Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg(-1).day(-1)) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. Cardiac function at the base of the left ventricle was normal, but apical ejection fraction decreased from 90% to 31% and apical free wall thickening decreased by 94%, accompanied by increased fibrosis and inflammation. Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. Fatty acid transporter protein levels were 11
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The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog. Chronic intrarenal infusion of norepinephrine produced a biphasic curve of plasma renin activity (PRA) and a sustained 25 mm Hg increase in mean arterial pressure (MAP). The initial increase in PRA peaked at 3 hours, after which PRA returned to control levels. Alpha- or beta-adrenergic antagonists did not attenuate the initial rise in PRA. The PRA increased again after 48 hours of chronic intrarenal norepinephrine infusion and remained elevated thereafter. The second rise in PRA was increased by 30% with alpha-adrenergic blockade. Chronic intrarenal isoproterenol administration produced a similar increase in PRA, which peaked at 3-5 hours and then returned to control levels. In contrast to norepinephrine, chronic isoproterenol administration did not result in a second increase in PRA. At the end of the chronic isoproterenol infusion ...
Abstract. To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment. Three serum proteins--serum amyloid A (SAA), α-1-acid glycoprotein (A1AG), and apolipoprotein A-1 (Apo A1)--were consistently identified as changed and remained altered 72 h post dose in all three species post ISO treatment, indicating the potential of including these proteins in preclinical or clinical evaluation of drug-induced cardiac injury. Furthermore, proteomic analysis of heart tissue proteins following ISO treatment demonstrated detrimental effects on calcium signaling and energy generation in cardiac myocytes. It is worth noting that cardiac troponins were not identified in serum but were identified as altered in heart tissue lysate along with other cardiac-specific proteins. This strategy for cardiac biomarker discovery by proteomic screening of heart tissue proteins, ...
Isoproterenol Isoproterenol Systematic (IUPAC) name 4-[1-hydroxy-2-(1-methylethylamino) ethyl] benzene-1,2-diol Identifiers CAS number 7683-59-2 ATC code
OBJECTIVE: Myocardial damage induced by isoproterenol is believed to be secondary to increased oxygen demands on the heart. Our objective was to test an additional primary action of isoproterenol on tissue and mitochondrial oxidative metabolism and to compare these effects with the effects of other adrenergic agents in the presence of adrenergic inhibitors. DESIGN: Prospective, dose-response study. SETTING: Research laboratory at a university hospital. SUBJECTS: Fifty Sprague-Dawley female rats (200 to 350 g), slightly anesthetized with ether and divided into several groups. INTERVENTIONS: In 26 rats, the heart was removed, cut into fine slices (0.5-mm thickness), and placed in an ice-cold buffer. In 22 animals, the hearts were perfused in the Langendorff manner and chopped and processed for mitochondrial studies. MEASUREMENTS AND MAIN RESULTS: We determined the following: a) the direct in vitro effects of isoproterenol and related catecholamines on normal oxygen uptake using myocardial ...
Effect of chrysin on MAPKs protein expressions following isoproterenol-induced myocardial injury. (a) ERK½ and P-ERK½; (b) JNK and P-JNK; (c) p38 and P-p38 an
EFFECTS OF VASOPRESSIN AND ISOPRENALINE INFUSIONS ON THE DISTRIBUTION OF BLOOD FLOW IN THE INTESTINE; CRITERIA FOR THE VALIDITY OF MICROSPHERE STUDIES = EFFETS DES PERFUSIONS DE VASOPRESSINE ET DISOPRENALINE SUR LA REPARTITION DU FLUX SANGUIN DANS LINTESTIN; CRITERE DE VALIDITE POUR LETUDE PAR MICROSPHERESGREENWAY CV ...
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ISO 62:1999, ISO 75-2:1993, ISO 178:1993, ISO 179:1993, ISO 180:1993, ISO 293:1986, ISO 294-1:1996, ISO 306:1994, ISO 527-2:1993, ISO 527-4:1997, ISO 899-1:1993, ISO 1133:1997, ISO 1183:1987, ISO 1656:1996, ISO 2561:1974, ISO 2580-1, ISO 2818:1994, ISO 3167:1993, ISO 4581:1994, ISO 4589:1984, ISO 8256:1990, ISO 10350:1993, ISO 11357-2:1999, IEC 60093:1980, IEC 60112:1979, IEC 60243-1:1998, IEC 60250:1969, IEC 60296:1982, IEC 60695-11-10:1999, EN ISO 62:1999, EN ISO 75-2:1996, EN ISO 293:2003, EN ISO 294-1:1998, EN ISO 306:1996, EN ISO 527-2:1996, EN ISO 527-4:1997, EN ISO 1133:1999, EN ISO 2818:1996, EN ISO 8256:1996 ...
