TY - JOUR. T1 - Engineered T regulatory type 1 cells for clinical application. AU - Gregori, S. AU - Roncarolo, MG. PY - 2018. Y1 - 2018. N2 - T regulatory cells, a specialized subset of T cells, are key players in modulating antigen (Ag)-specific immune responses in vivo. Inducible T regulatory type 1 (Tr1) cells are characterized by the co-expression of CD49b and lymphocyte-activation gene 3 (LAG-3) and the ability to secrete IL-10, TGF-β, and granzyme (Gz) B, in the absence of IL-4 and IL-17. The chief mechanisms by which Tr1 cells control immune responses are secretion of IL-10 and TGF-β and killing of myeloid cells via GzB. Tr1 cells, first described in peripheral blood of patients who developed tolerance after HLA-mismatched fetal liver hematopoietic stem cell transplantation, have been proven to modulate inflammatory and effector T cell responses in several immune-mediated diseases. The possibility to generate and expand Tr1 cells in vitro in an Ag-specific manner has led to their ...
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
Purified anti-human/mouse IL-21 Antibody - Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases..
IL10 Signaling Pathways information: Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is a cytokine with potent anti-inflammatory properties, re
Objective: This study evaluated the expression of pro-inflammatory (IL-1 beta, IL-6, IFN-gamma and TNF-alpha) and anti-inflammatory (IL-4 and TGF-beta ...
TY - JOUR. T1 - Plasma levels of the immunomodulatory cytokine interleukin-10 during normal human pregnancy: a longitudinal study. AU - Holmes, VA. AU - Wallace, Julie. AU - Gilmore, WS. AU - McFaul, P. AU - Alexander, HD. PY - 2003/3. Y1 - 2003/3. N2 - Pregnancy is proposed to be a Th2 phenomenon, where Th2 cytokines inhibit Th1 responses to improve foetal Survival. The importance of interleukin-10 (IL-10), an immunomodulatory cytokine produced by Th2 cells, in the maintenance of normal pregnancy is becoming increasingly apparent. In a longitudinal case-control study, the physiological effect of pregnancy on plasma IL-10 was investigated. The plasma concentration of IL-10 was determined using an ELISA technique in 99 pregnant women sampled at 12. 20 and 35 weeks of gestation, 38 non-pregnant control subjects sampled in parallel and in a subgroup of women sampled at 3 days post-partum (it. pregnant 21, non-pregnant 21). Plasma IL-10 was significantly higher in pregnant women at 12, 20 and 35 ...
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the worlds most successful human bacterial pathogen. Lung granulomas are the pathologic hallmark of TB. The cellular components of the granulomas play an important role in containment and progression of Mtb infection. The balance of pro and anti-inflammatory cytokines within granulomas is associated with reduction in bacterial burden. IL-27 is an immunomodulatory cytokine that modulates T cells. The properties of IL-27 as an enhancer or silencer of inflammation are yet to be evaluated in the context tuberculosis in a non-human primate (NHP) model. We used macaques, a NHP model that recapitulates human TB, to characterize the expression and modulatory effects of IL-27, especially at an individual granuloma level. In this preliminary evaluation, we characterized the cell types producing IL-27 in response to Mtb and in granulomas and correlated IL-27 production with pro and anti-inflammatory cytokines such as ...
Neutrophils are among the first responders at sites of infection and are an essential arm of the innate immune system. They attack invading pathogens through a number of mechanisms, including phagocytosis and the release of lytic enzymes and reactive oxygen species, leading to an acute proinflammatory response (see commentary by Cassatella et al.). Zhang et al. investigated the responses of mouse neutrophils to bacteria and various agonists of pattern-recognition receptors, such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs). Whereas individual TLR agonists (particularly Pam3, which stimulates TLR2) activated neutrophils in vitro, they did not induce the production of proinflammatory cytokines; rather, they stimulated neutrophils to produce small quantities of the anti-inflammatory cytokine interleukin-10 (IL-10). Exposure of neutrophils to bacteria resulted in the production of much greater amounts of IL-10, which led the authors to investigate which other signals might ...
