TY - JOUR. T1 - Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. AU - Tian, Aiguo. AU - Shi, Qing. AU - Jiang, Alice. AU - Li, Shuangxi. AU - Wang, Bing. AU - Jiang, Jin. N1 - Publisher Copyright: © 2015 Tian et al.. PY - 2015. Y1 - 2015. N2 - Many adult tissues are maintained by resident stem cells that elevate their proliferation in response to injury. The regulatory mechanisms underlying regenerative proliferation are still poorly understood. Here we show that injury induces Hedgehog (Hh) signaling in enteroblasts (EBs) to promote intestinal stem cell (ISC) proliferation in Drosophila melanogaster adult midgut. Elevated Hh signaling by patched (ptc) mutations drove ISC proliferation noncell autonomously. Inhibition of Hh signaling in the ISC lineage compromised injury-induced ISC proliferation but had little if any effect on homeostatic proliferation. Hh signaling acted in EBs to regulate the production of Upd2, which activated the ...
In this chapter we review the literature with respect to what is known about how Escherichia coli colonizesthe mammalian intestine. We begin with a brief discussion of the mammalian large intestine, the major site that commensal strains of E. coli colonize. Next, evidence is discussed showing that, in order to colonize, E. coli must be able to penetrate and grow in the mucus layer of the large intestine. This is followed by discussions of colonization resistance, i.e., factors that are involved in the ability of a complete microbiota (microflora) to resist colonization by an invading bacterium, the advantages and disadvantages of the in vivo colonization models used in colonization research, the initiation and maintenance stages of E. coli colonization, and the rate of E. coli growth in the intestine. The next two sections of the chapter discuss the role of motility in colonization and how adhesion to mucosal receptors aids or inhibits penetration of the intestinal mucus layer and thereby either
To determine whether genes involved in mitochondrial dynamics (fission, fusion, movement, and turnover) play a role in ISC function, we used the ISC/EB-specific, RU486-inducible 5961-Gal4GeneSwitch (5961GS) driver to direct expression of UAS-RNAi lines in ISCs/EBs in the adult midgut (see Materials and methods for specific RNAi lines tested). Use of the drug-inducible system permits comparison of genetically identical individuals that are either expressing (+RU486) or not expressing (EtOH/−RU486) the transgene of interest. Overexpression of srl led to a decrease in intestinal dysplasia, as previously reported (Rera et al., 2011). However, in contrast to our expectations, RNAi-mediated depletion of Pink1 or Parkin resulted in a drastic improvement in intestinal homeostasis in aged flies. Manipulation of other factors tested had no significant effect on ISC maintenance or tissue homeostasis during the time points assayed (10, 30, and 50 d post-eclosion).. Mutations in the ...
TY - JOUR. T1 - Phosphorylation of pp62 and pp54 src-like proteins in a rat intestinal cell line in response to gastrin. AU - Singh, Pomila. AU - Narayan, S.. AU - Adiga, R. B.. PY - 1994. Y1 - 1994. UR - http://www.scopus.com/inward/record.url?scp=0028121604&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028121604&partnerID=8YFLogxK. M3 - Article. C2 - 8074224. AN - SCOPUS:0028121604. VL - 267. JO - American Journal of Physiology - Endocrinology and Metabolism. JF - American Journal of Physiology - Endocrinology and Metabolism. SN - 0193-1849. IS - 2 part 1. ER - ...
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.. Please dont hesitate to contact the Editorial Office if you have any questions or concerns.. ...
