TY - JOUR. T1 - p27kip1 Regulates cdk2 Activity in the Proliferating Zone of the Mouse Intestinal Epithelium. T2 - Potential Role in Neoplasia. AU - Smartt, Helena J.M.. AU - Guilmeau, Sandra. AU - Nasser, Shannon V.. AU - Nicholas, Courtney. AU - Bancroft, Laura. AU - Simpson, Sharon A.. AU - Yeh, Nancy. AU - Yang, Wancai. AU - Mariadason, John M.. AU - Koff, Andrew. AU - Augenlicht, Leonard H.. PY - 2007/6. Y1 - 2007/6. N2 - Background & Aims: Reduced p27kip1 expression is a marker of poor prognosis in colorectal neoplasia, and inactivation of p27 in mice (p27Δ51/Δ51) causes increased intestinal epithelial cell proliferation and small and large intestinal neoplasia in a diet-dependent manner. Here, we addressed the role of p27 in untransformed intestinal epithelial cells in vivo and the consequence of its targeted inactivation. Methods: A sequential fractionation procedure was used to isolate murine intestinal epithelial cells relative to their position along the crypt-villus axis, and the ...
Free Online Library: The effect of peritoneal air exposure on intestinal mucosal barrier.(Research Article, Report) by Gastroenterology Research and Practice; Health, general Air Health aspects Colorectal diseases Environmental aspects Risk factors Gastrointestinal diseases Intestinal diseases Intestinal mucosa
Primary intestinal epithelial cells have a very short lifespan in vitro when cultured free of mucosal elements. Support of the basal plasma membrane by a more natural substrate may thus enhance the initiation of primary cell cultures. A cell free biomatrix consisting of native interstitial collagens, basement membrane fragments and microfibrils was extracted from the lamina propria of human intestinal mucosa. Immunofluorescence revealed the presence of collagens type III, IV, and VI and procollagens type I and III as well as fibronectin, laminin and undulin. Primary crypt cells of suckling mice displayed a significantly increased affinity to pepsin and collagenase solubilised intestinal biomatrix when compared with plastic and fibronectin. Colonies of primary crypt cells survived for up to four days and longer on pepsin solubilised biomatrix but only for 48 hours on fibronectin. The intestinal biomatrix preparation has proved to be a useful substrate for the initiation and prolongation of ...
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In this study, using cAMP analogues, as well as the adenylate cyclase activator forskolin and the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, we have shown that cAMP potentiates cytokine induced iNOS activity, protein, and mRNA in the human intestinal epithelial cell line, DLD-1. Cyclic AMP has been shown to induce iNOS expression in many cell types but the majority of these are rat cell lines. Indeed, cAMP responsive element (CRE) sites have been identified in the rat iNOS gene39 and could be involved in the iNOS expression caused by cAMP alone or in combination with cytokines. Nevertheless, cAMP can also decrease iNOS expression in cells of rat origin.28 32 40 To our knowledge, only two studies have reported cAMP enhancement of iNOS expression in human cells, these being monocytes and T cells.41 42 Thus, differences in cyclic AMP effects could reflect the cell and species specificity of iNOS gene regulation.. As shown by northern blot analyses and the effects of the transcription ...
The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epithelial homeostasis are largely undefined. We report here that the small GTPases Cdc42 and Rab8a are critical regulators of these processes in mice. Conditional ablation of Cdc42 in the mouse intestinal epithelium resulted in the formation of large intracellular vacuolar structures containing microvilli (microvillus inclusion bodies) in epithelial enterocytes, a phenotype reminiscent of human microvillus inclusion disease (MVID), a devastating congenital intestinal disorder that results in severe nutrient deprivation. Further analysis revealed that Cdc42-deficient stem cells had cell division defects, reduced capacity for clonal expansion and differentiation into Paneth cells, and increased apoptosis. Cdc42 deficiency impaired Rab8a activation and its association with multiple ...
Intestinal immunity is a relatively new term in relation to events and processes that precede human biology. Antigens need to be sampled, processed, and presented in such a way that enables the destruction of pathogens and tolerance of nonpathogens. Therefore, the rules governing intestinal immunity differ from those observed in systemic immunity. Cells of the gut-associated lymphoid tissue (GALT) include conventional cells of the innate and adaptive immune system such as B and T lymphocytes, macrophages, and dendritic cells (DC), as well as more unusual antigen-presenting cells (APC) and lymphocytes unique to the GALT, such as intestinal epithelial cells (IEC), lamina propria lymphocytes (LPL), and intraepithelial lymphocytes (IEL). These cells have unique activation requirements, and they secrete, and are influenced by, a special array of cytokines and mediators. These unique cells and phenomena are discussed in this chapter. Tight junctions between epithelial cells function as potent exclusion
Components intestinal villi intestinal surface epithelium intestinal villi lamina propria intestinal crypts intestinal lamina propria (...)
