Abstract. Secondary or reactive hemophagocytic syndrome (HPS) is frequently related to viral infections. However, the novel swine-origin influenza A (H1N1) virus associated HPS has never been reported. On October 10, 2009, a 17-year-old female child with no past medical history, complaining of severe asthenia, pneumonia, myalgia, and high fever, was admitted to our department, and H1N1 DNA was detected. Five days after her hospitalization, all signs and symptoms aggravated into HPS. After treatment for H1N1 influenza, the patient had a recovery and clearance of H1N1 infection 10 days after hospitalization. Three weeks later, the patient was discharged without any complaints, indicating the etiological role of H1N1infection in HPS.
In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1 ...
TY - JOUR. T1 - Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza a epidemic. AU - Smith, Gavin J D. AU - Vijaykrishna, Dhanasekaran. AU - Bahl, Justin. AU - Lycett, Samantha J.. AU - Worobey, Michael. AU - Pybus, Oliver G.. AU - Ma, Siu Kit. AU - Cheung, Chung Lam. AU - Raghwani, Jayna. AU - Bhatt, Samir. AU - Peiris, J. S Malik. AU - Guan, Yi. AU - Rambaut, Andrew. PY - 2009/6/25. Y1 - 2009/6/25. N2 - In March and early April 2009, a new swine-origin influenza A (HlNl) virus (S-OIV) emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread worldwide to 30 countries (as of May 11 ) by human-to-human transmission, causing the World Health Organization to raise its pandemic alert to level 5 of 6. This virus has the potential to develop into the first influenza pandemic of the twenty-first century. Here we use evolutionary analysis to estimate the timescale of the origins and the early development of the S-OIV epidemic. We show ...
This document provides interim guidance for state and local health departments, hospitals, and clinicians in regions with few or no reported cases of swine-origin influenza A (H1N1) (S-OIV) regarding which patients to evaluate for possible infection with swine influenza A (H1N1). As of April 29 1:00 PM, there were 91 laboratory confirmed cases of S-OIV infection identified in 14 states in the United States. Human cases of S-OIV infection also have been identified internationally. Based on the rapid spread of the S-OIV thus far, public health officials believe that more cases will be identified over the next several weeks, including in regions that currently have few or no reported cases ...
The Pandemic H1N1/09 virus is a swine origin Influenza A virus subtype H1N1 virus strain responsible for the 2009 flu pandemic. For other names see the Nomenclature section below. The virus is a novel strain of influenza. Existing vaccines against seasonal flu provided no protection. A study at the U.S. Centers for Disease Control and Prevention (CDC) published in May 2009 found that children had no preexisting immunity to the new strain but that adults, particularly those over 60, had some degree of immunity. Children showed no cross-reactive antibody reaction to the new strain, adults aged 18 to 64 had 6-9%, and older adults 33%. Much reporting of early analysis repeated that the strain contained genes from five different flu viruses: North American swine influenza, North American avian influenza, human influenza, and two swine influenza viruses typically found in Asia and Europe. Further analysis showed that several of the proteins of the virus are most similar to strains that caused mild ...
The recent swine origin influenza pandemic (2009), new emergence of swine origin H3N2v, and delayed availability of vaccine for these agents highlight the need to test and optimize public health intervention strategies to reduce transmission of influenza. We will use a new technology for biological particle collection (U.S. Provisional Patent Application No. 61/162,395, McDevitt et al., Aerosol Sci Technol 2013) to make fundamental observations on infectious respiratory droplets in a study of up to 200 naturally occurring seasonal influenza cases. We will collect respiratory droplets shed by participants while breathing normally, talking, and spontaneously coughing. We will characterize the size distribution of droplets containing infectious virus. We will use these basic data to examine the roles of large and small respiratory droplets and examine how the interaction of host factors and virus type impact the shedding of infectious respiratory droplets. Subjects will be recruited through a web ...
The use of monoclonal antibodies Fab28 and Fab49 for the prophylactic or therapeutic treatment of swine-origin influenza A (H1N1) virus (S-OIV) infections is described, the which virus is responsible for the influenza syndrome commonly known as
Vaccination Pandemrix suspension and emulsion for emulsion for injection. 1 dose (0.5 ml) contains Split influenza virus, inactivated, containing antigen 3.75 micrograms of A/California/7/2009 (H1N1)v-like strain (X-179A). * Pandemic influenza vaccine (H1N1)v (split virion, inactivated, adjuvanted) ...