Gender is one of the factors influencing the intestinal microbial composition in mammals, but whether fish also have gender-specific intestinal microbial patterns remains unknown. In this decade, endocrine disrupting chemicals in surface and ground water of many areas and increasing observation of freshwater male fish displaying female sexual characteristics have been reported. Here we identified the difference in intestinal microbiota between male and female zebrafish, and revealed the influence of endocrine disrupting chemicals on zebrafish intestinal microbiota by using high-throughput sequencing. The results indicated that Fusobacteria, Bacteroidetes and Proteobacteria were dominant in the gut of zebrafish and there were no obvious gender-specific intestinal microbial patterns. Two endocrine disrupting chemicals, Estradiol (E2) and Bisphenol A (BPA), were selected to treat male zebrafish for 5 weeks. E2 and BPA increased vitellogenin expression in the liver of male zebrafish and altered the
Interesting traits could be components of the innate immune systems associated with high/low immunologic responders which may be measured in blood/milk, but also specific metabolic indicator traits of microbiota . Furthermore Natural Antibodies (Nab) could potentially be defined as a parameter of humoral innate immunity at the effector level. A prerequisite for these indicator traits to qualify as a selection tool / marker is that they are heritable, quantifiable, stable at specific time points and locations and linked to genetic variation in disease resistance.. The objective of the programme Intestinal health and Disease resistance in cattle, pig and poultry is to develop and to validate tools/phenotypes/technologies for genetic improvement in robustness of animals. This will contribute to improvement of health and welfare of animals, reduction in losses due to environmental challenges, improvement of longevity and reduction in use of antibiotics/drugs.. ...
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TY - JOUR. T1 - Developmental ecology of the neonatal intestine. T2 - Introduction. AU - Gaskins, H Rex. AU - Lien, E. L.. PY - 1999/5/11. Y1 - 1999/5/11. UR - http://www.scopus.com/inward/record.url?scp=0032965108&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032965108&partnerID=8YFLogxK. M3 - Editorial. AN - SCOPUS:0032965108. VL - 69. JO - American Journal of Clinical Nutrition. JF - American Journal of Clinical Nutrition. SN - 0002-9165. IS - 5. ER - ...
MilPro-TX®, a feed additive, supports intestinal health in animals by reinforcing the intestinal mucosa barrier and assisting in the regeneration of epithelium.
Salmonella continues to be an important cause of disease. Every now and then it emerges from its slumbering state and makes newspaper headlines when food has been contaminated and vulnerable groups become ill. Apart from strict hygiene measures, feeding strategies can also contribute to diminishing salmonella incidents. Part 1 of this two part series discusses technical means influencing salmonella proliferation and intestinal health in pigs.
Breaking the Vicious Cycle: Intestinal Health Through Diet | Elaine Gottschall | ISBN: 8601200453447 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.
When two people both eat a similar diet but one gets heart disease and the other doesnt, we currently think the cardiac disease develops because of their genetic differences; but our studies show that is only a part of the equation, said Stanley Hazen, M.D., Ph.D., Staff in Lerner Research Institutes Department of Cell Biology and the Heart and Vascular Institutes Department of Cardiovascular Medicine and Section Head of Preventive Cardiology & Rehabilitation at Cleveland Clinic, and senior author of the study. Actually, differences in gut flora metabolism of the diet from one person to another appear to have a big effect on whether one develops heart disease. Gut flora is a filter for our largest environmental exposure -- what we eat. ...
In this study, we have revealed novel and important aspects of the role of Nod2 for the development and composition of the mammalian intestinal microbiota. A detailed view into the colonisation process during mouse development highlights that microbial composition is not only influenced by genotype, but also by stage of development. Previous studies based on fingerprinting approaches found that the caecal microbiota in SPF mice changes drastically with age, but stabilises after 4 weeks.45 In our study based on 16S rRNA gene clone libraries, the microbial community continued to change after week 4b, fluctuating in the proportions of the three most abundant phyla (Firmicutes, Bacteroidetes and Proteobacteria; figure 1B) until 10 weeks of age, at which point stable Firmicutes-dominated communities became apparent. Earlier culture-based studies found that the caecal microbiota matures as early as 4-5 weeks of age. These differences likely highlight the limitations of culture-dependent methods.46 Our ...
