TY - JOUR. T1 - Junctional adhesion molecule-A is down-regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways. AU - Orlandella, Francesca Maria. AU - Mariniello, Raffaela Mariarosaria. AU - Iervolino, Paola Lucia Chiara. AU - Auletta, Luigi. AU - De Stefano, Anna Elisa. AU - Ugolini, Clara. AU - Greco, Adelaide. AU - Mirabelli, Peppino. AU - Pane, Katia. AU - Franzese, Monica. AU - Denaro, Maria. AU - Basolo, Fulvio. AU - Salvatore, Giuliana. PY - 2019/7. Y1 - 2019/7. N2 - Junctional adhesion molecule A (JAM-A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM-A as one of the genes mostly deregulated. The quantitative real-time polymerase chain reaction and immunohistochemistry analyses showed that downregulation ...

Shop Junctional adhesion molecule ELISA Kit, Recombinant Protein and Junctional adhesion molecule Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.

Junctional adhesion molecule-C (JAM-C) is an adhesion molecule involved in transendothelial migration of leukocytes. In this study, we examined JAM-C expression in the synovium and investigated the role of this molecule in two experimental mouse models of arthritis. JAM-C expression was investigated by reverse transcriptase-polymerase chain reaction and immunohistochemistry. The effects of a monoclonal anti-JAM-C antibody were assessed in antigen-induced arthritis (AIA) and K/BxN serum transfer-induced arthritis. JAM-C was expressed by synovial fibroblasts in the lining layer and associated with vessels in the sublining layer in human and mouse arthritic synovial tissue. In human tissue, JAM-C expression was increased in rheumatoid arthritis (RA) as compared to osteoarthritis synovial samples (12.7 ± 1.3 arbitrary units in RA versus 3.3 ± 1.1 in OA; p | 0.05). Treatment of mice with a monoclonal anti-JAM-C antibody decreased the severity of AIA. Neutrophil infiltration into inflamed joints was

Rationale: Besides their essential role in hemostasis, platelets also have functions in inflammation. In platelets, junctional adhesion molecule (JAM)-A was previously identified as an inhibitor of integrin αIIbβ3-mediated outside-in signaling and its genetic knockdown resulted in hyperreactivity. Objective: This gain-of-function was specifically exploited to investigate the role of platelet hyperreactivity in plaque development. Methods and Results:: JAM-A-deficient platelets showed increased aggregation and c-Src activation. Upon αIIbβ3 ligation, JAM-A was shown to be dephosphorylated, which could be prevented by PTPN1 inhibition. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe-/-) background were fed a high-fat diet. After up to 12 weeks of diet, trJAM-A-/- apoe-/- mice showed increased aortic plaque formation compared with trJAM-A+/+ apoe-/- controls and these differences were most evident at early time points. At 2 weeks, the plaques of the ...

ABSTRACT: INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. METHODS: MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link between the expression of JAM-A and β1-integrin, we examined activation of the β1-integrin regulator Rap1 GTPase in response to JAM-A knockdown or functional antagonism. To test whether JAM-A, Rap1 and β1-integrin lie in a linear pathway, we

Tight junctions (TJs) are electron‐dense structures connecting the lateral membranes of adjacent epithelial or endothelial cells. They exert adhesive properties and stabilize homophilic cell-cell binding. TJs serve a dual role in controlling paracellular permeability and in maintaining cell polarity. These junctional structures are particularly well developed in regions of the vascular tree where permeability has to be restricted, e.g. in the brain microvasculature and in large arteries (Mitic and Anderson, 1998; Stevenson and Keon, 1998; Dejana et al., 2000). Little is known about the molecular basis for the intercellular adhesion of TJs, despite their eminent role in organ functioning. Different transmembrane proteins have been found to be located specifically at TJs. Occludin and the claudin family belong to the class of tetra‐span transmembrane proteins (Furuse et al., 1993, 1998a,b). Occludin is dispensable for TJ organization and adhesive properties (Saitou et al., 1998). In contrast, ...

Sigma-Aldrich offers abstracts and full-text articles by [I Martìn-Padura, S Lostaglio, M Schneemann, L Williams, M Romano, P Fruscella, C Panzeri, A Stoppacciaro, L Ruco, A Villa, D Simmons, E Dejana].

A family of membrane glycoproteins localized to TIGHT JUNCTIONS that contain two extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail of variable length ...

