BACKGROUND: In recent trends, there is increasing number of babies born with very low birth weight. These VLBW babies are at risk of developing Hypoglycemia, Sepsis, Hyperbilirubinemia, Respiratory distress when compared to term babies. By studying the risk factors leading to very low birth weight and their morbidities, health professionals will be able to anticipate and manage them accordingly. Identification of morbidity and mortality in VLBW neonates will help us in formulating and implementing interventions to reduce neonatal mortality rate. AIM OF THE STUDY: To study the morbidity and mortality profile in very low birth weight neonates in Neonatal Intensive Care Unit in Coimbatore Medical College Hospital. OBJECTIVES: 1. To study the morbidity and mortality pattern in very low birth weight neonates. 2. To study the maternal risk factors leading to very low birth weight neonates. 3. To establish targeted preventive and advanced treatment strategies in specific areas. 4. To plan for future ...
TY - JOUR. T1 - A hearing screening in very low birth weight preterm infants by auditory brainstem response. AU - Wu, J. L.. AU - Huang, C. C.. AU - Kao, C. C.. PY - 1998. Y1 - 1998. N2 - Background: ABR has been used as an objective, non-invasive tool to screen neonatal deafness. In this article, we evaluated the prevalence of deafness in VLBW preterm newborns by ABR, and attempted to search for a suitable failed/passed criterion. Methods: ABR screening test was performed in 88 VLBW preterm newborns. The infants whose threshold was ≤ 35dB nHL were classified as Group A; those whose threshold was ≤ 25dB nHL were classified as Group B. All of the newborns of either Group A or Group B received the successive ABR screening test and behavioral audiometry to confirm whether they have hearing impairment or not. Results: Fourteen newborns (16%) were included in Group A and 19 newborns (22%) in Group B. There were five newborns who belonged to Group B, but not to Group A; all of them were found ...
MUDAHEMUKA, J C e BALLOT, D E. Birth weight recovery among very low birth weight infants surviving to discharge from Charlotte Maxeke Johannesburg Academic Hospital. S. Afr. j. child health [online]. 2014, vol.8, n.4, pp.149-153. ISSN 1999-7671. http://dx.doi.org/10.7196/SAJCH.709.. BACKGROUND: The recommended growth velocity (GV) of very low birth weight (VLBW) infants is 15 g/kg/day. Several factors have been associated with poor postnatal weight gain. OBJECTIVE: To provide current information on the postnatal growth of VLBW infants at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH). METHODS: This was a longitudinal study of VLBW infants surviving to discharge from CMJAH neonatal unit from August to October 2013. RESULTS: Sixty-nine infants were included in the study. The mean GV was 13.2 g/kg/day, the median weight loss was 7.69% and the median time for regaining birth weight was 16 days. Fifty-one infants (73.9%) regained their birth weight at or before 21 days. There was a decrease ...
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The purpose is to collect baseline and outcome data in a uniform manner on a large cohort of VLBW and other sick infants admitted to neonatal intensive care units.. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is generic). Baseline data is collected soon after admission to the NICU; outcome data is collected at the time of death or discharge from the hospital. The data collected includes information on:. ...
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The purpose is to collect baseline and outcome data in a uniform manner on a large cohort of VLBW and other sick infants admitted to neonatal intensive care units.. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is generic). Baseline data is collected soon after admission to the NICU; outcome data is collected at the time of death or discharge from the hospital. The data collected includes information on:. ...
A new method for direct measurement of airway pressure using a fiber optic pressure sensor (FOPS) has been tested in very low birth weight infants during mechanical ventilation. Airway pressure and ventilatory flow was recorded in an initial investig
Programs Calendar with Balancing the Nutritional Needs of Very Low Birth Weight Infants with the Protective Properties of Human Milk - June ...
