Background:The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-beta, we hypothesized that infants with NEC also have low blood TGF-beta levels. We further hypothesized that because fetal inflammation increases the risk of NEC, infants who develop NEC
Objective: The purpose of this study was to evaluate neurodevelopmental outcome in extremely-low-birth-weight (ELBW) infants, all of whom had 3 characteristics: gestational age (GA) less than or equal to24 weeks, birth weight less than or equal to750 g, and 1-minute Apgar score less than or equal to3. Study design: Surviving infants were evaluated at 18 to 22 months corrected age with a neurologic examination and the Bayley II Mental and Psychomotor Developmental Index (MDI and PDI).
Preterm infants are at risk of exhausting their body iron stores much earlier than healthy term newborns. It is widespread practice to give enteral iron supplementation to preterm and low birth weight infants to prevent iron deficiency anaemia. Howev
We sought to determine whether there are sex-based differences in the requirements for calories or protein for optimal growth during the transition phase (TP) when an extremely low birth weight (ELBW) infant, defined as a preterm infant with a birth weight of | 1000 g, is progressing from parenteral to enteral feeds. A retrospective review of ELBW infants born from 2014 to 2016 was performed at a tertiary NICU. Infants with necrotizing enterocolitis, short bowel syndrome, or chromosomal anomalies were excluded. TP was defined as the period when the infants enteral feeds were increased from 30 up to 120 ml/kg/day while weaning parenteral nutrition (PN). Effects of sex and protein-calorie intake on the change in growth parameters from the beginning to the end of TP were analyzed. Pre-TP growth percentiles and calorie and protein intake were similar in both sexes. There was a significant (r = 0.22, p = 0.026) correlation of total calorie intake with a change in weight percentiles (wt.pc) for the whole
THURSDAY, Oct. 5, 2017 (HealthDay News) -- Delivery characteristics of extremely preterm infants can be used to identify those with significantly lower incidence of early-onset sepsis (EOS), according to a study published online Oct. 5 in Pediatrics.. Karen M. Puopolo, M.D., Ph.D., from Childrens Hospital of Philadelphia , and colleagues analyzed data from infants born at 22 to 28 weeks gestation in Neonatal Research Network centers from 2006 to 2014 to determine whether factors evident at birth could be used to identify premature infants at lower risk of EOS (≤72 hours age).. The researchers found that of 15,433 infants, 37 percent met low-risk criteria (delivered via cesarean delivery, with membrane rupture at delivery, and absence of clinical chorioamnionitis). Among infants surviving ,12 hours, EOS incidence was 29 out of 5,640 (0.5 percent) in the low-risk group versus 209 out of 8,422 (2.5 percent) in the comparison group (adjusted relative risk, 0.24). Prolonged antibiotics (five or ...
Population-based surveys are needed to reliably follow the overall outcome of the extremely premature infants. In our study, we followed 2 population-based ELBW infant cohorts with all births included and, therefore, we consider our results to provide a real situation of the care and outcome of ELBW infants in our country. Because practically all infants born before the 27th GW were included in both cohorts, comparisons between the gestational-age groups in infants born at 22 to 26 GWs were possible. The birth weight-based inclusion criterion can be criticized because it will result in an increasing proportion of SGA infants with increasing gestational age, as was the case. We considered it, however, a relevant criterion because it was the criterion of the previous cohort, and also the criterion for the Finnish national ELBW infant register.. The stillborn rates were relatively high in both cohorts compared with reported rates elsewhere.1,23,24 In Finland, all infants without any signs of life ...
This application proposes to continue the participation of investigators at UCSF in an interactive network of six centers, the Asthma Clinical Research Network (ACRN) in conducting studies of novel therapies for asthma and in disseminating findings to the practicing community. The need for such a network was suggested by increases in the mortality, morbidity, prevalence, and costs of asthma, by research studies showing that asthma is linked to airway inflammation, and by the accelerating rate of development of potentially effective, but also potentially costly treatments. Defining the place of these new therapies was seen as requiring collaborative, multi-center studies examining subjects reflecting the diversity of the U.S. population. In its first 5 years, the ACRN established an interactive infrastructure and added a research site at Harlem Hospital, New York, which serves a predominantly minority population. The ACRN completed and published trials of the effects of regular use of a ...
