Abstract:. Traditional administration of rituximab requires careful titration and may involve many hours to minimize the risk of reactions. The objective of this study was to evaluate the safety of rapid infusions of rituximab in a pilot group of children with hematologic, oncologic, and rheumatologic disorders, and to determine the incidence of rate-related infusion reactions. Twenty patients enrolled in the study. All patients tolerated the rapid infusion of rituximab and no patient had an infusion-related reaction. We conclude that rapid infusions of rituximab are well tolerated and safe in our pilot group of patients.. ...
Weeks 1-24: Bevacizumab 5 mg/kg was administered as an intravenous infusion over 30 - 90 minutes followed by oxaliplatin, administered as an 85 mg/m^2 intravenous infusion over 2 hours (on day 1 only) concomitantly with leucovorin, as a 200 mg/m^2 infusion over 2 hours, followed by 5-FU, given as a 400 mg/m^2 bolus injection, and then as a 600 mg/m^2 continuous infusion over 22 hours. Leucovorin 200 mg/m^2 (alone), followed by 5-FU 400 mg/m^2 bolus injection, and 5-FU 600 mg/m^2 continuous infusion are repeated on day 2. Cycle length is 2 weeks and cycles were repeated every second week for a total of 12 cycles (24 weeks).. Weeks 25-48: Bevacizumab 7.5 mg/kg was administered as an intravenous infusion over 30 minutes. Cycle length was 3 weeks. Cycles were repeated every 3 weeks for a total of 8 cycles (24 weeks).. ...
J Antimicrob Chemother. 2012 Jan;67(1):17-24. doi: 10.1093/jac/dkr442. Epub 2011 Oct 25. Meta-Analysis; Research Support, Non-U.S. Govt; Review
The total dose chosen for this protocol is 28 mg/kg divided in two doses (14 mg/kg on days -7 and +3). Initial infusion: Start rate of 50 mg/hour; if there is no reaction, increase the rate by 50 mg/hour increments every 30 minutes, to a maximum rate of 400 mg/hour. Subsequent infusions: If patient did not tolerate initial infusion follow initial infusion guidelines. If patient tolerated initial infusion, start at 100 mg/hour; if there is no reaction, increase the rate by 100 mg/hour increments every 30 minutes, to a maximum rate of 400 mg/hour. Note: If a reaction occurs, slow or stop the infusion. If the reaction abates, restart infusion at 50% of the previous rate.. In patients who tolerated the Rituximab well in the past, a rapid infusion rate can be used over 90 minutes with 20% of the dose administered in the first 30 minutes and the remaining 80% is given over 60 minutes. ...
Study 3 was a multicenter, open-label trial that randomized (1:1) patients with mCRC who were previously untreated in the metastatic setting and who had received no prior oxaliplatin to receive Panitumumab every 14 days in combination with FOLFOX or to FOLFOX alone every 14 days. Panitumumab was administered at 6 mg/kg over 60 minutes prior to administration of chemotherapy. The FOLFOX regimen consisted of oxaliplatin 85 mg per m2 IV infusion over 120 minutes and leucovorin (dl-racemic) 200 mg per m2 intravenous infusion over 120 minutes at the same time on day 1 using a Y-line, followed on day 1 by 5-FU 400 mg per m2 intravenous bolus. The 5FU bolus was followed by a continuous infusion of 5-FU 600 mg per m2 over 22 hours. On day 2, patients received leucovorin 200 mg per m2 followed by the bolus dose (400 mg per m2) and continuous infusion of 5FU (600 mg per m2) over 22 hours. Study 3 excluded patients with known central nervous system metastases, clinically significant cardiac disease, ...
COMPLY thrombolytic strategy: Complement was effectively inhibited to 4 hours in the bolus arm and at 24 hours in the bolus plus infusion arm. There was no difference in infarct size as measured by the CKMB area under the curves at 72 hours between the 3 arms (p=0.85 for the placebo vs bolus comparison; p=0.81 for the placebo vs bolus+infusion comparison). There was no difference in the 90-day composite event rate between the 3 arms (18.6% placebo vs 18.4% bolus vs 19.7% bolus+infusion, p=0.84). COMMA PCI strategy: Complement was effectively inhibited to 4 hours in the bolus arm and at to 24 hours in the bolus plus infusion arm. There was no difference in infarct size as measured by the CKMB area under the curves at 72 hours between the 3 arms (p=0.89 for the placebo vs bolus comparison; p=0.76 for the placebo vs bolus+infusion comparison). There was no difference in the 90-day composite event rate between the 3 arms (11.1% placebo vs 10.7% bolus vs 8.4% bolus+infusion, p=0.39). Mortality at ...
