We have previously reported strategies for Escherichia coli production of recombinant immunogens fused to hydrophobic peptides or lipid tags to improve their capacity to be incorporated into an adjuvant formulation, e.g., immunostimulating complexes (iscoms). Recently, we also explored the strong interaction between biotin and streptavidin to achieve iscom association of recombinant immunogens. Plasmodium falciparum, Toxoplasma gondii and Neospora caninum antigens have served as model immunogens in the different studies. Generated fusion proteins have been found to be successfully incorporated into iscoms and high-titer antigen-specific antibody responses have been obtained upon immunization of mice. We believe that the different concepts presented, utilizing either hydrophobic peptide or lipid tags, or the recently explored biotin-streptavidin principle, offer convenient methods to achieve efficient adjuvant incorporation of recombinant immunogens.. ...

Here you get to know what are ISCOMS (Immune Stimulatory Complexes)? ACTION with detailed and pictorial explanation of the ISCOMs action

Since surgery currently provides the best chance for survival of pancreatic cancer, any research that helps to move more patients toward that goal is exciting, said lead author David C. Linehan, director of clinical operations at Wilmot and Chair of Surgery at the University of Rochester Medical Center.. This study is also significant, Linehan said, because there is no consensus on the best way to treat locally advanced pancreatic cancer that cannot immediately be removed. The median five-year survival rate is less than 5 percent. Doctors typically use chemotherapy and combinations of other therapies to try to control the disease.. Linehans small, phase 1b study enrolled 47 patients with locally advanced pancreatic ductal adenocarcinoma, the most common type. Most patients received an experimental immune-stimulating drug (a pill) developed by Pfizer Inc. known as PF-04136309, plus a standard four-drug chemotherapy regimen. A few received chemotherapy alone. The majority of the patients who ...

Injecting immune cell stimulants directly into a tumour could help the immune system spot and attack cancer cells, according to new research in mice.

Purified proteins are often poorly immunogenic and in such cases the induction of primary immune responses requires use of an adjuvant

In this study, we evaluated the efficacy of human adjuvant vector cells for use as cancer vaccines in dogs and immunodeficient mice using human materials. We used allogeneic human cells, the CD1d-HEK293 cell line loaded α-GalCer and transfected with mRNA-encoding tumor antigen as artificial adjuvant vector cells. Our approach uses antigen-expressing vector cells expressing 2 antigens, which allows for host DC cross-presentation of tumor antigens to naïve T cells while simultaneously presenting iNKT cell ligand to iNKT cells (34, 35). This strategy induces activation of tumor antigen-specific CTLs as well as iNKT cells. An additional benefit of this strategy is the flexibility of mRNA transduction, which uses mRNA derived from tumor cell lines or tumors from third party patients and encodes for tumor antigens without the need for HLA matching. Furthermore, we have found in other studies that transfer of allogeneic cells expressing cell-associated tumor antigen and iNKT cell ligand induces not ...

Your future at the UMCG. If you want to know more about PhD positions and research at the University Medical Center Groningen (UMCG), come to Your Future at the UMCG! The director of the Graduate School of Medical Sciences (GSMS) Martin J. Smit, PhD, will give a detailed presentation about the possibilities of doing research and the opportunities to gain a PhD position at the UMCG. The session will be concluded with a personal story from a PhD graduate.. Science Elective. The Science Elective will be held between the masterclasses. Besides the educational parts of the day, the Science Electives are meant to be a fun part of the day! You can choose between a patient lecture, a debate, thinking critically about the approach of House MD in two different sessions.. In the patient lecture, a patient who has suffered from psychosis will tell you everything you want to know about the disease and the influence it has on the patients life, together with Frank D. van Es MD.. This year, the debate will be ...

