Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between the nucleus and the annulus, signal intensity and intervertebral disc height. The lack of a continuous measure has made it difficult to sensitively examine degenerative disc disease. This study sought to examine the relationship between disc degeneration and intervertebral disc height. 72 community-based individuals not selected for low back pain had MRI from which the presence of lumbosacral disc degeneration was identified using the Pfirrmann grading system, and intervertebral disc height was measured. At each lumbosacral level, with higher grade of disc degeneration, intervertebral disc height was reduced (all p ≤ 0.003). Results remained unchanged when grade 5 disc degeneration, which necessitated a collapsed disc space, was excluded from analyses (all p ≤ 0.03). To quantify these
TY - JOUR. T1 - The interaction between co-cultured human nucleus pulposus cells and mesenchymal stem cells in a bioactive scaffold. AU - Wu, Chang Chin. AU - Yang, Shu Hua. AU - Huang, Teng Le. AU - Liu, Chia Ching. AU - Lu, Dai Hua. AU - Yang, Kai Chiang. AU - Lin, Feng Huei. PY - 2012/6. Y1 - 2012/6. N2 - Mesenchymal stem cells (MSCs) can differentiate into nucleus pulposus (NP) cells upon being co-cultured with NP cells. Important growth factors and morphogens secreted by MSCs during the differentiation process also enhance the biological properties of NP cells. In this study, the interactions between human NP cells and MSCs co-cultured in different cell-ratio (100% NP, 75% NP with 25% MSCs, 50% NP with 50% MSCs, 25% NP with 75% MSCs, and 100% MSCs) in a three-dimensional gelatin/chondroitin-6-sulfate/hyaluronan tri-copolymer scaffold were examined. Results showed that the cell proliferation was increased when NP and MSCs were co-cultured. Real-time PCR and immunohistochemical staining ...
The aim of this study was to determine if treatment with reversine, a purine analog, promoted generation of skeletal progenitor cells from lineage-committed annulus fibrosus cells. Reversine modulated cell growth, morphology, and the actin cytoskeleton of annulus fibrosus cells. Microarray profiling coupled with Ingenuity Pathway Analysis revealed that reversine treatment resulted in a significant expression change in many genes including those required for cell-cell interaction, cell movement, cell growth, and development. Further analysis revealed that there was involvement of gene networks concerned with cellular assembly and organization, DNA replication and repair, tissue morphology, and cell-to-cell signaling. The gene expression profile was dependent on reversine concentration. In osteogenic media, cells pretreated with 300nM reversine exhibited an increased induction in alkaline phosphatase activity and enhanced expression of alkaline phosphatase, bone sialoprotein, osteocalcin, and ...
Also known as: Disc Herniation, Lumbar / Lumbar Disc Herniations / Lumbar Disc Herniation / Prolapsed lumbar intervertebral disc (disorder) / Prolapsed lumbar intervertebral disc / Slipped lumbar disc / Intervertebral disc extrusion / Herniated disk NOS / Herniated disc / Intervertebral disc prolapse (disorder) / Slipped disc / (Intervertebral disc disorders (& [prolapsed] or [slipped]) or (disc lesion: [spine] or [cervical] or [lumbar] or [thoracic]) or (postlaminectomy syndrome) / Intervertebral disc protrusion / Intervertebral disc herniation / Prolapsed disc NOS / Intervertebral disc prolapse NOS (disorder) / (Disc displacement, site unspecified, without myelopathy) or (intervertebral disc prolapse: [NOS] or [without myelopathy]) / Intervertebral disc prolapse / Intervertebral disc bulging / (Intervertebral disc: [disorders] or [displacement] or [slipped]) or (acute back pain) ...
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification.. Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue ...
Human Nucleus Pulposus Cell MicroRNA https://www.sciencepro.com.br/produtos/sc-4807 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
TY - JOUR. T1 - Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. AU - Kim, Hyang. AU - Lee, Jeong Uk. AU - Moon, Seong Hwan. AU - Kim, Hyung Chan. AU - Kwon, Un Hae. AU - Seol, Nam Hun. AU - Kim, Ho Joong. AU - Park, Jin Oh. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Lee, Hwan Mo. PY - 2009/8. Y1 - 2009/8. N2 - Study Design.: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucleus pulposus (NP), transitional zone (TZ), and anulus fibrosus (AF) of the human intervertebral disc (IVD). Objective.: To demonstrate the differential effect of BMP-2 on DNA synthesis, proteoglycan synthesis, and osteocalcin mRNA expression in human IVD cells from the NP, TZ, and AF, respectively. Summary of Background Data.: BMP-2 has been proven to be effective in stimulating proteoglycan synthesis in articular chondrocytes and IVD cells from the NP. Nevertheless, the effect of BMP-2 on cells from different regions of the IVD has not yet been ...
The intervertebral disc (IVD) is one of the bodys most important load-bearing structures with the major mechanical force experienced in the nucleus pulposus (NP) being hydrostatic pressure (HP). Physiological levels of HP have an anabolic effect on IVD matrix metabolism in cells derived from non-degenerate animal and herniated IVD while excessive HP has a catabolic effect. However, no studies have investigated the response of non-degenerate and degenerate human disc cells derived from non-herniated discs to HP. Here we investigate the effect of physiological HP on such cells using a novel loading rig. Human IVD cells (both NP and AF) cultured in alginate were subjected to dynamic HP (0.8-1.7 MPa 0.5 Hz) for 2 h. Cell viability was assessed, RNA extracted and qRT-PCR for 18 s, c-fos, Sox-9, collagen type II, aggrecan and MMP-3 performed. Cell viability was unaffected by the loading regime. In non-degenerate NP cells, HP increased c-fos, aggrecan, Sox-9 and collagen type II (significantly so in ...
STUDY DESIGN: Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6, prostaglandin E2, and matrix metalloproteinases. The effects of endogenously produced nitric oxide on the synthesis of other mediators also were studied.. OBJECTIVES: To test the hypothesis that the cells of the intervertebral disc are metabolically active and are capable of responding to biochemical stimuli such as interleukin-1 beta in a manner that could engender degenerative changes. As part of this study, the authors also investigated some of the possible autocrine regulatory mechanisms that may operate during the biochemical responses of disc cells.. SUMMARY OF BACKGROUND DATA: The authors previously showed, for the first time, that herniated cervical and lumbar disc specimens spontaneously produce increased amounts of nitric oxide, interleukin-6, prostaglandin E2, and certain matrix metalloproteinases. These ...
