The European Commissions Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers (SCCNFP) evaluated safety data on Zinc Pyrithione. The Committee noted that Zinc Pyrithione has been used, as an anti-dandruff agent, for more than 60 years, in concentrations up to 1-2%. The acute as well as the subchronic toxicity was moderate to low, for both Zinc Pyrithione alone, or incorporated in market formulations.. In chronic toxicity experiments it was shown that an oral application of 500 microg/kg/day can be regarded as a dose that does not cause any adverse effects (NOAEL). No evidence of a carcinogenic response was seen when Zinc Pyrithione was applied topically up to 100 mg/kg/day or given orally up to 5 mg/kg/day in lifetime studies. The presence of Zinc Pyrithione did not impact upon the low irritation potential of the cosmetic formulations tested. The same observation was valid for a shampoo formulation investigated in a mucous membranes test. The appropriate ...
483794187 - EP 3231283 A1 2017-10-18 - BIOCIDE COMPOSITION COMPRISING ZINC PYRITHIONE AND A PYRROLE DERIVATIVE - The present invention is directed to a biocidal composition comprising a blend of zinc pyrithione and 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile (traloypryil) wherein said biocidal composition is copper free or low copper content. A coating composition comprising this biocidal composition as well as a method of coating a substrate and a coated wood, plastic, leather vinyl or metal substrate are also disclosed.[origin: US7893047B2] The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content.
Zinc pyrithione is a key chemical complex in dandruff shampoo. It has antibacterial and antifungal activities, along with resistance to ultraviolet radiation.
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