever more sophisticated and are linked together into ever more complex systems able to perform ever more functions, there is an increasing need to switch between different solvents. For example, synthesizing a drug in a series of microreactors might need different solvents at different stages in...

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This thesis contributes to the development of Lab-on-a-Chip systems that enables reliable, rapid medical diagnostics at the point-of-care. These contributions are focused on microfluidic Lab-on-a-Chip systems for sepsis diagnosis, autonomous sample-to-answer tests, and dried blood spot sampling.. Sepsis is a serious condition with high mortality and high costs for society and healthcare. To facilitate rapid and effective antibiotic treatment, improved sepsis diagnostics is needed. Diagnosis of sepsis requires the processing of relatively large blood volumes, creating a need for novel and effective techniques for the handling of large volume flows and pressures on chip. Components, materials, and manufacturing methods for pneumatically driven Lab-on-a-Chip systems have therefore been developed in this thesis. Microvalves, an essential component in many Lab-on-a-Chip systems have been the focus on several of the advances: a novel elastomeric material (Rubbery Off-Stoichiometric-Thiol-Ene-Epoxy) ...

By taking advantage of the natural movement of liquid through paper, researchers at Harvards Whitesides Research Group may have found a way to make microfluidics technology much cheaper. The result could be disposable diagnostic tests simple and abundant enough for use in the developing world.. The field of microfluidics deals with the precise manipulation of tiny quantities of liquid. One of its most promising applications is the so-called lab-on-a-chip, which can work with much smaller fluid samples than larger devices require, potentially allowing for more portable diagnostic tools. But existing microfluidic chips are generally made from comparatively expensive materials like silicon, glass, or plastic and have tiny pumps and valves that can be difficult to manufacture.. Now, Harvards George Whitesides and his team have built a microfluidic device on a square of paper the size of a pinky fingernail. Its the first example Ive heard of paper microfluidics, says Albert Folch, a bioengineer ...

biofabrication talk - In his biofabrication talk, Andras Forgacs explains the science behind creating leather and food in a lab and its societal implications. Currently,...

have devised a microscale tool to help them understand the mechanical behavior of biofilms, slimy colonies of bacteria involved in most human infectious diseases.. Most bacteria in nature take the form of biofilms. Bacteria are single-celled organisms, but they rarely live alone, said John Younger, associate chair for research in the Department of Emergency Medicine at the U-M Health System. Younger is a co-author of a paper about the research that will be the cover story of the July 7 edition of Langmuir.. The new tool is a microfluidic device, also known as a lab-on-a-chip. Representing a new application of microfluidics, the device measures biofilms resistance to pressure. Biofilms experience various kinds of pressure in nature and in the body as they squeeze through capillaries and adhere to the surfaces of medical devices, for example.. If you want to understand biofilms and their life cycle, you need to consider their genetics, but also their mechanical properties. You need to think of ...

The rapid identification of algae species is not only of practical importance when monitoring unwanted adverse effects such as eutrophication, but also when assessing the water quality of watersheds. Here, we demonstrate a lab-on-a-chip that functions as a compact robust tool for the fast screening, real-time monitoring, and initial classification of algae. The water-algae sample, flowing in a microfluidic channel, is side-illuminated by an integrated subsurface waveguide. The waveguide is curved to improve the device sensitivity. The changes in the transmitted optical signal are monitored using a quadrant-cell photo-detector. The signal-wavelets from the different quadrants are used to qualitatively distinguish different families of algae. The channel and waveguide are fabricated out of a monolithic fused-silica substrate using a femtosecond laser-writing process combined with chemical etching. This proof-of-concept device paves the way for more elaborate femtosecond laser-based optofluidic ...

Microfluidics in Detection Science: Lab-on-a-chip Technologies Microfluidics in Detection Science: Lab-on-a-chip Technologies ...

Read user reviews, compare products and contact manufacturers of Lab-on-a-Chip products, including gene chips, RNA arrays and microarray systems on SelectScience.