The present disclosure is directed to methods for relieving pain associated with an intervertebral disc having a disc nucleus pulposus and an outer annulus fibrosus surrounding the nucleus pulposus. The method includes the steps of providing an elongated thermal or electromagnetic probe member having a flexible guidable region adjacent the distal end thereof; introducing the flexible guidable region of the probe into the annulus fibrosus of the intervertebral disc; and supplying thermal or electromagnetic energy, from an energy source, to heat or induce an electromagnetic field adjacent to the annulus fibrosus sufficient to produce a thermal or electromagnetic effect on the intervertebral disc. The flexible guidable region of the probe may be introduced at a location which is in relative close proximity to the region of intervertebral disc to be thermally or electromagnetically treated.
Degeneration of the intervertebral disc (IVD) is characterized by marked degradation and restructuring of the annulus fibrosus (AF). Although several matrix metalloproteinases (MMPs) have been found to be more prevalent in degenerate discs, their coordination and function within the context of the disease process are still not well understood. In this study, we sought to determine whether MMP-2 is associated with degenerative changes in the AF and to identify the manner by which AF cells use MMP-2. Two established animal models of disc degeneration, static compression and transannular needle puncture of rodent caudal discs, were examined for MMP-2 immunopositivity. With lentiviral transduction of an shRNA expression cassette, we screened and identified an effective shRNA sequence for generating stable RNA interference to silence MMP-2 expression in primary rat AF cells. Gelatin films were used to compare gelatinase activity and spatial patterns of degradation between transduced cells, and both
TY - JOUR. T1 - Tissue engineering of the intervertebral disc with cultured nucleus pulposus cells using atelocollagen scaffold and growth factors. AU - Lee, Kwang Il. AU - Moon, Seong Hwan. AU - Kim, Hyang. AU - Kwon, Un Hye. AU - Kim, Ho Joong. AU - Park, Si Nae. AU - Suh, Hwal. AU - Lee, Hwan Mo. AU - Kim, Hak Sun. AU - Chun, Heoung Jae. AU - Kwon, Il Keun. AU - Jang, Ju Woong. PY - 2012/3/15. Y1 - 2012/3/15. N2 - Study Design.: In vitro experiment using rabbit nucleus pulposus (NP) cells seeded in atelocollagen scaffolds under the stimulation of growth factors. Objective.: To demonstrate the effect of anabolic growth factors in rabbit NP cells cultured in atelocollagen type I and type II. Summary of Background Data.: Atelocollagen provides intervertebral disc (IVD) cells for a biocompatible environment to produce extracellular matrix. IVD cells with exogenous transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) also render an increase in matrix synthesis. ...
To read the full abstract subscribe to the JCM online archive.. Clinical effects of acupuncture following surgery in patients with prolapse of lumbar intervertebral disc, by Zhao Bin‑xiu et al. Prolapse of the lumbar intervertebral discs is clinically common. The ... SKU: a1145. ...
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks. Viability of native NP cells and delivered MSCs was maintained. Furthermore hMSCs delivered via the L-pNIPAM-co-DMAc hydrogel differentiated and produced NP matrix components: aggrecan, collagen type II and chondroitin sulphate, with integration of the hydrogel with native NP tissue. In addition L-pNIPAM-co-DMAc hydrogel injected into ...
Despite the high prevalence of intervertebral disc disease, little is known about changes in intervertebral disc cells and their regenerative potential with ageing and intervertebral disc degeneration. Here we identify populations of progenitor cells that are Tie2 positive (Tie2+) and disialoganglioside 2 positive (GD2+), in the nucleus pulposus from mice and humans. These cells form spheroid colonies that express type II collagen and aggrecan. They are clonally multipotent and differentiated into mesenchymal lineages and induced reorganization of nucleus pulposus tissue when transplanted into non-obese diabetic/severe combined immunodeficient mice. The frequency of Tie2+ cells in tissues from patients decreases markedly with age and degeneration of the intervertebral disc, suggesting exhaustion of their capacity for regeneration. However, progenitor cells (Tie2+GD2+) can be induced from their precursor cells (Tie2+GD2-) under simple culture conditions. Moreover, angiopoietin-1, a ligand of Tie2, is
TY - JOUR. T1 - ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. AU - Gonzales, Silvia. AU - Wang, Chong. AU - Levene, Howard. AU - Cheung, Herman S.. AU - Huang, Chun Yuh Charles. N1 - Publisher Copyright: © 2014, Springer-Verlag Berlin Heidelberg.. PY - 2015/2. Y1 - 2015/2. N2 - We have recently found a high accumulation of extracellular adenosine triphosphate (ATP) in the center of healthy porcine intervertebral discs (IVD). Since ATP is a powerful extracellular signaling molecule, extracellular ATP accumulation might regulate biological activities in the IVD. The objective of this study was therefore to investigate the effects of extracellular ATP on the extracellular matrix (ECM) biosynthesis of porcine IVD cells isolated from two distinct anatomical regions: the annulus fibrosus (AF) and nucleus pulposus (NP). ATP treatment significantly promotes ECM deposition and corresponding gene expression (aggrecan and type II collagen) by both cell types in ...
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.
Although histopathological grading systems for disc degeneration are frequently used in research, they are not yet integrated into daily care routine pathology of surgical samples. Therefore, data on histopathological changes in surgically excised disc material and their correlation to clinical parameters such as age, gender or body mass index (BMI) is limited to date. The current study was designed to correlate major physico-clinical parameters from a population of orthopaedic spine center patients (gender, age and BMI) with a quantitative histologic degeneration score (HDS). Excised lumbar disc material from 854 patients (529 men/325 women/mean age 56 (15-96) yrs.) was graded based on a previously validated histologic degeneration score (HDS) in a cohort of surgical disc samples that had been obtained for the treatment of either disc herniation or discogenic back pain. Cases with obvious inflammation, tumor formation or congenital disc pathology were excluded. The degree of histological changes was
K.Kato, S.Kitagava. Sapporo Higashi Tokushukai Hospital. Introduction. Surgical interventions on spine concerning hernias of intervertebral disks are one of the most spread interventions in neurosurgery. NLS may become one of the leading methods in diagnostics of intervertebral hernias and evaluation of their treatment effectiveness by surgical methods. Failure rate after herniated disks surgeries with progression of «failed» intervention syndrome is registered not less than in 10-40% cases. Some researchers believe that absence of effect in case of spinal surgery is registered not less than in 25% of cases. NLS-method allows obtaining reliable and visual images of vertebral bodies, spinal canal, intervertebral discs, ligamentous apparatus and soft tissues; it also reveals all changes in surgery area and shows reasons that caused unsuccessful treatment of disc herniation.. The purpose of given study was clarifying lumbar spine condition after operative treatment of intervertebral hernias ...
