RESULTS A total of 30,266 questionnaires were returned, representing , 70% of all drug-treated diabetic patients receiving medication in the period studied. Of the diabetic patients, 63% were treated by oral medication only, 31% by insulin only, and 6% by a combination of insulin and oral agents. Of the patients in whom diabetes was diagnosed at ≥ 30 years of age, 75% were treated at health centers, whereas , 60% of those in whom diabetes was diagnosed at , 30 years of age were treated at outpatient clinics. The mean annual frequency of visits was 4.0 for patients receiving insulin treatment and 3.3 for patients receiving treatment with oral medications. The diabetic patients used 1.5 million hospital inpatient days per year, which was 13% of the total inpatient days in Finland. Of the inpatient days, 20% were for diabetes as the principal cause, 52% for diabetes-related diseases, and 28% for causes unrelated to diabetes. The direct costs of the health care of drug-treated diabetic patients in ...

PubMed journal article: Magnetic resonance imaging and diffusion-weighted imaging changes after hypoglycemic coma. Download Prime PubMed App to iPhone, iPad, or Android

The PANORAMA pan-European Survey: impact of severe and non-severe hypoglycaemia on quality of life and other patient reported outcomes in patients with type 2 diabetes [Abstract 580]. / Bradley, Clare; Eschwège, E; de Pablos-Velasco , P; Parhofer, KG; Simon, D; Tafalla , M; Pascual, E; Gönder-Frederick , LA.. In: Diabetologia, Vol. 53, No. Supplement 1, 09.2010, p. S234-235.. Research output: Contribution to journal › Article ...

We described (1) another case of hypoglycemia, also in that case many months after the start of therapy with propranolol. For this reason, although in the Hemangiol® leaflet it is not recommended to periodically check blood sugar, we have continued to have it performed by the mother periodically, also to sensitize her to the problem. However, despite this habit and the repeated advice to the mother to reduce or stop the drug when the child does not eat, we observed 2 cases of propranolol-induced hypoglycemia in 400 children treated with the drug. In the literature there is no shortage of such cases. This side effect is not probably related with the dose of the drug (2), but it is often associated with fasting, as occurred in our cases. Therefore, it is necessary to further sensitize dermatologists, pediatricians and parents to this rare but severe side effect of propranolol therapy.. ...

By now you must have heard the news that as of April 1, Medicaid in Washington State will no longer reimburse hospitals for care of what Medicaid deems unnecessary ED visits. [The Seattle Times report is here.] The problem, of course, is that many times the perceived lack of necessity can only be determined after the patient has been worked up. Even a patient brought in by ambulance will not be covered if it turns out that his illness is not a true emergency as defined by the rules. And hospitals will not be allowed to bill the patients. The unnecessary visits list includes illnesses like hypoglycemic coma and asthma attacks. Unstable vital signs do not matter if the visit is eventually found to be unnecessary ...

ASL perfusion MR imaging was first described over a decade ago12,13 and has been an active area of research.14,15 One advantage of ASL over conventional bolus tracking for perfusion measurement is that it provides absolute CBF information. Quantification of CBF facilitates the identification of cases with symmetric global perfusion abnormalities (Fig 2).. Causes of global cerebral hyperperfusion include etiologies that result in global vasodilation or loss of cerebral vascular autoregulation. Carbon dioxide is a potent vasodilator, and hypercapnia can cause transient vasodilation when cerebral perfusion autoregulation pathways are intact.16-19 This property has been exploited with tests, such as the hypercapnia challenge, to evaluate the cerebral vascular reserve.17 All of the patients in our series had normal arterial blood gas measurements except for case 6. Case 6 is a case of favorable outcome while showing global hyperperfusion. Previous studies have shown up to a 200% increase in CBF as ...

Publications | Dipanjan Roy [Google Scholar Profile] [PubFact Bibliography] [Frontiers Profile] Integration and segregation in Autism Spectrum Disorders modulated by age, disease, and interaction: A graph-theoretic study of intrinsic functional connectivity Vatika Harlalka, Shruti Naik, Raju S. Bapi, Vinod P.K., Dipanjan Roy Front. Neurosci. - Brain Imaging Methods 2017 September (in revision) Segregation and Integration of cortical…

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Over the past few years there has been an increased interest in studying the under-lying neural mechanism of cognitive brain activity in order to identify features capable of discriminating brain...

