The jet injector is a needle-free injection device that uses a high-pressure stream to penetrate the skin and deliver medication into intradermal, subcutaneous, or intramuscular tissues. Multi-dose jet injectors are a type of jet injector with a reusable fluid path that consists of the vial adapter, dose chamber, fluid pathway, and nozzle. Although credited with decades of use and the delivery of millions of doses of vaccine in the field, multi-dose jet injectors are no longer used due to evidence of cross-contamination between injections. The HSI-500 Jet Injector with Protector Cap has been designed with a disposable plastic cap that acts as a shield between the nozzle and the skin to eliminate cross-contamination between injections while maintaining a high rate of vaccine delivery to multiple patients.. The objective of this pilot safety study is to provide a preliminary indication of the ability of the jet injector to prevent cross-contamination from hepatitis B virus between volunteer ...
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An improved hypodermic jet injector system in which specifically designed adapters are used for joining conventional medicament supply vials to the hypodermic jet injector during the filling of the medicament chamber thereof whereby the valving structure may be greatly simplified and the ready substitution of one medicament for another facilitated such that there is no need to purge the injector device of the previously used medicament. The adapter comprises a relatively low-cost attachment for a medicament supply vial including a stopper-piercing needle having both a liquid passage and an air passage therein. The adapter also includes a hollow recess of a predetermined shape which has a stretchable membrane forming one wall thereof, the membrane having a zero diameter hole formed through it when the membrane is unstretched. The liquid passage of the piercing needle leads to the hollow recess. When the adapter is coupled to the nose of the hypodermic jet injector device, the membrane is distended into
BACKGROUND AND OBJECTIVE: Venipuncture is a leading cause of procedural pain for children. Jet injection of lidocaine (JIL; J-Tip) has been demonstrated to be effective in controlling intravenous (IV) placement-related pain and, due to its rapid onset, is particularly suited to emergency department (ED) use. Our objective was to increase JIL use with IV placements in our ED from 11% at baseline to 50% within 12 months. ...
PLYMOUTH MEETING, Pa., March 14, 2016-- Inovio Pharmaceuticals, Inc. announced today it has signed a definitive agreement to acquire all of Bioject Medical Technologies Inc. s assets including pioneering needle-free jet injection technology, devices, and intellectual property. Inovio will pay Bioject $5.5 million in cash and stock. Inovio will advance an...
GOLDEN, Colo. - November 27, 2018 - PharmaJet®, the maker of innovative, needle-free injection technology, today announced plans to present their latest re-search results at the World Vaccine & Immunotherapy Congress on November 29 at the Loews Coronado Bay Resort in San Diego, California. The presentation, entitled Expanding Vaccine Effectiveness with Needle-free Delivery, will be presented by Dr. Erin Spiegel, Director of Scientific Affairs at PharmaJet, Inc.. Immunotherapy is an expanding field of medicine that includes therapeutics using nucleic acid-based delivery platforms. These types of platforms, which have also been used for vaccines, rely on chemically and electrically mediated methods of delivery. PharmaJet has shown in multiple studies that needle-free jet injection works to deliver these therapeutics to cells and even augments vaccine responses, possibly by in-creased dispersion of injectate or through tissue disruption. PharmaJets Needle-free injection systems are commercially ...
High-pressure injection injuries occur when a high-pressure injection device such as a paint or grease gun injects into the operator. Commonly, this injury occurs in the dominant hand and the index finger of the operator.
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Purpose: High-pressure injection injury is caused by accidental injection of the high-pressure injection devices in industry. The initial benign appearance of the wound fools patients into delays in an adequate treatment. And it can result in disastrous outcomes such as necrosis and amputation. To avoid the poor prognosis, the injuries require a prompt surgical intervention. The purpose of this article is to recognize the poor outcome of the highpressure injection injury and to introduce an adequate treatment in need. Methods: We have 4 cases of the high-pressure injection injuries in the hand from April, 2005 to March, 2009. Average age is 39 years (30 - 49 years old), 2 cases are the palm of dominant hand, 1 case is the thumb of dominant hand, and 1 case is the palm of non-dominant hand, respectively. We followed up these patients for 20 months on average. In 3 cases, the immediate, aggressive surgical intervention was carried out, but the other one was delayed in early adequate treatment. The ...
3M™ Curos Jet™ Disinfecting Cap for Needleless Connectors is the next-generation solution for needleless connector disinfection. Meeting the high-efficacy standards of all Curos™ Disinfecting Port Protectors, Curos Jet disinfecting caps utilize 70% isopropyl alcohol (IPA) to disinfect all critical surfaces of needleless connectors. Consistent use of Curos™ Disinfecting Caps for Needleless Connectors on I.V. needleless connectors is associated with decreased CLABSI.
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0229] In the event that the user places the supplemental device 2 onto the injection pen 1 at a location such that the supplemental device 2 is slightly at the right of the position shown in FIG. 8, the locating rib 70 does not fit within the locating channel 71. In this case, the supplemental device 2 is prevented from being located fully over the injection pen 1 by the locating rib 70 resting against a surface of the supplemental device 2 that is in some way distal from the correct location within the locating channel 71. However, in this position, the ends of the protuberances 53, 54 have passed the halfway point of the circumference of the housing 10 of the injection device 1 and thus the spring 67 results in the injection device 1 being biased towards the supplemental device 2 so as to be located within the injection device receiving channel 58. A user would know that the supplemental device 2 had not mated correctly with the injection pen 1 because they would not have received any haptic ...