In the original report describing GAG [7], it was shown that GAG has anti-inflammatory effects in mice. However, the mechanism through which GAG elicits its immunomodulatory effects remained a question at that time. In the present study, we demonstrate that GAG induces its anti-inflammatory effects by inducing the potent anti-inflammatory cytokine IL-1 receptor antagonist.. IL-1Ra can inhibit the activation of the IL-1 pathway by binding to the IL-1R type 1 receptor and prevents recruitment of the IL-1R accessory protein that is required for signalling. It has been repeatedly shown that IL-1 is an essential proinflammatory cytokine of the innate immunity. A deficient IL-1 pathway is also detrimental for the host, since it is an important protective pathway required to fight infection [17]. Thus the IL-1 axis is a potent pro-inflammatory pathway that needs to be tightly regulated, and IL-1Ra is a crucial player in this regulation. Therefore, it is rather surprising that the role of IL-1Ra in ...
Results In the cytokine profile of HIV-1 infected people the increased levels of pro-inflammatory cytokine TNF-α compared to controls (group I - (0.77 ± 0.08), group II - (2.34 ± 0.69), healthy controls - (0.51 ± 0.32) pg/mL, p , 0.05) and the anti-inflammatory IL-10 (group I - (3.99 ± 0.99), group II - (20.08 ± 0.44), healthy controls - (1.68 ± 0.32) pg/mL, p , 0.001) were demonstrated. No significant difference in IL-4 between surveyed troops and comparison group was found.. Patients with CD4 T lymphocyte levels ≤ 200 cells/µL showed significantly higher plasma concentration of TNF-α and IL-10 compared with the group I (p , 0.05). Among HIV-1 infected from group II mean serum concentrations of TNF-α higher than that of group I in 3 times (p , 0.05). A significant increase in the concentration of IL-10 detected in patients with severe immunodeficiency (IL-10 levels in group II was 5 times higher, p , 0.05), which may indirectly indicate a more active involvement of IL-10 during ...
Rabbit anti Human Interleukin-10 antibody recognizes human IL-10 (Interleukin-10), an 18.5kDa immunosuppressive cytokine originally known
... play a key role in protecting from the pathogenesis of Leishmania infection, and their balance and dynamic changes ..
IL-25). A member of the IL-17 family of immunoregulatory cytokines (IL-17E; SF20, a homodimer of 177 aa subunits), produced by Th2 cells. It has a role in allergic inflammation by up-regulating IgG and IgE production, eosinophil levels, and inflammatory responses, through induction of IL-4, IL-5, and IL-13. ...
Determination of IL-1β, IL-6, TNF-α, MIP-1α, IL-10, TGF-β1 and FGFb levels in the cell-free supernatant obtained from monocytes from healthy subjects (CG, n
For humans it is crucial to control lipid homeostasis to avoid development of metabolic disorders. Dyslipidemia is a considerable risk factor for development of cardiovascular and liver diseases, such as non-alcoholic fatty liver disease (NAFLD). Infection and inflammation induce the acute phase response (APR), leading to multiple alternations in lipid and lipoprotein metabolism, mediated by changed cytokine production, especially tumor necrosis factor (TNF)-a, interleukin (IL)-1 and IL-6. Another cytokine IL-10 has anti-atheromatous and anti-inflammatory effects, and it has been postulated that IL-10 has gene therapeutic potential. However, the effect of IL-10 on liver and its metabolic functions are still unclear. In the present study, we investigated whether IL-10 could modulate lipid homeostasis in TNF-a- and IL-6-stimulated hepatocytes. We demonstrated that IL-6 increased expression of genes involved in hepatic fatty acid (FA) synthesis [SREBP1a, FAS], FA oxidation [PPARa, CPT1a, CPT2], FA ...