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Purpose: The outer limiting membrane (OLM) is considered to play a role in maintaining the structure of the retina through mechanical strength. However, the observation of junction proteins located at the OLM and its barrier permeability properties may suggest that the OLM may be part of the retinal barrier. Material and methods: Normal and diabetic rat, monkey, and human retinas were used to analyze junction proteins at the OLM. Proteome analyses were performed using immunohistochemistry on sections and flat-mounted retinas and western blotting on protein extracts obtained from laser microdissection of the photoreceptor layers. Semi-thin and ultrastructure analyses were also reported. Results: In the rat retina, in the subapical region zonula occludens-1 (ZO-1), junction adhesion molecule (JAM), an atypical protein kinase C, is present and the OLM shows dense labeling of occludin, JAM, and ZO-1. The presence of occludin has been confirmed using western blot analysis of the microdissected OLM region. In

The brains circuitry is established by directed migration and synaptogenesis of neurons during development. Although neurons mature and migrate in specific patterns, little is known about how neurons exit their germinal zone niche. We found that cerebellar granule neuron germinal zone exit is regulated by proteasomal degradation of Pard3A by the Seven in Absentia homolog (Siah) E3 ubiquitin ligase. Pard3A gain-of-function and Siah loss-of-function induce precocious radial migration. Time-lapse imaging using a probe to measure neuronal cell contact reveals that Pard3A promotes adhesive interactions needed for germinal zone exit by recruiting the JAM-C epithelial tight junction adhesion molecule to the neuronal cell surface. Our findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche.. ...

GIOVANNI SOLIMANDO University of Bari Aldo Moro - Bari, Italy Born in Bari on 04/05/1985, he obtained his degree in Medicine and Surgery at the University of Bari on 22/07/2011 cum Laude and Committee Honor. He is currently Clinician Scientist Researcher and Assistant Professor at the Department of Biomedical Sciences and Human Oncology, Internal Medicine Unit Guido Baccelli Bari University Aldo Moro.. From October 2014 to October 2016, and from April 2018 to March 2019 he conducted a clinical and preclinical research stage at the Department of Internal Medicine, Medical Oncology and Hematology at the University of Würzburg, Germany, under the guidance of Prof. Hermann Einsele and Prof. Andreas Beilhack.. On 13/06/2017 he completed his post-Graduate in Internal Medicine at the Post Graduate Residency School of in Internal Medicine of the University of Bari cum Laude, discussing the thesis entitled Junctional adhesion molecule-A (JAM-A) as Prognostic Factor and New Therapeutic Target in ...

Tight junctions consist of a branching network of sealing strands of protein. Each strand is assembled from a series of transmembrane proteins(JAMs/Junctional Adhesion Molecules,Claudins and Occludin) embedded in plasma membranes. The extracellular domains join each other in tight junctions,whereas the intracellular domains are linked to peripheral membrane proteins,linking the transmembrane protein strands to actin cytoskeleton to create a functional network that plays a role in cellular processes. Each strand functions as an individual or linear barrie, therefore, the number of transmembrane protein strands is in relation with the degree of paracellular electrical resistance and impedance to solute flux in tight junctions[1]. Although other types of proteins are present at tight junctions, however, occludin and claudin are the major ones contributing to the structure of tight junctions. ...

Tight junctions consist of a branching network of sealing strands of protein. Each strand is assembled from a series of transmembrane proteins(JAMs/Junctional Adhesion Molecules,Claudins and Occludin) embedded in plasma membranes. The extracellular domains join each other in tight junctions,whereas the intracellular domains are linked to peripheral membrane proteins,linking the transmembrane protein strands to actin cytoskeleton to create a functional network that plays a role in cellular processes. Each strand functions as an individual or linear barrie, therefore, the number of transmembrane protein strands is in relation with the degree of paracellular electrical resistance and impedance to solute flux in tight junctions[1]. Although other types of proteins are present at tight junctions, however, occludin and claudin are the major ones contributing to the structure of tight junctions. ...

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321 (cluster of differentiation 321). Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene. F11 receptor has been shown to interact with MLLT4, CASK and Tight junction protein 1. GRCh38: Ensembl release 89: ENSG00000158769 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...

Junctional adhesion molecule (JAM), a subfamily of immunoglobulin superfamily (IgSF) with a couple of immunoglobulin domains, can act as regulator in homeostasis and inflammation of vertebrates. In the present study, a structural homolog of JAM-A (designated CgJAM-A-L) was screened out from oyster, Crassostrea gigas, through a search of JAM-A D1 domain (N-terminal Ig domain in JAM-A). The cDNA of ...

Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87 ...

Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain barrier (BBB) and then across the astrocytic glia limitans (GL). Factors secreted by reactive astrocytes open the BBB by disrupting endothelial tight junctions (TJs), but the mechanisms that control access across the GL are unknown. Here, we report that in inflammatory lesions, a second barrier composed of reactive astrocyte TJs of claudin 1 (CLDN1), CLDN4, and junctional adhesion molecule A (JAM-A) subunits is induced at the GL. In a human coculture model, CLDN4-deficient astrocytes were unable to control lymphocyte segregation. In models of CNS inflammation and MS, mice with astrocyte-specific Cldn4 deletion displayed exacerbated leukocyte and humoral infiltration, neuropathology, motor disability, and mortality. These findings identify a second inducible barrier to CNS entry ...

|strong|Rat anti Mouse CD321 antibody, clone H202-106|/strong| recognizes murine CD321, also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 274 amino acid ~32-4 1kDa single pass, typ…

Researchers from Freiburg discovered a novel mechanism that ensures obstacle-free protein traffic into the powerhouse of the cell

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THEME: It Knows Something You Dont The GMC Jam is a WILD game development contest run every 3 months by the GameMaker Community. This is the 37th such...

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Junctional Adhesion Molecule B / JAM2 Protein, Mouse, Recombinant (His Tag) | SinoBiological, 50464-M08H is produced in HEK293 Cells, with high purity. Animal free. Produced in house. Bulk in stock.

TY - JOUR. T1 - Erratum. T2 - Cutting edge: Combined treatment of TNF-α and IFN-γ causes redistribution of junctional adhesion molecule in human endothelial cells (Journal of Immunology (July 1)). AU - Yoshimura, A.. AU - Lien, E.. AU - Ingalls, R. R.. AU - Tuomanen, E.. AU - Dziarski, R.. AU - Golenbock, D.. PY - 1999/8/15. Y1 - 1999/8/15. UR - http://www.scopus.com/inward/record.url?scp=0033566730&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033566730&partnerID=8YFLogxK. M3 - Comment/debate. AN - SCOPUS:0033566730. VL - 163. SP - 2339. JO - Journal of Immunology. JF - Journal of Immunology. SN - 0022-1767. IS - 4. ER - ...

Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...

Copyright 2013 by the Massachusetts General Hospital. Some sections copyright 2008-2009 by The President and Fellows of Harvard College.. ...

Non-alcoholic fatty liver disease (NAFLD) is characterized by an abnormal amount of fat accumulation in the liver, specifically more than 5% fat by weight. Little is known about how the fat accumulates in the liver, but it has been found that intestinal permeability due to leaky tight junctions may be a contributing factor. Our lab studies junctional adhesion molecule-A (JAM-A), a protein located at the tight junctions of epithelial and endothelial cells. Through its ability to homodimerize at the apical part of the lateral membrane, JAM-A helps regulate the permeability and stability of the junction. This studys aim was to find what effect JAM-A has on the development of NAFLD. To analyze this relationship, groups of Jam-A (+/+) and Jam-A (-/-) mice were put on either a high-fat or low-fat diet for 20 weeks. During this time the mice were weighed every two weeks and blood samples were taken every four weeks. At the end of the 20 weeks, the mice were sacrificed and the livers and fat pads were ...

|jats:p| The junctional adhesion molecules (JAMs) have been recently described as interendothelial junctional molecules and as integrin ligands. Here we show that JAM-B and JAM-C undergo heterophilic interaction in cell-cell contacts and that JAM-C is recruited and stabilized in junctional complexes by JAM-B. In addition, soluble JAM-B dissociates soluble JAM-C homodimers to form JAM-B/JAM-C heterodimers. This suggests that the affinity of JAM-C monomers to form dimers is higher for JAM-B than for JAM-C. Using antibodies against JAM-C, the formation of JAM-B/JAM-C heterodimers can be abolished. This liberates JAM-C from its vascular binding partner JAM-B and makes it available on the apical side of vessels for interaction with its leukocyte counterreceptor α|jats:sub|M|/jats:sub|β|jats:sub|2|/jats:sub| integrin. We demonstrate that the modulation of JAM-C localization in junctional complexes is a new regulatory mechanism for α|jats:sub|M|/jats:sub|β|jats:sub|2|/jats:sub|-dependent adhesion of