Influenza A virus has been detected in the blood of some infected individuals, and may pose a safety concern for collection, handling and transport of specimens for epidemiological and public health investigations if infectious virus is present in samples. Furthermore the effect of storage on virus stability and infectivity has not been well studied. We examined the stability of novel pandemic influenza A (H1N1) virus RNA when the virus was stored in phosphate buffered saline (PBS), plasma, or buffy coated blood at either room temperature or 4°C using a sensitive Taqman RT-PCR assay. We also investigated virus infectivity using the EID50 assay when virus was stored in PBS, plasma, or buffy coats isolated from blood at 4°C. Viral RNA stability was affected by the matrix used for storage. The recovery of viral RNA was highest when virus was stored in PBS with lower amounts being recovered from plasma and buffy coats at either room temperature or 4°C. Incubation time did not appear to be a major factor
On April 24, 2009, CDC reported eight confirmed cases of swine-origin influenza A (H1N1) virus (S-OIV) infection in Texas and California.1 The strain ...
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin ...
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA (1). In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States (2). The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic (3). Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin ...
Feng-Cai Zhu, M.D Click here ., Hua Wang, M.D., Han-Hua Fang, M.D., Jian Guo Yang, M.D., Xiao Jun Lin, M.D., Xiao-Feng Liang, M.D., Xue-Feng Zhang, M.D., Hong-Xing Pan, M.D., Fan-Yue Meng, M.D., Yue Mei Hu, M.D., Wen-Dong Liu, M.D., Chang-Gui Li, M.D., Wei Li, M.D., Xiang Zhang, M.D., Mei Hu Jin, M.D., Wei Bing Peng, M.D., Bao Ping Yang, M.D., Pei Xi, M.D., Hua-Qing Wang, M.D., and Jing-Shan Zheng, M.D.: A Novel Influenza A Vaccine in a variety of Age Groups Recently, a novel swine-origin influenza A virus was defined as the cause of large numbers of febrile respiratory ailments in Mexico and the United States.1,2 It quickly spread to numerous countries around the world, prompting the World Health Company to declare a pandemic on June 11, 2009.3 An important technique of controlling this pandemic will be large-level immunization.. This getting contrasts with the constant observation of JC virus in urine in mere one third of people in cross-sectional studies10-13 and the observation that the ...
Prior research developed Reassortment Networks to reconstruct the evolution of segmented viruses under both reassortment and mutation. We report their appl
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Patient is a male in his 40s from Bannock County. Patient is recovering at home. Patient had contact with a confirmed case.. - Patient is a female, under the age of 18, from Bannock County. Patient is recovering at home. Patient had contact to a confirmed case. - Patient is a female, under the age of 18, from Bannock County. Patient is recovering at home. Case is considered community transmission.. - Patient is a female, under the age of 18, from Bear Lake County. Patient is recovering at home. Patient had contact to a confirmed case.. - Patient is a male in his 80s from Bingham County. Patient is recovering at home. Case is considered community transmission.. - Patient is a female, under the age of 18, from Bingham County. Patient is recovering at home. Case is considered community transmission.. - Patient is a female in her 30s from Bingham County. Patient is recovering at home. Case is considered community transmission.. - Patient is a female in her 60s from Bingham County. Case is considered ...
Original text: http://www.davidcayley.com/blog/2020/4/8/questions-about-the-current-pandemic-from-the-point-of-view-of-ivan-illich-1. Last week I began an essay on the current pandemic in which I tried to address what I take to be the central question that it raises: Is the massive and costly effort to contain and limit the harm that the virus will do the only choice we have? Is it no more than an obvious and unavoidable exercise of prudence undertaken to protect the most vulnerable? Or is it a disastrous effort to maintain control of what is obviously out of control, an effort which will compound the damage being done by the disease with new troubles that will reverberate far into the future? I hadnt been writing for long before I began to realize that many of the assumptions I was making were quite remote from those being expressed all around me. These assumptions had mainly come, I reflected, from my prolonged conversation with the work of Ivan Illich. What this suggested was that, before I ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The symptoms of swine flu are similar to normal flu and include fever, cough, sore throat, headache, aching limbs, chills and fatigue. Some patients infected with swine flu have also reported loss of appetite, diarrhoea and vomiting. In very young children, the warning signs include fast or troubled breathing, a bluish skin tone, a failure to interact with others, and being highly irritable. As with seasonal flu, swine flu varies in severity, with the worst cases leading to fatal pneumonia and respiratory failure. The new strain seems to be more lethal to those in the 25 to 45 age range. This was a hallmark of the Spanish 1918 flu pandemic that killed tens of millions worldwide. Younger people were probably hit harder than the elderly by the 1918 flu virus because their immune systems overreacted. ...
