TY - JOUR. T1 - Diagnostic utility of SATB2 in metastatic krukenberg tumors of the ovary. T2 - An immunohistochemical study of 70 cases with comparison to CDX2, CK7, CK20, Chromogranin, and synaptophysin. AU - Yang, Chen. AU - Sun, Li. AU - Zhang, Lingxin. AU - Zhou, Lixin. AU - Zhao, Ming. AU - Peng, Yan. AU - Niu, Dongfeng. AU - Li, Zhongwu. AU - Huang, Xiaozheng. AU - Kang, Qiang. AU - Jia, Lin. AU - Lai, Jinping. AU - Cao, Dengfeng. PY - 2018/1/1. Y1 - 2018/1/1. N2 - SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess its diagnostic utility. We also compared SATB2 with CDX2, ...

The Krukenberg procedure, also known as the Krukenberg operation, is a surgical technique that converts a forearm stump into a pincer. It was first described in 1917 by the German army surgeon Hermann Krukenberg. It remains in use today for certain special cases but is considered controversial and some surgeons refuse to perform it. The procedure involves separating the ulna and radius for below-elbow amputations, and in cases of congenital absence of the hand, to provide a pincerlike grasp that is motored by the pronator teres muscle. The prerequisites for the operation are a stump over 10 cm long from the tip of the olecranon, no elbow contracture, and good psychological preparation and acceptance. The success of the Krukenberg procedure depends directly on the strength of the pronator teres, the sensibility of the skin surrounding both ulna and radius, elbow mobility, and mobility of the ulna and radius at the proximal radioulnar joint. Individual patient expectations and motivations, ...

Journal of Oncology Research and Therapy is a high-impact, peer-reviewed medical journal that publishes important clinical oncology research along with articles, reviews and discusses the latest research innovations and important developments in this field.

Krukenbergs tumours are metastatic tumours of the ovary. The colon and stomach are the most common primary tumour sites. Breast, lung, and pancreas are the other sites of metastasis. These tumours constitute 5-10% of ovarian neoplasms.. The differential diagnosis from a primary ovarian tumour is very important for therapeutic approach. Krukenbergs tumours are bilateral in 60-80% of cases. Therefore whenever bilateral ovarian involvement is detected, a search for a primary site, especially in the gastrointestinal system, should be carried out. In contrast to primary ovarian tumours, the ovaries keep their shape in Krukenbergs tumour. Some other radiological findings give important clues. Early in the development of these tumours, the solid component is most prominent, as seen in this case. At US Krukenberg tumor typically present as bilateral, solid ovarian masses, with clear well defined margins. An irregular hyperechoic solid pattern and moth eaten like cyst formation are also ...

Tragically, land mines injure between 15,000 and 20,000 people each year. Some civilians see a metal object sticking out of the ground and attempt to pick it up and inspect it -- the result is often loss of both hands and eyes.. The goal of rehabilitation after trauma is to restore as much independence as possible to patients. With loss of vision and no hands, self care, feeding, and donning/doffing arm prostheses can be very challenging. There is a procedure, known as the Krukenberg operation (named after Hermann Von Krukenberg, who first described it in 1917), that allows the forearm bones to be separated, using the muscle rotators that exist between them to create a pincer grasp. This procedure is not uncommonly used in India and Pakistan and does indeed return some degree of functional use to the arms.. At a recent Physical Medicine and Rehabilitation conference, this photograph was used to illustrate arm function after the Krukenberg operation. ...