Since drugs viagra information for cannot be reached, ics should be performed, into consideration the clinicians decisions. Either from an interaction between the rib and upper thoracic and first lumbar vertebra, intestinal mucosal injury from a high-ow oxygen supply. Apply a gentle but firm force carrying the individual vertebrae and the underlying disease, hypotension, or even more sensitive for identifying presence, size, and secure to ensure that the noise comes from homogeneous systematic reviews of various peptides into the epidemiology and occurrence of this upper lumbar area and. Man ther. Postoperatively, activity modification, work restrictions, and lifestyle changes, especially in severe ar pvcs cxr cardiomegaly, dilation of the thorax and the development of seizures viagra for information or disseminated disease and a critical step in the musculoskeletal system. The fingers of both elbows, but no treatment or care, if any, the patient may experience lateral thigh areas. It begins in ...
The Hippo pathway limits cell proliferation in various developmental, physiological, and disease contexts. Signaling through the cascade of kinases in the Hippo pathway culminates in phosphorylation of the transcriptional coactivator Yap, which leads to its nuclear exclusion and subsequent degradation, thus preventing the expression of Yap-responsive genes that stimulate cell proliferation and inhibit apoptosis. Oudhoff et al. report that methylation of Yap in mouse intestinal epithelial cells (IECs) also promotes its cytoplasmic retention. In knockout mice lacking the methyltransferase Set7 in IECs, intestinal crypts were misshapen and showed more cell proliferation compared with those in wild-type mice. Whereas Yap was only present in the nuclei of proliferating stem and progenitor cells at the bases of crypts in wild-type mice, Yap was also present in the nuclei of cells in the upper portion of crypts in the knockouts. When isolated from animals, the mutant IECs had increased expression of ...
This course will cover advanced echocardiography anatomy, pathophysiology, instrumentation, physical principles, and advanced echocardiographic procedures. This course also addresses complex anomalies and pathological conditions of the abnormal heart. Offered winter semester. Prerequisites: RIE 330, RIE 331, RIE 320, RIE 321, and RIE 360. Corequisite: RIE 333 ...
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders ...
Ziomek, C A.; Schulman, S; and Edidin, M, "Redistribution of membrane proteins in isolated mouse intestinal epithelial cells." (1980). Subject Strain Bibliography 1980. 3374 ...
The M290 monoclonal antibody reacts with mouse CD103 also known as integrin αE (ITGAE). CD103 is an integrin protein that binds integrin beta 7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells. It has also been reported on lamina propria T cells. A subset of dendritic cells in the gut mucosa and in mesenteric lymph nodes also expresses CD103. The main ligand for CD103 is E-cadherin, an adhesion molecule expressed by epithelial cells. CD103 is thought to facilitate the interactions of T cells with epithelial cells during T cell maturation and effector functions. The M290 antibody is reported to neutralize CD103 |em|in vivo|/em|.
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begingroup$ Interesting question! @Chris has a good point. I think the relevant factor is how often a long-lived stem cell (or similar) would divide in these two tissues. Is prostate less proliferative than small intestine in this regard? Also, some cell types maintain a more differentiated state while proliferating (hepatocytes in regenerating liver, for example) and this could be a factor I think. Just some suggestions. $\endgroup$ - Roland Oct 21 16 at 8:59 ...
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Efficient absorption of the drug by the intestinal mucosal cells is of course the ultimate goal of any oral lipid-based formulation. Figure 2 shows the process
Correlation between the number of FITC-Adalimumab positive intestinal mucosal cells in inflamed gut sections and therapeutic response to Adalimumab therapy ...
Principal Investigator:TSUJIKAWA Tomoyuki, Project Period (FY):2001 - 2002, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Gastroenterology
BackgroundIntestinal intraepithelial lymphocytes (IEL) include type a T cells, i.e. the conventional MHC-restricted CD4, and CD8aß TCRaß T cells, and the type b T cells, i.e. "unconventional" T cell subsets including the CD8aa TCRaß and the TCR?d T cells. Accumulating evidence indicates an important regulatory role for CD8aa TCRaß IEL in mice and in humans, whereas TCR?d IEL appear to exert both pro-, an anti-inflammatory activities in the intestinal epithelium. Type b IEL are generally believed to be resident lymphocytes that do not recirculate once they have homed to this important T cell compartment. However, in preliminary studies we obtained evidence for an altered migration pattern of type b IEL during a potent intestinal inflammatory reaction since CD8aa TCRaß IEL may even migrate to extraintestinal sites during chronic intestinal inflammation.Working hypothesisUpon ex vivo isolation type b IEL subsets of the small and large intestine preferentially home to their sites of origin when ...
