The potential adult adverse health outcomes that result from exposures during early life are recognized. However, only limited attention has been paid to the effect(s) of environmentally relevant toxicant exposures during critical periods of development and even fewer studies have examined whether early life inhalation exposures leads to adult disease. Our research is investigating whether inhalation exposures to real world dust during development can lead to changes in lung function and structure in adults. If so, what are the critical times of exposure that lead to those changes? Using metal-containing real world dusts collected from an abandoned mine tailings site, we have exposed male and female mice only in utero, only post-natally or continuously (in utero and postnatal inhalation exposures). We have found that significant changes in lung function and structure are only seen in adult male mice following continuous exposures. In addition, alterations in protein expression of airway cells ...
INTRODUCTION: Increased use of nanomaterials has raised concerns about the potential for undesirable human health and environmental effects. Releases into the air may occur and, therefore, the inhalation route is of specific interest. Here we tested copper oxide nanoparticles (CuO NPs) after repeated inhalation as hazard data for this material ... read more and exposure route is currently lacking for risk assessment. METHODS: Rats were exposed nose-only to a single exposure concentration and by varying the exposure time, different dose levels were obtained (C × T protocol). The dose is expressed as 6 h-concentration equivalents of 0, 0.6, 2.4, 3.3, 6.3, and 13.2 mg/m(3) CuO NPs, with a primary particle size of 10 9.2-14 nm and an MMAD of 1.5 μm. RESULTS: Twenty-four hours after a 5-d exposure, dose-dependent lung inflammation and cytotoxicity were observed. Histopathological examinations indicated alveolitis, bronchiolitis, vacuolation of the respiratory epithelium, and emphysema in the lung ...
To assess acute inhalation toxicity, MRD-95 -247 was administered via individual whole-body inhalation chambers for four hours to two groups of ten Crl:CDBR rats at either an estimated aerosol concentration of 5247 mg/m3 or an analytical concentration of 5266 mg/m3 (5213 mg/m3 aersol, 53 mg/m3 vapor). Animals were observed for fourteen days following exposure. No mortality was observed, and all animals that received the estimated aerosol concentration of 5247 mg/m3 were free of gross pathological abnormalities. In the second group (5266 mg/m3 aerosol), 4 males and 1 female exhibited red foci on the lungs, one male displayed dark red nasal turbinates, and 3 males and 1 female had alopecia and/or scabs on the dorsal surface, extremities, and/or head. Based on the conditions of this study, the LC50 for acute inhalation exposure to an aerosol atmosphere of MRD-95 -247 is greater than 5266 mg/m3. This finding does not warrant classification of MRD-95-247 as an acute inhalation toxicant under the new ...
The behavioral effects induced by methyl-n-amyl ketone (110430) (MAK) exposure were studied. Rats received from one to eight intraperitoneal injections (group I) of 18, 37, 74, or 175 milligrams per kilogram (mg/kg) MAK, or were exposed to MAK aerosols (Group II) of 800 to 1,900 parts per million (ppm) daily for 6 or 8 hours. Following inhalation exposures, the rats were given injections of 37, 74
OBSH is used as a blowing agent in industrial processing and for professional uses. For systemic effects from long term inhalational exposure, no inhalational study is available. A DNEL of 0.7 mg/m3 was established based on a NOAEL of 10 mg/kg bw/d from an oral OECD 408 90D study. For local effects in respiratory tract from long term inhalational exposure a DNEL of 0.1 mg/m3 is applicable based on a ACGIH TLV of 0.1 mg/m3 for OBSH derived to protect against effects from hydrazine liberated from hydrolysis of OBSH. For systemic effects from long term dermal exposure, no dermal study is available. A DNEL of 0.1 mg/kg/d was established based on a NOAEL of 10 mg/kg bw/d from an oral OECD 408 90D study with rats. Short term exposure is controlled by conditions for long-term exposure, therefore no DNEL has been established. Further, as OBSH has been identified as a skin sensitizer, strict control measures should apply. ...
