TY - JOUR. T1 - Overcoming immunological barriers to living donor kidney transplantation at Stanford University Medical Center. AU - Ladner, Daniela Patricia. AU - Busque, Stephan. AU - Melcher, Marc Lee. PY - 2008/4/10. Y1 - 2008/4/10. N2 - Aims: The outcome of living donor kidney transplantation (LDKT) is better than the outcome of deceased kidney transplantation, and the deceased donor pool has been slow to expand. Although recipients may have willing and healthy donors, immunological barriers can still prevent successful kidney transplantation. Therefore, we studied kidney transplant candidates at our institution with incompatible living donors to understand the barriers to LDKT and to develop strategies to overcome them. Methods: We identified candidates in our programme who have potential donors that have been rejected either because of ABO incompatibility or because of a positive cross-match. Age, blood type, panel reactive antibody (PRA), donor blood type, donor age and cross-match ...

TY - JOUR. T1 - Unusual presentations of BK virus infections in pediatric renal transplant recipients. AU - Drake, Keri A.. AU - Najera, Lydia. AU - Reed, Robyn C.. AU - Verghese, Priya S.. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2013/2. Y1 - 2013/2. N2 - BKV has emerged as a significant pathogen in the field of transplantation, predominantly causing BKV nephropathy in renal transplant recipients and hemorrhagic cystitis in HSCT recipients. However, case reports describe more diverse complications, and we too present three unusual cases of BKV infections in pediatric renal transplant recipients. First, we describe a case of biopsy-proven renal damage secondary to BKV prior to the onset of viremia, demonstrating that BKV nephropathy can occur without preceding viremia. We also present two renal transplant recipients with persistent BK viruria, one with BKV-associated hemorrhagic cystitis and the other with microscopic hematuria. Therefore, we conclude that BKV ...

TY - JOUR. T1 - Posttransplant diabetes mellitus in pediatric renal transplant recipients. T2 - A report of The North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). AU - Al-Uzri, Amira. AU - Stablein, Donald M.. AU - Cohn, Richard A.. PY - 2001/9/27. Y1 - 2001/9/27. N2 - Background. The incidence of renal post transplant diabetes mellitus (PTDM) in adults varies from 3-46%. Methods. We did a retrospective analysis of 1365 children in The North American Pediatric Renal Transplant Cooperative Study with renal transplant (Tx) reported between January 92 and July 1997. PTDM, defined as ,2 weeks of insulin therapy after Tx, developed in 36 patients. A control group of 153/1329 non-PTDM patients was selected and matched for age at Tx and primary diagnosis. Results. African-Americans were overrepresented (36.1 vs. 17.6%, P=0.017) and Hispanics were underrepresented (5.6 vs. 26.1%, P=0.019) among cases. Although prednisone dose 30 days post-Tx was higher among cases (0.89 mg/kg/day) ...

Purpose To determine the impact of transplant nephrectomy on morbidity and mortality and HLA immunization. Methods All patients who underwent transplant nephrectomy in our centre between 2000 and 2016 were included in this study. A total of 2822 renal transplantations and 180 transplant nephrectomies were performed during this period. Results The indications for transplant nephrectomy were graft intolerance syndrome: 47.2%, sepsis: 22.2%, vascular thrombosis: 15.5%, tumour: 8.3% and other 6.8%. Transplant nephrectomies were performed via an intracapsular approach in 61.7% of cases. The blood transfusion rate was 50%, the morbidity rate was 38% and the mortality rate was 3%. Transplant nephrectomies more than 12 months after renal transplant failure were associated with more complications (p = 0.006). Transfusions in the context of transplant nephrectomy had no significant impact on alloimmunization. Conclusion The risk of bleeding, and therefore of transfusion, constitutes the major challenge of this

TY - JOUR. T1 - Non-immunological risk factors associated with chronic allograft nephropathy following kidney transplantation. AU - Shiroki, Ryoichi. AU - Hoshinaga, Kiyotaka. PY - 2002/11/1. Y1 - 2002/11/1. N2 - Although the precise mechanisms are unclear, not only alloantigen-dependent but also antigen-independent factors are generally thought to influence the development of chronic allograft nephropathy (CAN). Among the non-immunological determinants, there are various factors related with donor, recipient and graft procurement. As donor factors, age and cause of death were demonstrated to be significantly independent in long-term graft survival of cadaveric kidney transplantation. Grafts from aged donors and from donors with athelosclerosis showed poor prognosis on graft survival. Regarding recipient factors, cardiovascular complications, as hypertension and hyperlipidemia, were responsible for graft as well as patient survival. In addition, CMV infection and drug nephrotoxicity were also ...

Five patients who were recently recovered from Covid 19 underwent successful Kidney transplantation at VPS Lakeshore hospital. After the surgeries, all the patients are doing well.

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Renal transplant recipients often suffer from dyslipidemia which is one of the principal risk factors for cardiovascular disease. This study sought to determine characteristics of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and their associations with carotid intima-media thickness (cIMT) in a group of pediatric renal transplant recipients. We also examined the influence of immunosuppressive therapy on measured LDL and HDL particle characteristics. HDL size and subclass distribution were determined using gradient gel electrophoresis, while concentrations of small, dense LDL (sdLDL)-cholesterol (sdLDL-C) and sdLDL-apolipoprotein B (sdLDL-apoB) using heparin-magnesium precipitation method in 21 renal transplant recipients and 32 controls. Renal transplant recipients had less HDL 2b (P lt 0.001), but more HDL 3a (P lt 0.01) and 3b (P lt 0.001) subclasses. They also had increased sdLDL-C (P lt 0.01) and sdLDL-apoB (P lt 0.05) levels. The proportion ...of the HDL 3b ...

Advanced chronic kidney disease often results in adverse cardiovascular outcomes and is the leading cause of mortality in patients with end stage renal diseases (ESRD). There is much information about the effect of chronic kidney diseases (CKD) on the left ventricle (LV) chamber, but the right ventricle (RV) as a neglected chamber had not been evaluated precisely, in spite of its importance. The aim of this study was to evaluate the impact of successful kidney transplants on the RV systolic and diastolic function using the advanced method of 2D speckle tracking echocardiography and comparison with the conventional methods. The study included 48 patients with CKD who were eligible for kidney transplantation and underwent successful kidney transplantations. Right ventricular indices were evaluated, while RV function was focused by conventional methods and 2D speckle tracking echocardiography before the successful kidney transplant and 1 week, 1 month, and 3 months after the successful kidney transplant.

TY - JOUR. T1 - Effect of kidney transplantation on outcomes among patients with hepatitis C. AU - Roth, David. AU - Gaynor, Jeffrey J.. AU - Reddy, K. Rajender. AU - Ciancio, Gaetano. AU - Sageshima, Junichiro. AU - Kupin, Warren. AU - Guerra, Giselle. AU - Chen, Linda. AU - Burke, George W.. PY - 2011/6. Y1 - 2011/6. N2 - The long-term outcome of kidney transplantation in patients infected with hepatitis C virus (HCV) and end stage renal disease (ESRD) is not well described. We retrospectively identified 230 HCV-infected patients using enzyme immunoassay and nucleic acid testing obtained during the transplant evaluation. Of 207 patients who had a liver biopsy before transplant, 44 underwent 51 follow-up liver biopsies at approximately 5-year intervals either while on the waitlist for a kidney or after kidney transplantation. Advanced fibrosis was present in 10% of patients biopsied, identifying a population that may warrant consideration for combined liver-kidney transplantation. Kidney ...

Introduction: The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA in patients with a stable creatinine remains unclear. Methods: We performed a retrospective cohort study of 103 patients receiving a first, kidney alone transplant between 12/1/2007 and 12/31/2013. Inclusion criteria were age ,18 years old at the time of transplant and at least two years of DSA monitoring. All patients underwent DSA screening every 3 months post-transplant with additional testing as clinically indicated. No treatment was given for DSAs in the absence of biopsy-proven rejection. Results: 20 patients (19%) developed dnDSA in the setting of a stable creatinine and 13 patients (13%) developed dnDSA in the setting of an elevated creatinine. Median follow-up time post-transplant was 4.1 (IQR 2.9-5.7) years. In a Cox ...