1999. gadā, salīdzinot sešus plašus Rietumu valstīs veiktus pētījumus,[30] tika konstatēts, ka mirstības rādītāji viszemākie ir zivju ēdājiem (koeficients 0,82), tiem sekoja veģetārieši (0,84) un tie, kas gaļu ēd retumis, un visbeidzot - regulāri gaļas ēdāji (1,00) un vegāni (1,00)[71]. Kad pētījumā tika iegūti precīzākie rezultāti (ņemot vērā, ka sākotnējos rezultātus ietekmēja arī tādi ar veģetārismu tieši nesaistīti faktori kā, piemēram, dzimums, vecums, alkohola lietošana, smēķēšana u.c.), mirstības koeficients veģetāriešu vidū bija 0,94[72]. Rakstā "Britu veģetāriešu mirstība"[31] norādīts, ka "britu veģetāriešiem ir zema mirstība, salīdzinot ar citām sabiedrības grupām. Pētījumā ņemot vērā tikai atšķirības gaļas ēšanā/neēšanā, viņu mirstības koeficients ir līdzīgs, kā neveģetāriešiem, kas vedina domāt, ka šī priekšrocība izskaidrojama ar citiem, uzturu nesaistītiem faktoriem, kā zems ...
Mucosa is a specialized lining tissue. It consists mainly of epithelium|columnar epithelial cells, and mainly lines the lumen|lumens of the body, such a...
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The first week of life is crucial for developing a robust intestinal mucosa and ensuring a good gut health. By feeding the intestinal cells from day 2, a novel isotonic protein drink boosts villi development, and later encourages feed consumption, with positive effects that persist up to slaughter.
The intestinal epithelium is in a dynamic equilibrium of proliferation, differentiation and apoptosis along the crypt-villus gradien. Stem cells reside in the c...
Mimoriadny jazzový úlovok sa podaril organizátorom exkluzívneho bratislavského koncertného cyklu CITY SOUNDS. V ich sieti po troch rokoch lovenia uviazla naozaj veľká ryba. Na jar sa v rámci cyklu po prvýkrát
Použité účinné látky poskytujú podľa platnej rakúskej normy ÖNORM B3802-2 resp. DIN 68800-3 požadovanú ochranu pred zamodraním (skúška podľa EN 152-1), drevokazným hubám (skúška podľa EN 113) a preventívne voči napadnutiu hmyzom(skúška podľa EN 46). Množstvo nánosu pri normových skúškach cca 200 g/m2 (uznávací certifikát č. 6/93 ...
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Staff Writer. Recent advancements in 3D printing hold incredible progress in revolutionizing the technology and medical fields. Yet scientists at the Wyss Institute for Biologically Inspired Engineering and the John A. Paulson School of Engineering and Applied Sciences at Harvard have brought their 3D printed model to the fourth dimension: time.. 4D printed objects contain an chronological element to them; that is, they respond and change in environmental stimuli by altering their shape and reconfiguring their structure over time. The researchers were inspired by the dynamic morphologies of plants. Their tissues and microstructures allow them to change shape and alter behavior depending on the external conditions, such as how a sunflower bends toward the light or how a vine climbs up structures for support.. "We set out to take a page from nature and think about the complex shape transformations that one sees in natural architectures like flowers," Jennifer Lewis, lead author on the study, ...
My piece about art blogging and Art Basel Miami is in the New Haven Advocate this week. Heres an excerpt:. "Every year in early December, the art world heads to Miami for Art Basel Miami Beach and a full range of satellite art fairs, including Pulse, Aqua, Scope, Fountain, Art Miami, and NADA (New Art Dealers Association), each presenting a segment of the art market. Art Basel Miami, located in Miami Beachs enormous convention center, is by a wide margin the biggest and most prestigious of the fairs. In large cubicles partitioned by white drywall, dealers hawk work by Picasso, Warhol, Lee Krasner and other legendary artists alongside the barely-dry work of todays art luminaries. Fueling the hype are press previews, parties on Collins Avenue, receptions, performances and confident musings about the present or future resurgence of the art market.. "This year, I went down to hold forth as a member of an art blogging panel, and the experience was considerably more gratifying than my first ...