Objective : In this study, we aimed to produce basic data on the prenatal environmental risk factors of low birth weight infants at a community level. Methods : In 2000, we conducted the direct interview using questionnaire about prenatal environmental risk factors with low birth weight infant-delivered mothers and normal weight infant-delivered mothers in Asan-city, Chungcheongnamdo Province, Korea. The questionsgiven to the mothers included past pregnancy history, menstrual status, disease history before and during the pregnancy, family history, environmental risk factors and exposure history. The responses of the twogroups were compared to calculate the prenatal environmental risk factors of each group. Results : Mothers smoking was significantly associated with low birth weight infants (adjusted odds ratio(AOR) 3.27; 95% confidence interval (CI) 1.25-8.56) and preterm baby (AOR 4.20; 95% CI, 1.21-14.61). Other environmental risk factors were not significantly different between the two ...
Results Seventeen ELBW infants had PTU in labour delivery room (n=17) yielding 34 recordings. For 5 out of 17 (29.4%) infants significant improvement of ETT position could be offered by the use of PTU which otherwise was not detected. It is feasible to measure and record diaphragmatic excursion bilaterally during the labour ward resuscitation environment. The diagnostic accuracy of PTU for correct ETT was greater than that by traditional clinical methods and colorimetric CO2 detection. Inter-operator consistency and value of hand-held device (VScan®) is being evaluated.. ...
A set of maternal and neonatal risk factors appear to be useful in predicting which extremely-low-birth-weight infants will die after leaving the neonatal intensive care unit, researchers found.
Read the article here Women who have large birth weight infants (9 pounds or more) most likely had gestational diabetes, or glucose intolerance at the least. These women had the genetic predisposition to insulin imbalance BEFORE pregnancy…they just didnt know it. Most found out they had insulin imbalance and blood sugar issues at the 24th-28th…
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Archives of Disease in Childhood - Fetal and Neonatal Edition Jan 2018, 103 (1) F79-F81; DOI: 10.1136/archdischild-2017-312917 ...
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TY - JOUR. T1 - Predicting mortality risk for infants weighing 501 to 1500 grams at birth. T2 - A National Institutes of Health Neonatal Research Network report. AU - Horbar, J. D.. AU - Onstad, L.. AU - Wright, E.. AU - Yaffe, S. J.. AU - Catz, C.. AU - Wright, L. L.. AU - Malloy, M. H.. AU - Rhoades, G. G.. AU - Gordon, T.. AU - Phillips, E.. AU - Oh, W.. AU - Cassady, G.. AU - Philips, J.. AU - Lucey, J. F.. AU - Fanaroff, A. A.. AU - Hack, M.. AU - Tyson, J. E.. AU - Uauy, R.. AU - Poland, R.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Objectives: To develop and evaluate a model that predicts mortality risk based on admission data for infants weighing 501 to 1500 grams at birth, and to use the model to identify neonatal ICUs where the observed mortality rate differs significantly from the predicted rate. Design: Validation cohort study. Setting: University-based, tertiary care neonatal ICUs. Patients: Sample of 3,603 infants with birth weights of 501 to 1500 grams who were born at seven National ...
Why is it illusion to expect any benefit from generalization, unselected treatment strategy using the currently available targeted drugs? What are the genetic variation-based convincing data that accumulating proves now the need for a revolution in discovery drugs research arena and randomized trials design? Why and how quantitative genetics, personal genomics and systems biology [3- 6] represent the most rational scientific approaches to achieve the major goal of a patient-tailored management of solid cancers ...
With standardization of D2 surgery and systemic treatment with chemotherapy and targeted therapy with trastuzumab for HER2 (Human Epidermal Growth Factor Receptor 2)-positive gastric cancer, there is an end of this conventional medicine era. Now, two new scientific directions are being shaped: laparoscopic surgery for improving quality-of-life and systems pharmacology based on genome integrative analysis. Challenges and potential of this genomic medicine are discussed. (Citation: Gastric & Breast Cancer 2012; 11(3): 146-148). ...
Modeling the Population Health Dynamics of Diabetes & Obesity Syndemics Bobby Milstein Syndemics Prevention Network Centers for Disease Control and Prevention - PowerPoint PPT presentation NOTE: The person who provided this presentation may remove the download file from their website at any time ...
Bagi Pengarah Pemasaran ZM Network Centre, Hafizah Abdul Latiff, idea menghasilkan produk berasaskan pemakanan Nabi Muhammad SAW, SihatSunnah tercetus selepas m
For more than 50 years, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported and conducted research on the processes of human development and how they affect health, from preconception through adulthood. The history of the NICHD is not a series of solitary endeavors; instead, the NICHD is, and has always been, a family-a whole that is truly the sum of its unique and extraordinary parts.
Fibroid tumors-the sometimes painful uterine growths affecting many American women-lack a key protein that plays a role in holding tissues together, according to a study by researchers from the Uniformed Services University of the Health Sciences (USUHS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.