Controlled cavitation is the basis for the new technique: using a laser, a bubble is induced in the micro channel, by local heating and low pressure. This bubble has a short life: it rapidly implodes caused by the higher pressure in the channel. This causes the fluid flow to go up to 20 meters per second. Near a channel wall, the effect is spectacular. There a jet is formed, together with to tiny bubbles around which a strong circular flow forms. This is an ideal way of mixing fluids.. Simple and fast. In micro fluidics, other physical laws become dominant over those valid for large-scale systems. Viscous forces take over, and this implies that often additional components -for example micromechanical devices- are necessary for mixing and speeding up the flow. Those components , in turn, require additional electronics and wiring and can make a lab-on-a-chip fairly complicated. The laser can be directed to any spot where mixing or acceleration is needed, this is even made easier by the fact that ...

A breakthrough lab-on-a-chip technology developed by IBM Research scientists could enable doctors to detect diseases like cancer before symptoms even appear.. The system, described in the journal Nature Nanotechnology, can separate biological particles down to 20 nanometers in diameter, a scale that gives access to important particles like DNA, viruses and exosomes. Once separated, these particles could then potentially be analysed by doctors to reveal signs of disease earlier than ever before and when outcomes for treatment are most positive.. After originally focusing on exosomes, which can be captured non-invasively by liquid biopsies and are increasingly being viewed as useful biomarkers for malignant tumours, IBMs next step is to confirm - with the help of a team from the Icahn School of Medicine at Mount Sinai in New York, US - that their device is able to pick up exosomes with cancer-specific biomarkers.. By targeting exosomes, we anticipate our lab-on-a-chip technology can give ...

NHLBI-funded researchers have developed a suite of lab-on-a-chip tests that allow the quick screening of newborn blood samples for the presence of rare diseases using a tiny blood sample. The technology could greatly expand newborn exams for rare diseases, including potentially life-threatening diseases that could affect the heart, lung, and blood.

The aim of this Cost Action MP1205 is to establish active interlinks between laboratories working in the fields of micro and optofluidics, optical tweezers, nanoscience and photonics, bio and soft materials, focusing their work towards lab-on-a-chip systems and at promoting long-term development of these fields in Europe. The goal is to increase the knowledge in basic physics and biology from the micro- down to the nano-scale, and to develop the future generation of lab-on-a-chip devices for portable and inexpensive, but accurate and reliable equipments for: (i) diagnostics; (ii) detection, identification and manipulation of biomolecules and nanomaterials, (iii) biomedical and environmental microsensing, (iv) advanced imaging, (v) energy generation.. The scientific innovation concerns advanced concepts of optofluidics and new generation of optofluidic devices integrating photonics as well as optical control. Indeed, their technologically relevant research threads are of significant interest for ...

Title:Opinion Paper: Microfluidics Technique to Revolutionize the Drug Delivery Field: Current Developments and Applications. VOLUME: 12 ISSUE: 6. Author(s):Hélder A. Santos. Affiliation:Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland.. ...

Read articles on genomic research from current developments to experiments and developments. Written in an easy to read format by students, teachers and researchers all at BrightHubs Genetics Channel.

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HomePublic LibraryGeneral PublicationsScientific PaperA review on biosurfactants: Fermentation, current developments and perspectives ...

This thesis reports on the fabrication of a disposable bio-nano-chip (BNC), a microfluidic device composed of polydimethylsiloxane (PDMS) and thiolene-based optical epoxy which is both cost-effective and suitable for high performance immunoassays. A novel room temperature (RT) bonding technique was utilized so as to achieve irreversible covalent bonding between PDMS and thiolene-based epoxy layers, while at the same time being compatible with the insertion of agarose bead sensors, selectively arranged in an array of pyramidal microcavities replicated in the thiolene thin film layer. In the sealed device, the bead-supporting epoxy film is sandwiched between two PDMS layers comprising of fluidic injection and drain channels. The agarose bead sensors used in the device are sensitized with anti-C-reactive protein (CRP) antibody, and a fluorescent sandwich-type immunoassay was run to characterize the performance of this device. Computational fluid dynamics (CFD) was used based on the device ...