Comparison of the plasma pharmacokinetic parameters following the 1st and 5th daily doses of 500 mg intravenous azithromycin showed only an 8% increase in Cmax but a 61% increase in AUC24 reflecting a threefold rise in C24 trough levels.. Following single-oral doses of 500 mg azithromycin (two 250 mg capsules) to 12 healthy volunteers, Cmax, trough level, and AUC24 were reported to be 0.41 mcg/mL, 0.05 mcg/mL, and 2.6 mcg∙h/mL, respectively. These oral values are approximately 38%, 83%, and 52% of the values observed following a single 500-mg I.V. 3-hour infusion (Cmax: 1.08 mcg/mL, trough: 0.06 mcg/mL, and AUC24: 5.0 mcg∙h/mL). Thus, plasma concentrations are higher following the intravenous regimen throughout the 24-hour interval.. Distribution The serum protein binding of azithromycin is variable in the concentration range approximating human exposure, decreasing from 51% at 0.02 mcg/mL to 7% at 2 mcg/mL.. Tissue concentrations have not been obtained following intravenous infusions of ...
Intravenous or arterial tubing adapters or connectors or locks or caps or protectors - Heparin locks; Intermittent infusion sets. ...
For pre-eclampsia (high blood pressure in pregnancy), 3 grams of L-arginine has been taken by mouth daily, in addition to standard therapy, for three weeks. Three grams of L-arginine has been taken by mouth every six hours, or intravenously (10 grams every eight hours) if the L-arginine taken by mouth was not tolerated, from diagnosis until day 10 postpartum. A dose of 4 grams of L-arginine has been taken by mouth daily for 10-12 weeks. A single intravenous infusion of L-arginine (20 grams per 500 milliliters) has been used. Five consecutive single daily infusions of L-arginine (20 grams per 500 milliliters), followed by 4 grams of arginine taken by mouth daily for two weeks, have been used. A dosage of L-arginine (20 grams per 500 milliliters) has been infused over two hours for four consecutive days ...
In this trial, 30 assessable patients were initially entered onto the study and four partial responses were seen. Further accrual of 22 assessable patients was then accomplished to define better the response rate with smaller confidence intervals. The starting dose of Taxol was 170 mg/m2 (135 mg/m2 for patients with prior pelvic radiation) given as a 24-hour continuous intravenous infusion with courses repeated every 3 weeks. Dose escalations to 200 mg/m2 and deescalations to 110 mg/m2 were allowed based on adverse effects. Results: ...
The aim of the study was to investigate the feasibility of mobilizing Philadelphia chromosome negative (Ph-) blood stem cells (BSC) with intensive chemotherapy and lenograstim (G-CSF) in patients with CML in first chronic phase (CP1). During 1994-1999 12 centers included 37 patients ,56 years. All patients received 6 months IFN, stopping at median 36 (1-290) days prior to the mobilization chemotherapy. All received one cycle of daunorubicin 50 mg/m2 and 1 hour infusion on days 1-3, and cytarabine (ara-C) 200 mg/m2 24 hours i.v. infusion on days 1-7 (DA) followed by G-CSF 526 microg s.c. once daily from day 8 after the start of chemotherapy. Leukaphereses were initiated when the number of CD 34+ cells was ,5/microl blood. Patients mobilizing poorly could receive a 4-day cycle of chemotherapy with mitoxantrone 12 mg/m2/day and 1 hour i.v infusion, etoposide 100 mg/m2/day and 1 hour i.v. infusion and ara-C 1 g/m2/twice a day with 2 hours i.v infusion (MEA) or a second DA, followed by G-CSF 526 ...
Semantic Scholar extracted view of Continuous intravenous infusion in the rat, and the effect on the islets of Langerhans on the continuous infusion of glucose. by B KINASH et al.
Its main uses are in intensive care medicine (pneumonia, peritonitis), somediabetes-related foot infections, and empirical therapy in febrile neutropenia(e.g., after chemotherapy). The drug is administered intravenously every 6 or 8 hr, typically over 30 min. It may also be administered by continuous infusion over 4 hours. Prolonged infusions are thought to maximize the time serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.. ...