Interventions for treatment of neonatal hyperglycemia in very low birth weight infants: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Very low birth weight infants (newborns who weigh less than 3 pounds 2 ounces) require intensive medical care. While these infants represent less than 2 percent of all live births, they also account for about two-thirds of the infants who die in the first year of life. Interventions that reduce the very low birth weight rate will also reduce Medicaid expenditures during the first year of life and reduce the infant mortality rate.. The integrated delivery of the WIC and FCM programs is having a significant impact on the states infant mortality rate and health care expenditures. Nine consecutive annual program evaluations have shown that the health status of infants born to Medicaid-eligible women who participated in both WIC and FCM has been substantially better than that of infants born to Medicaid-eligible women who did not participate in either program. In particular, the rate of premature birth is more than 60 percent lower among participants in both programs. The rate of low birth weight is ...
OBJECTIVE: The goal was to determine the effect of training in newborn care and resuscitation on 7-day (early) neonatal mortality rates for very low birth weight (VLBW) infants. The study was designed to test the hypothesis that these training programs would reduce neonatal mortality rates for VLBW infants.
BACKGROUND: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available ESAs. OBJECTIVES: To assess the effectiveness and safety of ESAs (erythropoietin (EPO) and/or Darbe) initiated early (before eight days after birth) compared with placebo or no intervention in reducing red blood cell (RBC) transfusions, adverse neurological outcomes, and feeding intolerance including necrotising enterocolitis (NEC) in preterm and/or low birth weight infants ...
BACKGROUND Infants less than 1500 grams at birth have been demonstrated to be particularly prone to development of low levels of serum sodium often leading to increased early neonatal morbidity and mortality. No local study has been done to quantify this problem among sick newborns. Studies elsewhere demonstrate a high incidence of hyponatraemia among such preterms. OBJECTIVE To evaluate the influence of infant early neonatal morbidity on serum sodium levels and justify regular monitoring and supplementation. DESIGN Comparative cohort study. SETTING Newborn Unit, Kenyatta National Hospital, Nairobi. SUBJECTS Fifty six very low birth weight (1000-1500 grams at birth) infants during their first week of life. Half of them were designated as cases in view of having various early neonatal illnesses. The remaining 28 being clinically stable were taken as controls. These two groups had comparable birthweights, sex distribution and gestational ages. Their sodium intakes were also similar during the
Dietary protein is needed for normal growth and development. The protein intake required for growth of the low birth weight infant has been estimated by the growth rate of the fetus to be 3.5 to 4.0 g/kg/d. Controlling the amount of protein given to low birth weight babies (less than 2.5 kg) fed with formula is important. Too much protein can raise blood urea and amino acid (phenylalanine) levels, and this may harm neurodevelopment. Too low protein intake may limit the growth of these infants. The review authors searched the medical literature to identify studies that compared protein intake as follows: between 3 and 4 g of protein per kg of infant body weight each day versus less than 3.0 g/kg/d or greater than 4.0 g/kg/d by low birth weight infants fed formula during their initial hospital stay. Increased protein intake resulted in greater weight gain of around 2.0 g/kg/d. Based on increased body incorporation of nitrogen, this was associated with increased lean body mass. The present conclusion was
Dietary protein is needed for normal growth and development. The protein intake required for growth of the low birth weight infant has been estimated by the growth rate of the fetus to be 3.5 to 4.0 g/kg/d. Controlling the amount of protein given to low birth weight babies (less than 2.5 kg) fed with formula is important. Too much protein can raise blood urea and amino acid (phenylalanine) levels, and this may harm neurodevelopment. Too low protein intake may limit the growth of these infants. The review authors searched the medical literature to identify studies that compared protein intake as follows: between 3 and 4 g of protein per kg of infant body weight each day versus less than 3.0 g/kg/d or greater than 4.0 g/kg/d by low birth weight infants fed formula during their initial hospital stay. Increased protein intake resulted in greater weight gain of around 2.0 g/kg/d. Based on increased body incorporation of nitrogen, this was associated with increased lean body mass. The present ...