E.M.J. (Sabeth) Verpoorte has more than 26 years of research experience in the lab-on-a-chip field, starting in 1990 as a postdoctoral researcher and later as staff research scientist in the pioneering lab-on-a-chip group headed by Professor A. Manz at Ciba Ltd., Basel, Switzerland. In July 1996 she assumed the position of team leader in the group of Professor Nico F. de Rooij at the Institute of Microtechnology (IMT), University of Neuchâtel, Switzerland, where her research interests concentrated on the lab-on-a-chip area for bioanalytical and environmental applications. She successfully led a research team of 5 PhD students and 3 postdocs while at IMT.. Sabeth Verpoorte has been head of the Pharmaceutical Analysis Group in the Groningen Research Institute of Pharmacy, University of Groningen, since 2003. Research in the Pharmaceutical Analysis group is devoted to better understanding micro- and nanofluidic systems and how they can be applied to chemical and cell biological problems. A major ...

Imagine a small flat 3×1 square of clear glass. On top rests another piece of glass with small holes open to the square underneath.. Now imagine if a full-scale wet lab - complete with rows of flasks, tubes, pumps and a centrifuge - could fit on this miniature surface.. If youre Virginia Tech cancer researcher Iuliana Lazar, thats your goal.. This is the lab-on-a-chip concept, said Lazar, an associate professor of biological sciences in the College of Science. Essentially you have an entire lab shrunk down to a few square-inch chip. The plan is to integrate various functional [lab] elements by minimizing their size or developing new designs and new principles that will allow scientists to accomplish new experiments.. Recently her work was highlighted in an interview with International Innovation, a freely accessible journal which contacted Lazar last year.. This lab-on-a-chip technology will decrease the amount of time it takes to prep and study cells in a lab. It will also allow Lazar ...

Biofabrication and biomaterials for urinary tract reconstruction Moustafa M Elsawy,1-3 Achala de Mel1 1Division of Surgery and Interventional Science, Royal Free Hospital, NHS Trust, University College London (UCL), 2Division of Reconstructive Urology, University College London Hospitals (uclh), London, UK Abstract: Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patients autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials.

The ability to drive efficient micromixing on a microfluidic platform is crucial for a wide range of lab-on-a-chip applications. Here, we investigate the abilit

TY - JOUR. T1 - Microfabricated capped channels for biomolecular motor-based transport. AU - Huang, Ying Ming. AU - Uppalapati, Maruti. AU - Hancock, William O.. AU - Jackson, Thomas Nelson. PY - 2005/11/1. Y1 - 2005/11/1. N2 - Kinesins are molecular motors that transport intracellular cargo along microtubules and provide a model system for force generation that can be exploited for biomotor powered nano- and micro-machines. To use this biological system for microscale transport, the most common approach is to reverse the biological geometry and move microtubules along surfaces functionalized with kinesin motors. The microtubules then become potential transport vehicles for sensors and lab-on-a-chip applications. A key requirement for extracting useful work from this system is confinement and control of microtubule movements over kinesin-coated surfaces. The open channel approaches used to date are limited because microtubules that lose contact with the kinesin motors rapidly diffuse away. As a ...

The fruit fly or Drosophila melanogaster has been used as a promising model organism in genetics, developmental and behavioral studies as well as in the fields of neuroscience, pharmacology, and toxicology. Not only all the developmental stages of Drosophila, including embryonic, larval, and adulthood stages, have been used in experimental in vivo biology, but also the organs, tissues, and cells extracted from this model have found applications in in vitro assays. However, the manual manipulation, cellular investigation and behavioral phenotyping techniques utilized in conventional Drosophila-based in vivo and in vitro assays are mostly time-consuming, labor-intensive, and low in throughput. Moreover, stimulation of the organism with external biological, chemical, or physical signals requires precision in signal delivery, while quantification of neural and behavioral phenotypes necessitates optical and physical accessibility to Drosophila. Recently, microfluidic and lab-on-a-chip devices have ...