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For more than 65 years, the name BAUER KOMPRESSOREN has been synonymous with outstanding expertise and successful positioning as one of the worlds major market leaders in gas injection technology (GIT). BAUER not only delivers complete gas injection systems, but also provides support in the event of any questions regarding the entire gas injection process.
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A major aim of this study was to compare the safety and efficacy of the two techniques for administering the vaccine. Immunization with rV-CEA by intradermal needle injection or s.c. jet injection was associated with modest toxicity. All patients demonstrated some degree of local inflammation at the site of primary inoculation, which was comparable between the two groups. Most patients experienced pruritis at the inoculation site, which was more frequent and more intense with intradermal administration. Pruritis was self-limited and required no therapy. Systemic toxicity was limited to low-grade fever and increased fatigue, each affecting fewer than 20% of the patients. Thus, both techniques of administration were well tolerated, with no compelling reason to recommend one technique over the other, based upon toxicity profiles. Because no evidence of immune response to CEA was observed, the efficacy comparison between the two groups was based upon the induction of immune response to the vaccinia ...
Plasma free insulin profiles in insulin-dependent diabetic subjects were compared after jet and syringe injection of insulin. Jet injection of insulin resulted in a shift of the free insulin profile to the left. Thus higher plasma free insulin levels were found over the first 30 min after injection (P , 0.05), while after 240 min plasma free insulin levels were lower than those seen following syringe injection (P , 0.05). Significant differences in the response of blood glucose and 3-hydroxybutyrate levels reflected the differences in plasma free insulin levels. Jet administration results in more rapid absorption of insulin and could be useful in providing a more physiologic postprandial insulin profile than that seen after conventional injection.. ...
Transparent and heat-resistant poly(methyl methacrylate) copolymers were synthesized by bulk polymerizing methyl methacrylate (MMA), isobornyl methacrylate (IBMA), and methacrylamide (MAA) monomers. Copolymerization was performed using a chain transfer agent to investigate the molecular weight changes of these copolymers, which exhibited advantages including a low molecular weight distribution, excellent optical properties, high transparency, high glass transition temperature, low moisture absorption, and pellets that can be readily mass produced by using extrusion or jet injection for packing light-emitting diode materials.
The purpose of this study is to evaluate the immunogenicity, safety and influence of the delivery system (needle-free injector or syringe with needle) of fractional doses (dose sparing) (23,3 and 43,3 PFU - plaque-forming units - of live attenuated OKA strain of Varicella-zoster virus and 100 radioimmunoassay units HAV) of chickenpox and Hepatitis A ( vaccines, intradermally administered, compared with full dose of 103,3 PFU, subcutaneously administered, in 600 primo (first) vaccinated children aged 13 to 30 months selected at random at day care centers in São Paulo. Vaccines will be tested sequentially (Varicella on day 0 and Hepatitis A on day 45). Only 400 children will be randomized again for Hepatitis A vaccine testing, the remaining 200 children will receive the regular dose of Hepatitis A vaccine without further assessment. Doses will be administered using two systems: Disposable Needle-free Syringe Jet Injector (DSJI), compared with the conventional procedure using syringes and needles. ...
Photo courtesy of PATH/Patrick McKern. In the Stratis design, the spring is charged just by putting the device in its Reset Station, a simple mechanical case. The Reset Station compresses the spring to the proper amount by pushing metal bars of varying lengths against it. Theres no electricity involved. Once the device is charged, you literally just press a button to deliver the injection.. After pressing the button, the vaccine is delivered through a tiny opening in the tip of the syringe, roughly the width of a human hair. The pressure from the spring creates a liquid needle that pushes fluid through the skin, much like a regular needle minus the metal. Then the tip automatically disables, preventing reuse. This is actually a special feature because one big problem with a conventional needle and syringe is reuse and cross-contamination, which increase the risk of disease transmission between patients. By comparison, jet injector syringe tips eliminate the chance for reuse. Also, because ...
We assessed safety and immunogenicity of HIV-DNA priming using Zetajet,sup,TM,/sup,, a needle-free device intradermally followed by intramuscular HIV-MVA boosts, in 24 healthy Mozambicans. Volunteers were randomized to receive three immunizations of 600 µg (n = 10; 2 x 0.1mL) or 1200 µg (n = 10; 2 x 0.2mL) of HIV-DNA (3 mg/mL), followed by two boosts of 10,sup,8,/sup,pfu HIV-MVA. Four subjects received placebo saline injections. Vaccines and injections were safe and well tolerated with no difference between the two priming groups. After three HIV-DNA immunizations, IFN-γ ELISpot responses to Gag were detected in 9/17 (53%) vaccinees, while none responded to Env. After the first HIV-MVA, the overall response rate to Gag and/or Env increased to 14/15 (93%); 14/15 (93%) to Gag and 13/15 (87%) to Env. There were no significant differences between the immunization groups in frequency of response to Gag and Env or magnitude of Gag responses. Env responses were significantly higher in the ...
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3M™ Curos™ Disinfecting Cap for Needleless Connectors is an alcohol-containing cap that twists onto ports for disinfection and protection. Each Curos cap contains 70% isopropyl alcohol (IPA) which bathes the surface of the port and disinfects it in 1 minute. Consistent use of Curos disinfecting caps on I.V. needleless connectors is associated with decreased CLABSI.