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This report documents the temperature on admission of a recent large cohort of very low birth weight infants born within 15 academic centers and transferred directly to the NICU from the labor and delivery department. The principal findings of this study are as follows: (a) low temperatures on admission are common; (b) there are important associations between the admission temperature and variables antecedent to admission that may be amenable to change; and (c) there is a prominent association between the extent of reduced temperature on admission and both late-onset sepsis and in-hospital mortality.. Efforts to limit heat loss are important initial steps in the stabilization of newborns immediately after birth and are incorporated in the Neonatal Resuscitation Program12 and the World Health Organizations guide to thermal control of the newborn.13 Minimizing heat loss in low birth weight and premature infants is difficult because of high evaporative heat loss exacerbated by a large temperature ...
BACKGROUND: Preterm birth is associated with variable degrees of brain injury, adverse neurodevelopmental outcomes and continuing special health care needs. STUDY AND AIMS: This observational, retrospective and cross-sectional study aims to describe the functional features of VLBW infants using the ICF-CY classification and to identify the association between gender, twinship, birth weight, gestational age, adjusted age and functioning as defined by the ICF biopsychosocial model. SAMPLE: 56 VLBW infants (corrected age of 12-24 months) were consecutively enrolled. INSTRUMENTS: Three assessment tools were used: a neuro-functional assessment (NFA); the Griffiths Mental Development Scales-Revised: Birth to 2 years (Griffiths 0-2) to evaluate psychomotor development and the ICF-CY questionnaire for ages 0-3. RESULTS: A two-step cluster component analysis with the Bayesian information criterion was conducted based on NFA and Griffiths 0-2 scores and four groups of infants functioning (very low, low, ...
This study examined the patterns of cognitive development in a sample of VLBW children, many of whom had poorly educated mothers, placing them at risk for developmental delays on both biomedical and sociodemographic grounds. Five developmental patterns were identified by cluster analysis. The clusters were subjected to validation analyses and found to be sufficiently different from one another on the criterion variables to indicate good validity. Their developmental patterns indicated that throughout the first 6 years of life, 37% (clusters A and B) of the children performed consistently in the average range, 12% did consistently poorly (E), and 8% (D) showed a steady improvement. The largest group (43%) (C) declined from average to below average.. With one exception, all the independent variables examined were significantly associated with cluster membership. The exception was SGA. The absence of a relationship between SGA and outcome is probably attributable to the relatively limited birth ...
Results Forty-one infants for both groups were recruited. Neonatal and socio-demographic characteristics of both groups were similar except for the confounders caesarean section, antenatal corticosteroids (higher in AREDF group, p = 0.01 and 0.02, respectively), and mothers age (lower in AREDF group, p = 0.01). Mean (SD) mental development index of children with AREDF in the UA (81.8, 16.3) was significantly lower (p = 0.02) compared to controls (92.4, 16.3). This result remains significant after adjustment for confounders. No significant differences in the psychomotor development index or in the distribution of cerebral palsy were observed between the two groups.. ...
Results The mean i-FABP concentration in the second group (1.75±0.62 ng/ml) was elevated in 1.4 times compared with the first group (1.23±0.23 ng/ml). Significant high urine i-FABP concentration was observed in died infants of second group (2.39±0.88 ng/ml, p,0.05). In contrast the serum LBP level in newborns of second group was lower (23.1±4.5 ng/ml) in 1.4 time compared to newborns of first group (32.1±2.3 ng/ml).. ...
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Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping. ...