By B.DULGUUN. The first kidney transplant procedure in 1996 by Mongolian doctors was unsuccessful. After ten years, State Honored Doctor L.Jambaljav and his colleagues from the Mongolian National Central Hospital No.1 successfully conducted a kidney transplant procedure. Currently, State Honored Doctor and Professor of Chronic Kidney Disease Clinic D.Nyamsuren is working as the head of the Kidney Transplant Center team at the National Central Hospital. He has been working with the team since the introduction of kidney transplantation in Mongolia and saved 79 lives. Below is an interview with D.Nyamsuren about kidney transplantation in Mongolia.. -Whats the current actual cost of kidney transplantation?. -The National Central Hospital No.1 conducts kidney transplantation for 12 million MNT. Eight million is paid by the Ministry of Health package and the rest by the patient. At our current price, this budget is not sufficient. The National Central Hospital No.1 is able to transplant kidneys for ...

TY - JOUR. T1 - Longitudinal measurement of physical activity following kidney transplantation. AU - Dontje, Manon L.. AU - de Greef, Mathieu. AU - Krijnen, Wim. AU - Corpeleijn, Eva. AU - Kok, T. AU - Bakker, S.J.. AU - Stolk, Ronald P.. AU - van der Schans, Cees. PY - 2014. Y1 - 2014. N2 - Purpose of this longitudinal observational study was to (i) examine the change of daily physical activity in 28 adult kidney transplant recipients over the first 12 months following transplantation; and (ii) to examine the change in metabolic characteristics and renal function. Accelerometer-based daily physical activity and metabolic- and clinical characteristics were measured at six wk (T1), three months (T2), six months (T3) and 12 months (T4) following transplantation. Linear mixed effect analyses showed an increase in steps/d (T1 = 6326 ± 2906; T4 = 7562 ± 3785; F = 3.52; p = 0.02), but one yr after transplantation only 25% achieved the recommended 10 000 steps/d. There was no significant increase in ...

TY - JOUR. T1 - The interaction between post-transplant anemia and allograft function in kidney transplantation. T2 - The Japan Academic Consortium of Kidney Transplantation-II study. AU - The Japan Academic Consortium of Kidney Transplantation (JACK). AU - Okumi, Masayoshi. AU - Okabe, Yasuhiro. AU - Unagami, Kohei. AU - Kakuta, Yoichi. AU - Iizuka, Junpei. AU - Takagi, Toshio. AU - Shirakawa, Hiroki. AU - Shimizu, Tomokazu. AU - Omoto, Kazuya. AU - Ishida, Hideki. AU - Nakamura, Masafumi. AU - Tanabe, Kazunari. N1 - Funding Information: We appreciate the support from Katsunori Shimada, Ph.D. (STATZ Institute, Inc., Tokyo, Japan), who provided expert assistance with statistical analyses.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background: The interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation has not been evaluated directly. PTA, defined by WHO/AST criteria, was investigated in 1307 adult kidney transplant recipients between 2000 and 2015 (median ...

A three sequence, open-label, multi-center, prospective, study in stable kidney transplant patients to assess and compare the pharmacokinetics (Cmax, C24, and AUC), and safety of LCP-Tacro (tacrolimus) tablets versus Prograf (tacrolimus) capsules.. Stable kidney transplant patients who fulfill all I/E criteria will be enrolled and kept on Prograf for 7 days. Following a 24-hour PK study on Day 7 to determine pharmacokinetics for Prograf, all patients will be converted to once daily LCP-Tacro for 7 days with no dose changes allowed. On Day 14 and Day 21 a 24-hour LCP-Tacro PK study will be performed. On Day 22 patients will be converted back to their original twice daily dose of Prograf for a safety follow-up period of 30 days ending with a safety assessment on day 53. ...

Partial table of contents: A Short History of Renal Transplantation (R. Calne). Considerations in Organ Transplantation (R. Kerman). Pretransplantation and Posttransplantation Psychosocial Evaluation. (G. Wolff). Impact of Recipient Age on Renal Allograft Outcome (G. Arbus & D. Hebert). Steroid Withdrawal After Renal Transplantation (E. Ingulli & A. Tejani). Treatment of Acute Rejection (G. Offner). Urologic Complications in Renal Transplantation (O. Salvatierra). Noncompliance to Medical Regimens (B. Cole). Malignancy in Children (I. Penn). Long-Term Outcome of Kidney Transplantation in Children (D. Potter). Index.Pediatric Renal Transplantation, 1 was published 1994 under ISBN 9780471591207 and ISBN 0471591203. [read more] ...

PRIMARY OBJECTIVES:. I. To assess human papillomavirus (HPV) vaccine-type-specific seroconversion rates at 12-months post-transplantation among kidney transplant recipients who receive ,= 1 doses of the recombinant human papillomavirus nonavalent vaccine (Gardasil 9 HPV vaccine) ,= 30 days prior to transplantation.. SECONDARY OBJECTIVES:. I. To evaluate the following in adult kidney transplant recipients who receive ,= 1 doses of the Gardasil 9 HPV vaccine prior to transplantation:. Ia. HPV vaccine-type-specific seroconversion rates at 12-months post-transplantation.. Ib. Persistence and stability of HPV vaccine-type-specific geometric mean titers (GMT) at 6 and 12-months post-transplantation, and rise in HPV vaccine-type-specific GMT at the 13 month post-transplant visit.. Ic. Vaccine safety profile and allograft rejection/opportunistic infections stratified by number of vaccine doses and time between the last vaccine dose and the transplant procedure.. Id. HPV detection in self-collected ...

BACKGROUND: C-reactive protein (CRP) is a predictor of coronary heart disease, total mortality and chronic allograft nephropathy in renal transplant recipients. The determinants of CRP have been investigated in the general population, but not in renal transplant recipients. CRP might reflect metabolic aberrations in association with central obesity and systemic atherosclerosis. However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population. METHODS: Between August 2001 and July 2003, renal transplant recipients with a functioning graft for more than 1 year (n = 847) were eligible for investigation at their next visit to the outpatient clinic. A total of 606 patients (55% male, aged 51+/-12 years) participated at a median (interquartile range) time of 6.0 (2.6-11.4) years post-transplant. RESULTS: Median CRP concentration was 2.0 (0.80-4.8) mg/l and mean 24 h creatinine clearance was 62+/-22 ml

The ultimate goal of clinical transplantation is for the recipients to achieve long-term survival, with continuing graft function, that is equivalent to that of the age-matched general population. We studied subsequent outcome in kidney transplant recipients with 10 years of graft function. In all, 2202 kidney transplant recipients survived with graft function ,10 years. For 10-year survivors, the actuarial 25-year patient survival rate for primary transplant living donor (LD) recipients was 57%; graft survival, 43%. For primary transplant deceased donor (DD) recipients, the actuarial 25-year patient survival rate was 39%; graft survival, 27%. The two major causes of late graft loss were death (with graft function) and chronic allograft nephropathy (tubular atrophy and interstitial fibrosis). The two major causes of death with function were cardiovascular disease (CVD) and malignancy. For nondiabetic recipients, the mean age at death with function from CVD was 54 ± 13 years; for diabetic ...

