The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulinlike growth factor-binding proteins) and insulin are essential to muscle metabolism and most aspects of male and female reproduction. Insulin-like growth factor and insulin play important roles in the regulation of cell growth, differentiation and the maintenance of cell differentiation in mammals. In order to better understand the local factors that regulate equine physiology, such as muscle metabolism and reproduction (e.g., germ cell development and fertilisation), real-time reverse transcription polymerase chain reaction assays for quantification of equine insulin-like growth factor 1 receptor and insulin receptor messenger ribonucleic acid were developed. The assays were sensitive: 192 copies/μL and 891 copies/μL for insulin-like growth factor 1 receptor, messenger ribonucleic acid and insulin ...
Increasing of body weight has been one of the important economic factors in the poultry industry. Insulin-like growth factor (IGF)-I is a polypeptide that serves to regulate muscle development and body growth. Moreover, IGF-I is related to feed efficiency. However, there are few studies regarding the regulatory roles of chicken IGF-I/-II compared with that of mammals. Especially, the Korean Native Ogol Chicken (KNOC) has a lean body growth and its body weight is generally lighter than the broiler chicken. Therefore, this study was conducted to investigate associations among serum IGF-I/-II concentration, feed efficiency, and body growth in KNOC. The body weight and feed intake of KNOC were recorded from 20 to 36 weeks at 2 weeks intervals, and blood was taken every 2 weeks. Serum IGF-I/-II were measured by RIA. Chickens were divided into two groups, high and low serum IGF-I concentration. Generally, feed efficiency and growth performance (body weight and weight gain) in the high serum IGF-I ...
TY - JOUR. T1 - Effects of aromatase complex selective inhibition on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 circulating levels in breast cancer. AU - Ferrari, Leonardo. AU - Bajetta, Emilio. AU - Seregni, Ettore. AU - Martinetti, Antonia. AU - Zilembo, Nicoletta. AU - Noberasco, Cristina. AU - Buzzoni, Roberto. AU - Botti, Carlo. AU - Massaron, Simonetta. AU - Bichisao, Ettore. AU - Celio, Luigi. AU - Bombardieri, Emilio. PY - 1997. Y1 - 1997. N2 - The aim of our study is to evaluate insulin-like growth factor (IGF) and IGF binding protein (IGFBP)-3 circulating levels in postmenopausal women treated with type I aromatase inhibitor formestane for breast cancer. Sixty- three patients at their first relapse entered the trial and were randomly given formestane at 250 mg or 500 mg i.m. fortnightly. Effects of the endocrine treatment on IGF-1 and IGFBP-3 were measured before and during therapy at scheduled times. IGF-1 and IGFBP-3 seems to slightly increase in ...
TY - JOUR. T1 - Effect of Ethanol on Insulin‐Like Growth Factor‐II Release from Fetal Organs. AU - Mauceri, Helena J.. AU - Lee, Wei‐Hua ‐H. AU - Conway, Sonya. PY - 1994/2. Y1 - 1994/2. N2 - This study examines the effect of ethanol (ETOH) exposure and nutrient restriction on the release of insulin‐like growth factor (IGF)‐II from 18‐ and 20‐day explanted fetal organs. Fetuses were exposed to ETOH (E) in utero by feeding dams a 36% (calories derived from ETOH: 6.6% v/v) ETOH liquid diet. Control fetuses were offsprings of dams either pair‐fed (P) a control liquid diet or ad libitum (A) fed a standard pelleted lab chow. Brain, heart, kidney, liver, lung, muscle, and placenta of fetuses from the same litter were pooled and explanted, and IGF‐II concentration in explanted media was analyzed by radioimmunoassay. Maternal and fetal weights were determined during pregnancy and at sacrifice, respectively, to evaluate the influence of ETOH on growth. Both maternal and fetal weights ...
Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on parity-associated protection against mammary cancer. Three groups of rats were evaluated in the present study: IGF-I-treated parous rats; parous rats that did not receive IGF-I treatment; and age-matched virgin animals, which also did not receive IGF-I treatment. Approximately 60 days after N-methyl-N-nitrosourea injection, IGF-I treatment was discontinued and all of the animal groups were implanted with a silastic capsule containing 17β-estradiol and progesterone. The 17β-estradiol plus progesterone treatment continued for 135 days, after which the animals were killed. IGF-I treatment of parous rats increased mammary tumor incidence to 83%, as compared with 16% in parous rats treated with 17β-estradiol plus progesterone
Click to launch & play an online audio visual presentation by Prof. Derek LeRoith on The growth hormone/insulin-like growth factor-1 axis in health and disease, part of a collection of online lectures.