Like a tourist without a map, tumor-fighting T cells have a hard time finding their destination without directions. According to Clark et al. (page 2221), dismantling these directions helps skin cancer cells hide from killer T cells.. To enter the skin, T cells must grab on to the adhesive molecule E-selectin, which is expressed on the endothelial cells lining blood vessels in the skin. The authors now find that many of the vessels in skin cancer lesions lack E-selectin, causing beneficial T cells to pass by unaware. The tumors were instead populated by suppressive regulatory (T reg) cells, perhaps coaxed in by the tumor to safeguard against killer cells that somehow gain access. Both tactics have also been seen in other types of human cancer.. Reversing the suppressive effect of T reg cells is one of the beneficial effects of topical immune-stimulating drugs like the TLR agonist imiquimod, which is effective in treating certain types of skin cancer. Indeed, Clark et al. found that imiquimod ...

Salmonellen_in_Tumor.jpg Scientists have made progress in using bacteria as a therapeutic tool in treating cancer. Researchers at the Helmholtz Centre for Infection Research in Braunschweig were able to demonstrate that a genetically modified Salmonella typhimurium colonized tumor cells, and that certain genes may be activated remotely, in this case, by the applicaiton of L-arabinose.. Applying L-arabinose, after the salmonella bacteria have infected mice and migrated to the cancerous tissue, activates these genes. Thus far, Weiss and Loessner used genes that encode light emitting proteins. If the mice are given a dose of the sugar, bacteria that have colonized the tumor fluoresce, such that the location and size of the tumor can be analyzed. Theoretically, instead of emitting light, the bacteria in future could be triggered to produce and deliver cancer-fighting medication inside the tumor. Alternatively, they could also deliver immune-stimulating substances that would mark the tumor for the ...

LIGHT is an immune-stimulating chemical messenger previously found to have low levels of expression in patients with colon cancer metastases.

In order to ensure the best results from tissue engineering treatment strategies, the cells used need to be characterized in detail, and in vitro cell expansion protocols need to be optimalized. In his thesis, cand. scient Aboulghassem Shahdadfar has studied three cell populations with considerable potential in protocols in regenerative medicine. He identified mesenchymal stem cells (MSC) in adipose tissue, and defined their phenotype and gene expression. He showed that these cells could differentiate to several different lineages, and characterized the changes in gene expression induced in these cells by in vitro cell culture. Another population of MSC is found in the bone marrow. Using these cells, Shahdadfar showed that serum from the bone marrow donor could be used for in vitro cell expansion in stead of fetal calf serum, thus avoiding the risk of transfer of zoonoses and immune-stimulating xenogeneic proteins. The cells thus obtained seemed also to be more genetically stable ...

basic principle of treatment of sepsis is based on troubleshooting foci of infection.Their reorganization carried out by a wide opening and a thorough nekroektomii.Additionally, the wound was treated with low-frequency ultrasound, antiseptics (Dioksidin Dimeksidin, etc.), surfactants (Hlorgeksin ) and proteolytic enzymes ( Trypsin Profezim et al.).. patient selected maximum possible doses of antibiotics, depending on the specific pathogen, such as staphylococcal septicemia used drugs Fuzidin and Refampitsin.Increased resistance stimulated by vitamin therapy and immune-stimulating drugs, and aggressive enzymes are suppressed by administration of inhibitors Contrycal or Gordoks.. Detoxification is performed by using a large number of protein drugs and intravenous glucose solution.. order to eliminate manifestations of hypovolemia (decrease in blood volume) preferred drugs Polidez, Poliglyumasol etc.in combination with desagregants xantinol nicotinate or ...

Antibiotic resistance is a growing threat in bacterial pneumonia. While immune-stimulating treatments can help the body fight the invaders, they can also cause inflammation that damages and weakens lung tissue. But new research suggests a way to enhance bacterial killing without the inflammation.

Well, this super healthy fruit (lemon) is loaded with many healthy nutrients, such as: calcium, potassium, magnesium, iron and Vitamin A, Vitamin C and Vitamin B complex, as well as pectin fibers, proteins and carbohydrates. The citric acid of lemon has strong antibacterial and anti-viral power and it also has immune-stimulating powers that help keep us healthy.. And mow, lets get back to the reasons why you should drink lemon water in the morning, on empty stomach. In this article we are going to show you 10 good reasons, why you should drink lemon water in the morning, on empty stomach.. ...

CM-Glucan Granulate is a natural yeast polysaccharide featuring immune-stimulating properties. It increases the skins self-protecting capacity and accelerates skin recovery.