PubMed journal article: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study. Download Prime PubMed App to iPhone, iPad, or Android

Uremia has long been recognized to disrupt the normal physiology of numerous organs, including the heart (2,3). Over the last 30 years, echocardiography studies have found adverse changes in cardiac structure and function associated with end-stage renal disease (ESRD), which is collectively termed uremic cardiomyopathy. These cardiac abnormalities, including left ventricular hypertrophy and systolic dysfunction, are common in hemodialysis and are associated with an increased risk of adverse clinical outcomes (4). However, the precise nature of the uremic mediators of cardiac dysfunction remain elusive. Kidney transplantation is the treatment of choice for selected patients with ESRD. A successful kidney transplantation improves the quality of life and reduces the mortality risk for most patients compared with maintenance dialysis (5). However, 50% to 60% of deaths among kidney transplantation recipients are directly attributable to cardiovascular disease. In addition, death from cardiovascular ...

TY - JOUR. T1 - Early renal function recovery and long-term graft survival in kidney transplantation. AU - Wan, Susan S.. AU - Cantarovich, Marcelo. AU - Mucsi, I.. AU - Baran, Dana. AU - Paraskevas, Steven. AU - Tchervenkov, Jean. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Following kidney transplantation (KTx), renal function improves gradually until a baseline eGFR is achieved. Whether or not a recipient achieves the best-predicted eGFR after KTx may have important implications for immediate patient management, as well as for long-term graft survival. The aim of this cohort study was to calculate the renal function recovery (RFR) based on recipient and donor eGFR and to evaluate the association between RFR and long-term death-censored graft failure (DCGF). We studied 790 KTx recipients between January 1990 and August 2014. The last donor SCr prior to organ procurement was used to estimate donor GFR. Recipient eGFR was calculated using the average of the best three SCr values observed during the first ...

TY - THES. T1 - Kidney transplantation from donors after cardiac death : studies on the pathophysiology and prevention of ischemic acute kidney injury and on the long-term outcome after transplantation. AU - Snoeijs, M.G.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - Kidney transplantation is the best treatment for patients with terminal kidney insufficiency, but due to a shortage of donor kidneys many people are deprived from this optimal care. Organ donation after a cardiac arrest can make the number of kidney transplantations rise and shorten or even eliminate the waiting list for kidney transplantations. However, because these donor kidneys are damaged by ischemia in the period between the cardiac arrest and organ preservation, there is a reticence to accept these donor kidneys. For this reason this dissertation closely studies the entire transplantation process from donor to receiver to find clinically usable methods that can prevent this primary non-function of donor kidneys after a cardiac arrest. ...

Kidney transplantation is worldwide considered the best replacement therapy in patients with end-stage renal disease. However, although impressive improvements in surgical techniques and in the management of immunosuppression, long-term results have not significantly changed over the last decades. The purpose of this book is not to be a comprehensive review on kidney transplantation, but it would overview the recent acquisitions in the field of kidney transplantation, by offering to clinicians the future directions and the possible fields of research to improve the long term outcome. The book is divided into 27 chapters. The first part of the book is devoted to the basic principles of immunity and organ transplantation and the clinical evaluation of potential recipient. Moreover, in this section are discussed the most recent strategies to increase the donor pool trying to offer a kidney transplantation to a growing number of patients. The second part of the book is devoted to the ...

The Banff Classification is a schema for nomenclature and classification of renal allograft pathology, established in 1991 by Kim Solez and Lorraine C. Racusen in Banff, Canada. The initiative was inspired by the then recent development of a consensus grading system for diagnosis of rejection in cardiac allografts led by Dr Margaret Billingham, a key participant at the first Banff meeting. Prior the Banff Classification there was no standardized, international classification for renal allograft biopsies, which resulted in considerable heterogeneity among pathologists in characterization of renal allograft biopsies. The first Banff schema was published in 1993, and has since undergone updates at regular intervals. The classification is expanded and updated every two years in meetings organized by the Banff Foundation for Allograft Pathology. An evaluation of the Banff Classification in March 2000 confirmed significant association between the revised Banff 97 classification and graft outcome. ...

Background: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. Methods: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction [Med Arch 2017; 71(6.000): 408-411]. Keywords: End-stage renal disease, Echocardiography, Kidney transplantation, Cardiovascular disease. >>Full text PDF >>Abstract >>(10.5455/medarh.2017.71.408-411). ...

Requiring a formal patient education class may help reduce disparities in kidney failure patients access to kidney transplantation.. Being educated about your health and your treatment options is a good thing. According to a new study, kidney failure patients who take part in an education program are more likely to get evaluated for a kidney transplant. The study appears in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that requiring a formal patient education class may help reduce inequities in kidney failure patients access to kidney transplantation.. Kidney transplantation is the preferred treatment for kidney failure. Among kidney failure patients, blacks are less likely to receive kidney transplants than whites for reasons that are unclear. Unfortunately, few published studies have looked at interventions that might reduce such racial disparities in access to kidney transplantation.. In an attempt to educate patients about the ...

OBJECTIVE Renal transplantation with a well-functioning graft leads to a rapid restoration of endocrine and sexual functions. The aim of this study was to examine our experience with pregnancies among renal transplant patients, particularly with regard to their impact on graft function. PATIENTS AND METHODS We analyzed 10 pregnancies in 7 renal transplant recipients for long-term graft outcomes in terms of clinical and biological data. RESULTS The mean patient age was 28.5 +/- 4 years. They all received a living donor kidney. The time between transplantation and the onset of pregnancy was 33.4 +/- 23.2 months. Regarding the immunosuppressive therapy, all patients received steroids and cyclosporine; 4 patients received in addition azathioprine and 2 received mycophenolate mofetil that was changed at 1 month before conception to azathioprine. There was no significant difference between the serum creatinine before and during pregnancy. We did not observe any acute rejection episode. Pregnancy

Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.. Although avoiding HLA [human leukocyte antigen; cell surface antigens that regulate host cell responses to transplanted cells] antigen mismatching has been shown to benefit long-term graft survival, it has raised concerns about disadvantaging minority groups, particularly black patients, and pediatric patients, who have severe growth retardation and other problems when dialysis is prolonged before transplantation, the authors write as background information in the article. Currently, only HLA-DR matching is considered in the United Network for Organ Sharing (UNOS) organ allocation system.. To examine the relationship between HLA-DR mismatching and rejection, graft survival and ...

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Purpose: We have previously shown that transplant of kidneys from donor mice latently infected with murine cytomegalovirus (CMV) into naïve recipients treated with clinically relevant immunosuppression results in CMV reactivation and systemic dissemination. Our study is to determine the cellular and molecular mechanisms underlying CMV dissemination following kidney transplantation in immunocompromised recipients by blocking inflammatory mediators associated with transplant injury.. *Methods: Kidneys from BALB/c mice latently infected with Smith murine CMV were transplanted to binephrectomized naïve immunodeficient NSG mice deficient of T cells, B cells and NK cell function. Recipients were treated with various extracellular mediator blockers, including anti-IL-1β, anti-IL-6 receptor, anti-IL-18 receptor, anti-CD40L, anti-TNFα, or a cocktail mixed with the above antibodies. At endpoints, kidney grafts, spleens, salivary glands and lungs were collected for CMV immediate early (IE) gene copy ...

A kidney transplant is a life-changing and life-saving procedure. Yet, a new study conducted by Mayo Clinic and the University of Michigan shows that only one-third of patients who ultimately receive a living donor kidney transplant receive it pre-emptively (i.e., before starting dialysis). Less than two-thirds receive a transplant either pre-emptively or within a year of starting dialysis.. Existing research suggests that less time spent on dialysis before transplant can improve patient outcomes and survival after transplant. However, this new research shows there has been no increase in the utilization of what is known as timely living donor kidney transplants, which includes pre-emptive and early transplants, since 2006. The study Under-utilization of timely kidney transplants in those with living donors, was published recently in the American Journal of Transplantation.. Read more. ...

