Saez de Urabain, Irati R. (2015) Investigating the mechanisms underlying fixation durations during the first year of life: a computational account. PhD thesis, Birkbeck, University of London. Sahiti, Fadil (2015) Factors that enable and constrain the growth of firms : the case of Kosovo. PhD thesis, Birkbeck, University of London. Sastry, Deepti (2015) Environmental capital as cultural capital : environmentalism and identity-formation in the Indian middle class. PhD thesis, Birkbeck, University of London. Scipioni, Marco (2015) Delegation to the European Commission in EU migration policy : expertise, credibility, and efficiency. PhD thesis, Birkbeck, University of London. Score, Melissa Jean (2015) The development and impact of campaigning journalism in Britain, 1840-1875 : the old new journalism? PhD thesis, Birkbeck, University of London. Siridetkoon, Pitchayapa (2015) Motivation, anxiety and international posture of multiple language learners in Thailand. PhD thesis, Birkbeck, University of ...
The emerging role of the IL-4/IL-3 cytokine receptor IL-4Ralpha in asthmaDailyUpdates 9th July: Analysts have recently predicted that the market for airway inflammatory diseases will increase by 35% to over $18 billion by 2011. A recent target evaluation report produced for the drug development sector concluded tha...
The IL-23 Bioassay is a biologically relevant MOA-based assay that can be used to measure the potency and stability of antibodies and other biologics designed to stimulate or inhibit interactions with the IL-23 receptor (IL-23R).
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Home » Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ ...
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Although innate lymphoid cells (ILCs) functionally analogous to T helper type 1 (Th1), Th2, and Th17 cells are well characterized, an ILC subset strictly equivalent to IL-10-secreting regulatory T cells has only recently been proposed. Here, we report the absence of an intestinal regulatory ILC population distinct from group 1 ILCs (ILC1s), ILC2s, and ILC3s in (1) mice bred in our animal facility; (2) mice from The Jackson Laboratory, Taconic Biosciences, and Charles River Laboratories; and (3) mice subjected to intestinal inflammation. Instead, a low percentage of intestinal ILC2s produced IL-10 at steady state. A screen for putative IL-10 elicitors revealed that IL-2, IL-4, IL-27, IL-10, and neuromedin U (NMU) increased IL-10 production in activated intestinal ILC2s, while TL1A suppressed IL-10 production. Secreted IL-10 further induced IL-10 production in ILC2s through a positive feedback loop. In summary, ILC2s provide an inducible source of IL-10 in the gastrointestinal tract, whereas ...
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The risk of children having asthma was high when fathers have started smoking at the age of 15. The time of quitting before consumption did not decrease asthma risk.
TY - JOUR. T1 - Requirement for neuropeptide Y in the development of type 2 responses and allergen-induced airway hyperresponsiveness and inflammation. AU - Oda, Naohiro. AU - Miyahara, X. Nobuaki. AU - Taniguchi, Akihiko. AU - Morichika, Daisuke. AU - Senoo, Satoru. AU - Fujii, Utako. AU - Itano, Junko. AU - Gion, Yuka. AU - Kiura, Katsuyuki. AU - Kanehiro, Arihiko. AU - Maeda, Yoshinobu. PY - 2019/3. Y1 - 2019/3. N2 - Neuro-peptide Y (NPY) is a neurotransmitter that is widely expressed in the brain and peripheral nervous system. Various immune cells express the NPY Y 1 receptor. NPY modulates these cells via its Y 1 receptor; however, involvement of NPY in the pathophysiology of bronchial asthma, particularly airway hyperresponsiveness (AHR), has not been defined. NPY-deficient and wild-type mice were intranasally sensitized and challenged to house dust mite (HDM) extract, and airway responses were monitored. After sensitization and challenge, NPY-deficient mice showed significantly lower AHR ...
Room 4137 Aloke Virmani Finn, MD Associate Professor of Medicine, University of Maryland Alternative Macrophages, Angiogenesis, and Plaque Progression in Atherosclerosis
Certain foods increase mucus production or thicken existing mucus. Steer clear of the foods in this article to avoid chronic mucus problems.
有多种机制认为病毒感染与过敏性炎症相互作用,从而导致下呼吸道功能障碍、喘息和哮喘。首先,潜在的过敏性炎症可以直接增强气道对鼻病毒感染的反应性。此外,病毒感染可损害气道上皮的屏障功能,导致气道壁对气传过敏原的吸收增加和炎症反应增强,而潜在的过敏性炎症也可能导致病毒复制增强。值得注意的是,鼻病毒感染和变应原均可促进气道上皮细胞产生IL-33, IL-33是最近发现的一种先天细胞因子,可促进2型气道炎症和重塑。据报道,这种类固醇耐药途径在难以控制哮喘的儿童中上调。有趣的是,IL-33多聚物与中晚期发作的喘息有关,而中晚期发作的喘息与早期生活中的过敏反应密切相关。 另一种先天上皮细胞因子IL-25也由鼻病毒诱导,在过敏患者鼻病毒感染的情况下,IL-25可能加重过敏性气道炎症 ...
Инфламмасома - важный компонент нативного иммунитета. Она представляет собой макромолекулярный комплекс, включающий сенсорные элементы, адапторные белки и зимоген каспазы-1. Под действием продуктов распада тканей и патогенных микроорганизмов инфламмасома активируется и превращает про-IL-1b и про-IL-18 в активные интерлейкины. Активация инфламмасом отмечена при многих воспалительных заболеваниях и служит мишенью для терапевтических воздействий. В настоящем обзоре обсуждается вклад инфламмасом в патогенез социально-значимых заболеваний ...