TY - JOUR. T1 - In vitro study assessing the antibacterial activity of three silver-impregnated/coated mechanical valve needleless connectors after blood exposure. AU - Chernecky, Cynthia C. AU - Waller, Jennifer L. AU - Jarvis, William R.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - This in vitro studys purpose was to assess antibacterial activity of 3 different connectors: V-Link (Baxter, Deerfield, IL), Ultrasite Ag (B. Braun, Bethlehem, PA), and MaxGuard (CareFusion, Ontario, CA), impregnated with silver nanoparticles after blood exposure. All 3 silver-coated/impregnated connectors grew Staphylococcus aureus and Staphylococcus epidermidis. Log reduction of bacteria was not significant (range, +0.19 to -1.82). There was substantial bacterial recovery from all 3 connectors (mean ranges, 2.09 × 10 7 to 4.00 × 108) indicating that, once blood comes in contact with silver-coated/impregnated needleless connectors, their antibacterial activity is significantly reduced.. AB - This in vitro studys purpose ...
global insulin delivery system market, size, trends, forecasts CAGR, segment, by product type (insulin pens, insulin jet injectors, syringes, insulin pumps), by end user (specialty diabetic clinics, hospitals, retail channels), by region (Americas, Europe, Asia-Pacific, ROW)
People with type 1 diabetes no longer produce insulin, and they must have insulin injections to use the glucose, or sugar, they obtain from eating.. People with type 1 diabetes must give themselves insulin several times per day. Insulin can either be injected, which involves the use of a needle and syringe, or it can be given by an insulin pump, insulin pen, or jet injector, or inhaler. Extra amounts of insulin may be taken before meals, depending on the blood glucose level and food to be eaten.. Insulin currently cant be taken as a pill. Because its a protein, it would be broken down during digestion just like the protein in food. It must be injected into the fat under the skin for insulin to get into the blood.. New pharmaceutical materials and techniques have been developed, however, that can protect insulin from being broken down in the digestive tract. The first human trials of oral insulin were reported in 2006. Phase I clinical trials have shown insulin given in a gel capsule to be safe ...
Bioject Medical Technologies, a leading developer and manufacturer of needle-free injection technology, has announced that it has entered into a distribution agreement with Fondaco PTE, LTD, a premier medical supplies company based in Singapore. Under the terms of this agreement, Fondaco will be the exclusive distributor of Biojects commercial needle-free injection products in Singapore, Indonesia, and Malaysia.. Products positioned for distribution through this agreement include the full portfolio of Bioject technologies including the Biojector® 2000 needle-free injection system and theBioject® ZetaJet™ portable injector. In September 2013, Bioject also announced an international distribution agreement with iHealthnet LLC for distribution of Bioject products in markets including South Asia, India and the Middle East.. We have seen significant demand for advanced needle-free technologies in global markets including Asia in recent years. Through collaboration with established industry ...
In the past few decades, scientists have developed various alternatives to hypodermic needles. For example, nicotine patches slowly release drugs through the skin. But these patches can only release drug molecules small enough to pass through the skins pores, limiting the type of medicine that can be delivered. With the delivery of larger protein-based drugs on the rise, researchers have been developing new technologies capable of delivering them - including jet injectors, which produce a high-velocity jet of drugs that penetrate the skin. While there are several jet-based devices on the market today, Hogan notes that there are drawbacks to these commercially available devices. The mechanisms they use, particularly in spring-loaded designs, are essentially bang or nothing, releasing a coil that ejects the same amount of drug to the same depth every time.. Breaching the skin. Now the MIT team, led by Ian Hunter, the George N. Hatsopoulos Professor of Mechanical Engineering, has engineered a ...
Needle Free Drug Delivery Market Analysis & Trends - Product (Microneedles, Nanopatches, Electronically Assisted Transport, Intranasal), Technology (Jet Injectors, Transdermal Patch Technology, Oral Drug Delivery - Market research report and industry analysis - 10509859
The Centers for Disease Control and Prevention and the Food and Drug Administration monitor the flu vaccine. It is made from a dead virus and cannot give a person the flu. Two vaccines are designed for people ages 65 and older - the high dose vaccine and Fluad. Seniors should not receive the nasal spray, intradermal or jet injector flu vaccines.. Life-threatening reactions to the vaccine are rare. It can have mild side effects such as soreness, redness, headaches, muscle aches, fever, and nausea. The two vaccines designed for seniors may result in more of these mild side effects.. Several viruses cause the flu, and the vaccine is intended to match up with the viruses that are circulating each year. Studies show the vaccine reduces the risk of flu illness by 40 to 60 percent when the vaccine is matched well with the viruses circulating that year.. Related link: Flu prevention: 3 smart strategies. ...
The Centers for Disease Control and Prevention and the Food and Drug Administration monitor the flu vaccine. It is made from a dead virus and cannot give a person the flu. Two vaccines are designed for people ages 65 and older - the high dose vaccine and Fluad. Seniors should not receive the nasal spray, intradermal or jet injector flu vaccines.. Life-threatening reactions to the vaccine are rare. It can have mild side effects such as soreness, redness, headaches, muscle aches, fever, and nausea. The two vaccines designed for seniors may result in more of these mild side effects.. Several viruses cause the flu, and the vaccine is intended to match up with the viruses that are circulating each year. Studies show the vaccine reduces the risk of flu illness by 40 to 60 percent when the vaccine is matched well with the viruses circulating that year.. Related link: Flu prevention: 3 smart strategies. ...
A meningococcal group B (15:P1.3) outer membrane protein vaccine was tested for efficacy in a randomized, double-blind controlled study in Iquique, Chile. A total of 40 811 volunteers, ages 1-21 years, enrolled in the study. Volunteers received two doses of vaccine six weeks apart by jet injector. B …
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A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is placed in the bore of a barrel with the barrel having the shape of a nose cone at one end. A plunger is inserted into the other end of the bore. The plunger forces the medicament through the skin and into the subcutaneous layer of the patient without the need for penetration of the skin by a needle.