Coating the inside of glass microtubes with a polymer hydrogel material dramatically alters the way capillary forces draw water into the tiny structures, researchers have found. The discovery could provide a new way to control microfluidic systems, including popular lab-on-a-chip devices.

Introduction. The rapid and sensitive detection of hydrogen peroxide (H2O2) is a major area of interest within the fields of: environmental control, chemical and pharmaceutical industry as well as clinical diagnostics [1]. Different analytical techniques have been employed in order to detect H2O2, among the most widely used techniques are: UV-vis spectroscopy, chemiluminescence and titration methods [2, 3]. Despite these methods being effective in the detection of H2O2, the requirement of sample pretreatment, bulky instruments and longtime analysis open the space for new analytical methods where the detection could be done in a direct and faster way. Such new detection method offering direct sample analysis, faster response and possibility of miniaturization will accelerate the use of H2O2 detection on-site and its integration in for instance lab-on-a-chip devices.. Electrochemical biosensors based on plant peroxidases have attracted special attention due to their simplicity, rapidity, ...

Global Lab-on-a-chip (LOC) Market Size, Status and Forecast 2022 is a market research report available at US $3300 for a Single User PDF License from RnR Market Research Reports Library.

TY - JOUR. T1 - Corona discharge-induced functional surfaces of polycarbonate and cyclic olefins substrates. AU - Haq, Atta. AU - Boyd, A. AU - Acheson, Jonathan. AU - McLaughlin, James. AU - Meenan, BJ. PY - 2019/3/25. Y1 - 2019/3/25. N2 - Functional surfaces have great significance for improving the performance of bio-devices. The selection of appropriate ways to functionalise the surfaces of the polymers used for bio-devices are in great demand. In particular, cyclic olefin copolymer (COC) and cyclic olefin polymers (COP) are emerging substrates for bio-devices and possess superior chemical resistance than other polymeric substrates such as polycarbonate (PC). These polymer substrates often require surface modification to provide the functionality required. Here, we present a means to functionalise the surfaces of these polymers by a corona discharge treatment method. The water contact angle (WCA) of as received PC, COC and COP was found to be around 80° 96° and 93° respectively. The WCA ...

Acid-catalyzed positive photoresist compositions which are imageable with 193 nm radiation and are developable to form photoresist structures of high resolution and high etch resistance are enabled by the use of a combination of cyclic olefin polymer, photosensitive acid generator and a hydrophobic non-steroidal multi-alicyclic component containing plural acid labile linking groups. The cyclic olefin polymers preferably contain i) cyclic olefin units having polar functional moieties, ii) cyclic olefin units having acid labile moieties that inhibit solubility in aqueous alkaline solutions.

SlERILIZAliON AND SOCIAL WELFARE A Survey of Current Developments in North Carolina By MOYA WOODSIDE Institute for Research in Social Science, University of North Carolina Therapeutic sterilization may be defined as an opera-tion intended to benefit the health of the subject, whereas the purpose of eugenic sterilization is to prevent the transmission of diseases and defects to future generations. In everyday practice, apart from certain grave mental disorders or some urgent physical indications for the procedure, we find that the two categories are not sharply contrasted but tend to shade into each other at different points on a scale; and this overlapping is especially noticeable in cases from those lower-income groups which come within the purview of State agencies. We may cite, for example, the multipara of borderline mentality, who is as likely to require relief from further pregnancies on the physical grounds of exhaustion, cardio-vascular symptoms of pelvic damage as she is on grounds of ...

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TY - GEN. T1 - Holographic control of droplet microfluidics. AU - Cordero, Maria-Luisa. AU - Burnham, Daniel R.. AU - Baroud, Charles N.. AU - McGloin, David. PY - 2008. Y1 - 2008. N2 - Droplet microfluidics is an emerging area in miniaturisation of chemical and biological assays, or lab-on-a-chip devices. Normally consisting of droplets flowing in rigid microfluidic channels they offer many advantages over conventional microfluidic design but lack any form of active control over the droplets. We present work, using holographic beam shaping, that allows the real time reconfigurability of microfluidic channels allowing us to redirect, slow, stop, and merge droplets with diameters of approximately 200 microns. A single beam is be sufficient to perform simple tasks on the droplets but by using holographic beam shaping we can produce multiple foci or continuous patterns of light that enable a far more versatile tool.. AB - Droplet microfluidics is an emerging area in miniaturisation of chemical ...