OBJECTIVE: To evaluate the clinical/research utility of the biopsycho-behavioral model of severe hypoglycemia in differentiating patients with and without a history of severe hypoglycemia and in predicting occurrence of future severe hypoglycemia. RESEARCH DESIGN AND METHODS: A total of 93 adults with type 1 diabetes (mean age 35.8 years, duration of diabetes 16 +/- 10 years, HbA1 8.6 +/- 1.8%), 42 of whom had a recent history of recurrent severe hypoglycemia (SH) and 51 who did not (NoSH), used a handheld computer for 70 trials during 1 month recording cognitive-motor functioning, symptoms, blood glucose (BG) estimates, judgments concerning self-treatment of BG, actual BG readings, and actual treatment of low BG. For the next 6 months, patients recorded occurrence of severe hypoglycemia. RESULTS: SH patients demonstrated significantly more frequent and extreme low BG readings (low BG index), greater cognitive-motor impairments during hypoglycemia, fewer perceived symptoms of hypoglycemia, and ...

There is no well documented experience with glipizide overdosage. The acute oral toxicity was extremely low in all species tested greater than 4 g/kg). Overdosage of sulfonylureas, including glipizide, can produce hypoglycemia. Mild hypoglycemic (LD50 symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL. Patients ...

Integrative theory of cognitive and sensory-motor functions in healthy aging Dipanjan Roys group is currently studying large-scale dynamics of brain networks under specific physical, anatomical constraints inferred from modern-day neuroimaging methods EEG, MEG, fMRI, DTI/DWI using resting and task conditions. Our group combines three complementary approaches Neuroimaging, Psychophysics, and Computational modeling to understand emotions,…

Ever felt your brain a little sluggish a little while after eating sugar or a giant meal? You are probably feeling the effects of a sugar crash, which, new research shows, really can slow down your cognitive function.

On a previous episode of The MythBusters, Adam and Jamie made a lead balloon float. I was impressed. Anyway, I decided to give a more detailed explanation on how this happens. Using the thickness of foil they had, what is the smallest balloon that would float? If the one they created were filled all the…. ...

While writing the previous episodes, I wondered how other people would react to them. I decided to publish them even though I think most people are not very concerned about the well-being of others. I expect most people will react … Continue reading → Continue reading →. ...

If you would have tried answering the test in the previous episode, you would have realised that even the so-called good things you would ...

Overdosage of sulfonylureas including glipizide can produce hypoglycemia. Mild hypoglycemic symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Clearance of glipizide from plasma ...

Company announcement - No. 24 / 2018 Zealand Pharma has initiated the Phase 3 trial with dasiglucagon for treatment of severe hypoglycemia in children The pediatric Phase 3 trial will enroll up to 40 children with Type 1 diabetes and evaluate time to recovery from insulin-induced low bloo...

Severe hypoglycemia was found to be an important risk factor for increased risk of short-term mortality in patients with type 2 diabetes.

It is possible to obtain coma through the total aspiration of the cerebrospinal fluid. Physiolo-gical , clinical and quantum-electrodynamics considerations about the traumatic coma are made. Ninety minutes for saving the brain.. ...

Xeris Pharmaceuticals, Inc. (Nasdaq: XERS), a specialty pharmaceutical company leveraging its novel formulation technology platforms to develop and co

Getty Images In the previous episode of our fictional saga, David had a huge win at work: His white paper led to Congress passing a single-payer health care bill, signed into law by President

Episode 2 will, like all episodes thus far, be delayed, this time it isnt waiting for editing, but waiting for everyone to all be in the same country. We promise that it wont spend as long in the cutting room as previous episodes though, so our rambling and lies will be up to date.. ...

Episode 2 will, like all episodes thus far, be delayed, this time it isnt waiting for editing, but waiting for everyone to all be in the same country. We promise that it wont spend as long in the cutting room as previous episodes though, so our rambling and lies will be up to date.. ...

In todays episode we are talking all about burnout - how it happens, how to recover naturally, which herbs to take and why meditation helps. I will also cover how long it takes to fully recover, and why so many of us in our culture experience a higher level of stress than ever before. As we mentioned in previous episodes, our society puts an emphasis on

For those who havent seen the last 2 episodes of HIMYM, be warned. There be SPOILERS ahead! I was ready. Poised to be pissed. For the first half of last weeks How I Met Your Mother (HIMYM), my BF Jeff told me I sat on the couch, scowling perpetually. In the previous episode

Welcome back! In this weekly series, we present, for your reading enjoyment, some of our favorite short stories, in easily digestible serialized episodes. Each week will contain links to the previous episodes of the story (in case you miss one). Please let us know what you think -- and if you have written a…

Welcome to health care at home In previous episode we were talking about Indigestion, let us take that conversation further. One of the major cause behind indigestion is having dinner at late hours. So, make sure that you take your dinner 3 hours prior sleeping. …. ...