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Amid a global shortage of injectable IPV, countries in the WHO South-East Asia Region are opting to use fractional doses of IPV, an evidence-based intervention that not only ensures continued protection of children against all types of polio viruses, but also helps save vaccine - a move bound to positively impact global vaccine supply in the coming years, said Poonam Khetrapal, WHO Regional Director for South-East Asia.. India became the first country globally to introduce fractional doses of IPV in childhood immunisation programme in eight of its 36 states / union territories in early 2016. The initiative is now being scaled up nationwide. Sri Lanka followed suit in July 2016. Bangladesh has decided to introduce fractional IPV doses this year. Other countries in the region are also considering a shift to the use of fractional IPV doses in their immunisation schedule, Khetrapal added.. According to WHO, studies have confirmed two fractional doses (one fractional dose is one-fifth of a full ...
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PERTH, Australia, Oct. 9 -- Orbital announced today that Kwang Yang Motor Co. Ltd (Kymco) have publicly stated that they are developing Kwang Yang Direct Injection (KDI) for planned introduction on certain100cc and 50cc scooter models scheduled to be launched next year. Kymco, established in 1963 and one of Taiwans leading motorcycle manufacturers, produces more than 300,000 scooters and motorcycles a year for both the Taiwanese market and a growing export market. KDI, which incorporates the Orbital Combustion Process (OCP) has been developed as a result of 7 years of cooperation between Orbital and Kymco.
A system is provided that is useful for hypodermic injection of medication without piercing the skin with a needle. The system includes a gas pressure actuated needleless hypodermic injection device f
ihealthnets needle-free injection technology can be utilized in almost every domain where subcutaneous,intramuscular or intradermal injections are employed.Some commonly utilized applications include:Immunization,Diabetes,Rheumatoid arthritis,Cancer.
The exact meaning of the medical terminology,Jet injector - A device that uses high pressure to propel insulin through the skin and into the body, is clearly explained in Medindia s glossary of medical terms
Takedas push to lead the gastrointestinal (GI) field may have raised a few eyebrows at its inception, but the long-term strategy is now paying impressive dividends. The recent EMA approval of the subcutaneous formulation of its Inflammatory Bowel Disease (IBD) drug Entyvio was another milestone, as well as an important boost for patients.. Takeda is now also focused on a needle-free jet injector application that would broaden choice for patients even further, a crucial advance, as the three million people in Europe living with Crohns disease or ulcerative colitis is expected to rise by around 25% by 2025, according to recent studies.. The success has been hard won. Entyvio, a monoclonal antibody, was shrouded with early theoretical safety concerns that clipped expectations until a suite of innovative and comprehensive trials reported positively and the company has amassed more than 500,000 patient years experience over the products six years.. There were tremendous challenges at the start ...
The Asia Pacific needle free injection system market is anticipated to grow at a CAGR of 16.5% during 2016 to 2022. The market has generated the revenue $ 2062 million in 2016 and is anticipated to reach up to $ 5143 million by 2022. Needle free technology is also called as jet injectors. It is widely used in mass vaccination programs for patients suffering from polio, smallpox, and measles, it keeps product supply cleaner. Needle free injection systems are new tradition by which a variety of medicines are introduced in patients without piercing the skin with the use of conventional needle. These systems functions on the mechanism in which medicine, in the form of liquid is forced with an eminent speed through a petite orifice that is held against the skin. Needle free injection system consists of technologies, which do not have a needle but make use of electrophoresis to drive drugs through the skin. This technology avoid several weakness associated with the conventional needle, such as risk of ...
Pen needles are used in conjunction with injection pens to deliver injectable medications into the body. A pen needle consists of a hollow needle which is embedded in a plastic hub and attaches to injection pens. Pen needles come in a variety of needle lengths and diameters and are used by health professionals and patients for injection of a variety of medications. They are commonly used by people with diabetes who often require multiple daily insulin injections. Needle technology has changed over the past decades. Many years ago home use syringe needles were large, and had to be sterilized and sharpened by hand by patients themselves. Todays pen needles are engineered and manufactured for greater comfort and ease of use with electro-polishing for needle smoothness; thin, fine point tips for ease in penetration; lubrication for less friction and more glide; plastic caps for safety; and individual wrapping for sterility. Injection pen and pen needles are an alternative drug delivery method to ...
with a reduced reaction rate. Current research is directed toward development of a vaccine consisting principally of one or more of the bacterial components thought to provide protection. Prominent candidate antigens include filamentous hemagglutinin and lymphocytosis promoting factor (pertussis toxin). However, several years will be necessary to complete development and to document the potency, safety, and efficacy of a new vaccine. VACCINE USAGE The standard single-dose volume of DTP, DT, Td, single-antigen adsorbed preparations of pertussis vaccine, tetanus toxoid, and diphtheria toxoid, and the nonadsorbed tetanus toxoid is 0.5 ml. Adsorbed preparations should be administered intramuscularly (IM). Vaccine administration by jet injection may be associated with more frequent local reactions. (See also: ACIP: General recommendations on immunization. MMWR 1983;32:1-8,13-7.) Primary Immunization Children 6 weeks through 6 years old (up to the seventh birthday) (Table 1). One dose of DTP should be ...