Broncho munal 7mg N10 - - Respiratory system - The drug Broncho-munal is an immunostimulating, combined agent, intended for oral administration. Assign a drug to facilitate the course of respirator

Researchers at the Center for Cognition and Sociality, within the Institute for Basic Science (IBS), Gwangju Institute of Science and Technology (GIST), and Korea Institute of Science and Technology (KIST) have discovered a new mechanism to explain the effects of subcortical strokes and a new possible therapeutic approach.. Every year, 15 million people worldwide suffer from stroke according to the World Health Organization. Five million of those die and another five million are permanently disabled. Stroke is one of the most commonly reported causes of death and greatly impacts patients quality of life. However, despite its prevalence and negative impact, there are no direct medical treatments for recovery after stroke and patients rely on rehabilitation.. A stroke occurs when the blood supply is interrupted or reduced due to bleeding or occlusion of blood vessels in some part of the brain. Brain cells subsequently begin to die within minutes, causing a regional brain damage. In addition, the ...

Recent posts by Lloyd at MacPerformanceGuide.com, WindInMyFace.com:. 2021-09-15 What is a Vaccine? Redefining it for COVID Messaging. 2021-09-15 Science.org: A grim warning from Israel: Vaccination blunts, but does not defeat Delta - Vacci…. 2021-09-15 Israel Sees Record-High Daily Infections, Hints Fourth Vaccine Dose. 2021-09-15 COVID vaccines ===, Immune-Stimulating Prophylactic Therapeutics?. 2021-09-14 Why Mass Vaccinations Prolong & Make Epidemics Deadlier: Vaccines Expert Calls Out Governmen…. 2021-09-14 WSJ: Hearing too Much in a Noisy World. 2021-09-14 Study Suggests that COVID Hospitalizations and Deaths are up to 50% Bogus. 2021-09-14 Stanford Medicine: Garbage Studies Masquerading as Science. 2021-09-14 Glenn Greenwald: The Masking of the Servant Class: Ugly COVID Images From the Met Gala Are Now C…. 2021-09-14 Does Peer Review of Medical/Scientific Papers Mean Much Any More?. ...

Recent posts by Lloyd at MacPerformanceGuide.com, WindInMyFace.com:. 2021-09-15 What is a Vaccine? Redefining it for COVID Messaging. 2021-09-15 Science.org: A grim warning from Israel: Vaccination blunts, but does not defeat Delta - Vacci…. 2021-09-15 Israel Sees Record-High Daily Infections, Hints Fourth Vaccine Dose. 2021-09-15 COVID vaccines ===, Immune-Stimulating Prophylactic Therapeutics?. 2021-09-14 Why Mass Vaccinations Prolong & Make Epidemics Deadlier: Vaccines Expert Calls Out Governmen…. 2021-09-14 WSJ: Hearing too Much in a Noisy World. 2021-09-14 Study Suggests that COVID Hospitalizations and Deaths are up to 50% Bogus. 2021-09-14 Stanford Medicine: Garbage Studies Masquerading as Science. 2021-09-14 Glenn Greenwald: The Masking of the Servant Class: Ugly COVID Images From the Met Gala Are Now C…. 2021-09-14 Does Peer Review of Medical/Scientific Papers Mean Much Any More?. ...

We genetically prepared a new fusion gene that consists of an immune-stimulating protein, interleukin-2, and a gene of Herceptin, said Julia Y. Ljubimova, MD, PhD, professor of neurosurgery and biomedical sciences and director of the Nanomedicine Research Center. IL-2 activates a variety of immune cells but is not stable in blood plasma and does not home specifically to tumor cells. By attaching the new fusion antibody to the nanoplatform, we were able to deliver Herceptin directly to HER2-positive cancer cells, at the same time transporting IL-2 to the tumor site to stimulate the immune system. Attaching IL-2 to the platform helped stabilize the protein and allowed us to double the dosage that could be delivered to the tumor ...