METHODS: The gene expression profiles data were obtained using the same microarray platform for two groups of patients suffering from degenerative disc diseases: GSE41883 (Human annulus disc cells exposed to TNF-a; 4 samples) and GSE27494 (Human annulus disc cells exposed to IL-1β; 4 samples). The genes that were differentially expressed in these two datasets compared to control disc cells (without cytokine exposure; 4 samples each) were identified using the R language, and were pooled using the Excel software program to select the common differentially expressed genes in the two datasets. The initial functional clustering, signaling pathways and protein-protein interaction relationship analyses were conducted using the DAVID and STRING software programs ...
Objective: This study was designed to assess the prognoses of different lumbar intervertebral disc pathologies on foot drop. Patients and Methods: We retrospectively eval..
Background: Dysregulation of microRNAs (miRNAs) has been reported to be associated with Intervertebral Disc Degeneration (IDD), and accumulating evide..
TY - JOUR. T1 - Multiphasic finite element analysis of physical signals and solute transport in the human intervertebral disc. AU - Yao, Hai. AU - Gu, Wei Yong. PY - 2004/1/1. Y1 - 2004/1/1. UR - http://www.scopus.com/inward/record.url?scp=20444477875&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20444477875&partnerID=8YFLogxK. U2 - 10.1115/imece2004-59837. DO - 10.1115/imece2004-59837. M3 - Conference article. AN - SCOPUS:20444477875. SP - 393. EP - 394. JO - Advances in Bioengineering, BED. JF - Advances in Bioengineering, BED. SN - 0360-9960. M1 - IMECE2004-59837. T2 - 2004 ASME International Mechanical Engineering Congress and Exposition, IMECE. Y2 - 13 November 2004 through 19 November 2004. ER - ...
Researchers looked specifically at the intervertebral disc, which contains three integrated structures: the inner gelatinous nucleus pulposus (NP), the outer lamellar annulus fibrosus (AF) and the cartilaginous endplates (EP) that connect the invertebral discs to the vertebral bodies. A healthy intervertebral disc is considered immune privileged, and the disc-in particular the AF-acts as a physical and biochemical barrier to inflammation and immune cell infiltration. However, during aging, degeneration and/or injury, mast cells can enter the intervertebral disc. Although scientists have documented the presence of mast cells in painful discs, the role of mast cells in low back pain and intervertebral disc degeneration is still not well understood.. Recent research published online on Oct. 2 in Scientific Reports revealed that mast cells can infiltrate intervertebral disc cells and play a key role in their degeneration.1 The investigators designed their study to better understand the presence and ...
Methods of securing an implant within an intervertebral disc are provided. In some embodiments, systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Methods of closing a defect in an anulus fibrosus of an intervertebral disc using a barrier are also provided.
This 3D medical animation depicts the anatomy of the cervical spine and a typical intervertebral disc from C3 through C7. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disc and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Question - MRI shows intervertebral disc space. How much does this affect lower back pain? . Ask a Doctor about when and why MRI is advised, Ask an Orthopaedic Surgeon
Assessment of the Possibilities of B-Mode Ultrasonography in the Diagnosis of Cervical Intervertebral Discs Hernia in Adolescents
TY - JOUR. T1 - Osmosis and viscoelasticity both contribute to time-dependent behaviour of the intervertebral disc under compressive load. T2 - A caprine in vitro study. AU - Emanuel, Kaj S.. AU - van der Veen, Albert J.. AU - Rustenburg, Christine M.E.. AU - Smit, Theodoor H.. AU - Kingma, Idsart. PY - 2018/3/21. Y1 - 2018/3/21. N2 - The mechanical behaviour of the intervertebral disc highly depends on the content and transport of interstitial fluid. It is unknown, however, to what extent the time-dependent behaviour can be attributed to osmosis. Here we investigate the effect of both mechanical and osmotic loading on water content, nucleus pressure and disc height. Eight goat intervertebral discs, immersed in physiological saline, were subjected to a compressive force with a pressure needle inserted in the nucleus. The loading protocol was: 10N (6h); 150N (42h); 10N (24h). Half-way the 150N-phase (24h), we eliminated the osmotic gradient by adding 26% poly-ethylene glycol to the surrounding ...
Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
Instrumentation for implanting an artificial intervertebral disc includes static trials and a dynamic trial for determining the appropriate size of disc to be implanted, static trial holders for manipulating the static trials, inserter/impactors for inserting and removing the static trials and for inserting the artificial intervertebral discs, repositioners/extractors for repositioning and extracting the static trials or the artificial intervertebral discs, and a leveler for setting the proper position of the artificial intervertebral disc. Methods for using the same are also disclosed. Features for artificial intervertebral discs and intervertebral spacer devices useful for manipulation by the instrumentation are also disclosed.
1. Dagenais S, Caro J, Haldeman S. A systematic review of low back pain cost of illness studies in the United States and internationally. The spine journal: official journal of the North American Spine Society. 2008;8:8-20 2. Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A. Low back pain in relation to lumbar disc degeneration. Spine. 2000;25:487-92 3. Adams MA, Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. 2000;25:1625-36 4. Hee HT, Zhang J, Wong HK. An in vitro study of dynamic cyclic compressive stress on human inner annulus fibrosus and nucleus pulposus cells. Spine J. 2010;10:795-801 5. Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY. Mechanical loading affects the energy metabolism of intervertebral disc cells. Journal of orthopaedic research: official publication of the Orthopaedic Research Society. 2011;29:1634-41 6. Wang DL, Jiang SD, Dai LY. Biologic response of the ...