Needle-free injection devices and drug delivery systems are disclosed. The needle-free injection devices may include a drug delivery system, a power source, an activation system, and a disabling element. The drug delivery system may include a needle-free syringe and a drug storage system. The needle-free syringe may include a plunger slidably disposed within an injection chamber. The injection chamber may include an injection orifice, and the plunger may be configured to expel a volume of fluid from the injection chamber through the injection orifice. The drug storage system may include a storage chamber and an outlet. The drug storage system may be frangibly connected to the needle-free syringe with the outlet proximate to and fluidly connected with the injection orifice. The drug storage system may be configured to inject a fluid from the storage chamber through the outlet, through the injection orifice, and into the injection chamber.
Following physical examination, radiological evaluation including at least bilateral direct graphies should be definitely carried out, and additional investigations such as CT, MRI etc. should be ordered if deemed necessary in all patients with foreign body penetration or high-pressure injection injuries [5]. In addition, tetanus prophylaxis should not be neglected in all patients. The presence of a neglected foreign body may lead to complications including infection, pain, loss of function, joint damage, tenosynovitis, tendon rupture and osteomyelitis, and amputation [7]. In daily practice; the foreign bodies that were accidentally identified and remained for years without damaging the patient, and those stuck in the subfascia and/or in bones without any impact on comfort and functions of the patient may not be removed. Contamined and massive intraarticular bodies or those causing potential dysfunction must be removed [12]. Whereas in high-pressure injection injuries; the injected irritant ...
The Causes: Equipment such as paint or grease guns, diesel engine fuel injectors, hydraulic lines and pressure washers are all capable of emitting enough pressure to breach the human skin and inject contents into the human body which can cause workplace high pressure injection injuries.. Only 100 pounds per square inch (psi) is required to break intact human skin.. First Aid: Workers with injection injuries may experience little or no pain at the time of the incident. Entry wounds are frequently small or appear insignificant.. Any injury suspected to be from high pressure injection Must be treated as Surgical Emergencies and RTC to appropriate facility.. All details, including injection substances (SDSs or non-hazardous materials ie: air, water) and observations must be recorded and accompany the injured worker.. Emergency Response Plans must include the name and contact information for qualified surgeons located at a minimum of 2 local hospitals. They must be notified that a worker has (or ...
To the Editor:-Prevention of needle stick injury is a major issue in the operating room. Various needleless systems are available to avoid this risk. [1,2] We have been using a needleless intravenous access system (InterLink Injection Site; Baxter Healthcare, Deerfield, Ill, and InterLink Syringe Cannula, Becton Dickinson, Franklin Lakes, NJ) in our pediatric intensive care unit and operating room for the past year, and are satisfied, in general. We did however, experience a single incident of skin injury caused by this system ...
In March 1985, during routine investigation of hepatitis B (HB) case reports, an epidemiologist at the Long Beach (California) Department of Public Health noted that three HB patients had each received injections at the same weight-reduction clinic (clinic A) before disease onset. When review of previous case records and questioning of newly reported HB patients identified five additional HB cases among clinic attendees, the California Department of Health Services joined in the investigation of the clinic on July 1, 1985. Clinic A belonged to a chain of 29 weight-reduction clinics located throughout southern California. Attendees at the clinics typically received a series of daily parenteral injections of human chorionic gonadotropin (HCG). Injections were usually given by jet injectors (Med-E-Jet Corp, Cleveland, Ohio), although some attendees received injections with single-use disposable needles and syringes. A standard regimen consisted of 30 injections; however, individuals varied ...
a) Ingredients, preservatives, diluents, adjuvants. All ingredients used in a licensed product, and any diluent provided as an aid in the administration of the product, shall meet generally accepted standards of purity and quality. Any preservative used shall be sufficiently nontoxic so that the amount present in the recommended dose of the product will not be toxic to the recipient, and in the combination used it shall not denature the specific substances in the product to result in a decrease below the minimum acceptable potency within the dating period when stored at the recommended temperature. Products in multiple-dose containers shall contain a preservative, except that a preservative need not be added to Yellow Fever Vaccine; Poliovirus Vaccine Live Oral; viral vaccines labeled for use with the jet injector; dried vaccines when the accompanying diluent contains a preservative; or to an Allergenic Product in 50 percent or more volume in volume (v/v) glycerin. An adjuvant shall not be ...
The threat posed by this years 2009 pandemic H1N1 virus emphasized the need for new influenza A virus vaccines inducing a broad cross-protective immune response for use in both humans and pigs. vaccine, convenient for mass vaccinations, was compared with intradermal needle injection followed by electroporation. We statement that when our DNA vaccine is usually expressed by the new vectors and delivered to the skin with the needle-free device in the rabbit model, it can elicit an antibody response with the same titers as a conventional vector with intradermal electroporation. The needle-free delivery is already in use for traditional protein vaccines in pigs but should be considered as a practical alternate for the mass administration of broadly protective influenza DNA vaccines. electroporation is the practical difficulty of the method with regard to its tolerability in humans, animal welfare and inconvenience in mass vaccinations. One additional mode of delivery demonstrating the effective ...
This revision of the General Recommendations on Immunization updates the 1989 statement. Changes in the immunization schedule for infants and children include recommendations that the third dose of oral polio vaccine be administered routinely at 6 months of age rather than at age 15 months and that measles-mumps-rubella vaccine be administered routinely to all children at 12-15 months of age. Other updated or new sections include a) a listing of vaccines and other immunobiologics available in the United States by type and recommended routes, advice on the proper storage and handling of immunobiologics, a section on the recommended routes for administration of vaccines, and discussion of the use of jet injectors; b) revisions in the guidelines for spacing administration of immune globulin preparations and live virus vaccines, a discussion of vaccine interactions and recommendations for the simultaneous administration of multiple vaccines, a section on the interchangeability of vaccines from ...