EN482, EN45544-2:1999, EN45544-3:1999, EN50270, EN60073, EN60068-2-6, ISO 3534-1, ISO 6141, ISO 6142, ISO 6143, ISO 6144, ISO 6145-1, ISO 6145-3, ISO 6145-4, ISO 6145-6, ISO 6147, ISO 6879:1995, ISO 7504 ...
ISO 3166-2:BR - стандарт ISO, який визначає геокоди для Бразилії. Він є частиною стандарту ISO 3166-2. Перша частина коду - код ISO 3166 для Бразилії (BR), друга частина - двоцифровий код регіону. ...
Iso Sunibutol in Malayalam - ന്റെ ഉപയോഗങ്ങൾ, ഡോസേജ്, പാർശ്വഫലങ്ങൾ, പ്രയോജനങ്ങൾ, പ്രതിപ്രവർത്തനങ്ങൾ, മുന്നറിയിപ്പ് എന്നിവ കണ്ടെത്തുക - Iso Sunibutol upayogangal, dossge, parswafalangal, prayojanangal, prathipravarthanangal, munnariyippu
CALORSTEAM 170°C ISO 6134- 1A, tubo vapore rinforzo tessile iso 6134-1a, applicazione mandata vapore saturo. particolarmente indicato per operazioni di lavaggio e sgrassamento di condutture, serbatoi,…
What is ISO 9001 and should i care? SAFER, SMARTER, GREENER 02 THE ROLE OF STANDARDS What is ISO 9001 and should I care? The Role of Standards The objective of any standard, whether it relates to the manufacture
The possible role of nitric oxide (NO) and vasoactive intestinal polypeptide on isoprenaline-induced relaxation of the mouse longitudinal gastric fundal strips precontracted with 5.4 X 10(-7)M carbachol was investigated. Isoprenaline (5 X 10(-7)M, 10(-6)M and 5 X 10(-6)M) produced a concentration-dependent relaxations. N-G-nitro L-arginine (10(-4)M) partly inhibited isoprenaline-induced relaxation. The inhibitory action of N-G-nitro L-arginine was reversed by 4 X 10(-4)M L-arginine but not by 4 X 10(-4)M D-arginine. N-G-nitro L-arginine (10(-4)M) did not affect the relaxation caused by sodium nitroprusside (10(-6)M). Vasoactive intestinal polypeptide antibody 7913 (1:160 dilution) partly inhibited isoprenaline-induced relaxation, This inhibition was greater on the response to the higher isoprenaline concentration (5 X 10(-6)M) than to the lower concentration (10(-6)M). The combination of vasoactive intestinal polypeptide antibody and N-G-nitro L-arginine significantly enhanced the inhibition on ...
TY - JOUR. T1 - Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.. AU - Emala, C.. AU - Black, C.. AU - Curry, C.. AU - Levine, M. A.. AU - Hirshman, C. A.. PY - 1993/6. Y1 - 1993/6. N2 - Previous studies in human asthmatics have suggested a defect in the beta-adrenergic pathway leading to cyclic adenosine monophosphate (cAMP) generation. Although these studies have suggested normal or increased numbers of beta-adrenergic receptors, limitations in the quantity of tissue available have not allowed further delineation of the biochemical or molecular mechanisms of human asthma. The basenji-greyhound (BG) dog model of nonspecific airway hyperreactivity displays similarities to human asthma, and altered functional response to beta-adrenergic agonists has been previously shown in airway tissue from this model. We have now correlated this functional impairment in beta-adrenergic response with a ...
