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Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1...
ID Proteins Regulate Diverse Aspects of Cancer Progression and Provide Novel Therapeutic Opportunities | Garvan Institute of...
The inhibitor of differentiation (ID) proteins are helix-loop-helix transcriptional repressors with established roles in stem cell self-renewal, lineage commitment, and niche interactions. While deregulated expression of ID proteins in cancer was identified more than a decade ago, emerging evidence has revealed a central role for ID proteins in neoplastic progression of multiple tumor types that often mirrors their function in physiological stem and progenitor cells. ID proteins are required for the maintenance of cancer stem cells, self-renewal, and proliferation in a range of malignancies. Furthermore, ID proteins promote metastatic dissemination through their role in remodeling the tumor microenvironment and by promoting tumor-associated endothelial progenitor cell proliferation and mobilization. Here, we discuss the latest findings in this area and the clinical opportunities that they provide.Molecular Therapy (2014); doi:10.1038/mt.2014.83.
Quotes containing the term: ga-binding protein transcription factor
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NANObits: A molecular switch to stop inflammation - MYSM1
Pattern-recognition receptors (PRRs) including Toll-like receptors, RIG-I-like receptors, and cytoplasmic DNA receptors are essential for protection against pathogens but require tight control to avert inflammatory diseases. The mechanisms underlying this strict regulation are unclear. MYSM1 was previously described as a key component of epigenetic signaling machinery. We found that in response to microbial stimuli, MYSM1 accumulated in the cytoplasm where it interacted with and inactivated TRAF3 and TRAF6 complexes to terminate PRR pathways for pro-inflammatory and type I interferon responses. Consequently, Mysm1 deficiency in mice resulted in hyper-inflammation and enhanced viral clearance but also susceptibility to septic shock. We identified two motifs in MYSM1 that were essential for innate immune suppression: the SWIRM domain that interacted with TRAF3 and TRAF6 and the metalloproteinase domain that removed K63 polyubiquitins. This study identifies MYSM1 as a key negative regulator of the ...
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Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MGGAAGTG which matches annotation for GABPA: GA binding protein transcription factor, alpha subunit 60kDa GABPB2: GA binding protein transcription factor, beta sub…
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、超過三十日之案件、涉及特定使用者權利而由他人為之者、該案件不受理。
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GABPA (GA binding protein transcription factor subunit alpha)
GABPA (GA binding protein transcription factor subunit alpha), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
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另外3有網友在批踢踢兔上開設「張爸「板3而「張爸「也曾在2005年活動於該板上》然而由於「張爸「發言常與其意見分歧者發生言語衝突3使不少網友對其反感3發出不滿之聲》而張爸一再散發內容相似的文章也造成許多網友閱讀上的不便3甚至迫使批踢踢站方利用程式「封殺「相關文章與推文》這些舉動讓「張爸現象「逐漸淡出批踢踢3在網路似有消退的趨勢3不過「張爸「仍然不定時地利用新申請的ID3以發文或推文的方式散播其網址3而PTT站方只要接獲使用者通報即立刻刪除該ID與封鎖用來申請ID的e-mail》只要「張爸「一出現3使用者立刻會以「樓上張爸「來警告其他使用者以免誤點網址》在批踢踢 批踢踢兔等各大佈告欄上仍有「張爸「貼文的蹤跡3「張爸現象「也曾受到部份媒體相關報導 ...
SHE-- 環保安全健康: 二月 2013
另外3有網友在批踢踢兔上開設「張爸「板3而「張爸「也曾在2005年活動於該板上》然而由於「張爸「發言常與其意見分歧者發生言語衝突3使不少網友對其反感3發出不滿之聲》而張爸一再散發內容相似的文章也造成許多網友閱讀上的不便3甚至迫使批踢踢站方利用程式「封殺「相關文章與推文》這些舉動讓「張爸現象「逐漸淡出批踢踢3在網路似有消退的趨勢3不過「張爸「仍然不定時地利用新申請的ID3以發文或推文的方式散播其網址3而PTT站方只要接獲使用者通報即立刻刪除該ID與封鎖用來申請ID的e-mail》只要「張爸「一出現3使用者立刻會以「樓上張爸「來警告其他使用者以免誤點網址》在批踢踢 批踢踢兔等各大佈告欄上仍有「張爸「貼文的蹤跡3「張爸現象「也曾受到部份媒體相關報導 ...
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Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2...
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equipment shunned by fly fishers - Joint Conference on Digital Libraries and cDNA Libraries
Primarily based on these observations, we concluded that the phenotype-genotype discordance on this affected person with MPS II was because of the decreased quantity of IDS protein induced by the low degree of the alternatively spliced mRNA, missing a part of the area coding for the sign peptide however together with the area coding nearly the complete mature IDS protein. The primary 25 amino acids on the N-terminus of IDS protein are a sign peptide. The choice splice transcript has solely 13 (1 M-13 L) of these 25 amino acids; 14G-25G are lacking, suggesting that the solely hydrophobic 1 M-13 L of the sign peptide of IDS may need a vital function within the sign peptide ...
cdna amd - Joint Conference on Digital Libraries and cDNA Libraries
Primarily based on these observations, we concluded that the phenotype-genotype discordance on this affected person with MPS II was because of the decreased quantity of IDS protein induced by the low degree of the alternatively spliced mRNA, missing a part of the area coding for the sign peptide however together with the area coding nearly the complete mature IDS protein. The primary 25 amino acids on the N-terminus of IDS protein are a sign peptide. The choice splice transcript has solely 13 (1 M-13 L) of these 25 amino acids; 14G-25G are lacking, suggesting that the solely hydrophobic 1 M-13 L of the sign peptide of IDS may need a vital function within the sign peptide ...