In this study, we have demonstrated that the pan-HDI LAQ824, by inhibiting IL-10 and increasing the expression of B7.2 and the production of several proinflammatory mediators, induced inflammatory macrophages that effectively activate Ag-specific CD4+ T cells and restore the responsiveness of anergic T cells.. Among the above changes, the most striking effect of LAQ824 was its ability to inhibit the production of the immunosuppressive cytokine IL-10. Such an effect was also displayed by other members of the hydroxamic acid family like LBH589, TSA, and SAHA, but not by the more specific HDI MS-275, which mainly target class I HDACs. The central role of IL-10 in the establishment and maintenance of T cell anergy (34, 35, 42-44) prompted us to further investigate the underlying mechanism(s) by which these particular HDIs inhibit IL-10 production in macrophages.. The dynamic production of pro- and anti-inflammatory mediators at the site of Ag encounter has been shown to shape the initiation, ...
In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, including prostaglandin E₂ (PGE₂). PGE₂ has key roles in many early inflammatory events, such as the changes of vascular function that promote or facilitate leukocyte recruitment to sites of inflammation. Depending on context, it also exerts many important anti-inflammatory effects, for example increasing the expression of the anti-inflammatory cytokine interleukin 10 (IL-10), and decreasing that of the pro-inflammatory cytokine tumor necrosis factor (TNF). The tight control of both biosynthesis of, and cellular responses to, PGE₂ are critical for the precise orchestration of the initiation and resolution of inflammatory responses. Here we describe evidence of a negative feedback loop, in which PGE₂ augments the expression of dual specificity phosphatase 1, ...
B cells like the one pictured here produce tiny packages of an anti-inflammatory molecule that could be used to treat autoimmune diseases, according to new IRP research.
IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4(+) T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4 blockade inhibited while addition of exogenous IL-4 to Th1 cultures enhanced IL-10 production. In the in vivo setting of peptide immunotherapy leading to a chronically stimulated Th1 phenotype, lack of IL-4Rα inhibited the induction of IL-10. Exploring the interplay of Th1 and Th2 cells through co-culture, Th2-derived IL-4 promoted IL-10 expression by Th1 cultures, reducing their pathogenicity in vivo. Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T-bet(+) cells in these cultures. Addition of IL-4 also reduced the encephalitogenic capacity of Th1 ...
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Dr. Center is Boston Universitys Associate Provost for Translational Research and the Director of the Clinical and Translational Research Institute funded by the NIH. As a result he directs Boston Universitys efforts to facilitate translational research in all venues and leads a major effort in identifying new areas of development.. His own laboratory is interested in two major themes which revolve around roles for Interleukin-16, co-discovered with Bill Cruikshank in 1982. The first theme relates to the functions of IL-16 as a immunomodulatory cytokine. Over the past several years, in collaboration with Bill Cruikshank, he has studied the role of IL-16 in recruitment and development of Regulatory T cells and demonstrated that it plays a key role in tolerance to airborne allergens. Utilizing transgenic knockout and overexpressing mice his laboratory is involved in demonstrating the patterns of CD4+ T cell trafficking through lymph nodes and lung parenchymal in normal and immunologically ...
Walter and Eliza Hall Institute scientists have developed a new drug-like molecule that can halt inflammation and has shown promise in preventing the progression of multiple sclerosis (MS).
During the first treatment pro-inflammatory cytokines IL-1b, TNF-a, IL-6 and IL-8 levels decreased, anti-inflammatory cytokines IL-4, IL-13 were constant within the normal range, IL-10 and MCP-1 levels decreased 10-fold to about normal ...