TY - JOUR. T1 - Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus. AU - Paietta, Elisabeth M.. AU - Schwarzmeier, J. D.. AU - Simbruner, G.. AU - Latzka, U.. AU - Lubec, G.. PY - 1981. Y1 - 1981. N2 - Using the adenylate cyclase assay after Ross the authors examined hormone sensitivity of isolated glomerular cells. cAMP production was increased 1.3-1.6-fold by stimulation with isoproterenol, 1.5-1.8 times by prostaglandin E 1 and 1.4-1.5 times by histamine. The isoproterenol reaction could be completely inhibited by propranolol, the histamine effect was abolished by the H2-blocking agent cimetidine. As a control the authors applied sodium fluoride, which directly activates the catalytic adenylate cyclase unit, increasing the activity 1.8-2.7 times (depending on the method of homogenization). These findings could reflect some physiological or pathophysiological implications, which are discussed.. AB - Using the adenylate cyclase ...
Isoproterenol infusion during cardiac catheterization as a simulator of exercise was evaluated with hemodynamic studies in children with pulmonary (15) or aortic (8) valve stenosis. Cardiac function was monitored during rest, mild exercise and isoproterenol infusion. Similar heart rates were maintained in both procedures. Peak pulmonary and aortic valve gradients as well as right and left ventricular dp/dt/p were significantly higher and cardiac index significantly lower with isoproterenol as compared to exercise. Isoproterenol induced a significantly greater decrease in systemic vascular resistance, and systemic blood pressure than did exercise. Left ventricular systolic pressure rose to similar levels and this resulted in substantially higher peak aortic gradients with isoproterenol. A consistent correlation was observed for peak valvular gradients measured during exercise and isoproterenol in both groups of patients. Accordingly, regression equations were obtained allowing reasonably accurate ...
This study investigates the hypothesis that inflammatory cytokines, interleukin (IL)-1alpha IL-1beta, and tumor necrosis factor (TNF), influence cardiac function by affecting calcium homeostasis and that this effect is mediated by the beta-adrenergic-adenylate cyclase system. After 4 days in culture, neonatal rat ventricular myocytes were treated with cytokines (10 ng/ml) for short (2 h) or longer (18 h) times. Myocyte calcium, contractility, and adenylate cyclase were measured under each condition. Anticipated stepwise increases in adenylate cyclase and intracellular calcium were found in controls (non-cytokine-treated) with 10(-7) M isoproterenol, 10(-7) M isoproterenol + 0.1 mM guanosine triphosphate, and 10(-9) M forskolin. Cells in the presence of cytokine for 2 h show increased basal calcium levels but no changes in adenylate cyclase activities, and isoproterenol fails to elevate adenylate cyclase levels or affect contractile shortening. After long-term treatment with IL-1beta or TNF, but ...
Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine hydrochloride produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.. In patients with depressed cardiac function, both dobutamine hydrochloride and isoproterenol increase the cardiac output to a similar degree. In the case of dobutamine hydrochloride, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. In contrast, isoproterenol increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or ...
Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells.
TY - JOUR. T1 - Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. AU - Berrettini, Wade H.. AU - Bardakjian, Josiane. AU - Cappellari, Charles B.. AU - Barnett, Arthur L.. AU - Albright, Allen. AU - Nurnberger, John I.. AU - Gershon, Elliot S.. PY - 1987/12. Y1 - 1987/12. N2 - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.. AB - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine ...
To the editor: Drs. Berger and Winsor comment in their recent letter (1) on Shims and Williams paper evaluating the safety of isoproterenol (2). They report their own findings (3, 4) that isoproterenol in similar therapeutic doses resulted in ischemic ECG changes.. Shim and Williams administered overdosages of isoproterenol from pressurized aerosol containers to asthmatic patients without heart disease. Puffs of 100 µg were given in repeated doses of either two puffs every 5 min or five to 10 puffs every 20 min. There were no arrhythmias or changes in ST segments. The authors concluded that the drug is safe ...
Background Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. We hypothesized that experimental ...
Yabana H.; Sugimoto T.; Nagao T., 1990: Demonstration of beta 2 mediated positive chronotropic action of isoproterenol in anesthetized dogs comparison with selective beta 1 agonist t 0509
Studies were directed to measurement of hyperlactic acidemia and hyperglycemia induced by various catecholamines in anesthetized rats and conscious dogs. A family of compounds structurally related to the beta adrenergic blocking agent sotalol (MJ 1999) was investigated for potency with respect to inhibition of the aforementioned metabolic responses. Data were correlated with attenuation of isoproterenol-induced relaxation of isolated guinea-pig tracheal smooth muscle. Increasing the alkyl chain length of the p-alkylsulfonamido moiety on the benzene ring reduced beta adrenergic blocking activity, as did increasing the size of the N-alkyl group on the amino nitrogen up to n-heptyl. Branched N-alkyl groups (e.g., sec.-and tert.-butyl) increased potency. Alpha,. alkyl substitution of the ethanol moiety variably enhanced or lessened beta blocking activity. For the series of compounds, in general, diminution of epinephrine-induced metabolic responses in vivo correlated well with antagonism of ...
