Plasmid pcDNA3-GFP-p48 from Dr. Steven Johnsons lab contains the insert Interferon-Stimulated Gene Factor 3. This plasmid is available through Addgene.

The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat1 is expressed as two variants of 84 and 91 kDa. Stat1 proteins contain SH2 and SH3 domains, and are components of the interferon-stimulated gene factor 3 (ISGF3) complex. This complex is the primary transcription

You snor earlier when youre on your back. Sleeping on your belly is stressful for your neck, therefore, sleep on your side. People snor on their backs because the muscles of the soft palate, the hide and the tongue relax, block the airway. An anti-snap bracket can then help keep the tongue in the same position, so that it does not roll backwards and blocks the airways.. read more ...

Alpha interferon stimulates transcription by converting the positive transcriptional regulator ISGF3 from a latent to an active form. This receptor-mediated event occurs in the cytoplasm, with subsequent translocation of the activated factor to the nucleus. ISGF3 has two components, termed ISGF3 alpha and ISGF3 gamma. ISGF3 gamma serves as the DNA recognition subunit, while ISGF3 alpha, which appears to consist of three polypeptides, is a target for alpha interferon signaling and serves as a regulatory component whose activation is required to form ISGF3. ISGF3 gamma DNA-binding activity was identified as a 48-kDa polypeptide, and partial amino acid sequence has allowed isolation of cDNA clones. ISGF3 gamma translated in vitro from recombinant clones bound DNA with a specificity indistinguishable from that of ISGF3 gamma purified from HeLa cells. Sequencing of ISGF3 gamma cDNA clones revealed significant similarity to the interferon regulatory factor (IRF) family of DNA binding proteins in the ...

TY - JOUR. T1 - IFN - g priming up - regulates IFN - stimulated gener factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type IIFNs. AU - Wong, Lee Hwa. AU - Hatzinisiriou, Irene. AU - Devenish, Rodney J. AU - Ralph, Steve J. PY - 1998. Y1 - 1998. M3 - Article. SP - 5475. EP - 5484. JO - Journal of Immunology. JF - Journal of Immunology. SN - 0022-1767. ER - ...

Mouse IFN alpha A Recombinant Protein, Invitrogen™ >1x10^5 UN; Unlabeled Mouse IFN alpha A Recombinant Protein, Invitrogen™ Proteins I

Kit Component:- KN308431G1, Irf9 gRNA vector 1 in pCas-Guide vector- KN308431G2, Irf9 gRNA vector 2 in pCas-Guide vector- KN308431D, donor vector…