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Background: One of the most common methods of identifying mortality risk is the Clinical Risk Index for Babies scoring system (CRIB- II). The aim of this study was assessing the value of CRIB- II in predicting mortality risk in preterm and low birth weight infants in East Azerbaijan- Iran. Materials and Methods: This prospective cohort study was carried out in 2013-2014 during 6 months in NICUs of Alzahra, Taleqani and Children hospitals of Tabriz-Iran. All infants ≤ 32 weeks gestational age or ≤ 1500gr birth weight were included in the study using consecutive method. After calculating CRIB- II score, the infants were followed up at 3 months of age and their outcome was determined. The data was analyzed using SPSS-13, t- test, receiver operating characteristics (ROC) and area under curve (AUC) and relative risk (RR). Results: Of total 215 infants, 64 infants (29.7%) died in the hospital and one infant (0.4%) died after discharging from the hospital. 150 (68.8%) infants, were alive at 3 months age
Background: Neonates with less than 32-34 weeks of gestation are prone to feeding intolerance and Necrotizing Entrocolitis (NEC).Different methods for feeding have been used in the world and several studies have been made to evaluate the outcomes of these methods.Objective: To compare two methods of feeding of very low birth weight (VLBW) premature neonates in two hospitals(both affiliated to Iran,Isfahan University of Medical Sciences)and to evaluate the effects of these methods on feeding tolerance as well as risk of NEC.Methods: This prospective case-control Analytic study was performed on 68 healthy premature neonates in each hospitals(that we said above) in 2003.In method which we used in Beheshti hospital(No.1 method),feeding initiated with 2-3 ml of breast milk every 2 hr and advanced daily 15-25 ml/kg. In method which we used in Alzahra hospital(No.2 method),feeding initiated with 1-2 ml of breast milk every 1 hr. And advanced daily 1 ml to each feeding,until 150 ml/kg/24 hr. We filled a
• We evaluated the nucleated red blood cell (NRBC) counts in all infants with very low birth weight admitted to our neonatal intensive care unit from 1983 to 19
Here, we aimed to evaluate the incidence and mortality of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus (PHH) among very-low-birth-weight (VLBW) infants in Korea and assess the associated factors of PHH. This cohort study used prospectively collected data from the Korean Neonatal Network (KNN). Among 2,386 VLBW infants in the KNN database born between January 2013 and June 2014, 63 infants who died without brain ultrasonography results were excluded. Maternal demographics and neonatal clinical characteristics were assessed. The overall incidence of IVH in all the VLBW infants was 42.2% (987 of 2,323), while those of IVH grade 1, 2, 3, and 4 were 25.1%, 7.0%, 4.8%, and 5.5%, respectively. The incidence and severity of IVH showed a negatively correlating trend with gestational age and birth weight. PHH developed in 0%, 3.5%, 36.1%, and 63.8% of the surviving infants with IVH grades 1, 2, 3, and 4, respectively. Overall, in the VLBW infants, the IVH-associated mortality rate ...
Comment on Increased caesarean section rate over time (1994-2006) is not associated with improved outcomes in very low birth weight infants ...
Sodium and potassium levels were measured weekly in mothers milk and in serum and urine of 41 supplemented and 25 unsupplemented very-low-birth-weight infants whose mean birth weights were 1390g and 1332g, respectively (mean gestational age, 31 weeks). Sodium intake was 5.95mmol/kg/day for the supplemented group and 2.75mmol/kg/day for controls. None of the infants in either group was hyponatremic during the 6-week period of study. Urinary sodium in the supplemented group was 15.7mmol/L as compared with 7.5mmol/L in controls. Human milk sodium was significantly lower than reported elsewhere. Growth in the supplemented group was greater than in the unsupplemented group. Since no episode of hyponatremia occurred, it was concluded that routine sodium supplementation was ...
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Handling of Healthy Very Low birth Weight Infants during Their Initial Hospitalization Effects on Motor Behavior". Prof. Paul J.M. Helders , Wilhelmina Childrens Hospital, Utrecht, The Netherlands, July 1991. Scope of Study. "The study was carried out at the high care unit of the Department of Neonatology of the Wilhelmina Childrens Hospital in premature infants with gestational age at birth of 32 weeks or less and/or a birth weight of less than 1500 grams.. We chose a non-moving position of both hammock and other means of positioning, thus excluding among other vestibular stimulation. Our program aimed to simulate the intra-uterine tactile stimulation by the inner surface of the uterus as it occurs towards the end of gestation..". Summary of Findings and Assumptions. "..For this study a hammock was designed in which the experimental infants, when in the supine position, were nursed for three consecutive weeks. In the lateral position, they were supported by flannelette blankets. Control ...
