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This is an open-label, 2-period crossover study in young healthy male subjects to evaluate the effect of multiple once daily doses of ketoconazole on the pharmacokinetics (PK) of darexaban and metabolites after a single dose of darexaban. In addition, safety and tolerability of darexaban administered alone and in combination with ketoconazole, is evaluated. Eligible subjects are admitted to the clinical unit in the morning of Day -1. The subjects are randomized to receive either first darexaban plus ketaconazole and then darexaban alone, or first darexaban alone followed by darexaban plus ketoconazole ...
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The purpose of this study is to determine the effectiveness of fenretinide (4-HPR/LXS) plus ketoconazole in the treatment of recurrent ovarian cancer or primary peritoneal carcinoma. In addition, researchers would like to determine if the drugs are most effective together or if fenretinide (4-HPR/LXS) is most effective alone ...
Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients Prostate Cancer and Prostatic Diseases advance online publication, February 10 2015. doi:10.1038/pcan.2015.2 Authors: E N Lo, L A Beckett, C-X Pan, D Robles, J M Suga, J M Sands &P N Lara...
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TY - JOUR. T1 - Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. AU - Taplin, Mary Ellen. AU - Regan, Meredith M.. AU - Ko, Yoo Joung. AU - Bubley, Glenn J.. AU - Duggan, Stephen E.. AU - Werner, Lillian. AU - Beer, Tomasz M.. AU - Ryan, Christopher W.. AU - Mathew, Paul. AU - Tu, Shi Ming. AU - Denmeade, Samuel R. AU - Oh, William K.. AU - Sartor, Oliver. AU - Mantzoros, Christos S.. AU - Rittmaster, Roger. AU - Kantoff, Philip W.. AU - Balk, Steven P.. PY - 2009/11/15. Y1 - 2009/11/15. N2 - Purpose: Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoconazole) and type I and II 5α-reductases (dutasteride) in patients with castration-resistant prostate cancer ...
This study investigated the effects of ketoconazole on the pharmacokinetics of refametinib [BAY86-9766; Bayer] in healthy male volunteers. The primary endpoints
Ketoconazole is an antifungal medication used for the treatment of serious, deep fungal infections, such as blastomycosis, histoplasmosis, aspergillosis, and cryptococcosis in dogs, cats, and other pets. It may also be used against some yeast and dermatophyte (ringworm) infections. It has also been used to treat Cushings disease (hyperadrenocorticism) in dogs. Contact your veterinarian if your pet experiences lack of appetite, vomiting, diarrhea, liver toxicity (jaundice - yellowing of gums, skin, or eyes) or bleeding problems while being treated with ketoconazole. Itraconazole, a similar medication, generally produces fewer side effects although it is more expensive.. ...
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Ketoconazole and selenium sulfide are antifungal agents used to treat itching, flaking, scaling, and dry skin on the scalp due to dandruff. Ketoconazole and selenium sulfide are also used for treating seborrhea (a red, itchy rash) and tinea versicolor, a fungal infection of the skin. Rash and itching are side effects of these two topical agents.
Medical specialists advise HDK to be taken three times a day in the first week. The recommended strength is 200 mg. The dosage of HDK is then raised to double the strength. However, the timings dont alter. To be efficacious, Ketoconazole is best taken on an empty stomach. The ideal time is midway between meals. That would be approximately two hours after one meal and two hours before the next. The reason is that absorption of Ketoconazole is much faster on an empty stomach, without the interference from other substances in medications such as histamines ...
This is an open label, phase II, single center trial of ketoconazole/dexamethasone to determine if the administration of ketoconazole/dexamethasone, aft
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We conducted an exploratory phase II study to assess the efficacy of treatment with ketoconazole/hydrocortisone in combination with dutasteride in men with CRPC. The largest previous study of ketoconazole (Cancer and Leukemia Group B 9583) analyzed responses to ketoconazole/hydrocortisone given concurrently or subsequent to antiandrogen withdrawal (response rates of 27% and 32%, respectively), so the current study was powered to determine whether the response was ,32% (23). Although response rates to ketoconazole in other smaller studies have ranged from 20% to 75% (22), the 56% response rate to KHAD indicates that 5α-reductase inhibition by dutasteride may enhance the response rate to ketoconazole/hydrocortisone. In contrast to the response rate, response durations in this study were markedly longer than those reported previously for ketoconazole/hydrocortisone. The median duration of response was 20 months, and 9 of the 32 responding patients had not yet progressed at the time of this ...
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