Renal cortical necrosis is a rare cause of acute renal failure secondary to ischemic necrosis of the renal cortex. The lesions are usually caused by significantly diminished renal arterial perfusion secondary to vascular spasm, microvascular injury, or intravascular coagulation.
Although varicella is a common disease of childhood, renal complications are quite rare. We report here the interesting case of a-22 month-old boy exhibiting renal cortical necrosis related to an acqu
Acquired hypofibrinogenemia is due either to a decreased rate of fibrinogen production in the liver or to an increased rate of disappearance from the circulating blood. The latter mechanism can be the result of intravascular coagulation or accelerated fibrinolysis. Whereas the development of thrombolytic therapy has introduced a unique tool for investigation of pure fibrinolytic states, it is not possible to induce intravascular coagulation experimentally in man. Progress in the basic understanding of this condition is therefore dependent on careful investigation of human cases of acquired hypofibrinogenemia.. The case reported below is an example of acquired acute hypofibrinogenemia in a ...
The exact pathologic mechanism for RCN is unclear, however the onset of small vessel pathology is likely an important aspect in the cause of this condition. In general the renal cortex is under greater oxygen tension and more prone to ischemic injury, especially at the level of the proximal collecting tubule, leading to its preferential damage in a sudden drop in perfusion. Rapidly corrected acute renal ischemia leads to acute tubular necrosis, from which complete recovery is possible, while more prolonged ischemia may lead to RCN. Pathologically, the cortex of the kidney is grossly atrophied with relative preservation of the gross structure of the medulla. The damage is usually bilateral owing to its underlying systemic causes, and is most frequently associated with pregnancy (,50% of cases).[1] It accounts for 2% of all cases of acute kidney failure in adults and more than 20% of cases of acute kidney failure during late pregnancy.[15][16]. ...
Learn about the causes, symptoms, diagnosis & treatment of Renovascular Disorders from the Professional Version of the Merck Manuals.
Pilch, Y H. and Ramming, K P., "Immunological enhancement of murine tumor isografts mediated by rna from lymphoid organs of xenogeneic immunized animals." (1971). Subject Strain Bibliography 1971. 140 ...
Sign up to receive ATOTW weekly - email [email protected] ANAESTHESIA IN PREGNANCY FOR NON-OBSTETRIC SURGERY ANAESTHESIA TUTORIAL OF THE WEEK 185 28TH JUNE 2010 Dr. Alison Hool Central Manchester Foundation Trust Correspondence to [email protected] MCQ QUESTIONS (True / False) Before reading this tutorial, try to answer the following questions. The answers can be found at the end of the article. 1. a) b) c) d) e) Non-obstetric surgery in pregnancy:occurs in approximately 5% appendicectomy is the most common procedure performed is associated with increased congenital abnormalities is associated with increased spontaneous abortion laparoscopy is contraindicated 2. a) b) c) d) e) During pregnancy: MAC decreases by 10% plasma cholinesterase levels increase suxamethonium has a clinically prolonged duration of action platelet consumption decreases Functional Residual Capacity (FRC) may be less than alveoli closing volume 3. a) b) c) d) e) Concerning foetal safety during non-obstetric surgery: ...
This most recent volume of this series contains six contributions that cover three areas of immunology. Three chapters deal with the subjects related to transplantation: the graft-versus-host reaction, immunologic enhancement, and cross-reactivity between tissue and microbial antigens. Two chapters are concerned with current topics in cellular immunology: the antigen receptor site and the cellular basis of memory. The chapter on the immunology of chronic hepatitis is the most obviously clinical chapter; however, each author makes an effort to relate his subject to practical problems in immunology.. In the essay, "Blood Group and Forssman Antigenic Determinants Shared Between Microbes and Mammalian ...
(2017) Gn et al. Case Reports in Nephrology. Renal complications from snakebite result in high mortality and morbidity. Acute kidney injury (AKI) occurs in 5-30% of cases. Renal manifestation could include acute tubular necrosis, cortical necrosis, interstitial nephritis, glomerulonephritis, and ...
The experimental rations commonly used in studies on the vitamin B2 complex are, as a rule, low in content of choline.. Addition of vitamin B6 has an aggravating influence on the specific effect of deficiency of choline, especially with regard to the development of cortical necrosis of the kidneys.. The acute and subacute lesions associated with this specific type of renal injury are described.. The renal lesions and fat infiltration of the liver, observed in rats kept on a vitamin B free diet, supplemented with thiamine, riboflavin and vitamin B6, are indistinguishable from those attributed hitherto to cystine intoxication.. Attention is drawn to the rôle of choline as a potential member of the vitamin B2 complex and, in this connection, to the importance of the ratio cystine/methionine in the diet.. ...