In this report we describe the generation of mice deficient in IL-13Rα2 to define the role of this receptor chain in IL-13 responses. IL-13Rα2 may act to modulate the effects of IL-13 in vivo in various ways. IL-13Rα2 could enhance IL-13 activities by increasing the strength of IL-13 signaling or attenuate IL-13 effects by negative signaling or simply as a molecular decoy. Attenuating roles of IL-13Rα2 could explain the lack of evidence for IL-13 effects on T cells or an enhancing role could explain the effect of IL-13 effect on airways hyperreactivity and eosinophil survival distinct from IL-4.. Interestingly, we find that the absence of IL-13Rα2 correlates with nearly complete loss of serum IL-13 and an increase in tissue IL-13 in IL-13Rα2−/− mice. The lack of serum IL-13 cannot be explained by a lack of IL-13 production in IL-13Rα2−/− mice as IL-13 is present in tissues of IL-13Rα2−/− and is produced by activated IL-13Rα2−/− immune cells. Serum IL-13Rα2 may act as a ...
PAN Czytelnia Czasopism, The inflammatory reaction and the expression of pro- and anti-inflammatory cytokines to a novel polyester-polyurethane aortic prosthesis evaluated in dog sat 6 and 12 months post-implantation - Polish Journal of Veterinary Sciences
Invitrogen™ eBioscience™ Mouse IL-6 ELISA Ready-SET-Go!™ Kit 2 x 96 tests Invitrogen™ eBioscience™ Mouse IL-6 ELISA...
The immature B cells that successfully make it through this process (only about 10%) enter into the bloodstream and migrate to the spleen. The immature B cells have both IgM and IgG (BCRs) expressed on their surface at this point and once they enter into the spleen are called transitional type 1 (T1) B cells. In the spleen B cells, T cells, and follicular dendritic cells, form what is known as a primary follicle or sometimes the white pulp (See Figure 2). The T1 B cells are located outside of the follicle (extrafollicular) in an area known as the red pulp (as this is where all of the red cells are flowing through the spleen). At this point, the T1 B cells are exposed to more self cells and circulating proteins and if they respond strongly it would indicate autoreactivity and the cells are typically induced to become T3 B cells, which are anergic (which means they become non-responsive to antigen), and will likely die off.. If the T1 B cells survive through this they can then migrate into the ...
有多种机制认为病毒感染与过敏性炎症相互作用,从而导致下呼吸道功能障碍、喘息和哮喘。首先,潜在的过敏性炎症可以直接增强气道对鼻病毒感染的反应性。此外,病毒感染可损害气道上皮的屏障功能,导致气道壁对气传过敏原的吸收增加和炎症反应增强,而潜在的过敏性炎症也可能导致病毒复制增强。值得注意的是,鼻病毒感染和变应原均可促进气道上皮细胞产生IL-33, IL-33是最近发现的一种先天细胞因子,可促进2型气道炎症和重塑。据报道,这种类固醇耐药途径在难以控制哮喘的儿童中上调。有趣的是,IL-33多聚物与中晚期发作的喘息有关,而中晚期发作的喘息与早期生活中的过敏反应密切相关。 另一种先天上皮细胞因子IL-25也由鼻病毒诱导,在过敏患者鼻病毒感染的情况下,IL-25可能加重过敏性气道炎症 ...
Инфламмасома - важный компонент нативного иммунитета. Она представляет собой макромолекулярный комплекс, включающий сенсорные элементы, адапторные белки и зимоген каспазы-1. Под действием продуктов распада тканей и патогенных микроорганизмов инфламмасома активируется и превращает про-IL-1b и про-IL-18 в активные интерлейкины. Активация инфламмасом отмечена при многих воспалительных заболеваниях и служит мишенью для терапевтических воздействий. В настоящем обзоре обсуждается вклад инфламмасом в патогенез социально-значимых заболеваний ...