The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen). Allele-specific transfected cells allowed us to demonstrate that an H61R point mutation is directly responsible for the formation of Mart epitopes. No difference in the adhesion capability between H61 and R61 homozygous neutrophils was observed. Functional analysis showed that anti-Mart inhibited Mac-1-dependent adhesion of neutrophils and monocytic U937 cells to fibrinogen, intercellular adhesion molecule-1 (ICAM-1), receptor for advanced glycation end product (RAGE), and glycoprotein Ibα but not to junctional adhesion molecule-C or urokinase plasminogen activator receptor (uPAR). Accordingly, anti-Mart blocked neutrophil and U937 cell adhesion to endothelial cells and platelet-leukocyte aggregate formation in whole blood under high shear. Other sera of anti-Mart

The blood-brain barrier is located at the level of the brain blood capillaries. There are several components of the barrier.. Tight junctions. A key component of the blood-brain barrier is the tight junctions between endothelial cells in central nervous system capillary vessels that restricts the passage of solutes. At the interface between blood and brain, endothelial cells and associated astrocytes (type of glia) are stitched together by structures called tight junctions. The tight junction is composed of smaller subunits, frequently dimers, that are transmembrane proteins such as occludin, claudins, junctional adhesion molecule (JAM), ESAM, and others. Each of these transmembrane proteins is anchored into the endothelial cells by another protein complex that includes zo-1 and associated proteins. The sealing together by tight junctions of the cells making up the walls of the vessels prevents water-soluble substances from freely passing between the cells and entering the fluid environment of ...

Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic plaque consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways ...

Rat anti Mouse JAM-C, clone CRAM-19 H36 recognizes mouse and human Junctional adhesion molecule C (JAM-C), also known as JAM-3 and, histor

Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic plaque consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways ...

Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. Long-term CagA delivery to polarized epithelia caused a disruption of the epithelial barrier function and dysplastic alterations in epithelial cell morphology. CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions.. ...

Rabbit polyclonal Junctional Adhesion Molecule C antibody validated for WB, ELISA and tested in Human. With 2 independent reviews. Immunogen corresponding to…

With regard to the JAM-1/1145 to 1385 transcript, we found that the level of this transcript in WKY varied between organs, whereas it was present in all of the organs analyzed in the SHR. Regarding the NTS, JAM-1/1145 to 1385 transcript was not detectable in WKY rats, whereas it was clearly present in the SHR. This indicates that, in the SHR, JAM-1 mRNA is spliced differently to WKY rats. In the NTS (and other brain areas studied), it appears to have an extended 3′UTR, a known feature present on many translationally efficient mRNAs. Alternatively, it is possible that the WKY transcripts lack 5′UTR because of differences in the transcription termination mechanism. When primers for the protein-coding part of JAM-1 mRNA were used (JAM-1/430 to 652), the transcript could be clearly identified in the NTS of WKY rats, although the level of expression was much lower than that of SHRs (see Figure 3). These results suggest that in normotensive WKY rats, a significant fraction of JAM-1 mRNA lacks ...

Results : Body weight, % body fat, fasting glucose, total cholesterol, and NEFA were increased with WD and wheat had no effect on these metabolic parameters. Serum C reactive protein and lipopolysaccharide binding protein were not changed by WD or wheat. WD decreased the SCFA, acetic acid, but adding Gallagher wheat to WD restored levels to control (PWD*Wheat, 0.05). No other SCFA were altered. Histological evaluation revealed reduced villi height (P, 0.05) and area (P, 0.05) in the jejunum with WD and wheat did not alter this response. Within the ileum, Gallagher increased villi area (P, 0.01) relative to control, but no other changes were noted. No effects of WD or wheat on villous atrophy or lymphocyte infiltration within the jejunum, ileum or colon were observed. Overall, gene expression of tight junction proteins was unaffected by WD or wheat, except for a reduction in junction adhesion molecule-3 (Jam3) by WD (P, 0.05). Within the ilial lamina propria, WD increased interferon-γ (IFNg) (P, ...

The blood brain barrier (BBB) is a specialized barrier that renders the environment of the central nervous system (CNS) separate from other compartments of the body. The unique environment provided by the BBB enables the specialized activity of neurons; BBB breakdown is the result of pathologic conditions and leads to further neuronal dysfunction. The unique requirements of the CNS require the BBB to limit the free exchange of some solutes that would be freely exchanged through other anatomic compartments. The restriction of solute transport limits how fluids can transfer across the BBB.. The BBB is formed by endothelial cells that line cerebral micro vessels. 1 It restricts the entry of many substances dissolved in blood because of specialized tight junctions (TJ) between adjacent endothelial cells. BBB TJ are maintained by the interaction of specialized cytoskeleton and linking proteins not expressed in other endothelium, examples include : Claudins, occludins, and junctional adhesion ...