Many natural products are said to boost general immunity. However, while we can scientifically study the effect of a single treatment on a single illness, at the present state of knowledge there is no way we can even know that a treatment strengthens the immune system in general. Scientists can measure the effects of an herb on individual white blood cell types and note changes in activity, but they do not know how to interpret the results of those measurements as a whole. After all, the immune system is a system, and systems are notoriously complicated to analyze. Current knowledge does not allow us to predict the ultimate effect of fine changes in the parts. To acknowledge this limitation, scientists tend to use the term immunomodulatory rather than immune-stimulating when they refer to a substance that causes measurable alterations in immune function. This terminology notes a change (modulation), but does not jump to conclusions regarding whether that change is good, bad, or ...

Weve been studying B10G5 for a while and published a paper in Clinical Cancer Research in 2015 demonstrating that using B10G5 to target sMIC can alleviate tumor-induced immune suppression and also has a huge immune-stimulating ability, explains Wu. So those results led us to think it would be a good strategy to combine B10G5 with antibodies that target immune checkpoint molecules, the off-switch of an ongoing immune response.. Finally, inspired by a case study published in 2006, the team decided to try to validate its current findings in humans. The original case reported a melanoma patient who developed anti-MIC autoantibody during anti-CTLA4 therapy and had a superior therapeutic response. So, they contacted a long-time collaborator at Oregon Health and Science University and Knights Cancer Center to obtain plasma samples collected during a clinical trial they were conducting in metastatic prostate cancer patients. Wus team looked for anti-sMIC autoantibodies in samples from ten ...

If you really want to be armed to the teeth, call and schedule our proprietary Immune Boost IV, which can be administered in less than the 30 minutes it takes to check your messages.. Youll receive one liter of a balanced electrolyte fluid with a mega-dose of WholeHealth Chicagos blend of powerful antioxidants and anti-inflammatory vitamins, including vitamin C, zinc, and B vitamins.. Its well accepted that the strength of your immune system is very much dependent on the state of your nutrition. Both vitamin C and zinc, for example, have direct immune-stimulating and antiviral effects. However, many of us are deficient in one or the other (or both) because were either inattentive to what we eat or the supplements we select arent being efficiently absorbed by our digestive tracts.. Click here and scroll down past the first box to see a list of zinc-rich foods, which youll want to regularly include in your meal plans. Along with zinc all-star the oyster, topping the charts are beef, spinach, ...

Immunology textbook for pharmacy and health professional students. Includes an overview of the immune system and chapter-by-chapter lists of medications and their properties. Discusses pathophysiologic roles for the immune system, immunotherapeutic drug targets, and immune-stimulating treatments.

Supplements I am keeping on hand for Coronavirus….. I am not going to give a long commentary about the virus, or the media coverage. But, I have been speaking with friends and family and they have asked me if I am keeping any specific items on hand in case the virus becomes widespread. I bought masks weeks ago, but I wanted to be prepared with immune-supportive measures too. Below is the complete list of what I am keeping on hand for my family in case Coronavirus becomes an issue in our house. I have been slowly collecting these items over the last month, and I am sharing them here in case it may be helpful. All of these things are widely available and not overly expensive. My collection focuses on immune-supporting rather than immune-stimulating. Some folks have already asked about this. That is why I have not included things like echinacea or elderberry.. I would not consider this in lieu of treatment by a doctor. I am merely sharing the supportive measures I personally support if we are ...

diet is often drier than pasture, or may contain fermented feeds unfamiliar to the newly weaned calves. Finally, the calves are often exhausted following weaning, being trucked, sorted and mixed with unfamiliar calves. During this time, both feed and water may be scarce. These periods of feed and water deprivation cause changes in the rumen environment and eating patterns of calves.. A main goal as a nutritionist during the first few weeks following weaning is to improve water and feed intake, said Dr. Relling. Consequently, the diet offered to calves must be both palatable and digestible in order to allow for proper animal health and performance. A natural prebiotic, such as those offered by BioZyme, can help to maintain gut balance.. According to a research study conducted by Dr. Ignacio Ipharraguerre of Christian-Albrechts University in Kiel, Germany, the apparent immune-stimulating action of BioZymes AO-Biotics may safeguard the gut against inflammation and damage resulting from ...