The intestinal epithelium acts as a physical barrier that separates the intestinal microbiota from the host and is critical for preserving intestinal homeostasis. The barrier is formed by tightly linked intestinal epithelial cells (IECs) (i.e. enterocytes, goblet cells, neuroendocrine cells, tuft cells, Paneth cells, and M cells), which constantly self-renew and shed. IECs also communicate with microbiota, coordinate innate and adaptive effector cell functions. In this review, we summarize the signaling pathways contributing to intestinal cell fates and homeostasis functions. We focus especially on intestinal stem cell proliferation, cell junction formation, remodelling, hypoxia, the impact of intestinal microbiota, the immune system, inflammation, and metabolism. Recognizing the critical role of KRAS mutants in colorectal cancer, we highlight the connections of KRAS signaling pathways in coordinating these functions. Furthermore, we review the impact of KRAS colorectal cancer mutants on pathway
Epithelial cells lining the intestinal tract function as a selective barrier that regulates nutrient uptake. In addition, the epithelial barrier protects underlying tissue compartments from pathogens and toxins in the lumen of the intestine. The intestinal epithelium is highly dynamic and actively turned over. Regulated intestinal stem cell proliferation and differentiation are required for normal intestinal homeostasis and repair after injury. Many gastrointestinal diseases including IBD are characterized by unbalanced proliferation and differentiation of intestinal epithelial cells. In fact, accumulating evidence implicates the maintenance of intestinal homeostasis as a fundamental regulator of intestinal protein expression and epithelial barrier regulation. Patients with IBD clinically present with relapsing diarrhea that has been attributed in part to aberrant epithelial barrier function, the epithelial leaks appear early due to micro-erosions resulting from upregulated epithelial apoptosis ...
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This is a randomized, double-blind, placebo controlled crossover design with two 3-week interventions and a 5-week washout period in between. Thirty-six participants will be enrolled. With informed consent, the daily questionnaire will be administered and a baseline stool sample will be obtained during the week before the start of each intervention period. Blood and saliva will be collected on the first and last day of each intervention period to assess immune function. A final stool sample will be obtained in the last week of the intervention period. Nutritional status, which can impact immune function, will be assessed using the Mini-Nutritional Assessment, Block Fiber Screen, and the Block 2005 Food Frequency Questionnaire. Daily questionnaires will record intake of the probiotic or placebo, level of stress, hours of sleep, visits to the physician, new medications, number of stools, etc. The Gastrointestinal Symptom Response Scale, which records gastrointestinal symptoms, such as bloating, ...
Probzyme is a comprehensive, chewable vegetarian formulation designed to support digestive tract health and nutrient absorption in people of all ages.
A high-potency probiotic, Life 5™ represents the culmination of years of extensive research. Life 5 builds and restores core intestinal health by providing five clinically proven probiotic strains including two advanced super strains to enhance intestinal health, sustain energy and improve immunity. Life 5 contains 10 billion active cultures and improves colonization up to 10 times ...
Probiotics that help support intestinal health for womenSupports digestive and vaginal healthSpecifically formulated to support the intestinal health of womenGluten-Free + Non-GMO Strains + Made in Canada + Shelf-stableDescriptionConsidering 80% of our immunity comes from our gut, and women tend to require an even high
The development of the intestine and early establishment of commensal bacteria is important for rapid growth and enteric disease resistance of the modern broiler. Three studies measured the impact of yeast derivatives in diets of broilers. The objective of the first study was to determine if yeast products alone or in combination effected performance or gut morphology of broilers during a mild coccidia challenge. Day-old Cobb 500 chicks were placed in floor pens on litter seeded with coccidia and fed diets with or without yeast products. The objectives of the second and third studies were to 1) evaluate the effect of feeding cecal droppings collected from heavy (HW) or low weight (LW) broilers on performance and 2) to determine if dietary supplementation with yeast derivatives would effect growth and gut morphology in broilers fed the cecal droppings from HW or LW populations. Cobb 500 chicks were divided into two groups (HW or LW microflora; n=1400/group) and given access to the cecal droppings ...
As often happens in our Wheat Belly conversations, we end up talking about bowel health. After all, our unwitting bowels are the primary means through which we (used to) ingest this thing that annoys, erodes, irritates, and generally wreaks havoc on our health. The gastrointestinal tract, probably more than any other organ system, is the unhappy recipient of most of wheats destructive properties. The composition of your bowel flora, the little bacterial critters populating your gastrointestinal tract and outnumbering the number of cells in the rest of your body (yes: you are mostly a bacterial organism, judging by numbers! over 2 pounds in total), are increasingly appearing to be major players in overall health. Witness, for instance, this talk of fecal transplants in which the bowel flora/stool of a slender animal is transplanted into the intestinal tract of an overweight animal-and the overweight animal loses weight. Fecal bacteriotherapy may, in fact, be entering mainstream treatment for ...