The NovoLog® FlexPen®: a dial-a-dose, pre-filled insulin pen for discreet mealtime management that is easy for patients to use. Review FlexPen® benefits, storage and needles information.
[05-06-2011] The U.S. Food and Drug Administration (FDA) is alerting the healthcare community about syringe connection problems when certain needleless glass syringes containing the cardiac drugs adenosine and amiodarone are used with particular types of intravenous (IV) access systems.
A syringe is a simple reciprocating pump consisting of a plunger (though in modern syringes its actually a piston) that fits tightly within a cylindrical tube called a barrel. The plunger can be linearly pulled and pushed along the inside of the tube, allowing the syringe to take in and expel liquid or gas through a discharge orifice at the front (open) end of the tube. The open end of the syringe may be fitted with a hypodermic needle, a nozzle or a tubing to help direct the flow into and out of the barrel. Syringes are frequently used in clinical medicine to administer injections, infuse intravenous therapy into the bloodstream, apply compounds such as glue or lubricant, and draw/measure liquids. The word syringe is derived from the Greek σύριγξ (syrinx, meaning tube) via back-formation of a new singular from its Greek-type plural syringes (σύριγγες). Sectors in the syringe and needle market include disposable and safety syringes, injection pens, needleless injectors, ...
Novorapid (Novolog in the United States) are the brand names for Novo Nordisks fast-acting type of human insulin aspart.. When Novorapid is injected, it is extremely fast-acting, and works rapidly to normalize blood sugar levels. It typically begins working after 10-20 minutes, and will last for between 3 and 5 hours. It may be injected before a meal, and sometimes immediately after, to ensure strict control of post-prandial levels.. Novo Nordisk has designed some unique insulin pens that allow for easy injection. These are called NovoRapid FlexPen.. ...
Insulin Pen Cap Market: Global Demand Analysis & Opportunity Outlook 2024. The global insulin pen cap market is segmented into distribution channel such as online stores and offline stores. Additionally, online stores captured the largest segment in 2016 and it is expected to acquire at a remarkable CAGR during the forecast period. In addition to this, easy availability of the product through online distribution channel is envisioned to elevate the global market of online stores. Further, increasing number of population affected with diabetes is believed to be major factor propelling the growth of insulin pen cap market. Moreover, technological advancement in the field of healthcare products is also believed to spur the growth insulin pen cap market. Global insulin pen cap market is anticipated to register a significant CAGR over the forecast period. Moreover, the global insulin pen cap market is projected to reach at noteworthy revenue by 2024. The market of insulin pen cap is riding on the ...
Our search identified five liquid stocks that are buy candidates.. Antares Pharma, Inc. (Nasdaq: ATRS) is a pharmaceutical company that has developed three proprietary platforms, two of which now include FDA approved products. The company focuses on self-injection pharmaceutical products and technologies and topical gel -based products. Its subcutaneous injection technology platforms include Vibex™ disposable pressure-assisted auto injectors, Vision® reusable needle-free injectors, and disposable multi-use pen injectors. The company has strategic alliances and partnership arrangements with Teva Pharmaceutical Industries, Ltd.; AMAG Pharmaceuticals, Inc.; Ferring Pharmaceuticals Inc.; and Ferring B.V.. Analysts have a price target of $4.66 on ATRS, indicating this stock could gain more than 50% from its current level.. BioDelivery Sciences International, Inc. (Nasdaq: BDSI) is a specialty pharmaceutical company that focuses on the development and commercialization of pain management and ...
It has been reported that the direction of the guidewire J-tip is associated with misplacement of a central venous catheter. We hypothesized that real-time ultrasound-guided infraclavicular subclavian venous cannulation would be less influenced by th
Series 62 Constant-Differential Relays serve as air-flow controllers maintaining a constant air purge for each setting of an integral needle valve.; Series 63 Constant-Differential Relays are used in conjunction with an external needle valve to provide constant volume flow rates of liquids or gases over a continuously adjustable range.; The Model 66 Amplifying and Reducing Relays are used to Learn More ...
For this purpose the air of the reference atmosphere is conveyed with a constant volume flow rate through a combined mesh-filter probe. The fraction of the short-lived radon-222 progenies, which are attached to aerosols, are deposited to the filter. The free (unattached) fraction is adsorbed to the wire mesh.. The activity collected at the filter and the mesh, respectively, decays according to the radioactive decay law. The activities of the alpha-emitting nuclides are measured in periodic time intervals. The associated graphic representation is denominated as decay curve.. Immediately after sampling the decay curves of the filter and mesh alpha activity are measured, respectively. An algorithm is used to deduce the potential alpha-energy concentration and unattached part of the short-lived radon-222 progenies. ...
For this purpose the air of the reference atmosphere is conveyed with a constant volume flow rate through a combined mesh-filter probe. The fraction of the short-lived radon-222 progenies, which are attached to aerosols, are deposited to the filter. The free (unattached) fraction is adsorbed to the wire mesh.. The activity collected at the filter and the mesh, respectively, decays according to the radioactive decay law. The activities of the alpha-emitting nuclides are measured in periodic time intervals. The associated graphic representation is denominated as decay curve.. Immediately after sampling the decay curves of the filter and mesh alpha activity are measured, respectively. An algorithm is used to deduce the potential alpha-energy concentration and unattached part of the short-lived radon-222 progenies. ...