TY - CONF. T1 - Gas phase synthesis of TiO2-nanoparticles for inhalation exposure studies. AU - Miettinen, Mirella. AU - Tapper, Unto. AU - Backman, Ulrika. AU - Joutsensaari, Jorma. AU - Auvinen, Ari. AU - Jokiniemi, Jorma. PY - 2008. Y1 - 2008. M3 - Conference article. T2 - European Aerosol Conference 2008, EAC 2008. Y2 - 25 August 2008 through 29 August 2008. ER - ...
Complete solutions for a variety of inhalation exposure test assays. We develop and produce a wide range of equipment and components for in-vivo and in-vitro studies with aerosols and vapors.. Our exposure systems are suitable for long- and short-term inhalation investigations with test animals or cell cultures involving toxicity and impact of particulate matter, e.g. in pharmacology, environmental and occupational safety, and bio-defense studies.. The exposure system design and Daco inhalation software for automatic control and regulation of experiments support you in achieving compliance with the OECD, EPA and GLP guidelines.. ...
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Adverse health effects by inhaled and deposited particles are of great concern. In addition, therapeutic aerosols become increasingly important for the treatment of lung and other diseases. The interaction of particles with the inner surface of the lungs is fundamental for their biological effectiveness in the organism, though poorly understood and precluded from being studied in humans. A large number of animals are used to test the effects of aerosol particles on a living system by whole-body or nose-only exposures. Such experiments are time consuming and they are stressful for the animals. Furthermore, the increase of knowledge in the use of animal models is hampered for various reasons, such as the long time lapse between aerosol application and lung fixation, the lack of methods for direct studies, or artefacts produced by chemical lung fixation. Cell cultures which are in common use today are deficient in important structural components of the inner lung surface, such as macrophages, ...
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The general population is exposed to CDFs by inhalation, ingestion of drinking water, consumption of food, and through the use of certain consumer products. Since the concentrations of CDFs in ambient air and drinking water are low (see Section 5.4), the intake of CDFs by inhalation and ingestion of drinking water would be low. It has been shown that inhalation exposure was not a major pathway of human exposure to CDFs (Travis and Hattermer-Frey 1989). The estimate that inhalation exposure.... ...
In case of a radioactive release, it is important to have good preparedness with the right actions to contribute the best protection for the vulnerable section of the population. Immediately after a release theexposure through inhalation will be the biggest problem, since particles and gases have not beendeposited on land, clouds and so on. Buildings contribute to protection against inhalation. The reason forthis is that the air outside and inside the dwelling is changed relatively slowly. How much of the pollutionthat enter the indoor air and how long time it takes is important information to determine if thepopulation is sufficiently protected inside buildings or if evacuation is needed. In this work knowledgefrom existing literature and modelling has been used to describe general conditions with which apollutant moves in and out of a building. Differential equations with main processes and parameters havebeen studied to give a estimation as to the protection a building can provide against ...
ECHA guidance recommends that a factor of 2 be applied when doing route to route extrapolation for oral to inhalation exposure; this has been included in this case due to a lack of data or the percentage of oral absorption. Therefore a factor of 2 was applied. Allometric scaling is applied by taking account for the different breathing rates between rats and humans, as described in ECHA technical guidance the oral NOAEL in the rat mg/kg/day *1/0.38 * 6.7/10 = mg/m3 inhalation NOAEC for workers. An additional adjust was made as recommended in ECHA guidance R8.4.3. The oral exposure for the rats was 7 days a week but inhalation exposure of workers is considered to be 5 days a week. This is adjusted by dividing the NOEC by 5/7 or 0.714286. ...
Felix, Human infection with hanta-virus occurs through inhalation of infected material, so as long as you werent breathing, or picking your nose when you were around the moose droopings, youll be OK, other-wise, head for the nearest epidemiologist. ,Al ...
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm ...
PRN: RIFM Innovative Model Calculates Inhalation Exposure To Fragrance Materials. RIFM Innovative Model Calculates Inhalation Exposure To Fragrance Materials [03-May-2012] - RIFM 2-Box Indoor Air Dispersion Model Is An Alternative Method To Calculate Inhalation Exposure To Fragrance WOODCLIFF LAKE, New Jersey, May 3, 2012 /PRNewswire/ --The Research Institute for Fragrance Materials, Inc. (RIFM) is beta testing its innovative 2-Box Indoor Air Dispersion Model software, an alternative method for assessing inhalation exposure to fragrance materials. RIFM Database subscribers can download the model for individual use by selecting Tools and Models from the RIFM Database home page and then selecting the model for download.