ළදරු ආසාදන ලෙස සලකණු ලබනුයේ උපතේ සිට පළමු සති 04 ඇතුලත සෑදෙන රෝගාබාධ වේ.[1] මේවා වර්ග තුනකින් සලකා බැලිය හැක. එනම් මව් කුස තුලදී, උපත සිදුවන විට කුහරය තුලදී (perinatal),හො උපතින් පසු.[2] සමහර ආසාදන උපත සිදුවන විට බලාපොරුත්තු විය හැක, නමුත් අනෙක් ආසාදන උපතින් පසු සතියකින් හො මසකින් ඇතිවිය හැක. HIV, hepatitis B, malaria වැනි ආසාදන උපතට පෙර ඇතිවන නමුත් බොහො කලක් යනතෙක් නොපෙනේ. There is a higher risk of infection with preterm or low birth weight neonates. Respiratory tract ...
Premature birth remains a significant health concern and an increasing proportion of very low birth weight infants are surviving. As a consequence, neonatologis...
To the best of our knowledge, this is the first study assessing the glucose regulation in young adults with VLBW in an Asian population. Our study has indicated that 19% of young adults with VLBW already had hyperglycaemia: type 2 diabetes, IGT, IFG and non-diabetes/IGT/IFG with high 1 h plasma glucose level. A report from the Japanese Ministry of Health, Welfare, and Labour in 2007 showed that of 204 general young adults (aged 20-29 years), two individuals (0.98%) had high levels of HbA1c (,6.0%; NGSP equivalent values),18 while 3.6% of young adults with VLBW had the HbA1c values ,6.0% in the present study. In a previous study, Hovi et al9 reported that VLBW infants in young adulthood had higher indexes of glucose intolerance compared with term infants. A recent epidemiological study has also shown that preterm birth is associated with an increased risk of diabetes in young adults.8 On the other hand, a study in the Netherlands showed that preterm birth was not associated with reduced insulin ...
SATURDAY, April 27, 2019 (HealthDay News) -- Another reason breast is best: Breast milk boosts levels of chemicals crucial for brain growth and development in premature babies with a very low birth weight, a new study reveals.. "Our previous research established that vulnerable preterm infants who are fed breast milk early in life have improved brain growth and neurodevelopmental outcomes," said Catherine Limperopoulos, director of MRI research of the developing brain at Childrens National Health System in Washington, D.C.. However, she added, "It was unclear what makes breastfeeding so beneficial for newborns developing brains.". For the new study, her team used "proton magnetic resonance spectroscopy" to solve the mystery. The non-invasive imaging reveals the chemical makeup of specific brain structures, enabling researchers to measure metabolites essential for growth.. With this technology, the researchers examined the brains of very low birth weight babies (under 3.3 pounds). The infants ...
A review of recent prospective evidence. Asthma education teaches strategies to recognize the signs and symptoms of asthma, avoid factors that trigger attacks, and use asthma-controlling drugs correctly. They showed that very low birth weight was associated with signs of impaired glucose regulation in young adult life, suggesting that persons with very low birth weight might be more vulnerable to disorders such as type 2 diabetes and cardiovascular disease in later life. Adherence to medications was not measured by Tegethoff and coworkers. Longer-acting bronchodilators, such as salmeterol and formoterol, are used for long-term control of asthma in combination with an inhaled glucocorticoid eg, Advair and Symbicort , but not for rapid relief of symptoms. The association between low birth weight and an increased risk of metabolic disorders in later life is well documented Meta-analysis finds use of inhaled corticosteroids during pregnancy safe:. Inhaled corticosteroids (ICSs) are medicines used ...