Gerresheimers plastics and devices division is composed of the medical plastic systems, plastic packaging and syringe systems business units.. It manufactures high-quality, customised drug delivery systems, diagnostics and medical products, focusing on inhalers, injection pens, lancing devices, laboratory disposables and point-of-care tests.. The company provides services across the creation chain, ranging from concept development to mould making and special-purpose machinery engineering in order to move medical device concepts from initial idea to market-ready products.. The Medical Plastic Systems unit develops complex plastic systems and components for customers in the pharmaceutical, diagnostics and medical technology sectors. The unit provides an individual service across all supply chain processes.. The Plastic Packaging units portfolio includes plastic packaging systems for liquid and solid pharmaceuticals. Administration and dosing systems such as eye drop or nasal spray bottles and ...
Haselmeier has received Master File Number MAF3202 from the Food and Drug Administration (FDA) of the United States for its D-Flex product platform, a new generation of injection pen systems for subcutaneous self-administration.
Cancer is one leading causes of death worldwide. Gene therapy belongs to the promising options for treatment of malignant tumors. The non-viral gene therapy is known as safer alternative to the viral gene therapy. For non-viral gene transfer the vector and the transfer technology are of crucial importance. As part of this work a clinical trial was performed to assess efficiency and safety of the non-viral jet-injection. It was shown, that this technology can be used safely in a clinical setting. As a result of this clinical trial we concluded, that vector safety and especially efficiency need further improvements. Based on this optimized non-viral vectors (minicircle, MIDGE) were compared with each other and their respective parental plasmids. The MIDGE vector showed the highest transgene expression due to increased transcription. In preparation of a clinical trial the combined treatment of hTNF-alpha gene transfer and Vindesine chemotherapy was analyzed. Again, the MIDGE vector showed the ...
The University of Texas at Austin (Austin, TX)-Relationships Between Induced Seismicity and Fluid Injection: Development of Strategies to Manage Fluid Disposal in Shale Hydrocarbon Plays. The research team will seek to learn why fluid disposal induces earthquakes in some areas and not in others, with the aim of developing improved injection technology that optimizes disposal volume and cost while avoiding induced seismicity. The project includes a survey of seismic activity in four basins; acquisition of data concerning injection locations, histories, and volumes; spatial and temporal correlation analysis of injection and earthquake activity; collection of structural data in study areas that show different levels of seismic activity; geomechanical and statistical analysis; and development of improved injection strategies. DOE share: $963,792; Recipient share: $259,123; Duration: 2 ...
LDM® adapts to any anti-aging and dermatology concept LDM® can be effectively combined with light and radio-frequency treatments, filler and injections, and be used by pre- and post-operative treatments in aesthetic and plastic surgery. This injections technology will optimize your clients results. Once tried, clients will want to continue with LDM®. On behalf of SKIN MANAGEMENT and BODY MANAGEMENT concepts of LDM® has been developed and tested for several anti-aging therapies as well as dermatological ap-plications and body treatments.. LDM-MED (Germany) is based on dual-frequency ultrasound waves and is able to modulate dynamic processes of production and destruction within connective tissue which is of primary importance in different applications.. ...
In the reaction $\ce{N2 (g) + O2(g) -, 2NO (g)}$ my textbook[1] says $q_v$ and $q_p$ are not the same, without any explanation.. I know that \begin{align} \Delta U &= q_p + w\\ \Delta U &= q_p - P\Delta V\\ \Delta U &= q_p - Δn_\mathrm{gases}RT \end{align}. I also know that $$\Delta U = q_v.$$. because under constant volume, work done ($-P\Delta V$) is zero, since theres no change in volume. In the reaction mentioned, $$n_\mathrm{gases} = 0,$$ so ...
This study analyzes the factors influencing the thermal efficiency of a homogeneous charge spark-injection (SI) engine fuelled with hydrogen, focusing on the degree of constant volume and cooling loss. The cooling loss from the burning gas to the cylinder walls is quantitatively evaluated by analyzi
If you have diabetes and use an insulin pen, odds are you dont live in the United States.. A new patient in Europe, depending on the country, is not even taught how to use insulin in a vial anymore, says John Holcombe, MD, senior clinical research physician for diabetes care at Eli Lilly.. Lilly estimates that only 12 percent of insulin users in the United States use either prefilled disposable insulin pens or insulin cartridges in reusable pens.. The advantages are that [insulin pens] are very accurate, especially with low doses of insulin, says Holcombe. You can consistently give accurate doses with a pen device compared to drawing that same amount of insulin up with a syringe.. So why have insulin pens, despite these advantages and Americans penchant for convenience, failed to catch on in the United States?. There are a couple of reasons, explains Javan Collins, diabetes brand leader at Lilly. There is a different healthcare system in Europe in which the government-or national ...
The nurses, physicians and parents questioned in this survey considered reliability to be the most important attribute that they required from an r-hGH injection device. Device reliability encompasses not only the ability of the device to deliver the injection of r-hGH each time it is used, but also to confirm that the correct dose has been administered. To ensure reliability, an r-hGH administration device must be robust enough to withstand daily use and handling by young children. It is understandable that reliability is considered to be so important to those using r-hGH injection devices because, if a device stops functioning, the patient/parent may need help to get it repaired, and this must be done quickly to ensure continuity of treatment. Repairs may involve driving to the pharmacy/hospital, which is both inconvenient and time-consuming. For some devices, technical support is available over the phone to help patients/parents rectify problems with their device at home.. Of the devices they ...