TY - JOUR. T1 - Cancer and mTOR inhibitors in kidney transplantation recipients. AU - Kao, Chih Chin. AU - Liu, Jia Sin. AU - Chang, Yu Kang. AU - Lin, Ming Huang. AU - Lin, Yen Chung. AU - Chen, Hsi Hsien. AU - Chang, Wei Chiao. AU - Hsu, Chih Cheng. AU - Wu, Mai Szu. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Previous studies show that mTOR inhibitors decrease the risk of cancer development after kidney transplantation. However, the effect of cumulative doses of mTOR inhibitors on cancer after kidney transplantation is not well known. Methods: In the current study, patients were registered into a national database in Taiwan. Between year 2000 and 2013, 4,563 patients received kidney transplantation. They were divided into two groups, according to mTOR inhibitors usage. The cumulative dose of mTOR inhibitors was recorded. Patients were followed-up until de novo cancer development, death, or the end of 2014. Results: Patients were divided into two groups: mTOR inhibitors users (study group, ...

Purpose: To assess high hospital inpatient [IP] admissions and emergency department [ED] utilization within a 9-month period after kidney transplantation in order to identify potential mutable factors for reducing post-transplant health care utilization.. *Methods: This was a 9-year retrospective study in adult kidney transplant recipients from 01/2007-12/2015. Patients with previous transplant, or graft loss or death within 3 months post-transplantation, were excluded. Comprehensive resource utilization data were retrieved from state All-Payer Public Use data files. Patients with ≥2 IP admissions or standalone ED visits within 4-12 months post-transplantation were classified as high IP or ED utilizers. Multivariable logistic regression models were used for examining associations of predictors with high IP or ED utilization.. *Results: Of 1,280 kidney recipients, 209 (16.3%) and 183 (14.3%) were categorized as IP and ED high utilizers; respectively. Factors significantly associated (Figure 1) ...

TY - JOUR. T1 - Severe neurologic toxicity induced by cyclosporine A in three renal transplant patients. AU - Palmer, B. F.. AU - Toto, R. D.. PY - 1991. Y1 - 1991. N2 - Cyclosporine A (CyA) is a potent immunosuppressive agent that is used in organ transplantation and in a variety of immunological diseases. It has a variety of adverse side effects, some of which can be serious and even life-threatening. CyA-associated neurotoxicity is generally mild, consisting of fine tremor. However, more complex neurologic abnormalities, including motor spinal cord and cerebellar syndromes, have rarely been described in bone marrow and liver transplant patients. Renal transplant patients have been spared from such CyA-induced toxicity. In this report, three renal transplant patients are described who developed complex and severe neurologic toxicity in the setting of therapeutic blood levels of CyA, which was completely reversible on discontinuation of the drug. No patient had a prior history of neurological ...

TY - JOUR. T1 - Glomerular filtration rate in children following renal transplantation. AU - Seikaly, Mouin G.. AU - Browne, Richard. AU - Simonds, Nancy. AU - Atkins, Carolyn. AU - Alexander, Steven R.. PY - 1998/8/1. Y1 - 1998/8/1. N2 - Most studies evaluating renal function post-renal transplantation in children have used serum creatinine (SCr) or estimates of its clearance (CSCH). When renal function is impaired both SCr and the CSCH overestimate glomerular filtration rate (GFR), especially during cyclosporine therapy. This study measured GFR in 64 children (age range: 4-19 years) with stable renal function who received renal allografts at the Childrens Medical Center of Dallas, 31 from live related donors (LRD) and 33 from cadaveric donors (CAD). 125I- iothalamate clearance (CIO) was used as the reference standard for measuring GFR. Data from 100 CIO studies, were analyzed and results reported as mean ± S.E.M. CIO performed during the first year after renal transplantation in 23 children ...

View Poster. INTRODUCTION. Marginal kidneys have gained progressive acceptance with the use of extended criteria donor (ECD) kidneys, however there still remains high discard rates of these allografts. Increasing the donor pool can be accomplished through allocation for dual kidney transplantation (DKT) which has shown comparable outcomes to those from single kidney transplantation (SKT). This study analyzed the outcomes of DKT compared to SKT from marginal kidneys.. METHODS. Electronic databases including MEDLINE, EMBASE, PubMed and Cochrane library were searched using Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Each paper included was reviewed in duplicate. Patient factors including mean age of donors and recipients, gender and length of follow up was analyzed. The outcome measures analyzed included the cold ischemia time, graft survival, patient survival, serum creatinine in follow up and delayed graft function (DGF) in DKT compared to SKT. RESULTS. 17 publications ...

TY - JOUR. T1 - Kidney allograft survival outcomes in combined intestinal-kidney transplant. T2 - An analysis of the UNOS/OPTN database 2000-2014. AU - Moinuddin, Irfan. AU - Yaqub, Muhammad Sohail. AU - Taber, Tim. AU - Mujtaba, Muhammad. AU - Sharfuddin, Asif. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background and objectives: Intestinal transplants carry a high morbidity/mortality. Kidney allograft outcomes after combined intestinal (IT) with kidney transplant (CIKT) remain largely uninvestigated. Materials and methods: The UNOS STAR database was queried to identify all such combined organ transplants from 2000 to 2015. Results: Out of a total 2215 (51.4% peds vs 48.6% adults) intestinal transplants, 111 (5.0%) CIKT were identified (32.4% peds vs 67.6% adults). Over the study period of CIKT, a total of 45.9% of these cases died with a functioning kidney graft. DGF rate was 9.0%. The 1-year reported kidney acute rejection rate was 6.3%. For the entire CIKT population over the entire study era, the ...

EBV viremia occurs frequently after transplantation and can be related to post-transplant lymphoproliferative disorders (PTLD). However, the consequences of the majority of viremia are unclear. Barnoulid et al. followed EBV viral loads in 383 kidney transplant patients during the first year post-transplant. 40% of patients had at least one detected viremia; viremia was more common in EBV mismatched patients and those that received ATG. While these risk factors for EBV are well known, the authors also found that EBV infection was associated with opportunistic infection and graft loss. This study adds to our knowledge on EBV although further work is necessary to determine what to do with patients who had chronic low level viremia.. ...

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Definition of kidney transplantation in the Definitions.net dictionary. Meaning of kidney transplantation. What does kidney transplantation mean? Information and translations of kidney transplantation in the most comprehensive dictionary definitions resource on the web.

UAB has become a national leader in kidney transplantation since performing our programs first kidney transplant in 1968. Currently, the UAB Kidney Transplant Program is one of the largest kidney transplant centers in the nation, performing almost 300 transplants each year. Our reputation for excellence is based on our highly skilled transplant doctors, multidisciplinary team of specialists, dedication to patient care and education, and exceptionally high patient survival rates. Moreover, our patients benefit from our long history of experience and achievement in kidney transplantation. Since 1987, UAB has performed more living donor kidney transplants than any other kidney program in the United States, according to the United Network for Organ Sharing.. In 2006, UAB became the first transplant center in the Southeast to pursue paired-kidney exchange, a special type of living-donor arrangement. Blood-type and tissue incompatibility can be barriers to a successful donor-recipient match. However, ...

Ethical issues in kidney transplantation – reflections from Nigeria Joseph Olusesan Fadare1, Babatunde L Salako21Department of Medicine, Kogi State Specialist Hospital, Lokoja; 2Department of Medicine, University of Ibadan, Ibadan, NigeriaAbstract: Organ transplantation has become a life-saving procedure for many disease conditions hitherto considered incurable. Kidney transplantation, now the treatment of choice for end-stage renal disease, is the commonest solid organ transplantation carried out in the world at the moment and it is the only solid organ transplantation done in Nigeria. This procedure, in addition to prolonging lives, also provides better quality of life and is evaluated as cost-effective, because it makes more resources available to other sectors of the economy. Organ transplantation in general and kidney transplantation in particular are fraught with ethical issues and dilemmas worldwide. Some of the ethical issues arising in the setting of developing countries like Nigeria may

First of all, I apologize that the topic of the seminar has been announced to be the introduction of kidney transplantation at Rigshospitalet. During the past months, my focus has changed, and the material that I would like to discuss on Tuesday is the first and incomplete draft for an article on the history of organisation of kidney transplantation in Denmark from the mid-1960s onwards, thus a much wider topic. My purpose in the text is to examine different perspectives on how this organisation changed, primarily with a focus on the early period from ca. 1965 to 1980.. I plan to examine three such perspectives. The following text includes only the first one, and I have not yet written the remaining two, but I will present them all very briefly here. First, I look at how clinical changes in the transplantation of organs, mainly extended possibilities for the use of kidneys from dead donors, justified changes to the organisation of kidney transplantation in Denmark around 1970. The second ...