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alpha-blocker terazosin is also used. Each participant completes four study sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at 300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure); 2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that DE exposure will be associated with increased blood pressure, decreased brachial artery diameter, and increased circulating endothelins, and that these effects will be attenuated by terazosin administration ...
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alpha-blocker terazosin is also used. Each participant completes four study sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at 300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure); 2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that DE exposure will be associated with increased blood pressure, decreased brachial artery diameter, and increased circulating endothelins, and that these effects will be attenuated by terazosin administration ...
Environ Health Perspect: 11/22/13. Background: Diesel engine exhaust (DEE) has recently been classified as a known human carcinogen.. Objective: To derive a meta-exposure-response curve (ERC) for DEE and lung cancer mortality and estimate lifetime excess risks (ELRs) of lung cancer mortality based on assumed occupational and environmental exposure scenarios.. Methods: We conducted a meta-regression of lung cancer mortality and cumulative exposure to elemental carbon (EC), a proxy measure of DEE, based on relative risk (RR) estimates reported by three large occupational cohort studies (including two studies of workers in the trucking industry and one study of miners). Based on the derived risk function, we calculated ELRs for several lifetime occupational and environmental exposure scenarios, and also calculated the fractions of annual lung cancer deaths attributable to DEE. Read more. ...
TY - JOUR. T1 - A training exercise in subjectively estimating inhalation exposures. AU - Semple, Sean. AU - Proud, L. A.. AU - Tindall, M. E.. AU - Tannahill, S. N.. AU - Cherrie, John. PY - 2001. Y1 - 2001. N2 - Objectives This study examined whether it is possible to train occupational hygienists to estimate inhalation exposures reliably from limited occupational information using a new method and assessed improvements in the quality of the estimate using the aggregate from multiple assessors.Methods Five occupational hygienists estimated inhalation exposure for 40 tasks covering a range of chemical hazards using a recently developed subjective modeling technique supplemented by detailed guidance notes. The measured exposure levels were used to determine the validity of the method. The correlation coefficients of the log-transformed data were used to assess the discriminative power of the method, and the ratio of the mean estimate to measured values was used to measure accuracy.Results There ...
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Background: Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. Here we investigated whether diesel exhaust (DE) would induce apoptosis or proliferation in the bronchial epithelium in vivo and thus contribute to respiratory symptoms.. Methods: Moderate (n = 16) and mild (n = 16) asthmatics, atopic non-asthmatic controls (rhinitics) (n = 13) and healthy controls (n = 21) were exposed to filtered air or DE (100 μg/m 3 ) for 2 h, on two separate occasions. Bronchial biopsies were taken 18 h post-exposure and immunohistochemically analysed for pro-apoptotic and anti-apoptotic proteins (Bad, Bak, p85 PARP, Fas, Bcl-2) and a marker of proliferation (Ki67). Positive staining was assessed within the epithelium using computerized image analysis.. Results: No evidence of epithelial apoptosis or proliferation was observed in healthy, allergic or ...
The Organisation for Economic Cooperation and Development (OECD) announced the release of 17 new, updated, corrected or deleted Test Guidelines. The Test Guidelines include three that are specifically developed for nanomaterials.. A full list of publications in the Series on the Safety of Manufactured Nanomaterials is available on the OECD WPMN website via http://www.oecd.org/env/ehs/nanosafety/publications-series-safety-manufactured-nanomaterials.htm. (1) Test No. 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media (PDF, 1.5 MB). This document offers guidelines on a test procedure to gain information on dispersion stability of manufactured nanomaterials in simulated environmental media. It allows the users to understand the nanomaterials fate in natural waters and their potential behaviour in test media.. (2) Test No. 412: 28 days (Subacute) Inhalation Toxicity Study (PDF, 354 KB). (3) Test No. 413: Subchronic Inhalation Toxicity: 90-day Study (PDF, 354 KB). Both ...
Video articles in JoVE about inhalation exposure include Whole-Body Nanoparticle Aerosol Inhalation Exposures, Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System, A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii, Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping, The Lambda Select cII Mutation Detection System, An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei, Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry, Direct Tracheal Instillation of Solutes into Mouse Lung, Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination.