Fundamental knowledge about the development of the spinal cord is essential to devise approaches for functional spinal cord repair, comprising neuroprotection after injury, replacement of lost neurons and glia, and axonal regeneration.. Pablo Villoslada (IDIBAPS, Barcelona, Spain) presented regenerative therapies for spinal cord injury and multiple sclerosis (MS) in which axonal damage, demyelination and clinical signs are closely correlated, including MESEMS (https://clinicaltrials.gov/ct2/show/NCT01854957), which is currently recruiting participants for a trial of neuroprotection by mesenchymal stem cell (MSC) administration. Similarly, Dearbhaile Dooley (Hendrix lab, Hasselt University, Belgium) has transplanted MSCs, virally transduced to express the TH2 anti-inflammatory cytokine interleukin 13, rostral to a spinal lesion site in the mouse. Dooley observed a reduction in lesion size and demyelination, potentially mediated by a decrease in the number of microglia/macrophages and increased ...
Inflammation is a beneficial mechanism that is usually triggered by injury or infection and is designed to return the body to homeostasis. However, uncontrolled or sustained inflammation can be deleterious and has been shown to be involved in the etiology of several diseases, including inflammatory bowel disorder and asthma. Therefore, effective anti-inflammatory signaling is important in the maintenance of homeostasis in the body. However, the inter-play between pro- and anti-inflammatory signaling is not fully understood. In the present study, we develop a mathematical model to describe integrated pro- and anti-inflammatory signaling in macrophages. The model incorporates the feedback effects of de novo synthesized pro-inflammatory (tumor necrosis factor alpha; TNF-a) and anti-inflammatory (interleukin-10; IL-10) cytokines on the activation of the transcription factor nuclear factor kappaB (NF-kB) under continuous lipopolysaccharide (LPS) stimulation (mimicking bacterial infection). In the ...
Fingerprint Dive into the research topics of Anti-inflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: Hypertension blunts the response. Together they form a unique fingerprint. ...
Acute psychosocial stress stimulates transient increases in circulating pro-inflammatory plasma cytokines, but little is known about stress effects on anti-inflammatory cytokines or underlying mechanisms. We investigated the stress kinetics and interrelations of pro- and anti-inflammatory measures on the transcriptional and protein level.,br /,,br /,Forty-five healthy men were randomly assigned to either a stress or control group. While the stress group underwent an acute psychosocial stress task, the second group participated in a non-stress control condition. We repeatedly measured before and up to 120 min after stress DNA binding activity of the pro-inflammatory transcription factor NF-κB (NF-κB-BA) in peripheral blood mononuclear cells, whole-blood mRNA levels of NF-κB, its inhibitor IκBα, and of the pro-inflammatory cytokines interleukin (IL)-1ß and IL-6, and the anti-inflammatory cytokine IL-10. We also repeatedly measured plasma levels of IL-1ß, IL-6, and IL-10.,br /,,br /,Compared ...
Atherosclerosis is recognized as a complex multifactorial process and a chronic inflammatory disease contributed to severe cardiovascular event, which can be triggered by various stimuli [18]. Among them, TGF-β as a represented immunomodulatory cytokine is of particular interest to cardiovascular biologists through regulation of multiple cell types involved in blood vessel wall [6]. Notably, accumulative evidences have demonstrated that TGF-β exerts an important role in atherogenesis [19,20], whereas the studies of TGF-β receptor modulation account for the effect remains unclear. Members of the TGF-β family of cytokines signal exert the functional regulation of the pathological process via serine/threonine kinase transmembrane type I and type II receptors at the cell membrane [6]. Binding TGF-β to the receptor complex triggers activation of type I receptor terms as ALK, which can initiate downstream signaling including Smad phosphorylation, MAPK and PI3K-Akt signaling, while all three ...
Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer. ...