Copyright © 2014 by the American Academy of Pediatrics. OBJECTIVE: Prophylactic indomethacin reduces severe intraventricular hemorrhage but may increase spontaneous intestinal perforation (SIP) in extremely low birth weight (ELBW) infants. Early feedings improve nutritional outcomes but may increase the risk of SIP. Despite their benefits, use of these therapies varies largely by physician preferences in part because of the concern for SIP. METHODS: This was a cohort study of 15 751 ELBW infants in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network from 1999 to 2010 who survived beyond 12 hours after birth. The risk of SIP was compared between groups of infants with and without exposure to prophylactic indomethacin and early feeding in unadjusted analyses and in analyses adjusted for center and for risks of SIP. RESULTS: Among infants exposed to prophylactic indomethacin, the risk of SIP did not differ between the ...
Yesterday, House Democratic Whip Steny Hoyer (D-MD) and Rep. Peter King (R-NY) introduced H.R. 2152, the Eunice Kennedy Shriver Act, with 30 original cosponsors. It passed the House last year with broad bipartisan support. This legislation honors the legacy of Eunice Kennedy Shriver and supports people with intellectual disabilities and their families. The Eunice Kennedy Shriver Act would reauthorize the Special Olympics Sport and Empowerment Act, authorize the Department of Education to make grants to the Best Buddies organization to support the expansion and development of mentoring programs for people with intellectual disabilities, and support the establishment of Eunice Kennedy Shriver Institutes for Sport and Social Impact. All of these programs improve and advance opportunities for people with intellectual disabilities to fully participate and engage in sports and recreation, social activities, and other community opportunities.
Improved survival rates and earlier discharge of preterm (,37 weeks gestation at birth) and low birth weight (,2500 g at birth) infants have increased the number of small infants who are being transported in private vehicles. Car safety seats that are used correctly are 71% effective in preventing fatalities attributable to passenger car crashes in infants.1 To ensure that preterm and low birth weight infants are transported safely, the proper selection and use of car safety seats or car beds are necessary.. Federal Motor Vehicle Safety Standard (FMVSS) 213, which establishes design and dynamic performance requirements for child-restraint systems, applies to children weighing up to 65 lb. However, the standard has no minimum weight limit and does not address the relative hypotonia and risk of airway obstruction in preterm or low birth weight infants. Most rear-facing car safety seats are designated by the manufacturer for use by infants weighing more than 4 or 5 lb, with some designated for use ...
TY - JOUR. T1 - Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation. AU - Wyckoff, Myra H.. AU - Salhab, Walid A.. AU - Heyne, Roy J.. AU - Kendrick, Douglas E.. AU - Stoll, Barbara J.. AU - Laptook, Abbot R.. PY - 2012/2. Y1 - 2012/2. N2 - Objective: To determine whether delivery room cardiopulmonary resuscitation (DR-CPR) independently predicts morbidities and neurodevelopmental impairment (NDI) in extremely low birth weight infants. Study design: We conducted a cohort study of infants born with birth weight of 401 to 1000 g and gestational age of 23 to 30 weeks. DR-CPR was defined as chest compressions, medications, or both. Logistic regression was used to determine associations among DR-CPR and morbidities, mortality, and NDI at 18 to 24 months of age (Bayley II mental or psychomotor index ,70, cerebral palsy, blindness, or deafness). Data are adjusted ORs with 95% CIs. Results: Of 8685 infants, 1333 (15%) received DR-CPR. Infants who ...
Dietary protein is needed for normal growth and development. The protein intake required for growth of the low birth weight infant has been estimated by the growth rate of the fetus to be 3.5 to 4.0 g/kg/d. Controlling the amount of protein given to low birth weight babies (less than 2.5 kg) fed with formula is important. Too much protein can raise blood urea and amino acid (phenylalanine) levels, and this may harm neurodevelopment. Too low protein intake may limit the growth of these infants. The review authors searched the medical literature to identify studies that compared protein intake as follows: between 3 and 4 g of protein per kg of infant body weight each day versus less than 3.0 g/kg/d or greater than 4.0 g/kg/d by low birth weight infants fed formula during their initial hospital stay. Increased protein intake resulted in greater weight gain of around 2.0 g/kg/d. Based on increased body incorporation of nitrogen, this was associated with increased lean body mass. The present ...
Gantz MG, Carlo WA, Finer NN on behalf of the SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, et al ...
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The purpose is to collect baseline and outcome data in a uniform manner on a large cohort of VLBW and other sick infants admitted to neonatal intensive care units.. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is generic). Baseline data is collected soon after admission to the NICU; outcome data is collected at the time of death or discharge from the hospital. The data collected includes information on:. ...