A colorless gas with a sharp, pungent odor. Fumes strongly in moist air. Nonflammable. Corrosive to metals and tissues and irritating to the eyes and respiratory system. Heavier than air. Long-term inhalation of low concentrations or short-term inhalation of high concentrations has adverse health effects. Prolonged exposure to fire or intense heat may result in the violent rupture and rocketing of the container. Used in the manufacture of rubber, pharmaceuticals, chemicals, and in gasoline refining and metals processing.. Rate of onset: Immediate. Persistence: Minutes to hours. Odor threshold: 0.77 ppm. Source/use/other hazard: Ore, other metal refining/cleaning; food/pickling; petroleum; corrosive liq.. ...
The information was provided to the workers from the year of introduction of diesel equipment at each facility , a surrogate for diesel exhaust exposure, from a variety of sources, including a 1998-2001 survey of diesel exhaust exposure at each facility, data from the U.S. Mine Safety and Health Administration Mine Information data Analysis system compliance database, data on diesel equipment usage over time and historical data at each facility mine ventilation... Its really no secret to deal with the sleep deprivation with a new baby with a new baby after Reynolds practicing Nurture try a healthy diet, and not on any additional take on tasks outside the home - you won t have time for them and nap when stay stay. Calm with a dramatic change in the life and routine, it can be difficult to stay cool and collected, but thats the key your baby your baby on an even keel. Even if something is wrong, reflects your mood and response to[ their] disposition. Are are freaking out, they do not ...
Background: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease including hypertension. PM inhalation causes several adv ...
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically results from inhalational exposures in individuals who work in industrial settings. The first known disease of inherited Mn excess, identified in 2012, is caused by mutations in the metal exporter SLC30A10 and is characterized by Mn excess, dystonia, cirrhosis, and polycythemia. To investigate the role of SLC30A10 in Mn homeostasis, we first generated whole-body Slc30a10-deficient mice, which developed severe Mn excess and impaired systemic and biliary Mn excretion. Slc30a10 localized to canalicular membranes of hepatocytes, but mice with liver Slc30a10 deficiency developed minimal Mn excess despite impaired biliary Mn excretion. Slc30a10 also localized to the apical membrane of enterocytes, but mice with Slc30a10 deficiency in small intestines developed minimal Mn excess despite impaired Mn export into the lumen of the small intestines. Finally, mice with Slc30a10 deficiency in liver and small intestines ...
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically results from inhalational exposures in individuals who work in industrial settings. The first known disease of inherited Mn excess, identified in 2012, is caused by mutations in the metal exporter SLC30A10 and is characterized by Mn excess, dystonia, cirrhosis, and polycythemia. To investigate the role of SLC30A10 in Mn homeostasis, we first generated whole-body Slc30a10-deficient mice, which developed severe Mn excess and impaired systemic and biliary Mn excretion. Slc30a10 localized to canalicular membranes of hepatocytes, but mice with liver Slc30a10 deficiency developed minimal Mn excess despite impaired biliary Mn excretion. Slc30a10 also localized to the apical membrane of enterocytes, but mice with Slc30a10 deficiency in small intestines developed minimal Mn excess despite impaired Mn export into the lumen of the small intestines. Finally, mice with Slc30a10 deficiency in liver and small intestines ...
Disclaimer: These masks should not be used (1) in any surgical setting or where significant exposure to liquid, bodily, or other hazardous fluids, may be expected; (2) in a clinical setting where the infection risk level through inhalation exposure is high; or (3) in the presence of a high intensity heat source or flammable gas. Wear Boise LLC makes no warranties, either express or implied, that the face cover prevents infection or the transmission of viruses or diseases ...
(Non Medical) Disclaimer: The mask should not be used (1) in any surgical setting or where significant exposure to liquid, bodily or other hazardous fluids, may be expected; (2) in a clinical setting where the infection risk level through inhalation exposure is high; or (3) in the presence of a high intensity heat sour
(Non Medical) Disclaimer: The mask should not be used (1) in any surgical setting or where significant exposure to liquid, bodily or other hazardous fluids, may be expected; (2) in a clinical setting where the infection risk level through inhalation exposure is high; or (3) in the presence of a high intensity heat sour
Buy Novidat Online! Novidat is used to treat bacterial infections in many different parts of the body. It works by killing bacteria or preventing their growth. Novidat oral liquid and tablets are also used to treat anthrax infection after inhalational exposure.