Zhou, X.; Hintz, R. L.; LIN, Ting Kwong; How, W. H. K.; Aw, T C; and Lee, K O. Serum Insulin-Like Growth Factor-I (Igf-I) and Dehydroepiandrosterone-Sulphate (Dhea-S) in a Community Dwelling Elderly Population. (1997). Endocrinology and Metabolism. 4, (5), 345-351. Research Collection School Of Economics ...
Pre- and postnatal growth failure can be caused by mutations in the IGF1 (insulin-like growth factor 1) or IGF1R (insulin-like growth factor 1 receptor) genes. Autosomal recessive mutations in IGF1 cause insulin-like growth factor I deficiency (MIM 608747), which is characterized by microcephaly, intellectual disability, and deafness in addition to the growth failure. Autosomal dominant mutations in IGF1R cause insulin-like growth factor I, resistance to (MIM 270450). It is associated with partial IGF1 resistance, pre- and postnatal growth failure, microcephaly, and in some cases modest intellectual disability. Autosomal recessive IGF1R mutations have been found in a few patients. This results in a more severe growth delay and additional developmental abnormalities.. Read less ...
Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment ...
Background Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a...
Problem statement: The IGFs play an important role in regulating somatic growth according to nutritional conditions. Polymorphisms of IGF gene are reported to be significantly associated with many traits. Approach: In these study 142 samples of DNA from Zel sheep were used for detecting the polymorphisms of promoter region of the Insulin-like Growth Factor-1 (IGF-1) gene. Therefore DNA extracted from blood using Salting-out procedure. Results: Primers were supplied for amplifying the specific segment. Polymerase Chain Reaction (PCR) accomplished after finding the best condition to do the reaction. The specific segment amplified well. SSCP and RFLP markers were used for detecting the polymorphisms of the segment. For SSCP analysis PCR-product was denatured and dilution was loaded onto a 12% polyacrylamide gel. RFLP analysis was performed by incubating of PCR product by HaeII restriction enzyme at 37°C for 4 h. Gels were visualized using a 3.5% agarose gel that contained ethidium bromide. The
The associations between serum concentrations of insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins (IGFBP)-3 and risk of breast cancer were investigated in a nested case-control study involving 117 cases (70 premenopausal and 47 postmenopausal at blood collection) and 350 matched controls within a cohort of women from the island of Guernsey, UK. Women using exogenous hormones at the time of blood collection were excluded. Premenopausal women in the top vs bottom third of serum IGF-I concentration had a nonsignificantly increased risk for breast cancer after adjustment for IGFBP-3 (odds ratio (OR) 1.71; 95% confidence interval (CI): 0.74-3.95; test for linear trend, P=0.21). Serum IGFBP-3 was associated with a reduction in risk in premenopausal women after adjustment for IGF-I (top third vs the bottom third: OR 0.49; 95% CI: 0.21-1.12, P for trend=0.07). Neither IGF-I nor IGFBP-3 was associated with risk in postmenopausal women and serum IGF-II concentration was not associated with
In vitro studies have shown that insulin-like growth factor (IGF) is a mitogen for breast cancer cells. However, the associations of plasma IGF-I with tumor histopathology in high-risk groups need fur
Popular Products of Human Insulin Like Growth Factor Binding Protein 1 (IGFBP1) ELISA Kit, guaranteed quality elisa, IBP1 AFBP IGF-BP25 PP12 by Human ELISA Kit - Wuxi Donglin Sci & Tech Development Co.,Ltd. from China.