Background: Very low‐birth‐weight (VLBW) infants are at risk for neurodevelopment impairment. This study assessed the effect of early aggressive parenteral nutrition (PN) on long‐term outcome in VLBW infants. Materials and Methods: Directly after birth, VLBW infants (birth weight ,1500 g, n = 142) were randomized to 5 different PN regimes. Controls (n = 46) received glucose and standard‐dose amino acids (AAs; 2.4 g/[kg·d]) from birth onward and pure soybean oil fat emulsion (SOY) on the second day of life. Two intervention groups received glucose, standard‐dose AAs, and lipids from birth onward: SOY (n = 24) or mixed fat emulsion (MIX, n = 25). The 2 other intervention groups received glucose, high‐dose AAs (3.6 g/[kg·d]), and lipids from birth onward: SOY (n = 24) or MIX (n = 23). The primary outcome of this follow‐up study was the composite outcome of "death or major disability" at 2 years corrected age. Secondary outcomes were death, major disabilities, neurodevelopmental ...
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Lactodex starter powder is fortified infant milk formula for new born babies. It is prescribed for pre-term and term infants with low birth weight. Lactodex contains milk solids, sucrose, maltodextrin, minerals, vitamins and antioxidant.. These nutrients are present in optimum levels for healthy growth and normal development of infants. The formula is also used for slightly lactose intolerant babies.. Breast milk is considered as the best food for neonates as it has several nutritional and immunologic advantages. But at the same time human milk is an inadequate source of protein and minerals and calories for premature babies. Very low birth weight babies need higher calories, protein and minerals to achieve adequate catch up growth. Premature infants need fortification of human milk to achieve growth as recommended.. Lactodex is a brand of Raptakos Brett & Co. Ltd. Established in 1930, Raptakos Brett & Co. Ltd. is a global pharmaceutical manufacturing company, renowned internationally for its ...
Very low birth weight (VLBW) preterm infants exposed to gastric acid inhibitors are at a high risk of late-onset sepsis (LOS), reported a recent.... 08 Dec, 2017. ...
Despite advances in neonatal care over the past 2 decades, BPD remains a significant cause of morbidity and mortality in neonates. Recent literature from the National Institute of Child Health reviewing trends in neonatal care and outcomes among extremely low birth weight infants (ELBWs) showed a significant improvement in the survival to discharge of preterm ELBWs, but this was accompanied by an increase in BPD rates [28]. While this increase in BPD rates could be secondary to the improved survival of ELBWs, therapies for BPD have remained elusive and survivors have significantly higher rates of motor, cognitive and behavioral impairment [29].. Interestingly, emerging evidence now suggests that IT administration of MSCs may regenerate the injured preterm lung. Pre-clinical studies, including those performed in our laboratory, demonstrate that IT MSCs improve alveolar and vascular development, reverse PH and improve pulmonary vascular remodeling in experimental models of BPD [8, 9]. In a seminal ...
The adult IQ (intelligence quotient) of babies born very prematurely or with very low birth weight can be predicted when they are just toddlers, say researchers
A roundup of health-related news focusing on pediatrics, featuring a study on cytomegalovirus (CMV) and its long-term effects on very low-birth-weight infants, and a study that links low-income families with a higher consumption of sugary drinks.
A new study reveals that people who were obese when they were diagnosed with diabetes had a lower rate of total and noncardiovascular deaths compared to those who were of normal weight.
Spontaneous closure of the patent ductus arteriosus in very low birth weight infants following discharge from the neonatal unit ...
The Infant Health and Development Program (IHDP) was a multisite, randomized, controlled trial of an educational intervention until three years of age for low birth weight preterm infants born in 1984-1985. There were three components to the intervention: (1) an educational program delivered through home visits (weekly during the first year and every other week during the second and third years of life), (2) a daily center-based program beginning at 12 months corrected for duration of gestation, and (3) parent support groups coinciding with the start of the center-based program. Previously, the subjects were assessed at baseline up to age 3 (Phase I), age 5 (Phase II), and age 8 (Phase III). Phase IV assessed them at age 18. This data collection contains selected variables from all four phases that were used in analyses reported in two articles by the principal investigators and others: McCormick, Marie C., Jeanne Brooks-Gunn, Stephen L. Buka, Julie Goldman, Jennifer Yu, Mikhail Salganik, David ...