Aloe Vera without chemical preservatives and 99.7% Pure: Immune-Stimulating properties, stabilizes the level of Glucose, Strong Anti-inflammatory Properties

Stevens and Associates undertake market appraisals and analysis, provide strategic planning and feasibility studies. We develop business planning, marketing, communications and interpretive plans. On route, S & A help to develop and source funding packages and applications. Finally we oversee the implementation of action plans and monitor and evaluate their success.

Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute. ...

is a privately held Canadian company, founded at the end of the 19th century, specializing in the development, production, and marketing of yeasts and bacteria ...

ISCOMATRIX adjuvant-based vaccines hold promise for generating effective CTL responses against tumors (19). In this study, we investigated mechanisms of action of ISCOMATRIX adjuvant and an OVA/ISCOM vaccine. We used the ISCOM vaccine rather than the ISCOMATRIX vaccine to be sure that the Ag and adjuvant were associated, thereby enabling labeling of the Ag to track the formulation. We found that ISCOM vaccines 1) induce potent immune activation in VDLNs, 2) effectively target Ag to DCs in vivo, 3) induce DC maturation and IL-12 production in vivo, 4) facilitate Ag cross-presentation by CD8α+ DCs, and 5) mediate a cellular immune response leading to tumor protection and T cell memory induction.. Immune activation by an ISCOMATRIX vaccine has been demonstrated by lymphatic cannulation in sheep with the transient appearance of proinflammatory cytokines in efferent lymph, including IFN-γ, IL-6, IL-8, and IL-1β (27). Consistent with this report, we found high levels of bioactive IL-1β and IL-6 in ...

A nanocarrier system made up of lipid or polymeric nanoparticles can bring mRNA into cells to instruct them to make antigens and stimulate the immune system to make antibodies against SARS-CoV-2. These lipids and polymers are designed to escape enzymes that might rapidly degrade the mRNA or limit how well cells take it up. Immune-stimulating boosters can also be added to provoke a stronger immune response.. Nanomaterials could also play a key role in getting vaccines to people in resource-poor or densely populated countries. Vaccines could one day be administered through microneedle patches, single-dose slow-release implants, film-based nanomaterials, or plant viral nanoparticles for antigen delivery, which do not require cold chains. That day seems far off in the race to find a coronavirus vaccine that works, but it remains to be seen whether SARS-CoV-2 will be more like the flu, requiring a new shot every year.. Nanoformulations could potentially be used to deliver stronger doses of ...

By using MRI to detect magnetic probes of tiny iron oxide particles, an international research team for the first time has successfully tracked immune-stimulating cells implanted into cancer patients for treatment purposes. In four of the eight patients, MRI revealed that the implanted cells werent where they needed to be to be effective for treatment, says Jeff Bulte, Ph.D., an associate professor of radiology at Hopkins Institute for Cell Engineering who developed methods to optimally label cells with the clinically approved iron oxide particles. This new application of the probes -- already clinically approved for MRI scanning of the liver -- could dramatically improve efforts to test and use cellular therapies such as vaccines to treat cancer or prevent its recurrence or stem cells to repair damaged organs, say the researchers. Bulte and a team of Dutch researchers used MRI and a magnetic probe approved by both European and U.S. agencies to locate therapeutic cells injected into eight ...

Q: Dear Dr. Mao, Can ginseng effectively prevent the common cold and flu? A: Although most people in the West think of ginseng as a stimulant, in Eastern Europe ginseng is widely believed to improve overall immunity to illness. A recent study looked at the potential immune-stimulating effects of Panax ginseng when taken by mouth.

Since cancer cells depend on glucose more than normal cells, we compared the effects of low carbohydrate (CHO) diets to a Western diet on the growth rate of tumors in mice. To avoid caloric restriction-induced effects, we designed the low CHO diets isocaloric with the Western diet by increasing protein rather than fat levels because of the reported tumor-promoting effects of high fat and the immune-stimulating effects of high protein. We found that both murine and human carcinomas grew slower in mice on diets containing low amylose CHO and high protein compared with a Western diet characterized by relatively high CHO and low protein. There was no weight difference between the tumor-bearing mice on the low CHO or Western diets.. Additionally, the low CHO-fed mice exhibited lower blood glucose, insulin, and lactate levels. Additive antitumor effects with the low CHO diets were observed with the mTOR inhibitor CCI-779 and especially with the COX-2 inhibitor Celebrex, a potent anti-inflammatory ...