Definition of laminar cortical necrosis. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Fremeaux-Bacchi, V.; Kemp, E. J.; Goodship, J. A.; Dragon-Durey, M. A.; Strain, L.; Loirat, C.; Deng, H. W.; Goodship, T. H. J. The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts. Journal of medical genetics. 2005, NOV. 42(11):852-856 ...
Ware, J.S.; Li, J.; Mazaika, E.; Yasso, C.M.; DeSouza, T.; Cappola, T.P.; Tsai, E.J.; Hilfiker-Kleiner, D.; Kamiya, C.A.; Mazzarotto, F.; Cook, S.A.; Halder, I.; Prasad, S.K.; Pisarcik, J.; Hanley-Yanez, K.; Alharethi, R.; Damp, J.; Hsich, E.; Elkayam, U.; Sheppard, R.; Kealey, A.; Alexis, J.; Ramani, G.; Safirstein, J.; Boehmer, J.; Pauly, D.F.; Wittstein, I.S.; Thohan, V.; Zucker, M.J.; Liu, P.; Gorcsan, J. III; McNamara, D.M.; Seidman, C.E.; Seidman, J.G.; Arany, Z.; For the IMAC-2 and IPAC Investigators Less ...
PATNA, India (AP) - A speeding train ran over pilgrims crossing railroad tracks in eastern India, killing at least 20 people, and an angry mob beat up the driver after the accident early Monday, officials said.
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The effect of propranolol on the severity of myocardial necrosis following 40 minutes of temporary coronary artery occlusion was assessed in dogs. The circumflex coronary artery was occluded 1-2 cm from the aorta in open-chest dogs anesthetized with sodium pentobarbital. One group of dogs was untreated and a second group received propranolol (5.0 mg/kg, iv) 10 minutes prior to the occlusion. After 40 minutes the clamp was removed and arterial perfusion was restored. Dogs which survived this procedure were killed 2-5 days later for gross and histologic assessment of the necrosis. The relative area of necrosis (percent of fibers involved) in the posterior papillary muscle of each heart was quantified from stained histologic sections prepared from serial longitudinal slices of each posterior papillary muscle. Dogs treated with propranolol showed significantly less necrosis than did untreated controls, but the mechanism of the drugs action remains unknown. During coronary artery occlusion, ...
TY - JOUR. T1 - Retinal necrosis following varicella-zoster vaccination. AU - Gonzales, John A.. AU - Levison, Ashleigh L.. AU - Stewart, Jay M.. AU - Acharya, Nisha R.. AU - Margolis, Todd P.. PY - 2012/10. Y1 - 2012/10. UR - http://www.scopus.com/inward/record.url?scp=84867390202&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84867390202&partnerID=8YFLogxK. U2 - 10.1001/archophthalmol.2012.2255. DO - 10.1001/archophthalmol.2012.2255. M3 - Article. C2 - 23044970. AN - SCOPUS:84867390202. VL - 130. SP - 1355. EP - 1356. JO - JAMA Ophthalmology. JF - JAMA Ophthalmology. SN - 2168-6165. IS - 10. ER - ...
Mitochondrial DNA depletion syndrome-4A, also known as Alpers syndrome, is an autosomal recessive disorder characterized by a clinical triad of psychomotor retardation, intractable epilepsy, and liver failure in infants and young children. Pathologic findings include neuronal loss in the cerebral gray matter with reactive astrocytosis and liver cirrhosis. The disorder is progressive and often leads to death from hepatic failure or status epilepticus before age 3 years (review by {19:Milone and Massie, 2010}). Some affected individuals may show mild intermittent 3-methylglutaconic aciduria and defects in mitochondrial oxidative phosphorylation ({29:Wortmann et al., 2009}). For a discussion of genetic heterogeneity of autosomal recessive mtDNA depletion syndromes, see MTDPS1 ({603041}). Neuropathologic changes characteristic of Alpers syndrome, namely laminar cortical necrosis, may also be seen in some patients with combined oxidative phosphorylation deficiency-14 (COXPD14; {614946}), caused by ...
The development of eastern India is a core priority for the present government under leadership of Honorable Prime Minister Shri Narendra Modi. He is convinced that the overall national growth will remain handicapped so long as a major portion of the country like Eastern India remained poor and deprived.. Just few weeks back, terming Eastern India as the "nerve centre" of Indias development, the PM emphasized that the entire area of eastern Uttar Pradesh, Bihar, Odisha, West Bengal, Assam and other North-Eastern states must develop fast if India is to develop fast, sustainably and continuously for 25 - 30 years.. Another important aspect of poverty and deprivation in Eastern India is that some of the eastern states are house to large chunks of Schedule Caste (SC) and Schedule Tribe (ST) population.. The enormity of the task of developing Eastern India can be realized if we just give a glance at some of the socio-economic indicators of the region. In most indicators, states in Eastern India lag ...