BACKGROUND: Some studies suggest that elevated serum insulin-like growth factor (IGF)-I concentrations are associated with an increased risk of prostate cancer and, in particular, with an increased risk of advanced-stage prostate cancer. METHODS: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. This study includes 630 incident prostate cancer cases and 630 matched control subjects. Odds ratios and their 95% confidence intervals (95% CI) were calculated for prostate cancer risk associated with increasing IGF-I and IGFBP-3 concentrations using conditional logistic regression. RESULTS: The risk of total prostate cancer in the highest versus the lowest third of serum peptide concentration was 1.35 (95% CI, 0.99-1.82; Ptrend = 0.08) for IGF-I, 1.39 (95% CI, 1.02-1.89; Ptrend = 0.12) for the IGF-I residuals after
Background: Some studies suggest that elevated serum insulin-like growth factor (IGF)-I concentrations are associated with an increased risk of prostate cancer and, in particular, with an increased risk of advanced-stage prostate cancer. Methods: We analyzed the association between prediagnostic serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. This study includes 630 incident prostate cancer cases and 630 matched control subjects. Odds ratios and their 95% confidence intervals (95% CI) were calculated for prostate cancer risk associated with increasing IGF-I and IGFBP-3 concentrations using conditional logistic regression. Results: The risk of total prostate cancer in the highest versus the lowest third of serum peptide concentration was 1.35 (95% CI, 0.99-1.82; P trend = 0.08) for IGF-I, 1.39 (95% CI, 1.02-1.89; P trend = 0.12) for the IGF-I residuals after
Our finding that a relatively high concentration of IGF-I is associated with an increased risk for prostate cancer is consistent with results from a pooled reanalysis of individual participant data from 12 prospective studies (which includes phase I of this study; ref. 2). This association is evident for both localized and advanced disease and exists over the short and long term. While it is likely that some men with subclinical disease at recruitment were included in our study [because of the long lag time between disease onset and clinical symptoms (6)], the positive association observed among men diagnosed with advanced stage disease (for whom nearly 65% were diagnosed more than 4 years after recruitment) and among men diagnosed more than 7 years after blood collection, supports the hypothesis that IGF-I is associated with prostate cancer many years before diagnosis.. IGF-I concentration was also associated with an increased risk of localized prostate cancer. This finding contrasts with those ...
TY - JOUR. T1 - Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription. AU - Chia, Dennis J.. AU - Ono, Mitsuru. AU - Woelfle, Joachim. AU - Schlesinger-Massart, Mylynda. AU - Jiang, Honglin. AU - Rotwein, Peter. PY - 2006/2/10. Y1 - 2006/2/10. N2 - A key agent in the anabolic actions of growth hormone (GH) is insulin-like growth factor-I (IGF-I), a 70-amino acid secreted protein with direct effects on somatic growth and tissue maintenance and repair. GH rapidly and potently stimulates IGF-I gene transcription by mechanisms independent of new protein synthesis, and recent studies have linked the transcription factor Stat5b to a regulatory network connecting the activated GH receptor on the cell membrane to the IGF-I gene in the nucleus. Here we analyze two distinct conserved GH response elements in the rat IGF-I locus that contain paired Stat5b sites. Each response element binds Stat5b in vivo in a GH-dependent way, as assessed by ...
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF- I and IGF-II. IGF-BP-6 plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.Human recombinant IGF-BP-6 produced in E. coli is a single, non-glycosylated polypeptide chain containing the amino acids 148-240 and having a molecular mass of 20 kDa including a 4 kDa His tag. It is purified by using proprietary chromatographic techniques ...
Growth failure and GH/IgF-1 deficiency has been described in patients diagnosed with Ataxia telangiectasia (AT) [Boder et al.,1958]. This condition is a fatal inherited disease caused by a mutation of the ATM gene on chromosome 11 leading to chromosomal instability, immunodeficiency, cancer susceptibility and and endocrinological abnormalities. In this regard, several groups demonstrated a cross-linking of ATM with growth factor pathways. Participation of the ATM protein in insulin signaling through phosphorylation of eIF-4E-binding protein 1 has been postulated [Yang et al.,2000]. Peretz et al.[2001] described that expression of the insulin-like growth factor-I receptor is (IGF-I R) ATM dependent in a pathway regulating radiation response. In addition, Shahrabani-Gargir et al.[2004] found that the ATM gene controls IGF-I R gene expression in a DNA damage response pathway. Suzuki et al.[2004] described that IGF-I phosphorylates AMPK-alpha, a key regulator of cholesterol and fatty acid synthesis, ...
TY - JOUR. T1 - Human growth disorders. T2 - Molecular genetics of the growth hormone- insulin-like growth factor I axis. AU - Rotwein, P.. PY - 1999/1/1. Y1 - 1999/1/1. N2 - The critical role of the growth hormone-insulin-like growth factor I axis in controlling somatic growth in humans and other vertebrate species has been known for many years. Through molecular cloning and other related techniques many of the components of this axis have been characterized, with the most recent additions being key transcription factors required for pituitary development and for pituitary-specific gene expression. Several of these genes have been shown to be mutated in familial and sporadic human growth deficiency syndromes, thereby validating the central roles of the encoded proteins in the endocrine pathways regulating somatic growth. The purpose of this review is to highlight these recent advances from the perspective of the molecular genetics of human growth disorders.. AB - The critical role of the growth ...