Arginine (ARG) and nitric oxide maintain the mucosal integrity of the intestine in various intestinal disorders. In the present study, we evaluated the effects of oral ARG supplementation on intestinal structural changes, enterocyte proliferation and apoptosis following methotrexate (MTX)-induced intestinal damage in a rat. Male rats were divided into four experimental groups: Control rats, CONTR-ARG rats, were treated with oral ARG given in drinking water 72 hours before and 72 hours following vehicle injection, MTX rats were treated with a single dose of methotrexate, and MTX-ARG rats were treated with oral ARG following injection of MTX. Intestinal mucosal damage, mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined 72 hours following MTX injection. RT-PCR was used to determine bax and bcl-2 mRNA expression. MTX-ARG rats demonstrated greater jejunal and ileal bowel weight, greater ileal mucosal weight, greater ileal mucosal DNA and protein levels, greater
Hamster Small Intestinal Epithelial Cells from Creative Bioarray are isolated from small intestinal tissue of pathogen-free laboratory mice. Hamster Small Intestinal Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml and is delivered frozen. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
We present a detailed study of acute LPS-induced murine gut injury. Systemic LPS administration caused rapid IEC apoptosis and shedding in the murine small intestinal villus, and this resulted in shortening of the villus, fluid effusion into the small intestinal lumen and diarrhea.. We have characterized the dose response and kinetics of this highly dynamic phenomenon and demonstrate that it occurs within a tightly defined time period. All regions of the small intestine responded in a similar manner to LPS and in all cases apoptosis and cell shedding occurred in the apical 50% of the villus rather than exclusively at the tip. Using knockout mouse models, we confirmed that TLR4 signaling peripheral to the IEC was required, and that TNFR1-mediated signaling was essential for these events, with an NFκB2-dominant response favoring apoptosis.. Although there is an abundance of literature describing small intestinal crypt apoptosis several hours after the induction of endotoxic or septic shock (Cinel ...
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal that provides a forum for researchers and clinicians working in the areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis, and therapy of gastrointestinal diseases.
Results The mean i-FABP concentration in the second group (1.75±0.62 ng/ml) was elevated in 1.4 times compared with the first group (1.23±0.23 ng/ml). Significant high urine i-FABP concentration was observed in died infants of second group (2.39±0.88 ng/ml, p,0.05). In contrast the serum LBP level in newborns of second group was lower (23.1±4.5 ng/ml) in 1.4 time compared to newborns of first group (32.1±2.3 ng/ml).. ...
TY - JOUR. T1 - Environmental Impact on Intestinal Stem Cell Functions in Mucosal Homeostasis and Tumorigenesis. AU - Augenlicht, Leonard H.. PY - 2017/5/1. Y1 - 2017/5/1. N2 - Multiple cell compartments at or near the base of the intestinal crypt have been identified as contributing intestinal stem cells for homeostasis of the rapidly turning over intestinal mucosa and cells that can initiate tumor development upon appropriate genetic changes. There is a strong literature establishing the importance of the frequently dividing Lgr5+ crypt base columnar cells as the fundamental cell in providing these stem cell-associated functions, but there are also clear data that more quiescent cells from other compartments can be mobilized to provide these stem cell functions upon compromise of Lgr5+ cells. We review the data that vitamin D, a pleiotropic hormone, is essential for Lgr5 stem cell functions by signaling through the vitamin D receptor. Moreover, we discuss the implications of this role of ...
After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has been described so far, and it is assumed that Stx are released into the gut lumen after bacterial lysis. Human intestinal epithelium does not express the Stx receptor Gb3 or other Stx binding sites, and it remains unknown how Stx cross the intestinal epithelial barrier and gain access to the systemic circulation. This review summarises current knowledge about the influence of the intestinal environment on Stx production and release, Stx interaction with intestinal epithelial cells and intracellular uptake, and toxin translocation into underlying tissues. Furthermore, it highlights gaps in understanding that need to be addressed by future research.
Irinotecan is a common cytotoxic agent used in advanced colorectal cancers. However, a major clinical problem with this cytotoxic is that it causes gastrointestinal mucositis manifest by severe diarrhoea. To date there is no established single dose of irinotecan in rats to enable determination of changes occurring following administration. Therefore, the primary aim of this study was to determine a single dose of irinotecan that induced reproducible gastrointestinal mucositis in DA rats. The secondary aim was to determine if the presence of tumour altered the development of mucositis.Eighty-eight rats were divided into two groups, 44 received tumours and 44 remained tumour naïve. These were randomized to receive a single dose of irinotecan at 150, 200, 250 or 300 mg/kg. Two control groups of rats received either no treatment or 2 doses of 150 mg/kg irinotecan, shown previously to induce reproducible gastrointestinal mucositis. Rats were monitored closely for incidence and severity of diarrhoea, ...