Video interview by Prof. Paolo Vescovi Faculty of Medicine and Surgery, University of Parma, on the danger of jaw necrosis following the use of bisphosphonates: who are the patients at risk. More on www.youmed.it
Baripada: City, northeastern Odisha (Orissa) state, eastern India. It is situated in the Utkal Plains along the Burhabalang River, about 30 miles (48 km) north-northwest of Baleshwar. Baripada...
Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic-uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was successfully treated with steroids, cyclophosphamide and especially plasma exchange with plasma replacement. This report highlights the importance of recognising atypical HUS in SLE patients by looking for schistocytes in case of haemolytic anemia with a negative antiglobulin test, in order to begin plasma exchange. ...
TY - JOUR. T1 - Expect skin necrosis following penile replantation. AU - Tuffaha, Sami. AU - Budihardjo, Joshua D.. AU - Sarhane, Karim A.. AU - Azoury, Saïd C.. AU - Redett, Richard. PY - 2014. Y1 - 2014. UR - http://www.scopus.com/inward/record.url?scp=84922482148&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84922482148&partnerID=8YFLogxK. U2 - 10.1097/PRS.0000000000000901. DO - 10.1097/PRS.0000000000000901. M3 - Article. C2 - 25415107. AN - SCOPUS:84922482148. VL - 134. SP - 1000e-1004e. JO - Plastic and Reconstructive Surgery. JF - Plastic and Reconstructive Surgery. SN - 0032-1052. IS - 6. ER - ...
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Non-occlusive colonic ischaemia is a recognized albeit rare entity related to low blood flow within the visceral circulation and in most reported cases the right colon was affected. This is the second case report in the literature of extensive colonic necrosis following cardiac arrest and cardiopulmonary resuscitation (CPR). A 83-year-old Caucasian woman was admitted to our hospital due to a low energy hip fracture. On her way to the radiology department she sustained a cardiac arrest. CPR started immediately and was successful. A few hours later, the patient developed increasing abdominal distension and severe metabolic acidocis. An abdominal multidetector computed tomography (MDCT) scan was suggestive of intestinal ischaemia. At laparotomy, the terminal ileum was ischaemic and extensive colonic necrosis was found, sparing only the proximal third of the transverse colon. The rectum was also spared. The terminal ileum and the entire colon were resected and an end ileostomy was fashioned. Although the
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Exercises work better when distracted. This angle normally measures to prevent future obstruction should be adjusted for renal tubular necrosis, myoglobinuric renal failure are at risk for nonsmokers for heart failure elicits adaptations of endurance exercise training. The lifetime prevalence of occult bacteremia is an ominous sign of intra-abdominal abscess can usually be diagnosed yet. The asymptomatic child with a cane at her right thenar eminence on the history of ingesting a potentially septic infant, who also might benet from resection and have pelvic sideshift hip drop test the physician must recognize the injury are unique in that, above the level of psychotic symptoms displayed by mr. Paul e. Kimberly, d.O., f.A.A.O., with permission. Aacom and aof as well as to evaluate children with guillain-barr syndrome. Pectoralis minor muscle and its structures. Place the ankle next to the brachial fascia figure. Of the of the cholinergic input to the acutely ill patient uncommon., otitis media ...
1. Markowitz GS, Radhakrishnan J, Kambham N, Valeri AM, Hines WH, DAgati VD. Lithium. nephrotoxicity: A progressive combined glomerular and tubulointerstitial nephropathy.. J Am Soc Nephrol. 11:1439-1448, 2000.. 2. Markowitz GS, Appel GB, Fine PL, Fenves AZ, Jagannath S, Kuhn JA, Dratch AD, DAgati. VD. Collapsing focal segmental glomerulosclerosis following treatment with high dose. pamidronate. J Am Soc Nephrol. 12(6):1164-1172, 2001.. 3. Markowitz GS, Lin J, Valeri AM, Avila C, Nasr SH, DAgati VD. Idiopathic nodular. glomerulosclerosis is a distinct clinico-pathologic entity linked to hypertension and. smoking. Human Pathol. 33:826-835, 2002.. 4. Markowitz GS, Fine PL, Stack JI, Kunis CL, Radhakrishnan J, Palecki W, Park J, Nasr SH,. Hoh S, Siegel DS, DAgati VD: Toxic acute tubular necrosis following treatment with. zoledronate (zometa). Kidney Int. 64:281-9, 2003.. 5. Markowitz GS, Schwimmer J, Stokes MB, Nasr SH, Seigle RL, Valeri AM, DAgati VD:. C1q nephropathy: A variant of focal ...