Essential oils are the subtle, cola tile liquids that are distilled from plants, shrubs, flowers, trees, bushes and seeds through an ancient and delicate process. Science is re-discovering the incredible healing power of essential oils and beginning to acknowledge their value. Essential oils are known to be immune-stimulating, anti-viral, anti-fungal, anti-septic, anti-microbial, anti-fungal and anti-parasitic. Many essential oils contain healing qualities and can be used to aid healing of cuts, wounds, burns, bacterial and fungal infections through topical application or inhalation ...

The main point to take away from this weeks Phytonutrient Friday post is that Aloe Vera is or at least should be, an indispensable part of all of our herbal dispensaries. The aloe plant has important medicinal uses making it one of the most respected medicinal plants found on the planet. Modern researchers have identified several reasons why aloe gel spurs wound healing: It has antibacterial, antifungal and antiviral compounds that help prevent wound infections. It also has immune-stimulating and anti-inflammatory compounds, and it stimulates collagen synthesis and skin regeneration after a burn. Aloe gel contains vitamins C and E, plus the mineral zinc. Aloe Vera gel is soothing, anti-inflammatory, and antibacterial - it helps heal acne, improve the appearance of wrinkles, and hydrates damaged skin. Applying a thin layer of this amazing gel will help ease discomfort caused by painful skin irritations, and acne ...

Previous in vitro and in vivo studies and clinical results with immune-deficiency syndrome patients treated with Ukrain, a semisynthetic drug from alkaloids of Chelidonium majus L. and thiophosphoric acid (1) showed immune-stimulating and immune-modulating properties in various test systems. The experiments described here were designed to examine the possibilities of influence of the biocatalyst Ukrain in vitro system environments on certain cell-systems, such as effector-target.. ...

Echinacea attracts butterflies, moths, bees, and other insects into the garden with its captivating blooms. The roots, leaves, seeds, and flowers are all medicinal; and can be made into a immune-stimulating tea…. ...

Nature has bestowed us with a large variety of healthy berries which are also known as super foods for their several benefits and advantages. One of these berry varieties is called Acai Berry. Acai berries are one of the healthiest berries in the world and are found in the forests of Amazon.. These berries are known for their healing properties, immune-stimulating qualities and many other health benefits. Acai berries are also available in their supplement form, because of its many useful qualities. The following are some of the most effective health benefits of taking acai berry supplements:. ...

Recent research has shown that milk proteins can yield bioactive peptides with opioid, mineral binding, cytomodulatory, antihypertensive, immunostimulating, antimicrobial and antioxidative activity in the human body.

TY - JOUR. T1 - Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. AU - Hase, Koji. AU - Basnet, Purusotam. AU - Kadota, Shigetoshi. AU - Namba, Tsuneo. PY - 1997/7/22. Y1 - 1997/7/22. N2 - Celosian, an acidic polysaccharide from the seeds of Celosia argentea (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-α (TNF-α) production in mice. Celosian also induced the production of interleukin-1β (IL-1β) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000/μg/ml). Moreover, celosian induced IL-1β secretion in human mononuclear cells. In addition, celosian enhanced gamma interferon (IFN-υ) production activity of concanavalin A (Con A) in mice spleen cells, though ...

Treatment with the immune-stimulating agent, Keytruda® (pembrolizumab), provides impressive long-term outcomes for some patients with metastatic or recurrent head and neck cancer. These results were recently presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO).. Globally, head and neck cancer comprises the seventh most common type of cancer with an estimated 400,000-600,000 diagnoses every year. Head and neck squamous cell cancer (HNSCC) refers to head and neck cancer that originates in certain cells called squamous cells.. Metastatic or stage IV head and neck cancer refers to cancer that has spread from its site of origin to distant sites in the body. Overall survival at 5 years for patients diagnosed with metastatic head and neck cancer has remained at less than 4%, indicating a significant need in improved treatment for patients with this disease. Recurrent head and neck cancer refers to cancer that has recurred or progressed despite prior ...