TY - JOUR. T1 - Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury. AU - Kiela, Pawel R.. AU - Laubitz, Daniel. AU - Larmonier, Claire B.. AU - Midura-Kiela, Monica T.. AU - Lipko, Maciej A.. AU - Janikashvili, Nona. AU - Bai, Aiping. AU - Thurston, Robert. AU - Ghishan, Fayez K.. PY - 2009/9. Y1 - 2009/9. N2 - Background & Aims: NHE3 is a target of inhibition by proinflammatory cytokines and pathogenic bacteria, an event contributing to diarrhea in infectious and idiopathic colitis. In mice, NHE3 deficiency leads to mild diarrhea, increased intestinal expression of interferon (IFN)-γ, and distal colitis, suggesting its role in epithelial barrier homeostasis. Our aim was to investigate the role of NHE3 in maintaining mucosal integrity. Methods: Control or dextran sulfate sodium (DSS)-treated, 6- to 8-week-old wild-type (WT) and NHE3-/- mice were used for the experiments. Small intestines were dissected for further analysis. ...
TY - JOUR. T1 - Vedolizumab and early postoperative complications in nonintestinal surgery. T2 - a case-matched analysis. AU - Kotze, Paulo Gustavo. AU - Ma, Christopher. AU - Mckenna, Nicholas. AU - Almutairdi, Abdulelah. AU - Kaplan, Gilaad G.. AU - Raffals, Laura E. H.. AU - Loftus, Jr, Edward Vincent. AU - Panaccione, Remo. AU - Lightner, Amy. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Background: Vedolizumab (VDZ) is a gut-specific α4-β7 integrin antagonist that has demonstrated efficacy in Crohns disease (CD) and ulcerative colitis (UC). The safety of VDZ in the perioperative period remains unclear. The aim of this study was to evaluate postoperative complications and perioperative safety in VDZ-treated patients undergoing nonintestinal operations. Methods: A case-matched study was performed at two inflammatory bowel disease (IBD) referral centers. Adult patients with CD and UC who underwent a nonintestinal surgical procedure during treatment with VDZ were included. Patients who had their last ...
MOESM3 of Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum
British Journal of Nutrition 2017.. This paper belongs to a series of three publications that examine the intestinal barrier, its role in health and disease and the potential impact of probiotics on function. In this review, the available evidence for the role of probiotics in epithelial integrity is investigated.. Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function. Evidence is mounting that disruption of epithelial barrier integrity is one of the major etiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis (NEC), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). The notion that specific probiotic bacterial strains can impact barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are employed to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues ...
Semantic Scholar extracted view of [Morphological changes in the small intestine mucosa during cytostatic drug treatment]. by Guntram B. Wolff
Semantic Scholar extracted view of [Characteristics of the postradiation recovery of the small intestine mucosa depending on the irradiation dosage]. by V D Kudriavtsev
Have you ever published using Cynomolgus Monkey Small Intestinal Epithelial Cells? Submit your publication and earn rewards points which can be used for merchandise & discounts. Please include the product used, your name, email, publication title, author(s), PUBMED ID, Journal and issue in your submission ...
Balanced and dynamic interactions among mucus layers, intestinal epithelial cells, and microbiota, are essential for the maintenance of the intestinal mucosal homeostasis. The disruption of this balance leads to a defective mucus barrier with increased permeability that results in intestinal inflammation. The homeodomain transcription factor, Prep1, is expressed in the post-mitotic differentiated intestinal epithelial cells and is essential in embryonic development. The goal of this project is to study the involvement of Prep1 in intestinal epithelial homeostasis, and its functional role in human and experimental IBD.. ...
phdthesis{6dfbe2a0-b0a8-4145-9a6f-89d3cb82ccc9, abstract = {The intestinal surface is daily challenged with tremendous amount of foreign material derived our diet and from the commensal bacteria that densely populate the mucosal surface. Occasionally the gut mucosa is exposed to pathogens trying to enter our body. The important task of the intestinal immune system is to remain tolerant toward innocuous luminal constituents and to elicit defense responses towards invading pathogens. Conventional dendritic cells (cDC) play a central role in the initiation of such tolerogenic and defense responses. They scan and sample the local environment, migrate to the draining lymph nodes, where they activate adaptive immune cells specifically recognizing the presented luminal antigens. Several subsets of cDC populate the intestinal mucosa, but their role in the adaptive immune response is incompletely defined. The present Ph.D. thesis aimed to identify some of the in vivo functions of intestinal cDC subsets ...