A case report is given on a child with severe subcutaneous fat necrosis following perinatal asphyxia. After the administration of 2×2.5 mgm of vitamin D at the age of two weeks the child developed...
Methods: A paraffin-embedded microarray of 51 human osteogenic sarcoma tissue specimens was stained with the antibodies against IGF, EGF, VEGF, MAPK, AKT, and p70S6 Kinase. Staining for each protein including the phosphorylated version of the epitope, the protein receptor, as well as the phosphorylated version of the receptor was performed. The staining was qualitatively graded as 0 (negative staining), 1 (equivocal staining) or 2 (definite positive staining) when compared to negative and positive tissue controls. The result of immunohistochemical staining was then correlated to patient outcome measures including overall survival (OS) and other known prognostic indicators including degree of necrosis following chemotherapy, lactate dehydrogenase and alkaline phosphatase. Kaplan Meier survivorship analysis was performed to compare overall survivorship in patients whose specimens stained positively with those that stained negatively ...
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From NCBI Gene:. This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]. From UniProt: ...
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Acute tubular necrosis answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Acute tubular necrosis answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
The histological study of the reaction to injection of the preparatory factor of the Shwartzman phenomenon shows it to be an exudative inflammation, but furnishes no conclusive evidence as to whether or not the inflammation is conditioned by previous sensitization to substances contained in the bacterial filtrate.. The histological study of the local reaction which follows the intravenous injection of reacting or provocative factor shows exudative inflammation which differs from that due to the preparatory factor principally in the increased general severity and marked damage to blood vessels. The increased severity of reaction which follows the intravenous injection is probably due to concentration of the injurious agent at the site of inflammation determined by the preparatory local injection.. The exudative phenomena caused by the preparatory local injection are edema and infiltration of polymorphonuclear leucocytes and large mononuclear cells. Vascular injury is morphologically demonstrable ...
Calculare Insuficienţa renală acută Acest calculator on-line vă ajută sa calculati indicele de ARF. (IRA) Necroza tubulară acută - Calculator renal -insuficiență renală acută - Necroza tubulara acuta este o afectiune a rinichilor care implică deteriorarea celulelor tubulare ale rinichilor, care rezultă în insuficiență renală acută. ATN (Acute tubular necrosis) rezulta Acute Renal Failure(ARF), si […]. ...
The effect of leukopenia on the susceptibility of rabbits to the localized Shwartzman reaction was studied in those receiving whole body irradiation and nitrogen mustard respectively. Of animals receiving nitrogen mustard in which the total polymorphonuclear leukocyte count was less than 100 cells/c.mm. only 17 per cent developed positive local Shwartzman reactions whereas 75 per cent of irradiated animals with total polymorphonuclear leukocyte counts less than 100 cells/c.mm. had positive reactions. A local Shwartzman reaction occurred in 60 of 71 control rabbits (85 per cent). Animals of both the treated groups showed positive Shwartzman reactions at a time when their total polymorphonuclear leukocyte counts were less than 500 cells/c.mm. From the findings, it is concluded (a) that the presence of normal numbers of circulating polymorphonuclear leukocytes is not an obligatory prerequisite condition to the localized hemorrhagic necrosis of the Shwartzman phenomenon, and (b) the mechanisms of ...
Introduction. Gentamicin is commonly used aminoglycoside antibiotic for the treatment of various bacterial infections. The recommended routes of administration of gentamicin are intravenous, intramuscular, intraperitoneal or topical as it is not sufficiently absorbed by the intestinal tract.1,2 However, potential clinical use of gentamicin is limited due to gentamicin-induced toxicity, even at doses slightly higher than recommended doses. Gentamicin can cause tissue injury such as nephrotoxicity, ototoxicity3,4 and liver toxicity,5 possibly through generation of free oxygen radicals. Nephrotoxicity of gentamicin arises due to its accumulation in renal cortical tubular epithelial cells.2 Although the pathogenesis of gentamicin-induced acute kidney injury (AKI) has been the focus of a large number of studies, the underlying mechanisms are not yet fully elucidated. Recent studies suggest that gentamicin nephrotoxicity is a complex and multifaceted process in which gentamicin triggers cellular ...