Attention!!! Dear Sir or Madam! I would like to inform you of unbelievable efficacy and simplicity of protuberance or herniated pultaceous intervertebral discs repair, which can be monitored by means of magnetic resonance imaging (more). It is important to know that each nerve cell in the nervous system of animal organisms (possibly including plants) has its structural and functional memory, functional in terms of neurophysiology, needed for immanent regulation of bio cybernetic functions, among others to maintain the shape of pultaceous intervertebral discs.. Attention! If objective diagnosis reveals proturbernce or herniated pultaceous intervertebral discs even with compression on the dural sac with pain stenosis. in such case it is advisable to hold skewers between your fingers (choose the sharpest ones), and perpendicularly to the skin perform auto stimulation, triggering stimulus by means of special spatulas which are 7 centimetres wide, beginning with the adams bone, then moving down to ...
The intervertebral disc is one of the most common sources of low back pain. Intervertebral discs are structures in between the lumbar vertebrae that act as shock absorbers for the spine. They help aid trunk motion, transmit loads from one vertebral body to the next, and help protect various structures in the low back such as the lumbar vertebrae and nerve roots. The intervertebral disc is made up of two parts, the annulus fibrosus and the nucleus pulposus. The nucleus pulposus contains a gel made primarily of water and proteoglycans and acts to resist axial compression and distribute compressive forces. The annulus fibrosus is made primarily of collagen fibers and encloses the nucleus pulposus; which helps withstand tension within the disc. There are several theories as to the source of pain generation in a disc injury involving an intervertebral disc that is either degenerative or herniated. Mechanical compression and an inflammatory response is one hypothesis to explain pain from a disc ...
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
This 3D medical animation depicts the anatomy of the cervical spine and intervertebral disc. Details include orientation of the cervical spine, movements of the cervical spine, and movement of intervertebral discs. A cross-section of the intervertebral disk and spinal cord highlight the nucleus pulposus, annulus fibrosus, spinal cord, dura mater, spinal root, and spinal nerve.
Magnetic Resonance Imaging Follow-up Study on Two Cases of Lumbar intervertebral Disc Sequestration Patients Treated with Oriental Medicine Treatment;kpubs;kpubs.org
Acupuncture for the syndrome of prolapsed lumbar Intervertebral disc --Case studies and clinical experiences By Dr. Yin Hongchun Tel: Main point of diagnosis (1)
The book the lumbar intervertebral disc has not reserved. capable referral can sign from the late. If same, completely the & in its reflective excess.
1970 Dec 12;87(24):737-41. 34. Chang Y, Dennis R, Platt SR, Penderis J. Magnetic resonance imaging of traumatic intervertebral disc extrusion in dogs. Vet Rec. 2007 Jun 9;160(23):795-9. 35. Hansen HJ. A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand. 1951;20(4):280-93. 36. Olsson SE, Hansen HJ. Cervical disc protrusions in the dog. J Am Vet Med Assoc. 1952 Nov;121(908):361-70. 37. Olsson SE. On disc protrusion in dog (enchondrosis intervertebralis); study with special reference to roentgen diagnosis and to the value of disc fenestration. 1) [20]. Contrary to the well-innervated human IVDs [28], the innervation of the canine IVD tissue itself is sparse: nerve endings have only been found in the outer lamellae of the AF and not in the NP, the transitional zone, or the inner AF [29-31]. However, soft tissue structures surrounding the canine IVDs, such as the dorsal longitudinal ligament, are profusely innervated [29, 30]. 06 Gross pathology a N/A a N/A ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleus pulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues ...
Background Low back pain (LBP) may be the leading global reason behind disability and it is connected with intervertebral disc degeneration (DD) in a few individuals. and examined by multiplex cytokine assay. Interleukin-8 (IL-8) manifestation was verified by ELISA in CSF and in intervertebral discs. The SPARC-null mouse style of intensifying, age-dependent DD and persistent LBP was useful for pre-clinical validation. Man SPARC-null and control mice received systemic Reparixin, a CXCR1/2 (receptors for IL-8 and murine analogues) inhibitor, for 8?weeks. Behavioral signals of axial radiating and discomfort pain were assessed. Pursuing completion of the study, discs were excised and cultured, and conditioned media was evaluated with a protein array. Findings IL-8 was elevated in CSF of chronic LBP patients with DD compared to pain-free subjects with or without DD. Chronic inhibition with reparixin alleviated AZD-5991 S-enantiomer low back pain behaviors and attenuated disc inflammation in ...
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STUDY DESIGN: The progression of intervertebral disc degeneration (IDD) follows anterolateral stab of adult rabbit lumbar discs by 16-gauge hypodermic needle to a limited (5-mm) depth was studied for up to 24 weeks using magnetic resonance imaging (MRI).OBJECTIVES: To develop a slowly progressive, reproducible rabbit model of IDD suitable for studying pathogenesis and pathopysiology of intervertebral disc degeneration. Moreover, to improve the MRI methods and achieve improved MRIs a custom quad coil tuned and matched for 3.0T was developed. Higher SNR achievable with this coil allowed the acquisition of higher resolution images.METHODS: Part1 - The L2-L3, L3-L4, and L4-L5 lumbar intervertebral discs of 18 skeletally mature female New Zealand White (NZW) rabbits were stabbed by 16-gauge hypodermic needle to a depth of 5-mm in the left anterolateral annulus fibrosis (AF). Serial MRI scans of the stabbed discs and intact L1-2 and L5-6 control discs were performed at 3, 6, 12, and 24 weeks post ...
OBJECTIVE: To study the pathogenesis of the pain of discography and the discogenic low back pain.. METHODS: 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, and 12 physiologically aging discs and 10 normal control discs were collected to investigate the morphologic features and innervation containing neuropeptides substance P (SP), neural filament (NF), and vasoactive-intestinal peptide (VIP).. RESULTS: The distinct morphologic characteristic of the disc from the patient with discogenic low back pain was the formation of the strip zone of vascularized granulation tissue from the nucleus pulposus to the outer part of the annulus fibrosus in which there was one or several fissures. The structure of annulus fibrosus beyond the strip zone of granulation tissue was basically normal. The structures of the aging discs and the control discs showed the age-related changes. The innervation of SP, NF and VIP immunoreactive ...
Fingerprint Dive into the research topics of Potential association of metabolic and musculoskeletal disorders with lumbar intervertebral disc degeneration: Cross-sectional study using medical checkup data. Together they form a unique fingerprint. ...