OriGene - Gabpa (NM 001108841) Human ORF cDNA Clone
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Synonymous many to many model relationship in Django - Stack Overflow
def get_all_synonymous_words(word): # Start with the words own synonymous words, and their synonymous words found_syn_ids = set(word.synonymous.values_list(id, flat=True)) , set(word.synonymous.values_list(synonymous, flat=True)) while found_syn_ids: words = Word.objects.filter(id__in=found_syn_ids) batch_syn_ids = set(words.values_list(synonymous, flat=True)) # If the batch syn ids are equal to last batch ids, all relationships found if batch_syn_ids == found_syn_ids: return batch_syn_ids found_syn_ids = batch_syn_ids ...
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type: thumb-down, id: missingTheInformationINeed, label:Missing the information I need },{ type: thumb-down, id: tooComplicatedTooManySteps, label:Too complicated / too many steps },{ type: thumb-down, id: outOfDate, label:Out of date },{ type: thumb-down, id: samplesCodeIssue, label:Samples/Code issue },{ type: thumb-down, id: otherDown, label:Other ...
Testing and Debugging
type: thumb-down, id: missingTheInformationINeed, label:Missing the information I need },{ type: thumb-down, id: tooComplicatedTooManySteps, label:Too complicated / too many steps },{ type: thumb-down, id: outOfDate, label:Out of date },{ type: thumb-down, id: samplesCodeIssue, label:Samples/Code issue },{ type: thumb-down, id: otherDown, label:Other ...
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Today, you will find a wide variety of drugs and steroids in the market, which are often used for various purposes and in different fields. Many of these drugs were[…]. ...
Евгений Качман | IDS - Международная школа стоматологии
Доктор Качман Евгений. DMD( Доктор Медицины).. Заведующий отделением инфекционных болезней вирусных гепатитов В и С и ВИЧ/СПИД в центральной клинической больнице Ихилов в Тель-Авиве.. Дипломированный специалист по инфекционным болезням, вирусным гепатитам В и С ВИЧ/СПИДУ, а также по инфекционным осложнениям после пересадки органов.. Специализация по инфекционным заболеваниям в Университете Торонто, Онтарио, (Канада).. Автор 11 научных статей.. Медицинское образование:. Медицинская школа имени Саклера, Тель-Авивский университет.. Диплом получен в 1996 ...
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A few programs that support ID3v2. If you know of any ID3v2 supporting software that is not on the list, please contact us. NOTE: These programs have not been checked for ID3v2 compliance by id3.org. ...
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INSERT INTO bookmarks(users_id,lessoninfo_id) VALUES( (SELECT _id FROM Users WHERE User=+$(#user_lesson).html()+), (SELECT _id FROM lessoninfo WHERE Lesson=+lesson_no+ AND cast(starttime AS int)=+Math.floor(result_set.rows.item(markerCount-1).starttime)+) WHERE NOT EXISTS ( SELECT users_id,lessoninfo_id from bookmarks WHERE users_id=(SELECT _id FROM Users WHERE User=+$(#user_lesson).html()+) AND lessoninfo_id=( SELECT _id FROM lessoninfo WHERE Lesson=+lesson_no+ ...
PATCH 2/4] d3dx9/tests: Add tests for effect state manager.
Signed-off-by: Paul Gofman ,gofmanp at gmail.com, --- dlls/d3dx9_36/tests/effect.c , 139 +++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 139 insertions(+) diff --git a/dlls/d3dx9_36/tests/effect.c b/dlls/d3dx9_36/tests/effect.c index 5362dac..fe37a2f 100644 --- a/dlls/d3dx9_36/tests/effect.c +++ b/dlls/d3dx9_36/tests/effect.c @@ -5427,12 +5427,18 @@ static HRESULT WINAPI test_ID3DXEffectStateManagerImpl_SetMaterial(ID3DXEffectSt static HRESULT WINAPI test_ID3DXEffectStateManagerImpl_SetLight(ID3DXEffectStateManager *iface, DWORD index, const D3DLIGHT9 *light) { + struct test_ID3DXEffectStateManagerImpl *state_manager = impl_from_ID3DXEffectStateManager(iface); + + IDirect3DDevice9_SetLight(state_manager-,device, index, light); return test_process_set_state(iface, 2, index, 0); } static HRESULT WINAPI test_ID3DXEffectStateManagerImpl_LightEnable(ID3DXEffectStateManager *iface, DWORD index, BOOL enable) { + struct test_ID3DXEffectStateManagerImpl *state_manager = ...
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type: thumb-down, id: missingTheInformationINeed, label:Missing the information I need },{ type: thumb-down, id: tooComplicatedTooManySteps, label:Too complicated / too many steps },{ type: thumb-down, id: outOfDate, label:Out of date },{ type: thumb-down, id: samplesCodeIssue, label:Samples / code issue },{ type: thumb-down, id: otherDown, label:Other ...
Immunregulatory function of the deubiquitin... ID:19091
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