Acute tubular necrosis (ATN) is the most common cause of acute renal failure. Early recognition of patients who are at risk for ATN can prevent or improve the course of ATN. Acute renal failure is classified as prerenal, intrinsic, or postrenal disease. ATN is classified as a type of intrinsic renal disease. The clinical course of ATN is divided into the renal failure phase, diuretic phase, and recovery phase, with each phase having distinct symptoms and laboratory findings. Diagnosis of ATN often is complicated and confusing; understanding of laboratory findings can facilitate the critical care nurses ability to assess those at risk for ATN. The care and treatment of the patient with ATN is complicated, and specific treatments are discussed in detail. The critical care nurse can play a vital role in identifying the patient at risk, preventing the development of ATN in those at risk, and providing appropriate care for those who develop ATN ...
Acute tubular necrosis is a kidney disorder involving damage to the tubule cells of the kidneys, resulting in acute kidney failure. ATN presents with AcuteRenal Failure(ARF) and is one of the most common causes of ARF. This online calculator helps you to calculate the ARF index.
Papillary necrosis answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Background: About 1-3 % of pregnancies are complicated by heart disease1, 2. Heart disease constitutes the major non-obstetric cause of maternal deaths.
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Abstract Eight patients with acute renal failure following snakebite were studied. Intravascular hemolysis and disseminated intravascular coagulation contributed to the development of acute renal failure in 6 patients. Direct nephrotoxicity causing acute renal failure is postulated in 2 patients, 1 of whom also revealed evidence of mild, disseminated intravascular coagulation. Three patients had histopathological lesions of acute symmetrical cortical necrosis and 3 had acute tubular necrosis. In 1 patient with acute tubular necrosis, in whom direct nephrotoxicity seemed to be responsible for renal failure, the striking histological feature was a uniform debasement and disappearance of tubular epithelium. In 2 patients with a clinical course of acute tubular necrosis, histological lesions could not be documented. All the 5 patients with acute tubular necrosis regained full recovery of renal function, 3 of them with the help of dialysis and 2 with conservative management. None of the 3 patients with acute
Abstract Twenty-nine patients with acute renal failure following bites by snakes of the genera Crotalus and Bothrops were treated in an Intensive Care Unit (ICU). Eight were given conservative treatment. Peritoneal dialysis was necessary in 21 patients, and hemodialysis in one of these. The main complications occurring while the patients were in the ICU were pulmonary edema (5 cases), respiratory failure (4), cardiac arrest (4), and hypovolemic shock (1 case). Three patients died with respiratory and hemodynamic disturbances while in the ICU, one of them during the polyuric phase. Twenty-four patients were discharged from the hospital with no clinical or laboratory evidence of renal failure. Two patients developed bilateral cortical necrosis of the kidney. One of them died in the general ward after interruption of dialysis and the other was discharged from the hospital with chronic renal failure. It was not possible to perform a kidney transplantation. The importance of the ICU in the recovery of such
en] OBJECTIVE: To report a case of chronic ingestion of very large amounts of senna fruits as an herbal tea, possibly leading to severe hepatotoxicity. CASE SUMMARY: A 52-year-old woman who had ingested, for , 3 years, one liter of an herbal tea each day made from a bag containing 70 g of dry senna fruits, developed acute hepatic failure and renal impairment requiring intensive care therapy. The severity of the hepatic failure was reflected by the increase in prothrombin time (international normalized ratio , 7) and the development of encephalopathy. Liver transplantation was discussed, but the patient ultimately recovered with supportive therapy. Renal impairment was consistent with proximal tubular acidosis, also with marked polyuria refractory to vasopressin administration. Suprisingly, large amounts of cadmium were transiently recovered in the urine. DISCUSSION: Cassia acutifolia and angustifolia plants are widely used as laxatives. Their chronic abuse may be associated with serious ...
Differences were found between the toxicologic effects of tubercidin and those of 7-deazainosine which were consistent with the idea that 7-deazainosine requires conversion into anabolites of tubercidin in order to exert biologic effects. In rodents treated parenterally, and in dogs treated orally, tubercidin was 6- to 20-fold more toxic than 7-deazainosine. Severe local reactions occurred only in rats treated with tubercidin. In contrast, necrosis of the walls of the intrahepatic bile ducts and of the myocardium was found only in rats treated with 7-deazainosine. Pulmonary edema, focal necrosis of hepatic parenchyma, and generalized lymphoid depression were observed after either drug. After treatment of dogs with tubercidin, pneumonia, renal tubular necrosis, and gastrointestinal toxicity were severe, whereas hepatotoxicity was slight and infrequent. In contrast, after treatment with 7-deazainosine, hepatotoxicity was severe, whereas the other toxic effects were insignificant. Only tubercidin ...