The NHS was established in 1976, when 121,700 female registered nurses (age, 30-55 years) returned a completed mailed questionnaire. Since that time, biennial mailed questionnaires have been sent to update exposure histories and ascertain changes in medical and health status. Information collected includes height, weight, reproductive history, history of benign breast disease, alcohol intake, levels of physical activity, first-degree family history of breast cancer, menopausal status, and postmenopausal hormone use as well as any diagnosis of cancer or another illness. In 1989-1990, blood samples were collected from 32,826 participants in the NHS. Blood collection and sample storage methods have been detailed in a previous publication (8) .. In the study reported here, we compared the percentage of the total breast area appearing dense on mammography with the plasma concentrations of IGF-I and IGFBP-3 among selected NHS participants who had served as controls in the previous study of plasma ...
Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to unhealthy diet. Early‐life diet also associates with DNA methylation of the insulin‐like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high‐fat and ‐sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early‐onset persistent (EOP) versus low CP youth. Read the Commentary on this article at doi ...
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Circulating total testosterone and insulin like growth factor 1 as determinants of haemoglobin level in men with chronic heart failure Conference Paper ...
OsrIGF-1 is expressed as fusion protein with HSA, which increases its solubility and lifetime. OsrIGF-1 presents a molecular weight about 74.5kD, and has a much higher stability compared to IGF-1.
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (Insulin-like growth factor 1 (IGF-1) and Insulin-like growth factor 2 (IGF-2)), a family of six high-affinity IGF-binding proteins (IGFBP-1 to IGFBP-6), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1, or sometimes with Roman Numeral as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation ...
The diagnosis of GH deficiency (GHD) in the elderly is based at present on the peak GH concentration during a stimulation test. We have now evaluated the performance of urinary GH (uGH), urinary insulin-like growth factor I (uIGF-I), and urinary IGF-binding protein-3 (uIGFBP-3) in the diagnosis of GHD in this group. Twenty GHD elderly patients with a history of pituitary disease and a peak GH response to arginine stimulation of less than 3 ng/mL (15 men and 5 women; age, 61.1-83.4 yr) and 19 controls (12 men and 7 women; age, 60.8-87.5 yr) were studied. GH secretion was assessed by 24-h profile and expressed as the area under the curve (AUCGH). Serum (s) IGF-I and sIGFBP-3 were measured in a single morning, fasted sample. Urinary GH, uIGF-I, and uIGFBP-3 were measured in a 24-h urine sample collected over the same interval as the GH profile, and results were expressed as total amount excreted in 24 h (tuGH24, nanograms; tuIGF-I24, nanograms; tuIGFBP-3(24), micrograms). Data are presented as the ...
J Clin Endocrinol Metab. 2000 Apr;85(4):1686-94.. Mauras N, OBrien KO, Welch S, Rini A, Helgeson K, Vieira NE, Yergey AL.. Division of Endocrinology, Nemours Childrens Clinic, Jacksonville, Florida 32207, USA. [email protected] We examined the effects of recombinant human (rh) insulin-like growth factor I (IGF-I) vs. rhGH in a variety of metabolic paths in a group of eight severely GH-deficient young adults using an array of contemporary tools. Protein, glucose, and calcium metabolism were studied using stable labeled tracer infusions of L-[1-13C]leucine, [6,6-2H2]glucose, and 42Ca and 44Ca; substrate oxidation rates were assessed using indirect calorimetry; muscle strength was determined by isokinetic and isometric dynamometry of the anterior quadriceps, as well as growth factors, hormones, glucose, and lipid concentrations in plasma before and after 8 weeks of rhIGF-I (60 microg/kg, sc, twice daily), followed by 4 weeks of washout, then 8 weeks ofrhGH (12.5 microg/kg-day, sc); the ...