The 3Rs-Centre Utrecht Life Sciences published an article about our research-driven Masters programme Biofabrication. The two-year programme is the first in the world in which students will study the technology involved in creating tissue, including 3D bioprinting. The master will accelerate the development of non-animal models in biomedical research.. Read the 3Rs-Center Utrecht life Sciences Newsletter #73 October for the full article.. ...

A biofabrication team from the Queensland University of Technology in Brisbane, Australia has made a major breakthrough by successfully 3D printing mechanically reinforced, tissue-engineered constructs for the regeneration of body parts.

The flagship monthly journal of SPIE, |i|Optical Engineering|/i| (OE) publishes peer-reviewed papers reporting on research and development in all areas of optics, photonics, and imaging science and engineering.

The aim here is the fabrication and characterization of nanostructured thin films of different materials inside microchannels to assist the integration process of electronic tongue in lab-on-a-chip devices. The ultrathin films were deposited inside the microchannels using dynamic layer-by-layer technique through copper (II) tetrasulphonated phthalocyanine (CuTsPc) and poly(allylamine hydrochloride) (PAH) bilayers, and also bilayers of poly(3,4-ethylenedioxythiophene) poly(syterenesulfonate) (PEDOT:PSS) and PAH. It was verified the best parameters involved in the nanostructuration of the materials throughout flow and time variations of the deposition of the electrolytes inside the microchannel. Moreover, the growth of the LbL films inside the microchannel was followed by UV-vis and impedance spectroscopy measurements. Through electrical impedance spectroscopy technique was observable that deposition of thin films PAH/CuTsPc was successful using a time of 8 min with a flow of 1500 μL/h, while ...

SUBMITTED BY ARTHUR N1ORC - AMSAT A/C #31468 Crabs Give Blood for Space Travel 11.16.2006 Soon, astronauts onboard the ISS will test a high-tech medical device that uses primitive enzymes from horseshoe crabs to diagnose human illness. Nov. 16, 2006: Picture this: Youre on a mission to Mars, halfway there from Earth, and youre not feeling well. Your throat hurts when you swallow, your forehead is hot. You dont want to get sick or infect your crewmates. Should you take an antibiotic? If so, which kind? With a new biological laboratory on a chip being developed at NASAs Marshall Space Flight Center in Huntsville, Alabama, in partnership with outside researchers, you may be able to get the answer in as little as five minutes. The mini-lab goes by the maxi-acronym LOCAD-PTS, which stands for Lab-On-a-Chip Application Development Portable Test System. The latest version is a handheld device slated for launch this December aboard shuttle mission STS-116 for testing on the International Space ...

Researchers at the California Institute of Technology have demonstrated a method for using a so-called lab-on-a-chip device and a mobile phone to determine the concentration of molecules, such as viral RNA molecules, in a sample. This digital approach can provide accurate quantitative information despite changes in timing, temperature and lighting conditions, a capability not previously possible using traditional instrumentation. The work published in the journal Analytical Chemistry points the way towards digital diagnostics for a wide range of illness and health problems.. ...

minoHealth, a Ghanaian startup in AI Labs, in partnership with Imperial College London, has won the UK Research and Innovation (UKRI) Digital Innovation for Development in Africa (DIDA) Grant of up to £150,000.. The network, with partners across the U.K. and Africa, is also eligible for a-£3 million grant for research, development and implementation, on reaching the second stage of the programme.. The networks project, initiated by Imperial College London, is the Lacewing-handheld digital molecular diagnostic device and platform.. Lacewing is a lab-on-a-chip device that allows for rapid diagnosis of infectious diseases, like malaria, with results comparable to Polymerase Chain Reaction (PCR). It has already been adapted to COVID-19.. Mr Darlington Akogo, the Executive Director and Founder of minoHealth AI Labs, told the Ghana News Agency that the objective of the project is to test, improve and deploy the system especially in Africa, in the fight against Malaria and other infectious ...