Jellies, on … While there is a difference between jelly and jam, according to the U.S. Food and Drug Administration, jam and preserves are to be considered the same thing. Im a butcher, he says. I work with animals, the guy says to his date. The difference between jam and preserves is not in the type of fruit being used to make them. share. 8. Anonymous. The making of jam, jelly, or marmalade is straightforward and does not require lots of equipment or time. 10 Tips to Jam, Jelly, and Marmalade will guide you through. The jam color is a darker red. Whats the difference between a pregnant woman and a lightbulb? ... whats the difference between Chris Brown and Santa. The main difference between store-bought and homemade jams and jellies is the ingredient quality. Q: Why was the black baby crying? Jam is great for fillings and retains the fruit pulp, which contributes to its thick consistency. A: He had diarrhoea and thought he was melting. The main difference between Jelly and Jam is you ...

Fig. 1. Spa2p and Pea2p coimmunoprecipitate. Proteins were prepared from SPA2 PEA2::HA, SPA2 PEA2::myc, spa2Δ PEA2::HA, and spa2Δ PEA2::myc strains (Y2003, Y2004, Y2005, and Y2006, respectively) and immunoprecipitated with the indicated antibodies. The total yeast lysates and immunoprecipitates were analyzed on immunoblots. (A) Immunoblot probed with anti-HA MAb 16B12. The doublet at approximately 60 kDa corresponds to Pea2p::HA; it is observed in lysates from the SPA2 PEA2::HA strain but not the SPA2 PEA2::myc strain. The doublet is also observed in IP with anti-HA antibody or anti-Spa2p antiserum from theSPA2 PEA2::HA lysate (fifth and seventh lanes from the left). Anti-Spa2p antiserum failed to precipitate Pea2p::HA from the spa2Δ PEA2::HA lysate (last lane). +, presence of an allele (for PEA2::HA andPEA2::myc) or wild-type copy of the gene (for SPA2). (B) Immunoblot probed with affinity-purified anti-Spa2p antiserum. Spa2p migrates as a 190-kDa band that is not present in the spa2Δ ...

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Christmas came early for the hundreds of local residents who were invited to Holiday Jam at Antelope Valley Hospital (AVH) on December 17.

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I was in my fourth year in college when i first tasted gumamela jam. i was surprised when I heard of this jam, for all i know about gumamela is using it to make a solution to produce bubbles and a poultice to boils. Actually, i did it out of...

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Whittington: Nina, what are the important differences between trial and appellate mediations? What are some of the major obstacles to settlement at the appellate level? What are s...

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Words with JAM, the e-zine full of interviews and articles on writing, reading, libraries, the publishing industry and indie-publishing.

Ive made a lot of jam in my canning career. Between the years I logged as a kid helping my mom and all the many batches Ive made as an adult, Ive stirred and canned enough sweet preserves to fill a generously sized kiddie pool.. One thing Ive learned in those hours over a canning kettle is that jam making is a lot like life. Its not always going to be perfect, but you can almost always turn it into something useful and good.. When I teach jam making classes, one point I always emphasize is that you have two choices when you make a sweet preserve and it doesnt turn out as you intended. You can either stress about it and try to redo it (and even then, you still might not be able to exactly hit your texture target), or you can change your expectations and move on.. I belong firmly to the school of changed expectations. Some days, I have a hell of a time getting my jam to set. As someone who prefers a softer set to start out with, this means that those underset jars are essentially sauce or ...

Words with JAM, the e-zine full of interviews and articles on writing, reading, libraries, the publishing industry and indie-publishing.

No šodienas SIA SkaTVis analogās televīzijas tīklā uzsākam jauna kanāla FOX retranslāciju. Kompānija Fox International Channels sniedz iespēju baudīt...

CafeMom is a community where moms come together to get advice and support on topics like pregnancy, health, fashion, food, entertainment, and more.

seawal jam 7 pagi tadi, we all dah bertolak balik ke KB, dan jam 8.30 pagi sudah sampai ke SKKK 3 untuk melunasi kelas tambahan Atiqah ...