The purpose of this study was to investigate the mechanism of histamines H1-receptor-mediated positive inotropic effect, a response which is not associated with an increase in cyclic AMP levels. We found that the concentration-response curve for the positive inotropic effect of histamine on cavian left atrium was similar to that of the alpha-1 agonist phenylephrine, in terms of slope and maximum response. Additionally, both agents slightly prolonged time-to-peak tension and relaxation times. In contrast, the concentration-response relationship for the beta-agonist isoproterenol, whose positive inotropic effect is mediated by an increase in cyclic AMP, had a steeper slope and a much greater maximum. Furthermore, isoproterenol abbreviated time-to-peak tension and relaxation times. As reported previously for alpha-1 agonists, the development of the contractile response to a submaximal histamine concentration (10 microM) coincided with a rapid increase in left atrial tissue levels of inositol ...
Postprandial release of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) from L cells results from both nutrient transit in the ileal lumen and neural drive of endocrine cells. The adrenosympathetic system and its effectors have been shown to induce secretion of L cells in vivo or in vitro. Because these transmitters act through three receptors, beta, alpha1, alpha2, coupled to different intracellular pathways, we evaluated the responses of L cells to specific agonists, using the model of isolated vascularly perfused rat ileum. General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin. Blockade of alpha2-receptors with idazoxan (10(-8) M) did not alter epinephrine-induced peptide secretion. The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min ...
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Cathecholamines increase heart rate and contraction force. This effect is mainly mediated by their interaction with the β-adrenergic receptor...
BioAssay record AID 218832 submitted by ChEMBL: Tested for beta-1-adrenergic blocking effect by measuring the ability to inhibit the positive inotropic effect of isoproterenol on the isolated right atrium of guinea pigs.
Isoprenaline - Get up-to-date information on Isoprenaline side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Isoprenaline
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a…
The toxicity of a chemical is not a colligative property of a substance; it is a function of the susceptibility of the organism upon which the chemical acts. The susceptibility is determined by the...
Given the above specifications, many computers will not be able to update because they do not meet the minimum hardware requirements for Windows 11. They will not be able to at least officially, but on their own. If the user decides download the Windows 11 ISO on your own and install it it is free to do so. The problem? Some.. ...
EN 482:1994, EN 45544-1, EN 45544-2, EN 45544-3, EN 689:1995, EN 50014, EN 50015, EN 50016, EN 50017, EN 50018, EN 50019, EN 50020, EN 50028, EN 50039, EN 50054, EN 50073, EN 50270, EN 60079-10:1996, IEC 60079-10:1995, ISO 3534-1, ISO 6141:1984, ISO 6142:1981, ISO 6143:1981, ISO 6144:1981, ISO 6145-1:1986, ISO 6145-3:1986, ISO 6145-4:1986, ISO 6145-6:1986, ISO 6147:1979, ISO 6349:1995, ISO 6879:1996, ISO 7504:1984 ...
臺灣銀行獲BSI正式頒發ISO 20000-1:2005資訊服務管理系統驗證證書,證明該行資訊服務管理系統經得起國際標準的考驗,而高品質的管理作業也強化該行的核心競爭能力。
The interaction of the renin-angiotensin system and the sympathetic nervous system in patients with congestive heart failure is not well understood. We tested the hypothesis that angiotensin-converting enzyme inhibitors can resensitize the beta-adrenergic receptor system. Guinea pigs were given captopril, isoproterenol, or both for 2 weeks. At death, cardiac sarcolemmal and light vesicle fractions and intact mononuclear leukocytes were prepared. Captopril treatment led to an up-regulation of cardiac beta 1- but not mononuclear leukocyte beta 2-adrenergic receptors and an increase in isoproterenol-stimulated adenylate cyclase activity in the heart. Animals treated with isoproterenol developed cardiac hypertrophy, had increased plasma norepinephrine levels, and had a decreased number and responsiveness of both cardiac and mononuclear leukocyte beta-adrenergic receptors. Concomitant treatment with captopril attenuated alterations of heart weight, plasma norepinephrine levels, and cardiac ...