BACKGROUND CONTEXT Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss. PURPOSE This study aimed to observe the effects of ALN on degenerative discs with bone loss induced by OVX in rats. STUDY DESIGN This study used controlled in vivo experiments in rodents. METHODS Thirty female Sprague-Dawley rats were randomly assigned to undergo sham surgery (n=10) or OVX surgery (n=20); 3 months later, the OVX animals were injected with either ALN (OVX+ALN, 15 µg/kg/2w, n=10) or normal saline (OVX+vehicle treatment [V], n=10). At 3 months after the ALN intervention, van Gieson staining and immunohistochemistry were used to investigate histologic and metabolic changes in the discs. Bone mineral density (BMD), micro-computed tomography, and biomechanical tests were conducted to determine the biological
Low back pain (LBP) can significantly reduce the quality of life of patients, and has a considerable economic and social impact worldwide. It is commonly associated with disc degeneration, even though many people with degenerate discs are asymptomatic. Degenerate disc disease (DDD), is thus a common term for intervertebral disc (IVD) degeneration associated with LBP. Degeneration is thought to lead to LBP because of nerve ingrowth into the degenerate disc, inflammation, or because degradation of extracellular matrix (ECM) alters spinal biomechanics inappropriately. Thus, while the objectives of some interventions for LBP are to control pain intensity, other interventions aim to deal with the consequences of disc degeneration through stabilizing the disc surgically, by inserting artificial discs or by repairing the disc biologically and preventing progressive IVD degeneration. Despite tremendous research efforts, treatment of LBP through the use of regenerative interventions aiming to repair the IVD is
In this study, we showed that people with an Sp1 polymorphism of the COLIA1 gene had an increased risk of intervertebral disc degeneration. In addition, we examined the association between COLIA1 Sp1 polymorphism and osteoporosis. Although, our results indicate that male carriers of the T allele had higher levels of serum OC, the COLIA1 Sp1 polymorphism did not seem to be related to any other indicator of male osteoporosis. In women, none of the outcome measures of osteoporosis was found to be associated with this studied polymorphism.. Although several recent studies have focused on the association of the COLIA1 Sp1 polymorphism with osteoporosis, until now not much attention has been given to the relation of this genotype with disc degeneration. As far as we know this is the first study to have demonstrated an association between the COLIA1 Sp1 polymorphism and an increased risk of disc degeneration. Although the number of respondents with disc degeneration in this sample is relatively small, ...
Objective: to evaluate plasma vitamin D and cross-linked C-telopeptides of type I (CTx-I) and type II (CTx-II) collagen concentrations in males with lumbar intervertebral disc degeneration (IVD) compared to healthy controls. Improved knowledge might suggest to optimize the vitamin D status of IVD patients and contribute to clarify mechanisms of cartilage degradation. Methods: 79 Italian males with lumbar IVD assessed by Magnetic Resonance Imaging (MRI) and 79 age, sex and BMI-matched healthy controls were enrolled. Plasma 25hydroxyvitamin D (25(OH)D), CTx-I and CTx-II were measured by immunoassays. Circannual seasonality, correlation between biomarkers concentrations and clinical variables were assessed. Results: overall subjects 25(OH)D and CTx-II showed month rhythmicity with acrophase in August/September and October/November, and nadir in February/March and April/May, respectively. An inverse correlation between 25(OH)D and CTx-I, and a direct correlation between CTx-II and CTx-I were ...
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Currently, herniated nucleus pulposus (HNP) with radiculopathy and other preconditions are regarded as relative or absolute contraindications for lumbar total disc replacement (TDR). In Switzerland it is left to the surgeons discretion when to operate. The present study is based on the dataset of SWISSspine, a governmentally mandated health technology assessment registry. We hypothesized that preoperative nucleus pulposus status and presence or absence of radiculopathy has an influence on clinical outcomes in patients treated with mono-segmental lumbar TDR. Between March 2005 and April 2009, 416 patients underwent mono-segmental lumbar TDR, which was documented in a prospective observational multicenter mode. The data collection consisted of perioperative and follow-up data (physician based) and clinical outcomes (NASS, EQ-5D). Patients were divided into four groups according to their preoperative status: 1) group degenerative disc disease (DDD): 160 patients without HNP and no radiculopathy, classic
Introduction: MiR-202-3p is involved in the pathogenesis of intervertebral disc degeneration (IDD) via regulating MMP-1 expression in neuronal precursor cells (NPCs). As an activator of miR-202-3p and KDM6A expression, metformin (MET) may regulate the expression of SOX9 via regulating the...
Intervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis or paralysis. Mortality rate is high and some cases are left with permanent disability even after treatment. Aims of this study were twofold: Firstly, to investigate whether neutering, i.e. gonadectomy, is associated with increased risk of IVDH in dachshunds, and secondly to investigate whether age of neutering alters risk of IVDH in this breed. Information was obtained for 1964 dachshunds from the owner survey,
Dr Uday Doctor in Pearland, Beaumont and Houston, TX offers lumbar facetectomy or foraminotomy. He treats obstructed neuroforamen, bone spurs and herniated intervertebral disc.
A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
With degenerative disc disease, the main problem lies within one or more of the intervertebral discs. There is a disc between each of the vertebra in your spine. The intervertebral discs are designed to absorb pressure and keep the spine flexible by acting as cushions during body movement. The discs are similar to shock absorbers. Without the cushion effect of the discs, the vertebrae in your spine would not be able to absorb stresses, or provide the movement needed to bend and twist. Bones cannot sustain high stress repeatedly without being damaged. Much of the mechanical stress of everyday movements is transferred to the discs.. A healthy intervertebral disc has a great deal of water in the nucleus pulposus - the center portion of the disc. The water content gives the nucleus a spongy quality and allows it to absorb spinal stress. Excessive pressure or injuries to the disc can cause the injury to the annulus - the outer ring of tough ligament material that holds the vertebrae together. ...