I have soo many things to blog about yet so little time to spare here bcoz Im without a maid. YES, Im without a maid AGAIN! The only different than previous episode of without a maid was, last time it was with two babies but this time around, NO maid and with 3 BABIES ...

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Insulin shock therapy or insulin coma therapy (ICT) was a form of psychiatric treatment in which patients were repeatedly injected with large doses of insulin in order to produce daily comas over several weeks. It was introduced in 1927 by Austrian-American psychiatrist Manfred Sakel and used extensively in the 1940s and 1950s, mainly for schizophrenia, before falling out of favour and being replaced by neuroleptic drugs in the 1960s. It was one of a number of physical treatments introduced into psychiatry in the first four decades of the 20th century. These included the convulsive therapies (cardiazol/metrazol therapy and electroconvulsive therapy), deep sleep therapy and psychosurgery. Insulin coma therapy and the convulsive therapies are collectively known as the shock therapies. In 1927 Sakel, who had recently qualified as a doctor in Vienna and was working in a psychiatric clinic in Berlin, began to use low (sub-coma) doses of insulin to treat drug addicts and psychopaths. Having returned ...

Given that severe hypoglycemia affects 40% of insulin-treated people with diabetes (26), concern regarding the hazardous potential for severe hypoglycemia to cause brain damage continues to be a very real barrier for realizing the full benefits of intensive glycemic control (27). Patients with the highest incidence of severe hypoglycemia are most often those who maintain intensive glycemic control and, hence, are likely to have had recurrent bouts of moderate hypoglycemia. In this study, recurrent moderate hypoglycemia preconditioned the brain and protected it against brain damage and cognitive dysfunction induced by severe hypoglycemia.. In these experiments, severe hypoglycemic brain injury was consistently induced with hyperinsulinemic-hypoglycemic (,15 mg/dl) clamps that carefully controlled the depth and duration of severe hypoglycemia and avoided the confounding effects of anesthesia (28-31). The amount and distribution of neuronal damage was markedly different between the 60- and 90-min ...

BM is usually blood-borne, and most often associated with a systemic infection. From the clinical standpoint, it is important to confirm or exclude sepsis since it substantially compromises the patients prognosis. Initially bacteria accumulate in the lumen of choroid plexus capillaries located in the cerebral ventricles and in the small and medium-sized vessels of the subarachnoid space, where they induce an inflammatory response. Developing vasculitis leads to the inflammation of the arachnoid, dura mater and pia mater.. As a result of disruption to the blood-brain barrier, bacteria and inflammatory mediators (acute-phase proteins, leukotrienes, prostaglandins, among others) penetrate to the cerebrospinal fluid (CSF), thus exacerbating inflammation. In the acute phase cerebral vessels become dilated with increasing blood flow due to the influence of bacterial toxins. In later phases blood flow is reduced, which is associated with impaired vascular autoregulation(4). The cytotoxic activity of ...

Our knowledge about the risk of hypoglycaemia associated with diabetes treatment is derived from studies that often exclude elderly people. Aim of this study was to determine the incidence and risk factors for developing severe hypoglycaemia among persons aged 80 yr or older, with Type 2 diabetes me …

Erratum. Response to Comment on Pathak et al. Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S...

Several conditions that render patients unresponsive and simulate coma are considered separately because of their special significance. The vegetative state signifies an awake-appearing but nonresponsive state in a patient who has emerged from coma. In the vegetative state, the eyelids may open, giving the appearance of wakefulness. Respiratory and autonomic functions are retained. Yawning, coughing, swallowing, and limb and head movements persist, and the patient may follow visually presented objects, but there are few, if any, meaningful responses to the external and internal environment-in essence, an awake coma. The term vegetative is unfortunate because it is subject to misinterpretation. There are always accompanying signs that indicate extensive damage in both cerebral hemispheres, e.g., decerebrate or decorticate limb posturing and absent responses to visual stimuli (see below). In the closely related but less severe minimally conscious state, the patient displays rudimentary vocal or ...

Insulin in the brain may help regulate the hunger sensation and improve functional connectivity in certain cognitive brain regions. This is the finding of a new study by researchers at the German Center for Diabetes Research (DZD) in Tübingen.

John Kounios, Phyllis Koenig, Guila Glosser, Chris DeVita, Kari Dennis, Peachie Moore, Murray Grossman Cognitive Brain Research 17:484-494, 2003. Abstract Semantic memory consolidation was studied by comparing medial temporal lobe (MTL ...