Assessment of a tumors molecular makeup using biofluid samples, known as liquid biopsy, is a prominent research topic in precision medicine for cancer, due to its noninvasive property allowing repeat sampling for monitoring molecular changes of tumors over time. Circulating exosomes recently have been recognized as promising tumor surrogates because they deliver enriched biomarkers, such as proteins, RNAs, and DNA. However, purification and characterization of these exosomes are technically challenging. Microfluidic lab-on-a-chip technology effectively addresses these challenges owing to its inherent advantages in integration and automation of multiple functional modules, enhancing sensing performance, and expediting analysis processes. In this article, we review the state-of-the-art development of microfluidic technologies for exosome isolation and molecular characterization with emphasis on their applications toward liquid biopsy-based analysis of cancer. Finally, we share our perspectives on ...

TY - CHAP. T1 - The sonic screwdriver. T2 - a model system for study of wave angular momentum. AU - Spalding,Gabriel C.. AU - Volovick,Alex. AU - Yang,Zhengyi. AU - Démoré,Christine. AU - MacDonald,Michael P.. AU - Cochran,Sandy. PY - 2011. Y1 - 2011. N2 - When samples of interest are small enough, even the relatively weak forces and torques associated with light can be sufficient for mechanical manipulation, can offer extraordinary position control, and can measure interactions with resolution three orders of magnitude better than atomic force microscopy. However, as the components of interest grow to slightly larger length scales (which may yet be of interest for microfluidic, lab-on-a-chip technologies and for research involving biomedical imaging), other approaches gain strength. This paper includes discussion of the angular momentum carried by sonic beams that we have implemented both to levitate and controllably rotate disks as large as four inches across. Discussion of such acoustic ...

An olefin copolymer having a functional group and having a structural unit (a) derived from ethylene, a structural unit (b) derived from an α-olefin having 3 to 12 carbon atoms, and a structural unit (c) derived from a cycloolefin, exhibits an intrinsic viscosity [η] of 0.1 to 10 dl/g as measured in decalin at 135 C. and can be used in a rubber composition.

This review provides a clear overview of the state-of-the-art of flame retardancy for plastics. It highlights the new developments and the potential problems with legislation, together with the benefits to end users of protection from fire hazards. This review is accompanied by around 400 abstracts from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject. A subject index and a company index are included.

This review provides a clear overview of the state-of-the-art of flame retardancy for plastics. It highlights the new developments and the potential problems with legislation, together with the benefits to end users of protection from fire hazards. This review is accompanied by around 400 abstracts from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject. A subject index and a company index are included.

In this review we present the current stage and developments in the finite element modeling of mass transport by the smeared concept, introduced and conducted by the first author over several years....

Despite plaguing humans for thousands of years, tuberculosis remains a widespread and lethal public health problem throughout the world today. The recent rise of multi-drug-resistant tuberculosis (MDR-TB) perpetuates the public health threat while presenting a potential bioterrorism agent. The BCG vaccine is the only available prevention against TB, yet it elicits inconsistent protection when given to infants, fails to provide consistent protection in adults against pulmonary disease, and is unsafe for use in immunocompromised patients. A new crop of TB vaccine candidates has entered into clinical trials, with a second generation following shortly. These new TB vaccines are hoped to provide a safe, efficacious replacement, or addition to, the nearly century-old BCG and provide protection against TB disease beyond childhood. This review details the status of the most promising TB vaccine candidates in development, as one of these candidates may play a key role in defending against an ominous ...