The effects of the simple bioactive lipid mediator lysophosphatidic acid (LPA) on cAMP accumulation were investigated in cultured human airway smooth muscle cells (ASMC). Pretreatment of cells with LPA induced an increase in subsequent stimulation of cAMP accumulation by forskolin and by isoproterenol. When included during the assay of cAMP accumulation rather than as a pretreatment, LPA inhibited forskolin stimulation but enhanced isoproterenol stimulation. Both effects of LPA on forskolin stimulation were completely blocked by pertussis toxin treatment, whereas the effects on isoproterenol stimulation appeared relatively insensitive to pertussis toxin. The protein kinase C activator phorbol-12-myristate-13-acetate (PMA) sensitized forskolin stimulation to a similar extent as did LPA, and the combination of LPA plus PMA caused markedly more sensitization than either agent alone. In contrast, PMA inhibited isoproterenol stimulation and markedly decreased the sensitization induced by LPA. Serum ...
Background- Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important regulator of innate immunity, the precise pathway of TLR4 mediated cardiac complications is yet to be established. Therefore, the primary objective of the present study was to find the role of TLR4 in cardiac hypertrophy and the molecular mechanism thereof. Methods- Cardiac hypertrophy was induced with administration of isoproterenol (5mg/kg/day, sc). TLR4 receptor inhibitor RS-LPS (lipopolysaccharide from the photosynthetic bacterium Rhodobacter sphaeroides; 5 microgram/day) and agonist LPS (Lipopolysaccharide from Escherichia coli; 3.12 microgram/day) were administered through osmotic pump along with isoproterenol. Cardiac hypertrophy as well as oxidative stress and mitochondrial
The incorporation of 32Pi into phospholamban, troponin I, phosphatidylinositols, and inositol trisphosphates was studied in Langendorff-perfused guinea pig hearts stimulated with isoproterenol. Hearts were perfused with Krebs-Henseleit buffer containing [32P]Pk and freeze-clamped at different times during the positive inotropic response. Exposure of the hearts to 0.1 microM isoproterenol for up to 1 minute was associated with significant (up to threefold) increases in phospholamban and troponin I phosphorylation, but there was no significant increase in 32P incorporation into phospholipids. However, longer exposure (2 minutes or more) to isoproterenol was associated with increases in the degree of 32P labeling of phosphatidylinositols and phosphatidic acid. Examination of 32P labeling of inositol trisphosphates in the same hearts revealed that the radioactivity associated with these compounds decreased with time. The decreases were significant at times of exposure of 2 minutes or longer to ...
Seventeen patients (16 men and I woman) were challenged with isoproterenol after their initially inducible sustained ventricular tachyarrhythmia (monomorphic tachycardia in 14 patients and fibrillation in 3) was completely suppressed by class I antiarrhythmic drugs. Coronary artery disease was documented in 11 patients, dilated cardiomyopathy in 2 and no structural heart disease in the remaining 4 patients. The initial presentation was aborted sudden cardiac death (five patients), syncope (eight patients) and symptomatic nonsustained ventricular tachycardia (four patients). The antiarrhythmic drug that rendered the initial ventricular tachyarrhythmias noninducible was class IA in 11 cases, class IC in 5 and combined class IA and IB in 1.. The original ventricular tachyarrhythmia became reinducible in 10 patients (group A) and remained noninducible in 7 patients (group B) after isoproterenol infusion at a rate necessary to achieve a 20% increase in heart rate. Despite the results of isoproterenol ...
TY - JOUR. T1 - Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats. AU - Sangeetha, T.. AU - Quine, S. Darlin. PY - 2008/7/1. Y1 - 2008/7/1. N2 - The antihyperlipidemic, antilipoperoxidative and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats were reported previously. The present study was undertaken to evaluate the preventive role of SACS on some biochemical parameters, glycoproteins and hematology in experimentally induced myocardial infarction in rats. Myocardial infarction was induced in rats by subcutaneous injection of isoproterenol (ISO) (150 mg kg -1) at an interval of 24 h for 2 days. ISO-treated rats showed a significant increase in the levels of serum iron, uric acid and blood glucose, Na+ and Ca2+ in the heart and a significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K+ and ...
