There are no specific protocols for Recombinant Human Inhibin beta A protein (ab119449). Please download our general protocols booklet
The contribution of specific follicle populations to dimeric inhibin production and inhibin subunit mRNA expression by the rat ovary has been investigated in two model systems, granulosa cells isolated from 25-day-old diethylstilboestrol (DES)-treated rats and post-natal rat ovaries, dispersed in culture or whole ovaries, using specific two-site immunoassays and real time PCR. Media from FSH-stimulated granulosa cell cultures fractionated by gel filtration and RP-high performance liquid chromatography revealed two predominant peaks of alpha subunit activity which were attributed to alpha subunit and 31 k dimeric inhibin-A. The corresponding inhibin-B levels were low. FSH stimulation did not alter the ratio of inhibin-A:alpha subunit produced by granulosa cells. All three inhibin subunit mRNAs were expressed by granulosa cells, with eight-fold more alpha subunit mRNA relative to either of the beta subunits. Administration of DES to immature rats prior to the isolation of granulosa cells from ...
TY - JOUR. T1 - Significance of inhibin in reproductive pathophysiology and current clinical applications. AU - Kumanov, Philip. AU - Nandipati, Kalyana C.. AU - Tomova, Analia. AU - Robeva, Raliza. AU - Agarwal, Ashok. PY - 2005/6. Y1 - 2005/6. N2 - The human reproductive process is regulated by complex mechanisms that involve many organs, including the brain, gonads and endocrine system. It has been more than 70 years since the name inhibin was used to describe a substance produced in the gonads that negatively regulates pituitary secretion. Inhibin B controls FSH secretion via a negative feedback mechanism. It is a glycoprotein hormone secreted by the Sertoli cells of the testis and granulosa and theca cells of the ovary. Serum inhibin B concentrations are positively related to testicular volume and sperm counts. Current understanding of inhibin physiology and pathology in the human suggests that inhibin B may be of importance as a marker of Sertoli cell function in men with infertility and ...
TY - JOUR. T1 - Synthetic peptide segments of inhibin α- and β-subunits. T2 - Preparation and characterization of polyclonal antibodies. AU - Saito, Seiichi. AU - Roche, Patrick C.. AU - McCormick, Daniel J.. AU - Ryan, Robert J.. PY - 1989/8. Y1 - 1989/8. N2 - The amino acid sequences of human inhibin α-, βA- and βB-subunits were analyzed for hydrophilicity and chain flexibility to predict regions that are on the surface of the subunits and, therefore, are potential antigenic sites. Based on these analyses, a total of nine peptides were synthesized, and rabbit antisera against the peptides were prepared. Peptides of the N-terminus (residues 1-16 and 13-24) and region 109-123 of the a-subunit produced high titer antibodies. Regions 69-79 and 93-105 of the βB-subunit and region 93-104 of the βB-subunit were also immunogenic. Immunoblotting of an inhibin preparation with anti-a-peptide antiserum revealed that a 32K band (inhibin) and an 18K band (α-subunit) were stained. Immunoblotting ...
A protein fraction from human testis was structurally investigated. The main component of the fraction reported to contain inhibin-like activity was purified an
INHIBIN A, TUMOR MARKER. Males: ,2.0 pg/mL. Females. ,11 years: ,4.7 pg/mL. 11-17 years: ,97.5 pg/mL. Premenopausal: ,97.5 pg/mL. Postmenopausal: ,2.1 pg/mL. INHIBIN B. Males 0-23 months: ,430 pg/mL. 2-4 years: ,269 pg/mL. 5-7 years: ,184 pg/mL. 8-10 years: ,214 pg/mL. 11-13 years: ,276 pg/mL. 14-17 years: ,273 pg/mL. Adults: ,399 pg/mL. Females. 0-23 months: ,111 pg/mL. 2-4 years: ,44 pg/mL. 5-7 years: ,27 pg/mL. 8-10 years: ,67 pg/mL. 11-13 years: ,120 pg/mL. 14-17 years: ,136 pg/mL. Premenopausal. Follicular: ,139 pg/mL. Luteal: ,92 pg/mL. Postmenopausal: ,10 pg/mL. ...