Thank you for your interest in spreading the word on Stroke.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
TY - JOUR. T1 - Transport and binding of insulin-like growth factor I through articular cartilage. AU - Garcia, A. Minerva. AU - Szasz, Nora. AU - Trippel, Stephen. AU - Morales, Teresa I.. AU - Grodzinsky, Alan J.. AU - Frank, Eliot H.. PY - 2003/7/1. Y1 - 2003/7/1. N2 - This study focused on the role of insulin-like growth factor (IGF) binding proteins (IGFBPs) in cartilage on the transport and binding of IGF-I within the tissue. We have developed experimental and theoretical modeling techniques to quantify and contrast the roles of diffusion, binding, fluid convection, and electrical migration on the transport of IGF-I within cartilage tissue. Bovine articular cartilage disks were equilibrated in buffer containing 125I-IGF-I and graded levels of unlabeled IGF-I. Equilibrium binding, as measured by the uptake ratio of 125I-IGF-I in the tissue (free plus bound) to the concentration of labeled species in the buffer, was found to be consistent with a first-order reversible binding model involving ...
Domains of the insulin-like growth factor I receptor required for the activation of extracellular signal-regulated kinases.: The type 1 insulin-like growth fact
Aim and background. The Wilms tumor 1 gene (WT1) is overexpressed in many cancers, including breast cancer, and its high expression is an adverse prognostic factor. However, the factors that regulate WT1 expression are poorly understood. Methods and study design. Expression of genes at the RNA and protein level was detected by reverse transcriptase-polymerase chain reaction, western blotting, and reverse-phase protein array assays in breast cancer cell lines and tumor samples. Results. In the study, we showed that the treatment of MCF-7 breast cancer cells with insulin-like growth factor I (IGF-I) increases WT1 protein expression by 77%. IGF-I uses Akt to up-regulate WT1 expression. Conversely, inhibition of IGF-I by IGF-binding protein 3 and of IGF-I receptor (IGF-IR) by anti-IGF-IR antibody (b-IR3) uses Akt to decrease WT1 protein levels in MCF-7 cells. We thus newly identified a mechanism by which IGF-I up-regulates WT1, especially the (+exon 5/-KTS) isoform, at the posttranscriptional level ...
Both GH-deficiency and type 1 diabetes are associated with low IGF-I levels. The aim with our studies was to develop a dose titration model to obtain physiological IGF-I levels in growth hormone deficiency and to evaluate the relationship between glycaemic control and IGF-I in diabetes. First we established reference values for insulin like growth factor-I (IGF-I) and insulin like growth factor bindingprotein-1 (IGFBP-1) from 101 women and 101 men randomly selected from the population registry. No gender differences in IGF-I levels were fmmd. IGF-1 decreases with advancing age in both sexes, whereas IGFBP-1 increases with age.. Titrating the GH dose according to population based reference values of IGF-I might be a way to obtain a fairly physiological substitution dose of GH. We hypothesised that a safe and probably effective maintenance dose of GH should increase IGF-I to the mean or slightly below the mean according to age adjusted reference levels. Eighteen adult hypopituitary patients with ...
Results:. Serum osteocalcin and type I procollagen C-peptide increased during rhIGF-1 therapy (P , 0.05). Twenty-four hour urinary calcium, hydroxyproline, and pyridinoline cross-links were also higher after treatment than they were before treatment (P , 0.05). During 6 months of treatment, the bone mineral density of the L2 to L4 vertebrae increased 3%; this value exceeded the coefficient of variation of this measurement. Bone density at the femoral neck and radial shaft changed by less than the coefficient of variation of these measurements. No significant changes in serum glucose values or other adverse effects of treatment were noted. ...