The chronic administration of the β-adrenoreceptor agonist isoproterenol (IsoP) is used in animals to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines. Time-dependent changes in myocardial blood flow (MBF), morphological and functional parameters were assessed in rats in vivo using multimodal cardiac MRI. Energy metabolism, oxidative stress and the nitric oxide (NO) pathway were evaluated in isolated perfused rat hearts following 7 days of treatment. Male Wistar rats were infused for 7 days with IsoP or vehicle using osmotic pumps. Cine-MRI and arterial spin labeling were used to determine left ventricular morphology, function and MBF at days 1, 2 and 7 after pump implantation. Isolated hearts were then perfused, and high-energy phosphate compounds and intracellular pH were followed using ³¹P MRS with simultaneous measurement of contractile function. Total creatine and malondialdehyde (MDA) contents were measured by high
TY - JOUR. T1 - Alpha-1-adrenergic receptors in heart failure. T2 - The adaptive arm of the cardiac response to chronic catecholamine stimulation. AU - Jensen, Brian C.. AU - OConnell, Timothy D.. AU - Simpson, Paul C.. PY - 2014/4. Y1 - 2014/4. N2 - Alpha-1-adrenergic receptors (ARs) are G protein-coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. There are far fewer alpha-1-ARs than beta-ARs in the nonfailing heart, but their abundance is maintained or increased in the setting of heart failure, which is characterized by pronounced chronic elevation of catecholamines and beta-AR dysfunction. Decades of evidence from gain and loss-of-function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1-ARs to include physiological hypertrophy, positive inotropy, ischemic preconditioning, and ...
The myocardial potassium uptake during intracoronary isoproterenol stimulation was characterized in 12 anesthetized pigs. The beta-receptor subtype specificity and the effect of adenylate cyclase activation were determined. Potassium concentrations were continuously recorded by PVC-valinomycin minielectrodes in the left atrial cavity and in coronary sinus blood diverted through a shunt to the right atrium. The difference in potassium concentration between the left atrial cavity and coronary sinus, and the accumulated myocardial potassium uptake were calculated after computerized data sampling. By intracoronary drug infusion, changes in heart rate and systemic effects were minimized. Isoproterenol (0.6-0.8 microgram/min), a nonspecific beta-agonist, reduced coronary sinus potassium concentration transiently to a nadir of 0.28 (0.15-0.43) mM (median and 95% confidence interval) below control values (n = 12). The potassium uptake, which amounted to 140 (79-202) mumol/100 g tissue, corresponding to ...
TY - THES. T1 - Disease modifiers in hypertrophic cardiomyopathy. T2 - Interaction between calcium, titin and beta-adrenergic receptor stimulation. AU - Najafi, A.. PY - 2018. Y1 - 2018. KW - Hypertrophic cardiomyopathy; Heart disease; Heart failure. M3 - PhD Thesis - Research VU, graduation VU. ER - ...
DESENSITIZATION OF TURKEY ERYTHROCYTE ADENYLATE-CYCLASE - BETA-ADRENERGIC-RECEPTOR PHOSPHORYLATION IS CORRELATED WITH ATTENUATION OF ADENYLATE-CYCLASE ACTIVITY
Define isoprenaline. isoprenaline synonyms, isoprenaline pronunciation, isoprenaline translation, English dictionary definition of isoprenaline. or n drugs a compound that is a derivative of adrenaline and that is used to treat asthma and bronchial conditions. Formula: C11H17NO3
TY - JOUR. T1 - The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine. AU - Devous, M. D.. AU - Jones, C. E.. PY - 1978/1/1. Y1 - 1978/1/1. UR - http://www.scopus.com/inward/record.url?scp=0018249718&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018249718&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018249718. VL - 21. JO - The Physiologist. JF - The Physiologist. SN - 0031-9376. IS - 4. ER - ...
Synonyms for adrenergic drug in Free Thesaurus. Antonyms for adrenergic drug. 1 synonym for adrenergic drug: adrenergic. What are synonyms for adrenergic drug?