INHIBIN A, TUMOR MARKER. Males: ,2.0 pg/mL. Females. ,11 years: ,4.7 pg/mL. 11-17 years: ,97.5 pg/mL. Premenopausal: ,97.5 pg/mL. Postmenopausal: ,2.1 pg/mL. INHIBIN B. Males 0-23 months: ,430 pg/mL. 2-4 years: ,269 pg/mL. 5-7 years: ,184 pg/mL. 8-10 years: ,214 pg/mL. 11-13 years: ,276 pg/mL. 14-17 years: ,273 pg/mL. Adults: ,399 pg/mL. Females. 0-23 months: ,111 pg/mL. 2-4 years: ,44 pg/mL. 5-7 years: ,27 pg/mL. 8-10 years: ,67 pg/mL. 11-13 years: ,120 pg/mL. 14-17 years: ,136 pg/mL. Premenopausal. Follicular: ,139 pg/mL. Luteal: ,92 pg/mL. Postmenopausal: ,10 pg/mL. ...
Hi there, I have been having my inhibins drawn pretty regularly after my recent mastectomy for DCIS. They have continually risen since that time. Inhibin A is 2.6 and Inhibin B is 77. I just saw my onc...
Inhibin beta B antibody [C3], C-term (inhibin, beta B) for ICC/IF, IHC-P, WB. Anti-Inhibin beta B pAb (GTX108408) is tested in Human samples. 100% Ab-Assurance.
The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and Western blotting have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (a, beta(A) and beta(B)). In the breeding season ovary, all three subunits were present in granulosa cells, theca cells of antral follicles and interstitial cells, with the strongest immunostaining in granulosa cells. Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. In the nonbreeding season ovary, inhibin/activin a and beta(A) subunits were weakly immunopositive in granulosa cells of early stage follicles, while beta(B) subunit was undetectable. The ...
In adult sheep, inhibin expression in developing follicles appears to be associated with antrum formation. Our objective was to investigate using in situ hybridization and immunohistochemistry whether antral follicles present before birth in the sheep expressed mRNA or peptide for inhibin α- and βA-subunits. At days 70 and 100 when only primordial and primary follicles were present, there was no detectable mRNA or peptide for either inhibin subunit. By days 130 and 140 (term = 145 days), many secondary follicles were present, a proportion of which (∼50%) expressed detectable levels of α-subunit mRNA but not peptide. A number of antral follicles were present by this stage, all of which expressed α-subunit mRNA and peptide. Expression of βA-subunit mRNA and peptide was undetectable at all stages of gestation. Our results indicate that even in non-ovulatory follicles present before birth, expression of inhibin, at least the α-subunit, is developmentally linked with antrum formation ...
During the later stages of follicular growth (Figure 2), activins and estradiol, the predominant estrogen in humans, enhance the actions of FSH (65, 66) (Figure 2). In mice, activins activate the transcription factors SMAD2/3 and SMAD4, which coordinately regulate several FSH-induced genes including those encoding the cell cycle regulator CCND2 and the steroidogenic enzyme aromatase (67), which converts theca cell-derived androgens to estradiol. Estradiol, acting primarily via estrogen receptor beta (ERS2), has recently been shown to suppress expression of phosphodiesterase 1C (Pde1c), thereby increasing intracellular levels of cAMP induced by FSH (66). Because activins facilitate proliferation of granulosa cells and enhance FSH actions, in part by increasing estradiol, these interactions may help explain why, when activin actions are unopposed by inhibins (as occurs in mice lacking inhibin α subunit, which is encoded by Inha), activins promote GCT growth. The WNT signaling target β-catenin ...
A synthetic nonapeptide, which is C-terminal sequence of 94-amino acid of prostatic inhibin peptide was tested for progesterone and estrogen secretion by mouse granulosa cell cultures. Nonapeptide suppressed the progesterone and estrogen synthesis, the magnitude of suppression was highest at 5 ng dose level for progesterone and 50 ng dose level for estradiol. The study suggests that, nonapeptide exerts its effect by impairing the binding of FSH to granulosa cell receptors. ...
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916; however, it was not demonstrated to exist until Neena Schwartz and Cornelia Channings work in the mid 1970s, after which both proteins were molecularly characterized ten years later. Activin is a dimer composed of two identical or very similar beta subunits. Inhibin is also a dimer wherein the first component is a beta subunit similar or identical to the beta subunit in activin. However, in contrast to activin, the ...