To my understanding the first three infusions are considered loading infusions. The fourth infusion and every infusion here on out will be spaced out every eight weeks and they are considered maintenance infusions. The colonoscopy would reveal progress or lack of. Luckily, it was good news. I will say however, Emily has a terrible cough and fever. I know its something she picked up while getting her infusion. As you will become aware of Remicade suppresses the immune system so I take her colds seriously. She is having a chest X-ray and CT scan done in the morning. I think she might have a possible URI or sinusitis ...
Reidy et al reported on the results of 1,077 patients who had received a total of 10,606 doses of bevacizumab over a period of 2 years between February 2004 and June 2006. 8,494 administered doses were at a dose of 5 mg/kg. No hypersensitivity reactions occurred in the first 202 patients who received 90, 60 then 30 minute infusion times. The rate was then modified to 30 minutes for all infusions with no hypersensitivity reactions. The following 2,311 doses were administered at a rate of 5 mg/kg over 10 minutes (0.5 mg/kg/min), six patients (1.6%) experienced minor clinical events consistent with hypersensitivity reactions that were not serious. The data from this trial strongly suggests that the current standard practice, as cited in the product information, of prolongation of the initial doses of bevacizumab to 90 and 60 minutes is unnecessary. This standardised rate of 0.5 mg/kg/min was safe, logical and became the adopted policy at their institution.r. Dohn et al commented on the feasibility ...
2920 Background: Based on the preclinical activity of Gemcitabine(Gem) and Imatinib mesylate(IM) in combination (R. Hwang et al, 2003), a phase I study of Gem+IM was developed to determine MTDs for both Gem and IM when administered in combination. The study also assessed Gem pharmacokinetics (PK) in the presence and absence of IM. Methods Consenting patients (pts) with refractory malignancy; intact intestinal absorption, measurable/evaluable disease, adequate hepatic, renal and hematologic function; ECOG PS 0-2 and survival time estimated , 3 months were eligible. Pts with marrow involvement, ,25% marrow irradiation, brain metastasis and marrow transplant were excluded. Pts were treated at 14 dose levels. Gem, administered by fixed dose rate infusion, 10 mg/m2/min, had an initial schedule of 600 mg/m2 d1,8,15 q28d. Dose was decreased due to toxicity to 450 mg/m2/d 3,10 q 21d and, subsequently, re-escalated over 11 dose levels to 1500 mg/m2 d 3,10 q21 days. IM dose started at 300 mg qd, was ...
An Open Label, Dose-Escalation Safety and Pharmacokinetic Study of AVE9633 Administered as a Single Agent by Intravenous Infusion on Day 1, Day 4 and Day 7 of a 4-Week Cycle in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia (AML ...
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Stephanie did ~60% of her injections in her legs (the remainder in her tummy) so it was natural for her to use her inner thighs for infusion sets, too. She has great absorption there and has never had a problem with those sites. She has also used her arms several times, and although the absorption is good, she has decided that the tube snaking through her sleeve and shirt can get in the way more often than with tummy and leg sites. She uses 6mm rapid infusion sets...I dont know if teflon cannulas are any more likely to be crimped in the legs or not...I guess its another one of those YMMV things! Betsy ---------------------------------------------------------- for HELP or to subscribe/unsubscribe, contact: [email protected] send a DONATION http://www.Insulin-Pumpers.org/donate.shtml ...
This phase I study investigated the safety, tolerability and pharmacokinetics of WCK 771 800mg multiple-dose intravenous infusions in volunteers.
For patients who have developed an allergic reaction to Infliximab (Remicade), we now offer Remicade desensitization in conjunction with the Allergy and Immunology department. This is a technique which helps patients gradually adjust to Remicade and overcome their allergic reaction in order to preserve the use of this drug.. Saturday infusions are available at the Infusion Center on the BWH Main Campus, 75 Francis Street, Boston.. ...
An intravenous infusion rate is affected by the IV cannula gauge, the location of the IV cannula, the condition of the persons...
... are natural liquid solutions that promote healing and detoxify the liver. Our infusions include coffee, herbal, probiotic and apple cider vinegar.
Pedagogy Infusion Campus offers online infusion continuing education (CE) courses for nurses, RNs, LPNs, and LVNs on the topics of infusion practices, infusion therapy, and IV certification.
Pedagogy Infusion Campus offers online infusion continuing education (CE) courses for nurses, RNs, LPNs, and LVNs on the topics of infusion practices, infusion therapy, and IV certification.