Background: Available data suggests that cyclosporin and tacrolimus differ in respect of nephrotoxicity and long term graft function in kidney transplantation. The aim of this study was to evaluate the impact of converting stable kidney allograft recipients from CyA-Me to TAC on renal function and cardiovascular risk profile. Material/Methods: 31 patients with stable renal function (Scr <3.0 mg/dl) were successfully switched from CyA-Me to TAC and followed up for 24 months. Majority (77.4%) had suspicion of CyA nephrotoxicity. Renal function was measured as serum creatinine (Scr) and calculated GFR. Office blood pressure and lipid profiles were evaluated. Results: 29 patients finished the 24 month observation period. 1 and 2 year patients survival was 100%; grafts survival was 93.5% and 91% respectively. No new cases of diabetes mellitus were identified. Mean SCr fell from 2.28±0.4 to 1.95±0.4 mg/dl (P<.02) and calculated GFR increased from 49.1±15 to 55.2±16 mL/min (P<.05). Total

Introduction: Direct-acting antivirals (DAAs) are widely used in the treatment of hepatitis C virus (HCV) infection in renal transplant recipients. Aim: The aim was to study the efficacy and safety of these drugs in our renal transplant recipients. Study Design, Subjects, and Methods: A retrospective observational study was performed among the renal transplant recipients , 18 years of age who were treated with DAA for HCV infection. The viral genotype, DAA regimen, the viral load at various time intervals, FibroScan score at the start and at the end of therapy, the changes in graft function (estimated glomerular filtration rate) and in the dosage of calcineurin inhibitors during therapy, and side effects if any during therapy were documented from history and transplant records. The viral remission rates and the safety of DAA were analyzed. Statistical analysis was done with Medcalc statistical software version 12.7.0.0. Results: Thirty-three recipients were included in the study. The DAA ...

The January 2018 issue of the Journal of the American Medical Association features the article Association of Race and Ethnicity with Live Donor Kidney Transplantation in the United States From 1995 to 2014 authored by Tanjala S. Purnell and colleagues including Lisa Cooper, Deidra Crews and Ebony Boulware from the DOM. The study aims to estimate changes over time in racial/ethnic disparities in live donor kidney transplantation (LDKT) in the U.S. utilizing data from the Scientific Registry of Transplant Recipients between January 1995 to December 2014, with follow-up thorough December 2016. The articles notes that their findings exist amidst numerous interventions to address racial/ethnic disparities in LDKT including addressing barriers to knowledge, cultural concerns, attitudes, beliefs, behavior and policies to address economic barriers.. Of the over 450,000 adult kidney transplant candidates whose data was analyzed between 1995 and 2014, 13.1 percent received LDKT. The major findings from ...

TY - JOUR. T1 - Posttransplant lymphoproliferative disorders in adult and pediatric renal transplant patients receiving tacrolimus-based immunosuppression. AU - Shapiro, Ron. AU - Nalesnik, Michael. AU - McCauley, Jerry. AU - Fedorek, Sheila. AU - Jordan, Mark L.. AU - Scantlebury, Velma P.. AU - Jain, Ashok. AU - Vivas, Carlos. AU - Ellis, Demetrius. AU - Lombardozzi-Lane, Susanne. AU - Randhawa, Parmjeet. AU - Johnston, James. AU - Hakala, Thomas R.. AU - Simmons, Richard L.. AU - Fung, John J.. AU - Starzl, Thomas E.. PY - 1999/12/27. Y1 - 1999/12/27. N2 - Between March 27, 1989 and December 31, 1997, 1316 kidney transplantations alone were performed under tacrolimus-based immunosuppression at our center. Posttransplant lymphoproliferative disorders (PTLD) developed in 25 (1.9%) cases; the incidence in adults was 1.2% (15/1217), whereas in pediatric patients it was 10.1% (10/99; P,.0001). PTLD was diagnosed 21.0±22.5 months after transplantation, 25.0±24.7 months in adults and 14.4±18.2 ...

Live Donor Kidney Transplantation: Updates in Paired Kidney Exchange Miguel Tan, MD, FRCSC Surgical Director, Kidney & Pancreas Transplantation Piedmont Transplant Institute Outline 1. 2. 3. Current statistics for kidney transplantation in the United States Living donor outcomes Paired exchange, impact, logistics and challenges Patients on the waiting list on December 31 of the year (active listings only) Organ supply continues to be a problem in kidney transplantation Almost 100 000 patients on waiting list Average waiting time to transplant 4- 5 years 4% of potential recipients die while waiting on list annually Transplants performed during the year (adult & pediatric combined) Deceased kidney donation rates Organ discard rate for organs recovered for transplantation Possible reasons for lack of growth of supply include -lack of education on donation options ie. living donation, paired exchange, desensitization -Increasing rate of morbid obesity and diabetes resulting poorer quality of organs ...

TY - JOUR. T1 - There are no differences in pretransplant characteristics of individuals receiving simultaneous pancreas-kidney transplant and individuals with type 1 diabetes mellitus receiving living-related kidney transplant. AU - Donigan, L.. AU - Stevens, R. B.. AU - Wrenshall, L.. AU - Larsen, J.. PY - 2004/5. Y1 - 2004/5. N2 - Abstract Simultaneous pancreas-kidney transplantation (SPK) recipients have longer survival compared to type 1 diabetes mellitus (DM1) cadaveric kidney recipients. However, DM1 living-related kidney transplant (KTX-LR) recipients have the same mortality as SPK recipients. It is unknown whether cardiovascular (CVD) risk factors pretransplant are similar between the two groups, SPK and DM1 KTX-LR. We analyzed pretransplant characteristics of SPK recipients (n = 39) and DM1 KTX-LR/living unrelated (LUR) recipients (KTX-LR/LUR, n = 20). In individuals who had multiple transplants, only pretransplant data from the first transplant was used. As all characteristics of ...

Living donor kidney transplantation , Living donor kidney transplantation , کتابخانه الکترونیک و دیجیتال - آذرسا

The purpose of this review was to investigate this in more detail-in particular the choice between a simultaneous pancreas-kidney transplantation and

Laparoscopic living donor kidney transplantation. Laparoscopic nephrectomy for kidney transplant has been established as a mainstream procedure both in Europe and the US because it allows donors to resume their daily activities very quickly.. In 2015 we performed the first laparoscopic living donor kidney transplant in a male patient following laparotomy. This 68-year-old patient had previously undergone surgery due to a car accident. Two 5mm trocars and one 10mm trocar were placed on the left midclavicular line, from the costal arch towards the anterior superior iliac spine and, a 10 mm trocar has been placed in the suprapubic area, which was replaced by a gelport for transplant removal.. Surgery lasted three hours. Warm ischemia time was three minutes.. The graft was immediately placed and the recipient had immediate diuresis with beginning of the renal function.. The postoperative course of the donor was unhindered and he was discharged from hospital on the fourth postoperative day.. The ...

TY - JOUR. T1 - A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation. AU - Bailey, Pippa. AU - Tomson, Charles. AU - MacNeill, Stephanie. AU - Marsden, Ann. AU - Cooke, Rhian. AU - Cook, Dominique. AU - Cooke, Rhian. AU - Biggins, Fiona. AU - OSullivan, Jim. AU - Ben-Shlomo, Yoav. PY - 2017/11. Y1 - 2017/11. N2 - This multicentre prospective potential living kidney donor cohort study investigated which sociodemographic and other factors predict progression to living kidney donation or donor withdrawal, as little is known on this topic. Data were collected on individuals undergoing living donor assessment at 7 UK hospitals from 01/08/14 to 31/1/16. Multivariable logistic regression was used to explore the relationships between donor and recipient characteristics and likelihood of kidney donation. 805 individuals presented for directed donation to 498 intended recipients. 112 intended recipients received a transplant from a ...