Unconjugated estriol (uE3-estriol) and dimeric inhibin A (DIA) are two of the tests that are part of the quadruple prenatal screening panel (quad screen), which is performed on maternal serum during the second trimester of pregnancy. Which of the following tests are also included on the quad screen ...
Human Activin A is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. MACS® GMP Recombinant Human Activin A is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives. - Sverige
Human Activin A ELISA Kit is a sensitive (| 12 pg/ml) immunoassay suitable for the quantification of Activin A in Cell culture supernatant, Serum, Other biological fluids, Tissue Extracts samples.
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Blood Testing for Inhibin B at a private BMI hospital in the UK, over 100 tests to select, add further tests at considerable discount.
Inhibin a (human) Recombinant Protein, Invitrogen™ 10μg; Unlabeled Inhibin a (human) Recombinant Protein, Invitrogen™ Proteins I
Alcohol intake was not significantly associated with serum inhibin B, FSH or LH levels in either group of men.. Observational study: Alcohol intake is associated with poorer semen quality, but positively associated with total and free testosteron ...
INHIBIN A, TUMOR MARKER. Males: ,2.0 pg/mL. Females. ,11 years: ,4.7 pg/mL. 11-17 years: ,97.5 pg/mL. Premenopausal: ,97.5 pg/mL. Postmenopausal: ,2.1 pg/mL. INHIBIN B. Males 0-23 months: ,430 pg/mL. 2-4 years: ,269 pg/mL. 5-7 years: ,184 pg/mL. 8-10 years: ,214 pg/mL. 11-13 years: ,276 pg/mL. 14-17 years: ,273 pg/mL. Adults: ,399 pg/mL. Females. 0-23 months: ,111 pg/mL. 2-4 years: ,44 pg/mL. 5-7 years: ,27 pg/mL. 8-10 years: ,67 pg/mL. 11-13 years: ,120 pg/mL. 14-17 years: ,136 pg/mL. Premenopausal. Follicular: ,139 pg/mL. Luteal: ,92 pg/mL. Postmenopausal: ,10 pg/mL. ...
Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.. PLoS One. 2010;5(3):e9457. Authors: Zhu J, Braun EL, Kohno S, Antenos M, Xu EY, Cook RW, Lin SJ, Moore BC, Guillette LJ, Jardetzky TS, Woodruff TK ...
Az aktivin és az inhibin két, hasonló szerkezetű dimer fehérjekomplex, amelyeknek egymással ellentétes élettani hatása van. Az 1986-ban felfedezett[1][2] aktivin fokozza a follikuluszstimuláló hormon (FSH) szintézisét és kiválasztását és részt vesz a menstruációs ciklus szabályozásában. A test más részeiben egyéb funkciói is vannak, például a sebgyógyulásban és a magzati fejlődés során.[3] Ezzel szemben az inhibin gátolja az FSH termelését.[4] Az inhibin létezését már 1916-ban is feltételezték, de csak a 70-es években mutatta ki az amerikai Neena Schwartz és Cornelia Channing.[5]. Az aktivin két egyforma vagy nagyon hasonló béta-alegységből áll. Az inhibin két alegysége közül az egyik szintén az aktivinével azonos béta; a másik viszont egy, csak kevéssé hasonlító alfa-alegység.[6][7]. ...
Description: 96 well plateCatalog No: RS01E1533 Organism species : Mus musculus (Mouse) Sample type : Serum, plasma and other biological fluids. Format : 96-well strip plate Assay length : 4.5 hours Detection range : 15.63-1000pg/mL The standard curve concentrations used for the ELISAs were 1000pg/mL, 500pg/mL, 250pg
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Inhibin, beta B, also known as INHBB, is a protein which in humans is encoded by the INHBB gene. INHBB is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects. Inhibins are heterodimeric glycoproteins composed of an α subunit (INHA) and one of two homologous, but distinct, β subunits (βA or βB, this protein). mRNA for the two subunits has been demonstrated in the testes of adult rats. Inhibin can bind specifically to testicular interstitial cells throughout development and may be an important regulator of Leydig cell testosterone production or interstitial cell function. The inhibin beta B subunit joins the α subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as ...