Dual antiplatelet therapy (DAPT) with acetylsalicylic acid and an inhibitor of the adenosine diphosphate platelet receptor P2Y12 has been shown to reduce the risk of stent thrombosis (ST), myocardial infarction and cardiac death after percutaneous coronary intervention (PCI) with bare-metal stents (BMS) and drug-eluting stents (DES). However, while there is consensus on 1-month DAPT after BMS, the optimal duration and the risk-benefit ratio of DAPT duration after DES implantation remains controversial. Controversy surrounding this issue is demonstrated by differences in guideline recommendations for DAPT duration after PCI with DES. For example, while the ACC/AHA recommends a minimum of 12 months, ESC guidelines recommend at least 6 months of DAPT. Recent reports suggest that 6 months of DAPT after second-generation DES implantation might be safe compared with longer durations. Large randomized controlled trials powered to examine ST and bleeding events are currently ongoing and will shed novel ...

ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...

In apparent contradiction, the stiffness of heart cells was reported to increase with frequency (Shroff et al., 1995). This discrepancy can be explained by instrumental differences. In Shroff et al.s work, a cover slip with attached cells was vibrated in the z direction by a piezoelectric stage so that there was no drag between the cells and the media. The stiffness of the heart cells measured by AFM was in the range of 0.1 N/m at 100 Hz (Shroff et al., 1995). If we assume that Shroff et al.s figures apply to our cells, a 0.01 N/m cantilever would have underestimated the true movement by ∼15%.. The molecular nature of the membrane motor is not yet clear. As the applied voltage drops mainly across the membrane, the electromechanical transduction must be located in the cell membrane. One possibility is that membrane proteins, whose dipoles are not oriented parallel to the imposed field, reorient in the field. However, to obtain movements of 5 nm requires that the proteins extend far from the ...

A series of studies aimed at developing methods and systems of analyzing epigenetic information in cells and in cell networks, as well as that of genetic information, was examined to expand our understanding of how living systems are determined. Because cells are minimum units reflecting epigenetic information, which is considered to map the history of a parallel-processing recurrent network of biochemical reactions, their behaviors cannot be explained by considering only conventional DNA information-processing events. The role of epigenetic information on cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behaviour observed under conditions chosen to reveal adaptation processes, population effects and community effects. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an

Ok, so I will stop sending you these messages … if you do one last favor for me (for all of us)!! Tell your friends and colleagues who work in these areas: regenerative medicine organ-on-a-chip tissue engineering tissue and organ printing pre-clinical drug safety testing drug activity screening 3D bioprinting personalized oncology diagnostic testing tissue…

Rapid biosynthesis of silver nanoparticles from Gram +ve and Gram -ve bacterial strains and their hiogenicity dependent antibacterial and cytntoxicity.

Corning Incorporated (NYSE: GLW) today announced its new Corning® 96- and 384-Well Spheroid Microplates and the Corning® High-Content Imaging Cyclic Olefin Copolymer (COC) Microplates. Corning Life Sciences will showcase its latest innovations in booth #1029 at the Society for Laboratory Automation & Screening (SLAS) 2014 Conference, Jan. 18-22, in San Diego, Calif.

Corning Incorporated (NYSE: GLW) today announced its new Corning® 96- and 384-Well Spheroid Microplates and the Corning® High-Content Imaging Cyclic Olefin Copolymer (COC) Microplates. Corning Life Sciences will showcase its latest innovations in booth #1029 at the Society for Laboratory Automation & Screening (SLAS) 2014 Conference, Jan. 18-22, in San Diego, Calif.

Turbulence is commonly viewed as a type of macroflow, where the Reynolds number (Re) has to be sufficiently high. In microfluidics, when Re is below or on the order of 1 and fast mixing is required, so far only chaotic flow has been reported to enhance mixing based on previous publications since turbulence is believed not to be possible to generate in such a low Re microflow. There is even a lack of velocimeter that can measure turbulence in microchannels. In this work, we report a direct observation of the existence of turbulence in microfluidics with Re on the order of 1 in a pressure driven flow under electrokinetic forcing using a novel velocimeter having ultrahigh spatiotemporal resolution. The work could provide a new method to control flow and transport phenomena in lab-on-a-chip and a new perspective on turbulence.