The Portland Protocol Titration Guidelines© are listed below. Insulin infusion may be titrated between 0-30 U/H using these guidelines to rapidly (within 3 h) achieve and maintain blood glucose i... more
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1. Tampering, or attempting to tamper, in order to alter the integrity and validity of Samples collected during Doping Control is prohibited. These include but are not limited to catheterisation, urine substitution and/or adulteration (e.g. proteases). 2. Intravenous infusions are prohibited except for those legitimately received in the course of hospital admissions or clinical investigations. 3. Sequential withdrawal, manipulation and reinfusion of whole blood into the ...
York General Infusion Services are available for the convenience of patients who require intravenous (IV) infusions of medications or related services. These are provided within the department or after hours in the inpatient area of the Hospital. These services are ordered by medical providers and are designed especially to meet the needs of patients with:. ...
How to Make an Overnight Infusion. Herbal infusions bring substantial doses of nourishing herbs to you, providing minerals and nourishment that cannot be obtained from herbs in capsules or teas. An infusion is much stronger, and can be...
After speaking again with Nancy Klimas yesterday we decided to try saline infusions 2x a week to see if it helps me feel better. I just scheduled some...
Is Infusion Related Reaction a common side effect of Solupred? View Infusion Related Reaction Solupred side effect risks. Male, 49 years of age, was diagnosed with crohns disease and took Solupred 15 Mg Per Day 3 Days Before Cycle.
I had the same regimen you did but mine included a Neulasta shot the day after every infusion and my numbers were OK. I know a lady when her numbers dropped too low she had to come in for a transfusion once or twice. I also saw an elderly lady have her infusion rescheduled one day as her numbers were totally out of whack ...
He seems to be doing a bit better. His face, hands, and neck have flared less today. He was in better spirits for longer than usual which is encouraging. I am not being negative and say it is not going to last but I just hope in the next couple days it continues. There is no improvement in his weakness but I think that will not return for awhile. He is demanding and wants it his way. It is rather comical because he is so precious. However, I have been trying not to let him run the show too much. The bright side as well is that he will be returning once a week to the infusion center for keep the predisone up in his body and the IVIG. I am already mentally preparing that some of these infusions might just involve staying the night for monitering. I hope not but we need to do what we need to do. If that means staying then so be it. I am confident though that the once a week infusion will get us to where we need to be. The doctors lowered is at home persidone dose because of the weekly infusions. ...
... (alemtuzumab) - IV infusion given over the course of 5 consecutive days, followed 1 year later with a 3 day consecutive course
... (alemtuzumab) - IV infusion given over the course of 5 consecutive days, followed 1 year later with a 3 day consecutive course
I am sitting in my chair having my infusion as we speak. 15 more minutes to go and then an hour to wait after. So far so good. Will post later today when I get home. CF
Includes:10 all-in-one Cleo 90 infusion setsInstructionsFeatures:All-in-one design - The canister houses both an inserter needle and a cannulaNeedle
Did go out to the ranch for a week and had some fun out there but every morning I got up bent over just barely able to walk after a couple of hours I was able to walk around like most people. Every time I would sit for a while I had to do the same routine of trying to walk normal ...
Seems like no one understands!!! I"m sorry, and your not alone. Part of me says I wish this pain on no one, but the other part of me says, "if just for one day, or week or even one hour I felt what I do...!". I wish this with drs so.... ...
Hello Everyone! Just posting to let you all know I will be receiving my first Ocrevus infusion this Thursday. Im a little nervous since Im not entirely sure what I am in for, but hopefully everything will be okay. I was unhappy to learn that the 5 hour process will take 6 hours according to the infusion center rep. Being as I am bed-bound I cant imagine what it will be like if I dont have a place to lay down. No way I can sit in a recliner the entire time. The woman I spoke to by
MetaFilter is a weblog that anyone can contribute a link or a comment to. A typical weblog is one person posting their thoughts on the unique things they find on the web. This website exists to break down the barriers between people, to extend a weblog beyond just one person, and to foster discussion among its members.. ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
A rapid infusion system for the intravenous delivery of fluids at standard and rapid flow rates. The system includes a pump assembly, a drive assembly to power the pump, and a fluid containment system that keeps the infused fluid out of direct contact with the pump assembly and that is preferably disposable and removable. In one embodiment the drive assembly includes a differential drive that interacts with more than one motor. In one embodiment, the pump assembly includes a roller pump and the pump chamber is a collapsible, preformed tube that is preferably attached to a pump cartridge frame. Optionally, the system includes a self-leveling drip chamber and the fluid containment system is disposable and includes a pump cartridge containing the drip chamber and the pump chamber, I.V. tubing, outlet infusion tubing, and a heater cartridge.