Members of the activin family are believed to act as mesoderm-inducing factors during early amphibian development. Little is known, however, about mesoderm formation in the mammalian embryo, and as one approach to investigating this we have studied activin and follistatin expression during early mouse development. Activins are homo- or heterodimers of the beta A or beta B subunits of inhibin, itself a heterodimer consisting of one of the beta subunits together with an alpha subunit. Follistatin is a single-chain polypeptide which inhibits activin function. Expression of the inhibin alpha chain could not be detected in embryonic or extraembryonic tissues at any of the stages studied (5.5 to 8.5 days) and expression of the beta A and beta B subunits could only be observed in the deciduum in cells surrounding the embryo. Expression of follistatin could also be detected in the deciduum, but in a pattern complementary to that of the beta subunits. Embryonic expression of follistatin first occurred in ...
Daily administration of 1,3-DNB resulted in decreased testis weight only on day 5 and only at the high dose (6 mg/kg/day). There was a time-dependent increase in incidence and severity of testicular findings characterized by degeneration of the germinal epithelium with loss of pachytene spermatocytes and vacuolization of the Sertoli cells in the seminiferous tubules at the high dose. Inhibin B levels in 1,3-DNB-treated animals were decreased with treatment only on day 5 at the high dose; there were no associated changes in follicle stimulating hormone. ...
The N-methyl-d-aspartate receptor plays a critical role in the formation and maintenance of synapses during brain development. In the rodent, changes in subunit expression and assembly of the heteromeric receptor complex accompany these maturational processes. However, little is known about N-methyl-d-aspartate receptor subunit expression during human brain development. We used in situ hybridization to examine the distribution and relative abundance of NR1, NR2A and NR2B subunit messenger ribonucleic acids in the hippocampal formation and adjacent cortex of 34 human subjects at five stages of life (neonate, infant, adolescent, young adult and adult). At all ages, the three messenger ribonucleic acids were expressed in all subfields, predominantly by pyramidal neurons, granule cells and polymorphic hilar cells. However, their abundance varied across ontogeny. Levels of NR1 messenger ribonucleic acid in CA4, CA3 and CA2 subfields were significantly lower in the neonate than all other age groups. In the
The N-methyl-d-aspartate receptor plays a critical role in the formation and maintenance of synapses during brain development. In the rodent, changes in subunit expression and assembly of the heteromeric receptor complex accompany these maturational processes. However, little is known about N-methyl-d-aspartate receptor subunit expression during human brain development. We used in situ hybridization to examine the distribution and relative abundance of NR1, NR2A and NR2B subunit messenger ribonucleic acids in the hippocampal formation and adjacent cortex of 34 human subjects at five stages of life (neonate, infant, adolescent, young adult and adult). At all ages, the three messenger ribonucleic acids were expressed in all subfields, predominantly by pyramidal neurons, granule cells and polymorphic hilar cells. However, their abundance varied across ontogeny. Levels of NR1 messenger ribonucleic acid in CA4, CA3 and CA2 subfields were significantly lower in the neonate than all other age groups. In the
Serum AMH concentration was significantly higher in subjects with a live birth from the first cycle or after three cycles of stimulated IUI treatment compared with those failing treatment. Serum AMH concentration has a modest predictive value on ovarian overresponse.
Inhibin B as a serum marker of psermatogenesis: Correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men ...
TY - PAT. T1 - A bacterium salmonella harboring siRNA against Inhibin alpha and antitumoral composition thereof. AU - Kim, Chul Yong. AU - Chae, Yang Seok. PY - 2015/8/7. Y1 - 2015/8/7. N2 - 인히빈 알파 siRNA를 발현하는 살모넬라 균주 및 이를 함유하는 항암제 조성물. AB - 인히빈 알파 siRNA를 발현하는 살모넬라 균주 및 이를 함유하는 항암제 조성물. M3 - Patent. M1 - 10-1544602. ER - ...
In modern clinics, AMH - an important hormone test for women with PCOS has proven effective in women who do not necessarily show any signs of PCOS and those with undiagnosed PCOS in the previous years. And from the Sofat Infertility Centre, women can get this treatment at really low cost as compared to other clinics.