Insulin-like growth factor I (IGF-I) enhances myofibrillar development in cardiomyocytes of rats in culture and in vivo. In addition, IGF-I has vasodilatory effects and improves cardiac function in healthy volunteers. This study was conducted to evaluate the acute hemodynamic effects of IGF-I in patients with chronic heart failure Eight patients with chronic heart failure were randomized to receive recombinant human IGF-I (60 micrograms/kg) or placebo, i.v., over 4 h in a cross-over, double blind study on 2 consecutive days. Electrocardiogram as well as systemic hemodynamics were continuously monitored over 7 h by flow-guided thermodilution and radial artery catheters. IGF-I was well tolerated by all patients, and no pathological changes on electrocardiogram were recorded. Compared with placebo, IGF-I increased the cardiac index by 27 +/- 3.7% (+/- SE; P | 0.0005) and the stroke volume index by 21 +/- 5.6% (P | 0.05), and decreased systemic vascular resistance by 28 +/- 4.4% (P | 0.0002), right atrial
Experimental evidence shows cross-talk in mammary cells between estrogen, insulin-like growth factor I (IGF-I) and their respective receptors and possible synergistic effects of estrogen receptor (ER) activation and increased IGF-I signaling with regard to breast tumor development, and epidemiological evidence suggests that circulating IGF-I levels may be related more to the risk of ER-positive than ER-negative breast cancer. Using a case-control study nested within the prospective European EPIC cohort (938 breast cancer cases and 1,394 matched control subjects), we analyzed the relationships of prediagnostic serum IGF-I levels with the risk of estrogen and progesterone receptor-positive and -negative breast tumors. IGF-I levels were positively associated with the risk of ER+ breast tumors overall (pre- and postmenopausal women combined, odds ratio (OR) Q4-Q1 = 1.41 [95% confidence interval (CI) 1.01-1.98] for the highest vs. lowest quartile; OR = 1.17 [95% CI 1.04-1.33] per 1-standard deviation (SD)
Experimental evidence shows cross-talk in mammary cells between estrogen, insulin-like growth factor I (IGF-I) and their respective receptors and possible synergistic effects of estrogen receptor (ER) activation and increased IGF-I signaling with regard to breast tumor development, and epidemiological evidence suggests that circulating IGF-I levels may be related more to the risk of ER-positive than ER-negative breast cancer. Using a case-control study nested within the prospective European EPIC cohort (938 breast cancer cases and 1,394 matched control subjects), we analyzed the relationships of prediagnostic serum IGF-I levels with the risk of estrogen and progesterone receptor-positive and -negative breast tumors. IGF-I levels were positively associated with the risk of ER+ breast tumors overall (pre- and postmenopausal women combined, odds ratio (OR) Q4-Q1 = 1.41 [95% confidence interval (CI) 1.01-1.98] for the highest vs. lowest quartile; OR = 1.17 [95% CI 1.04-1.33] per 1-standard deviation (SD)
Treatment with recombinant human insulin-like growth factor-I (IGF-I) stimulates linear growth in children with severe IGF-I deficiency (IGFD). To evaluate the efficacy and safety of treatment with IGF-I in patients with severe IGFD treated until adult or near-adult height. Twenty-one children with severe IGFD were treated until adult or near-adult ...
TY - JOUR. T1 - Insulin-like growth factor I expression in thyroid tumors. AU - Maiorano, Eugenio. AU - Ciampolillo, Anna. AU - Viale, Giuseppe. AU - Maisonneuve, Patrick. AU - Ambrosi, Antonio. AU - Triggiani, Vincenzo. AU - Marra, Ersilia. AU - Perlino, Elda. PY - 2000/6. Y1 - 2000/6. N2 - Insulin-like growth factor 1 (IGF-1) likely is involved in thyrocyte proliferation via autocrine mechanisms, but limited data are available on its in vivo expression in thyroid neoplasms. This prompted us to explore IGF-1 expression at the protein and mRNA levels and IGF-1 receptor (IGF-1rec) immunore-activity in normal and neoplastic thyroids (50 adenomas and 53 carcinomas). We documented increased IGF-1 and IGF-1rec immunoreactivity in adenomas (31 of 50 and 40 of 50 cases, respectively) and carcinomas (38 of 53 and 42 of 53 cases) compared with normal thyroid, which only showed minimal immunoreactivity for the ligand and its receptor. A corresponding up- regulation of IGF-1 mRNA was documented in ...
in Journal of Clinical Endocrinology and Metabolism (1998), 83(2), 374-8. Cabergoline is a new, long acting, dopamine agonist that is more effective and better tolerated than bromocriptine in patients with hyperprolactinemia. Because dopamine agonists still have a place in the ... [more ▼]. Cabergoline is a new, long acting, dopamine agonist that is more effective and better tolerated than bromocriptine in patients with hyperprolactinemia. Because dopamine agonists still have a place in the medical management of acromegaly, cabergoline might be a useful treatment. We, therefore, evaluated the effect of long term administration of cabergoline in a large group of unselected acromegalic patients. Sixty-four patients were included in a multicenter, prospective, open labeled study. A subgroup of 16 patients had GH-/PRL-cosecreting pituitary adenomas. Cabergoline was started at a dose of 1.0 mg/week and was gradually increased until normalization of plasma insulin-like growth factor I (IGF-I) ...
