Ion channels regulate cell proliferation, differentiation, and migration in normal and neoplastic cells through cell-cell and cell-extracellular matrix (ECM) transmembrane receptors called integrins. K+ flux through the human ether-à-go-go-related gene 1 (hERG1) channel shapes action potential firing in excitable cells such as cardiomyocytes. Its abundance is often aberrantly high in tumors, where it modulates integrin-mediated signaling. We found that hERG1 interacted with the β1 integrin subunit at the plasma membrane of human cancer cells. This interaction was not detected in cardiomyocytes because of the presence of the hERG1 auxiliary subunit KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1), which blocked the β1 integrin-hERG1 interaction. Although open hERG1 channels did not interact as strongly with β1 integrins as did closed channels, current flow through hERG1 channels was necessary to activate the integrin-dependent phosphorylation of Tyr397 in focal ...
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CD49e (Integrin alpha 5), clone: eBioSAM-1 (SAM-1, SAM1), eBioscience™ 100μg; Unconjugated CD49e (Integrin alpha 5), clone: eBioSAM-1 (SAM-1, SAM1),...
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integrin alpha7: expression is used as a marker for early stages of myogenesis; has 3 isoforms alpha7 A, B, & C; amino acid sequence has been determined
购买Integrin alpha 6小鼠单克隆抗体[450-30A](ab30497),Integrin alpha 6抗体经Flow Cyt验证,可与人样本反应。产品出库一年都在质保范围内。中国现货速达。
Plasmid Alpha 5 integrin-GFP from Dr. Rick Horwitzs lab contains the insert alpha 5 integrin and is published in J Cell Biol. 2001 Jun 25. 153(7):1427-40. This plasmid is available through Addgene.
Integrin alpha M (ITGAM) Antibody is a Rabbit Polyclonal antibody against Integrin alpha M (ITGAM). Integrin alpha M (ITGAM), also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of mo
AS tumors are vascularized, but do not induce DIC. AS-Tspan8 tumors are highly vascularized and induce DIC. Abundantly Tspan8-expressing ASML tumors are poorly vascularized (3, 28). These three tumors strongly express CD9, CD81, and CD151 (3, 4, 33). Coimmunoprecipitation of Tspan8 with integrins revealed that, in ASML cells, Tspan8 interacts with CD104 and overexpression of CD104 in AS-Tspan8 cells prevents angiogenesis (34). These findings indicated that selective integrin associations with Tspan8 might be decisive for Tspan8 exosome-induced angiogenesis.. Indeed, comparing Tspan8 associations in AS-Tspan8 exosomes and CD9 associations in AS and AS-Tspan8 exosomes revealed that CD49d associates with CD9, CD151, and Tspan8 only in AS-Tspan8 exosomes. In contrast, CD49c associates with CD9 in both AS and AS-Tspan8 exosomes. This implies that Tspan8 selectively recruits CD49d into exosomes via yet unknown mechanisms.. The presence of Tspan8-associated CD49d is utmost important for AS-Tspan8 ...
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CHO-Anti-Human Integrin alpha 2b beta 3 MAb stable cell line is clonally-derived from a CHO cell line, which has been transfected with an anti-human Integrin alpha 2b beta 3 MAb gene to allow expression of the MAb. It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
CHO-Anti-Human Integrin alpha 4 beta 7 scFv stable cell line is clonally-derived from a CHO cell line, which has been transfected with an anti-human Integrin alpha 4 beta 7 scFv gene to allow expression of the scFv. It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
Integrin alpha 3小鼠单克隆抗体[J143](ab11767)可与人样本反应并经IHC, ICC实验严格验证,被5篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Epithelio-mesenchymal interactions during kidney organogenesis are disrupted in integrin alpha8 beta1-deficient mice. However, the known ligands for integrin alpha8 beta1-fibronectin, vitronectin, and tenascin-C-are not appropriately localized to mediate all alpha8 beta1 functions in the kidney. Using a method of general utility for determining the distribution of unknown integrin ligands in situ and biochemical characterization of these ligands, we identified osteopontin (OPN) as a ligand for alpha8 beta1. We have coexpressed the extracellular domains of the mouse alpha8 and beta1 integrin subunits as a soluble heterodimer with one subunit fused to alkaline phosphatase (AP) and have used the alpha8 beta1-AP chimera as a histochemical reagent on sections of mouse embryos. Ligand localization with alpha8 beta1-AP in developing bone and kidney was observed to be overlapping with the distribution of OPN. In "far Western" blots of mouse embryonic protein extracts, bands were detected with sizes ...
CD103 (Integrin alpha E) Mouse anti-Human, APC, Clone: B-Ly7, eBioscience™ 100 tests; APC CD103 (Integrin alpha E) Mouse anti-Human, APC, Clone: B-Ly7,...
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Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an ...
IMG SRC="/math/agr.gif" ALT="{alpha}" BORDER="0",,SUB,E,/SUB,ß,SUB,7,/SUB, integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and ...
Buy our Recombinant Human Integrin alpha 1 protein. Ab112310 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA, SDS-PAGE. Abcam…
View mouse Itga7 Chr10:128933818-128958282 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
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pep: chromosome:VEGA66:11:102453297:102469883:-1 gene:OTTMUSG00000002857 transcript:OTTMUST00000005811 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Itga2b description:integrin alpha 2b ...
The basal lamina of muscle fibers plays a crucial role in the development and function of skeletal muscle. An important laminin receptor in muscle is integrin alpha7beta1D. Integrin beta1 is expressed throughout the body, while integrin alpha7 is more muscle-specific. To address the role of integrin …
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Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[5] ...
Looking for online definition of Laminin-4 subunit alpha in the Medical Dictionary? Laminin-4 subunit alpha explanation free. What is Laminin-4 subunit alpha? Meaning of Laminin-4 subunit alpha medical term. What does Laminin-4 subunit alpha mean?
Integrin alpha 5 antibody [HM alpha 5] (integrin alpha 5 (fibronectin receptor alpha)) for FACS, IP, WB. Anti-Integrin alpha 5 mAb (GTX41950) is tested in Mouse, Rat samples. 100% Ab-Assurance.
Colocalization of TGFβ1, αVβ6 integrin and the cytoskeleton. Panc-1 cells were stimulated with mature TGFβ1 and stained using anti TGFβ1 (labeled with goat
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