OUTLINE: This is a pilot, prospective study.. Patients undergo a transvaginal or transabdominal ultrasound to measure the ovarian volume and count the number of antral follicles at baseline, 3 months after beginning cytotoxic chemotherapy, and at 6 months after completion of treatment. Patients undergo blood collection at the same time points for follicle-stimulating hormone, estradiol, and inhibin B levels. Patients are also asked to fill out questionnaires on estrogen-depletion symptoms at those times. Patients also keep a calendar of menstrual bleeding and hormonal medications.. PROJECTED ACCRUAL: A total of 22 patients will be accrued for this study. ...
A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary.. Mol Cell Endocrinol. 2011 Aug 6;342(1-2):64-72. Authors: Kim SY, Zhu J, Woodruff TK ...
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TY - JOUR. T1 - Serum Inhibin Concentration in Dogs with Adrenal Gland Disease and in Healthy Dogs. AU - Brömel, C.. AU - Nelson, Richard W. AU - Feldman, Edward C. AU - Munro, C. J.. AU - Kass, Philip H. AU - Vico, A. E.. AU - Labelle, P.. AU - Conley, Alan J. PY - 2013/1. Y1 - 2013/1. N2 - Background: Studies in humans identified the synthesis and secretion of inhibin from adrenocortical tumors, but not pheochromocytoma (PHEO). Inhibin has not been examined in dogs as a serum biomarker for adrenal gland tumors. Objective: To determine serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. Animals: Forty-eight neutered dogs with adrenal disease including pituitary-dependent hyperadrenocorticism (PDH, 17), adrenocortical tumor (18), and PHEO (13), and 41 healthy intact or neutered dogs. Methods: Prospective observational study. Dogs were diagnosed with PDH, adrenocortical tumor (hyperadrenocorticism or noncortisol secreting), or PHEO based on clinical signs, ...
Background: Anti-Müllerian hormone (AMH) and inhibin B (INHB) are two hormones investigated as markers of ovarian reserve in female. serum AMH and INHB levels change through the progression of puberty, and might be markers for identifying pubertal progression rate in girls.. Objective and hypotheses: To invetigate serum AMH and INHB levels as markers of pubertal progression rate in girls with central precocious puberty (CPP).. Method: A total of 128 girls were enrolled, 65 with premature thelarche (PT) and 63 with CPP according to GnRH stimulation tests. serum AMH and INHB levels were also accessed in all the girls on the diagnosis. Girls with CPP underwent a six-month follow up for pubertal advancement, height acceleration, and bone-age maturation. Based on these criteria, the participants were assigned to two subgroups: progressive CPP (P-CPP) group (n=50) and slowly progressive CPP (SP-CPP) group (n=13). An additional 20 age-matched healthy girls were evaluated for AMH and INHB.. Results: ...
TY - JOUR. T1 - Evidence for local production of inhibin A and activin A in patients with ovarian endometriosis. AU - Reis, Fernando M.. AU - Di Blasio, Anna M.. AU - Florio, Pasquale. AU - Ambrosini, Guido. AU - Di Loreto, Carla. AU - Petraglia, Felice. PY - 2001. Y1 - 2001. N2 - Objective: To evaluate the expression of inhibin A and activin A in ovarian endometriosis. Design: Uncontrolled cross-sectional study and controlled prospective in vitro study. Setting: Academic health centers in Siena, Udine, Sassari, and Milan, Italy. Patient(s): A group of women (n = 19) who underwent laparoscopic excision of ovarian endometriotic cysts. Intervention(s): Specimens of serum, peritoneal fluid, and cystic fluid, ovarian tissue for immunohistochemistry, and endometriotic cells for primary culture were collected. Cell cultures were also prepared from proliferative endometrium of women without endometriosis. Main Outcome Measures(s): Dimeric inhibin A and activin A concentrations in biological fluids; ...
Fetal male sexual differentiation is driven by two testicular hormones: testosterone (synthesized by interstitial Leydig cells) and antimullerian hormone (AMH; produced by Sertoli cells present in the seminiferous tubules). Intersex states result either from gonadal dysgenesis, in which both Leydig and Sertoli cell populations are affected, or from impaired secretion or action of either testosterone or AMH. Until now, only Leydig cell function has been assessed in children with ambiguous genitalia, by means of testosterone assay. ...