Type 2 diabetes is associated with an increased risk of cardiovascular disease. A series of metabolic risk factors have been proposed to account for the accelerated development of atherosclerosis in patients with this disease. In addition, in recent years, chronic inflammation has received increasing attention as an important pathophysiological mechanism in both type 2 diabetes and atherosclerosis. Therefore, genetic variability in factors involved in the regulation of inflammation may have a particular impact on the progression of atherosclerosis in patients with type 2 diabetes.. The interleukin-1 (IL-1) pathway is a central mediator of inflammatory reactions. Increased activation of the IL-1 proinflammatory axis has been reported in diabetes, and IL-1 is also involved in atherogenesis by a multitude of mechanisms. The IL-1 gene cluster contains the genes encoding the proinflammatory cytokines IL-1α and -1β and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra). Among the ...
NEX232 Interleukin-1 (IL-1) refers to a group of three polypeptides (interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra)), that play a central role in the regulation of immune and inflammatory responses.. IL-1β is a pro-inflammatory cytokine involved in immune defense against infection. ...
We hear constant chatter from the regulatory types about the dangers of raw milk and the health hazards of consuming it. But they seem to be strangely uninterested in examining the health risks of consuming conventionally produced and processed milk products, not to mention many other processed foods. The L.A. Times article excerpted below gives…
Interleukin-6 (IL-6), 2 µg. Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages.
Interleukin-6 (IL-6), 1 mg. Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages.
... An international group of scientists have now found that the cytokine IL-23 is heavily involved in autoimmune and inflammatory diseases, thereby opening the door to new therapies targeting the molecule.
Interferon-gamma is a regulatory cytokine secreted by activated Th1 Cells which promotes phagocytosis of internalized bacteria by Macrophages. This cytokine is also thought to play an important role in the development of Giant Cells and Granulomas ...
CCL4, CCL20, IFN-γ, IL-2, IL-4, IL-10, IL-16, IL-17A, IL-17F, IL-18, MIF, TNSF15, IL-1β, IL-1R, IL-6, IL-7, IL-7R, IL-8, IL-10R, IL-12p35, IL-12p40, IL-3, IL-15, IL-16, IL-21, IL-21R, IL-22, IL-17D, LITAF, NK-lysin, CD25, CD80, CD83, CD86, IFN-α, IFN-r, TGFB4, B-defensin8 ...
人IL-2 ELISA试剂盒(Interleukin-2) ELISA试剂盒datasheet (ab100566).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
人IL-17 ELISA试剂盒(Interleukin-17) ELISA试剂盒datasheet (ab100556).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽,使用效果保证,中国70%以上现货。
IL-12/IL-23 p40, Functional Grade, clone: C8.6, eBioscience™ 500μg; Functional Grade IL-12/IL-23 p40, Functional Grade, clone: C8.6, eBioscience™...
Serological cytokine expression for IL-1β over the time course.IL-1β levels were detected at all the allocated time points with a significant difference betwe
Receptors, Interleukin-4, Type I information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
产品名称:HumanIL-5ELISAReady-SET-Go规格:10plates货号:88-7056-88厂商:eBioscience产品介绍:Alsoknownas:Interleukin-5ReactivityHumanSensitivity4pg/mLStandardCurveRange4-500pg/mLComponentsCaptureAntibody.Pre-titrated,pu
In the past decade, the suppressive effects, mainly through the secretion of IL-10, of regulatory B cells on inflammatory responses have been reported in a variety of immune disorders (33-36). Additionally, immune regulation through the interaction of immune cells with the intrinsic phenotype of regulatory B cells (e.g., CD1dhiCD5+, T2-MZP, Tim-1+, and CD9+) were demonstrated in various diseases, and it plays a critical role in autoimmune diseases (37). In recent studies, functional studies in cancer diseases are emerging (38-40). In particular, the change of the distribution of regulatory B cells in cancer tissue is considered to one of important indicators (8-10). Emerging evidence suggests that regulatory B cells suppress effector immune cells including IFN-γ-producing cytotoxicity cells in various cancer diseases through the secretion of IL-10 (11). Although regulatory B cells have to play the suppressive role on the effector function of T cells in autoimmune diseases to cure diseases (41), ...