Karley Wall remembers the immense frustration at having to learn how to walk, talk and feed herself again at the age of 23.. Walls life changed beyond recognition on January 17, 2001 when the car she was a passenger in crashed in the Lewis Pass. It was the day she nearly died.. Wall had to be cut from her car after the accident near the Maruia Hot Springs. She had a brain stem injury, a broken femur and fractures to her pelvis and scaphoid.. She has no memory of what happened that day and her memories of waking up after a five-week medically induced coma are also faint.. To read Karleys amazing story, click here. ...

I am absolutely floored by Ks comments. In contrast, I applaud Disney for recognizing the effects that standing or waiting in a long line can have on a person with Type 1 Diabetes. Disneys actions has likely saved many Type 1 people from a severe hypoglycemic episode. Perhaps K has never experience a severe low blood sugar episode with her loved ones - especially in a place like Disney! Unfortunately, I have a few times; although never at Disney - we have never been there. Time is critical when a hypoglycemic episode strikes. If K doesnt want to utilize the fast pass option when they all travel to Disney, he/she certainly doesnt have to! But why in the world would he/she call out those who utilize the fast pass to keep their loved ones safe? To find the practice of utilizing it deplorable, is absolutely ridiculous. Maybe K should witness a young child having a hypoglycemic episode, and then maybe he/she would understand why the fast pass is worthy for those with Type 1. Disney should be at ...

What is hyperglycemic coma, why does it develop. Varieties of coma in children and adults. Symptoms, diagnostic methods, complications. Principles of treatment and emergency care.

We began a 21-day regimen of biaxin after my surgery 1.5 years ago. Metal taste BIG time. I can live with that though. What got crazy was when I began passing out from severe hypoglycemia it would cause me to have. TAKE WITH FOOD. This happened when I would take the pill, go to mass, then come home to eat afterwards. Bad bad bad idea. Eat and then take it. Also, l could live with that, although it was scary. The last straw was 2 weeks into the 3 week course and I began having rapid and irregular heart-beats while feeling really flush. I stopped taking it at that point since I knew it just wasnt acting right with my body. As soon as I stopped taking it, all those symptoms stopped and havent been back. Sometimes I wonder if I should try it again...Unfortunately it was the only antibitotic I have taken that ever did work ...

Hi, my name is Amy and Im new to the group. I am looking for people to talk to that have gone through what I have been through--medically induced coma. I was...

Insulin coma and various types of convulsive therapies were the major biologic treatment modalities in psychiatry before the psychopharmacological era. Except for electroconvulsive therapy (ECT), these methods disappeared from the psychiatric armamentarium after the introduction of psychotropic drugs. Atropine coma therapy (ACT) was one variety of nonconvulsive coma therapy used from the 1950s in a few state mental hospitals in the United States and in several Middle- and Eastern European countries until the late 1970s. In ACT, a coma of 6-10 hours duration was induced with doses of parenteral atropine sulfate that were hundreds of times greater than the therapeutic dose administered in internal medicine. Although ACT was given to thousands of patients with a variety of diagnoses for nearly 3 decades, it is rarely mentioned, even in papers on the history of psychiatry. The method, indications, contraindications and adverse effects of ACT are summarized together with patients personal accounts. ...

Surveys of the history of psychiatric treatment, psychoanalytical therapy, behavior therapy, hypnosis, direct analysis, client-centered therapy, group treatment, psychodrama, and other methods; chapters on drug therapy, convulsive therapy, insulin coma, psychosurgery. Three chapters on milieu therapy. Evaluation of treatment.. This overview, built out of material from Comprehensive Textbook of Psychiatry, edited by the present editors, is adequate as an introduction for the novice in psychiatry or background reading for the nonpsychiatrist practitioner. ...

Circulating autoantibodies to insulin can be detected in patients with insulin-dependent (type I) diabetes mellitus (IDDM) at the onset of the clinical disease. To characterize the autoantibody response in IDDM patients, we determined the frequency of circulating B cells committed to the production of IgM, IgG, and IgA to insulin in 12 newly diagnosed IDDM patients and, for comparison, in 9 healthy subjects and 17 insulin-treated IDDM patients. We found that B cells committed to the production of anti-insulin IgG, but not IgM, autoantibodies are present at much higher frequency in the circulation of newly diagnosed IDDM patients before insulin treatment (0.209 +/- 0.142%, mean value +/- SD of total IgG-producing cell precursors) as compared with age-matched healthy controls (0.032 +/- 0.030% of total IgG-producing cell precursors). In IDDM patients who had been treated with insulin, cells producing IgG antibody to insulin were 0.177 +/- 0.139% of total IgG-producing cell precursors. Generation of IgG

Delirium, stupor and coma are common clinical states that confront clinicians in almost every medical specialty. With appropriate diagnosis and treatment, coma can often be treated successfully. Conversely, delay in diagnosis and treatment may be lethal. This monograph provides an update on the clinical approach that was laid out in the previous 3 editions.