Adjuvant-induced arthritis in rats is associated with growth failure, hypermetabolism and accelerated protein breakdown. The aim of this work was to study the effects of adjuvant-induced arthritis on GH and insulin-like growth factor-I (IGF-I). Arthritis was induced by an intradermal injection of complete Freunds adjuvant and rats were killed 18 and 22 days later. IGF-I and GH levels were measured by radioimmunoassay. Pituitary GH mRNA was analyzed by northern blot and IGF binding proteins (IGFBPs) by western blot. Arthritic rats showed a decrease in both serum and hepatic concentrations of IGF-I. On the contrary, arthritis increased the circulating IGFBPs. The serum concentration of IGF-I in the arthritic rats was negatively correlated with the body weight loss observed in these animals. Arthritis decreased the serum concentration of GH and this decrease seems to be due to an inhibition of GH synthesis, since pituitary GH mRNA content was decreased in arthritic rats (p,0.01). These data ...
Semantic Scholar extracted view of Molecular and cellular aspects of the insulin-like growth factor I receptor. by Derek Leroith et al.
Title: Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications. VOLUME: 15 ISSUE: 29. Author(s):Kenji Okajima and Naoaki Harada. Affiliation:Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467- 8601, Japan.. Keywords:Insulin-like growth factor-I, sensory neurons, calcitonin gene-related peptide, nitric oxide, prostaglandins, tumor necrosis factor, apoptosis. Abstract: Insulin-like growth factor-I (IGF-I) plays various important roles in cellular proliferation, differentiation, survival and functions of the cell, thereby contributing to the maintenance of tissue integrity. Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated. Stimulation of ...
Looking for Insulin growth factor? Find out information about Insulin growth factor. somatomedin Explanation of Insulin growth factor
Popular insulin growth factor - Wholesale insulin growth factor to sell from insulin growth factor online Wholesaler of bulkingcyclesteroids.
Orthotopic transplantation of colon 38 in the cecum leads to a high degree of tumor growth in the cecum by 14 days after transplantation. Liver tumor metastases are detected 21 days after transplantation to the cecum (13) . In the present study, we transplanted colon 38 adenocarcinoma tissue fragments onto the cecum of LID mice and control mice to study the effects of reduced circulating IGF-I levels on tumor growth and the subsequent appearance of metastases. The genetic background of the mice used was a mixed background of 129sv, C57BL/6, and FVB/N. Despite this mixed genetic background, both control and LID mice developed cecum tumors and liver metastases, suggesting that the innate immunity that remained after multiple matings and breeding of these mice may have been less effective in rejecting cells from a pure C57BL/6 background. Indeed, our data showed that macroscopic palpable cecum tumors were present around 23 days after transplantation. This time course of tumor development is only ...
TY - JOUR. T1 - Insulin-like growth factors I and II and their binding proteins in rat milk. AU - Donovan, Sharon M.. AU - Hintz, Raymond L.. AU - Wilson, Darrell M.. AU - Rosenfeld, Ron G.. PY - 1991/1. Y1 - 1991/1. N2 - IGF-I and -II are peptide growth factors that may be important contributors to the growth-promoting properties associated with milk. IGF in extracellular fluids, including serum and milk, are carried by specific high-affinity binding proteins (IGFBP). In this study, the levels of IGF-I and -II in rat serum and milk were quantified by specific RIA, and the IGFBP were characterized using Western ligand blotting and autoradiography throughout lactation. The levels of IGF-I in both milk and maternal serum decreased during lactation. Serum IGF-I decreased from 743 ± 187 μg/L on d 1 to 391 ± 106 (mean ± SD) on d 21 of lactation, and milk IGF-I levels fell from 30 ± 10 to 13 ± 8 μg/L. Levels of IGF-II in serum and milk were much lower than IGF-I, and were unaffected by ...
Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival,and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to theprevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol withIGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578men and 346 women) of a nested case-control study of lung and colorectal cancer risk . Using frozen-stored sera,serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separatelydetermined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 weremeasured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI,IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI,IGF-II, and IGFBP-3 levels increased with
Rotwein P, et al. Genetic analysis of the hypervariable region flanking the human insulin gene. Am. J. Hum. Genet. 39: 291-299, 1986. PubMed: 2876625 Rotwein P, et al. Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides. J. Biol. Chem. 261: 4828-4832, 1986. PubMed: 2937782 ...