This study examined the ability of the extreme lateral interbody fusion (XLIF) procedure to restore coronal and sagittal alignments for patients with adult spinal deformity (ASD) using computed tomography multiplanar reconstruction (CT-MPR). Thirty-eight patients with ASD undergoing correction and fixation with XLIF at 114 levels were studied. The coronal segmental Cobb angle, coronal regional Cobb angle (L1-5), sagittal segmental Cobb angle, sagittal regional Cobb angle (L1-5), intervertebral disc height and, vertebral body rotation (VBR) were measured before and after of XLIF surgery using CT-MPR. The mean sagittal segmental Cobb angle, the coronal segmental Cobb angle and VBR were corrected from 5.0° to 9.0°, from 6.3° to 4.3° and from 12.2° to 10.8°, respectively. The mean of the intervertebral disc heights increased significantly from 6.0 mm to 10.4 mm postoperatively. Although increases in coronal segmental Cobb, sagittal segmental Cobb, and intervertebral disc height at each level were
Lumbar total disc replacement surgery in Korea can be a cost saving option for people who are not able to pay for it in their own country. Medical Tourism Co is offering pre-screened quality healthcare facilities for artificial disc replacement surgery in Korea.. Please submit quote request form on right for price estimate.. ...
Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.
Objective: To determine efficacy of radionucleoplasty infiltration in intervertebral disc herniation Background of Background Data: Radionucleoplasty is a new, minimally invasive procedure for the treatment of disc prolapse. The aim of the present study was to determine associations between the morphology of the basic disease, patient-specific factors and the outcome of the treatment.Disc prolapse is one of the important causes of low back pain radiating to limbs. Apart from conservative therapy all other forms of treatment aim at decompressing the nerve roots. These can be done by taking the disc out by surgery or by decompressing the foramen and disc by different interventions. The various treatment options have confused clinicians due to significant failure rate associated with different kinds of surgeries as well as with different interventions. Injecting a thermal wand fordisc prolapsehas developed as an alternative to chemonucleolysis and disc surgery owing to its high success rates, less ...
Platelet-rich plasma was effective in stimulating cell proliferation and extracellular matrix metabolism. The response to platelet-rich plasma was greater in the case of anulus fibrosus cells than of nucleuspulposus cells. The local administration of platelet-rich plasma might stimulate intervertebral disc repair. In addition, given the risks of using animal serum for tissue engineering, autologous blood may gain favor as a source of growth factors and serum supplements needed for stimulating cells to engineer intervertebral disc tissues. (Akeda et al Spine 2006 ...
椎間円板の変性は、背痛および世界的な障害の主要な原因に大きく寄与する。椎間板変性の多くの動物モデルが存在する。一貫した椎間板損傷および再現性のある椎間板変性を達成するドリルビットを利用して、椎間板変性のヒツジモデルを実証する。...
Replacement of Spinal Disc surgery is also popularly known as intervertebral disc athroplasty or total disc replacement. This process involves the spine getting replace with artificial made like metal or plastic ones both in the upper or lower spine. This surgery is done to treat chronic and severe cervical and lumbar pain which results from DDD or Degenerative Disc Disorder.. This procedure is a new one for several types of lumbar pain. Just recently this process is approved by FDA in the United States and research is ongoing worldwide especially in Europe. This might become a standard cure for some lower back pains.. Artificial disc replacement surgery is done to remove and lessen pain while promoting flexibility in the spine. Those who are qualified to have spinal disc replacement surgery are the following;. ...
Science & Technology, Life Sciences & Biomedicine, Biochemical Research Methods, Biochemistry & Molecular Biology, Mesenchymal stem cell (MSC), Regenerative medicine, Tissue engineering, Low back pain (LBP), Intervertebral disc (IVD), IVD degeneration, Biological therapy, Cellular therapy, Articular cartilage, Osteoarthritis (OA), Umbilical cord, Whartons Jelly stem cell (WJSC), Adipose-derived stem cell (AD-MSC), HUMAN UMBILICAL-CORD, LOW-BACK-PAIN, NECROSIS-FACTOR-ALPHA, PLATELET-RICH PLASMA, PULPOSUS-LIKE CELLS, IN-VITRO, NUCLEUS PULPOSUS, PROGENITOR CELLS, STROMAL CELLS, LUMBAR DISC ...
Degeneration of the intervertebral discs is a normal part of aging. However, in some patients, disc degeneration occurs early or more severely than is normal. In some cases, the degeneration of the intervertebral discs can lead to severe, chronic pain.. Degenerative disc disease can manifest as various symptoms. It is a common misconception that only the elderly are affected by DDD. However, this is not the case; DDD can affect younger individuals as a result of injury or other variables. In many patients suffering from degenerative disc disease, the pain is reported as a pins and needles type of sensation. The pain can be exacerbated by daily activities such as sitting down, bending, or reaching. Any dull, aching pain that is localized in the lower back requires the attention of a physician at the soonest available time. In the event that an appointment isnt immediately available, DDD patients often experience relief when they lay down in the prone or supine positions. This position ...
TY - JOUR. T1 - Effect of intradiscal electrothermal treatment with a short heating catheter and fibrin on discogenic low back pain. AU - Derby, Richard. AU - Kim, Byung Jo. PY - 2005/7. Y1 - 2005/7. UR - http://www.scopus.com/inward/record.url?scp=20544467947&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=20544467947&partnerID=8YFLogxK. U2 - 10.1097/01.phm.0000167619.84014.fb. DO - 10.1097/01.phm.0000167619.84014.fb. M3 - Article. C2 - 15973093. AN - SCOPUS:20544467947. VL - 84. SP - 560. EP - 561. JO - American Journal of Physical Medicine and Rehabilitation. JF - American Journal of Physical Medicine and Rehabilitation. SN - 0894-9115. IS - 7. ER - ...
Degenerative disc disease (DDD) describes the natural breakdown of anintervertebral disc of the spine. Despite its name, DDD is not considered a disease, nor is it progressively degenerative. On the contrary, disc degeneration is often the effect of natural daily stresses and minor injuries that cau
An intervertebral disk prosthesis system, which is used for forming an artificial intervertebral disk and comprises a first and a second prosthesis component wherein each of the two prosthesis components comprises a first and a second vertebral body contacting element for placement on neighboring vertebral bodies bounding an intervertebral disk space of a spinal column and a joint element that is mounted between and is moveable relative to at least one of the first and second vertebral body contacting elements, attains a substantially natural range of motion independent of the positioning of the two prosthesis components relative to each other and to the neighboring vertebral bodies. Each prosthesis component has a ball joint formed between the first and second vertebral body contacting elements.