We are a leading center for living donor kidney transplant and incompatible blood type kidney transplant in adult and pediatric kidney transplant patients.

Live donor kidney transplantation has become a widely sought treatment by patients with end-stage renal failure. As the outcome for the genetically and emotionally related live donor transplants is the same, this review considers live kidney transplantation from the broad scope of current international practice. Unrelated live donor transplantation can now be performed for incompatible donor recipient pairs via a simultaneous paired kidney donation. However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. At a recent World Health Organization (WHO) conference of Middle East transplant professionals a statement of unequivocal opposition to commercialism was drafted. In the United States, the Institute of Medicine has recently published a significant report that affirms the legal prohibition of organ sales. These documents are in ...

TY - JOUR. T1 - Urine proteomic profiling for biomarkers of acute renal transplant rejection.. AU - Liang, Shu Ling. AU - Clarke, William. PY - 2010. Y1 - 2010. N2 - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection of rejection is crucial for treatment of rejection, and can help avoid long-term effects such as chronic rejection or loss of the transplanted organ. The current diagnostic paradigm is a combination of clinical presentation, biochemical measurements (serum creatinine), and needle biopsy. There are significant efforts underway to find alternate biomarkers for early detection of acute rejection, including protein profiling of urine by mass spectrometry. One approach for protein profiling is to use affinity mass spectrometry - we describe a method for this using ProteinChips and SELDI-TOF mass spectrometry.. AB - Acute allograft rejection is a serious impediment to long-term success in renal transplantation. Early detection ...

The development of the meeting and workgroups, rationale for the topics, process of creating consensus, and top recommendations are outlined in more detail in an overview meeting report (3). Recommendations included strategies to educate patients with CKD and ESRD, potential living donors, and the public; efficiencies in processes; policy initiatives; and a research agenda. An important and recurring theme was the importance of coordination and communication between providers throughout the continuum of disease to most effectively reach patients and their support systems. This moving points edition will address consensus conference recommendations for a collaborative approach to care, education, and access to improve overall practice in LDKT and LKD.. Five articles address how transplant centers and community nephrology care teams can partner for improved practices. In the first article, Living Donor Kidney Transplantation: Improving Education Outside of Transplant Centers about Live Donor ...

Slow graft function after pediatric renal transplantation from volunteer live donors , Slow graft function after pediatric renal transplantation from volunteer live donors , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی

TY - JOUR. T1 - Genomics of chronic allograft injury. AU - Akalin, Enver. AU - OConnell, Philip J.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010/12. Y1 - 2010/12. N2 - Chronic allograft injury (CAI) is common after kidney transplantation in which immunological (e.g., acute and chronic cellular and antibody-mediated rejection) and nonimmunological factors (e.g., donor-related factors, ischemia-reperfusion injury, polyoma virus, hypertension, and calcineurin inhibitor nephrotoxicity) have a role. Despite the new Banff pathological classification, histopathological diagnosis is still far from being the gold standard to understand the exact mechanisms in the development of CAI, which may lead to appropriate treatment. Microarray is a powerful technology that detects thousands of genes simultaneously and might be an important tool in elucidating patterns for mechanism, diagnosis, prognosis, and treatment of complex, multifactorial diseases, such as CAI. In this ...

Mesenchymal stem cells (MSCs) are multi-potent non-hematopoietic progenitor cells possessing an immune-regulatory function, with suppression of proliferation of activated lymphocytes. In this study, adult living donor kidney transplantation (LDKT) recipients were given MSCs derived from the donor bone marrow to evaluate the safety and the feasibility of immunological changes related to the intra-osseous injection of MSC into the bone marrow. MSCs were derived from negative HLA cross-match donors. Donor bone marrow was harvested 5 weeks prior to KT. At the time of transplantation, 1 x 106 cell/kg of donor MSC was directly injected into the bone marrow of the recipients right iliac bone. Patients clinical outcomes, presence of mixed chimerism by short tandem repeat polymerase chain reaction, analysis of plasma FoxP3 mRNA and cytokine level, and mixed lymphocyte reaction (MLR) were performed. Seven patients enrolled in this study and received donor MSC injections simultaneously with LDKT. The median age

Compared with kidney transplantation alone, simultaneous pancreas-kidney (SPK) transplantation was associated with an almost twofold lower 10-year mortality among type 1 diabetics, in a retrospective study.. The study included all 2,796 patients with type 1 diabetes in the Netherlands who started renal replacement therapy or received a first kidney transplant between 1986 and 2016. As reported in Diabetes Care, of the 996 who received new kidneys, 42% received a deceased-donor kidney; 16%, a living-donor kidney; and 42%, an SPK transplant. Crude survival was highest in SPK recipients and lowest in recipients of a deceased-donor kidney. Median survival time was 7.3 years for deceased-donor kidney recipients; 10.5 years for living-donor kidney recipients; and 16.5 years for SPK recipients.. @media (min-width:500px){#social{padding:0 0 15px 67px}#link{display:none!important}#facebook{padding:0 29px 0 24px}}@media screen and ...

A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.

A living donor kidney transplant takes an organ from a living donor and transplants it to the recipient. Learn more about living kidney donation here.

TY - JOUR. T1 - Psychiatric and psychological evaluation in living donor kidney transplantation: a single center experience. T2 - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. AU - Martinelli, V.. AU - Gregorini, M.. AU - Erasmi, F.. AU - Politi, P.. AU - De Pasquale, C.. AU - Pistorio, M.L.. AU - Abelli, M.. AU - Ticozzelli, E.. AU - Chiappedi, M.. AU - Pietrabissa, A.. AU - Rampino, T.. N1 - Export Date: 21 March 2021. PY - 2021. Y1 - 2021. M3 - Article. VL - 38. JO - G Ital Nefrol. JF - G Ital Nefrol. SN - 1724-5990. IS - 1. ER - ...

TY - JOUR. T1 - The Association of 25-Hydroxyvitamin D Levels with Late Cytomegalovirus Infection in Kidney Transplant Recipients. T2 - The Wisconsin Allograft Recipient Database. AU - Astor, Brad C.. AU - Djamali, Arjang. AU - Mandelbrot, Didier A.. AU - Parajuli, Sandesh. AU - Melamed, Michal L.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Background. Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in kidney transplant recipients. Vitamin D has an integral role in proper immune function, and deficiency is common among kidney transplant recipients. It remains unclear whether 25-hydroxyvitamin D [25(OH)D] level is associated with CMV infection in kidney transplant recipients. Methods. We examined the relationship between 25(OH)D levels, measured at least 6 months posttransplant, and subsequent CMV infection in 1976 recipients free of prior CMV infection. Results. Of 1976 recipients, 251 (12.7%) were vitamin D deficient [25(OH)D ,20 ng/mL] and 548 (27.7%) were insufficient ...

R SHINGDE1, V CALISA1, JC CRAIG2, JR CHAPMAN3, AC WEBSTER3, H. PLEASS3, P OCONNEL3L, R ALLEN3, P ROBERTSON3, L YUEN3, K KABLE3, B NANKIVELL3, N ROGERS3, G. WONG2,3. 1Centre for Kidney Research, The Childrens Hospital at Westmead, Westmead; 2Sydney School of Public Health, University of Sydney, Sydney; 3Centre for Transplant and Renal Research, Westmead Hospital, Westmead. Aim: To compare the absolute and relative health gains and costs of simultaneous pancreas kidney (SPK) with deceased donor kidney alone transplantation and dialysis in patients with type 1 diabetes mellitus (DM) and end-stage kidney disease (ESKD).. Background: The long-term costs and health benefits of SPK transplantation, compared to dialysis and deceased donor kidney alone transplant are unclear in this setting.. Methods: Two deterministic Markov models comparing patient survival in patients with Type I DM and ESKD who were either waitlisted on dialysis, received a SPK or deceased donor kidney alone transplantation were ...