The Generic Database (GDB) is a registry of very low birth weight infants born alive in NICHD Neonatal Research Network (NRN) centers. The purpose is to collect baseline and outcome data in a uniform manner on a large cohort of VLBW and other sick infants admitted to neonatal intensive care units.. The GDB collects observational baseline data on both mothers and infants, and the therapies used and outcomes of the infants. The information collected is not specific to a disease or treatment (i.e., it is generic). Baseline data is collected soon after admission to the NICU; outcome data is collected at the time of death or discharge from the hospital. The data collected includes information on:. ...
A new method for direct measurement of airway pressure using a fiber optic pressure sensor (FOPS) has been tested in very low birth weight infants during mechanical ventilation. Airway pressure and ventilatory flow was recorded in an initial investig
Programs Calendar with Balancing the Nutritional Needs of Very Low Birth Weight Infants with the Protective Properties of Human Milk - June ...
Interventions for treatment of neonatal hyperglycemia in very low birth weight infants: Cochrane systematic review answers are found in the Cochrane Abstracts powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
BACKGROUND: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available ESAs. OBJECTIVES: To assess the effectiveness and safety of ESAs (erythropoietin (EPO) and/or Darbe) initiated early (before eight days after birth) compared with placebo or no intervention in reducing red blood cell (RBC) transfusions, adverse neurological outcomes, and feeding intolerance including necrotising enterocolitis (NEC) in preterm and/or low birth weight infants ...
Background: One of the most common methods of identifying mortality risk is the Clinical Risk Index for Babies scoring system (CRIB- II). The aim of this study was assessing the value of CRIB- II in predicting mortality risk in preterm and low birth weight infants in East Azerbaijan- Iran. Materials and Methods: This prospective cohort study was carried out in 2013-2014 during 6 months in NICUs of Alzahra, Taleqani and Children hospitals of Tabriz-Iran. All infants ≤ 32 weeks gestational age or ≤ 1500gr birth weight were included in the study using consecutive method. After calculating CRIB- II score, the infants were followed up at 3 months of age and their outcome was determined. The data was analyzed using SPSS-13, t- test, receiver operating characteristics (ROC) and area under curve (AUC) and relative risk (RR). Results: Of total 215 infants, 64 infants (29.7%) died in the hospital and one infant (0.4%) died after discharging from the hospital. 150 (68.8%) infants, were alive at 3 months age
University of Iowa researchers Matthew Rysavy, a senior medical student, and Edward Bell, MD, professor of pediatrics in the Stead Family Department of Pediatrics, studied the cases of nearly 5,000 infants born before 27 weeks gestation at 24 academic hospitals participating in the Neonatal Research Network between 2006 and 2011. The Network is part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Their results will be published in the New England Journal of Medicine on May 7. Rysavy, Bell, and their collaborators studied the births to determine which extremely preterm infants received active care - efforts to save the life of the infant - and which received only comfort care - keeping the infant comfortable until he or she passed away. "We were interested in the differences in outcomes that exist for the earliest preterm infants among U.S. academic medical centers," Rysavy says. "There are large differences in outcomes like mortality and childhood delays ...
There is now quite a lot of evidence that premature or low birth weight children have a greater risk of learning and physical disabilities and this is further supported by a new Finish study. Looking at children born between 1996 and 1997 with Extremely Low Birth Weight (ELBA), e.g. birth weight below 1000g or 2.2lbs, the study assessed the children at the age of five. ...
The Eunice Kennedy Shriver National Institute of ChildHealth and Human Development (NICHD) was established by President John F. Kennedy n 1962 to better understand processes of human development and how they affect health from preconception through adulthood. Over the course of its 50 year history, the NICHD has continued to advance scientific knowledge to further its mission to help children have the chance to achieve their full potential for healthy and productive lives, free from injury, disease or disability. ...
Welcome to the Pfeifer Lab We are part of the Genetics and Epigenetics of Development Affinity Group https://www.nichd.nih.gov/about/org/dir/affinity/GED/Pages/default.aspx at the Eunice Kennedy Shriver National Institute of Child Health and Human Develop
12 Jan 2018. The first three-dimensional structure of DHHC proteins--enzymes involved in many cellular processes, including cancer--explains how they function and may offer a blueprint for designing therapeutic drugs.. Researchers have proposed blocking DHHC activity to boost the effectiveness of first-line treatments against common forms of lung and breast cancer.. However, there are currently no licensed drugs that target specific DHHC enzymes.. The study, led by researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), appears in the latest issue of Science. NICHD is part of the National Institutes of Health.. DHHC enzymes, also called palmitoyltransferases, modify other proteins by attaching to them a chain of lipids, or fatty acids, of varying lengths.. This modification, called palmitoylation, can change many properties of a target protein, such as its structure, function and location within a cell.. Researchers estimate that nearly 1,000 ...