Abstract Thirty-six patients with American cutaneous leishmaniasis were randomized to receive intravenous sodium stibogluconate for 10 days at a dose of 600 mg antimony (Sb) per day by one of three schedules: once daily by rapid infusion (A), by continuous 24 hr infusion (B), or in divided doses every eight hours by rapid infusion (C). Patients not cured after initial treatment were rerandomized to one of the other treatment schedules. An additional 19 patients who were not part of the randomized study received standard (STD) sodium stibogluconate treatment (600 mg Sb once daily by rapid infusion for 10 days, identical with schedule A). In the randomized study, the overall cure rate after the first course of treatment was 64%, but was higher for schedule A (100%) than for B (50%) or C (42%) (P < 0.01). Considering all courses of treatment, schedule A was more effective (94%) than B (53%) or C (43%) (P < 0.01). Paradoxically, patients in group A had a higher cure rate than patients in group STD (42
Metabolic acidosis is a prominent component of DKA. Patients with HHS have minimal or no acidosis. Insulin is used to stop ketoacid production; IV fluid alone has no impact on parameters of ketoacidosis (34). Short-acting insulin (0.1 U/kg/h) is recommended (35-37). Although the use of an initial bolus of IV insulin is recommended in some reviews (6), there has been only 1 randomized controlled trial (RCT) in adults examining the effectiveness of this step (38). In this study, there were 3 arms: a bolus arm (0.07 units/kg, then 0.07 units/kg/h), a low-dose infusion group (no bolus, 0.07 units/kg/h), and a double-dose infusion group (no bolus, 0.14 units/kg/h). Outcomes were identical in the 3 groups, except 5 of 12 patients needed extra insulin in the no-bolus/low-dose infusion group, and the double dose group had the lowest potassium (nadir of 3.7 mmol/L on average). Unfortunately, this study did not examine the standard dose of insulin in DKA (0.1 units/kg/h). In children, using an initial ...
We conducted a controlled, prospective trial to evaluate the effectiveness of rapidly infusing sodium bicarbonate (NaHCO3) and salt-poor albumin into high-risk, premature infants in the first 2 hours of life. Fifty-three infants, randomized into one of four treatment groups, received 8 ml. per kilogram of a solution containing either (A) glucose in water, (B) salt-poor albumin, (C) NaHCO3, or (D) a combination of albumin and NaHCO3. After the initial infusion, the babies received no colloid or alkali solutions until 4 hours of age. We managed them supportively with warmth, appropriate oxygen administration, isotonic fluid infusion, and close monitoring. Among the infants who received alkali, 14 of 26 acquired the respiratory distress syndrome (RDS), 11 died, and four had intracranial hemorrhage. Among babies who received no alkali, RDS occurred in 11 of 27, 5 died, and none had intracranial hemorrhage. These results do not support the common practice of rapidly infusing NaHCO3 into high-risk, ...
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patients (16 males, 7 females) with the mean (± SD) age of 41.22 ± 17.5. All patients received total dose of 72 mg throughout the test days, 9 of whom received 1 mg/h (continuous infusion) and the rest obtained 4 mg / 4 h (intermittent bolus doses). Blood samples were collected at 8 and 4 h prior to the end time of drug administration (zero time), zero time and 4, 8, 12, 20 and 30 h after it. APACHE (Acute Physiology and Chronic Health Evaluation) II required data was recorded daily and the patients mean score was 16.26 ± 4.38. The mean (± SD) value of pharmacokinetic parameters of Midazolam in continuous infusion
Animals were randomized into etomidate, CPMM, or vehicle groups (n = 8 rats per group). Throughout the experiment, rats were restrained in a 9-inch long, 3-inch diameter acrylic tube with ports for oxygen supplementation (100%, 2 l/min), arterial line access, and tail exit. To reduce the influence of diurnal variations in corticosterone concentrations, all experiments were begun at 8:30 am. After weighing and placement of a 24-gauge tail vein catheter for drug administration (performed with brief isoflurane anesthesia), rats were allowed to recover and acclimate to restriction for 2 h. Lipopolysaccharide (1 mg/kg) was then injected intravenously. Thirty minutes later, a 1-h intravenous infusion of etomidate, CPMM, or vehicle was started. To achieve and maintain equivalent hypnotic depths among the etomidate and CPMM groups, previously established continuous infusion protocols were used.20 These protocols were previously shown to maintain the electroencephalographic burst suppression ratio at 80% ...