Ethics of Living Donor Kidney Transplantation Interviewer: Quentin Cooper Interviewees: Mr Andrew Ready, Trustee and Lead Surgeon of TLC, Dr Shazia Shabir, Consultant Nephrologist at University Hospitals Birmingham and TLC volunteer, and Dr Dwomoa Adu, Consultant Nephrologist at Korle Bu Hospital, Accra, Ghana, and TLC Trustee Welcome to this TLC podcast in which science journalist,…

Understand more about why beliefs about organ donation within different communities may impact on decisions about living donor kidney transplantation amongst people from different ethnic backgrounds.. ...

TY - JOUR. T1 - Effects of dipeptidyl peptidase-4 inhibitors on hyperglycemia and blood cyclosporine levels in renal transplant patients with diabetes. T2 - A pilot study. AU - Bae, Jaehyun. AU - Lee, Min Jung. AU - Choe, Eun Yeong. AU - Jung, Chang Hee. AU - Wang, Hye Jin. AU - Kim, Myoung Soo. AU - Kim, Yu Seun. AU - Park, Joong Yeol. AU - Kang, Eun Seok. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Background: The use of dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing among renal transplant patients with diabetes. However, the glucose-lowering efficacies of various DPP-4 inhibitors and their effects on blood cyclosporine levels have not been fully investigated. We compared the glucose-lowering efficacies of DPP 4 inhibitors and evaluate their effects on the blood levels of cyclosporine in renal transplant recipients with diabetes. Methods: Sixty-five renal allograft recipients who received treatment with DPP-4 inhibitors (vildagliptin, sitagliptin, or linagliptin) following kidney transplant ...

TY - JOUR. T1 - Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study. AU - Citterio, Franco. AU - Hirsch, H. H.. AU - Vincenti, F.. AU - Friman, S.. AU - Tuncer, M.. AU - Wiecek, A.. AU - Scheuermann, E. H.. AU - Klinger, M.. AU - Russ, G.. AU - Pescovitz, M. D.. AU - Prestele, H.. PY - 2013. Y1 - 2013. N2 - Polyomavirus BK (BKV)-associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2%) patients having at least 2 BKV measurements until month 12 posttransplant. Univariate analysis associated CsA-MPA with lower rates of viremia than Tac-MPA at month 6 (10.6% vs. 16.3%, p = 0.048) and 12 ...

TY - JOUR. T1 - The power of renal function estimation equations for predicting long-term kidney graft survival a retrospective comparison of the chronic kidney disease epidemiology collaboration and the modification of diet in renal disease study equations. AU - Choi, Hoon Young. AU - Joo, Dong Jin. AU - Song, Mi Kyung. AU - Kim, Myoung Soo. AU - Park, Hyeong Cheon. AU - Kim, Yu Seun. AU - Kim, Beom Seok. N1 - Publisher Copyright: © 2016 Wolters Kluwer Health, Inc. All rights reserved.. PY - 2016. Y1 - 2016. N2 - Evaluation of renal function using an accurate estimation equation is important for predicting long-term graft survival. We designed this retrospective cohort study to evaluate the predictive power of renal function estimation by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) study equations for graft survival. We reviewed data of 3290 adult kidney transplant recipients who underwent transplantation at a single ...

Critical evaluation of radiolabeled lymphocytes to detect acute renal transplant rejection in a large animal model. - Get your full text copy in PDF #4818

Background: Kidney transplant (Tx) patients present a reduced cardiovascular (CV) mortality in comparison to the dialysis population, but in comparison to the general population, it is still several-fold higher. Methods: We studied risk factors for CV disease in a group of 38 patients (50% males, median age 36 years) who underwent a living donor Tx at the baseline and after 3 ± 1 and 9 ± 2 months. Results: The prevalence of overweight increased from 26 to 54% after Tx (p | 0.001). The mean systolic blood pressure decreased significantly after the Tx (148 ± 27.6 vs. 126 ± 12.7 mm Hg). There was a significant increase in LDL (97 ± 30 vs. 114 ± 35) and hematocrit (33.8 ± 4.4 to 42 ± 5.7%) levels and a significant reduction in fibrinogen levels (394 ± 91 vs. 366 ± 100 mg/dl) after 9 months as compared to the baseline. Obesity and dislipidemia were significantly correlated with inflammation. Significant changes in left ventricle mass index (293 ± 116 vs. 241 ± 96) were observed after the Tx.

TY - JOUR. T1 - Venous thromboembolic complications after kidney and kidney-pancreas transplantation. T2 - A multivariate analysis. AU - Humar, A.. AU - Johnson, E. M.. AU - Gillingham, K. J.. AU - Sutherland, D. E.. AU - Payne, W. D.. AU - Dunn, D. L.. AU - Wrenshall, L. E.. AU - Najarian, J. S.. AU - Gruessner, R. W.. AU - Matas, A. J.. PY - 1998/1/27. Y1 - 1998/1/27. N2 - Background: We reviewed the incidence of and risk factors for venous thromboembolic complications in our population of kidney (KTx) and simultaneous kidney-pancreas transplant (SPK) recipients. methods: Information was collected retrospectively from a database on 1833 KTx and 276 SPK recipients who underwent transplant surgery between January 1985 and August 1995. Results. The incidence of deep venous thrombosis (DVT) was 6.2%(n = 132), with significantly higher rates after SPK (18.1%) vs. KTx (4.5%) (P,0.001). The number of DVT episodes was highest in the first month; 17.5% occurred during this tine. For KTx recipients, ...

TY - JOUR. T1 - Association of prevalent vascular disease with allograft failure and mortality in live-donor kidney transplant recipients - a retrospective cohort study. AU - Mainra, Rahul. AU - Wong, Germaine. AU - Pilmore, Helen. AU - Lim, Wai H.. PY - 2019/6/26. Y1 - 2019/6/26. N2 - Limited data exist regarding the impact of prevalent vascular disease after live-donor kidney transplantation. We aimed to determine the associations between the number of prevalent vascular diseases, allograft, and patient outcomes following live-donor transplantation. This cohort study used data from the Australia and New Zealand Dialysis and Transplant Registry. Rates between recipients of live-donor kidney transplants ± prevalent vascular disease prior to transplantation were calculated. The associations between vascular disease, allograft failure, and all-cause mortality were assessed using Cox regression modeling. Kaplan-Meier proportions were used to calculate all-cause mortality and death with a function ...

TY - JOUR. T1 - Sero-molecular evaluation of human cytomegalovirus disease in renal transplant rejection.. AU - Kishore, Janak. AU - Mukhopadhyay, Chiranjoy. AU - Savitri, AU - Ayyagari, Archana. AU - Sharma, Rakesh Kumar. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Cytomegalovirus (CMV) is the most common viral pathogen in renal transplant recipients resulting in graft rejection. The prevalence of CMV disease and renal graft rejection is not well studied in India. Sequential specimens from 32 renal allograft recipients were examined by using CMV IgM specific mu capture ELISA and DNA by PCR. Twelve of the 32 patients were CMV IgM positive and out of 12 patients, 9 had rejection and 4 experienced CMV disease. CMV IgM specific mu capture ELISA helped in diagnosis of CMV disease, though it is less sensitive in detection of rejection. PCR itself was proved not sensitive enough in detecting either CMV disease or rejection. At present, optimal laboratory detection of CMV infection in these patients can be ...