Welcome to the laboratory of Richard J. Maraia, M.D. Section on Molecular and Cell Biology, Intramural Research Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of
A Grant from Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), RC4HD066915 supported website development. Contents are solely the responsibility of the authors and do not represent the official views of NICHD ...
A Grant from Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), RC4HD066915 supported website development. Contents are solely the responsibility of the authors and do not represent the official views of NICHD ...
Dec 20, 2013 "It is heartbreaking to know that there are low-cost interventions to manage preterm birth and care for preterm infants, but without enough frontline health workers and without implementation of known interventions, more than a million preterm babies die every year," Sarah Alexander, the director of external relations at the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), an initiative of Seattle Childrens, writes in the Bill & Melinda Gates Foundations "Impatient Optimists" blog. "In a global call to action, scientific experts from the Bill & Melinda Gates Foundation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, GAPPS, and the March of Dimes Foundation published in Lancet Global Health A solution pathway for preterm birth: accelerating a priority research agenda," she notes, adding, "The solution pathway includes critical steps in development and delivery science that can help scale up interventions to improve the survival ...
The UC Davis MIND Institute has been named an Intellectual and Developmental Disabilities Research Center (IDDRC), through a prestigious grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health — a distinction held by only a handful of neurodevelopmental centers nationwide committed to the diagnosis, prevention, treatment and amelioration of developmental disorders such as autism, fragile X syndrome and Down syndrome.
ABSTRACTIn April 2008, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the American College of Obstetricians and Gynecologists, and the Society for Maternal-Fetal Medicine partnered to sponsor a 2-day workshop to revisit nomenclature, interpretation, and research
APTAs Section on Research hosted a fly-in March 19-20 in Washington, DC, to advocate on behalf of rehabilitation research and for increased funding for programs within the National Institutes of Health (NIH). Eleven researchers from 9 states met with staff of the Senate and House appropriations committees and their individual members of Congress. The researchers asked for funding increases for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which is the housing institute for the National Center for Medical Rehabilitation Research; the National Institute of Neurological Disorders and Stroke (NINDS); and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). In addition, they requested report language on the benefits of prioritizing rehabilitation research in the translational science research agenda. The researchers received positive feedback from committee members and individual members of Congress on the benefits of ...
APTAs Section on Research hosted a fly-in March 19-20 in Washington, DC, to advocate on behalf of rehabilitation research and for increased funding for programs within the National Institutes of Health (NIH). Eleven researchers from 9 states met with staff of the Senate and House appropriations committees and their individual members of Congress. The researchers asked for funding increases for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which is the housing institute for the National Center for Medical Rehabilitation Research; the National Institute of Neurological Disorders and Stroke (NINDS); and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). In addition, they requested report language on the benefits of prioritizing rehabilitation research in the translational science research agenda. The researchers received positive feedback from committee members and individual members of Congress on the benefits of ...
Inductions have been rising, said Dr. Caroline Signore, an obstetrician-gynecologist at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the US National Institutes of Health (NIH), who wrote an accompanying commentary in the journal.. In 1990, just 9.5 percent of US women had labor-induced deliveries, she writes, but the rate was 22.5 percent by 2006.. The new study, she says, puts a number on what experts suspected - that the rise in induced labors is driving the rise in C-sections - now at an all-time high of 32 percent of deliveries in the United States.. Elective inductions should not be done before 39 weeks gestation, according to recommendations by the American College of Obstetricians and Gynecologists (ACOG), but that guideline is not rigorously followed, Dr. Signore notes. In the study, some of the women were induced as early as 37 weeks.. In 37 percent of the women induced, the cervix was not sufficiently ready for delivery, Dr. Ehrenthal ...
Summary: This FOA issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the National Heart, Lung and Blood Institute (NHLBI); the National Cancer Institute (NCI); the National Center for Complementary and Alternative Medicine (NCCAM), Office of Dietary Supplements (ODS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD of the National Institutes of Health (NIH), encourages research grant applications from institutions/organizations that propose to conduct exploratory/developmental clinical studies that will accelerate the development of effective interventions for prevention or treatment of overweight or obesity in adults and/or children. Exploratory epidemiological research with a goal of informing translational/clinical research will also be supported within this program. Link: http://grants.nih.gov/grants/guide/pa-files/PAR-12-257.html Exploratory/Developmental Clinical Research Grants in Obesity (R21). Award ...