CUNHA, Gicelle S.; MEZZACAPPA FILHO, Francisco and RIBEIRO, José D.. Maternal and neonatal factors affecting the incidence of bronchopulmonary dysplasia in very low birth weight newborns. J. Pediatr. (Rio J.) [online]. 2003, vol.79, n.6, pp.550-556. ISSN 0021-7557. http://dx.doi.org/10.1590/S0021-75572003000600015.. OBJECTIVE: To determine the incidence of bronchopulmonary dysplasia, to identify maternal and neonatal factors associated with the disease, and to determine the correlation between bronchopulmonary dysplasia and the progress of newborns. METHODS: Data were prospectively collected on 153 infants born in Campinas (state of São Paulo, Brazil) from September 2000 to April 2002 weighing less than 1,500 g and treated at the University Hospital. The ratio of incidence rates with 95% CI, Breslow-Cox regression, Students t test, linear regression and the Fishers exact test were utilized. RESULTS: Among the 124 babies who survived until 28 days of age, 33 (26.6%) developed bronchopulmonary ...
The landmark study, whose lead author was Sandra Sullivan M.D. with the department of pediatrics at the University of Florida, Gainesville, concludes that for very low-birth-weight preterm infants weighing less than 1250 grams, an exclusively human milk-based diet is associated with significantly lower rates of necrotizing enterocolitis (NEC) and surgical NEC, when compared to a very low-birth-weight preterm infant who received a diet that includes bovine milk-based products. NEC is a severe complication that often affects preterm infants, in which the intestinal tissue disintegrates. It is a serious disease with a mortality rate approaching 25%1. The results of the study are significant because, until recently, the standard of care and the only human milk fortifiers available were bovine-based (cows milk). This posed challenges for the nutritional care of very low-birth-weight preterm infants in the NICU because of the occurrence of intolerance to feedings, possibly as a result of exposure to ...
We sought to determine whether there are sex-based differences in the requirements for calories or protein for optimal growth during the transition phase (TP) when an extremely low birth weight (ELBW) infant, defined as a preterm infant with a birth weight of | 1000 g, is progressing from parenteral to enteral feeds. A retrospective review of ELBW infants born from 2014 to 2016 was performed at a tertiary NICU. Infants with necrotizing enterocolitis, short bowel syndrome, or chromosomal anomalies were excluded. TP was defined as the period when the infants enteral feeds were increased from 30 up to 120 ml/kg/day while weaning parenteral nutrition (PN). Effects of sex and protein-calorie intake on the change in growth parameters from the beginning to the end of TP were analyzed. Pre-TP growth percentiles and calorie and protein intake were similar in both sexes. There was a significant (r = 0.22, p = 0.026) correlation of total calorie intake with a change in weight percentiles (wt.pc) for the whole
Objective: This study evaluated the cost-effectiveness of a 100% human milk-based diet composed of mothers milk fortified with a donor human milk-based human milk fortifier (HMF) versus mothers milk fortified with bovine milk-based HMF to initiate enteral nutrition among extremely premature infants in the neonatal intensive care unit (NICU).. Methods: A net expected costs calculator was developed to compare the total NICU costs among extremely premature infants who were fed either a bovine milk-based HMF-fortified diet or a 100% human milk-based diet, based on the previously observed risks of overall necrotizing enterocolitis (NEC) and surgical NEC in a randomized controlled study that compared outcomes of these two feeding strategies among 207 very low birth weight infants. The average NICU costs for an extremely premature infant without NEC and the incremental costs due to medical and surgical NEC were derived from a separate analysis of hospital discharges in the state of California in ...