Buy Ciproxina Online! Ciproxina is used to treat bacterial infections in many different parts of the body. It is not effective against syphilis infections. Ciproxina oral liquid and tablets are also used to treat anthrax infection after inhalational exposure.
Cloth face coverings are not intended for use in the diagnosis of a disease or other conditions or in the cure, mitigation, treatment, or prevention of disease or for any other medical purposes. Avoid using these cloth face coverings (1) in any surgical or medical setting or where significant exposure to liquid, bodily, or other hazardous fluids may be expected; (2) in a clinical setting where the infection risk levels through inhalation exposure is high; or (3) in the presence of a high-intensity heat source or flammable gas ...
The breathing system comprises a canister carrying layered filtering material, including activated carbon granules, a dessicant, a catalyst for the catalyzation of carbon monoxide to carbon dioxide, optionally lithium peroxide, for conversion of CO2 to O2, and electrostatically charged filters between the layers of filtering material. A mouthpiece carrying a noseclip, and inhalation and exhalation check valves and a whistle is disposed within a flexible, substantially completely transparent hear-through hood, both the mouthpiece and hood being disposed in the canister between the filtering material and a cover for the canister. In use, the cover is removed, air inlet apertures are uncovered, and the hood is drawn about an individuals head and substantially sealed about the neck. With the mouthpiece in the individuals mouth, and noseclip closing off the users nose, inhalation causes air to flow through the filtering material and the inhalation check valve and past the exhalation check valves. When
A rodent model for microplastic ingestion inducing a gut response and modification similar to that of type II diabetes. Exposure to non-biodegradable pollutants such as BPA can have many adverse health effects on humans, including diabetes and insulin resistance. However, there is less research on the human health effects of microplastic exposure. Microplastics are a unique contaminant suite that humans are exposed to on a regular basis through inhalation or ingestion exposure pathways. For instance, microplastic exposure can arise from the consumption of seafood, as microplastics bio-accumulate in marine organisms such as fish or bivalves. Research conducted in complementary fields have illustrated the potential for microplastics to impact intestinal permeability and microbiome composition. Additionally, research in type 2diabetes and metabolic diseases have reported a reduced permeability of the intestinal tract. We plan to use a lab-controlled study of mice to study a diabetic-induced control ...
1. Locate a current SDS for one of the fixatives described in todays lab. Identify the properties and hazards associated with that chemical. Methanol that is used in Precipitation fixation Dangerous Good Class: 3 (Flammable liquid) Subsidiary Risk(s): 6.1 (Toxic) Risk: - Highly flammable. - Toxic by inhalation, in contact with skin and if swallowed. - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Safety Phrases: - Keep container tightly closed. - Keep away from sources of ignition - No smoking. - Avoid contact with skin. - Wear suitable protective clothing and gloves. - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). ...
1. The activities or operations where the workers are exposed to the chemical agents shall be considered unhealthy when the tolerance limits in Table 1 of this Annex are exceeded.. 2. All values given in Table 1 (Table of Tolerance Limits) are only for the absorption through inhalation.. 3. All values given in Table 1 as simple asphyxiant determine that, in the presence of these substances in the work environment, the minimum concentration of oxygen must be 18% by volume. The activities and operations in which the oxygen concentration is below, this value shall be considered as an imminent and serious risk.. 4. The chemical agents whose tolerance limits cannot be exceeded at any time during the working day are marked in the Ceiling Limit column.. 5. The chemical agents that can be absorbed through the skin and therefore requiring the use of gloves while handling, in addition to necessary PPE for protection of other body parts, are shown in the Absorption through skin column.. 6. The ...
Darkened lips can result from months and years of smoking. Nicotine and tar transfer to the lips through inhalation of the cigarette smoke, causing...