Lipomas are benign, non-cancerous fatty tumors that occur under the skin and make a bump that can be easily felt and often seen. The current treatment for lipomas is surgery. Isoproterenol, a medication used for the treatment of asthma and approved for injection under the skin, is known to cause fat cells to give up their fat. The fat cells become resistant to isoproterenol with repeated use. Prednisolone, a synthetic cortisone medication used to treat immune problems like allergy and approved for injection under the skin, keeps the fat cells from becoming resistant to isoproterenol. It is not known, if the fat cells in lipomas act like other fat cells or if the combination of isoproterenol and prednisolone injections would shrink lipomas without surgery. This study is designed to test this possibility.. Subjects will have a screening visit, 2 microdialysis visits a week apart, 20 treatment visits 5 days per week for 4 weeks, and up to 12 follow-up visits a year after treatment visits. During ...
A Moderate Drug Interaction exists between isoproterenol and propranolol. View detailed information regarding this drug interaction.
cAMP is a well studied second messenger that is ubiquitously expressed in mammals. It conducts its function by activating its downstream effectors: protein kinase A (PKA), exchange proteins regulated by cAMP (EPAC) and cyclic nucleotide gated ion-channels. The sole mechanism to inactivate cAMP is through degradation via cyclic-phosphodiesterases (PDEs). The PDEs, especially PDE4s, are involved in many diseases including asthma, chronic obstructive pulmonary disease (COPD) and depression. Therefore, PDEs have been a consistently popular research subject for decades and pharmaceutical companies have devoted considerable effort in developing PDE inhibitors. β-arrestin interacts with PDE4D5 and is a multifunctional protein that plays pivotal roles in signal transduction. It functions as an adaptor protein in the c-Raf/MEK/ERK cascade by interacting with c-Raf and ERK ...
Anti-Obesity Agents: Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
Effect of intense exercise training on myocardial basal function and responsiveness to isoproterenol stimulation. Isoproterenol was infused to isolated hearts o
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008 ...
During further development the ability of sarcoplasmic reticulum to accumulate Ca2+ increases and there is a progressive maturation of Ca2+ release from the
Representative traces and indicate data showing the response of shortening (expressed as a % of resting cell size) to selective stimulation of b1-AR with one hundred nM isoproterenol (Iso) in the existence of 100 nM ICI 118,551. C, D. Representative traces and suggest information of the response of [Ca2+]i transient amplitude to selective b1-AR stimulation. Knowledge are from 200 myocytes from 7 hearts. E, F, G. Agent traces and suggest information of the reaction of ICa,L to selective stimulation of b1-AR with 10 nM Iso in the presence of ICI 118, 551 (ICI). n = six myocytes from three hearts. P,.05, Students t-take a look at. doi:ten.1371/journal.pone.0106905.g005 In standard, the results of simvastatin on basal and b-AR stimulated grownup myocyte perform are quite comparable to individuals we have noted beforehand when caveolae are disrupted with MBCD, suggesting that simvastatin is operating by way of cholesterol-dependent (caveolar) pathways. Nonetheless, presented the human body of ...
Isoprenaline hydrochloride is a beta-adrenergic agonist which has a powerful stimulant action on the heart, increasing cardiac output and heart rate. It also increases blood flow to the limbs and extremities. Isoprenaline is a sympathomimetic medicine that dilates the small air passages in the lungs and improves the transmission of electrical signals in the heart. This medicine is given intravenously as an emergency treatment for serious heart disorders.
Adrenergic drugs stimulate your sympathetic nervous system. Find out how they treat different conditions by targeting different receptors in this system.
Change in other NPD measures from baseline and Days 4, 7, and 14 to include baseline PD, change in amiloride, low chloride, and low chloride plus isoproterenol ...
Clonidine (10(-7) M), an alpha2-agonist, induced a moderate and delayed increase of GLP-1 and PYY but abolished the isoproterenol-induced peptide secretion ...
Read on to learn about their history, what they entail, and their impact on the businesses that employ them.ISO 9001. By far the most popular family is that of ISO 9000. … ISO 14001. ISO 14000 is a family of standards relating to the environment. … ISO 27000. … ISO 22000. … ISO 50001. … ISO/TS 16949. … ISO 13485. … ISO 31000.More items…• ...
Futher questions on ISO 14001 and ISO 9001 integration I have read through the various threads on ISO 14001 and ISO 9001 integration. From what I can see...
Iso Active je instantný iontový nápoj vo forme dobre rozpustného prášku. Pomôže doplniť dôležité látky, ktoré telo pri športe stráca potom. V zložení tak
Laboratorul BIOEVAL desfasoara activitati in domeniul evaluarii sigurantei utilizarii materialelor si dispozitivelor medicale conform seriei de documente ISO 10993