WHOs done it: Swine flu scam enters $600 billion phase! Responding to pharmaceuticals business emergency, WHO phinally declares swine flu phandemic Here are some of the issues to consider: 1. Swine flu is a phandemic; its a pandemic created by the World Health Organization (WHO), for pharmaceuticals. [See background, and scam details.] 2. The recent…
WASHINGTON - A substantial portion of elderly Americans may have some immunity to the swine-origin H1N1 influenza virus, a finding that may prove useful when and if a vaccine to the new flu strain becomes available. The questions of whom to target with a swine flu vaccine, and how to stretch the supply if it is limited, are among the most important issues facing public health officials over the next four months.
Source: AP. ATLANTA - Health officials are investigating a never-before-seen form of the flu that combines pig, bird and human viruses and which has infected seven people in California and Texas. All the victims recovered, but the cases are a growing medical mystery because its unclear how they caught the virus.. None of the seven people were in contact with pigs, which is how people usually catch swine flu. And only a few were in contact with each other, according to the U.S. Centers for Disease Control and Prevention.. Still, health officials said its not a cause for public alarm: The five in California and two in Texas have all recovered, and testing indicates some mainstream antiviral medications seem to work against the virus.. Dr. Anne Schuchat of the CDC said officials believe it can spread human-to-human, which is unusual for a swine flu virus.. The CDC is checking people who have been in contact with the seven confirmed cases, who all became ill between late March and ...
The last time the government embarked on a major vaccine campaign against a new swine flu, thousands filed claims contending they suffered side effects. This time, the government has already taken steps to head that off.
The best thing you can do to protect your children from swine flu (H1N1 virus) is to get them the seasonal flu vaccine. Each year, researchers determi
momof2little1s and her family Last summer, CafeMom momof2little1s personally endured a swine flu horror story at 34 weeks pregnant. Although, she and ...
Via the Globe and Mail, a report by Caroline Alphonso: Swine flu less severe than feared? Excerpt:The pandemic H1N1 influenza virus in Canada is not as severe as expected nor is it spreading quickly, the countrys top public health official...
So, news today that a new pandemic of swine flu is threatening the health and lives of the citizens of the world. The dictionary assures me that the word pandemic is an adjective which means: Widespread; general. Medicine Epidemic over a wide geographic area and affecting a large proportion of the population: pandemic influenza. Now, I…
At the beginning of the summer it looked as if we could be on the brink of a major health epidemic that could bring the country to its knees. A huge machine went to work preparing for the impending cataclysm. Six months later the swine flu epidemic has been a bit of a damp squib, and the medical profession looks as if it has been crying wolf yet again.. Millions of pounds were spent on vaccines and antivirals and a great deal of anxiety has been generated. So was this incompetence? And, are we going to point the finger of blame at someone?. The retrospectoscope is a great and wonderful tool. Looking back to the summer there was a very real threat of a new strain of a virus, which had the potential to spread rapidly across the world. Attempts at containment were unlikely to succeed. In addition, there was evidence from South America showing that this new virus had the potential to be highly virulent, and worst case scenarios suggested that up to 65,000 people could have died.. Those responsible ...
The likelihood of a third wave of pandemic H1N1 influenza appears to be declining as all indicators of swine flu activity remain low throughout the bulk of the country, according to data released
Swine flu cases continue appearing as the virus evolves, prompting a World Health Organization meeting to address decisions surrounding creation and distribution of a vaccine.
Children should be among the first people to be vaccinated against swine flu if health officials hope to temper the severity of the epidemic, a study published Thursday has found.
Health and Human Services Secretary Kathleen Sebelius appealed anew Wednesday for widespread inoculation against a surging swine flu threat, calling the vaccine
All this week weve been talking to CafeMoms about whether or not their family will receive the H1N1 vaccine to prevent the swine flu. AmyTuteurM...
Well after posting yestreday about definately not having it im now really really unsure. I cant believe they would let us have it but then the WHO dont agree with it so who do we believe? I cant help thinking I have come this far without getting Swine Flu that im due on 20th December so its only another 7 weeks to hold off until. Its the ladies earlier on that I feel sorry for having to make a bigger decision ...
More than half of Britons being offered vaccination against pandemic H1N1 flu are turning it down because they fear side-effects or think the virus is too mild to bother, a survey of doctors showed on Wednesday ...
A 56-year-old woman and a 50-year-old man died of swine flu here Monday - the first deaths in Orissa due to the pandemic H1N1 virus this year, a senior health official said. The woman from citys Sailashree Vihar area
Epidemiology has long provided jobs for statistical analysis jocks, and right now the big question in epidemiology is swine flu. How goes the war? The Centers for Disease Control began tracking the progress of the disease in April 2009, with the first laboratory-confirmed case of H1N1. At the beginning of November a public health blogger responded…
Will swine flu end up sweeping the globe in a flu pandemic? The Centers for Disease Control and Prevention announced this week that its taking some
The World Health Organization is firing back against accusations that its swine flu pandemic declaration was driven by drug makers hoping to cash in on vaccines.