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سلامت کار ایران Iran Occupational Health (IOH) seeks to publish Original Research Papers and Case Reports, Review Articles and Technical Reports related to the fields of Public Health and Occupational Health particularly. IOH is an official publication of Iran University of Medical Sciences, Faculty of Public Health and is published quarterly. The following guidelines refer to the Journal requirements for receiving your manuscripts for possible publication. Complying with guidelines will expedite the process of evaluation and publication of the submitted manuscripts. IOH regrets to reject those contributions that deviate from the Journal style.
Acutely toxic chemicals may cause harm if it enters the body. They may enter the body in different ways: the most common is through inhalation (breathing it into the lungs) or through skin contact or ingestion.
Viral fever is a condition where viral infections are associated with the elevations of body temperature. These viruses enter the body through inhalation, direct contact, vectors, and contaminated water and food. These viral infections are easily contracted in person with low immune status. It affects all age groups but infants and old age people are more vulnerable.. ...
Question by Amit Varma. In the book The World of _____ by Bennett Alan Weinberg and Bonnie K Bealer, there is a photograph of a label from a jar of pharmaceutical-grade crystals. It reads:. WARNING: MAY BE HARMFUL IF INHALED OR SWALLOWED. HAS CAUSED MUTAGENIC AND REPRODUCTIVE EFFECTS IN LABORATORY ANIMALS. INHALATION CAUSES RAPID HEART RATE, EXCITEMENT, DIZZINESS, PAIN, COLLAPSE, HYPOTENSION, FEVER, SHORTNESS OF BREATH. MAY CAUSE HEADACHE, INSOMNIA, VOMITING, STOMACH PAIN, COLLAPSE AND CONVULSIONS.. Fill in the blank.. ...
A new long-term study by the National Cancer Institute and the National Institute for Occupational Safety and Health found that miners exposed to diesel engine exhaust are three times more likely to contract fatal lung cancer, and that commuters on busy highways in smoggy, urban areas might face a similar risk ...
Brands: STELLAR Telemetry sets new standards in wireless animal physiology monitoring where the animal can move anytime, anywhere and still record your data gap-free and loss-less using the latest technology. TSE DACO is a comprehensive software solution for inhalation exposure studies. The Daco software package allows unparalleled flexibility in experimental design and data recording. The flexibility is reflected in the control of the experimental setup, allowing a mix of different exposure systems, all the way through the analysis parameters and even offers an advanced software version with implementation of specific GLP checkpoints and audit trails termed Daco-GLP.. ...
Researchers are now adding additional data to the obesity puzzle, citing that diesel exhaust exposure while in utero could also be to blame for the rise in
The 3M™ Inhalation Valve 6893/07144 (AAD), Respiratory Protection Replacement Part works with the 3M™ Full and Half Facepiece Respirators 6000 Series (sold separately). Using this replacement part can extend the service life of respiratory protection equiment.
HSE has highlighted the importance of managing health risks effectively after a Gateshead company admitted exposing its workers to hazardous soldering fumes. View press release
In the aftermath of the large spill of crude 4-methylcyclohexylmethanol (MCHM) into the Elk River in 2014, there were reports of a strong licorice-smelling odor and reports of respiratory illness/cough suggestive of chemical-induced adverse airway effects. Levels of MCHM in the air were predicted to be as high as 0.39 ppm after 10 minutes of showering, suggesting that inhalation of MCHM vapors was a potential route of chemical exposure. NTP conducted prenatal developmental toxicity and 5-day toxicogenomic oral gavage studies that showed minimal MCHM-induced adverse effects; however, no in vivo inhalation studies for MCHM have been performed to date. In this study, we utilized an organotypic human air-liquid interface (ALI) culture model (EpiAirwayTM) derived from a single donor to determine if there was any potential for MCHM-induced airway toxicity in vitro following acute exposure to MCHM vapors for 6 hours, which might warrant future inhalation toxicity testing in vivo. ALI tissues were ...
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This presentation will address some of the obstacles with studies in juvenile animals related to specialty endpoints or routes of delivery as well as approaches to overcome them. Discussion topics include cardiovascular assessment, immunophenotyping, and T-cell dependent antibody response (TDAR) evaluation in juvenile dogs, and approaches to inhalation exposure of neonatal/juvenile rodents, and dogs.. ...
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