Kafkas Univ Vet Fak Derg 17 (2): 239-242, 2011 DOI:10.9775/kvfd.2010.3122 . RESEARCH ARTICLE. Summary. An. in vitro. cultivation method for spleen and head kidney ...

Ozonotherapy is a modern medical procedure of ozone application in medical- prophylactic purposes.. Dynamically developing last 10 years, ozonotherapy is a priority direction of scientific researches of many centres and is considered as medicine of the ХХ1st century. Gained experience allows to make conclusion, that ozonotherapy is characterized with easiness in application, good acceptability in patients, practically complete absence of ghost effects and high medical-social and economic efficiency.. Ozonotherapy has a wide range of action, bactericidal, vitusocidal, fungicidal, immunostimulating, antihypoxical, detoxical influence. Use of medical ozone reduces treatment time, lethality and invalidisation degree.. Systematic applied ozone recovers oxygen transport, liberates oxygen, normalizes metabolism, hormonal background, removes acts as vasohypotonic preparation , improves microcirculation and fluidity of blood. All this gives opportunity to apply ozone in therapy, neurology, gynecology, ...

Immune protection of the body cavities depends on the swift activation of innate and adaptive immune responses in nonclassical secondary lymphoid organs known as fat-associated lymphoid clusters (FALCs). Compared with classical secondary lymphoid organs such as lymph nodes and Peyers patches, FALCs develop along distinct differentiation trajectories and display a reduced structural complexity. Although it is well established that fibroblastic reticular cells (FRCs) are an integral component of the immune-stimulating infrastructure of classical secondary lymphoid organs, the role of FRCs in FALC-dependent peritoneal immunity remains unclear. Using FRC-specific gene targeting, we found that FRCs play an essential role in FALC-driven immune responses. Specifically, we report that initiation of peritoneal immunity was governed through FRC activation in a myeloid differentiation primary response 88 (MYD88)-dependent manner. FRC-specific ablation of MYD88 blocked recruitment of inflammatory monocytes ...

Oncolytic viruses have gained much attention in recent years, due, not only to their ability to selectively replicate in and lyse tumor cells, but to their potential to stimulate antitumor immune responses directed against the tumor. Vesicular stomatitis virus (VSV), a negative-strand RNA virus, is under intense development as an oncolytic virus due to a variety of favorable properties, including its rapid replication kinetics, inherent tumor specificity, and its potential to elicit a broad range of immunomodulatory responses to break immune tolerance in the tumor microenvironment. Based on this powerful platform, a multitude of strategies have been applied to further improve the immune-stimulating potential of VSV and synergize these responses with the direct oncolytic effect. These strategies include: 1. modification of endogenous virus genes to stimulate interferon induction; 2. virus-mediated expression of cytokines or immune-stimulatory molecules to enhance anti-tumor immune responses; 3.

A vaccine against C. trachomatis infection has proven difficult to develop. Early vaccine studies showed that whole inactivated bacterial cells administered intramuscularly were partially protective in human and primate trials. Primate vaccine trials and human experimental infection studies suggested that C. trachomatis immunity was in part strain specific, and the identification of MOMP as the strain-specific antigen of C. trachomatis quickly focused vaccine efforts on this protein. In general, use of MOMP or peptide epitopes derived from it as a vaccine has engendered variable or no protective immunity in a variety of animal model systems. The best results were observed when MOMP was used as a structurally intact molecule, suggesting that conformationally intact antigenic sites on the molecule are important for protective immunity.. We previously reported that MOMP DNA administered parenterally was also partially effective in inducing protective immunity against lung infection with MoPn. The ...