Surgical options to reduce the pain of DDD include:. Discectomy: the surgical removal of herniated disc material that presses on a nerve root or the spinal cord. The procedure involves removing the central portion of an intervertebral disc, the nucleus pulposus, which causes pain by stressing the spinal cord or radiating nerves.. Laminectomy: surgery that creates space by removing the lamina - the back part of the vertebra that covers your spinal canal. Also known as decompression surgery, laminectomy enlarges your spinal canal to relieve pressure on the spinal cord or nerves.. Spinal fusion: a neurosurgical or orthopedic surgical technique that joins two or more vertebrae. This procedure can be performed at any level in the spine (cervical, thoracic, or lumbar) and prevents any movement between the fused vertebrae.. Lumbar Total Disc Replacement: With artificial disc replacement, pain relief is brought about by removal of the painful disc and motion is maintained with the use of a prosthetic ...
Discogenic low back pain remains a difficult lumbar syndrome to treat. Recently developed electro-thermal technology permits precise tissue temperature control, steerability, and controlled lesion production in collagenous tissue. This novel treatment permits targeted shrinkage of annular and nuclear disc collagen (collagen shrinkage has been reported in the literature) and may preserve disc function without tissue necrosis or the need for fusion. It may also be useful in the ablation of pain sensing nociceptors.. ...
Looking for online definition of passive physiologic intervertebral movements in the Medical Dictionary? passive physiologic intervertebral movements explanation free. What is passive physiologic intervertebral movements? Meaning of passive physiologic intervertebral movements medical term. What does passive physiologic intervertebral movements mean?
There are 3 main types of disc injuries. The first disc injury consists of annular fiber tears which do not extend to the outer aspects of the disc. Thus, the inner nuclear material is prevented from completely escaping the disc. The second type of disc injury, commonly referred to as a disc herniation, consists of annular tears which run from the innermost aspects of the annulus (where the nucleus is) to the outermost aspects of the annulus. In this type of injury, the pressurized nuclear material can squeeze through the tears in the annulus and escape to the outside of the disc. When this occurs, the nuclear material may come in contact with nearby spinal nerves and even the spinal cord. In the third type of disc injury, referred to as a disc bulge, the inner nucleus loses hydration; common in those with prolonged spinal stress and the elderly. This results in bulging of the disc much like a tire bulges when it contains inadequate amounts of air. Similar to the previous injury, the nearby ...
While a single-level fusion is in and of itself a major surgery, a multi-level fusion has significantly more potential risks and complications associated with it and should be considered only in rare instances.. While it is a major surgery, fusion surgery can be an effective option for patients to enhance their activity level and overall quality of life. This potential positive outcome is particularly true now that less invasive surgical techniques are available to decrease post-operative discomfort, preserve more of the normal anatomy of the low back, and result in higher rates of fusion than previous techniques.. Lumbar Artificial Disc Replacement Surgery. A newer surgery to treat pain and disability from lumbar degenerative disc disease is artificial disc replacement. The theory is that replacing the disc, instead of fusing the disc space together, maintains more of the normal motion in the lumbar spine, thereby reducing the chance that adjacent levels of the spine will break down due to ...
Degenerative disc disease causes low back pain in two different ways. First, the nerve roots can be pinched as a direct result of degenerative disc disease. A nerve root exits the spinal canal through a small hole called the foramen. The height of the foramen is determined, to a great degree, by the height of the disc. When discs degenerate, they lose height. As a result, when discs degenerate, the foramen loses height. If the space for the nerve root in the foramen gets tight enough the nerve root and become pinched and painful. When this occurs you feel leg pain more than back pain.. Degenerative disc disease can also cause back pain itself. The reason is a little bit complicated. The disc is composed of two parts: a very tough outer part, and an inner gel. Because the inner part of the disc is made out of a gel, it does not have its own blood supply. (Fun fact, the disc is the largest structure in the human body that does not have its own blood supply.) The way your body knows what is part of ...
Is degenerative disc disease work related, even if it results in low back surgery and permanent work restrictions? This second part blog continues the discussion of work-related degenerative disc disease. Yes, if a traumatic work accident caused the degeneration to accelerate beyond normal progression or if the degeneration itself was contributed to by your job duties over time. Your workers compensation attorney must have a sincere understanding of the medicine involving low back degenerative disc disease which can lead to low back disability, permanent work restrictions, and loss of earning capacity.. The nucleus may push through the torn annulus and into the spinal canal. This is called a herniated or ruptured disc. The disc material that squeezes out can press against the spinal nerves. The disc also emits enzymes and chemicals that produce inflammation. The combination of pressure on the nerves and inflammation caused by the chemicals released from the disc cause pain.. As the degeneration ...
Degenerative disc disease is one of the most common causes of low back pain, yet can also be one of the most misunderstood and difficult to diagnose. It is the single most common diagnosis related to serious back pain and neck pain, and tends to occur more frequently with age. As a person ages, the discs can become brittle, susceptible to hemiation, and all together less durable. The main causes of degenerative disc disease are age, family history, lifestyle and age. It is most often reported in patients over 35. Lifestyle is particularly important, individuals who frequently lift heavy items may expose their spine to trauma. Repetitive shock can also promote the development of degenerative discs over time. Degenerative disc disease can be a confusing diagnosis for many patients, and mainly due to the terms Degenerative and Disease, as it is not strictly degenerative or progressive, and it is not really a disease, but rather a condition that produces pain caused by the damaged disc. ...
Interventional Spine announced FDA clearance of its Lateral Opticage Expandable Intervertebral Body Fusion Device. This device joins the Interventional Spine family of Opticage Expandable Interbody Fusion Devices previously cleared for TLIF earlier this year, and used with the Companys PerX360 System.. The Opticage Expandable Intervertebral Body Fusion Device is a lumbar intervertebral body fusion device and is indicated for use with autogenous bone graft in patients with degenerative disc disease (DDD) at one or two contiguous levels from L2-S1. The Opticage Expandable Interbody Fusion Device can be implanted via posterior, transforaminal or lateral approach.. Mr. Walter A. Cuevas, Chief Executive Officer of Interventional Spine said: With this milestone, Interventional Spine continues to lead the spine market in providing the most innovative solutions for surgeons, which in the end, benefit patients. This new indication for the Opticage Expandable Interbody Fusion Devices broadens the ...