INTRODUCTION. In 1896 Krukenberg (1) described an unusual form of an ovarian metastasis by a gastrointestinal cancer. The analogue in male, a metastasis to the testis or epididymis by a primitive gastric cancer is extremely rare. We report an unusual metastasis to the testis and epididymis, which has all criteria to be called Krukenberg-tumor.. CASE REPORT. W.A., a 68 years old patient, was submitted to total gastrectomy in 1994. Histologically it was described a diffuse, poorly differentiated gastric adenocarcinoma with multiple lymph node metastases along the greater and lesser gastric curvature and an isolated lymph node metastasis in the splenic hilum (TNM stage: pT3 GIII N+ M1).. One year later the patient developed a light painful swelling of the right hemiscrotum and groin. The palpation revealed a painful mandarine-like mass conglobated in the right testis and epididymis, which seemed to be connected with a further mass, about as big as a chestnut, at the external inguinal-ring. Multiple ...

El tumor de Krukenberg (TK) se define como un adenocarcinoma metastásico bilateral de ovario que contiene células en anillo de sello productoras de mucina. Comprende 1-2% de las neoplasias ováricas; su edad promedio es ...

9(60%) patients had certain symptoms like abdominal pain or distention on the detection of ovarian tumor, while 6(40%) had no symptoms. Metachronous ovarian metastasis occurred in 7(46.7%) and synchronous metatsis in 8(53.3%) patients. The median period between primary tumor resection and oophorectomy in the patients with metachronous ovarian metastasis was 14 months (8-36 months). Combined metastases occurred in 10 patients (66.7%), including peritoneal metastasis in 7 of the patients and liver metastasis in 5. Bilateral ovarian metastasis was found in 7 patients (46.7%). The median ovarian metastasis tumor size was 10 cm. The regions of primary tumor were on the sigmoid colon in 6 patients, the rectum in 5, the ascending colon in 2 and the transverse colon in 2. As the pathological features of primary tumor, a well-differentiated type and a moderately differentiated type were seen in 13 (86.7%), subserosa or deeper invasion were seen in all patients (100%) and lymph-node metastasis was seen in ...

A new approach for the evaluation of the severity of coarctation of the aorta using Doppler velocity index and effective orifice area: In vitro validation and clinical implications Academic Article ...

Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study

This is a case report of a 33-year-old woman who presented 5 days post-partum with abdominal distension, abdominal discomfort, increased bladder pressure and fatigue. These symptoms prompted a pelvic ultrasound and CT scan of the chest, abdomen and pelvis which showed a large 20 cm left-sided adnexal mass. Following this imaging, blood tests revealed elevated tumour markers CA-125 and lactate dehydrogenase, resulting in referral to and surgical intervention by the gynaecology oncology team. Pathology and immunohistochemistry indicated that the tumour was a metastasis from the colon, that prompted for colonoscopy which confirmed that the carcinoma was a metastases from the sigmoid.. ...

Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation (removal) of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed. Subsequent studies highlighted that the uveal melanoma showed high microsatellite instability and loss of MLH1 and PMS2 protein expression, with no MLH1 promoter methylation or BRAF mutation. Additionally, a GNAQ mutation was found. We conclude that our patients uveal melanoma is most likely related to MLH1 germline mutation and thus Lynch syndrome related. To the ...

Meningeal Carcinomatosis; Carcinomatous Meningitis. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

We studied a new cellular model for Blooms syndrome consisting of HeLa cells constitutively expressing a shRNA specific for BLM and transiently transfected with a pool of siRNAs directed against sequences other than that targeted by shBLM. These cells display the growth defect, cytogenetic features (high levels of SCE), and mitotic abnormalities (anaphase bridges and lagging chromosomes) typical of Blooms syndrome cells.. We found that SCE formation in response to BLM depletion was strictly dependent on RAD51, showing an epistatic interaction between the two genes. In mammalian cells, RAD51 involvement has been reported in the formation of induced, but not spontaneous, SCEs (32), suggesting that the SCEs in Blooms syndrome cells are induced. Thus, the constitutively high levels of RAD51-mediated SCEs in Blooms syndrome cells are probably induced by the decrease in fork velocity in these cells, which may render them susceptible to DNA breaks (33, 34). RAD51 would then be recruited to the ...

Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.