Hydraulic fracturing (also hydrofracturing, hydrofracking, fracking or fraccing) is a well-stimulation technique in which rock is fractured by a pressurized liquid. The process involves the high-pressure injection of fracking fluid (primarily water, containing sand and other proppants suspended with the aid of gelling agents) into a wellbore to create cracks in the deep-rock formations through which natural gas, petroleum, and brine will flow more freely. When the hydraulic pressure is removed from the well, small grains of hydraulic fracturing proppants (either sand or aluminium oxide) hold the fractures open.. Hydraulic fracturing began as an experiment in 1947, and the first commercially successful application followed in 1950. As of 2012, 2.5 million frac jobs had been performed worldwide on oil and gas wells; over one million of those within the U.S. Such treatment is generally necessary to achieve adequate flow rates in shale gas, tight gas, tight oil, and coal seam gas wells. Some ...
A Regional market Analysis is a quantitative and qualitative assessment of a Diabetes Insulin Pen market. It looks into the size of the Diabetes Insulin Pen business by 2020 both in volume and in value, the various customer segments and Diabetes Insulin Pen buying patterns, the competition, and the economic environment in terms of barriers to entry and regulation. Knowledge is power. It helps businesses strengthen their position. Use market research to gain a better perspective and understanding of Diabetes Insulin Pen market and target audience and ensure you stay ahead of the competition. These regions include- North America, Asia-Pacific, Europe, Africa, South America and the Rest of the world. Also, countries included are U.S., Canada, Mexico, U.K., France, Germany, Italy, China, India, Russia, The Middle East, South-East Asia and so on. ...
A device for automatically disinfecting a portion of a medical implement. The device includes a reservoir chamber having a top external opening, a medical implement protruded through a bottom part of the reservoir chamber with the portion to be disinfected exposed inside the reservoir chamber and below the top external opening, two disinfecting pads, and a resilient device. Each disinfecting pad is connected to the reservoir chamber through a mounting member, which permits displacement of the disinfecting pads relative to the reservoir chamber in substantially opposite directions thereby creating a gap between each pad and the portion to be disinfected. The resilient device biases the disinfecting pads such that when the disinfecting pads are displaced from a rest position, wherein they are contacting the portion to be disinfected, to an engaged position, the disinfecting pads are urged to return toward the portion to be disinfected to contact and disinfect the portion.
Those looking to get the flu shot without the prick of a needle are out of luck. After receiving questions about the vaccination method, the FDA says its never approved a flu vaccine administered Read more...
QuickLink: Needle-Free Patch Makes Vaccination as Easy as Putting on a Band-Aid - The new product could be available in about five years, scientists say.The patch has several advantages over traditional needle vaccinations. Obviously, the painlessness is a selling point. But more importantly, the vaccines dont need to be refrigerated. In testing, theyve remained effective after more than a year, even at temperatures of 100 degrees Fahrenheit.
Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines Academic Article ...
The introduction of novel devices is the latest trend among players operating in the worldwide needle-free drug delivery devices market.
A new needle-free flu vaccine patch revved up the immune system much like a traditional flu shot without any negative side effects. The research represents an important step toward a technology that could replace needle-based vaccination methods that are difficult to deploy in developing countries.
Our needle-free drug delivery technology enables the administration of high viscosity biologic drugs with less discomfort and without the anxiety of handling needles
1 Answer - Posted in: lantus, lantus solostar, diabetes, type 2, insulin - Answer: It does sting a bit more when cold also it can develop bubbles ...
Many people who grow mushrooms order varieties not native to the areas where they live. Mushroom spore shipments arrive suspended in liquid inside spore syringes. The spore syringe looks exactly like a needle-less syringe used in medicine. Since it takes very little of the spore solution to start a batch of mushrooms, ...
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Whether its a strong cheek bone, or some volume in the apple of the cheek, filler can help shape and define this area adding contour to the face. Find
The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high-transverse momentum trigger hadron in p-Pb collisions at $\sqrt{s_{\rm NN}} =5.02$ TeV. Jets are reconstructed from charged-particle tracks using the anti-$k_{\rm T}$ algorithm with resolution parameter $R=0.2$ and $0.4$. A data-driven statistical approach is used to correct the uncorrelated background jet yield. Recoil jet distributions are reported for jet transverse momentum $15,~p_{\rm T,jet}^{\rm ch} ,~50$ GeV/$c$ and are compared in various intervals of p-Pb event activity, based on charged-particle multiplicity and zero-degree neutral energy in the forward (Pb-going) direction. The semi-inclusive observable is self-normalized and such comparisons do not require the interpretation of p-Pb event activity in terms of collision geometry, in contrast to inclusive jet observables. These measurements provide new constraints on the magnitude of jet quenching in small ...
The purpose of this randomized, parallel-group, single-blinded, single center, Phase II study is to collect data to compare the comfort and patient...
The most promising mechanisms for producing and accelerating relativistic jets, and maintaining collimated structure of relativistic jets involve magnetohydrodynamical (MHD) processes. We have investigated the magnetic dissipation mechanism in relativistic jets via relativistic MHD simulations. We found that the relativistic jets involving a helical magnetic field are unstable for the current-driven kink instability, which leads to helically distorted structure in relativistic jets. We identified the regions of high current density in filamentary current sheets, indicative of magnetic reconnection, which are associated to the kink unstable regions and correlated to the converted regions of magnetic to kinetic energies of the jets. We also found that an over-pressured relativistic jet leads to the generation of a series of stationary recollimation shocks and rarefaction structures by the nonlinear interaction of shocks and rarefaction waves. The differences in the recollimation shock structure