In 2009 the world experienced a swine flu pandemic. Learn more about what happened and the current status of the H1N1 strain here.
As of 24 April 2020, the SARS-CoV-2 epidemic has resulted in over 830,000 confirmed infections in the United States1. The incidence of COVID-19, the disease associated with this new coronavirus, continues to rise. The epidemic threatens to overwhelm healthcare systems, and identifying those regions where the disease burden is likely to be high relative to the rest of the country is critical for enabling prudent and effective distribution of emergency medical care and public health resources. Globally, the risk of severe outcomes associated with COVID-19 has consistently been observed to increase with age2,3. We used age-specific mortality patterns in tandem with demographic data to map projections of the cumulative case burden of COVID-19 and the subsequent burden on healthcare resources. The analysis was performed at the county level across the United States, assuming a scenario in which 20% of the population of each county acquires infection. We identified counties that will probably be consistently,
Viruses do not do this -- they self-replicate by infecting a cell, making millions of copies of itself and then breaking free of the cell to go infect more. This means one "parent" makes millions of "offspring" which are identical to the parent. Not only that, but when the replicate themselves, they hijack the cells machinery for building RNA and proteins. Like an assembly line, all the different parts of the virus get made separately and then at the very end, everything gets packaged together into a new virus. (see below. Yellow = virus, red squiggles = RNA... remember that for later ...
A new study presents peer-reviewed cases of COVID-19 in order to ensure that the disease is diagnosed as rapidly as possible, and thus help prevent an overwhelming spike in infections in any one place during the course of the current pandemic. Much interest has been shown in the possibility of using chest X-rays, and computed tomography (CT) scans to screen for and diagnose patients with this illness, whether suspected or confirmed.. ...
The NHS Commissioning Board (NHSCB) has now authorised a second wave of clinical commissioning groups (CCGs) to commission healthcare services for their communities, taking the total to 101 groups serving more than 28 million people in England. - News - PharmaTimes
CIDRAP News) Testing by the US Centers for Disease Control and Prevention (CDC) has confirmed that the novel H3N2 viruses that recently sickened three Iowa children are similar to swine-origin viruses containing a gene segment from the 2009 H1N1 virus that have been identified in three other states. ...
Do you know what the flu consists of and how you can catch it? Whats the best way to treat and prevent it? Well tell you everything you need to know about
Balish, A., Garten, R., Klimov, A. and Villanueva, J. (2013), Analytical detection of influenza A(H3N2)v and other A variant viruses from the USA by rapid influenza diagnostic tests. Influenza and Other Respiratory Viruses, 7: 491-496. doi: 10.1111/irv.12017 ...
Please cite this paper as: Erkoreka A. (2010) The Spanish influenza pandemic in occidental Europe (1918-1920) and victim age. Influenza and Other Respiratory Viruses 4(2), 81-89.. Background Studies of the Spanish Influenza pandemic (1918-1920) provide interesting information that may improve our preparation for present and future influenza pandemic threats.. Methods We studied archives from France, Italy, Spain and Portugal, obtaining high-quality data that allowed us to calculate mortality rates associated with the Spanish flu and to characterize the proportional distribution of influenza deaths by age in the capital cities of these countries.. Results French and American troops who fought in the First World War began to be affected from April 1918 onwards by a benign influenza epidemic, which hardly caused any deaths. The first occidental European country in which the pandemic spread to large sectors of the population, causing serious mortality, was Spain. The associated influenza provoked in ...
We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable. Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the RIDT using NS specimens were evaluated against nasal swabs tested by real time reverse transcription polymerase chain reaction (rRT-PCR). The performance parameter results were expressed as 95% confidence intervals (CI) calculated using binomial exact methods, with P < 0.05 considered significant. Two-sample Z tests were used to test for differences in sample proportions. Analysis was performed using SAS software version 9.3. From July 2013 to July
On May 18, this report was posted as an MMWR Early Release on the MMWR website (http://www.cdc.gov/mmwr).. Since April 15 and 17, 2009, when the first two cases of novel influenza A (H1N1) infection were identified from two southern California counties, novel influenza A (H1N1) cases have been documented throughout the world, with most cases occurring in the United States and Mexico (1--3). In the United States, early reports of illnesses associated with novel influenza A (H1N1) infection indicated the disease might be similar in severity to seasonal influenza, with the majority of patients not requiring hospitalization and only rare deaths reported, generally in persons with underlying medical conditions (2,3). As of May 17, 2009, 553 novel influenza A (H1N1) cases, including 333 confirmed and 220 probable cases, had been reported in 32 of 61 local health jurisdictions in California. Of the 553 patients, 30 have been hospitalized. No fatal cases associated with novel influenza A (H1N1) ...