Acoustofluidics has become a well-established technology in the lab-on-a-chip scientific community. The technology involves primarily the manipulation of fluids and/or particles in microfluidic systems. It is used today for variety of applications such as handling, sorting, washing and separation of cells or micro-particles, and for mixing and pumping of fluids. When such manipulation functions are integrated in micro-devices, the technology has been used for clinical sample preparation as well as for studying various fundamental bio-related questions.. In this doctoral thesis, we have developed different acoustic methods and micro-devices with the aim to create a multi-functional sample preparation platform. We introduced a simple method for in-situ measurements of acoustic energy densities inside a microfluidic channel, from which acoustic pressure amplitudes can be extracted. The method has been used for determining the magnitude of acoustic radiation forces acting on suspended particles and ...

MicruX is focused on the design, development and manufacture of novel miniaturized analytical systems based on Lab-on-a-Chip, microfluidics and electrochemistry.

Shih and his team developed DMF technology that can automate the synthetic biology process of design-build-test-learn. Digital microfluidics involves miniaturized lab-on-a-chip devices.. Normally the size of a credit card, they are used to integrate several laboratory functions onto a single chip as small as a few nanolitres of fluid. By manipulating very small volumes of fluid on electrodes using voltage, we have a powerful tool that allows us to perform several medical tests in one shot, and address challenging problems in health care, says the founder of the Shih Microfluidics Laboratory.. Our device will radically speed up lab analysis and research.. Cancer research is one example of how DMF technology can be applied. Researchers can take a sample of cells - usually a tiny droplet of cells that researchers believe are going to help us understand cancer better - and put them directly on the DMF device with an array of electrodes.. Trying to obtain cells related to diseases like ...

Incorporating biotechnology with microfluidic makes a manipulation of very small volume of biological fluid not only feasible, but also effective especially by means of electrophoresis. Recent research and development efforts have been focused on inventing an electrophoretic microsystem that is fully automated, easy to customize for a specific need, and provides the results consistent with the gold standard. This microfluidic microsystem is usually referred to as a lab-on-a-chip. Among the microfluidic microsystems used in the analytical (bio)chemistry, the most widely used methods to control the transport of biomolecules or analytes are either gel or capillary electrophoresis.. Even though both techniques utilize the fact that biomolecules such as proteins, peptides, and DNA become charged in a buffer, the microfluidic gel electrophoresis operates differently from its capillary counterpart in terms of fluid dynamic. In microfluidic gel electrophoresis, the presence of porous gel medium prevents ...

CHE5SEA is a required subject for Bachelor of Science (Honour)/Master of Nanotechnology students. You will study contemporary theoretical and technological aspects of chemical sensors and biosensors, as well as the chemical materials required for real world implementation. This multifaceted subject includes topics on sensors and electrochemistry (electrochemical principles, general concepts of chemical sensing, amperometric sensors, lab-on-a-chip miniaturization), surface chemistry(the role of second order interactions and the chemical potential in chemical processes, solubility, miscibility, solvent extraction, interactions on and between surfaces and interfaces with implications in catalysis and sensing) and polymer chemistry (concepts, nomenclature, synthesis and characterisation of polymers and their real world applications). You will gain experience conducting and interpreting laboratory experiments related to sensors and materials chemistry. ...

Sepsis, commonly referred to as blood poisoning, is a serious medical condition characterized by a whole-body inflammatory state caused by microbial infection. Rapid treatment is crucial, however, traditional culture-based diagnostics usually takes 2-5 days. The overall aim of the thesis is to develop microfluidic based sample preparation strategies, capable of isolating bacteria from whole blood for rapid sepsis diagnostics. Although emerging technologies, such as microfluidics and lab-on-a-chip (LOC) devices have the potential to spur the development of protocols and affordable instruments, most often sample preparation is performed manually with procedures that involve handling steps prone to introducing artifacts, require skilled technicians and well-equipped, expensive laboratories. Here, we propose the development of methods for fast and efficient sample preparation that can isolate bacteria from whole blood by using microfluidic techniques with potential to be incorporated in LOC ...

Lehigh University engineers, Xuanhong Cheng and James Hwang, awarded National Science Foundation grant to explore the use of microwave technology to characterize the nucleus of a live cell captured on a lab-on-a-chip microfluidic device.