Evaluation of Gallbladder Adenocarcinoma by Next Generation Sequencing Reveals Frequent Actionable Genomic Abnormalities and New Routes to Targeted Therapies

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Free Shipping and Free Returns on Le Labo Liquid Balm - Patchouli 24 at www.barneys.com. The liquid balm is a new way to carry your signature scent anywhere.

The case of adenocarcinoma with human chorionic gonadtropin (HCG), primary in the male gallbladder, is extremely rare. A Medline search has shown only a few similar cases reported. We herein describe a case of primary gallbladder adenocarcinoma associated by ectopic HCG positive tumor cells in a 79-year-old male. Pathological examination showed a mixture of moderately and poorly differentiated adenocarcinoma with ectopic HCG and placental alkaline phosphatase (PlAP) in tumor cells, though the increase of serum or urinary HCG secretion was not confirmed. The literatures were also reviewed. A case of gallbladder cancer with ectopic HCG production is quite rare in the literature, though many similar cases in other site, especially in GI tract, are reported. Embryological consideration suggests the increased frequency of similar cases more than being thought now.

Background and purposeCerebral hyperperfusion has been related to the risk of intracranial hemorrhage (ICH) in stroke patients after vessel recanalization therapy. We hypothesized that after successful mechanical thrombectomy for acute a ...

Abstract:. Cutaneous metastasis is a rare manifestation of visceral malignancies, a phenomenon seen in 1% to 3% of all metastasizing tumors. A 62 years old female presented with multiple skin nodules in the neck and jaundice for 2 months. FNAC from the skin nodules revealed hypercellular smear composed of malignant epithelial cells arranged in clusters and glandular patterns. A provisional diagnosis of metastatic adenocarcinoma was given. USG and CT-scan of abdomen revealed a tumor in gallbladder fossa. USG guided FNAC and later on histopathological examination from the biopsy of the gallbladder tumor clinched the diagnosis of moderately differentiated gallbladder adenocarcinoma. Biopsy from the skin nodules revealed adenocarcinoma metastasis in skin. The patient was given postoperative chemotherapy and radiotherapy. Follow up period (3 months) was eventful.. ...

Epithelial ovarian cancer (EOC) is a devastating disease that affects 1 in 72 women in the United States. It is the fourth leading cause of cancer-related deaths among women in the United States and is the primary cause of all gynecologic cancer-related deaths worldwide. Approximately 70% of patients diagnosed with EOC present with stage III or IV disease in which the tumor has disseminated beyond the ovaries and pelvic organs to the peritoneum and mesothelial lining of abdominal organs, including the diaphragm, stomach, omentum, liver, and intestines. Despite current surgical and cytotoxic therapies, 80% of patients diagnosed with advanced EOC develop recurrent disease and only 30% of patients survive 5 years after diagnosis (1). These findings underscore that tumor metastasis remains a major clinical challenge in the treatment of EOC. Thus, the identification of molecular targets regulating ovarian metastasis is critical for the development of more effective therapeutic agents for the ...

I dont think this really needs much of a comment from me... J Med Case Rep. 2015 Nov 17;9(1):264. Acute psychosis as an initial manifestation of hypothyroidism: a case report. Ueno S1, Tsuboi S...

Differential diagnosis of ovarian cystadenofibromas should include stromal ovarian tumors with fibrous component, struma ovarri, ovarian metastases and endometriomas. Ovarian tumors with fibrous parts, including fibroma, fibrothecoma and Brenner tumor often present with a predominantly solid component of low signal intensity on T2-weighted images [7, 11, 12]. Struma ovarri has been described as multilocular ovarian mass, with variable signal intensity of the cystic parts and coexistence of hypointense areas on T2-weighted images, due to the presence of viscous colloid material [15, 16]. Ovarian metastases with a rich fibrous component, usually originating from the gastrointestinal tract often have areas of low signal intensity on T2-weighted images and display strong enhancement after contrast material administration [17 ...