TY - JOUR. T1 - Use of Ultrasound and Cystoscopically Guided Pancreatic Allograft Biopsies and Transabdominal Renal Allograft Biopsies. T2 - Safety and Efficacy in Kidney-Pancreas Transplant Recipients. AU - Kuhr, Christian S.. AU - Davis, Connie L.. AU - Barr, Darlene. AU - McVicar, John. AU - Perkins, James D.. AU - Bachi, Carlos E.. AU - Alpers, Charles E.. AU - Marsh, Christopher L.. PY - 1995. Y1 - 1995. N2 - The use of allograft biopsies to guide treatment after solid organ transplantation is a valuable tool in the detection and treatment of rejection. Prior development and use of the cystoscopically guided pancreatic allograft biopsy have allowed for more accurate and timely diagnosis of pancreatic allograft dysfunction, possibly contributing to our 1-year pancreas graft, renal allograft and patient survival rates of 87.1%, 88.5% and 96.8%, respectively. We reviewed our experience, examining efficacy and complication rates of pancreas and kidney biopsies in 31 cadaveric pancreas or ...

Pre-transplant nephrectomy is performed to reduce risks to graft and recipient. The aims of this study were to evaluate (1) indications, surgical approach, and morbidity of native nephrectomy and (2) the effects of kidney removal on clinical and biological parameters. This study was designed as a single-center retrospective cohort study in which 49 consecutive patients with uni- or bilateral native nephrectomies were identified from a total of 126 consecutive graft recipients in our pediatric kidney transplantation database between 1992 and 2011. Demographic, clinical, and laboratory details were extracted from charts and electronic records, including operation reports and pre- and post-operative clinic notes. Of the 49 nephrectomized patients, 47% had anomalies of the kidneys and urinary tract, 22% had cystinosis, 12% had focal segmental glomerulosclerosis, and 6% had congenital nephrotic syndrome. Nephrectomy decisions were based on clinical judgment, taking physiological and psychosocial aspects into

TY - JOUR. T1 - Isolated heart and liver transplant recipients are at low risk for polymavirus BKV nephropathy. AU - Puliyanda, Dechu P.. AU - Amet, Nurmamet. AU - Dhawan, Archana. AU - Hilo, Lara. AU - Radha, Raju K.. AU - Bunnapradist, Suphamai. AU - Czer, Lawrence. AU - Martin, Paul. AU - Jordan, Stanley. AU - Toyoda, Mieko. PY - 2006/5/1. Y1 - 2006/5/1. N2 - Background: BKV infection and nephropathy is a significant cause of allograft dysfunction in kidney transplantation. BKV viremia, rather than viruria, corresponds to BKV nephropathy. The prevalence of BKV viremia in non-renal solid organ transplants has not been systematically evaluated. Methods: We determined prevalence of BKV viremia in kidney, combined kidney-heart, kidney-liver, kidney-pancreas, kidney-heart-liver, and heart and liver transplant recipients using BKV-PCR. Results: Seven out of 173 (4%) kidney transplant recipients had BKV viremia, with BKV , 2 × 105 copies/mL in 6/7 and 1.9 × 103 in the remaining one patient. BKV ...

Chronic renal transplant rejection is a form of renal transplant rejection. It usually later following transplantation. Pathology Chronic rejection is defined as a gradual deterioration in graft function beginning at least 3 months after transp...

The Lorma Kidney Transplant Center provides personalized, holistic and best possible care to kidney transplant patients and their family. Our team is dedicated to make the entire kidney transplant process more convenient and less stressful for the patient. It has a multidisciplinary team composed of our best health care professionals who utilize evidence based practices and state-of-the-art diagnostic and surgical equipment.. Kidney Transplant: The best option for end-stage. Most often, kidney transplantation is the best treatment option for patients with chronic and end-stage renal disease. A kidney transplant is an operation that places a healthy kidney in the body. The transplanted kidney takes over the work of the two kidneys that failed and dialysis is no longer needed. Often,the new kidney will start making urine as soon as blood starts flowing through it. A successful kidney transplant affords a new beginning for ESRD patients because it offers enhanced quality and duration of ...

The ICAVL guidelines for transplant renal artery duplex ultrasound are similar to those for native arteries, with variations that include the need to examine the peri-transplant region with gray scale images, the arterial anastomosis with spectral Doppler waveforms and velocity measurements and the venous anastomosis with spectral Doppler waveforms. It should be noted that as external iliac artery stenosis can result in impaired blood flow to the transplanted kidney, this artery should also be interrogated as part of a complete examination.. Furthermore, it should be noted that transplant renal arteries have two characteristics that may cause elevated peak systolic velocity without stenosis. First, an end to side anastomosis may cause a local tortuosity and second, a transplant kidney tends to undergo hypertrophy and may be supplied by a higher than normal blood volume. Also, there is large normal variability of peak systolic velocity in transplant renal arteries.. Published peak systolic ...

BACKGROUND: Campath 1H is a depleting, humanized anti-CD52 monoclonal antibody that has now been used in 31 renal allograft recipients. The results have been very encouraging and are presented herein. METHODS: Campath 1H was administered, intravenously, in a dose of 20 mg, on day 0 and day 1 after renal transplant. Low-dose cyclosporine (Neoral) was then initiated at 72 hr after transplant. These patients were maintained on low-dose monotherapy with cyclosporine. RESULTS: At present, the mean follow-up is 21 months (range: 15-28 months). All but one patient are alive and 29 have intact functioning grafts. There have been six separate episodes of steroid-responsive rejection. One patient has had a recurrence of her original disease. Two patients have suffered from opportunistic infections, which responded to therapy. One patient has died secondary to ischemic cardiac failure. CONCLUSIONS: Campath 1H has resulted in acceptable outcomes in this group of renal allograft recipients. This novel therapy is of

Background: The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients.. Methods: A cross-sectional study was conducted to determine the prevalence of MS in 101 renal transplant recipients at Osaka City University Hospital. The prevalence of MS was determined using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria (modified and original) and the International Diabetes Federation (IDF) criteria.. Results: Using the modified (Japanese) NCEP criteria, a total of 24 out of 101 patients (23.8%) had MS including 21 out of 64 male patients (32.8%) and three out of 37 female patients (8.1%). Using the modified (Asian) NCEP criteria, MS was diagnosed in 23 patients (22.8%); 19 male (29.7%) and four female (10.8%). Using the original NCEP criteria, MS was diagnosed in 15 patients (14.9%); 12 male (18.8%) and three female (8.1%). ...

PURPOSE: The development of a symptomatic lymphocele (SL) is a frequent postoperative surgical complication after kidney transplantation. It may lead to pain and discomfort and cause transplant malfunction or even secondary graft loss. A large cohort of renal recipients was investigated to identify the possible risk factors for SL. METHODS: All renal transplant patients of a single centre were retrospectively analysed for SL between January 2010 and December 2017. The SL group was compared to a control group from the same cohort. RESULTS: 45 out of 1003 transplanted patients developed an SL (incidence 4.5%), on average 50 days after kidney transplantation. SLs developed more in older patients, in those with a PD catheter and in ADKDP as primary diagnosis. Surgical predictors for SLs were venous anastomosis on the external iliac vein, concomitant PD catheter removal, perfusion defects, shorter operating time, splint , 7 days, double J stenting, discharge with drain, low initial drain production ...

Heres my already-submitted public comment to OPTN on their proposed policy for living kidney donor follow-up. The deadline for comment is December 23rd, so theres still time to compose and submit your own. The purpose of this missive is to respond to the proposed policy to establish minimum requirements for living kidney donor follow-up. Nearly 60 years after the first LKD transplant, there have been no randomized controlled trials to determine the testing required for the evaluation of living kidney donors(1). Transplant programs have little data to guide them in deciding which donors are unacceptable, or which characteristics are associated with kidney disease or poor psychosocial outcomes after donation(2) . Published studies are either single center, susceptible to selection bias and small sample sizes, or compare living donors the general public, an incorrect cohort(3) . Meanwhile, over the past 30 years, living kidney donors have gotten older, increased in pre-donation BMI, and decreased ...