Severe hypoglycemia (SH) can be a significant problem for patients around the world with Type 1 Diabetes Mellitus (T1DM). To avoid SH, patients need to better manage, and reduce the occurrence of, preceding mild hypoglycemia. Hypoglycemia Anticipation, Awareness and Treatment Training (HAATT), devel …

Insomnia can be a big brain dumper. Sleep plays a pivotal role in strengthening our thinking and learning powers. Lack of sleep hurts these cognitive brain processes and we are unable to be alert and focused and secondly we are unable to retain things in our minds as solidly as we can do after a sound sleep.. Remedy for Insomnia:. The best remedy to have a restful sleep is to indulge yourself in healthy activities like exercise, positive thinking and outing. It plays a big role in helping you get a good sleep. If you need some sort of supplemental help then Getting Sleepy is the best supplement available in the market. The best thing about this supplement is that it is non addictive and can be taken without the fear of having any side effect. It helps you fall asleep quickly and have a restful sleep that is boosted by sound sleep cycles. It has received many positive reviews from customers from all over the world.. ...

Mixed feelings over Aaron Echolls. The weird thing is, without the context of previous episodes, Aaron is pretty fucking awesome in this episode. He sounds so sincere in his desire to retire from acting and spend more time with his family, he spends the whole episode thinking of others, and you learn more about his abusive childhood. And Id be lying if I said I didnt feel a huge amount of satisfaction watching him take Trishs battering boyfriend to PainTown. And yet - previous episodes make it pretty clear that Aaron is just as abusive as his father was, not to mention superficial, adulterous, and just insane enough to believe his own bullshit. His takedown of Trishs boyfriend is eery and unsettling because the scene is framed as a self-righteous act when he really has no reason to be portrayed that way ...

While the number of individuals suffering from long-term unconscious events (comas and coma similar states) is proportionally small relative to the population, the family members and friends of those in comas frequently suffer from significantly negative financial and psychological effects. One of the more prevalent negative effects is the uncertainty associated with comas. Patients and their loved ones can deal with most diseases and similar conditions because they know the cause, the available treatment options and how long to expect before recovery, if recovery is possible; unfortunately these elements are lacking for those in a coma. In addition most people tend to be optimistic and the idea that a person they care about will never regain consciousness is a significant psychological burden as well as a financial one due to resources required for care. Developing a treatment to increase the probability that one recovers from a coma will not produce the overall medical benefits of a cancer or ...

HPI Onset - Sudden, acute Setting - Started when she woke up this morning Severity - 10/10! Quality - Sharp Location, Radiation - Left-sided, radiating to left shoulder Duration - 2 hours Frequency - No previous episodes Aggravating Factors - Inspiration, lying down, coughing, swallowing Alleviating Factors - Sitting up and leaning forward Associated Symptoms - palpitations What else do you want to know?

Unlearn:Records · Doc Brown // Unlearn:Radio #123 (May 2021) All previous episodes can be streamed/downloaded from iTunes: itun.es/i66s8FL Mays Doc Brown Unlearn Radio 123 May 2021

Can anybody tell me what happened at the Duke/Clemson game tonight? Somebody in the stands had a hypoglycemic episode? Marisa ---------------------------------------------------------- for HELP or to subscribe/unsubscribe, contact: [email protected] ...

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Coma et Traumatisme Crânien Dr. J. Warman Chardon, FRCPC (Neurologie) Fellow, Neurogénétique/Neuromusculaire Université dOttawa, McGill University 14 Fevrier 2014

Unfortunately, this should not be a surprise to people: A girl who came out of a coma in California has had to relearn basics and seems to have a a differe

is it just that i am too inexperienced at watching these seminars to follow along without a gargantuan effort, and the amount of brainpower required to do so fatigues my neural circuitry so badly in the first several minutes that i fall into a semi-conscious stupor? this is possible. but each time i sit down for one of these talks, i tell myself sternly, you are going to listen and understand. and during the first few minutes, i usually succeed. furthermore, if a paper was given out to to read beforehand, i do make the effort to read it, and typically i can make some sense out of it, though not 100 ...