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Be particularly wary of any food that you crave or eat large quantities of. That is an indication of a possible problem with that food. The usual allergens are wheat, corn, eggs, chocolate, and/or milk products.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Product results may vary from person to person. † Compare price is the price compared to the manufacturers suggested retail price or estimated selling price of the same or similar item at full-price stores. See Pricing Policy for details.. Information provided on this site is solely for informational purposes only. It is not a substitute for professional medical advice. Read more ©2000-2020 Nutrition Express. All rights reserved ...
Several studies have shown that gut bacteria have a role in diabetes in murine models. Specific bacteria have been correlated with the onset of diabetes in a rat model. However, it is unknown whether human intestinal microbes have a role in the development of autoimmunity that often leads to type 1 …
TY - JOUR. T1 - Deconvoluting the intestine. T2 - Molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. AU - Li, Xing. AU - Madison, Blair B.. AU - Zacharias, William. AU - Kolterud, Åsa. AU - States, David. AU - Gumucio, Deborah L.. PY - 2007/6/27. Y1 - 2007/6/27. N2 - Reciprocal cross talk between the endodermally derived epithelium and the underlying mesenchyme is required for regional patterning and proper differentiation of the developing mammalian intestine. Though both epithelium and mesenchyme participate in patterning, the mesenchyme is thought to play a prominent role in the determination of the epithelial phenotype during development and in adult life. However, the molecular basis for this instructional dominance is unclear. In fact, surprisingly little is known about the cellular origins of many of the critical signaling molecules and the gene transcriptional events that they impact. Here, we profile genes that are expressed in the separate ...
The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes
Human bodies are highly fluctuating complex systems. They detect and integrate the clues from changing environments and their own internal states, making numerous responses after delicate computation and regulation. Traditional routes of drug administration includes oral intake or intravenous injection may be too simplified to promptly fit the real-time condition of the body states. In addition, the frequent and repetitive intake of drugs may be annoying, and sometimes the invasive processes are suffering, bringing inconvenience to our daily lives. Medical instruments or electrical monitors can instantaneously detect and response to some specific physiological or pathological parameters, but they are usually too heavy and bulky to carry, which restrict the mobility of patients while using it. Therefore we aim to program the intestinal microbes to build our novel smart drug delivery systems-PEPDEX. There are around \(10^{13}\) to \(10^{14}\) microorganisms inhabiting in our gastrointestinal ...
Human bodies are highly fluctuating complex systems. They detect and integrate the clues from changing environments and their own internal states, making numerous responses after delicate computation and regulation. Traditional routes of drug administration includes oral intake or intravenous injection may be too simplified to promptly fit the real-time condition of the body states. In addition, the frequent and repetitive intake of drugs may be annoying, and sometimes the invasive processes are suffering, bringing inconvenience to our daily lives. Medical instruments or electrical monitors can instantaneously detect and response to some specific physiological or pathological parameters, but they are usually too heavy and bulky to carry, which restrict the mobility of patients while using it. Therefore we aim to program the intestinal microbes to build our novel smart drug delivery systems-PEPDEX. There are around \(10^{13}\) to \(10^{14}\) microorganisms inhabiting in our gastrointestinal ...
Modeling physiological and pathophysiological processes in the human intestinal tract outside the human body has been a daunting challenge for…
Local immune system of intestine helps controlling microbes in the intestine. However, when bile flow is obstructed, this immune system become overly active and can cause autoimmune disease. Edited...