Back pain is a common complaint and the origin of this frequently attributed to degenerative disc disease. In the most severe cases, the integrity of the disc and surrounding tissue is lost to such an extent that surgical intervention is necessary. Fusion procedures are commonly used to treat severely degenerated discs. Yet this is known to alter the biomechanics of the operated level, and may create a progression of degenerative decline. Total disc replacement has emerged as a viable treatment but the complexity of the spine is reflected in the clinical results, which trail far behind the success of hip and knee arthroplasty. This may be due to a failure of total disc replacement procedures to restore the natural biomechanics of the spine. The present study has led to the development of a dynamic pre-clinical testing protocol to quantitatively assess the efficacy of disc replacement devices. A six-axis spine simulator was designed and built, and the stiffness matrix testing of porcine lumbar ...
Discectomy refers to the removal of total or a part of an intervertebral disc. Anterior cervical discectomy is a surgical procedure offered at Illinois Spine Institute in Crystal Lake, IL.
The research literature concerning disc degeneration is particularly diverse, and there are no accepted definitions to guide biomedical research, or medicolegal practice.
Deflection images of living outer Annulus cells from Bovine Intervertebral discs, day 6 (after seeding), imaged in culture medium containing 10% fetal bovine serum (FBS) using Contact Mode. Left image was acquired before a series of force curves were taken on the area of the cell that is circled in red. Right image was acquired 45 minutes later. Displayed force curve was acquired on the cell marked with an X. It can be clearly seen that the cells have moved, undergone cytoskeletal reorganization and, where the force curves were taken, were damaged by the AFM tip, 54µm.. Data Courtesy of Y. Dror and J. Klein, Oxford University and Weizmann Institute, NanoInteract consortium.. ...
Our neurosurgical team adopts the finest of spinal surgical practices for patient comfort. There are many artificial disc methods typically classified into two general types: total disc replacement and disc nucleus replacement. In a total disc replacement, all or most of the disc tissue is removed and a replacement device is implanted into the space between the vertebrae. With a disc nucleus replacement, only the center of the disc is removed and replaced with an implant. The outer part of the disc is not removed. By removing disc tissue and eliminating movement, the pain will be significantly reduced.. Complexities of artificial disc replacement ...
Purpose Abnormal stress in the lumbar vertebra, also known as bony stress, can be a precursor to degenerative changes which may manifest as low back pain (LBP). However, the prevalence of bony stress...
Twelve dogs were divided into two equal groups and given lumbar intradiscal injections of 10, 50, or 100 U/ml of chondroitinase ABC reconstituted in sodium acetate buffer. Radiographs of the lumbar spine were made before and after surgery in both groups. Additional films were made at 5 days after su …
Lumbar disc disease (LDD) is among the most common ailments in Western societies.1 In the military, LDD often results in significant impairments and contributes greatly to health care costs and disability.2 Military training often results in exacerbation or presentation of LDD related symptoms. LDD appears to be a multifactorial disorder in which genetics play an important role, as it is evident from several recent studies.3. Collagen is the most abundant structural component of the extracellular matrix. Changes in collagen cross linking have been identified in degenerative disc disease, and LDD was recently associated with a polymorphism of the collagen type IX (COL9A3) gene.3 Type I collagen is the major protein in skin, ligaments, and bone; both COL1A1 and COL1A2 are present in the main components of the intervertebral disc, the annulus fibrosus (primarily) and the nucleus pulposus (secondarily).4. A G→T polymorphism within the COL1A1 regulatory region that affects the recognition site for ...
Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Hypoxia and low pH stressed disc conditioned medium promotes hypersensitivity of peripheral sensory neurons. ORS PSRS 5th Symposium, Skytop PA (US), Nov 3-7, 2019 (poster). Stefanoska D, Ma J, Grad S, Alini M, Peroglio M. Effects of glucose concentration and pH on dorsal root ganglion neurite outgrowth. Pain in EU XI EFIC, Valencia (Spain), Sep 4-7, 2019 (e-poster). Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Effect of pH and oxygen tension on dorsal root ganglion calcium response to bradykinin and neurite sprouting. Pain in EU XI EFIC, Valencia (Spain), Sept 4-7, 2019 (poster). Ma J, Stefanoska D, Hildebrand M, Zeiter S, Alini M, Peroglio M. Validation of cell line models to study intervertebral disc neo-innervation associated with discogenic pain. Swiss 3R Day, Bern (CH), Sept 2, 2019 (poster).. Ma J, Stefanoska D, Grad S, Alini M, Peroglio M. Low pH culture of dorsal root ganglion cells as an in vitro model to study pathological changes ...
What is an intradiscal PRP injection and how can it help?. Injection of platelet rich plasma (PRP) is still considered an experimental treatment, although evidence for its effects are mounting. PRP can induce inflammation and healing in the tissue in which it is injected, and has beneficial effects in treating other painful conditions. Recent studies have shown there to be evidence that PRP may be beneficial in patients with degenerative disc disease. With the assumption that inflammation and degeneration are the cause of disc related pain, we inject a small amount of PRP into the nucleus pulposus of the intervertebral disc.. Approximately 40% of low back pain is thought to come from the intervertebral disc disease. As we age, or through trauma and accidents, the discs become damaged. As they become damaged, and through tears in their outer layers, they lose their functional integrity and hydration, leading to the in growth of pain sensing nerves. This is often referred to as discogenic ...
Degenerative disc disease info, Degenerative disc disease or DDD is a spinal condition caused by the breakdown of your intervertebral discs. Symptoms, causes, diagnosis, treatment options.
and cauda equina symptoms is disc height loss. As the disc wears there is loss of disc height and an increased likelihood of the ��� Learn more about the various symptoms and treatment options for Lumbar Degenerative Disc Disease from our spine specialists in NJ and NY. Discs act as natural shock absorbers in the spine, so when they are damaged, it can cause pain. Nonsurgical Treatment for Degenerative Disc Disease. MD. Thanks for the A2A. The discs also may bulge into the spinal canal. These issues can be debilitating and affect people throughout their lives. ... inducing a significant post-operative loss of disc height. Author information: ( Question: Im overweight, and Ive had severe back pain caused by a herniated disc. A disc injury is among the most common types of back ailments. 1. Hypothesis evaluation. Greater volumes of disc removal were associated with accelerated disc height loss. I have had two herniations that required laminectomies and one herniation that did not. 1 thank. ...