ASHFORD BUS 375 Week 2 DQ 1 Needs Assessment http://l4k.hwork.biz/courses/ashford-bus-694-week-2-predicting-exchange-rates-42896.html - ASHFORD BUS 694 Week 2 Predicting Exchange Rates ISCOM 383 Week 1 Individual Assignment Value Chain and Supply Chain Article Analysis Paper CIS336 Entire Course: Devry University: http://t1g.hwork.biz/courses/ashford-eco-203-week-1-dq-2-role-of-government-92644.html - ASHFORD ECO 203 Week 1 DQ 2 Role of Government SCI 100 Week 3 Individual Assignment Nutrition and Fitness PSY 320 COMPLETE COURSE (Human Motivation) http://m4e.hwork.biz/courses/soc-313-week-1-dq-psychosocial-issues-in-huntingtons-disease-97365.html - SOC 313 Week 1 DQ Psychosocial Issues in Huntington’s Disease ASHFORD EDU 623 Week 4 Philosophy of Education COM 200 Week 4 Interpersonal Conflict in Film http://ng5.hwork.biz/courses/ashford-com-321-week-3-dq-1-not-communicating-71665.html - ASHFORD COM 321 Week 3 DQ 1 Not Communicating OI 361 Week 2 Learning Team Assignment Benefits and ...

In addition to its anti-microbial and immune-stimulating properties, both magnesium as well as chloride have other important functions in keeping us young and healthy. Chloride, of course, is required to produce a large quantity of gastric acid each day and is also needed to stimulate starch-digesting enzymes. Magnesium is the mineral of rejuvenation, and prevents the calcification of our organs and tissues that is characteristic of the old-age related degeneration of our body.. Using other forms of magnesium is less advantageous, because these have to be converted into chlorides in the body anyway. If we take magnesium as oxide or carbonate, we then need to produce additional hydrochloric acid to absorb the magnesium. Many ageing individuals, especially those with chronic diseases who desperately need more magnesium, cannot produce sufficient hydrochloric acid, and then cannot absorb the oxide or carbonate.. Epsom salt is magnesium sulphate. It is soluble but not well-absorbed, and acts mainly ...

An induction of long-term cellular and humoral immunity is for the goal of vaccines, but the combination of antigens and adjuvant remain unclear. Here, we show, using a cellular vaccine carrying foreign protein antigen plus iNKT cell glycolipid antigen, designated as artificial adjuvant vector cells (aAVCs), that mature XCR1(-) DCs in situ elicit not only ordinal antigen-specific CD4(+)T cells, but also CD4(+) Tfh and germinal center, resulted in inducing long-term antibody production. As a mechanism for leading the long-term antibody production by aAVC, memory CD4(+) Tfh cells but not iNKTfh cells played an important role in a Bcl6 dependent manner. To develop it for influenza infection, we established influenza hemagglutinin-carrying aAVC (aAVC-HA) and found that all the mice vaccinated with aAVC-HA were protected from life-threatening influenza infection. Thus, the in vivo DC targeting therapy by aAVC would be useful for protection against viral infection.. ...

HIV-sites Julian Lieb, M.D STIMULATING IMMUNE FUNCTION TO DEFEAT THE HUMAN IMMUNODEFICIENCY VIRUS, RESISTANT BACTERIA, THE TUBERCULOSIS MICROORGANISM, AND OTHER PATHOGENS: A SUPPRESSED INNOVATION Stimulating defective immune function to perform efficiently is a desirable approach to defeating pathogens. Such stimulation is represented as unavailable, while in truth the immunostimulating properties of lithium and antidepressants were documented many years ago.1-4 A therapeutic claim is reinforced when the mechanism is known. Prostaglandins, when produced excessively, depress every component of immune function, and induce microbial replication. Wherever HIV comes into contact with arachidonic acid, an envelope glycoprotein powerfully converts this precursor to prostaglandin E2, depressing immune function and promoting viral replication, excessive prostaglandin E2 a leading candidate for the immunosuppression that is the hallmark of AIDS.5-7 Antidepressants inhibit the synthesis of prostaglandin ...

The authors analyze the literature publications and the results of their original investigations concerning the application of the propolis-based pharmacological products for the treatment of acute and chronic diseases of the upper respiratory tract and ears. The desirability of the more extensive application of the propolis-containing medicines in the routine otorhinolaryngological practice is emphasized bearing in mind their numerous biological effects including antibiotic, anti-inflammatory, immunostimulating, anti-oxidative, anesthetic, and cytostatic actions ...