Research in the departments 14 laboratories is primarily focused on diseases of developing countries. Laboratory-based research may be supplemented by field-based studies of epidemiological and ecological aspects of infectious disease transmission and control.. Infectious and immune-mediated diseases currently under study include HIV/AIDS, Tuberculosis, Chagas, Malaria, Pneumonia, Enteric Diseases, Inflammatory Bowel, and Autoimmune diseases. Further immunologic studies focus on genetic regulation of the immune response, the interplay between the innate immune system and intestinal microbial communities, the function and regulation of T-cell-derived cytokines and cytokines involved in the regulation of inflammation.. Research in the department emphasizes basic pathogenic mechanisms that may lead to better diagnostic tools, the development of vaccines and other interventions for prevention and control of infection and disease, and the identification of new targets for antiviral and antiparasitic ...
The gut of experimental animals was differentially processed for histological examination depending on whether suspensions of MNCs from the intestinal epithelium and lamina propria were also prepared for flow cytometry analysis. Prior to the preparation of suspensions of gut-derived MNCs, 3 proximal, median, and distal fragments (5-10 mm long) of both small and large bowel were collected for histological examination. For the other experimental animals, the entire length of small and large bowel from SCID recipients was wrapped to form a roll before fixation in 10% neutral buffered formaldehyde for 24 h. Specimens were then embedded in paraffin and three 6-μm sections were taken 250 μm apart through the entire thickness of the bowel loops. Each section was stained with hematoxylin and eosin. Each section was examined and scored in a blind fashion by one of us (D. Banerjee) as described (17). Briefly, grade 0 corresponded to the absence of histological abnormalities; grade 1 to the presence of ...
Health and beauty are forged in the stomach and intestines.✅ Intestinal health reflects how we feel, we are and behave. Thats why we have to take into ac...
Causes for concern are both an overgrowth of microorganisms that are normally present in the intestines and the presence of microorganisms that are not normally present in the intestines. Either condition signals that major physiological pathways in the intestinal environment are outside homeostatic limits. Some of the immediate consequences can include adverse alterations in pH, digestion, and absorption. These factors set the stage for further deviations from health, including the retention and proliferation of microorganisms that would be maintained ordinarily at a lower concentration, or would be rapidly expelled. Such conditions can produce anatomic disruption of the intestinal mucosa resulting from the physical infestation of the microorganism, and chemical insult and physiological upset of the mucosa caused by adverse reactions to the metabolic products of the invader. Maldigestion and malabsorption of nutrients can produce longer-term dysfunction of the host. This condition can persist ...
BioAssay record AID 236268 submitted by ChEMBL: Fraction absorbed in human intestine after oral administration compound was measured.
Leaky gut conditions were simulated using 3D models of human intestines to identify biomarkers for diagnostics and therapeutic development in a recent study.
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The original probiotic offered by GHT in a lemon-power base, replenishes beneficial microflora in the intestines to help sustain and promote intestinal health.
This Short Course is suitable for anyone wanting to learn easy and practical tips to improve digestive and, consequently, mood health. Whether you have a gut-related condition, low mood or just wish to make positive choices to your intestinal health, this course is for you.. What you will learn. You will learn about the importance of the digestive system and how significant gut health is for your mood. You will cover issues surrounding diet, stress, lifestyle and weight control in relation to a healthy gut.. You will explore the physiology of the gut and what happens every time you put food in your mouth. You will discover the effect your choices have on healthy gut bacteria, and how different parts of the body are involved in and/or affected by digestion.. Most importantly, this course will equip you with the tools to improve your own digestion holistically through diet and lifestyle.. ...
The existence of important infection-causing ExPEC lineages (i.e., genetically closely related E. coli clones or clonal groups) has been recognized for the past 40 years. However, identification and detailed characterization of specific lineages has only recently been advanced, owing to the development of new methods for bacterial genotyping. Since ExPEC can colonize and persist in the human intestinal tract without detriment to the host, the operational definition of ExPEC is critical for defining the chain of ExPEC transmission from non-human reservoir to human intestinal colonization to active infection.
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.. Please dont hesitate to contact the Editorial Office if you have any questions or concerns.. ...
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Applications for Health Improvement Supports glutamine replenishment during and after metabolic stress Supports intestinal health and barrier integrity Supports healthy immune function Supports muscle mass retention Supports increased glutathione synthesis Helps repair the intestinal lining of the gut 85 Servings
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